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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZCCHC7-UBE2R2 (FusionGDB2 ID:100032)

Fusion Gene Summary for ZCCHC7-UBE2R2

Fusion gene summary

Fusion gene information	Fusion gene name: ZCCHC7-UBE2R2
	Fusion gene ID: 100032
		Hgene	Tgene
	Gene symbol	ZCCHC7	UBE2R2
	Gene ID	84186	54926
	Gene name	zinc finger CCHC-type containing 7	ubiquitin conjugating enzyme E2 R2
	Synonyms	AIR1\|HSPC086	CDC34B\|E2-CDC34B\|UBC3B
	Cytomap	9p13.2	9p13.3
	Type of gene	protein-coding	protein-coding
	Description	zinc finger CCHC domain-containing protein 7TRAMP-like complex RNA-binding factor ZCCHC7zinc finger, CCHC domain containing 7	ubiquitin-conjugating enzyme E2 R2E2 ubiquitin-conjugating enzyme R2ubiquitin carrier protein R2ubiquitin conjugating enzyme E2R 2ubiquitin-conjugating enzyme E2-CDC34Bubiquitin-conjugating enzyme UBC3Bubiquitin-protein ligase R2
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000336755, ENST00000534928, ENST00000461038, ENST00000322831,	ENST00000263228,
Fusion gene scores	* DoF score	29 X 11 X 11=3509	21 X 13 X 10=2730
	# samples	29	26
	** MAII score	log2(29/3509*10)=-3.59693514238723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/2730*10)=-3.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZCCHC7 [Title/Abstract] AND UBE2R2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZCCHC7(37126939)-UBE2R2(33917015), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	UBE2R2	GO:0006513	protein monoubiquitination	20061386
Tgene	UBE2R2	GO:0070936	protein K48-linked ubiquitination	20061386

Fusion gene breakpoints across ZCCHC7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across UBE2R2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-77-7338-11A	ZCCHC7	chr9	37126939	+	UBE2R2	chr9	33917015	+

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Fusion Gene ORF analysis for ZCCHC7-UBE2R2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000336755	ENST00000263228	ZCCHC7	chr9	37126939	+	UBE2R2	chr9	33917015	+
intron-3CDS	ENST00000534928	ENST00000263228	ZCCHC7	chr9	37126939	+	UBE2R2	chr9	33917015	+
3UTR-3CDS	ENST00000461038	ENST00000263228	ZCCHC7	chr9	37126939	+	UBE2R2	chr9	33917015	+
In-frame	ENST00000322831	ENST00000263228	ZCCHC7	chr9	37126939	+	UBE2R2	chr9	33917015	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000336755

ZCCHC7

chr9

37126939

ENST00000263228

UBE2R2

chr9

33917015

4103

716

106

762

218

ENST00000322831

ZCCHC7

chr9

37126939

ENST00000263228

UBE2R2

chr9

33917015

4263

876

266

922

218

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000336755	ENST00000263228	ZCCHC7	chr9	37126939	+	UBE2R2	chr9	33917015	+	0.000462131	0.99953794
ENST00000322831	ENST00000263228	ZCCHC7	chr9	37126939	+	UBE2R2	chr9	33917015	+	0.000512281	0.99948764

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Fusion Genomic Features for ZCCHC7-UBE2R2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ZCCHC7	chr9	37126939	+	UBE2R2	chr9	33917015	+	1.02E-10	1
ZCCHC7	chr9	37126939	+	UBE2R2	chr9	33917015	+	1.02E-10	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZCCHC7-UBE2R2

Go to
FGviewer for the breakpoints of chr9:37126939-chr9:33917015
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

UBE2R2

chr9:37126939

chr9:33917015

ENST00000263228

200_238

165.66666666666666

239.0

Compositional bias

Note=Asp/Glu-rich (acidic)

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZCCHC7

chr9:37126939

chr9:33917015

ENST00000336755

241_258

203.33333333333334

544.0

Zinc finger

CCHC-type 1

Hgene

ZCCHC7

chr9:37126939

chr9:33917015

ENST00000336755

263_280

203.33333333333334

544.0

Zinc finger

CCHC-type 2

Hgene

ZCCHC7

chr9:37126939

chr9:33917015

ENST00000336755

304_321

203.33333333333334

544.0

Zinc finger

CCHC-type 3

Hgene

ZCCHC7

chr9:37126939

chr9:33917015

ENST00000336755

348_365

203.33333333333334

544.0

Zinc finger

CCHC-type 4

Tgene

UBE2R2

chr9:37126939

chr9:33917015

ENST00000263228

8_174

165.66666666666666

239.0

Domain

UBC core

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Fusion Gene Sequence for ZCCHC7-UBE2R2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000336755_ENST00000263228_TCGA-77-7338-11A_ZCCHC7_chr9_37126939_+_UBE2R2_chr9_33917015_length(transcript)=4103nt_BP=716nt
CTCCTTACCTCATTTGTCCTCGCCCCTCCCCGTCCCTCTACGCGTTTTGGTTCCCGGTTGGTGCTTCCTGTTCGCAGCTGCGGCACTTCA
AGGTTACTGACTTTTTATGATGTTTGGTGGCTATGAGACTATAGAAGCATACGAAGATGATCTTTATCGAGATGAGTCATCTAGTGAACT
GAGTGTTGATAGTGAGGTGGAATTTCAACTCTATAGCCAAATTCATTATGCCCAAGATCTTGATGATGTCATCAGGGAGGAAGAGCATGA
AGAAAAGAACTCTGGGAATTCGGAATCTTCGAGTAGTAAACCAAATCAGAAGAAGCTAATCGTCCTTTCAGATAGTGAGGTCATCCAGCT
GTCAGATGGGTCAGAGGTCATCACTTTGTCTGATGAAGACAGTATTTATAGATGTAAAGGAAAGAATGTTAGAGTTCAAGCACAAGAAAA
TGCCCATGGTCTTTCTTCTTCTCTTCAATCTAATGAGCTGGTTGATAAGAAATGCAAGAGTGATATTGAGAAGCCTAAATCTGAAGAGAG
ATCAGGTGTAATCCGAGAGGTCATGATTATAGAGGTCAGTTCAAGTGAAGAGGAAGAGAGCACCATTTCAGAAGGTGATAATGTGGAAAG
CTGGATGCTACTGGGATGTGAAGTAGATGATAAAGATGATGATATCCTTCTCAACCTTGTGGGATGTGAAAACTCTGTTACTGAAGGAAA
CAAGTTTCAGCCACTAAGGCCGAAGCAGAAAAGGATGGAGTGAAGGTCCCCACAACCCTGGCGGAATACTGCATCAAAACTAAAGTGCCT
TCCAATGACAACAGCTCAGATTTGCTTTACGACGACTTGTATGATGACGACATTGATGATGAAGATGAGGAGGAGGAAGATGCCGACTGT
TATGATGATGATGATTCTGGGAATGAGGAGTCGTGACGTGCTCCTTCAGTGCCCCTGTACTGCCCTGCCATCTCAGGCCAAAGGGAGGGG
AGCAAGTGGGGACCTGGCCATGGCCCCTCAGCAAAAACCTATTCACAGCGGGTGGGGAAACACACACAGCTCCTGCTGACTCCCCTTATG
GATCTCAGTTTGCTCCTTTTTATGGACCTTTAATGGAGAGAGAGTAACCCTCCACAGAATGTCTGAATTCTTGCATTCTTTACCCTTCCA
TCACTATATTGATTCTTTTTTTAAAAAATATGAACCCAAACTCCCGCCTCACTTCGTCTCTACAGAATGTTCACAGCAAAACACGTTTGG
TCTGTTTTTAGATTCTTGAAGAATTCAATAGTCTTTCAAGATGTTTAATGTGTTTAAAGCTGGGAACCTGTTGGGAGTTCACAAGTGCTG
CATATACTGGGTAGCAAAAGAAAATGGAAAAAAACCCACAAAACAAACTTTAAAAAAAAAAAAAAACAAATTTGCCAAGGTTTAGCTGCT
CATTTACATTAGTGTGTGTGCATTCGTTCAGCCCCATGGTGGTGAATTCTGTTTCTTTCCTTTCCTAAGGCTGGGACATGGTGGGCATCA
GGGACTTTGTGCTAAGCCTGATGAAATGTGCTCCTTCAATCTCCATGAAACCATCGTAACATGGAGGCCTCAGCTGCTCTGAGGAGAGAA
ATCAGACTTTGTTTTTTGAAATCGATTGGGATCGAAAGCCTGAAATAAATATTCATACTTTCCATAGAACTGAGCACTTGGTTGCTATTT
ATTTTAAAGGCAGGGTTATTTCCCCCCAGGGAGTGGGGCAAGCGGGGAAGTTGGGATGAGTGCGTGTGGGAGCAAAGAGTTAAAAATCAC
TATGCTAAGTTTGGTTGATGCTACTGGGGGGAAAAAGTTGAAACTACTGGTGACCACTGTTGGGAGAGGAAACATCTGTTTTATAGATTT
AGCATGGCCTTCCCATCAAAAATACACTCGTACCATGACGTTTTGTTTTTGTTTTTTAAGTAGCCACTTTTAATTACTCAGTATTAATCC
TAGGTGCATGTGTTAAGATTTCGGTTTTCATCGAGCTGCTTATACTGATAGTGAAAAACTTGGATGTGTGTGAGACGAGTTACCGCCTTC
TTCATTGGATGTGATCTGAACTTTTTTTCTCCTTTCAACATACTTAGGCTGTGGAGTGCAAGCAGAATTATGCATAGAAATTGTGGCAGG
GCTGAGGGAGTTGACTGCAGGCAGTTTTTAGGCCAGATAAGGCTAGATCTTCCTGCAATGCACTTGCTGCAGCTTTGATTTTCCAGATCT
CAATCGTGTTGCTTCAATCAATATTGAGATCCAGCAGCCTTCACCATCCAGGAGACTTCAGAACTTGAAGGTAATTTTTGGTTGTTATGG
GGGTGCACCAGATCATAGGAGGGCATTATTTGGAGGAAACCGCTATAATGTAAAATCAGATTTCAGAAGGAAAATGCAGCAAGGACTGAC
TGTAGTCCTATTTCAGACCCCTGGGCACTAGTGTCAACTCCTCCTTTGGCTCGTAACTCAGAAAGAACCAAAGGGCAGATTAGGGACGGG
GCAGGAGGGATCCTAGGATGGCCAGAGTAGGTGACGCTTACTTCCTTAGCTCCTCCTTCCATTCTGATCTCAGGGTTTTCACTCTTCAAA
CTCCCAAACACATGACTTCTTCCCAGCAGCCCTTCCCGGCCTCTAAAGTTTGGTCCCAGCAGCCCTTCCCAGCCTCTAAAGTTTGGTCTG
GTATGAAATGGGACTGTTTAACAAGCAAGGCTCTTAGGGGACACTGTTGAGCCTGGTCCCAGAATCTGTGATCTCCACAGGGCCAGGGTT
GCTACTTGCACCCAGAATCTAGTGATTTTAGTCAGATCCATGGAACAGAGCAGCTTCGTAATACATTGTCAAGTTACCTGATTACAAACT
CTCATAGATGTTGGAACTACCTTTTTACTCCCCATACTTTGTAAGTAATGCTTCCAGATTAACCTGCAAATCTTGTGGAGCCAAAGCCTC
TCACAGTGCTGATTTACCTCCCCCAAAATGCCCCCAAACCCCCATGCAAGTTTACAGCCAGTAGCTTGGTCTTATTCTCTTGGAGCCCTA
AAATTAAGCCTTTCATTCCCCTTTGCTAAAGCATCTCACTCCCAGGGCAGCCCCAGCACCCTGGCATTGCGGGAGGTGCTCTGCTGCACA
GCTGTTCCATCAGGCCCTATTGGCCTCTGTTAGACATTGACTCAGGGAGCCGGAGCGCCAAGTGGAGGTTGTACCTTTCAGCCCTTTGGG
GTGTTAAAAGTGTCAAGGGCTGGGTTTGCCTCTGATGAGTACAATCAGTTCCAGAAGACTGGGTAAGTCTCTTGCTAGCAGGTGGACATT
CTGGTATTTTAGACTGACTGAACGAAACCCAGAGGCTGGTTCCAGAGCTCTGTCCCTGAGAACACATCCCTGTGGAAAATACTTGAGTTT
GTAATTTTTTTTCCCCCTTCTGGGAGTGGAGGTCTCAGGCTCAATCCGGAACCATGTACGTACAGTTTTGCTTATTATTTGATGTGACAT
GAACTCAAAATCCTGCATTTTTAGATTCCTTTTAGTTCTAATTGAGGCCTCACTAGATGCTCTTCAGTTCTGTGTATTTTGAGGCTGGGT
GGAGAAGTATATGATTCTGCTGTTGATTCTTTCAGTCTTCCCCCCTTCTCCTTTTATCAATCATTCCAGAGTTATTTTCTATTAGTCAAA
CTTTTTTGTAGAACCTTCTTTCCCTTACCCTGGCAAATTGCTTCTTTACTTGCTGGTTTCCTTACGTTTGGGGCACATGTTGTAAGAAAC
TGATTGGAAGGGGAAATGTGCAGCTCTCCACTGGAAAGGAACTCTCCACCCCTCCCATCCTGATAAAACAAACAAGGTTTACATTTACAA
CTAAAAGGATTCAGATGCAATTTTCAACTATTCTGAAACCAGCAGGACACACCTGACTTTAATAGTTTTAGCTGAAATTGTAGATGTTTT
GCTTCAGTTTAACTTATGAGAAAAGATTATCTGACGGATTTTGTGTTGACTTCCCCTTTAGTGGTTTATTTTGTCTTTTTCTGCCCATCT

>In-frame_ENST00000336755_ENST00000263228_TCGA-77-7338-11A_ZCCHC7_chr9_37126939_+_UBE2R2_chr9_33917015_length(amino acids)=218AA_start in transcript=106_stop in transcript=762
MMFGGYETIEAYEDDLYRDESSSELSVDSEVEFQLYSQIHYAQDLDDVIREEEHEEKNSGNSESSSSKPNQKKLIVLSDSEVIQLSDGSE
VITLSDEDSIYRCKGKNVRVQAQENAHGLSSSLQSNELVDKKCKSDIEKPKSEERSGVIREVMIIEVSSSEEEESTISEGDNVESWMLLG

--------------------------------------------------------------
>In-frame_ENST00000322831_ENST00000263228_TCGA-77-7338-11A_ZCCHC7_chr9_37126939_+_UBE2R2_chr9_33917015_length(transcript)=4263nt_BP=876nt
CCTGTTCGCAGCTGCGGCAGTGAGTATGTGTGTGACGGACCCCCGCCGCCCGCGGCTCGGGACCCCTGCCTACCCTCCTTCTTGCCCGCC
GGGCTGTGGAACTAGCGCGTGCCCCCTCGCCGGCCTCGACGTCTCCCGTCCGCCCCTCACTCGTGGCAGGGCGCAGCTCCTGGAGAATCT
GAGCATGGGGAATAAAGTCAGGAAGGATCGCAAGTGAGGATTATATTAATATGATAATTAGCACGCTTCAAGGTTACTGACTTTTTATGA
TGTTTGGTGGCTATGAGACTATAGAAGCATACGAAGATGATCTTTATCGAGATGAGTCATCTAGTGAACTGAGTGTTGATAGTGAGGTGG
AATTTCAACTCTATAGCCAAATTCATTATGCCCAAGATCTTGATGATGTCATCAGGGAGGAAGAGCATGAAGAAAAGAACTCTGGGAATT
CGGAATCTTCGAGTAGTAAACCAAATCAGAAGAAGCTAATCGTCCTTTCAGATAGTGAGGTCATCCAGCTGTCAGATGGGTCAGAGGTCA
TCACTTTGTCTGATGAAGACAGTATTTATAGATGTAAAGGAAAGAATGTTAGAGTTCAAGCACAAGAAAATGCCCATGGTCTTTCTTCTT
CTCTTCAATCTAATGAGCTGGTTGATAAGAAATGCAAGAGTGATATTGAGAAGCCTAAATCTGAAGAGAGATCAGGTGTAATCCGAGAGG
TCATGATTATAGAGGTCAGTTCAAGTGAAGAGGAAGAGAGCACCATTTCAGAAGGTGATAATGTGGAAAGCTGGATGCTACTGGGATGTG
AAGTAGATGATAAAGATGATGATATCCTTCTCAACCTTGTGGGATGTGAAAACTCTGTTACTGAAGGAAACAAGTTTCAGCCACTAAGGC
CGAAGCAGAAAAGGATGGAGTGAAGGTCCCCACAACCCTGGCGGAATACTGCATCAAAACTAAAGTGCCTTCCAATGACAACAGCTCAGA
TTTGCTTTACGACGACTTGTATGATGACGACATTGATGATGAAGATGAGGAGGAGGAAGATGCCGACTGTTATGATGATGATGATTCTGG
GAATGAGGAGTCGTGACGTGCTCCTTCAGTGCCCCTGTACTGCCCTGCCATCTCAGGCCAAAGGGAGGGGAGCAAGTGGGGACCTGGCCA
TGGCCCCTCAGCAAAAACCTATTCACAGCGGGTGGGGAAACACACACAGCTCCTGCTGACTCCCCTTATGGATCTCAGTTTGCTCCTTTT
TATGGACCTTTAATGGAGAGAGAGTAACCCTCCACAGAATGTCTGAATTCTTGCATTCTTTACCCTTCCATCACTATATTGATTCTTTTT
TTAAAAAATATGAACCCAAACTCCCGCCTCACTTCGTCTCTACAGAATGTTCACAGCAAAACACGTTTGGTCTGTTTTTAGATTCTTGAA
GAATTCAATAGTCTTTCAAGATGTTTAATGTGTTTAAAGCTGGGAACCTGTTGGGAGTTCACAAGTGCTGCATATACTGGGTAGCAAAAG
AAAATGGAAAAAAACCCACAAAACAAACTTTAAAAAAAAAAAAAAACAAATTTGCCAAGGTTTAGCTGCTCATTTACATTAGTGTGTGTG
CATTCGTTCAGCCCCATGGTGGTGAATTCTGTTTCTTTCCTTTCCTAAGGCTGGGACATGGTGGGCATCAGGGACTTTGTGCTAAGCCTG
ATGAAATGTGCTCCTTCAATCTCCATGAAACCATCGTAACATGGAGGCCTCAGCTGCTCTGAGGAGAGAAATCAGACTTTGTTTTTTGAA
ATCGATTGGGATCGAAAGCCTGAAATAAATATTCATACTTTCCATAGAACTGAGCACTTGGTTGCTATTTATTTTAAAGGCAGGGTTATT
TCCCCCCAGGGAGTGGGGCAAGCGGGGAAGTTGGGATGAGTGCGTGTGGGAGCAAAGAGTTAAAAATCACTATGCTAAGTTTGGTTGATG
CTACTGGGGGGAAAAAGTTGAAACTACTGGTGACCACTGTTGGGAGAGGAAACATCTGTTTTATAGATTTAGCATGGCCTTCCCATCAAA
AATACACTCGTACCATGACGTTTTGTTTTTGTTTTTTAAGTAGCCACTTTTAATTACTCAGTATTAATCCTAGGTGCATGTGTTAAGATT
TCGGTTTTCATCGAGCTGCTTATACTGATAGTGAAAAACTTGGATGTGTGTGAGACGAGTTACCGCCTTCTTCATTGGATGTGATCTGAA
CTTTTTTTCTCCTTTCAACATACTTAGGCTGTGGAGTGCAAGCAGAATTATGCATAGAAATTGTGGCAGGGCTGAGGGAGTTGACTGCAG
GCAGTTTTTAGGCCAGATAAGGCTAGATCTTCCTGCAATGCACTTGCTGCAGCTTTGATTTTCCAGATCTCAATCGTGTTGCTTCAATCA
ATATTGAGATCCAGCAGCCTTCACCATCCAGGAGACTTCAGAACTTGAAGGTAATTTTTGGTTGTTATGGGGGTGCACCAGATCATAGGA
GGGCATTATTTGGAGGAAACCGCTATAATGTAAAATCAGATTTCAGAAGGAAAATGCAGCAAGGACTGACTGTAGTCCTATTTCAGACCC
CTGGGCACTAGTGTCAACTCCTCCTTTGGCTCGTAACTCAGAAAGAACCAAAGGGCAGATTAGGGACGGGGCAGGAGGGATCCTAGGATG
GCCAGAGTAGGTGACGCTTACTTCCTTAGCTCCTCCTTCCATTCTGATCTCAGGGTTTTCACTCTTCAAACTCCCAAACACATGACTTCT
TCCCAGCAGCCCTTCCCGGCCTCTAAAGTTTGGTCCCAGCAGCCCTTCCCAGCCTCTAAAGTTTGGTCTGGTATGAAATGGGACTGTTTA
ACAAGCAAGGCTCTTAGGGGACACTGTTGAGCCTGGTCCCAGAATCTGTGATCTCCACAGGGCCAGGGTTGCTACTTGCACCCAGAATCT
AGTGATTTTAGTCAGATCCATGGAACAGAGCAGCTTCGTAATACATTGTCAAGTTACCTGATTACAAACTCTCATAGATGTTGGAACTAC
CTTTTTACTCCCCATACTTTGTAAGTAATGCTTCCAGATTAACCTGCAAATCTTGTGGAGCCAAAGCCTCTCACAGTGCTGATTTACCTC
CCCCAAAATGCCCCCAAACCCCCATGCAAGTTTACAGCCAGTAGCTTGGTCTTATTCTCTTGGAGCCCTAAAATTAAGCCTTTCATTCCC
CTTTGCTAAAGCATCTCACTCCCAGGGCAGCCCCAGCACCCTGGCATTGCGGGAGGTGCTCTGCTGCACAGCTGTTCCATCAGGCCCTAT
TGGCCTCTGTTAGACATTGACTCAGGGAGCCGGAGCGCCAAGTGGAGGTTGTACCTTTCAGCCCTTTGGGGTGTTAAAAGTGTCAAGGGC
TGGGTTTGCCTCTGATGAGTACAATCAGTTCCAGAAGACTGGGTAAGTCTCTTGCTAGCAGGTGGACATTCTGGTATTTTAGACTGACTG
AACGAAACCCAGAGGCTGGTTCCAGAGCTCTGTCCCTGAGAACACATCCCTGTGGAAAATACTTGAGTTTGTAATTTTTTTTCCCCCTTC
TGGGAGTGGAGGTCTCAGGCTCAATCCGGAACCATGTACGTACAGTTTTGCTTATTATTTGATGTGACATGAACTCAAAATCCTGCATTT
TTAGATTCCTTTTAGTTCTAATTGAGGCCTCACTAGATGCTCTTCAGTTCTGTGTATTTTGAGGCTGGGTGGAGAAGTATATGATTCTGC
TGTTGATTCTTTCAGTCTTCCCCCCTTCTCCTTTTATCAATCATTCCAGAGTTATTTTCTATTAGTCAAACTTTTTTGTAGAACCTTCTT
TCCCTTACCCTGGCAAATTGCTTCTTTACTTGCTGGTTTCCTTACGTTTGGGGCACATGTTGTAAGAAACTGATTGGAAGGGGAAATGTG
CAGCTCTCCACTGGAAAGGAACTCTCCACCCCTCCCATCCTGATAAAACAAACAAGGTTTACATTTACAACTAAAAGGATTCAGATGCAA
TTTTCAACTATTCTGAAACCAGCAGGACACACCTGACTTTAATAGTTTTAGCTGAAATTGTAGATGTTTTGCTTCAGTTTAACTTATGAG
AAAAGATTATCTGACGGATTTTGTGTTGACTTCCCCTTTAGTGGTTTATTTTGTCTTTTTCTGCCCATCTGTCTACTAATAAAATGTGAA

>In-frame_ENST00000322831_ENST00000263228_TCGA-77-7338-11A_ZCCHC7_chr9_37126939_+_UBE2R2_chr9_33917015_length(amino acids)=218AA_start in transcript=266_stop in transcript=922
MMFGGYETIEAYEDDLYRDESSSELSVDSEVEFQLYSQIHYAQDLDDVIREEEHEEKNSGNSESSSSKPNQKKLIVLSDSEVIQLSDGSE
VITLSDEDSIYRCKGKNVRVQAQENAHGLSSSLQSNELVDKKCKSDIEKPKSEERSGVIREVMIIEVSSSEEEESTISEGDNVESWMLLG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZCCHC7-UBE2R2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ZCCHC7-UBE2R2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ZCCHC7-UBE2R2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source