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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZDHHC20-KCNK1 (FusionGDB2 ID:100113)

Fusion Gene Summary for ZDHHC20-KCNK1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZDHHC20-KCNK1
Fusion gene ID: 100113
HgeneTgene
Gene symbol

ZDHHC20

KCNK1

Gene ID

253832

3775

Gene namezinc finger DHHC-type palmitoyltransferase 20potassium two pore domain channel subfamily K member 1
Synonyms4933421L13Rik|DHHC-20|DHHC20DPK|HOHO|K2P1|K2p1.1|KCNO1|TWIK-1|TWIK1
Cytomap

13q12.11

1q42.2

Type of geneprotein-codingprotein-coding
Descriptionpalmitoyltransferase ZDHHC20probable palmitoyltransferase ZDHHC20zinc finger DHHC domain-containing protein 20zinc finger DHHC-type containing 20potassium channel subfamily K member 1inward rectifying potassium channel protein TWIK-1potassium channel K2P1potassium channel KCNO1potassium channel, two pore domain subfamily K, member 1potassium inwardly-rectifying channel, subfamily K, member 1
Modification date2020031320200320
UniProtAcc.

Q96T54

Ensembl transtripts involved in fusion geneENST00000400590, ENST00000320220, 
ENST00000382466, ENST00000542645, 
ENST00000415724, ENST00000422251, 
ENST00000494731, 		ENST00000366621, 
ENST00000472190, ENST00000366620, 
Fusion gene scores* DoF score14 X 11 X 8=12326 X 3 X 5=90
# samples 166
** MAII scorelog2(16/1232*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZDHHC20 [Title/Abstract] AND KCNK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZDHHC20(21965861)-KCNK1(233802341), # samples:1
Anticipated loss of major functional domain due to fusion event.ZDHHC20-KCNK1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZDHHC20

GO:0018230

peptidyl-L-cysteine S-palmitoylation

29326245

HgeneZDHHC20

GO:0018345

protein palmitoylation

23034182

TgeneKCNK1

GO:0035725

sodium ion transmembrane transport

21653227

TgeneKCNK1

GO:0071805

potassium ion transmembrane transport

21653227|22282804


check buttonFusion gene breakpoints across ZDHHC20 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KCNK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A6TF-01AZDHHC20chr13

21965861

-KCNK1chr1

233802341

+


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Fusion Gene ORF analysis for ZDHHC20-KCNK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000400590ENST00000366621ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
5CDS-3UTRENST00000400590ENST00000472190ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
5CDS-3UTRENST00000400590ENST00000366620ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
Frame-shiftENST00000320220ENST00000366621ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
5CDS-3UTRENST00000320220ENST00000472190ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
5CDS-3UTRENST00000320220ENST00000366620ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
In-frameENST00000382466ENST00000366621ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
5CDS-3UTRENST00000382466ENST00000472190ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
5CDS-3UTRENST00000382466ENST00000366620ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
Frame-shiftENST00000542645ENST00000366621ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
5CDS-3UTRENST00000542645ENST00000472190ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
5CDS-3UTRENST00000542645ENST00000366620ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
In-frameENST00000415724ENST00000366621ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
5CDS-3UTRENST00000415724ENST00000472190ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
5CDS-3UTRENST00000415724ENST00000366620ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
intron-3CDSENST00000422251ENST00000366621ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
intron-3UTRENST00000422251ENST00000472190ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
intron-3UTRENST00000422251ENST00000366620ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
5UTR-3CDSENST00000494731ENST00000366621ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
5UTR-3UTRENST00000494731ENST00000472190ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+
5UTR-3UTRENST00000494731ENST00000366620ZDHHC20chr13

21965861

-KCNK1chr1

233802341

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000382466ZDHHC20chr1321965861-ENST00000366621KCNK1chr1233802341+2478840141495493
ENST00000415724ZDHHC20chr1321965861-ENST00000366621KCNK1chr1233802341+246983151486493

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382466ENST00000366621ZDHHC20chr1321965861-KCNK1chr1233802341+0.0002443410.9997557
ENST00000415724ENST00000366621ZDHHC20chr1321965861-KCNK1chr1233802341+0.0002395890.99976045

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Fusion Genomic Features for ZDHHC20-KCNK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZDHHC20chr1321965860-KCNK1chr1233802340+6.47E-091
ZDHHC20chr1321965860-KCNK1chr1233802340+6.47E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZDHHC20-KCNK1


check button Go to

FGviewer for the breakpoints of chr13:21965861-chr1:233802341

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KCNK1

Q96T54

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000382466-812126_176242.33333333333334355.0DomainDHHC
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000400590-813126_176242.33333333333334454.6666666666667DomainDHHC
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000415724-812126_176242.33333333333334366.0DomainDHHC
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000382466-812140_143242.33333333333334355.0RegionSubstrate binding
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000400590-813140_143242.33333333333334454.6666666666667RegionSubstrate binding
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000415724-812140_143242.33333333333334366.0RegionSubstrate binding
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000382466-812191_207242.33333333333334355.0Topological domainLumenal
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000382466-8121_14242.33333333333334355.0Topological domainCytoplasmic
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000382466-81236_53242.33333333333334355.0Topological domainLumenal
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000382466-81275_169242.33333333333334355.0Topological domainCytoplasmic
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000400590-813191_207242.33333333333334454.6666666666667Topological domainLumenal
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000400590-8131_14242.33333333333334454.6666666666667Topological domainCytoplasmic
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000400590-81336_53242.33333333333334454.6666666666667Topological domainLumenal
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000400590-81375_169242.33333333333334454.6666666666667Topological domainCytoplasmic
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000415724-812191_207242.33333333333334366.0Topological domainLumenal
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000415724-8121_14242.33333333333334366.0Topological domainCytoplasmic
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000415724-81236_53242.33333333333334366.0Topological domainLumenal
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000415724-81275_169242.33333333333334366.0Topological domainCytoplasmic
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000382466-81215_35242.33333333333334355.0TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000382466-812170_190242.33333333333334355.0TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000382466-812208_231242.33333333333334355.0TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000382466-81254_74242.33333333333334355.0TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000400590-81315_35242.33333333333334454.6666666666667TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000400590-813170_190242.33333333333334454.6666666666667TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000400590-813208_231242.33333333333334454.6666666666667TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000400590-81354_74242.33333333333334454.6666666666667TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000415724-81215_35242.33333333333334366.0TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000415724-812170_190242.33333333333334366.0TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000415724-812208_231242.33333333333334366.0TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000415724-81254_74242.33333333333334366.0TransmembraneHelical
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103212_224118.33333333333333337.0IntramembraneHelical%3B Name%3DPore helix 2
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103225_231118.33333333333333337.0IntramembraneOntology_term=ECO:0000269
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103117_122118.33333333333333337.0RegionSelectivity filter 1
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103225_230118.33333333333333337.0RegionSelectivity filter 2
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103293_299118.33333333333333337.0RegionImportant for intracellular retention in recycling endosomes
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103123_132118.33333333333333337.0Topological domainExtracellular
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103157_181118.33333333333333337.0Topological domainCytoplasmic
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103203_211118.33333333333333337.0Topological domainExtracellular
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103232_243118.33333333333333337.0Topological domainExtracellular
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103268_336118.33333333333333337.0Topological domainCytoplasmic
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103133_156118.33333333333333337.0TransmembraneHelical
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103182_202118.33333333333333337.0TransmembraneHelical
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103244_267118.33333333333333337.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000422251-15126_1760131.0DomainDHHC
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000422251-15140_1430131.0RegionSubstrate binding
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000382466-812232_365242.33333333333334355.0Topological domainCytoplasmic
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000400590-813232_365242.33333333333334454.6666666666667Topological domainCytoplasmic
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000415724-812232_365242.33333333333334366.0Topological domainCytoplasmic
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000422251-15191_2070131.0Topological domainLumenal
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000422251-151_140131.0Topological domainCytoplasmic
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000422251-15232_3650131.0Topological domainCytoplasmic
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000422251-1536_530131.0Topological domainLumenal
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000422251-1575_1690131.0Topological domainCytoplasmic
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000422251-1515_350131.0TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000422251-15170_1900131.0TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000422251-15208_2310131.0TransmembraneHelical
HgeneZDHHC20chr13:21965861chr1:233802341ENST00000422251-1554_740131.0TransmembraneHelical
TgeneKCNK1chr13:21965861chr1:233802341ENST0000036662103104_116118.33333333333333337.0IntramembraneHelical%3B Name%3DPore helix 1
TgeneKCNK1chr13:21965861chr1:233802341ENST00000366621031_20118.33333333333333337.0Topological domainCytoplasmic
TgeneKCNK1chr13:21965861chr1:233802341ENST000003666210342_103118.33333333333333337.0Topological domainExtracellular
TgeneKCNK1chr13:21965861chr1:233802341ENST000003666210321_41118.33333333333333337.0TransmembraneHelical


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Fusion Gene Sequence for ZDHHC20-KCNK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000382466_ENST00000366621_TCGA-FD-A6TF-01A_ZDHHC20_chr13_21965861_-_KCNK1_chr1_233802341_length(transcript)=2478nt_BP=840nt
CGGAGGCGGGGGAGCTGGACCAGCAGCCGCCTGGAGCGTCCGAGTCACCGTCGCCGGGGCTCCCGCGCTCCCCAGAACGGTGGGACGCGG
GGCTCGGCAGCCGCCAGCGGAACATGGCGCCCTGGACGCTGTGGCGCTGCTGCCAGCGCGTCGTGGGCTGGGTGCCGGTGCTCTTCATCA
CCTTCGTGGTCGTCTGGTCCTACTACGCGTACGTGGTGGAGCTCTGCGTGTTTACTATTTTTGGAAATGAAGAAAATGGAAAGACCGTTG
TTTACCTTGTGGCTTTCCATCTGTTCTTTGTTATGTTTGTATGGTCCTATTGGATGACAATTTTCACATCTCCCGCTTCCCCCTCCAAAG
AGTTCTACTTGTCCAATTCTGAAAAGGAACGTTATGAAAAAGAATTCAGCCAAGAAAGACAACAAGAAATTTTGAGAAGAGCAGCAAGAG
CTTTACCTATCTATACCACATCAGCTTCAAAAACTATCAGATATTGTGAAAAATGTCAGCTGATTAAACCTGATCGGGCGCATCACTGCT
CAGCCTGTGACTCATGTATTCTTAAGATGGATCATCACTGTCCTTGGGTGAATAACTGTGTGGGATTTTCTAATTACAAATTCTTCCTGC
TGTTTTTATTGTATTCCCTATTATATTGCCTTTTCGTGGCTGCAACAGTTTTAGAGTACTTTATAAAATTTTGGACGAATGAACTGACAG
ATACACGTGCAAAATTCCACGTACTTTTTCTTTTCTTTGTGTCTGCAATGTTCTTCATCAGCGTCCTCTCACTTTTCAGCTACCACTGCT
GGCTAGTTGGAAAAAATAGAACAACAATAGGTTATGGCCACACCGTGCCCTTGTCAGATGGAGGTAAGGCCTTCTGCATCATCTACTCCG
TCATTGGCATTCCCTTCACCCTCCTGTTCCTGACGGCTGTGGTCCAGCGCATCACCGTGCACGTCACCCGCAGGCCGGTCCTCTACTTCC
ACATCCGCTGGGGCTTCTCCAAGCAGGTGGTGGCCATCGTCCATGCCGTGCTCCTTGGGTTTGTCACTGTGTCCTGCTTCTTCTTCATCC
CGGCCGCTGTCTTCTCAGTCCTGGAGGATGACTGGAACTTCCTGGAATCCTTTTATTTTTGTTTTATTTCCCTGAGCACCATTGGCCTGG
GGGATTATGTGCCTGGGGAAGGCTACAATCAAAAATTCAGAGAGCTCTATAAGATTGGGATCACGTGTTACCTGCTACTTGGCCTTATTG
CCATGTTGGTAGTTCTGGAAACCTTCTGTGAACTCCATGAGCTGAAAAAATTCAGAAAAATGTTCTATGTGAAGAAGGACAAGGACGAGG
ATCAGGTGCACATCATAGAGCATGACCAACTGTCCTTCTCCTCGATCACAGACCAGGCAGCTGGCATGAAAGAGGACCAGAAGCAAAATG
AGCCTTTTGTGGCCACCCAGTCATCTGCCTGCGTGGATGGCCCTGCAAACCATTGAGCGTAGGATTTGTTGCATTATGCTAGAGCACCAG
GGTCAGGGTGCAAGGAAGAGGCTTAAGTATGTTCATTTTTATCAGAATGCAAAAGCGAAAATTATGTCACTTTAAGAAATAGCTACTGTT
TGCAATGTCTTATTAAAAAACAACAAAAAAAGACAAATGGAACAAAGAAGCTGTGACCCCAGCAGGATGTCTAATATGTGAGGAAATGAG
ATGTCCACCTAAAATTCATATGTGACAAAATTATCTCGACCTTACATAGGAGGAGAATACTTGAAGCAGTATGCTGCTGTGGTTAGAAGC
AGATTTTATACTTTTAACTGGAAACTTTGGGGTTTGCATTTAGATCATTTAGCTGATGGCTAAATAGCAAAATTTATATTTAGAAGCAAA
AAAAAAAAGCATAGAGATGTGTTTTATAAATAGGTTTATGTGTACTGGTTTGCATGTACCCACCCAAAATGATTATTTTTGTAGAATCTA
AGTTAAACTTACTATTTATAATGCATAGGTAACCATTAACTATGTACATATAAAGTATAAATATGTTTATATTCTGTACATATGGTTTAG
GTCACCAGATCCTAGTGTAGTTCTGAAACTAAGACTATAGATATTTTGTTTCTTTTGATTTCTCTTTATACTAAAGAATCCAGAGTTGCT
ACAATAAAATAAGGGGAATAATAAACTTGAGAGTGAATAACCATAGTATTCTGCTGCAATAAATGTTTCTACCCTCTTGCGATAGAATGG
TGTCAGATGTCTAACATGTTTATAAACATTTTTTTGAATTGAACAGGTTATGAAAAGGATTTATTAAAAGGTTAAGATACTTTGTTTTGA
AAGTACATTGTGATTTGCAGCCACCTAGCACTAAAGCATAGAACTTAAACACGAATCCCTAAATGAACAGATTATGTTACATTAATCTGA

>In-frame_ENST00000382466_ENST00000366621_TCGA-FD-A6TF-01A_ZDHHC20_chr13_21965861_-_KCNK1_chr1_233802341_length(amino acids)=493AA_start in transcript=14_stop in transcript=1495
MDQQPPGASESPSPGLPRSPERWDAGLGSRQRNMAPWTLWRCCQRVVGWVPVLFITFVVVWSYYAYVVELCVFTIFGNEENGKTVVYLVA
FHLFFVMFVWSYWMTIFTSPASPSKEFYLSNSEKERYEKEFSQERQQEILRRAARALPIYTTSASKTIRYCEKCQLIKPDRAHHCSACDS
CILKMDHHCPWVNNCVGFSNYKFFLLFLLYSLLYCLFVAATVLEYFIKFWTNELTDTRAKFHVLFLFFVSAMFFISVLSLFSYHCWLVGK
NRTTIGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVF
SVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHI

--------------------------------------------------------------
>In-frame_ENST00000415724_ENST00000366621_TCGA-FD-A6TF-01A_ZDHHC20_chr13_21965861_-_KCNK1_chr1_233802341_length(transcript)=2469nt_BP=831nt
GGGAGCTGGACCAGCAGCCGCCTGGAGCGTCCGAGTCACCGTCGCCGGGGCTCCCGCGCTCCCCAGAACGGTGGGACGCGGGGCTCGGCA
GCCGCCAGCGGAACATGGCGCCCTGGACGCTGTGGCGCTGCTGCCAGCGCGTCGTGGGCTGGGTGCCGGTGCTCTTCATCACCTTCGTGG
TCGTCTGGTCCTACTACGCGTACGTGGTGGAGCTCTGCGTGTTTACTATTTTTGGAAATGAAGAAAATGGAAAGACCGTTGTTTACCTTG
TGGCTTTCCATCTGTTCTTTGTTATGTTTGTATGGTCCTATTGGATGACAATTTTCACATCTCCCGCTTCCCCCTCCAAAGAGTTCTACT
TGTCCAATTCTGAAAAGGAACGTTATGAAAAAGAATTCAGCCAAGAAAGACAACAAGAAATTTTGAGAAGAGCAGCAAGAGCTTTACCTA
TCTATACCACATCAGCTTCAAAAACTATCAGATATTGTGAAAAATGTCAGCTGATTAAACCTGATCGGGCGCATCACTGCTCAGCCTGTG
ACTCATGTATTCTTAAGATGGATCATCACTGTCCTTGGGTGAATAACTGTGTGGGATTTTCTAATTACAAATTCTTCCTGCTGTTTTTAT
TGTATTCCCTATTATATTGCCTTTTCGTGGCTGCAACAGTTTTAGAGTACTTTATAAAATTTTGGACGAATGAACTGACAGATACACGTG
CAAAATTCCACGTACTTTTTCTTTTCTTTGTGTCTGCAATGTTCTTCATCAGCGTCCTCTCACTTTTCAGCTACCACTGCTGGCTAGTTG
GAAAAAATAGAACAACAATAGGTTATGGCCACACCGTGCCCTTGTCAGATGGAGGTAAGGCCTTCTGCATCATCTACTCCGTCATTGGCA
TTCCCTTCACCCTCCTGTTCCTGACGGCTGTGGTCCAGCGCATCACCGTGCACGTCACCCGCAGGCCGGTCCTCTACTTCCACATCCGCT
GGGGCTTCTCCAAGCAGGTGGTGGCCATCGTCCATGCCGTGCTCCTTGGGTTTGTCACTGTGTCCTGCTTCTTCTTCATCCCGGCCGCTG
TCTTCTCAGTCCTGGAGGATGACTGGAACTTCCTGGAATCCTTTTATTTTTGTTTTATTTCCCTGAGCACCATTGGCCTGGGGGATTATG
TGCCTGGGGAAGGCTACAATCAAAAATTCAGAGAGCTCTATAAGATTGGGATCACGTGTTACCTGCTACTTGGCCTTATTGCCATGTTGG
TAGTTCTGGAAACCTTCTGTGAACTCCATGAGCTGAAAAAATTCAGAAAAATGTTCTATGTGAAGAAGGACAAGGACGAGGATCAGGTGC
ACATCATAGAGCATGACCAACTGTCCTTCTCCTCGATCACAGACCAGGCAGCTGGCATGAAAGAGGACCAGAAGCAAAATGAGCCTTTTG
TGGCCACCCAGTCATCTGCCTGCGTGGATGGCCCTGCAAACCATTGAGCGTAGGATTTGTTGCATTATGCTAGAGCACCAGGGTCAGGGT
GCAAGGAAGAGGCTTAAGTATGTTCATTTTTATCAGAATGCAAAAGCGAAAATTATGTCACTTTAAGAAATAGCTACTGTTTGCAATGTC
TTATTAAAAAACAACAAAAAAAGACAAATGGAACAAAGAAGCTGTGACCCCAGCAGGATGTCTAATATGTGAGGAAATGAGATGTCCACC
TAAAATTCATATGTGACAAAATTATCTCGACCTTACATAGGAGGAGAATACTTGAAGCAGTATGCTGCTGTGGTTAGAAGCAGATTTTAT
ACTTTTAACTGGAAACTTTGGGGTTTGCATTTAGATCATTTAGCTGATGGCTAAATAGCAAAATTTATATTTAGAAGCAAAAAAAAAAAG
CATAGAGATGTGTTTTATAAATAGGTTTATGTGTACTGGTTTGCATGTACCCACCCAAAATGATTATTTTTGTAGAATCTAAGTTAAACT
TACTATTTATAATGCATAGGTAACCATTAACTATGTACATATAAAGTATAAATATGTTTATATTCTGTACATATGGTTTAGGTCACCAGA
TCCTAGTGTAGTTCTGAAACTAAGACTATAGATATTTTGTTTCTTTTGATTTCTCTTTATACTAAAGAATCCAGAGTTGCTACAATAAAA
TAAGGGGAATAATAAACTTGAGAGTGAATAACCATAGTATTCTGCTGCAATAAATGTTTCTACCCTCTTGCGATAGAATGGTGTCAGATG
TCTAACATGTTTATAAACATTTTTTTGAATTGAACAGGTTATGAAAAGGATTTATTAAAAGGTTAAGATACTTTGTTTTGAAAGTACATT
GTGATTTGCAGCCACCTAGCACTAAAGCATAGAACTTAAACACGAATCCCTAAATGAACAGATTATGTTACATTAATCTGAGAATTTTAA

>In-frame_ENST00000415724_ENST00000366621_TCGA-FD-A6TF-01A_ZDHHC20_chr13_21965861_-_KCNK1_chr1_233802341_length(amino acids)=493AA_start in transcript=5_stop in transcript=1486
MDQQPPGASESPSPGLPRSPERWDAGLGSRQRNMAPWTLWRCCQRVVGWVPVLFITFVVVWSYYAYVVELCVFTIFGNEENGKTVVYLVA
FHLFFVMFVWSYWMTIFTSPASPSKEFYLSNSEKERYEKEFSQERQQEILRRAARALPIYTTSASKTIRYCEKCQLIKPDRAHHCSACDS
CILKMDHHCPWVNNCVGFSNYKFFLLFLLYSLLYCLFVAATVLEYFIKFWTNELTDTRAKFHVLFLFFVSAMFFISVLSLFSYHCWLVGK
NRTTIGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRITVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVF
SVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHI

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Fusion Gene PPI Analysis for ZDHHC20-KCNK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZDHHC20-KCNK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZDHHC20-KCNK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKCNK1C0020507Hyperplasia1CTD_human