|
Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:ZEB1-B2M (FusionGDB2 ID:100170) |
Fusion Gene Summary for ZEB1-B2M |
Fusion gene summary |
Fusion gene information | Fusion gene name: ZEB1-B2M | Fusion gene ID: 100170 | Hgene | Tgene | Gene symbol | ZEB1 | B2M | Gene ID | 6935 | 567 |
Gene name | zinc finger E-box binding homeobox 1 | beta-2-microglobulin | |
Synonyms | AREB6|BZP|DELTAEF1|FECD6|NIL2A|PPCD3|TCF8|ZFHEP|ZFHX1A | IMD43 | |
Cytomap | 10p11.22 | 15q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger E-box-binding homeobox 1delta-crystallin enhancer binding factor 1negative regulator of IL2posterior polymorphous corneal dystrophy 3transcription factor 8 (represses interleukin 2 expression)zinc finger homeodomain enhancer-binding prote | beta-2-microglobulinbeta chain of MHC class I moleculesbeta-2-microglobin | |
Modification date | 20200329 | 20200329 | |
UniProtAcc | . | P61769 | |
Ensembl transtripts involved in fusion gene | ENST00000320985, ENST00000361642, ENST00000559858, ENST00000560721, ENST00000542815, ENST00000446923, | ENST00000558401, ENST00000559916, ENST00000544417, ENST00000559220, | |
Fusion gene scores | * DoF score | 11 X 5 X 8=440 | 64 X 31 X 17=33728 |
# samples | 13 | 71 | |
** MAII score | log2(13/440*10)=-1.7589919004962 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(71/33728*10)=-5.56998393724517 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZEB1 [Title/Abstract] AND B2M [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ZEB1(31608221)-B2M(45007621), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ZEB1-B2M seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. ZEB1-B2M seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ZEB1-B2M seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ZEB1-B2M seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ZEB1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 23765923|23814079 |
Hgene | ZEB1 | GO:0045892 | negative regulation of transcription, DNA-templated | 20418909 |
Tgene | B2M | GO:0002726 | positive regulation of T cell cytokine production | 24643698 |
Tgene | B2M | GO:0007611 | learning or memory | 26147761 |
Tgene | B2M | GO:0050680 | negative regulation of epithelial cell proliferation | 28213472 |
Tgene | B2M | GO:0050768 | negative regulation of neurogenesis | 26147761 |
Tgene | B2M | GO:0090647 | modulation of age-related behavioral decline | 26147761 |
Tgene | B2M | GO:1900121 | negative regulation of receptor binding | 9465039 |
Tgene | B2M | GO:1990000 | amyloid fibril formation | 28468825 |
Tgene | B2M | GO:2000774 | positive regulation of cellular senescence | 28213472 |
Tgene | B2M | GO:2000978 | negative regulation of forebrain neuron differentiation | 26147761 |
Fusion gene breakpoints across ZEB1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across B2M (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | UCEC | TCGA-EO-A3AV-01A | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
Top |
Fusion Gene ORF analysis for ZEB1-B2M |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000320985 | ENST00000558401 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
In-frame | ENST00000320985 | ENST00000559916 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
Frame-shift | ENST00000320985 | ENST00000544417 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
5CDS-intron | ENST00000320985 | ENST00000559220 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
In-frame | ENST00000361642 | ENST00000558401 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
In-frame | ENST00000361642 | ENST00000559916 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
Frame-shift | ENST00000361642 | ENST00000544417 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
5CDS-intron | ENST00000361642 | ENST00000559220 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
3UTR-3CDS | ENST00000559858 | ENST00000558401 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
3UTR-3CDS | ENST00000559858 | ENST00000559916 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
3UTR-3CDS | ENST00000559858 | ENST00000544417 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
3UTR-intron | ENST00000559858 | ENST00000559220 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
In-frame | ENST00000560721 | ENST00000558401 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
In-frame | ENST00000560721 | ENST00000559916 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
Frame-shift | ENST00000560721 | ENST00000544417 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
5CDS-intron | ENST00000560721 | ENST00000559220 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
In-frame | ENST00000542815 | ENST00000558401 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
In-frame | ENST00000542815 | ENST00000559916 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
Frame-shift | ENST00000542815 | ENST00000544417 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
5CDS-intron | ENST00000542815 | ENST00000559220 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
intron-3CDS | ENST00000446923 | ENST00000558401 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
intron-3CDS | ENST00000446923 | ENST00000559916 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
intron-3CDS | ENST00000446923 | ENST00000544417 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
intron-intron | ENST00000446923 | ENST00000559220 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000320985 | ZEB1 | chr10 | 31608221 | + | ENST00000558401 | B2M | chr15 | 45007621 | + | 1746 | 168 | 110 | 460 | 116 |
ENST00000320985 | ZEB1 | chr10 | 31608221 | + | ENST00000559916 | B2M | chr15 | 45007621 | + | 1148 | 168 | 110 | 460 | 116 |
ENST00000361642 | ZEB1 | chr10 | 31608221 | + | ENST00000558401 | B2M | chr15 | 45007621 | + | 1699 | 121 | 63 | 413 | 116 |
ENST00000361642 | ZEB1 | chr10 | 31608221 | + | ENST00000559916 | B2M | chr15 | 45007621 | + | 1101 | 121 | 63 | 413 | 116 |
ENST00000560721 | ZEB1 | chr10 | 31608221 | + | ENST00000558401 | B2M | chr15 | 45007621 | + | 1659 | 81 | 23 | 373 | 116 |
ENST00000560721 | ZEB1 | chr10 | 31608221 | + | ENST00000559916 | B2M | chr15 | 45007621 | + | 1061 | 81 | 23 | 373 | 116 |
ENST00000542815 | ZEB1 | chr10 | 31608221 | + | ENST00000558401 | B2M | chr15 | 45007621 | + | 1649 | 71 | 13 | 363 | 116 |
ENST00000542815 | ZEB1 | chr10 | 31608221 | + | ENST00000559916 | B2M | chr15 | 45007621 | + | 1051 | 71 | 13 | 363 | 116 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000320985 | ENST00000558401 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + | 0.007904012 | 0.99209595 |
ENST00000320985 | ENST00000559916 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + | 0.010580252 | 0.9894197 |
ENST00000361642 | ENST00000558401 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + | 0.011605597 | 0.9883944 |
ENST00000361642 | ENST00000559916 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + | 0.012969508 | 0.98703045 |
ENST00000560721 | ENST00000558401 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + | 0.011545502 | 0.9884545 |
ENST00000560721 | ENST00000559916 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + | 0.02100591 | 0.97899413 |
ENST00000542815 | ENST00000558401 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + | 0.011296582 | 0.9887034 |
ENST00000542815 | ENST00000559916 | ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007621 | + | 0.017207075 | 0.98279285 |
Top |
Fusion Genomic Features for ZEB1-B2M |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007620 | + | 4.05E-05 | 0.99995947 |
ZEB1 | chr10 | 31608221 | + | B2M | chr15 | 45007620 | + | 4.05E-05 | 0.99995947 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for ZEB1-B2M |
Go to FGviewer for the breakpoints of chr10:31608221-chr15:45007621 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | B2M |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553). {ECO:0000269|PubMed:25356553}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | B2M | chr10:31608221 | chr15:45007621 | ENST00000558401 | 0 | 4 | 25_113 | 22.333333333333332 | 498.0 | Domain | Note=Ig-like C1-type | |
Tgene | B2M | chr10:31608221 | chr15:45007621 | ENST00000559916 | 0 | 3 | 25_113 | 22.333333333333332 | 120.0 | Domain | Note=Ig-like C1-type |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000320985 | + | 1 | 9 | 989_1124 | 19.333333333333332 | 1125.0 | Compositional bias | Note=Glu-rich (acidic) |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000361642 | + | 1 | 9 | 989_1124 | 19.333333333333332 | 1126.0 | Compositional bias | Note=Glu-rich (acidic) |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000446923 | + | 1 | 9 | 989_1124 | 0 | 1109.0 | Compositional bias | Note=Glu-rich (acidic) |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000542815 | + | 1 | 8 | 989_1124 | 19.333333333333332 | 1058.0 | Compositional bias | Note=Glu-rich (acidic) |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000560721 | + | 1 | 8 | 989_1124 | 19.333333333333332 | 1105.0 | Compositional bias | Note=Glu-rich (acidic) |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000320985 | + | 1 | 9 | 581_640 | 19.333333333333332 | 1125.0 | DNA binding | Note=Homeobox%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000361642 | + | 1 | 9 | 581_640 | 19.333333333333332 | 1126.0 | DNA binding | Note=Homeobox%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000446923 | + | 1 | 9 | 581_640 | 0 | 1109.0 | DNA binding | Note=Homeobox%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000542815 | + | 1 | 8 | 581_640 | 19.333333333333332 | 1058.0 | DNA binding | Note=Homeobox%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000560721 | + | 1 | 8 | 581_640 | 19.333333333333332 | 1105.0 | DNA binding | Note=Homeobox%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000320985 | + | 1 | 9 | 170_193 | 19.333333333333332 | 1125.0 | Zinc finger | C2H2-type 1 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000320985 | + | 1 | 9 | 200_222 | 19.333333333333332 | 1125.0 | Zinc finger | C2H2-type 2 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000320985 | + | 1 | 9 | 240_262 | 19.333333333333332 | 1125.0 | Zinc finger | C2H2-type 3 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000320985 | + | 1 | 9 | 268_292 | 19.333333333333332 | 1125.0 | Zinc finger | C2H2-type 4%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000320985 | + | 1 | 9 | 904_926 | 19.333333333333332 | 1125.0 | Zinc finger | C2H2-type 5 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000320985 | + | 1 | 9 | 932_954 | 19.333333333333332 | 1125.0 | Zinc finger | C2H2-type 6 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000320985 | + | 1 | 9 | 960_981 | 19.333333333333332 | 1125.0 | Zinc finger | C2H2-type 7%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000361642 | + | 1 | 9 | 170_193 | 19.333333333333332 | 1126.0 | Zinc finger | C2H2-type 1 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000361642 | + | 1 | 9 | 200_222 | 19.333333333333332 | 1126.0 | Zinc finger | C2H2-type 2 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000361642 | + | 1 | 9 | 240_262 | 19.333333333333332 | 1126.0 | Zinc finger | C2H2-type 3 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000361642 | + | 1 | 9 | 268_292 | 19.333333333333332 | 1126.0 | Zinc finger | C2H2-type 4%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000361642 | + | 1 | 9 | 904_926 | 19.333333333333332 | 1126.0 | Zinc finger | C2H2-type 5 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000361642 | + | 1 | 9 | 932_954 | 19.333333333333332 | 1126.0 | Zinc finger | C2H2-type 6 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000361642 | + | 1 | 9 | 960_981 | 19.333333333333332 | 1126.0 | Zinc finger | C2H2-type 7%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000446923 | + | 1 | 9 | 170_193 | 0 | 1109.0 | Zinc finger | C2H2-type 1 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000446923 | + | 1 | 9 | 200_222 | 0 | 1109.0 | Zinc finger | C2H2-type 2 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000446923 | + | 1 | 9 | 240_262 | 0 | 1109.0 | Zinc finger | C2H2-type 3 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000446923 | + | 1 | 9 | 268_292 | 0 | 1109.0 | Zinc finger | C2H2-type 4%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000446923 | + | 1 | 9 | 904_926 | 0 | 1109.0 | Zinc finger | C2H2-type 5 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000446923 | + | 1 | 9 | 932_954 | 0 | 1109.0 | Zinc finger | C2H2-type 6 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000446923 | + | 1 | 9 | 960_981 | 0 | 1109.0 | Zinc finger | C2H2-type 7%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000542815 | + | 1 | 8 | 170_193 | 19.333333333333332 | 1058.0 | Zinc finger | C2H2-type 1 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000542815 | + | 1 | 8 | 200_222 | 19.333333333333332 | 1058.0 | Zinc finger | C2H2-type 2 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000542815 | + | 1 | 8 | 240_262 | 19.333333333333332 | 1058.0 | Zinc finger | C2H2-type 3 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000542815 | + | 1 | 8 | 268_292 | 19.333333333333332 | 1058.0 | Zinc finger | C2H2-type 4%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000542815 | + | 1 | 8 | 904_926 | 19.333333333333332 | 1058.0 | Zinc finger | C2H2-type 5 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000542815 | + | 1 | 8 | 932_954 | 19.333333333333332 | 1058.0 | Zinc finger | C2H2-type 6 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000542815 | + | 1 | 8 | 960_981 | 19.333333333333332 | 1058.0 | Zinc finger | C2H2-type 7%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000560721 | + | 1 | 8 | 170_193 | 19.333333333333332 | 1105.0 | Zinc finger | C2H2-type 1 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000560721 | + | 1 | 8 | 200_222 | 19.333333333333332 | 1105.0 | Zinc finger | C2H2-type 2 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000560721 | + | 1 | 8 | 240_262 | 19.333333333333332 | 1105.0 | Zinc finger | C2H2-type 3 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000560721 | + | 1 | 8 | 268_292 | 19.333333333333332 | 1105.0 | Zinc finger | C2H2-type 4%3B atypical |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000560721 | + | 1 | 8 | 904_926 | 19.333333333333332 | 1105.0 | Zinc finger | C2H2-type 5 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000560721 | + | 1 | 8 | 932_954 | 19.333333333333332 | 1105.0 | Zinc finger | C2H2-type 6 |
Hgene | ZEB1 | chr10:31608221 | chr15:45007621 | ENST00000560721 | + | 1 | 8 | 960_981 | 19.333333333333332 | 1105.0 | Zinc finger | C2H2-type 7%3B atypical |
Top |
Fusion Gene Sequence for ZEB1-B2M |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000320985_ENST00000558401_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(transcript)=1746nt_BP=168nt GTAAACCAGGTGCGGTGGGGAGGGGGGAGGGGTGGAGGCGGAGGGGTGGGGGGGAAGGGGGAGGGAGGGGGAGGAGGTGACTCGAGCATT TAGACACAAGCGAGAGGATCATGGCGGATGGCCCCAGGTGTAAGCGCAGAAAGCAGGCGAACCCGCGGCGCAATAACGGTACTCCAAAGA TTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAG TTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACT ACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATC GAGACATGTAAGCAGCATCATGGAGGTTTGAAGATGCCGCATTTGGATTGGATGAATTCCAAATTCTGCTTGCTTGCTTTTTAATATTGA TATGCTTATACACTTACACTTTATGCACAAAATGTAGGGTTATAATAATGTTAACATGGACATGATCTTCTTTATAATTCTACTTTGAGT GCTGTCTCCATGTTTGATGTATCTGAGCAGGTTGCTCCACAGGTAGCTCTAGGAGGGCTGGCAACTTAGAGGTGGGGAGCAGAGAATTCT CTTATCCAACATCAACATCTTGGTCAGATTTGAACTCTTCAATCTCTTGCACTCAAAGCTTGTTAAGATAGTTAAGCGTGCATAAGTTAA CTTCCAATTTACATACTCTGCTTAGAATTTGGGGGAAAATTTAGAAATATAATTGACAGGATTATTGGAAATTTGTTATAATGAATGAAA CATTTTGTCATATAAGATTCATATTTACTTCTTATACATTTGATAAAGTAAGGCATGGTTGTGGTTAATCTGGTTTATTTTTGTTCCACA AGTTAAATAAATCATAAAACTTGATGTGTTATCTCTTATATCTCACTCCCACTATTACCCCTTTATTTTCAAACAGGGAAACAGTCTTCA AGTTCCACTTGGTAAAAAATGTGAACCCCTTGTATATAGAGTTTGGCTCACAGTGTAAAGGGCCTCAGTGATTCACATTTTCCAGATTAG GAATCTGATGCTCAAAGAAGTTAAATGGCATAGTTGGGGTGACACAGCTGTCTAGTGGGAGGCCAGCCTTCTATATTTTAGCCAGCGTTC TTTCCTGCGGGCCAGGTCATGAGGAGTATGCAGACTCTAAGAGGGAGCAAAAGTATCTGAAGGATTTAATATTTTAGCAAGGAATAGATA TACAATCATCCCTTGGTCTCCCTGGGGGATTGGTTTCAGGACCCCTTCTTGGACACCAAATCTATGGATATTTAAGTCCCTTCTATAAAA TGGTATAGTATTTGCATATAACCTATCCACATCCTCCTGTATACTTTAAATCATTTCTAGATTACTTGTAATACCTAATACAATGTAAAT GCTATGCAAATAGTTGTTATTGTTTAAGGAATAATGACAAGAAAAAAAAGTCTGTACATGCTCAGTAAAGACACAACCATCCCTTTTTTT CCCCAGTGTTTTTGATCCATGGTTTGCTGAATCCACAGATGTGGAGCCCCTGGATACGGAAGGCCCGCTGTACTTTGAATGACAAATAAC >In-frame_ENST00000320985_ENST00000558401_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(amino acids)=116AA_start in transcript=110_stop in transcript=460 MADGPRCKRRKQANPRRNNGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPT -------------------------------------------------------------- >In-frame_ENST00000320985_ENST00000559916_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(transcript)=1148nt_BP=168nt GTAAACCAGGTGCGGTGGGGAGGGGGGAGGGGTGGAGGCGGAGGGGTGGGGGGGAAGGGGGAGGGAGGGGGAGGAGGTGACTCGAGCATT TAGACACAAGCGAGAGGATCATGGCGGATGGCCCCAGGTGTAAGCGCAGAAAGCAGGCGAACCCGCGGCGCAATAACGGTACTCCAAAGA TTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAG TTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACT ACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATC GAGACATGTAAGCAGCATCATGGAGGTAAGTTTTTGACCTTGAGAAAATGTTTTTGTTTCACTGTCCTGAGGACTATTTATAGACAGCTC TAACATGATAACCCTCACTATGTGGAGAACATTGACAGAGTAACATTTTAGCAGGGAAAGAAGAATCCTACAGGGTCATGTTCCCTTCTC CTGTGGAGTGGCATGAAGAAGGTGTATGGCCCCAGGTATGGCCATATTACTGACCCTCTACAGAGAGGGCAAAGGAACTGCCAGTATGGT ATTGCAGGATAAAGGCAGGTGGTTACCCACATTACCTGCAAGGCTTTGATCTTTCTTCTGCCATTTCCACATTGGACATCTCTGCTGAGG AGAGAAAATGAACCACTCTTTTCCTTTGTATAATGTTGTTTTATTCTTCAGACAGAAGAGAGGAGTTATACAGCTCTGCAGACATCCCAT TCCTGTATGGGGACTGTGTTTGCCTCTTAGAGGTTCCCAGGCCACTAGAGGAGATAAAGGGAAACAGATTGTTATAACTTGATATAATGA TACTATAATAGATGTAACTACAAGGAGCTCCAGAAGCAAGAGAGAGGGAGGAACTTGGACTTCTCTGCATCTTTAGTTGGAGTCCAAAGG >In-frame_ENST00000320985_ENST00000559916_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(amino acids)=116AA_start in transcript=110_stop in transcript=460 MADGPRCKRRKQANPRRNNGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPT -------------------------------------------------------------- >In-frame_ENST00000361642_ENST00000558401_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(transcript)=1699nt_BP=121nt GGGGGGGAAGGGGGAGGGAGGGGGAGGAGGTGACTCGAGCATTTAGACACAAGCGAGAGGATCATGGCGGATGGCCCCAGGTGTAAGCGC AGAAAGCAGGCGAACCCGCGGCGCAATAACGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTC CTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCA GACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTG AACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATGGAGGTTTGAAGATGCCGCATTTGGA TTGGATGAATTCCAAATTCTGCTTGCTTGCTTTTTAATATTGATATGCTTATACACTTACACTTTATGCACAAAATGTAGGGTTATAATA ATGTTAACATGGACATGATCTTCTTTATAATTCTACTTTGAGTGCTGTCTCCATGTTTGATGTATCTGAGCAGGTTGCTCCACAGGTAGC TCTAGGAGGGCTGGCAACTTAGAGGTGGGGAGCAGAGAATTCTCTTATCCAACATCAACATCTTGGTCAGATTTGAACTCTTCAATCTCT TGCACTCAAAGCTTGTTAAGATAGTTAAGCGTGCATAAGTTAACTTCCAATTTACATACTCTGCTTAGAATTTGGGGGAAAATTTAGAAA TATAATTGACAGGATTATTGGAAATTTGTTATAATGAATGAAACATTTTGTCATATAAGATTCATATTTACTTCTTATACATTTGATAAA GTAAGGCATGGTTGTGGTTAATCTGGTTTATTTTTGTTCCACAAGTTAAATAAATCATAAAACTTGATGTGTTATCTCTTATATCTCACT CCCACTATTACCCCTTTATTTTCAAACAGGGAAACAGTCTTCAAGTTCCACTTGGTAAAAAATGTGAACCCCTTGTATATAGAGTTTGGC TCACAGTGTAAAGGGCCTCAGTGATTCACATTTTCCAGATTAGGAATCTGATGCTCAAAGAAGTTAAATGGCATAGTTGGGGTGACACAG CTGTCTAGTGGGAGGCCAGCCTTCTATATTTTAGCCAGCGTTCTTTCCTGCGGGCCAGGTCATGAGGAGTATGCAGACTCTAAGAGGGAG CAAAAGTATCTGAAGGATTTAATATTTTAGCAAGGAATAGATATACAATCATCCCTTGGTCTCCCTGGGGGATTGGTTTCAGGACCCCTT CTTGGACACCAAATCTATGGATATTTAAGTCCCTTCTATAAAATGGTATAGTATTTGCATATAACCTATCCACATCCTCCTGTATACTTT AAATCATTTCTAGATTACTTGTAATACCTAATACAATGTAAATGCTATGCAAATAGTTGTTATTGTTTAAGGAATAATGACAAGAAAAAA AAGTCTGTACATGCTCAGTAAAGACACAACCATCCCTTTTTTTCCCCAGTGTTTTTGATCCATGGTTTGCTGAATCCACAGATGTGGAGC >In-frame_ENST00000361642_ENST00000558401_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(amino acids)=116AA_start in transcript=63_stop in transcript=413 MADGPRCKRRKQANPRRNNGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPT -------------------------------------------------------------- >In-frame_ENST00000361642_ENST00000559916_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(transcript)=1101nt_BP=121nt GGGGGGGAAGGGGGAGGGAGGGGGAGGAGGTGACTCGAGCATTTAGACACAAGCGAGAGGATCATGGCGGATGGCCCCAGGTGTAAGCGC AGAAAGCAGGCGAACCCGCGGCGCAATAACGGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTC CTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCA GACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTG AACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAAGCAGCATCATGGAGGTAAGTTTTTGACCTTGAGAAA ATGTTTTTGTTTCACTGTCCTGAGGACTATTTATAGACAGCTCTAACATGATAACCCTCACTATGTGGAGAACATTGACAGAGTAACATT TTAGCAGGGAAAGAAGAATCCTACAGGGTCATGTTCCCTTCTCCTGTGGAGTGGCATGAAGAAGGTGTATGGCCCCAGGTATGGCCATAT TACTGACCCTCTACAGAGAGGGCAAAGGAACTGCCAGTATGGTATTGCAGGATAAAGGCAGGTGGTTACCCACATTACCTGCAAGGCTTT GATCTTTCTTCTGCCATTTCCACATTGGACATCTCTGCTGAGGAGAGAAAATGAACCACTCTTTTCCTTTGTATAATGTTGTTTTATTCT TCAGACAGAAGAGAGGAGTTATACAGCTCTGCAGACATCCCATTCCTGTATGGGGACTGTGTTTGCCTCTTAGAGGTTCCCAGGCCACTA GAGGAGATAAAGGGAAACAGATTGTTATAACTTGATATAATGATACTATAATAGATGTAACTACAAGGAGCTCCAGAAGCAAGAGAGAGG GAGGAACTTGGACTTCTCTGCATCTTTAGTTGGAGTCCAAAGGCTTTTCAATGAAATTCTACTGCCCAGGGTACATTGATGCTGAAACCC >In-frame_ENST00000361642_ENST00000559916_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(amino acids)=116AA_start in transcript=63_stop in transcript=413 MADGPRCKRRKQANPRRNNGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPT -------------------------------------------------------------- >In-frame_ENST00000560721_ENST00000558401_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(transcript)=1659nt_BP=81nt ATTTAGACACAAGCGAGAGGATCATGGCGGATGGCCCCAGGTGTAAGCGCAGAAAGCAGGCGAACCCGCGGCGCAATAACGGTACTCCAA AGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTG AAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGT ACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGG ATCGAGACATGTAAGCAGCATCATGGAGGTTTGAAGATGCCGCATTTGGATTGGATGAATTCCAAATTCTGCTTGCTTGCTTTTTAATAT TGATATGCTTATACACTTACACTTTATGCACAAAATGTAGGGTTATAATAATGTTAACATGGACATGATCTTCTTTATAATTCTACTTTG AGTGCTGTCTCCATGTTTGATGTATCTGAGCAGGTTGCTCCACAGGTAGCTCTAGGAGGGCTGGCAACTTAGAGGTGGGGAGCAGAGAAT TCTCTTATCCAACATCAACATCTTGGTCAGATTTGAACTCTTCAATCTCTTGCACTCAAAGCTTGTTAAGATAGTTAAGCGTGCATAAGT TAACTTCCAATTTACATACTCTGCTTAGAATTTGGGGGAAAATTTAGAAATATAATTGACAGGATTATTGGAAATTTGTTATAATGAATG AAACATTTTGTCATATAAGATTCATATTTACTTCTTATACATTTGATAAAGTAAGGCATGGTTGTGGTTAATCTGGTTTATTTTTGTTCC ACAAGTTAAATAAATCATAAAACTTGATGTGTTATCTCTTATATCTCACTCCCACTATTACCCCTTTATTTTCAAACAGGGAAACAGTCT TCAAGTTCCACTTGGTAAAAAATGTGAACCCCTTGTATATAGAGTTTGGCTCACAGTGTAAAGGGCCTCAGTGATTCACATTTTCCAGAT TAGGAATCTGATGCTCAAAGAAGTTAAATGGCATAGTTGGGGTGACACAGCTGTCTAGTGGGAGGCCAGCCTTCTATATTTTAGCCAGCG TTCTTTCCTGCGGGCCAGGTCATGAGGAGTATGCAGACTCTAAGAGGGAGCAAAAGTATCTGAAGGATTTAATATTTTAGCAAGGAATAG ATATACAATCATCCCTTGGTCTCCCTGGGGGATTGGTTTCAGGACCCCTTCTTGGACACCAAATCTATGGATATTTAAGTCCCTTCTATA AAATGGTATAGTATTTGCATATAACCTATCCACATCCTCCTGTATACTTTAAATCATTTCTAGATTACTTGTAATACCTAATACAATGTA AATGCTATGCAAATAGTTGTTATTGTTTAAGGAATAATGACAAGAAAAAAAAGTCTGTACATGCTCAGTAAAGACACAACCATCCCTTTT TTTCCCCAGTGTTTTTGATCCATGGTTTGCTGAATCCACAGATGTGGAGCCCCTGGATACGGAAGGCCCGCTGTACTTTGAATGACAAAT >In-frame_ENST00000560721_ENST00000558401_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(amino acids)=116AA_start in transcript=23_stop in transcript=373 MADGPRCKRRKQANPRRNNGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPT -------------------------------------------------------------- >In-frame_ENST00000560721_ENST00000559916_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(transcript)=1061nt_BP=81nt ATTTAGACACAAGCGAGAGGATCATGGCGGATGGCCCCAGGTGTAAGCGCAGAAAGCAGGCGAACCCGCGGCGCAATAACGGTACTCCAA AGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTG AAGTTGACTTACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGT ACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGG ATCGAGACATGTAAGCAGCATCATGGAGGTAAGTTTTTGACCTTGAGAAAATGTTTTTGTTTCACTGTCCTGAGGACTATTTATAGACAG CTCTAACATGATAACCCTCACTATGTGGAGAACATTGACAGAGTAACATTTTAGCAGGGAAAGAAGAATCCTACAGGGTCATGTTCCCTT CTCCTGTGGAGTGGCATGAAGAAGGTGTATGGCCCCAGGTATGGCCATATTACTGACCCTCTACAGAGAGGGCAAAGGAACTGCCAGTAT GGTATTGCAGGATAAAGGCAGGTGGTTACCCACATTACCTGCAAGGCTTTGATCTTTCTTCTGCCATTTCCACATTGGACATCTCTGCTG AGGAGAGAAAATGAACCACTCTTTTCCTTTGTATAATGTTGTTTTATTCTTCAGACAGAAGAGAGGAGTTATACAGCTCTGCAGACATCC CATTCCTGTATGGGGACTGTGTTTGCCTCTTAGAGGTTCCCAGGCCACTAGAGGAGATAAAGGGAAACAGATTGTTATAACTTGATATAA TGATACTATAATAGATGTAACTACAAGGAGCTCCAGAAGCAAGAGAGAGGGAGGAACTTGGACTTCTCTGCATCTTTAGTTGGAGTCCAA >In-frame_ENST00000560721_ENST00000559916_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(amino acids)=116AA_start in transcript=23_stop in transcript=373 MADGPRCKRRKQANPRRNNGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPT -------------------------------------------------------------- >In-frame_ENST00000542815_ENST00000558401_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(transcript)=1649nt_BP=71nt AAGCGAGAGGATCATGGCGGATGGCCCCAGGTGTAAGCGCAGAAAGCAGGCGAACCCGCGGCGCAATAACGGTACTCCAAAGATTCAGGT TTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTT ACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGA ATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACAT GTAAGCAGCATCATGGAGGTTTGAAGATGCCGCATTTGGATTGGATGAATTCCAAATTCTGCTTGCTTGCTTTTTAATATTGATATGCTT ATACACTTACACTTTATGCACAAAATGTAGGGTTATAATAATGTTAACATGGACATGATCTTCTTTATAATTCTACTTTGAGTGCTGTCT CCATGTTTGATGTATCTGAGCAGGTTGCTCCACAGGTAGCTCTAGGAGGGCTGGCAACTTAGAGGTGGGGAGCAGAGAATTCTCTTATCC AACATCAACATCTTGGTCAGATTTGAACTCTTCAATCTCTTGCACTCAAAGCTTGTTAAGATAGTTAAGCGTGCATAAGTTAACTTCCAA TTTACATACTCTGCTTAGAATTTGGGGGAAAATTTAGAAATATAATTGACAGGATTATTGGAAATTTGTTATAATGAATGAAACATTTTG TCATATAAGATTCATATTTACTTCTTATACATTTGATAAAGTAAGGCATGGTTGTGGTTAATCTGGTTTATTTTTGTTCCACAAGTTAAA TAAATCATAAAACTTGATGTGTTATCTCTTATATCTCACTCCCACTATTACCCCTTTATTTTCAAACAGGGAAACAGTCTTCAAGTTCCA CTTGGTAAAAAATGTGAACCCCTTGTATATAGAGTTTGGCTCACAGTGTAAAGGGCCTCAGTGATTCACATTTTCCAGATTAGGAATCTG ATGCTCAAAGAAGTTAAATGGCATAGTTGGGGTGACACAGCTGTCTAGTGGGAGGCCAGCCTTCTATATTTTAGCCAGCGTTCTTTCCTG CGGGCCAGGTCATGAGGAGTATGCAGACTCTAAGAGGGAGCAAAAGTATCTGAAGGATTTAATATTTTAGCAAGGAATAGATATACAATC ATCCCTTGGTCTCCCTGGGGGATTGGTTTCAGGACCCCTTCTTGGACACCAAATCTATGGATATTTAAGTCCCTTCTATAAAATGGTATA GTATTTGCATATAACCTATCCACATCCTCCTGTATACTTTAAATCATTTCTAGATTACTTGTAATACCTAATACAATGTAAATGCTATGC AAATAGTTGTTATTGTTTAAGGAATAATGACAAGAAAAAAAAGTCTGTACATGCTCAGTAAAGACACAACCATCCCTTTTTTTCCCCAGT GTTTTTGATCCATGGTTTGCTGAATCCACAGATGTGGAGCCCCTGGATACGGAAGGCCCGCTGTACTTTGAATGACAAATAACAGATTTA >In-frame_ENST00000542815_ENST00000558401_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(amino acids)=116AA_start in transcript=13_stop in transcript=363 MADGPRCKRRKQANPRRNNGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPT -------------------------------------------------------------- >In-frame_ENST00000542815_ENST00000559916_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(transcript)=1051nt_BP=71nt AAGCGAGAGGATCATGGCGGATGGCCCCAGGTGTAAGCGCAGAAAGCAGGCGAACCCGCGGCGCAATAACGGTACTCCAAAGATTCAGGT TTACTCACGTCATCCAGCAGAGAATGGAAAGTCAAATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTT ACTGAAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGGTCTTTCTATCTCTTGTACTACACTGA ATTCACCCCCACTGAAAAAGATGAGTATGCCTGCCGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACAT GTAAGCAGCATCATGGAGGTAAGTTTTTGACCTTGAGAAAATGTTTTTGTTTCACTGTCCTGAGGACTATTTATAGACAGCTCTAACATG ATAACCCTCACTATGTGGAGAACATTGACAGAGTAACATTTTAGCAGGGAAAGAAGAATCCTACAGGGTCATGTTCCCTTCTCCTGTGGA GTGGCATGAAGAAGGTGTATGGCCCCAGGTATGGCCATATTACTGACCCTCTACAGAGAGGGCAAAGGAACTGCCAGTATGGTATTGCAG GATAAAGGCAGGTGGTTACCCACATTACCTGCAAGGCTTTGATCTTTCTTCTGCCATTTCCACATTGGACATCTCTGCTGAGGAGAGAAA ATGAACCACTCTTTTCCTTTGTATAATGTTGTTTTATTCTTCAGACAGAAGAGAGGAGTTATACAGCTCTGCAGACATCCCATTCCTGTA TGGGGACTGTGTTTGCCTCTTAGAGGTTCCCAGGCCACTAGAGGAGATAAAGGGAAACAGATTGTTATAACTTGATATAATGATACTATA ATAGATGTAACTACAAGGAGCTCCAGAAGCAAGAGAGAGGGAGGAACTTGGACTTCTCTGCATCTTTAGTTGGAGTCCAAAGGCTTTTCA >In-frame_ENST00000542815_ENST00000559916_TCGA-EO-A3AV-01A_ZEB1_chr10_31608221_+_B2M_chr15_45007621_length(amino acids)=116AA_start in transcript=13_stop in transcript=363 MADGPRCKRRKQANPRRNNGTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPT -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for ZEB1-B2M |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for ZEB1-B2M |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | B2M | P61769 | DB09130 | Copper | Small molecule | Approved|Investigational | |
Tgene | B2M | P61769 | DB09130 | Copper | Small molecule | Approved|Investigational | |
Tgene | B2M | P61769 | DB09130 | Copper | Small molecule | Approved|Investigational |
Top |
Related Diseases for ZEB1-B2M |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZEB1 | C2750448 | CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 6 | 4 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | ZEB1 | C0006142 | Malignant neoplasm of breast | 2 | CTD_human |
Hgene | ZEB1 | C0339284 | Polymorphous corneal dystrophy | 2 | ORPHANET |
Hgene | ZEB1 | C0678222 | Breast Carcinoma | 2 | CTD_human |
Hgene | ZEB1 | C1257931 | Mammary Neoplasms, Human | 2 | CTD_human |
Hgene | ZEB1 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Hgene | ZEB1 | C1836724 | CORNEAL DYSTROPHY, POSTERIOR POLYMORPHOUS, 3 (disorder) | 2 | CTD_human;GENOMICS_ENGLAND |
Hgene | ZEB1 | C4704874 | Mammary Carcinoma, Human | 2 | CTD_human |
Hgene | ZEB1 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | ZEB1 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | ZEB1 | C0016781 | Fuchs Endothelial Dystrophy | 1 | GENOMICS_ENGLAND;ORPHANET |
Hgene | ZEB1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | ZEB1 | C0029172 | Oral Submucous Fibrosis | 1 | CTD_human |
Hgene | ZEB1 | C0036920 | Sezary Syndrome | 1 | CTD_human |
Hgene | ZEB1 | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
Hgene | ZEB1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Hgene | ZEB1 | C0235874 | Disease Exacerbation | 1 | CTD_human |
Hgene | ZEB1 | C0238463 | Papillary thyroid carcinoma | 1 | CTD_human |
Hgene | ZEB1 | C0376407 | Granulomatous Slack Skin | 1 | CTD_human |
Hgene | ZEB1 | C0476089 | Endometrial Carcinoma | 1 | CTD_human |
Hgene | ZEB1 | C0919267 | ovarian neoplasm | 1 | CTD_human |
Hgene | ZEB1 | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human |
Hgene | ZEB1 | C3501843 | Nonmedullary Thyroid Carcinoma | 1 | CTD_human |
Hgene | ZEB1 | C3501844 | Familial Nonmedullary Thyroid Cancer | 1 | CTD_human |
Tgene | B2M | C0022658 | Kidney Diseases | 3 | CTD_human |
Tgene | B2M | C0022660 | Kidney Failure, Acute | 3 | CTD_human |
Tgene | B2M | C1565662 | Acute Kidney Insufficiency | 3 | CTD_human |
Tgene | B2M | C2609414 | Acute kidney injury | 3 | CTD_human |
Tgene | B2M | C1855796 | Hypoproteinemia, Hypercatabolic | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | B2M | C0004364 | Autoimmune Diseases | 1 | CTD_human |
Tgene | B2M | C0013221 | Drug toxicity | 1 | CTD_human |
Tgene | B2M | C0018799 | Heart Diseases | 1 | CTD_human |
Tgene | B2M | C0020455 | Hypergammaglobulinemia | 1 | CTD_human |
Tgene | B2M | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | B2M | C0041755 | Adverse reaction to drug | 1 | CTD_human |
Tgene | B2M | C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
Tgene | B2M | C0079774 | Peripheral T-Cell Lymphoma | 1 | CTD_human |
Tgene | B2M | C0268389 | Amyloidosis, familial visceral | 1 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Tgene | B2M | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Tgene | B2M | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
Tgene | B2M | C1858266 | Bare Lymphocyte Syndrome, Type I | 1 | ORPHANET |
Tgene | B2M | C4302669 | Autosomal dominant beta2-microglobulinic amyloidosis | 1 | ORPHANET |