FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:BNC2-UHRF2 (FusionGDB2 ID:10039)

Fusion Gene Summary for BNC2-UHRF2

check button Fusion gene summary
Fusion gene informationFusion gene name: BNC2-UHRF2
Fusion gene ID: 10039
HgeneTgene
Gene symbol

BNC2

UHRF2

Gene ID

54796

115426

Gene namebasonuclin 2ubiquitin like with PHD and ring finger domains 2
SynonymsBSN2|LUTONIRF|RNF107|TDRD23|URF2
Cytomap

9p22.3-p22.2

9p24.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein basonuclin-2E3 ubiquitin-protein ligase UHRF2Np95-like ring finger proteinRING finger protein 107RING-type E3 ubiquitin transferase UHRF2np95/ICBP90-like RING finger proteinnuclear protein 97nuclear zinc finger protein NP97ubiquitin-like PHD and RING finger do
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000380672, ENST00000380667, 
ENST00000545497, ENST00000380666, 
ENST00000471301, 		ENST00000276893, 
ENST00000381373, ENST00000485617, 
Fusion gene scores* DoF score12 X 16 X 6=115214 X 11 X 8=1232
# samples 1616
** MAII scorelog2(16/1152*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1232*10)=-2.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BNC2 [Title/Abstract] AND UHRF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBNC2(16870644)-UHRF2(6420912), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUHRF2

GO:0016567

protein ubiquitination

14741369

TgeneUHRF2

GO:0051865

protein autoubiquitination

14741369

TgeneUHRF2

GO:0071158

positive regulation of cell cycle arrest

15178429


check buttonFusion gene breakpoints across BNC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across UHRF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB2E-01ABNC2chr9

16870644

-UHRF2chr9

6420912

+


Top

Fusion Gene ORF analysis for BNC2-UHRF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000380672ENST00000276893BNC2chr9

16870644

-UHRF2chr9

6420912

+
In-frameENST00000380672ENST00000381373BNC2chr9

16870644

-UHRF2chr9

6420912

+
5CDS-intronENST00000380672ENST00000485617BNC2chr9

16870644

-UHRF2chr9

6420912

+
In-frameENST00000380667ENST00000276893BNC2chr9

16870644

-UHRF2chr9

6420912

+
In-frameENST00000380667ENST00000381373BNC2chr9

16870644

-UHRF2chr9

6420912

+
5CDS-intronENST00000380667ENST00000485617BNC2chr9

16870644

-UHRF2chr9

6420912

+
intron-3CDSENST00000545497ENST00000276893BNC2chr9

16870644

-UHRF2chr9

6420912

+
intron-3CDSENST00000545497ENST00000381373BNC2chr9

16870644

-UHRF2chr9

6420912

+
intron-intronENST00000545497ENST00000485617BNC2chr9

16870644

-UHRF2chr9

6420912

+
In-frameENST00000380666ENST00000276893BNC2chr9

16870644

-UHRF2chr9

6420912

+
In-frameENST00000380666ENST00000381373BNC2chr9

16870644

-UHRF2chr9

6420912

+
5CDS-intronENST00000380666ENST00000485617BNC2chr9

16870644

-UHRF2chr9

6420912

+
intron-3CDSENST00000471301ENST00000276893BNC2chr9

16870644

-UHRF2chr9

6420912

+
intron-3CDSENST00000471301ENST00000381373BNC2chr9

16870644

-UHRF2chr9

6420912

+
intron-intronENST00000471301ENST00000485617BNC2chr9

16870644

-UHRF2chr9

6420912

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380672BNC2chr916870644-ENST00000276893UHRF2chr96420912+319261582316752
ENST00000380672BNC2chr916870644-ENST00000381373UHRF2chr96420912+637615831886
ENST00000380667BNC2chr916870644-ENST00000276893UHRF2chr96420912+321786142341775
ENST00000380667BNC2chr916870644-ENST00000381373UHRF2chr96420912+6628614343109
ENST00000380666BNC2chr916870644-ENST00000276893UHRF2chr96420912+3274143712398775
ENST00000380666BNC2chr916870644-ENST00000381373UHRF2chr96420912+71914371400109

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380672ENST00000276893BNC2chr916870644-UHRF2chr96420912+0.000107580.99989235
ENST00000380672ENST00000381373BNC2chr916870644-UHRF2chr96420912+0.299255670.7007444
ENST00000380667ENST00000276893BNC2chr916870644-UHRF2chr96420912+0.0001095780.99989045
ENST00000380667ENST00000381373BNC2chr916870644-UHRF2chr96420912+0.289800550.7101994
ENST00000380666ENST00000276893BNC2chr916870644-UHRF2chr96420912+0.0001125170.99988747
ENST00000380666ENST00000381373BNC2chr916870644-UHRF2chr96420912+0.182272170.81772786

Top

Fusion Genomic Features for BNC2-UHRF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BNC2chr916870643-UHRF2chr96420911+8.55E-050.9999145
BNC2chr916870643-UHRF2chr96420911+8.55E-050.9999145

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for BNC2-UHRF2


check button Go to

FGviewer for the breakpoints of chr9:16870644-chr9:6420912

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneUHRF2chr9:16870644chr9:6420912ENST00000276893016448_61251.0803.0DomainYDG
TgeneUHRF2chr9:16870644chr9:6420912ENST00000276893016344_39551.0803.0Zinc fingerPHD-type
TgeneUHRF2chr9:16870644chr9:6420912ENST00000276893016733_77251.0803.0Zinc fingerRING-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBNC2chr9:16870644chr9:6420912ENST00000380666-17534_6141.0904.0Compositional biasPro-rich
HgeneBNC2chr9:16870644chr9:6420912ENST00000380672-17534_6141.01100.0Compositional biasPro-rich
HgeneBNC2chr9:16870644chr9:6420912ENST00000380666-171035_10581.0904.0Zinc fingerC2H2-type 3
HgeneBNC2chr9:16870644chr9:6420912ENST00000380666-171063_10901.0904.0Zinc fingerC2H2-type 4
HgeneBNC2chr9:16870644chr9:6420912ENST00000380666-17441_4641.0904.0Zinc fingerC2H2-type 1
HgeneBNC2chr9:16870644chr9:6420912ENST00000380666-17833_8561.0904.0Zinc fingerC2H2-type 2
HgeneBNC2chr9:16870644chr9:6420912ENST00000380672-171035_10581.01100.0Zinc fingerC2H2-type 3
HgeneBNC2chr9:16870644chr9:6420912ENST00000380672-171063_10901.01100.0Zinc fingerC2H2-type 4
HgeneBNC2chr9:16870644chr9:6420912ENST00000380672-17441_4641.01100.0Zinc fingerC2H2-type 1
HgeneBNC2chr9:16870644chr9:6420912ENST00000380672-17833_8561.01100.0Zinc fingerC2H2-type 2
TgeneUHRF2chr9:16870644chr9:6420912ENST000002768930161_7851.0803.0DomainUbiquitin-like


Top

Fusion Gene Sequence for BNC2-UHRF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000380672_ENST00000276893_TCGA-DX-AB2E-01A_BNC2_chr9_16870644_-_UHRF2_chr9_6420912_length(transcript)=3192nt_BP=61nt
GCGGCCGCTAAGAGGAGACCAAGAGGCGGGGGCTGCACTTGACAACCAGCATGCCGAGATGTTGGAAAATGGATATACCTTATTTGATTA
TGATGTTGGACTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACC
CTGTTCTAATAGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGA
TCCTGGCTTTGGAATATATAAGGTAAATGAATTGGTGGATGCCAGAGATGTCGGCCTTGGTGCTTGGTTTGAAGCACACATACATAGTGT
TACTAGAGCTTCTGATGGACAGTCACGTGGCAAAACTCCACTGAAGAATGGCAGTTCTTGTAAAAGGACTAATGGAAATATAAAGCATAA
ATCCAAAGAGAACACAAATAAATTGGACAGTGTACCCTCTACGTCTAATTCAGACTGTGTTGCTGCTGATGAAGACGTTATTTACCATAT
CCAGTATGATGAATACCCAGAAAGCGGTACTCTAGAAATGAATGTCAAGGATCTTAGACCACGAGCTAGAACCATTTTGAAATGGAATGA
ACTAAATGTTGGTGATGTGGTAATGGTTAATTATAATGTAGAAAGTCCTGGACAAAGAGGATTCTGGTTTGATGCAGAAATTACCACATT
GAAGACAATCTCAAGGACCAAAAAAGAACTTCGTGTGAAAATTTTCCTGGGGGGTTCTGAAGGAACATTAAATGACTGCAAGATAATATC
TGTAGATGAAATCTTCAAGATTGAGAGACCTGGAGCCCATCCCCTTTCATTTGCAGATGGAAAGTTTTTAAGGCGAAATGACCCTGAATG
TGACCTGTGTGGTGGAGACCCAGAAAAGAAATGTCATTCTTGCTCCTGTCGTGTATGTGGTGGGAAACATGAACCCAACATGCAGCTTCT
GTGTGATGAATGTAATGTGGCTTATCATATTTACTGTCTGAATCCACCTTTGGATAAAGTCCCAGAAGAGGAATACTGGTATTGTCCTTC
TTGTAAAACTGATTCCAGTGAAGTTGTAAAGGCTGGTGAAAGACTCAAGATGAGTAAAAAGAAAGCAAAGATGCCGTCAGCTAGTACTGA
AAGCCGAAGAGACTGGGGCAGGGGAATGGCTTGTGTTGGTCGTACGAGAGAATGTACTATTGTCCCTTCTAATCATTATGGACCCATTCC
TGGTATTCCTGTTGGATCAACTTGGAGATTTAGAGTTCAGGTGAGCGAAGCAGGTGTTCACAGACCCCATGTTGGTGGAATTCATGGTCG
AAGTAATGATGGGGCTTATTCTCTTGTACTGGCTGGTGGATTTGCGGATGAAGTCGACCGAGGTGATGAGTTCACATACACTGGAAGCGG
TGGTAAAAATCTTGCTGGTAACAAAAGAATTGGTGCACCTTCAGCTGATCAAACATTAACAAACATGAACAGGGCATTGGCCCTAAACTG
TGATGCTCCATTGGATGATAAAATTGGAGCAGAGTCTCGGAATTGGAGAGCTGGTAAGCCAGTCAGAGTGATACGCAGTTTTAAAGGGAG
GAAGATCAGCAAATATGCTCCTGAAGAAGGCAACAGATATGATGGCATTTATAAGGTGGTGAAATACTGGCCAGAGATTTCATCAAGCCA
TGGATTCTTGGTTTGGCGCTATCTTTTAAGAAGAGATGATGTTGAACCTGCTCCTTGGACCTCTGAAGGAATAGAACGGTCAAGGAGATT
ATGTCTACGTTTACAGTATCCAGCAGGTTACCCTTCAGATAAAGAAGGGAAGAAGCCTAAAGGACAGTCAAAGAAGCAGCCCAGTGGAAC
CACAAAAAGGCCAATTTCAGATGATGACTGTCCAAGTGCCTCCAAAGTGTACAAAGCATCAGATTCAGCAGAAGCAATTGAGGCTTTTCA
ACTAACTCCTCAACAGCAACATCTCATCAGAGAAGATTGTCAAAACCAGAAGCTGTGGGATGAAGTGCTTTCACATCTTGTGGAAGGACC
AAATTTTCTGAAAAAATTGGAACAATCTTTTATGTGCGTTTGCTGTCAGGAGCTAGTTTACCAGCCTGTGACAACTGAGTGCTTCCACAA
TGTCTGTAAAGATTGCCTACAGCGCTCCTTTAAGGCACAGGTTTTCTCCTGCCCTGCTTGCCGGCATGATCTTGGCCAGAATTACATCAT
GATTCCCAATGAGATTCTGCAGACTCTACTTGACCTTTTCTTCCCTGGCTACAGCAAAGGACGATGATCTGCCTGCTTTCACTGTGTTGT
TCATGGTGGCTTTTTGGACAATAAAGAATCTAAAATGGGTGGGGAGGGTGGAAGAAATGGTGGACTGTATCTCTCACGTTCTGAAGCAGC
TAATCCTCTTTCCCACATAGCCATCATCTTGTGTGTGTAGTAAGAGGCCCATTTCTCAACTGTCTTTTAAATATCTAAAGGTAGTTCCTG
TAACAACTAGTTTTAATGAGTAAAAAGTCAAAGCCTCAGCTCTAGTTGATATCCAAGTTATGATTTATTTTGCAACTACCTCAGGACAGA
AAAGATTTATGGGGATTTTAAAAATCATTGAATAACTAGTTAAATGAAATTTTAGCTACACACTGCCTCCCAAATATTAGTTGTGCCTGG
TTCTTGTAATTTGATTTTACAGAAAAGGAAATGACACTTGAGATCCTTGGAATGAACACAGCTTCTAAAGTGTGCATATACTTTTTTAAC
GTCTCTTCTTCCATTACAATGTGTGTTTTGCAAGGACAGGTTCATTTTTTTTAGCCCACTTTGTGAACTCCATTGTGCTTTTTTCTGGTG
TTTTATGCAAGTTGACTACTAATGACTAATGAGAACAATAATGAATGCATTGTTGCTGCATTAGTGTAATGTGGTGTGGTTTTGCACTTA
AAAGAGGTATTCATATGCTCTAGTTGTAAATGTTCATGAAAATCCACTTCTCTACTAGTCGAACTGCTTTTAGTGTCTCACCAGTGGTTT
TACATCTGCAGAGTTTTGAGGGCTGTGCTGACCTTTGAGAGGATTTGAAATTGCTTCATATTGTGATCCTAAATTTTATATTCACTATAT

>In-frame_ENST00000380672_ENST00000276893_TCGA-DX-AB2E-01A_BNC2_chr9_16870644_-_UHRF2_chr9_6420912_length(amino acids)=752AA_start in transcript=58_stop in transcript=2316
MLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARARLIDPGFGIYKVNELVDARDVGL
GAWFEAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDVIYHIQYDEYPESGTLEMNVKDLR
PRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDCKIISVDEIFKIERPGAHPLSFAD
GKFLRRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYWYCPSCKTDSSEVVKAGERLKMSK
KKAKMPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGGIHGRSNDGAYSLVLAGGFADEVD
RGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRSFKGRKISKYAPEEGNRYDGIYKV
VKYWPEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQPSGTTKRPISDDDCPSASKVYKA
SDSAEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLVEGPNFLKKLEQSFMCVCCQELVYQPVTTECFHNVCKDCLQRSFKAQVFSCPA

--------------------------------------------------------------
>In-frame_ENST00000380672_ENST00000381373_TCGA-DX-AB2E-01A_BNC2_chr9_16870644_-_UHRF2_chr9_6420912_length(transcript)=637nt_BP=61nt
GCGGCCGCTAAGAGGAGACCAAGAGGCGGGGGCTGCACTTGACAACCAGCATGCCGAGATGTTGGAAAATGGATATACCTTATTTGATTA
TGATGTTGGACTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACC
CTGTTCTAATAGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGA
TCCTGGCTTTGGAATATATAAGGGTCTGGCTCTGTCACCCAGGCTGTAGTGCAGTGACGTGAACACGGCTCGCTGTAGCCTTGACCTGCT
GGGGTCAAGTGATCTTCCTGCTCGGCCTCCCAAAGTGCTGGGATACAGGCGTGAGCCACCATGCCCGGCTAACTTAGATCTTTGATATCT
TGATTAGTTCTTTCTTTACATATTTAATATTTTGCTTTATTTCTGGTAGCTTTGTTTTTGATGCAATTATTATATATGGTTATCTTCTAA
AATAGTAATCTGTTTGCTGATATAGAGAAATGAAATTGATTTATTTGGCTTTTGTAACCAGCAACCTTTTCAAATCTAATAAATTGTGTA

>In-frame_ENST00000380672_ENST00000381373_TCGA-DX-AB2E-01A_BNC2_chr9_16870644_-_UHRF2_chr9_6420912_length(amino acids)=86AA_start in transcript=58_stop in transcript=318

--------------------------------------------------------------
>In-frame_ENST00000380667_ENST00000276893_TCGA-DX-AB2E-01A_BNC2_chr9_16870644_-_UHRF2_chr9_6420912_length(transcript)=3217nt_BP=86nt
CGGCGGCCGAGGGGCTGGTCCAGGCGCGGCCGCTAAGAGGAGACCAAGAGGCGGGGGCTGCACTTGACAACCAGCATGCCGAGATGTTGG
AAAATGGATATACCTTATTTGATTATGATGTTGGACTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCA
CATCTACACAGATTGAGGCTAAACCCTGTTCTAATAGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTA
CATCAGCTCGTGCCCGTCTTATTGATCCTGGCTTTGGAATATATAAGGTAAATGAATTGGTGGATGCCAGAGATGTCGGCCTTGGTGCTT
GGTTTGAAGCACACATACATAGTGTTACTAGAGCTTCTGATGGACAGTCACGTGGCAAAACTCCACTGAAGAATGGCAGTTCTTGTAAAA
GGACTAATGGAAATATAAAGCATAAATCCAAAGAGAACACAAATAAATTGGACAGTGTACCCTCTACGTCTAATTCAGACTGTGTTGCTG
CTGATGAAGACGTTATTTACCATATCCAGTATGATGAATACCCAGAAAGCGGTACTCTAGAAATGAATGTCAAGGATCTTAGACCACGAG
CTAGAACCATTTTGAAATGGAATGAACTAAATGTTGGTGATGTGGTAATGGTTAATTATAATGTAGAAAGTCCTGGACAAAGAGGATTCT
GGTTTGATGCAGAAATTACCACATTGAAGACAATCTCAAGGACCAAAAAAGAACTTCGTGTGAAAATTTTCCTGGGGGGTTCTGAAGGAA
CATTAAATGACTGCAAGATAATATCTGTAGATGAAATCTTCAAGATTGAGAGACCTGGAGCCCATCCCCTTTCATTTGCAGATGGAAAGT
TTTTAAGGCGAAATGACCCTGAATGTGACCTGTGTGGTGGAGACCCAGAAAAGAAATGTCATTCTTGCTCCTGTCGTGTATGTGGTGGGA
AACATGAACCCAACATGCAGCTTCTGTGTGATGAATGTAATGTGGCTTATCATATTTACTGTCTGAATCCACCTTTGGATAAAGTCCCAG
AAGAGGAATACTGGTATTGTCCTTCTTGTAAAACTGATTCCAGTGAAGTTGTAAAGGCTGGTGAAAGACTCAAGATGAGTAAAAAGAAAG
CAAAGATGCCGTCAGCTAGTACTGAAAGCCGAAGAGACTGGGGCAGGGGAATGGCTTGTGTTGGTCGTACGAGAGAATGTACTATTGTCC
CTTCTAATCATTATGGACCCATTCCTGGTATTCCTGTTGGATCAACTTGGAGATTTAGAGTTCAGGTGAGCGAAGCAGGTGTTCACAGAC
CCCATGTTGGTGGAATTCATGGTCGAAGTAATGATGGGGCTTATTCTCTTGTACTGGCTGGTGGATTTGCGGATGAAGTCGACCGAGGTG
ATGAGTTCACATACACTGGAAGCGGTGGTAAAAATCTTGCTGGTAACAAAAGAATTGGTGCACCTTCAGCTGATCAAACATTAACAAACA
TGAACAGGGCATTGGCCCTAAACTGTGATGCTCCATTGGATGATAAAATTGGAGCAGAGTCTCGGAATTGGAGAGCTGGTAAGCCAGTCA
GAGTGATACGCAGTTTTAAAGGGAGGAAGATCAGCAAATATGCTCCTGAAGAAGGCAACAGATATGATGGCATTTATAAGGTGGTGAAAT
ACTGGCCAGAGATTTCATCAAGCCATGGATTCTTGGTTTGGCGCTATCTTTTAAGAAGAGATGATGTTGAACCTGCTCCTTGGACCTCTG
AAGGAATAGAACGGTCAAGGAGATTATGTCTACGTTTACAGTATCCAGCAGGTTACCCTTCAGATAAAGAAGGGAAGAAGCCTAAAGGAC
AGTCAAAGAAGCAGCCCAGTGGAACCACAAAAAGGCCAATTTCAGATGATGACTGTCCAAGTGCCTCCAAAGTGTACAAAGCATCAGATT
CAGCAGAAGCAATTGAGGCTTTTCAACTAACTCCTCAACAGCAACATCTCATCAGAGAAGATTGTCAAAACCAGAAGCTGTGGGATGAAG
TGCTTTCACATCTTGTGGAAGGACCAAATTTTCTGAAAAAATTGGAACAATCTTTTATGTGCGTTTGCTGTCAGGAGCTAGTTTACCAGC
CTGTGACAACTGAGTGCTTCCACAATGTCTGTAAAGATTGCCTACAGCGCTCCTTTAAGGCACAGGTTTTCTCCTGCCCTGCTTGCCGGC
ATGATCTTGGCCAGAATTACATCATGATTCCCAATGAGATTCTGCAGACTCTACTTGACCTTTTCTTCCCTGGCTACAGCAAAGGACGAT
GATCTGCCTGCTTTCACTGTGTTGTTCATGGTGGCTTTTTGGACAATAAAGAATCTAAAATGGGTGGGGAGGGTGGAAGAAATGGTGGAC
TGTATCTCTCACGTTCTGAAGCAGCTAATCCTCTTTCCCACATAGCCATCATCTTGTGTGTGTAGTAAGAGGCCCATTTCTCAACTGTCT
TTTAAATATCTAAAGGTAGTTCCTGTAACAACTAGTTTTAATGAGTAAAAAGTCAAAGCCTCAGCTCTAGTTGATATCCAAGTTATGATT
TATTTTGCAACTACCTCAGGACAGAAAAGATTTATGGGGATTTTAAAAATCATTGAATAACTAGTTAAATGAAATTTTAGCTACACACTG
CCTCCCAAATATTAGTTGTGCCTGGTTCTTGTAATTTGATTTTACAGAAAAGGAAATGACACTTGAGATCCTTGGAATGAACACAGCTTC
TAAAGTGTGCATATACTTTTTTAACGTCTCTTCTTCCATTACAATGTGTGTTTTGCAAGGACAGGTTCATTTTTTTTAGCCCACTTTGTG
AACTCCATTGTGCTTTTTTCTGGTGTTTTATGCAAGTTGACTACTAATGACTAATGAGAACAATAATGAATGCATTGTTGCTGCATTAGT
GTAATGTGGTGTGGTTTTGCACTTAAAAGAGGTATTCATATGCTCTAGTTGTAAATGTTCATGAAAATCCACTTCTCTACTAGTCGAACT
GCTTTTAGTGTCTCACCAGTGGTTTTACATCTGCAGAGTTTTGAGGGCTGTGCTGACCTTTGAGAGGATTTGAAATTGCTTCATATTGTG

>In-frame_ENST00000380667_ENST00000276893_TCGA-DX-AB2E-01A_BNC2_chr9_16870644_-_UHRF2_chr9_6420912_length(amino acids)=775AA_start in transcript=14_stop in transcript=2341
MVQARPLRGDQEAGAALDNQHAEMLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARA
RLIDPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDV
IYHIQYDEYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDC
KIISVDEIFKIERPGAHPLSFADGKFLRRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYW
YCPSCKTDSSEVVKAGERLKMSKKKAKMPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGG
IHGRSNDGAYSLVLAGGFADEVDRGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRS
FKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQ
PSGTTKRPISDDDCPSASKVYKASDSAEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLVEGPNFLKKLEQSFMCVCCQELVYQPVTTE

--------------------------------------------------------------
>In-frame_ENST00000380667_ENST00000381373_TCGA-DX-AB2E-01A_BNC2_chr9_16870644_-_UHRF2_chr9_6420912_length(transcript)=662nt_BP=86nt
CGGCGGCCGAGGGGCTGGTCCAGGCGCGGCCGCTAAGAGGAGACCAAGAGGCGGGGGCTGCACTTGACAACCAGCATGCCGAGATGTTGG
AAAATGGATATACCTTATTTGATTATGATGTTGGACTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCA
CATCTACACAGATTGAGGCTAAACCCTGTTCTAATAGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTA
CATCAGCTCGTGCCCGTCTTATTGATCCTGGCTTTGGAATATATAAGGGTCTGGCTCTGTCACCCAGGCTGTAGTGCAGTGACGTGAACA
CGGCTCGCTGTAGCCTTGACCTGCTGGGGTCAAGTGATCTTCCTGCTCGGCCTCCCAAAGTGCTGGGATACAGGCGTGAGCCACCATGCC
CGGCTAACTTAGATCTTTGATATCTTGATTAGTTCTTTCTTTACATATTTAATATTTTGCTTTATTTCTGGTAGCTTTGTTTTTGATGCA
ATTATTATATATGGTTATCTTCTAAAATAGTAATCTGTTTGCTGATATAGAGAAATGAAATTGATTTATTTGGCTTTTGTAACCAGCAAC

>In-frame_ENST00000380667_ENST00000381373_TCGA-DX-AB2E-01A_BNC2_chr9_16870644_-_UHRF2_chr9_6420912_length(amino acids)=109AA_start in transcript=14_stop in transcript=343
MVQARPLRGDQEAGAALDNQHAEMLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARA

--------------------------------------------------------------
>In-frame_ENST00000380666_ENST00000276893_TCGA-DX-AB2E-01A_BNC2_chr9_16870644_-_UHRF2_chr9_6420912_length(transcript)=3274nt_BP=143nt
GAGGCCCGGAGGAACTCGGAGGGGGAGGGAGAGAAAGGCCGAGACGGAGGGAGCCAGCGGCGGCCGAGGGGCTGGTCCAGGCGCGGCCGC
TAAGAGGAGACCAAGAGGCGGGGGCTGCACTTGACAACCAGCATGCCGAGATGTTGGAAAATGGATATACCTTATTTGATTATGATGTTG
GACTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACCCTGTTCTA
ATAGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGATCCTGGCT
TTGGAATATATAAGGTAAATGAATTGGTGGATGCCAGAGATGTCGGCCTTGGTGCTTGGTTTGAAGCACACATACATAGTGTTACTAGAG
CTTCTGATGGACAGTCACGTGGCAAAACTCCACTGAAGAATGGCAGTTCTTGTAAAAGGACTAATGGAAATATAAAGCATAAATCCAAAG
AGAACACAAATAAATTGGACAGTGTACCCTCTACGTCTAATTCAGACTGTGTTGCTGCTGATGAAGACGTTATTTACCATATCCAGTATG
ATGAATACCCAGAAAGCGGTACTCTAGAAATGAATGTCAAGGATCTTAGACCACGAGCTAGAACCATTTTGAAATGGAATGAACTAAATG
TTGGTGATGTGGTAATGGTTAATTATAATGTAGAAAGTCCTGGACAAAGAGGATTCTGGTTTGATGCAGAAATTACCACATTGAAGACAA
TCTCAAGGACCAAAAAAGAACTTCGTGTGAAAATTTTCCTGGGGGGTTCTGAAGGAACATTAAATGACTGCAAGATAATATCTGTAGATG
AAATCTTCAAGATTGAGAGACCTGGAGCCCATCCCCTTTCATTTGCAGATGGAAAGTTTTTAAGGCGAAATGACCCTGAATGTGACCTGT
GTGGTGGAGACCCAGAAAAGAAATGTCATTCTTGCTCCTGTCGTGTATGTGGTGGGAAACATGAACCCAACATGCAGCTTCTGTGTGATG
AATGTAATGTGGCTTATCATATTTACTGTCTGAATCCACCTTTGGATAAAGTCCCAGAAGAGGAATACTGGTATTGTCCTTCTTGTAAAA
CTGATTCCAGTGAAGTTGTAAAGGCTGGTGAAAGACTCAAGATGAGTAAAAAGAAAGCAAAGATGCCGTCAGCTAGTACTGAAAGCCGAA
GAGACTGGGGCAGGGGAATGGCTTGTGTTGGTCGTACGAGAGAATGTACTATTGTCCCTTCTAATCATTATGGACCCATTCCTGGTATTC
CTGTTGGATCAACTTGGAGATTTAGAGTTCAGGTGAGCGAAGCAGGTGTTCACAGACCCCATGTTGGTGGAATTCATGGTCGAAGTAATG
ATGGGGCTTATTCTCTTGTACTGGCTGGTGGATTTGCGGATGAAGTCGACCGAGGTGATGAGTTCACATACACTGGAAGCGGTGGTAAAA
ATCTTGCTGGTAACAAAAGAATTGGTGCACCTTCAGCTGATCAAACATTAACAAACATGAACAGGGCATTGGCCCTAAACTGTGATGCTC
CATTGGATGATAAAATTGGAGCAGAGTCTCGGAATTGGAGAGCTGGTAAGCCAGTCAGAGTGATACGCAGTTTTAAAGGGAGGAAGATCA
GCAAATATGCTCCTGAAGAAGGCAACAGATATGATGGCATTTATAAGGTGGTGAAATACTGGCCAGAGATTTCATCAAGCCATGGATTCT
TGGTTTGGCGCTATCTTTTAAGAAGAGATGATGTTGAACCTGCTCCTTGGACCTCTGAAGGAATAGAACGGTCAAGGAGATTATGTCTAC
GTTTACAGTATCCAGCAGGTTACCCTTCAGATAAAGAAGGGAAGAAGCCTAAAGGACAGTCAAAGAAGCAGCCCAGTGGAACCACAAAAA
GGCCAATTTCAGATGATGACTGTCCAAGTGCCTCCAAAGTGTACAAAGCATCAGATTCAGCAGAAGCAATTGAGGCTTTTCAACTAACTC
CTCAACAGCAACATCTCATCAGAGAAGATTGTCAAAACCAGAAGCTGTGGGATGAAGTGCTTTCACATCTTGTGGAAGGACCAAATTTTC
TGAAAAAATTGGAACAATCTTTTATGTGCGTTTGCTGTCAGGAGCTAGTTTACCAGCCTGTGACAACTGAGTGCTTCCACAATGTCTGTA
AAGATTGCCTACAGCGCTCCTTTAAGGCACAGGTTTTCTCCTGCCCTGCTTGCCGGCATGATCTTGGCCAGAATTACATCATGATTCCCA
ATGAGATTCTGCAGACTCTACTTGACCTTTTCTTCCCTGGCTACAGCAAAGGACGATGATCTGCCTGCTTTCACTGTGTTGTTCATGGTG
GCTTTTTGGACAATAAAGAATCTAAAATGGGTGGGGAGGGTGGAAGAAATGGTGGACTGTATCTCTCACGTTCTGAAGCAGCTAATCCTC
TTTCCCACATAGCCATCATCTTGTGTGTGTAGTAAGAGGCCCATTTCTCAACTGTCTTTTAAATATCTAAAGGTAGTTCCTGTAACAACT
AGTTTTAATGAGTAAAAAGTCAAAGCCTCAGCTCTAGTTGATATCCAAGTTATGATTTATTTTGCAACTACCTCAGGACAGAAAAGATTT
ATGGGGATTTTAAAAATCATTGAATAACTAGTTAAATGAAATTTTAGCTACACACTGCCTCCCAAATATTAGTTGTGCCTGGTTCTTGTA
ATTTGATTTTACAGAAAAGGAAATGACACTTGAGATCCTTGGAATGAACACAGCTTCTAAAGTGTGCATATACTTTTTTAACGTCTCTTC
TTCCATTACAATGTGTGTTTTGCAAGGACAGGTTCATTTTTTTTAGCCCACTTTGTGAACTCCATTGTGCTTTTTTCTGGTGTTTTATGC
AAGTTGACTACTAATGACTAATGAGAACAATAATGAATGCATTGTTGCTGCATTAGTGTAATGTGGTGTGGTTTTGCACTTAAAAGAGGT
ATTCATATGCTCTAGTTGTAAATGTTCATGAAAATCCACTTCTCTACTAGTCGAACTGCTTTTAGTGTCTCACCAGTGGTTTTACATCTG
CAGAGTTTTGAGGGCTGTGCTGACCTTTGAGAGGATTTGAAATTGCTTCATATTGTGATCCTAAATTTTATATTCACTATATTCCCTAAA

>In-frame_ENST00000380666_ENST00000276893_TCGA-DX-AB2E-01A_BNC2_chr9_16870644_-_UHRF2_chr9_6420912_length(amino acids)=775AA_start in transcript=71_stop in transcript=2398
MVQARPLRGDQEAGAALDNQHAEMLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARA
RLIDPGFGIYKVNELVDARDVGLGAWFEAHIHSVTRASDGQSRGKTPLKNGSSCKRTNGNIKHKSKENTNKLDSVPSTSNSDCVAADEDV
IYHIQYDEYPESGTLEMNVKDLRPRARTILKWNELNVGDVVMVNYNVESPGQRGFWFDAEITTLKTISRTKKELRVKIFLGGSEGTLNDC
KIISVDEIFKIERPGAHPLSFADGKFLRRNDPECDLCGGDPEKKCHSCSCRVCGGKHEPNMQLLCDECNVAYHIYCLNPPLDKVPEEEYW
YCPSCKTDSSEVVKAGERLKMSKKKAKMPSASTESRRDWGRGMACVGRTRECTIVPSNHYGPIPGIPVGSTWRFRVQVSEAGVHRPHVGG
IHGRSNDGAYSLVLAGGFADEVDRGDEFTYTGSGGKNLAGNKRIGAPSADQTLTNMNRALALNCDAPLDDKIGAESRNWRAGKPVRVIRS
FKGRKISKYAPEEGNRYDGIYKVVKYWPEISSSHGFLVWRYLLRRDDVEPAPWTSEGIERSRRLCLRLQYPAGYPSDKEGKKPKGQSKKQ
PSGTTKRPISDDDCPSASKVYKASDSAEAIEAFQLTPQQQHLIREDCQNQKLWDEVLSHLVEGPNFLKKLEQSFMCVCCQELVYQPVTTE

--------------------------------------------------------------
>In-frame_ENST00000380666_ENST00000381373_TCGA-DX-AB2E-01A_BNC2_chr9_16870644_-_UHRF2_chr9_6420912_length(transcript)=719nt_BP=143nt
GAGGCCCGGAGGAACTCGGAGGGGGAGGGAGAGAAAGGCCGAGACGGAGGGAGCCAGCGGCGGCCGAGGGGCTGGTCCAGGCGCGGCCGC
TAAGAGGAGACCAAGAGGCGGGGGCTGCACTTGACAACCAGCATGCCGAGATGTTGGAAAATGGATATACCTTATTTGATTATGATGTTG
GACTGAATGATATAATTCAGCTGCTAGTTCGCCCAGACCCTGATCATCTTCCTGGCACATCTACACAGATTGAGGCTAAACCCTGTTCTA
ATAGTCCACCTAAAGTAAAGAAAGCTCCGAGGGTAGGACCTTCCAATCAGCCATCTACATCAGCTCGTGCCCGTCTTATTGATCCTGGCT
TTGGAATATATAAGGGTCTGGCTCTGTCACCCAGGCTGTAGTGCAGTGACGTGAACACGGCTCGCTGTAGCCTTGACCTGCTGGGGTCAA
GTGATCTTCCTGCTCGGCCTCCCAAAGTGCTGGGATACAGGCGTGAGCCACCATGCCCGGCTAACTTAGATCTTTGATATCTTGATTAGT
TCTTTCTTTACATATTTAATATTTTGCTTTATTTCTGGTAGCTTTGTTTTTGATGCAATTATTATATATGGTTATCTTCTAAAATAGTAA

>In-frame_ENST00000380666_ENST00000381373_TCGA-DX-AB2E-01A_BNC2_chr9_16870644_-_UHRF2_chr9_6420912_length(amino acids)=109AA_start in transcript=71_stop in transcript=400
MVQARPLRGDQEAGAALDNQHAEMLENGYTLFDYDVGLNDIIQLLVRPDPDHLPGTSTQIEAKPCSNSPPKVKKAPRVGPSNQPSTSARA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for BNC2-UHRF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneUHRF2chr9:16870644chr9:6420912ENST00000276893016194_28851.0803.0PCNP


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for BNC2-UHRF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for BNC2-UHRF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBNC2C0008925Cleft Palate1CTD_human
HgeneBNC2C0238506Congenital posterior urethral valves1GENOMICS_ENGLAND;ORPHANET
HgeneBNC2C0376634Craniofacial Abnormalities1CTD_human
HgeneBNC2C0919267ovarian neoplasm1CTD_human
HgeneBNC2C1140680Malignant neoplasm of ovary1CTD_human
HgeneBNC2C1837218Cleft palate, isolated1CTD_human