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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ZFP64-CPM (FusionGDB2 ID:100390) |
Fusion Gene Summary for ZFP64-CPM |
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Fusion gene information | Fusion gene name: ZFP64-CPM | Fusion gene ID: 100390 | Hgene | Tgene | Gene symbol | ZFP64 | CPM | Gene ID | 55734 | 1368 |
Gene name | ZFP64 zinc finger protein | carboxypeptidase M | |
Synonyms | ZNF338 | - | |
Cytomap | 20q13.2 | 12q15 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger protein 64zinc finger protein 338zinc finger protein 64 homolog | carboxypeptidase Mrenal carboxypeptidaseurinary carboxypeptidase B | |
Modification date | 20200327 | 20200313 | |
UniProtAcc | . | P14384 | |
Ensembl transtripts involved in fusion gene | ENST00000371518, ENST00000361387, ENST00000477786, ENST00000371523, ENST00000346617, ENST00000371515, ENST00000216923, | ENST00000546373, ENST00000551568, ENST00000338356, ENST00000549691, | |
Fusion gene scores | * DoF score | 7 X 8 X 4=224 | 48 X 16 X 10=7680 |
# samples | 8 | 45 | |
** MAII score | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(45/7680*10)=-4.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZFP64 [Title/Abstract] AND CPM [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ZFP64(50731735)-CPM(69237967), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS5.0 | N/A | CB054172 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
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Fusion Gene ORF analysis for ZFP64-CPM |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000371518 | ENST00000546373 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000371518 | ENST00000551568 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000371518 | ENST00000338356 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000371518 | ENST00000549691 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000361387 | ENST00000546373 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000361387 | ENST00000551568 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000361387 | ENST00000338356 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000361387 | ENST00000549691 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000477786 | ENST00000546373 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000477786 | ENST00000551568 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000477786 | ENST00000338356 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000477786 | ENST00000549691 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000371523 | ENST00000546373 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000371523 | ENST00000551568 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000371523 | ENST00000338356 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000371523 | ENST00000549691 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000346617 | ENST00000546373 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000346617 | ENST00000551568 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000346617 | ENST00000338356 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000346617 | ENST00000549691 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000371515 | ENST00000546373 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000371515 | ENST00000551568 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000371515 | ENST00000338356 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000371515 | ENST00000549691 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000216923 | ENST00000546373 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000216923 | ENST00000551568 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000216923 | ENST00000338356 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
intron-intron | ENST00000216923 | ENST00000549691 | ZFP64 | chr20 | 50731735 | - | CPM | chr12 | 69237967 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for ZFP64-CPM |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for ZFP64-CPM |
![]() FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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Hgene | Tgene |
. | CPM |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins. {ECO:0000269|PubMed:12457462}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for ZFP64-CPM |
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Fusion Gene PPI Analysis for ZFP64-CPM |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ZFP64-CPM |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ZFP64-CPM |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CPM | C0014175 | Endometriosis | 1 | CTD_human |
Tgene | CPM | C0037116 | Silicosis | 1 | CTD_human |
Tgene | CPM | C0269102 | Endometrioma | 1 | CTD_human |