FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ZFYVE28-CCDC149 (FusionGDB2 ID:100492)

Fusion Gene Summary for ZFYVE28-CCDC149

check button Fusion gene summary
Fusion gene informationFusion gene name: ZFYVE28-CCDC149
Fusion gene ID: 100492
HgeneTgene
Gene symbol

ZFYVE28

CCDC149

Gene ID

57732

91050

Gene namezinc finger FYVE-type containing 28coiled-coil domain containing 149
SynonymsLST2|LYST2|lst-2-
Cytomap

4p16.3

4p15.2

Type of geneprotein-codingprotein-coding
Descriptionlateral signaling target protein 2 homologhLst2lateral signaling target-2 homologzinc finger FYVE domain-containing protein 28zinc finger, FYVE domain containing 28coiled-coil domain-containing protein 149
Modification date2020031320200313
UniProtAcc.

Q6ZUS6

Ensembl transtripts involved in fusion geneENST00000290974, ENST00000511071, 
ENST00000515312, ENST00000515169, 
ENST00000509171, ENST00000503000, 
ENST00000508471, ENST00000505421, 
ENST00000504487, ENST00000428116, 
ENST00000389609, ENST00000502801, 
ENST00000508236, 
Fusion gene scores* DoF score7 X 4 X 6=1684 X 4 X 4=64
# samples 84
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZFYVE28 [Title/Abstract] AND CCDC149 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZFYVE28(2420012)-CCDC149(24878319), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZFYVE28 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCDC149 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DH-A669-01AZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
ChimerDB4LGGTCGA-DH-A669-01AZFYVE28chr4

2420012

-CCDC149chr4

24878319

-


Top

Fusion Gene ORF analysis for ZFYVE28-CCDC149

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000290974ENST00000504487ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-5UTRENST00000290974ENST00000428116ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-5UTRENST00000290974ENST00000389609ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-5UTRENST00000290974ENST00000502801ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-intronENST00000290974ENST00000508236ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
In-frameENST00000511071ENST00000504487ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-5UTRENST00000511071ENST00000428116ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-5UTRENST00000511071ENST00000389609ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-5UTRENST00000511071ENST00000502801ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-intronENST00000511071ENST00000508236ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-3CDSENST00000515312ENST00000504487ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-5UTRENST00000515312ENST00000428116ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-5UTRENST00000515312ENST00000389609ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-5UTRENST00000515312ENST00000502801ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-intronENST00000515312ENST00000508236ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-3CDSENST00000515169ENST00000504487ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-5UTRENST00000515169ENST00000428116ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-5UTRENST00000515169ENST00000389609ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-5UTRENST00000515169ENST00000502801ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-intronENST00000515169ENST00000508236ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
In-frameENST00000509171ENST00000504487ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-5UTRENST00000509171ENST00000428116ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-5UTRENST00000509171ENST00000389609ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-5UTRENST00000509171ENST00000502801ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-intronENST00000509171ENST00000508236ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
In-frameENST00000503000ENST00000504487ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-5UTRENST00000503000ENST00000428116ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-5UTRENST00000503000ENST00000389609ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-5UTRENST00000503000ENST00000502801ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
5CDS-intronENST00000503000ENST00000508236ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-3CDSENST00000508471ENST00000504487ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-5UTRENST00000508471ENST00000428116ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-5UTRENST00000508471ENST00000389609ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-5UTRENST00000508471ENST00000502801ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-intronENST00000508471ENST00000508236ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-3CDSENST00000505421ENST00000504487ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-5UTRENST00000505421ENST00000428116ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-5UTRENST00000505421ENST00000389609ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-5UTRENST00000505421ENST00000502801ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-
intron-intronENST00000505421ENST00000508236ZFYVE28chr4

2420012

-CCDC149chr4

24878319

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000290974ZFYVE28chr42420012-ENST00000504487CCDC149chr424878319-41783791121905597
ENST00000511071ZFYVE28chr42420012-ENST00000504487CCDC149chr424878319-4151352851878597
ENST00000509171ZFYVE28chr42420012-ENST00000504487CCDC149chr424878319-41663671001893597
ENST00000503000ZFYVE28chr42420012-ENST00000504487CCDC149chr424878319-4124325581851597

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000290974ENST00000504487ZFYVE28chr42420012-CCDC149chr424878319-0.0023650460.997635
ENST00000511071ENST00000504487ZFYVE28chr42420012-CCDC149chr424878319-0.002372880.9976271
ENST00000509171ENST00000504487ZFYVE28chr42420012-CCDC149chr424878319-0.0023772450.9976228
ENST00000503000ENST00000504487ZFYVE28chr42420012-CCDC149chr424878319-0.002331930.9976681

Top

Fusion Genomic Features for ZFYVE28-CCDC149


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ZFYVE28-CCDC149


check button Go to

FGviewer for the breakpoints of chr4:2420012-chr4:24878319

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCDC149

Q6ZUS6

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCDC149chr4:2420012chr4:24878319ENST00000389609113259_28621.0530.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC149chr4:2420012chr4:24878319ENST00000389609113385_41421.0530.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC149chr4:2420012chr4:24878319ENST00000428116051_199087.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC149chr4:2420012chr4:24878319ENST0000042811605259_286087.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC149chr4:2420012chr4:24878319ENST0000042811605385_414087.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC149chr4:2420012chr4:24878319ENST0000050280105259_28621.0142.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC149chr4:2420012chr4:24878319ENST0000050280105385_41421.0142.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC149chr4:2420012chr4:24878319ENST00000504487012259_28621.0530.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC149chr4:2420012chr4:24878319ENST00000504487012385_41421.0530.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC149chr4:2420012chr4:24878319ENST00000389609113205_20821.0530.0Compositional biasNote=Poly-Ser
TgeneCCDC149chr4:2420012chr4:24878319ENST0000042811605205_208087.0Compositional biasNote=Poly-Ser
TgeneCCDC149chr4:2420012chr4:24878319ENST0000050280105205_20821.0142.0Compositional biasNote=Poly-Ser
TgeneCCDC149chr4:2420012chr4:24878319ENST00000504487012205_20821.0530.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZFYVE28chr4:2420012chr4:24878319ENST00000290974-113817_87913.0888.0Zinc fingerFYVE-type
HgeneZFYVE28chr4:2420012chr4:24878319ENST00000503000-17817_87913.0288.0Zinc fingerFYVE-type
HgeneZFYVE28chr4:2420012chr4:24878319ENST00000509171-15817_87913.0173.0Zinc fingerFYVE-type
HgeneZFYVE28chr4:2420012chr4:24878319ENST00000511071-112817_87913.0858.0Zinc fingerFYVE-type
HgeneZFYVE28chr4:2420012chr4:24878319ENST00000515169-17817_8790164.0Zinc fingerFYVE-type
HgeneZFYVE28chr4:2420012chr4:24878319ENST00000515312-113817_8790818.0Zinc fingerFYVE-type
TgeneCCDC149chr4:2420012chr4:24878319ENST000003896091131_19921.0530.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC149chr4:2420012chr4:24878319ENST00000502801051_19921.0142.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC149chr4:2420012chr4:24878319ENST000005044870121_19921.0530.0Coiled coilOntology_term=ECO:0000255


Top

Fusion Gene Sequence for ZFYVE28-CCDC149


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000290974_ENST00000504487_TCGA-DH-A669-01A_ZFYVE28_chr4_2420012_-_CCDC149_chr4_24878319_length(transcript)=4178nt_BP=379nt
GTGCGGCGCGGGGCGGCCGTGACCAGCGGAGCGCTGGGTGTCAGTGAGCAGCGAGGAGCCGCGCGCCCCCGTGCCCGCGTCTGTCCGTGC
GCCCGAGCGCCCACTCCCGGGTCTGAGGTCTGCCCGGCGCGCCGCTTGCAGAGCATACTCAGGGCCGCGCACCTGCCCCGCGCACCTGCC
CGCCGCCCGCTCGGCGCTCCGGGCTTCGCTAGCCAGCCTCCCTGCGACAGCGCGGGGGCTCCGGCCGTGCCTCCGCGTCCGCCCCGCGCC
TCAGCCGGGCCCGGGCGCAGCGCTGCGGAGGGCGAGGGCCGCCCGGAGTCCGGCCAGGGCCGGCGCGGCGATGATGAACAGGTTCCGAAA
GTGGCTCTACAAACCCAAGTACCTGGTGTGTAAGAGGAAGCTGGAGAGTAAGAAGGAAGCCCTGCTGATCCTCTCCAAGGAGCTGGACAC
CTGTCAACAGGAAAGGGACCAGTACAAACTCATGGCCAATCAGCTCCGGGAGCGCCACCAGTCACTGAAGAAGAAGTACCGAGAGCTGAT
TGATGGAGATCCATCACTTCCTCCTGAAAAAAGGAAACAGGCTAATCTTGCACAACTATTGAGAGATTCTCAGGACCGAAATAAACATCT
GGGAGAAGAAATTAAAGAACTTCAGCAAAGGCTTGGAGAAGTCCAGGGCGACAACAAGCTCTTGAGGATGACGATTGCCAAACAAAGGCT
CGGAGACGAAGCAATCGGCGTGCGACACTTTGCAGCCCATGAGCGTGAAGACTTGGTGCAGCAGCTAGAGCGAGCTAAGGAACAGATTGA
GTCTCTGGAGCACGACCTGCAGGCTTCTGTGGACGAGCTTCAGGATGTTAAAGAAGAACGGTCTTCCTACCAGGACAAAGTGGAGAGGCT
CAACCAGGAGCTGAACCATATCCTGAGTGGGCACGAGAACCGCATCATTGACGTGGACGCCCTGTGTATGGAGAACAGGTACCTTCAAGA
GAGATTAAAGCAACTCCATGAAGAGGTCAACCTCTTGAAATCAAACATTGCCAAATACAAGAATGCTCTGGAGAGACGGAAAAACTCGAA
GGGCCAGGGTAAATCCAGCAGCAGTGCTCTGACAGGAGTCCTGTCTGCAAAGCAAGTTCAGGATCTGCTATCTGAGGATCATGGATGCAG
CCTCCCAGCTACTCCGCAGTCCATTTCTGACCTGAAATCTCTGGCAACAGCCCTGTTGGAAACAATCCACGAGAAAAACATGGTCATTCA
GCACCAGAGGCAAACCAACAAAATCCTAGGGAATCGGGTGGCTGAGCTGGAAAAAAAATTAAGAACTCTGGAAGTTTCTGGTTTGTGGAG
TCTTCCAGGGGGCAAGGACACCATACTGTTCAGCGACCCCACTCTTCCTAGTGGACAGAGGTCGAGATCCCCACTGCTGAAGTTTGTCGA
GCAGCCCACTGAGAACAAAGCAGATCCCAAGGATGGGGAGGCTCAGAAGCAAGAAGAAGATGAAAGTTGTGCCGCTGCTGAGGCGTTGAC
AGCGCCTGAGGATGCTGGGAGGCCCGCTGTCAACTCCCCAGCAAATCAGAGCCGCGGGAACCAATGCAAGCTCTTTCATCCTTCATTACC
CCAGTTACCTTCTGAGGAAGAAGTAAACAGCCTTGGGAGGGAAATAATTAAACTGACAAAGGAACAGGCAGCTGCAGAACTGGAAGAGGT
CAGAAGAGAGAGTCCCATAGAAGGTCAGAGGAGTGAGACGGGGCCAGCCCCGCCAGGCCTGGCCATCCAGGGGGAGCTCCCTAAATCTCA
CCTGGACTCCTTCGAGGCCAGCCGGCCAGCAGCCAAAGCTTCCACACCGGAAGACGGCAAAGGGATCCCAGAGGGCGGAGGCATGAGGAG
CACCGTGAAAACCTGAAGGGGAGAGGGATCTGACACAATGACACATTGAAAGCCCCAGAGAGGGTCAAGAATGAAGCATCGGAATGGTGC
GCTCACGTCGCCTTCTCCTGAAATACCTCCGAGTCTGCAAGTGAGAAAACGCACTGATCCTGTTGCAAACTGTGAATATTCTGATGATGC
CAGTACAGTTTGATTTATTAAATGTAGGTCCTCAAGCTTCTCAGTGTCATCTCTTTTCTGCCAGAGAGTGCTACTGTGAACAGGGCCAGG
CCCAGGAATCGTGTCCACCATATGGCTGGTTTTCAGCATCCGTCTTTCTGTCAGCTTTTGTTTTATCAGAGATAAGATGTTTTTGTATTA
GCATTTAATGTTGTCAATCAAAATTATGGGAAGAGCTAGAAACTGATGGGGTTTTTAATCAGGTCCCCATCTTGGTCAAGGTTAGGCAGC
TGGAGAGGAAGGTATAATTGAGCAAAACGTGTCCAGAGGACCCATGGCTGCACCCCATCAAGTCAGGGCCCAGGAGGACTGCCTGGCATG
GGTGTGCTTGGCATTGTGCCCACAGCACTGCTGTCGTGGTACAGACTGGCAGTTGGAAGGGGCCTTAAGCCGGCTGAGAAGTTTGGGCTT
CTGGGTTGAAATCCACAGCCCCGGTTGAGGCCTGTGTGCTGAGTGCCAGAGCTGGAGTTTTCTAGCTTGTAAATCTGGAGAATTAACTGA
TCTGAAGTGACTGGGAGGGGTGAGCATAAAAGCCGGGGAACAGGACTCCCAGTGGTGGTCTGGTTTTTTTTGTGAGATGAGATGAGAGCT
ACCACCTGGAAATGCTCATTCTCTGCATTCAGCCTGTCTCACATACAGGATTGTATGGCCATTTCAGGTTTGGGAAAGATCTACCTGCTG
GGAGCCAGTCTAGTTTCCTGCACCACCTGGAACTTCCAAACCCTTCACTCCTTCAACAGAATGTTGAGGCTGCCTCATTTGTGCCACCAA
GTACGGGAATCTTAAAGACAGAAACAGAGCTCATGACCTTTTATGGGAAAGAGAGAGGAAAACAAAACAACTTCACAACAGCATGGCAAG
GGGGGATGTGGAACCAAGGACATGATACAGGGATGGGAAAGGAGGGCATGCTCAATTCTAGCTGGTTCTTTCCTTTCAGATAAAAATGAG
CTTTTCTAGTTGGCATCCGGCACTGCAGAAAACTAAAAGTCATCCAGCCATAGCTTTTTCCTTCCCTGGAAAGCCTGAGACTAGATCCCA
AAGCTCAGAATGCCTCTGAGAACCAGAATCACTCCTTTGAGAGGCGCTCCTTGCAGGAAAAAGAGAGGCTCCCAGAGTGGTAGCCTCTCA
GTGAAAATGCATCCTAAAAATTCAATGTTTATACCAGGCTCATGACACTAAGATGTGACATCTGGACACGAGGGGTCAGCCACGTGGATA
CATCCCTCCCAGATTGCATCTCCAGGAATCACTCTGCTAGCAGAATGGGCGCCCCATCCCTTACTATGCTGCTCCTCCTCAAAGTGCAGC
CCAGAAGGACCCAGGCCTTTGATGCACATTGGGTGGGTCTCCCACTACTTTAGTTGAAATGGGAGCATGCTGGAGTCGGCGTTCTGTTGC
TTCTGGTGAGAAGGACATCCCATTGACCCCTGGCCACCAGGTCCAGTATTCCATCCTTCCTTCTGTCCCAGCCTATCGCCCTCCCCACCA
GGCCCACCCCCACAACTTCTCCTCAAGGGAGGTTGCTCCCGCAGCTGGAGGGCTTGCACAGACCAGCAGTCACAGAAATCATTCTTCCTG
CTGTACTGGGCCTTAACTGCCTGCAAATGTCCAGCACTACTGCATAGGATGCCAGAGCCACCGAAGGAAAACACAGCCAAGTTTAATAAT
AATAAAAGGAAAAATCTCAGCCTGCAGAACTCTGGTTTTGACCCACCATCGGCCAGATGCACATCTTCAGGGCCTGTTGAGCACCTTCTG
AAAAGCAGGGCTCGTAATAGACTCCAGCACATTCCATCAGAGTCAGGAAAACTGCAGTGAGTCCCAGAGAATCTAGGGTGCAGGGCAGGG
AGCAGGAGTCATAAGGAGTGATAACCTAAACTGTGTGTAGTCAGCGGGGAGGGTCTTATGTTATCAGGTGAAATGAGAGCCAGTAAGTTA
GTTGATCCTGTCACAGATATAACCCTGATAACACCCCATAGATACGCGACACGTGTGTCCTGCCCCTGCTTTCCCCATCCAACATGGTTC

>In-frame_ENST00000290974_ENST00000504487_TCGA-DH-A669-01A_ZFYVE28_chr4_2420012_-_CCDC149_chr4_24878319_length(amino acids)=597AA_start in transcript=112_stop in transcript=1905
MRSARRAACRAYSGPRTCPAHLPAARSALRASLASLPATARGLRPCLRVRPAPQPGPGAALRRARAARSPARAGAAMMNRFRKWLYKPKY
LVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKEL
QQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHI
LSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQS
ISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKA
DPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIE

--------------------------------------------------------------
>In-frame_ENST00000511071_ENST00000504487_TCGA-DH-A669-01A_ZFYVE28_chr4_2420012_-_CCDC149_chr4_24878319_length(transcript)=4151nt_BP=352nt
GGAGCGCTGGGTGTCAGTGAGCAGCGAGGAGCCGCGCGCCCCCGTGCCCGCGTCTGTCCGTGCGCCCGAGCGCCCACTCCCGGGTCTGAG
GTCTGCCCGGCGCGCCGCTTGCAGAGCATACTCAGGGCCGCGCACCTGCCCCGCGCACCTGCCCGCCGCCCGCTCGGCGCTCCGGGCTTC
GCTAGCCAGCCTCCCTGCGACAGCGCGGGGGCTCCGGCCGTGCCTCCGCGTCCGCCCCGCGCCTCAGCCGGGCCCGGGCGCAGCGCTGCG
GAGGGCGAGGGCCGCCCGGAGTCCGGCCAGGGCCGGCGCGGCGATGATGAACAGGTTCCGAAAGTGGCTCTACAAACCCAAGTACCTGGT
GTGTAAGAGGAAGCTGGAGAGTAAGAAGGAAGCCCTGCTGATCCTCTCCAAGGAGCTGGACACCTGTCAACAGGAAAGGGACCAGTACAA
ACTCATGGCCAATCAGCTCCGGGAGCGCCACCAGTCACTGAAGAAGAAGTACCGAGAGCTGATTGATGGAGATCCATCACTTCCTCCTGA
AAAAAGGAAACAGGCTAATCTTGCACAACTATTGAGAGATTCTCAGGACCGAAATAAACATCTGGGAGAAGAAATTAAAGAACTTCAGCA
AAGGCTTGGAGAAGTCCAGGGCGACAACAAGCTCTTGAGGATGACGATTGCCAAACAAAGGCTCGGAGACGAAGCAATCGGCGTGCGACA
CTTTGCAGCCCATGAGCGTGAAGACTTGGTGCAGCAGCTAGAGCGAGCTAAGGAACAGATTGAGTCTCTGGAGCACGACCTGCAGGCTTC
TGTGGACGAGCTTCAGGATGTTAAAGAAGAACGGTCTTCCTACCAGGACAAAGTGGAGAGGCTCAACCAGGAGCTGAACCATATCCTGAG
TGGGCACGAGAACCGCATCATTGACGTGGACGCCCTGTGTATGGAGAACAGGTACCTTCAAGAGAGATTAAAGCAACTCCATGAAGAGGT
CAACCTCTTGAAATCAAACATTGCCAAATACAAGAATGCTCTGGAGAGACGGAAAAACTCGAAGGGCCAGGGTAAATCCAGCAGCAGTGC
TCTGACAGGAGTCCTGTCTGCAAAGCAAGTTCAGGATCTGCTATCTGAGGATCATGGATGCAGCCTCCCAGCTACTCCGCAGTCCATTTC
TGACCTGAAATCTCTGGCAACAGCCCTGTTGGAAACAATCCACGAGAAAAACATGGTCATTCAGCACCAGAGGCAAACCAACAAAATCCT
AGGGAATCGGGTGGCTGAGCTGGAAAAAAAATTAAGAACTCTGGAAGTTTCTGGTTTGTGGAGTCTTCCAGGGGGCAAGGACACCATACT
GTTCAGCGACCCCACTCTTCCTAGTGGACAGAGGTCGAGATCCCCACTGCTGAAGTTTGTCGAGCAGCCCACTGAGAACAAAGCAGATCC
CAAGGATGGGGAGGCTCAGAAGCAAGAAGAAGATGAAAGTTGTGCCGCTGCTGAGGCGTTGACAGCGCCTGAGGATGCTGGGAGGCCCGC
TGTCAACTCCCCAGCAAATCAGAGCCGCGGGAACCAATGCAAGCTCTTTCATCCTTCATTACCCCAGTTACCTTCTGAGGAAGAAGTAAA
CAGCCTTGGGAGGGAAATAATTAAACTGACAAAGGAACAGGCAGCTGCAGAACTGGAAGAGGTCAGAAGAGAGAGTCCCATAGAAGGTCA
GAGGAGTGAGACGGGGCCAGCCCCGCCAGGCCTGGCCATCCAGGGGGAGCTCCCTAAATCTCACCTGGACTCCTTCGAGGCCAGCCGGCC
AGCAGCCAAAGCTTCCACACCGGAAGACGGCAAAGGGATCCCAGAGGGCGGAGGCATGAGGAGCACCGTGAAAACCTGAAGGGGAGAGGG
ATCTGACACAATGACACATTGAAAGCCCCAGAGAGGGTCAAGAATGAAGCATCGGAATGGTGCGCTCACGTCGCCTTCTCCTGAAATACC
TCCGAGTCTGCAAGTGAGAAAACGCACTGATCCTGTTGCAAACTGTGAATATTCTGATGATGCCAGTACAGTTTGATTTATTAAATGTAG
GTCCTCAAGCTTCTCAGTGTCATCTCTTTTCTGCCAGAGAGTGCTACTGTGAACAGGGCCAGGCCCAGGAATCGTGTCCACCATATGGCT
GGTTTTCAGCATCCGTCTTTCTGTCAGCTTTTGTTTTATCAGAGATAAGATGTTTTTGTATTAGCATTTAATGTTGTCAATCAAAATTAT
GGGAAGAGCTAGAAACTGATGGGGTTTTTAATCAGGTCCCCATCTTGGTCAAGGTTAGGCAGCTGGAGAGGAAGGTATAATTGAGCAAAA
CGTGTCCAGAGGACCCATGGCTGCACCCCATCAAGTCAGGGCCCAGGAGGACTGCCTGGCATGGGTGTGCTTGGCATTGTGCCCACAGCA
CTGCTGTCGTGGTACAGACTGGCAGTTGGAAGGGGCCTTAAGCCGGCTGAGAAGTTTGGGCTTCTGGGTTGAAATCCACAGCCCCGGTTG
AGGCCTGTGTGCTGAGTGCCAGAGCTGGAGTTTTCTAGCTTGTAAATCTGGAGAATTAACTGATCTGAAGTGACTGGGAGGGGTGAGCAT
AAAAGCCGGGGAACAGGACTCCCAGTGGTGGTCTGGTTTTTTTTGTGAGATGAGATGAGAGCTACCACCTGGAAATGCTCATTCTCTGCA
TTCAGCCTGTCTCACATACAGGATTGTATGGCCATTTCAGGTTTGGGAAAGATCTACCTGCTGGGAGCCAGTCTAGTTTCCTGCACCACC
TGGAACTTCCAAACCCTTCACTCCTTCAACAGAATGTTGAGGCTGCCTCATTTGTGCCACCAAGTACGGGAATCTTAAAGACAGAAACAG
AGCTCATGACCTTTTATGGGAAAGAGAGAGGAAAACAAAACAACTTCACAACAGCATGGCAAGGGGGGATGTGGAACCAAGGACATGATA
CAGGGATGGGAAAGGAGGGCATGCTCAATTCTAGCTGGTTCTTTCCTTTCAGATAAAAATGAGCTTTTCTAGTTGGCATCCGGCACTGCA
GAAAACTAAAAGTCATCCAGCCATAGCTTTTTCCTTCCCTGGAAAGCCTGAGACTAGATCCCAAAGCTCAGAATGCCTCTGAGAACCAGA
ATCACTCCTTTGAGAGGCGCTCCTTGCAGGAAAAAGAGAGGCTCCCAGAGTGGTAGCCTCTCAGTGAAAATGCATCCTAAAAATTCAATG
TTTATACCAGGCTCATGACACTAAGATGTGACATCTGGACACGAGGGGTCAGCCACGTGGATACATCCCTCCCAGATTGCATCTCCAGGA
ATCACTCTGCTAGCAGAATGGGCGCCCCATCCCTTACTATGCTGCTCCTCCTCAAAGTGCAGCCCAGAAGGACCCAGGCCTTTGATGCAC
ATTGGGTGGGTCTCCCACTACTTTAGTTGAAATGGGAGCATGCTGGAGTCGGCGTTCTGTTGCTTCTGGTGAGAAGGACATCCCATTGAC
CCCTGGCCACCAGGTCCAGTATTCCATCCTTCCTTCTGTCCCAGCCTATCGCCCTCCCCACCAGGCCCACCCCCACAACTTCTCCTCAAG
GGAGGTTGCTCCCGCAGCTGGAGGGCTTGCACAGACCAGCAGTCACAGAAATCATTCTTCCTGCTGTACTGGGCCTTAACTGCCTGCAAA
TGTCCAGCACTACTGCATAGGATGCCAGAGCCACCGAAGGAAAACACAGCCAAGTTTAATAATAATAAAAGGAAAAATCTCAGCCTGCAG
AACTCTGGTTTTGACCCACCATCGGCCAGATGCACATCTTCAGGGCCTGTTGAGCACCTTCTGAAAAGCAGGGCTCGTAATAGACTCCAG
CACATTCCATCAGAGTCAGGAAAACTGCAGTGAGTCCCAGAGAATCTAGGGTGCAGGGCAGGGAGCAGGAGTCATAAGGAGTGATAACCT
AAACTGTGTGTAGTCAGCGGGGAGGGTCTTATGTTATCAGGTGAAATGAGAGCCAGTAAGTTAGTTGATCCTGTCACAGATATAACCCTG
ATAACACCCCATAGATACGCGACACGTGTGTCCTGCCCCTGCTTTCCCCATCCAACATGGTTCTTCTGTTCCACAGACATTAAAGGGGCT

>In-frame_ENST00000511071_ENST00000504487_TCGA-DH-A669-01A_ZFYVE28_chr4_2420012_-_CCDC149_chr4_24878319_length(amino acids)=597AA_start in transcript=85_stop in transcript=1878
MRSARRAACRAYSGPRTCPAHLPAARSALRASLASLPATARGLRPCLRVRPAPQPGPGAALRRARAARSPARAGAAMMNRFRKWLYKPKY
LVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKEL
QQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHI
LSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQS
ISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKA
DPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIE

--------------------------------------------------------------
>In-frame_ENST00000509171_ENST00000504487_TCGA-DH-A669-01A_ZFYVE28_chr4_2420012_-_CCDC149_chr4_24878319_length(transcript)=4166nt_BP=367nt
GCGGCCGTGACCAGCGGAGCGCTGGGTGTCAGTGAGCAGCGAGGAGCCGCGCGCCCCCGTGCCCGCGTCTGTCCGTGCGCCCGAGCGCCC
ACTCCCGGGTCTGAGGTCTGCCCGGCGCGCCGCTTGCAGAGCATACTCAGGGCCGCGCACCTGCCCCGCGCACCTGCCCGCCGCCCGCTC
GGCGCTCCGGGCTTCGCTAGCCAGCCTCCCTGCGACAGCGCGGGGGCTCCGGCCGTGCCTCCGCGTCCGCCCCGCGCCTCAGCCGGGCCC
GGGCGCAGCGCTGCGGAGGGCGAGGGCCGCCCGGAGTCCGGCCAGGGCCGGCGCGGCGATGATGAACAGGTTCCGAAAGTGGCTCTACAA
ACCCAAGTACCTGGTGTGTAAGAGGAAGCTGGAGAGTAAGAAGGAAGCCCTGCTGATCCTCTCCAAGGAGCTGGACACCTGTCAACAGGA
AAGGGACCAGTACAAACTCATGGCCAATCAGCTCCGGGAGCGCCACCAGTCACTGAAGAAGAAGTACCGAGAGCTGATTGATGGAGATCC
ATCACTTCCTCCTGAAAAAAGGAAACAGGCTAATCTTGCACAACTATTGAGAGATTCTCAGGACCGAAATAAACATCTGGGAGAAGAAAT
TAAAGAACTTCAGCAAAGGCTTGGAGAAGTCCAGGGCGACAACAAGCTCTTGAGGATGACGATTGCCAAACAAAGGCTCGGAGACGAAGC
AATCGGCGTGCGACACTTTGCAGCCCATGAGCGTGAAGACTTGGTGCAGCAGCTAGAGCGAGCTAAGGAACAGATTGAGTCTCTGGAGCA
CGACCTGCAGGCTTCTGTGGACGAGCTTCAGGATGTTAAAGAAGAACGGTCTTCCTACCAGGACAAAGTGGAGAGGCTCAACCAGGAGCT
GAACCATATCCTGAGTGGGCACGAGAACCGCATCATTGACGTGGACGCCCTGTGTATGGAGAACAGGTACCTTCAAGAGAGATTAAAGCA
ACTCCATGAAGAGGTCAACCTCTTGAAATCAAACATTGCCAAATACAAGAATGCTCTGGAGAGACGGAAAAACTCGAAGGGCCAGGGTAA
ATCCAGCAGCAGTGCTCTGACAGGAGTCCTGTCTGCAAAGCAAGTTCAGGATCTGCTATCTGAGGATCATGGATGCAGCCTCCCAGCTAC
TCCGCAGTCCATTTCTGACCTGAAATCTCTGGCAACAGCCCTGTTGGAAACAATCCACGAGAAAAACATGGTCATTCAGCACCAGAGGCA
AACCAACAAAATCCTAGGGAATCGGGTGGCTGAGCTGGAAAAAAAATTAAGAACTCTGGAAGTTTCTGGTTTGTGGAGTCTTCCAGGGGG
CAAGGACACCATACTGTTCAGCGACCCCACTCTTCCTAGTGGACAGAGGTCGAGATCCCCACTGCTGAAGTTTGTCGAGCAGCCCACTGA
GAACAAAGCAGATCCCAAGGATGGGGAGGCTCAGAAGCAAGAAGAAGATGAAAGTTGTGCCGCTGCTGAGGCGTTGACAGCGCCTGAGGA
TGCTGGGAGGCCCGCTGTCAACTCCCCAGCAAATCAGAGCCGCGGGAACCAATGCAAGCTCTTTCATCCTTCATTACCCCAGTTACCTTC
TGAGGAAGAAGTAAACAGCCTTGGGAGGGAAATAATTAAACTGACAAAGGAACAGGCAGCTGCAGAACTGGAAGAGGTCAGAAGAGAGAG
TCCCATAGAAGGTCAGAGGAGTGAGACGGGGCCAGCCCCGCCAGGCCTGGCCATCCAGGGGGAGCTCCCTAAATCTCACCTGGACTCCTT
CGAGGCCAGCCGGCCAGCAGCCAAAGCTTCCACACCGGAAGACGGCAAAGGGATCCCAGAGGGCGGAGGCATGAGGAGCACCGTGAAAAC
CTGAAGGGGAGAGGGATCTGACACAATGACACATTGAAAGCCCCAGAGAGGGTCAAGAATGAAGCATCGGAATGGTGCGCTCACGTCGCC
TTCTCCTGAAATACCTCCGAGTCTGCAAGTGAGAAAACGCACTGATCCTGTTGCAAACTGTGAATATTCTGATGATGCCAGTACAGTTTG
ATTTATTAAATGTAGGTCCTCAAGCTTCTCAGTGTCATCTCTTTTCTGCCAGAGAGTGCTACTGTGAACAGGGCCAGGCCCAGGAATCGT
GTCCACCATATGGCTGGTTTTCAGCATCCGTCTTTCTGTCAGCTTTTGTTTTATCAGAGATAAGATGTTTTTGTATTAGCATTTAATGTT
GTCAATCAAAATTATGGGAAGAGCTAGAAACTGATGGGGTTTTTAATCAGGTCCCCATCTTGGTCAAGGTTAGGCAGCTGGAGAGGAAGG
TATAATTGAGCAAAACGTGTCCAGAGGACCCATGGCTGCACCCCATCAAGTCAGGGCCCAGGAGGACTGCCTGGCATGGGTGTGCTTGGC
ATTGTGCCCACAGCACTGCTGTCGTGGTACAGACTGGCAGTTGGAAGGGGCCTTAAGCCGGCTGAGAAGTTTGGGCTTCTGGGTTGAAAT
CCACAGCCCCGGTTGAGGCCTGTGTGCTGAGTGCCAGAGCTGGAGTTTTCTAGCTTGTAAATCTGGAGAATTAACTGATCTGAAGTGACT
GGGAGGGGTGAGCATAAAAGCCGGGGAACAGGACTCCCAGTGGTGGTCTGGTTTTTTTTGTGAGATGAGATGAGAGCTACCACCTGGAAA
TGCTCATTCTCTGCATTCAGCCTGTCTCACATACAGGATTGTATGGCCATTTCAGGTTTGGGAAAGATCTACCTGCTGGGAGCCAGTCTA
GTTTCCTGCACCACCTGGAACTTCCAAACCCTTCACTCCTTCAACAGAATGTTGAGGCTGCCTCATTTGTGCCACCAAGTACGGGAATCT
TAAAGACAGAAACAGAGCTCATGACCTTTTATGGGAAAGAGAGAGGAAAACAAAACAACTTCACAACAGCATGGCAAGGGGGGATGTGGA
ACCAAGGACATGATACAGGGATGGGAAAGGAGGGCATGCTCAATTCTAGCTGGTTCTTTCCTTTCAGATAAAAATGAGCTTTTCTAGTTG
GCATCCGGCACTGCAGAAAACTAAAAGTCATCCAGCCATAGCTTTTTCCTTCCCTGGAAAGCCTGAGACTAGATCCCAAAGCTCAGAATG
CCTCTGAGAACCAGAATCACTCCTTTGAGAGGCGCTCCTTGCAGGAAAAAGAGAGGCTCCCAGAGTGGTAGCCTCTCAGTGAAAATGCAT
CCTAAAAATTCAATGTTTATACCAGGCTCATGACACTAAGATGTGACATCTGGACACGAGGGGTCAGCCACGTGGATACATCCCTCCCAG
ATTGCATCTCCAGGAATCACTCTGCTAGCAGAATGGGCGCCCCATCCCTTACTATGCTGCTCCTCCTCAAAGTGCAGCCCAGAAGGACCC
AGGCCTTTGATGCACATTGGGTGGGTCTCCCACTACTTTAGTTGAAATGGGAGCATGCTGGAGTCGGCGTTCTGTTGCTTCTGGTGAGAA
GGACATCCCATTGACCCCTGGCCACCAGGTCCAGTATTCCATCCTTCCTTCTGTCCCAGCCTATCGCCCTCCCCACCAGGCCCACCCCCA
CAACTTCTCCTCAAGGGAGGTTGCTCCCGCAGCTGGAGGGCTTGCACAGACCAGCAGTCACAGAAATCATTCTTCCTGCTGTACTGGGCC
TTAACTGCCTGCAAATGTCCAGCACTACTGCATAGGATGCCAGAGCCACCGAAGGAAAACACAGCCAAGTTTAATAATAATAAAAGGAAA
AATCTCAGCCTGCAGAACTCTGGTTTTGACCCACCATCGGCCAGATGCACATCTTCAGGGCCTGTTGAGCACCTTCTGAAAAGCAGGGCT
CGTAATAGACTCCAGCACATTCCATCAGAGTCAGGAAAACTGCAGTGAGTCCCAGAGAATCTAGGGTGCAGGGCAGGGAGCAGGAGTCAT
AAGGAGTGATAACCTAAACTGTGTGTAGTCAGCGGGGAGGGTCTTATGTTATCAGGTGAAATGAGAGCCAGTAAGTTAGTTGATCCTGTC
ACAGATATAACCCTGATAACACCCCATAGATACGCGACACGTGTGTCCTGCCCCTGCTTTCCCCATCCAACATGGTTCTTCTGTTCCACA

>In-frame_ENST00000509171_ENST00000504487_TCGA-DH-A669-01A_ZFYVE28_chr4_2420012_-_CCDC149_chr4_24878319_length(amino acids)=597AA_start in transcript=100_stop in transcript=1893
MRSARRAACRAYSGPRTCPAHLPAARSALRASLASLPATARGLRPCLRVRPAPQPGPGAALRRARAARSPARAGAAMMNRFRKWLYKPKY
LVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKEL
QQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHI
LSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQS
ISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKA
DPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIE

--------------------------------------------------------------
>In-frame_ENST00000503000_ENST00000504487_TCGA-DH-A669-01A_ZFYVE28_chr4_2420012_-_CCDC149_chr4_24878319_length(transcript)=4124nt_BP=325nt
GGAGCCGCGCGCCCCCGTGCCCGCGTCTGTCCGTGCGCCCGAGCGCCCACTCCCGGGTCTGAGGTCTGCCCGGCGCGCCGCTTGCAGAGC
ATACTCAGGGCCGCGCACCTGCCCCGCGCACCTGCCCGCCGCCCGCTCGGCGCTCCGGGCTTCGCTAGCCAGCCTCCCTGCGACAGCGCG
GGGGCTCCGGCCGTGCCTCCGCGTCCGCCCCGCGCCTCAGCCGGGCCCGGGCGCAGCGCTGCGGAGGGCGAGGGCCGCCCGGAGTCCGGC
CAGGGCCGGCGCGGCGATGATGAACAGGTTCCGAAAGTGGCTCTACAAACCCAAGTACCTGGTGTGTAAGAGGAAGCTGGAGAGTAAGAA
GGAAGCCCTGCTGATCCTCTCCAAGGAGCTGGACACCTGTCAACAGGAAAGGGACCAGTACAAACTCATGGCCAATCAGCTCCGGGAGCG
CCACCAGTCACTGAAGAAGAAGTACCGAGAGCTGATTGATGGAGATCCATCACTTCCTCCTGAAAAAAGGAAACAGGCTAATCTTGCACA
ACTATTGAGAGATTCTCAGGACCGAAATAAACATCTGGGAGAAGAAATTAAAGAACTTCAGCAAAGGCTTGGAGAAGTCCAGGGCGACAA
CAAGCTCTTGAGGATGACGATTGCCAAACAAAGGCTCGGAGACGAAGCAATCGGCGTGCGACACTTTGCAGCCCATGAGCGTGAAGACTT
GGTGCAGCAGCTAGAGCGAGCTAAGGAACAGATTGAGTCTCTGGAGCACGACCTGCAGGCTTCTGTGGACGAGCTTCAGGATGTTAAAGA
AGAACGGTCTTCCTACCAGGACAAAGTGGAGAGGCTCAACCAGGAGCTGAACCATATCCTGAGTGGGCACGAGAACCGCATCATTGACGT
GGACGCCCTGTGTATGGAGAACAGGTACCTTCAAGAGAGATTAAAGCAACTCCATGAAGAGGTCAACCTCTTGAAATCAAACATTGCCAA
ATACAAGAATGCTCTGGAGAGACGGAAAAACTCGAAGGGCCAGGGTAAATCCAGCAGCAGTGCTCTGACAGGAGTCCTGTCTGCAAAGCA
AGTTCAGGATCTGCTATCTGAGGATCATGGATGCAGCCTCCCAGCTACTCCGCAGTCCATTTCTGACCTGAAATCTCTGGCAACAGCCCT
GTTGGAAACAATCCACGAGAAAAACATGGTCATTCAGCACCAGAGGCAAACCAACAAAATCCTAGGGAATCGGGTGGCTGAGCTGGAAAA
AAAATTAAGAACTCTGGAAGTTTCTGGTTTGTGGAGTCTTCCAGGGGGCAAGGACACCATACTGTTCAGCGACCCCACTCTTCCTAGTGG
ACAGAGGTCGAGATCCCCACTGCTGAAGTTTGTCGAGCAGCCCACTGAGAACAAAGCAGATCCCAAGGATGGGGAGGCTCAGAAGCAAGA
AGAAGATGAAAGTTGTGCCGCTGCTGAGGCGTTGACAGCGCCTGAGGATGCTGGGAGGCCCGCTGTCAACTCCCCAGCAAATCAGAGCCG
CGGGAACCAATGCAAGCTCTTTCATCCTTCATTACCCCAGTTACCTTCTGAGGAAGAAGTAAACAGCCTTGGGAGGGAAATAATTAAACT
GACAAAGGAACAGGCAGCTGCAGAACTGGAAGAGGTCAGAAGAGAGAGTCCCATAGAAGGTCAGAGGAGTGAGACGGGGCCAGCCCCGCC
AGGCCTGGCCATCCAGGGGGAGCTCCCTAAATCTCACCTGGACTCCTTCGAGGCCAGCCGGCCAGCAGCCAAAGCTTCCACACCGGAAGA
CGGCAAAGGGATCCCAGAGGGCGGAGGCATGAGGAGCACCGTGAAAACCTGAAGGGGAGAGGGATCTGACACAATGACACATTGAAAGCC
CCAGAGAGGGTCAAGAATGAAGCATCGGAATGGTGCGCTCACGTCGCCTTCTCCTGAAATACCTCCGAGTCTGCAAGTGAGAAAACGCAC
TGATCCTGTTGCAAACTGTGAATATTCTGATGATGCCAGTACAGTTTGATTTATTAAATGTAGGTCCTCAAGCTTCTCAGTGTCATCTCT
TTTCTGCCAGAGAGTGCTACTGTGAACAGGGCCAGGCCCAGGAATCGTGTCCACCATATGGCTGGTTTTCAGCATCCGTCTTTCTGTCAG
CTTTTGTTTTATCAGAGATAAGATGTTTTTGTATTAGCATTTAATGTTGTCAATCAAAATTATGGGAAGAGCTAGAAACTGATGGGGTTT
TTAATCAGGTCCCCATCTTGGTCAAGGTTAGGCAGCTGGAGAGGAAGGTATAATTGAGCAAAACGTGTCCAGAGGACCCATGGCTGCACC
CCATCAAGTCAGGGCCCAGGAGGACTGCCTGGCATGGGTGTGCTTGGCATTGTGCCCACAGCACTGCTGTCGTGGTACAGACTGGCAGTT
GGAAGGGGCCTTAAGCCGGCTGAGAAGTTTGGGCTTCTGGGTTGAAATCCACAGCCCCGGTTGAGGCCTGTGTGCTGAGTGCCAGAGCTG
GAGTTTTCTAGCTTGTAAATCTGGAGAATTAACTGATCTGAAGTGACTGGGAGGGGTGAGCATAAAAGCCGGGGAACAGGACTCCCAGTG
GTGGTCTGGTTTTTTTTGTGAGATGAGATGAGAGCTACCACCTGGAAATGCTCATTCTCTGCATTCAGCCTGTCTCACATACAGGATTGT
ATGGCCATTTCAGGTTTGGGAAAGATCTACCTGCTGGGAGCCAGTCTAGTTTCCTGCACCACCTGGAACTTCCAAACCCTTCACTCCTTC
AACAGAATGTTGAGGCTGCCTCATTTGTGCCACCAAGTACGGGAATCTTAAAGACAGAAACAGAGCTCATGACCTTTTATGGGAAAGAGA
GAGGAAAACAAAACAACTTCACAACAGCATGGCAAGGGGGGATGTGGAACCAAGGACATGATACAGGGATGGGAAAGGAGGGCATGCTCA
ATTCTAGCTGGTTCTTTCCTTTCAGATAAAAATGAGCTTTTCTAGTTGGCATCCGGCACTGCAGAAAACTAAAAGTCATCCAGCCATAGC
TTTTTCCTTCCCTGGAAAGCCTGAGACTAGATCCCAAAGCTCAGAATGCCTCTGAGAACCAGAATCACTCCTTTGAGAGGCGCTCCTTGC
AGGAAAAAGAGAGGCTCCCAGAGTGGTAGCCTCTCAGTGAAAATGCATCCTAAAAATTCAATGTTTATACCAGGCTCATGACACTAAGAT
GTGACATCTGGACACGAGGGGTCAGCCACGTGGATACATCCCTCCCAGATTGCATCTCCAGGAATCACTCTGCTAGCAGAATGGGCGCCC
CATCCCTTACTATGCTGCTCCTCCTCAAAGTGCAGCCCAGAAGGACCCAGGCCTTTGATGCACATTGGGTGGGTCTCCCACTACTTTAGT
TGAAATGGGAGCATGCTGGAGTCGGCGTTCTGTTGCTTCTGGTGAGAAGGACATCCCATTGACCCCTGGCCACCAGGTCCAGTATTCCAT
CCTTCCTTCTGTCCCAGCCTATCGCCCTCCCCACCAGGCCCACCCCCACAACTTCTCCTCAAGGGAGGTTGCTCCCGCAGCTGGAGGGCT
TGCACAGACCAGCAGTCACAGAAATCATTCTTCCTGCTGTACTGGGCCTTAACTGCCTGCAAATGTCCAGCACTACTGCATAGGATGCCA
GAGCCACCGAAGGAAAACACAGCCAAGTTTAATAATAATAAAAGGAAAAATCTCAGCCTGCAGAACTCTGGTTTTGACCCACCATCGGCC
AGATGCACATCTTCAGGGCCTGTTGAGCACCTTCTGAAAAGCAGGGCTCGTAATAGACTCCAGCACATTCCATCAGAGTCAGGAAAACTG
CAGTGAGTCCCAGAGAATCTAGGGTGCAGGGCAGGGAGCAGGAGTCATAAGGAGTGATAACCTAAACTGTGTGTAGTCAGCGGGGAGGGT
CTTATGTTATCAGGTGAAATGAGAGCCAGTAAGTTAGTTGATCCTGTCACAGATATAACCCTGATAACACCCCATAGATACGCGACACGT

>In-frame_ENST00000503000_ENST00000504487_TCGA-DH-A669-01A_ZFYVE28_chr4_2420012_-_CCDC149_chr4_24878319_length(amino acids)=597AA_start in transcript=58_stop in transcript=1851
MRSARRAACRAYSGPRTCPAHLPAARSALRASLASLPATARGLRPCLRVRPAPQPGPGAALRRARAARSPARAGAAMMNRFRKWLYKPKY
LVCKRKLESKKEALLILSKELDTCQQERDQYKLMANQLRERHQSLKKKYRELIDGDPSLPPEKRKQANLAQLLRDSQDRNKHLGEEIKEL
QQRLGEVQGDNKLLRMTIAKQRLGDEAIGVRHFAAHEREDLVQQLERAKEQIESLEHDLQASVDELQDVKEERSSYQDKVERLNQELNHI
LSGHENRIIDVDALCMENRYLQERLKQLHEEVNLLKSNIAKYKNALERRKNSKGQGKSSSSALTGVLSAKQVQDLLSEDHGCSLPATPQS
ISDLKSLATALLETIHEKNMVIQHQRQTNKILGNRVAELEKKLRTLEVSGLWSLPGGKDTILFSDPTLPSGQRSRSPLLKFVEQPTENKA
DPKDGEAQKQEEDESCAAAEALTAPEDAGRPAVNSPANQSRGNQCKLFHPSLPQLPSEEEVNSLGREIIKLTKEQAAAELEEVRRESPIE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ZFYVE28-CCDC149


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ZFYVE28-CCDC149


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ZFYVE28-CCDC149


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource