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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:ZMYM2-MTIF3 (FusionGDB2 ID:100657) |
Fusion Gene Summary for ZMYM2-MTIF3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ZMYM2-MTIF3 | Fusion gene ID: 100657 | Hgene | Tgene | Gene symbol | ZMYM2 | MTIF3 | Gene ID | 7750 | 219402 |
Gene name | zinc finger MYM-type containing 2 | mitochondrial translational initiation factor 3 | |
Synonyms | FIM|MYM|RAMP|SCLL|ZNF198 | IF3mt | |
Cytomap | 13q12.11 | 13q12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | zinc finger MYM-type protein 2fused in myeloproliferative disorders proteinrearranged in an atypical myeloproliferative disorderzinc finger protein 198zinc finger, MYM-type 2 | translation initiation factor IF-3, mitochondrialIF-3(Mt) | |
Modification date | 20200313 | 20200320 | |
UniProtAcc | . | Q9H2K0 | |
Ensembl transtripts involved in fusion gene | ENST00000382869, ENST00000382881, ENST00000382874, ENST00000382871, ENST00000382883, ENST00000494061, | ENST00000405591, ENST00000431572, ENST00000381116, ENST00000381120, ENST00000461838, | |
Fusion gene scores | * DoF score | 19 X 16 X 11=3344 | 4 X 4 X 4=64 |
# samples | 21 | 5 | |
** MAII score | log2(21/3344*10)=-3.99311361441476 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ZMYM2 [Title/Abstract] AND MTIF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ZMYM2(20580726)-MTIF3(28010030), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | ZMYM2-MTIF3 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ZMYM2-MTIF3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ZMYM2-MTIF3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MTIF3 | GO:0032790 | ribosome disassembly | 12095986 |
Tgene | MTIF3 | GO:0070124 | mitochondrial translational initiation | 12095986 |
Fusion gene breakpoints across ZMYM2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across MTIF3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | ESCA | TCGA-LN-A49K | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
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Fusion Gene ORF analysis for ZMYM2-MTIF3 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000382869 | ENST00000405591 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
In-frame | ENST00000382869 | ENST00000431572 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
Frame-shift | ENST00000382869 | ENST00000381116 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
Frame-shift | ENST00000382869 | ENST00000381120 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
5CDS-5UTR | ENST00000382869 | ENST00000461838 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
Frame-shift | ENST00000382881 | ENST00000405591 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
In-frame | ENST00000382881 | ENST00000431572 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
Frame-shift | ENST00000382881 | ENST00000381116 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
Frame-shift | ENST00000382881 | ENST00000381120 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
5CDS-5UTR | ENST00000382881 | ENST00000461838 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
Frame-shift | ENST00000382874 | ENST00000405591 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
In-frame | ENST00000382874 | ENST00000431572 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
Frame-shift | ENST00000382874 | ENST00000381116 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
Frame-shift | ENST00000382874 | ENST00000381120 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
5CDS-5UTR | ENST00000382874 | ENST00000461838 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
Frame-shift | ENST00000382871 | ENST00000405591 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
In-frame | ENST00000382871 | ENST00000431572 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
Frame-shift | ENST00000382871 | ENST00000381116 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
Frame-shift | ENST00000382871 | ENST00000381120 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
5CDS-5UTR | ENST00000382871 | ENST00000461838 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
intron-3CDS | ENST00000382883 | ENST00000405591 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
intron-3CDS | ENST00000382883 | ENST00000431572 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
intron-3CDS | ENST00000382883 | ENST00000381116 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
intron-3CDS | ENST00000382883 | ENST00000381120 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
intron-5UTR | ENST00000382883 | ENST00000461838 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
intron-3CDS | ENST00000494061 | ENST00000405591 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
intron-3CDS | ENST00000494061 | ENST00000431572 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
intron-3CDS | ENST00000494061 | ENST00000381116 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
intron-3CDS | ENST00000494061 | ENST00000381120 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
intron-5UTR | ENST00000494061 | ENST00000461838 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000382869 | ZMYM2 | chr13 | 20580726 | + | ENST00000431572 | MTIF3 | chr13 | 28010030 | - | 2018 | 1763 | 197 | 1981 | 594 |
ENST00000382881 | ZMYM2 | chr13 | 20580726 | + | ENST00000431572 | MTIF3 | chr13 | 28010030 | - | 1750 | 1495 | 190 | 1713 | 507 |
ENST00000382874 | ZMYM2 | chr13 | 20580726 | + | ENST00000431572 | MTIF3 | chr13 | 28010030 | - | 1957 | 1702 | 190 | 1920 | 576 |
ENST00000382871 | ZMYM2 | chr13 | 20580726 | + | ENST00000431572 | MTIF3 | chr13 | 28010030 | - | 1952 | 1697 | 185 | 1915 | 576 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000382869 | ENST00000431572 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - | 0.000342416 | 0.99965763 |
ENST00000382881 | ENST00000431572 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - | 0.000389204 | 0.99961084 |
ENST00000382874 | ENST00000431572 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - | 0.000357471 | 0.9996425 |
ENST00000382871 | ENST00000431572 | ZMYM2 | chr13 | 20580726 | + | MTIF3 | chr13 | 28010030 | - | 0.000342168 | 0.99965787 |
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Fusion Genomic Features for ZMYM2-MTIF3 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ZMYM2-MTIF3 |
Go to FGviewer for the breakpoints of chr13:20580726-chr13:28010030 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | MTIF3 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins. {ECO:0000269|PubMed:12095986}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382869 | + | 6 | 25 | 352_386 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 1 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382869 | + | 6 | 25 | 398_436 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 2 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382869 | + | 6 | 25 | 445_480 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 3 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382871 | + | 7 | 26 | 352_386 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 1 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382871 | + | 7 | 26 | 398_436 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 2 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382871 | + | 7 | 26 | 445_480 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 3 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382874 | + | 7 | 26 | 352_386 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 1 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382874 | + | 7 | 26 | 398_436 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 2 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382874 | + | 7 | 26 | 445_480 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 3 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382881 | + | 7 | 8 | 352_386 | 417.0 | 463.0 | Zinc finger | Note=MYM-type 1 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382869 | + | 6 | 25 | 491_549 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 4 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382869 | + | 6 | 25 | 559_597 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 5 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382869 | + | 6 | 25 | 605_652 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 6 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382869 | + | 6 | 25 | 660_694 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 7 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382869 | + | 6 | 25 | 701_740 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 8 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382869 | + | 6 | 25 | 747_781 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 9 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382871 | + | 7 | 26 | 491_549 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 4 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382871 | + | 7 | 26 | 559_597 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 5 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382871 | + | 7 | 26 | 605_652 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 6 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382871 | + | 7 | 26 | 660_694 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 7 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382871 | + | 7 | 26 | 701_740 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 8 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382871 | + | 7 | 26 | 747_781 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 9 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382874 | + | 7 | 26 | 491_549 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 4 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382874 | + | 7 | 26 | 559_597 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 5 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382874 | + | 7 | 26 | 605_652 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 6 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382874 | + | 7 | 26 | 660_694 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 7 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382874 | + | 7 | 26 | 701_740 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 8 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382874 | + | 7 | 26 | 747_781 | 504.0 | 1378.0 | Zinc finger | Note=MYM-type 9 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382881 | + | 7 | 8 | 398_436 | 417.0 | 463.0 | Zinc finger | Note=MYM-type 2 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382881 | + | 7 | 8 | 445_480 | 417.0 | 463.0 | Zinc finger | Note=MYM-type 3 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382881 | + | 7 | 8 | 491_549 | 417.0 | 463.0 | Zinc finger | Note=MYM-type 4 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382881 | + | 7 | 8 | 559_597 | 417.0 | 463.0 | Zinc finger | Note=MYM-type 5 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382881 | + | 7 | 8 | 605_652 | 417.0 | 463.0 | Zinc finger | Note=MYM-type 6 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382881 | + | 7 | 8 | 660_694 | 417.0 | 463.0 | Zinc finger | Note=MYM-type 7 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382881 | + | 7 | 8 | 701_740 | 417.0 | 463.0 | Zinc finger | Note=MYM-type 8 |
Hgene | ZMYM2 | chr13:20580726 | chr13:28010030 | ENST00000382881 | + | 7 | 8 | 747_781 | 417.0 | 463.0 | Zinc finger | Note=MYM-type 9 |
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Fusion Gene Sequence for ZMYM2-MTIF3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000382869_ENST00000431572_TCGA-LN-A49K_ZMYM2_chr13_20580726_+_MTIF3_chr13_28010030_length(transcript)=2018nt_BP=1763nt AGCGCGCGGAGGGCGGGGCCTCCCCGGGCTCGGCCGCGCCGCCGCCTCCTCCGCCTCCTCCTCCTCACCAGCGCTAAAGCCGGGACTGGA CCGAGCGGAGTTGTGCGTGTCGCCGAAGGGGGGTGGGCCGGGGGAGGGGAGGTTCGTTCCGCGGAGCCCCAGCCAGAACCGGGACCAAGA ATCGCCTTCAGCCCTGTCTGGTGCATCCTTGGCAGAAAGTGAGGAGGAAAACACCCCCATTGTTCTTTGGCATGGACACAAGTTCAGTGG GAGGATTAGAATTGACTGATCAGACTCCTGTTTTATTAGGGAGTACGGCCATGGCAACTAGTCTCACGAATGTAGGAAACTCATTTAGTG GTCCAGCTAATCCTTTAGTGTCTAGATCTAATAAGTTTCAGAACTCGTCAGTGGAAGATGATGATGATGTTGTTTTTATCGAACCTGTAC AACCTCCCCCACCTTCTGTACCAGTGGTAGCTGATCAAAGAACCATAACATTTACATCATCAAAAAATGAAGAACTACAAGGAAATGATT CCAAAATTACTCCTTCCTCAAAAGAGTTGGCATCTCAGAAGGGAAGTGTAAGTGAGACAATTGTCATTGATGATGAAGAGGACATGGAAA CAAATCAAGGGCAAGAGAAAAATTCCTCCAATTTTATTGAACGAAGACCTCCTGAGACTAAAAACAGAACCAATGATGTGGATTTCTCCA CTTCCAGTTTTTCAAGAAGTAAGGTAAATGCAGGAATGGGTAATAGTGGTATCACCACAGAACCAGACTCTGAAATTCAGATTGCTAATG TTACAACTTTAGAAACAGGTGTAAGCTCTGTGAATGATGGCCAATTAGAAAATACTGACGGGCGAGATATGAACTTAATGATTACACATG TAACATCACTGCAGAATACCAACTTGGGAGATGTCTCTAACGGACTGCAGTCAAGTAATTTTGGTGTTAATATACAAACATACACCCCAT CTTTAACTTCACAGACCAAGACTGGAGTAGGACCTTTTAATCCTGGTAGAATGAATGTGGCAGGAGACGTTTTTCAGAATGGAGAATCTG CAACTCATCATAATCCTGATTCTTGGATCTCCCAGTCAGCTTCATTTCCCCGTAATCAGAAACAACCAGGGGTGGACTCTTTATCACCAG TGGCCTCACTTCCTAAACAGATTTTCCAGCCGTCTGTCCAACAGCAGCCTACTAAACCAGTTAAAGTCACTTGTGCAAACTGCAAAAAAC CTTTACAGAAGGGCCAGACAGCTTATCAACGAAAAGGATCAGCTCACCTCTTTTGTTCTACCACCTGCCTTTCTTCCTTCTCCCACAAGC CTGCTCCAAAGAAACTCTGTGTTATGTGTAAAAAAGATATAACTACAATGAAAGGAACCATTGTTGCTCAAGTGGATTCAAGTGAGTCCT TCCAGGAATTCTGTAGTACATCTTGTTTATCTCTCTATGAAGACAAACAGAATCCTACTAAAGGAGCTCTAAATAAATCAAGATGTACAA TCTGTGGTAAACTAACTGAGATTCGCCATGAAGTCAGCTTTAAAAATATGACTCATAAGCTGTGCAGTGACCACTGCTTTAATAGATATA GAATGGCCAATGGTTTAATAATGAATTGCTGTGAACAGTGTGGAGAGTACTTGCCCAGTAAAGGTGCTGGAAATAATGTTCTGGTGATTG ATGGTCAACAGAAAAGATTTTGCTGTCAAAGTTGTGTCAGTGAATACAAACAGGAGGAGATATTTCATCAAATACTCCAGACTATGCCTG GAATAGCTACATTCTCATCTAGGCCACAAGCTGTTCAAGGAGGAAAAGCTTTAATGTGTGTTCTTCGTGCTTTCAGCAAAAATGAGGAGA AGGCATATAAAGAAACTCAAGAGACCCAGGAAAGAGACACTTTGAACAAAGACCATGGAAATGATAAGGAATCAAATGTTCTGCATCAGT >In-frame_ENST00000382869_ENST00000431572_TCGA-LN-A49K_ZMYM2_chr13_20580726_+_MTIF3_chr13_28010030_length(amino acids)=594AA_start in transcript=197_stop in transcript=1981 MVHPWQKVRRKTPPLFFGMDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDVVFIEPVQPPPPS VPVVADQRTITFTSSKNEELQGNDSKITPSSKELASQKGSVSETIVIDDEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSFSR SKVNAGMGNSGITTEPDSEIQIANVTTLETGVSSVNDGQLENTDGRDMNLMITHVTSLQNTNLGDVSNGLQSSNFGVNIQTYTPSLTSQT KTGVGPFNPGRMNVAGDVFQNGESATHHNPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQPSVQQQPTKPVKVTCANCKKPLQKGQ TAYQRKGSAHLFCSTTCLSSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLYEDKQNPTKGALNKSRCTICGKLT EIRHEVSFKNMTHKLCSDHCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQQKRFCCQSCVSEYKQEEIFHQILQTMPGIATFS -------------------------------------------------------------- >In-frame_ENST00000382881_ENST00000431572_TCGA-LN-A49K_ZMYM2_chr13_20580726_+_MTIF3_chr13_28010030_length(transcript)=1750nt_BP=1495nt GGAGGGCGGGGCCTCCCCGGGCTCGGCCGCGCCGCCGCCTCCTCCGCCTCCTCCTCCTCACCAGCGCTAAAGCCGGGACTGGACCGAGCG GAGTTGTGCGTGTCGCCGAAGGGGGGTGGGCCGGGGGAGGGGAGGTTCGTTCCGCGGAGCCCCAGCCAGAACCGGGACCAAGAATCGCCT TCAGCCCTGTCTGGTGCATCCTTGGCAGAAAGTGAGGAGGAAAACACCCCCATTGTTCTTTGGCATGGACACAAGTTCAGTGGGAGGATT AGAATTGACTGATCAGACTCCTGTTTTATTAGGGAGTACGGCCATGGCAACTAGTCTCACGAATGTAGGAAACTCATTTAGTGGTCCAGC TAATCCTTTAGTGTCTAGATCTAATAAGTTTCAGAACTCGTCAGTGGAAGATGATGATGATGTTGTTTTTATCGAACCTGTACAACCTCC CCCACCTTCTGTACCAGTGGTAGCTGATCAAAGAACCATAACATTTACATCATCAAAAAATGAAGAACTACAAGGAAATGATTCCAAAAT TACTCCTTCCTCAAAAGAGTTGGCATCTCAGAAGGGAAGTGTAAGTGAGACAATTGTCATTGATGATGAAGAGGACATGGAAACAAATCA AGGGCAAGAGAAAAATTCCTCCAATTTTATTGAACGAAGACCTCCTGAGACTAAAAACAGAACCAATGATGTGGATTTCTCCACTTCCAG TTTTTCAAGAAGTAAGACCAAGACTGGAGTAGGACCTTTTAATCCTGGTAGAATGAATGTGGCAGGAGACGTTTTTCAGAATGGAGAATC TGCAACTCATCATAATCCTGATTCTTGGATCTCCCAGTCAGCTTCATTTCCCCGTAATCAGAAACAACCAGGGGTGGACTCTTTATCACC AGTGGCCTCACTTCCTAAACAGATTTTCCAGCCGTCTGTCCAACAGCAGCCTACTAAACCAGTTAAAGTCACTTGTGCAAACTGCAAAAA ACCTTTACAGAAGGGCCAGACAGCTTATCAACGAAAAGGATCAGCTCACCTCTTTTGTTCTACCACCTGCCTTTCTTCCTTCTCCCACAA GCCTGCTCCAAAGAAACTCTGTGTTATGTGTAAAAAAGATATAACTACAATGAAAGGAACCATTGTTGCTCAAGTGGATTCAAGTGAGTC CTTCCAGGAATTCTGTAGTACATCTTGTTTATCTCTCTATGAAGACAAACAGAATCCTACTAAAGGAGCTCTAAATAAATCAAGATGTAC AATCTGTGGTAAACTAACTGAGATTCGCCATGAAGTCAGCTTTAAAAATATGACTCATAAGCTGTGCAGTGACCACTGCTTTAATAGATA TAGAATGGCCAATGGTTTAATAATGAATTGCTGTGAACAGTGTGGAGAGTACTTGCCCAGTAAAGGTGCTGGAAATAATGTTCTGGTGAT TGATGGTCAACAGAAAAGATTTTGCTGTCAAAGTTGTGTCAGTGAATACAAACAGGAGGAGATATTTCATCAAATACTCCAGACTATGCC TGGAATAGCTACATTCTCATCTAGGCCACAAGCTGTTCAAGGAGGAAAAGCTTTAATGTGTGTTCTTCGTGCTTTCAGCAAAAATGAGGA GAAGGCATATAAAGAAACTCAAGAGACCCAGGAAAGAGACACTTTGAACAAAGACCATGGAAATGATAAGGAATCAAATGTTCTGCATCA >In-frame_ENST00000382881_ENST00000431572_TCGA-LN-A49K_ZMYM2_chr13_20580726_+_MTIF3_chr13_28010030_length(amino acids)=507AA_start in transcript=190_stop in transcript=1713 MVHPWQKVRRKTPPLFFGMDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDVVFIEPVQPPPPS VPVVADQRTITFTSSKNEELQGNDSKITPSSKELASQKGSVSETIVIDDEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSFSR SKTKTGVGPFNPGRMNVAGDVFQNGESATHHNPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQPSVQQQPTKPVKVTCANCKKPLQ KGQTAYQRKGSAHLFCSTTCLSSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLYEDKQNPTKGALNKSRCTICG KLTEIRHEVSFKNMTHKLCSDHCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQQKRFCCQSCVSEYKQEEIFHQILQTMPGIA -------------------------------------------------------------- >In-frame_ENST00000382874_ENST00000431572_TCGA-LN-A49K_ZMYM2_chr13_20580726_+_MTIF3_chr13_28010030_length(transcript)=1957nt_BP=1702nt CCGCCGCCTCCTCCGCCTCCTCCTCCTCACCAGCGCTAAAGCCGGGACTGGACCGAGCGGAGTTGACCAAGAATCGCCTTCAGCCCTGTC TGGTGCATCCTTGGCAGAAAGTGAGGAGGAAAACACCCCCATTGTTAGATGAGGTCTTAATCATGGAACATTTGAAGTCACGTAAAGAAG GTTCTTTGGCATGGACACAAGTTCAGTGGGAGGATTAGAATTGACTGATCAGACTCCTGTTTTATTAGGGAGTACGGCCATGGCAACTAG TCTCACGAATGTAGGAAACTCATTTAGTGGTCCAGCTAATCCTTTAGTGTCTAGATCTAATAAGTTTCAGAACTCGTCAGTGGAAGATGA TGATGATGTTGTTTTTATCGAACCTGTACAACCTCCCCCACCTTCTGTACCAGTGGTAGCTGATCAAAGAACCATAACATTTACATCATC AAAAAATGAAGAACTACAAGGAAATGATTCCAAAATTACTCCTTCCTCAAAAGAGTTGGCATCTCAGAAGGGAAGTGTAAGTGAGACAAT TGTCATTGATGATGAAGAGGACATGGAAACAAATCAAGGGCAAGAGAAAAATTCCTCCAATTTTATTGAACGAAGACCTCCTGAGACTAA AAACAGAACCAATGATGTGGATTTCTCCACTTCCAGTTTTTCAAGAAGTAAGGTAAATGCAGGAATGGGTAATAGTGGTATCACCACAGA ACCAGACTCTGAAATTCAGATTGCTAATGTTACAACTTTAGAAACAGGTGTAAGCTCTGTGAATGATGGCCAATTAGAAAATACTGACGG GCGAGATATGAACTTAATGATTACACATGTAACATCACTGCAGAATACCAACTTGGGAGATGTCTCTAACGGACTGCAGTCAAGTAATTT TGGTGTTAATATACAAACATACACCCCATCTTTAACTTCACAGACCAAGACTGGAGTAGGACCTTTTAATCCTGGTAGAATGAATGTGGC AGGAGACGTTTTTCAGAATGGAGAATCTGCAACTCATCATAATCCTGATTCTTGGATCTCCCAGTCAGCTTCATTTCCCCGTAATCAGAA ACAACCAGGGGTGGACTCTTTATCACCAGTGGCCTCACTTCCTAAACAGATTTTCCAGCCGTCTGTCCAACAGCAGCCTACTAAACCAGT TAAAGTCACTTGTGCAAACTGCAAAAAACCTTTACAGAAGGGCCAGACAGCTTATCAACGAAAAGGATCAGCTCACCTCTTTTGTTCTAC CACCTGCCTTTCTTCCTTCTCCCACAAGCCTGCTCCAAAGAAACTCTGTGTTATGTGTAAAAAAGATATAACTACAATGAAAGGAACCAT TGTTGCTCAAGTGGATTCAAGTGAGTCCTTCCAGGAATTCTGTAGTACATCTTGTTTATCTCTCTATGAAGACAAACAGAATCCTACTAA AGGAGCTCTAAATAAATCAAGATGTACAATCTGTGGTAAACTAACTGAGATTCGCCATGAAGTCAGCTTTAAAAATATGACTCATAAGCT GTGCAGTGACCACTGCTTTAATAGATATAGAATGGCCAATGGTTTAATAATGAATTGCTGTGAACAGTGTGGAGAGTACTTGCCCAGTAA AGGTGCTGGAAATAATGTTCTGGTGATTGATGGTCAACAGAAAAGATTTTGCTGTCAAAGTTGTGTCAGTGAATACAAACAGGAGGAGAT ATTTCATCAAATACTCCAGACTATGCCTGGAATAGCTACATTCTCATCTAGGCCACAAGCTGTTCAAGGAGGAAAAGCTTTAATGTGTGT TCTTCGTGCTTTCAGCAAAAATGAGGAGAAGGCATATAAAGAAACTCAAGAGACCCAGGAAAGAGACACTTTGAACAAAGACCATGGAAA >In-frame_ENST00000382874_ENST00000431572_TCGA-LN-A49K_ZMYM2_chr13_20580726_+_MTIF3_chr13_28010030_length(amino acids)=576AA_start in transcript=190_stop in transcript=1920 MDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDVVFIEPVQPPPPSVPVVADQRTITFTSSKNE ELQGNDSKITPSSKELASQKGSVSETIVIDDEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSFSRSKVNAGMGNSGITTEPDS EIQIANVTTLETGVSSVNDGQLENTDGRDMNLMITHVTSLQNTNLGDVSNGLQSSNFGVNIQTYTPSLTSQTKTGVGPFNPGRMNVAGDV FQNGESATHHNPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQPSVQQQPTKPVKVTCANCKKPLQKGQTAYQRKGSAHLFCSTTCL SSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLYEDKQNPTKGALNKSRCTICGKLTEIRHEVSFKNMTHKLCSD HCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQQKRFCCQSCVSEYKQEEIFHQILQTMPGIATFSSRPQAVQGGKALMCVLRA -------------------------------------------------------------- >In-frame_ENST00000382871_ENST00000431572_TCGA-LN-A49K_ZMYM2_chr13_20580726_+_MTIF3_chr13_28010030_length(transcript)=1952nt_BP=1697nt CGAAGGGGGGTGGGCCGGGGGAGGGGAGGTTCGTTCCGCGGAGCCCCAGCCAGAACCGGGACCAAGAATCGCCTTCAGCCCTGTCTGGTG CATCCTTGGCAGAAAGTGAGGAGGAAAACACCCCCATTGTTAGATGAGGTCTTAATCATGGAACATTTGAAGTCACGTAAAGAAGGTTCT TTGGCATGGACACAAGTTCAGTGGGAGGATTAGAATTGACTGATCAGACTCCTGTTTTATTAGGGAGTACGGCCATGGCAACTAGTCTCA CGAATGTAGGAAACTCATTTAGTGGTCCAGCTAATCCTTTAGTGTCTAGATCTAATAAGTTTCAGAACTCGTCAGTGGAAGATGATGATG ATGTTGTTTTTATCGAACCTGTACAACCTCCCCCACCTTCTGTACCAGTGGTAGCTGATCAAAGAACCATAACATTTACATCATCAAAAA ATGAAGAACTACAAGGAAATGATTCCAAAATTACTCCTTCCTCAAAAGAGTTGGCATCTCAGAAGGGAAGTGTAAGTGAGACAATTGTCA TTGATGATGAAGAGGACATGGAAACAAATCAAGGGCAAGAGAAAAATTCCTCCAATTTTATTGAACGAAGACCTCCTGAGACTAAAAACA GAACCAATGATGTGGATTTCTCCACTTCCAGTTTTTCAAGAAGTAAGGTAAATGCAGGAATGGGTAATAGTGGTATCACCACAGAACCAG ACTCTGAAATTCAGATTGCTAATGTTACAACTTTAGAAACAGGTGTAAGCTCTGTGAATGATGGCCAATTAGAAAATACTGACGGGCGAG ATATGAACTTAATGATTACACATGTAACATCACTGCAGAATACCAACTTGGGAGATGTCTCTAACGGACTGCAGTCAAGTAATTTTGGTG TTAATATACAAACATACACCCCATCTTTAACTTCACAGACCAAGACTGGAGTAGGACCTTTTAATCCTGGTAGAATGAATGTGGCAGGAG ACGTTTTTCAGAATGGAGAATCTGCAACTCATCATAATCCTGATTCTTGGATCTCCCAGTCAGCTTCATTTCCCCGTAATCAGAAACAAC CAGGGGTGGACTCTTTATCACCAGTGGCCTCACTTCCTAAACAGATTTTCCAGCCGTCTGTCCAACAGCAGCCTACTAAACCAGTTAAAG TCACTTGTGCAAACTGCAAAAAACCTTTACAGAAGGGCCAGACAGCTTATCAACGAAAAGGATCAGCTCACCTCTTTTGTTCTACCACCT GCCTTTCTTCCTTCTCCCACAAGCCTGCTCCAAAGAAACTCTGTGTTATGTGTAAAAAAGATATAACTACAATGAAAGGAACCATTGTTG CTCAAGTGGATTCAAGTGAGTCCTTCCAGGAATTCTGTAGTACATCTTGTTTATCTCTCTATGAAGACAAACAGAATCCTACTAAAGGAG CTCTAAATAAATCAAGATGTACAATCTGTGGTAAACTAACTGAGATTCGCCATGAAGTCAGCTTTAAAAATATGACTCATAAGCTGTGCA GTGACCACTGCTTTAATAGATATAGAATGGCCAATGGTTTAATAATGAATTGCTGTGAACAGTGTGGAGAGTACTTGCCCAGTAAAGGTG CTGGAAATAATGTTCTGGTGATTGATGGTCAACAGAAAAGATTTTGCTGTCAAAGTTGTGTCAGTGAATACAAACAGGAGGAGATATTTC ATCAAATACTCCAGACTATGCCTGGAATAGCTACATTCTCATCTAGGCCACAAGCTGTTCAAGGAGGAAAAGCTTTAATGTGTGTTCTTC GTGCTTTCAGCAAAAATGAGGAGAAGGCATATAAAGAAACTCAAGAGACCCAGGAAAGAGACACTTTGAACAAAGACCATGGAAATGATA >In-frame_ENST00000382871_ENST00000431572_TCGA-LN-A49K_ZMYM2_chr13_20580726_+_MTIF3_chr13_28010030_length(amino acids)=576AA_start in transcript=185_stop in transcript=1915 MDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDVVFIEPVQPPPPSVPVVADQRTITFTSSKNE ELQGNDSKITPSSKELASQKGSVSETIVIDDEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSFSRSKVNAGMGNSGITTEPDS EIQIANVTTLETGVSSVNDGQLENTDGRDMNLMITHVTSLQNTNLGDVSNGLQSSNFGVNIQTYTPSLTSQTKTGVGPFNPGRMNVAGDV FQNGESATHHNPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQPSVQQQPTKPVKVTCANCKKPLQKGQTAYQRKGSAHLFCSTTCL SSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLYEDKQNPTKGALNKSRCTICGKLTEIRHEVSFKNMTHKLCSD HCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQQKRFCCQSCVSEYKQEEIFHQILQTMPGIATFSSRPQAVQGGKALMCVLRA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ZMYM2-MTIF3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ZMYM2-MTIF3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ZMYM2-MTIF3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ZMYM2 | C0020796 | Profound Mental Retardation | 1 | CTD_human |
Hgene | ZMYM2 | C0025363 | Mental Retardation, Psychosocial | 1 | CTD_human |
Hgene | ZMYM2 | C0027022 | Myeloproliferative disease | 1 | CTD_human |
Hgene | ZMYM2 | C0917816 | Mental deficiency | 1 | CTD_human |
Hgene | ZMYM2 | C3714756 | Intellectual Disability | 1 | CTD_human |