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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZMYM4-MANEAL (FusionGDB2 ID:100674)

Fusion Gene Summary for ZMYM4-MANEAL

check button Fusion gene summary
Fusion gene informationFusion gene name: ZMYM4-MANEAL
Fusion gene ID: 100674
HgeneTgene
Gene symbol

ZMYM4

MANEAL

Gene ID

9202

149175

Gene namezinc finger MYM-type containing 4mannosidase endo-alpha like
SynonymsCDIR|MYM|ZNF198L3|ZNF262-
Cytomap

1p34.3

1p34.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger MYM-type protein 4cell death inhibiting RNAzinc finger protein 262zinc finger, MYM-type 4glycoprotein endo-alpha-1,2-mannosidase-like protein
Modification date2020031320200313
UniProtAcc.

Q5VSG8

Ensembl transtripts involved in fusion geneENST00000373297, ENST00000314607, 
ENST00000482131, 		ENST00000373045, 
ENST00000397631, ENST00000525897, 
ENST00000329006, 
Fusion gene scores* DoF score14 X 8 X 10=11202 X 2 X 2=8
# samples 152
** MAII scorelog2(15/1120*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: ZMYM4 [Title/Abstract] AND MANEAL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZMYM4(35791006)-MANEAL(38261409), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZMYM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MANEAL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-5414-01AZMYM4chr1

35791006

+MANEALchr1

38261409

+


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Fusion Gene ORF analysis for ZMYM4-MANEAL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373297ENST00000373045ZMYM4chr1

35791006

+MANEALchr1

38261409

+
In-frameENST00000373297ENST00000397631ZMYM4chr1

35791006

+MANEALchr1

38261409

+
5CDS-5UTRENST00000373297ENST00000525897ZMYM4chr1

35791006

+MANEALchr1

38261409

+
5CDS-5UTRENST00000373297ENST00000329006ZMYM4chr1

35791006

+MANEALchr1

38261409

+
In-frameENST00000314607ENST00000373045ZMYM4chr1

35791006

+MANEALchr1

38261409

+
In-frameENST00000314607ENST00000397631ZMYM4chr1

35791006

+MANEALchr1

38261409

+
5CDS-5UTRENST00000314607ENST00000525897ZMYM4chr1

35791006

+MANEALchr1

38261409

+
5CDS-5UTRENST00000314607ENST00000329006ZMYM4chr1

35791006

+MANEALchr1

38261409

+
intron-3CDSENST00000482131ENST00000373045ZMYM4chr1

35791006

+MANEALchr1

38261409

+
intron-3CDSENST00000482131ENST00000397631ZMYM4chr1

35791006

+MANEALchr1

38261409

+
intron-5UTRENST00000482131ENST00000525897ZMYM4chr1

35791006

+MANEALchr1

38261409

+
intron-5UTRENST00000482131ENST00000329006ZMYM4chr1

35791006

+MANEALchr1

38261409

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373297ZMYM4chr135791006+ENST00000373045MANEALchr138261409+191916580988302
ENST00000373297ZMYM4chr135791006+ENST00000397631MANEALchr138261409+1642165699295134
ENST00000314607ZMYM4chr135791006+ENST00000373045MANEALchr138261409+191916580988302
ENST00000314607ZMYM4chr135791006+ENST00000397631MANEALchr138261409+1642165699295134

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373297ENST00000373045ZMYM4chr135791006+MANEALchr138261409+0.001650240.9983498
ENST00000373297ENST00000397631ZMYM4chr135791006+MANEALchr138261409+0.033696830.9663031
ENST00000314607ENST00000373045ZMYM4chr135791006+MANEALchr138261409+0.001650240.9983498
ENST00000314607ENST00000397631ZMYM4chr135791006+MANEALchr138261409+0.033696830.9663031

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Fusion Genomic Features for ZMYM4-MANEAL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZMYM4chr135791006+MANEALchr138261408+2.27E-091
ZMYM4chr135791006+MANEALchr138261408+2.27E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZMYM4-MANEAL


check button Go to

FGviewer for the breakpoints of chr1:35791006-chr1:38261409

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MANEAL

Q5VSG8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMANEALchr1:35791006chr1:38261409ENST000003290060232_950236.0Compositional biasNote=Pro-rich
TgeneMANEALchr1:35791006chr1:38261409ENST00000329006023_70236.0Compositional biasNote=Poly-Arg
TgeneMANEALchr1:35791006chr1:38261409ENST00000329006021_80236.0Topological domainCytoplasmic
TgeneMANEALchr1:35791006chr1:38261409ENST000003290060230_4570236.0Topological domainLumenal
TgeneMANEALchr1:35791006chr1:38261409ENST00000329006029_290236.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYM4chr1:35791006chr1:38261409ENST00000314607+230362_40228.3333333333333321549.0Zinc fingerNote=MYM-type 1
HgeneZMYM4chr1:35791006chr1:38261409ENST00000314607+230414_45728.3333333333333321549.0Zinc fingerNote=MYM-type 2
HgeneZMYM4chr1:35791006chr1:38261409ENST00000314607+230464_49928.3333333333333321549.0Zinc fingerNote=MYM-type 3
HgeneZMYM4chr1:35791006chr1:38261409ENST00000314607+230510_54428.3333333333333321549.0Zinc fingerNote=MYM-type 4
HgeneZMYM4chr1:35791006chr1:38261409ENST00000314607+230554_59228.3333333333333321549.0Zinc fingerNote=MYM-type 5
HgeneZMYM4chr1:35791006chr1:38261409ENST00000314607+230600_63128.3333333333333321549.0Zinc fingerNote=MYM-type 6
HgeneZMYM4chr1:35791006chr1:38261409ENST00000314607+230708_74228.3333333333333321549.0Zinc fingerNote=MYM-type 7
HgeneZMYM4chr1:35791006chr1:38261409ENST00000314607+230749_78828.3333333333333321549.0Zinc fingerNote=MYM-type 8
HgeneZMYM4chr1:35791006chr1:38261409ENST00000314607+230795_82928.3333333333333321549.0Zinc fingerNote=MYM-type 9
HgeneZMYM4chr1:35791006chr1:38261409ENST00000373297+228362_40228.3333333333333321460.0Zinc fingerNote=MYM-type 1
HgeneZMYM4chr1:35791006chr1:38261409ENST00000373297+228414_45728.3333333333333321460.0Zinc fingerNote=MYM-type 2
HgeneZMYM4chr1:35791006chr1:38261409ENST00000373297+228464_49928.3333333333333321460.0Zinc fingerNote=MYM-type 3
HgeneZMYM4chr1:35791006chr1:38261409ENST00000373297+228510_54428.3333333333333321460.0Zinc fingerNote=MYM-type 4
HgeneZMYM4chr1:35791006chr1:38261409ENST00000373297+228554_59228.3333333333333321460.0Zinc fingerNote=MYM-type 5
HgeneZMYM4chr1:35791006chr1:38261409ENST00000373297+228600_63128.3333333333333321460.0Zinc fingerNote=MYM-type 6
HgeneZMYM4chr1:35791006chr1:38261409ENST00000373297+228708_74228.3333333333333321460.0Zinc fingerNote=MYM-type 7
HgeneZMYM4chr1:35791006chr1:38261409ENST00000373297+228749_78828.3333333333333321460.0Zinc fingerNote=MYM-type 8
HgeneZMYM4chr1:35791006chr1:38261409ENST00000373297+228795_82928.3333333333333321460.0Zinc fingerNote=MYM-type 9
TgeneMANEALchr1:35791006chr1:38261409ENST000003730450432_95183.33333333333334458.0Compositional biasNote=Pro-rich
TgeneMANEALchr1:35791006chr1:38261409ENST00000373045043_7183.33333333333334458.0Compositional biasNote=Poly-Arg
TgeneMANEALchr1:35791006chr1:38261409ENST000003976310432_95183.33333333333334251.0Compositional biasNote=Pro-rich
TgeneMANEALchr1:35791006chr1:38261409ENST00000397631043_7183.33333333333334251.0Compositional biasNote=Poly-Arg
TgeneMANEALchr1:35791006chr1:38261409ENST00000373045041_8183.33333333333334458.0Topological domainCytoplasmic
TgeneMANEALchr1:35791006chr1:38261409ENST000003730450430_457183.33333333333334458.0Topological domainLumenal
TgeneMANEALchr1:35791006chr1:38261409ENST00000397631041_8183.33333333333334251.0Topological domainCytoplasmic
TgeneMANEALchr1:35791006chr1:38261409ENST000003976310430_457183.33333333333334251.0Topological domainLumenal
TgeneMANEALchr1:35791006chr1:38261409ENST00000373045049_29183.33333333333334458.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneMANEALchr1:35791006chr1:38261409ENST00000397631049_29183.33333333333334251.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for ZMYM4-MANEAL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000373297_ENST00000373045_TCGA-06-5414-01A_ZMYM4_chr1_35791006_+_MANEAL_chr1_38261409_length(transcript)=1919nt_BP=165nt
AGTGTGGGCGGGGGCCGGGGGGCCGAGAGGTACCGCCGCCACCGCGCGGGGAGCCGCAGCGGTTCCGAGCGGGGCCCAACATGGCGGAGA
GAGAGGTGGAGTCCGGCCCCCGAAAGAGGTTTGAACAAAAAAGTGGTGCAGTTTTTGATGAAATTGTAGAGAACTGCGTCCTGGTCCTGT
CCTGGTACCCACCTGGCATGGCTGATGATAACGGGGAGCCCTCAGATGACCTGGTGCCCGCCATTCTGGACACCGCCCATCAGTACAGCA
TCCAGGTGGCCTTCCACATCCAACCCTACAAGGGCCGGGATGACATCACTGTACATGACAACATCAAGTACATCATTGACACGTATGGCT
CCCATGGTGCATTTTACCGCTATAAGAACAGCATGGGCAAGAGCCTCCCACTCTTTTATATCTACGACTCATACCTGACGTCCCCTGAGG
CCTGGGCCCACCTCCTGACACCAAACGGGCCCCATTCGATCCGCAACACGCCCTACGATGGGGTCTTCATAGCGCTGCTGGTGGAGGAGG
GCCACACCCACGATATCCTGGCCGCCGGATTTGACGGCATGTACACCTACTTTGCCTCCAATGGTTTCTCCTTTGGTTCTTCCCATCAGA
ACTGGAAAGCTGTGAAGAACTTTTGTGATGCCAACAACCTCATGTTCATCCCCAGTGTGGGGCCTGGCTACATAGACACCAGCATTCGGC
CCTGGAACAACCACAATACGCGCAACAGGGTCAATGGCAAGTACTATGAGACGGCCCTGCAGGCGGCCCTGACAGTGAGGCCCGAGATCG
TTTCCATTACCTCCTTCAATGAGTGGCACGAGGGCACCCAGATTGAGAAGGCCATTCCCAAGAAGACACCCACCCGCCTGTATTTGGACT
ACCTGCCTCACCAGCCCAGCCTGTACCTGGAGCTGACACGCCGCTGGGCGGAGCACTTCATCAAAGAGAAGGAGCAGTGGCTCATGTGAG
GGGCCTGTAAATGGGCGTGAGGTGCTGATGTCCTTGCCTTGCTGGAAGATGTCACCATGTGGGGTTCAGCTGAGGTTGTAGCCACTCACT
CGTTCCCAGGTCAGAGGTCAGCAGATGGGTGTTTCTGGGTGGGCCGTCAGGCATGGGCCTGTGCAACACAGAGCCCGTTCCTCAGGCGAG
TGGTGCTGAGGTGCTCTGTGGTGATGGGAACGGCAGAGGCTGGCAGGTGACTGAACTTAGCCCAGGGCAGCTCCACATCCTGGGAACACT
TTCATGTAACCCCTTCTAGTTTTGAACTCTGCAGCAGGCTGGTGCTGTGTAGTGGCCACCCAGTCACCACCCTTGGAAGGGTGTCAGGGT
CTGGGCTCGCATGCACCCTGCTCCCTTCTGCCAGCCTGCATCCTCTCCTCAGGCCTCCTTCCCACATCATCTGTCTTCTCTAAGTTAGGG
AACCATATTTGAGACTTTCAAAAAGGGAACTTCTAGGTTTAAGCTCCTCCCAGTAGATTCCTGAACCCAATTATCAGGAAATCATCCTGA
GCACTCACAGGTTCATTTAACACTCACTCATCAAGCACCTTCCTATGTGCTAGGTGCTGGGGAAAACTTGACCAAGGAAGAGTTCCTGTC
CTGAAGCTTCCAGGACCCAGCTTTCCTTTTCTGGTGTGGCCTTGTAGCTAGTGCCTGGGCACAGGTGTTTTTCTTTTTGCAGTTTTACCT
AGTGCTGGGAGTTCAGTTCTTTTTCCTCTAGAAAAATACCTCTGTGCTCCAGAGCCTAATTTTTCCCAGATGCATATTTAGCTCTAGGGA
GAGGACTAGGAGGAAATCCCCCTCCCTTTAGCTGCCTGAACTGACTGAGGCCCACTCACTAGAGCCATGTTCAGTGCTACTGTGATTAGT

>In-frame_ENST00000373297_ENST00000373045_TCGA-06-5414-01A_ZMYM4_chr1_35791006_+_MANEAL_chr1_38261409_length(amino acids)=302AA_start in transcript=80_stop in transcript=988
MAEREVESGPRKRFEQKSGAVFDEIVENCVLVLSWYPPGMADDNGEPSDDLVPAILDTAHQYSIQVAFHIQPYKGRDDITVHDNIKYIID
TYGSHGAFYRYKNSMGKSLPLFYIYDSYLTSPEAWAHLLTPNGPHSIRNTPYDGVFIALLVEEGHTHDILAAGFDGMYTYFASNGFSFGS
SHQNWKAVKNFCDANNLMFIPSVGPGYIDTSIRPWNNHNTRNRVNGKYYETALQAALTVRPEIVSITSFNEWHEGTQIEKAIPKKTPTRL

--------------------------------------------------------------
>In-frame_ENST00000373297_ENST00000397631_TCGA-06-5414-01A_ZMYM4_chr1_35791006_+_MANEAL_chr1_38261409_length(transcript)=1642nt_BP=165nt
AGTGTGGGCGGGGGCCGGGGGGCCGAGAGGTACCGCCGCCACCGCGCGGGGAGCCGCAGCGGTTCCGAGCGGGGCCCAACATGGCGGAGA
GAGAGGTGGAGTCCGGCCCCCGAAAGAGGTTTGAACAAAAAAGTGGTGCAGTTTTTGATGAAATTGTAGAGAACTGCGTCCTGGTCCTGT
CCTGGTACCCACCTGGCATGGCTGATGATAACGGGGAGCCCTCAGATGACCTGGTGCCCGCCATTCTGGACACCGCCCATCAGTACAGCA
TCCAGGTGGCCTTCCACATCCAACCCTACAAGGGCCGGGATGACATCACTGTACATGACAACATCAAGTACATCATTGACACAACTGGAA
AGCTGTGAAGAACTTTTGTGATGCCAACAACCTCATGTTCATCCCCAGTGTGGGGCCTGGCTACATAGACACCAGCATTCGGCCCTGGAA
CAACCACAATACGCGCAACAGGGTCAATGGCAAGTACTATGAGACGGCCCTGCAGGCGGCCCTGACAGTGAGGCCCGAGATCGTTTCCAT
TACCTCCTTCAATGAGTGGCACGAGGGCACCCAGATTGAGAAGGCCATTCCCAAGAAGACACCCACCCGCCTGTATTTGGACTACCTGCC
TCACCAGCCCAGCCTGTACCTGGAGCTGACACGCCGCTGGGCGGAGCACTTCATCAAAGAGAAGGAGCAGTGGCTCATGTGAGGGGCCTG
TAAATGGGCGTGAGGTGCTGATGTCCTTGCCTTGCTGGAAGATGTCACCATGTGGGGTTCAGCTGAGGTTGTAGCCACTCACTCGTTCCC
AGGTCAGAGGTCAGCAGATGGGTGTTTCTGGGTGGGCCGTCAGGCATGGGCCTGTGCAACACAGAGCCCGTTCCTCAGGCGAGTGGTGCT
GAGGTGCTCTGTGGTGATGGGAACGGCAGAGGCTGGCAGGTGACTGAACTTAGCCCAGGGCAGCTCCACATCCTGGGAACACTTTCATGT
AACCCCTTCTAGTTTTGAACTCTGCAGCAGGCTGGTGCTGTGTAGTGGCCACCCAGTCACCACCCTTGGAAGGGTGTCAGGGTCTGGGCT
CGCATGCACCCTGCTCCCTTCTGCCAGCCTGCATCCTCTCCTCAGGCCTCCTTCCCACATCATCTGTCTTCTCTAAGTTAGGGAACCATA
TTTGAGACTTTCAAAAAGGGAACTTCTAGGTTTAAGCTCCTCCCAGTAGATTCCTGAACCCAATTATCAGGAAATCATCCTGAGCACTCA
CAGGTTCATTTAACACTCACTCATCAAGCACCTTCCTATGTGCTAGGTGCTGGGGAAAACTTGACCAAGGAAGAGTTCCTGTCCTGAAGC
TTCCAGGACCCAGCTTTCCTTTTCTGGTGTGGCCTTGTAGCTAGTGCCTGGGCACAGGTGTTTTTCTTTTTGCAGTTTTACCTAGTGCTG
GGAGTTCAGTTCTTTTTCCTCTAGAAAAATACCTCTGTGCTCCAGAGCCTAATTTTTCCCAGATGCATATTTAGCTCTAGGGAGAGGACT
AGGAGGAAATCCCCCTCCCTTTAGCTGCCTGAACTGACTGAGGCCCACTCACTAGAGCCATGTTCAGTGCTACTGTGATTAGTAGTAATT

>In-frame_ENST00000373297_ENST00000397631_TCGA-06-5414-01A_ZMYM4_chr1_35791006_+_MANEAL_chr1_38261409_length(amino acids)=134AA_start in transcript=699_stop in transcript=295
MLLLFDEVLRPAACQLQVQAGLVRQVVQIQAGGCLLGNGLLNLGALVPLIEGGNGNDLGPHCQGRLQGRLIVLAIDPVARIVVVPGPNAG

--------------------------------------------------------------
>In-frame_ENST00000314607_ENST00000373045_TCGA-06-5414-01A_ZMYM4_chr1_35791006_+_MANEAL_chr1_38261409_length(transcript)=1919nt_BP=165nt
AGTGTGGGCGGGGGCCGGGGGGCCGAGAGGTACCGCCGCCACCGCGCGGGGAGCCGCAGCGGTTCCGAGCGGGGCCCAACATGGCGGAGA
GAGAGGTGGAGTCCGGCCCCCGAAAGAGGTTTGAACAAAAAAGTGGTGCAGTTTTTGATGAAATTGTAGAGAACTGCGTCCTGGTCCTGT
CCTGGTACCCACCTGGCATGGCTGATGATAACGGGGAGCCCTCAGATGACCTGGTGCCCGCCATTCTGGACACCGCCCATCAGTACAGCA
TCCAGGTGGCCTTCCACATCCAACCCTACAAGGGCCGGGATGACATCACTGTACATGACAACATCAAGTACATCATTGACACGTATGGCT
CCCATGGTGCATTTTACCGCTATAAGAACAGCATGGGCAAGAGCCTCCCACTCTTTTATATCTACGACTCATACCTGACGTCCCCTGAGG
CCTGGGCCCACCTCCTGACACCAAACGGGCCCCATTCGATCCGCAACACGCCCTACGATGGGGTCTTCATAGCGCTGCTGGTGGAGGAGG
GCCACACCCACGATATCCTGGCCGCCGGATTTGACGGCATGTACACCTACTTTGCCTCCAATGGTTTCTCCTTTGGTTCTTCCCATCAGA
ACTGGAAAGCTGTGAAGAACTTTTGTGATGCCAACAACCTCATGTTCATCCCCAGTGTGGGGCCTGGCTACATAGACACCAGCATTCGGC
CCTGGAACAACCACAATACGCGCAACAGGGTCAATGGCAAGTACTATGAGACGGCCCTGCAGGCGGCCCTGACAGTGAGGCCCGAGATCG
TTTCCATTACCTCCTTCAATGAGTGGCACGAGGGCACCCAGATTGAGAAGGCCATTCCCAAGAAGACACCCACCCGCCTGTATTTGGACT
ACCTGCCTCACCAGCCCAGCCTGTACCTGGAGCTGACACGCCGCTGGGCGGAGCACTTCATCAAAGAGAAGGAGCAGTGGCTCATGTGAG
GGGCCTGTAAATGGGCGTGAGGTGCTGATGTCCTTGCCTTGCTGGAAGATGTCACCATGTGGGGTTCAGCTGAGGTTGTAGCCACTCACT
CGTTCCCAGGTCAGAGGTCAGCAGATGGGTGTTTCTGGGTGGGCCGTCAGGCATGGGCCTGTGCAACACAGAGCCCGTTCCTCAGGCGAG
TGGTGCTGAGGTGCTCTGTGGTGATGGGAACGGCAGAGGCTGGCAGGTGACTGAACTTAGCCCAGGGCAGCTCCACATCCTGGGAACACT
TTCATGTAACCCCTTCTAGTTTTGAACTCTGCAGCAGGCTGGTGCTGTGTAGTGGCCACCCAGTCACCACCCTTGGAAGGGTGTCAGGGT
CTGGGCTCGCATGCACCCTGCTCCCTTCTGCCAGCCTGCATCCTCTCCTCAGGCCTCCTTCCCACATCATCTGTCTTCTCTAAGTTAGGG
AACCATATTTGAGACTTTCAAAAAGGGAACTTCTAGGTTTAAGCTCCTCCCAGTAGATTCCTGAACCCAATTATCAGGAAATCATCCTGA
GCACTCACAGGTTCATTTAACACTCACTCATCAAGCACCTTCCTATGTGCTAGGTGCTGGGGAAAACTTGACCAAGGAAGAGTTCCTGTC
CTGAAGCTTCCAGGACCCAGCTTTCCTTTTCTGGTGTGGCCTTGTAGCTAGTGCCTGGGCACAGGTGTTTTTCTTTTTGCAGTTTTACCT
AGTGCTGGGAGTTCAGTTCTTTTTCCTCTAGAAAAATACCTCTGTGCTCCAGAGCCTAATTTTTCCCAGATGCATATTTAGCTCTAGGGA
GAGGACTAGGAGGAAATCCCCCTCCCTTTAGCTGCCTGAACTGACTGAGGCCCACTCACTAGAGCCATGTTCAGTGCTACTGTGATTAGT

>In-frame_ENST00000314607_ENST00000373045_TCGA-06-5414-01A_ZMYM4_chr1_35791006_+_MANEAL_chr1_38261409_length(amino acids)=302AA_start in transcript=80_stop in transcript=988
MAEREVESGPRKRFEQKSGAVFDEIVENCVLVLSWYPPGMADDNGEPSDDLVPAILDTAHQYSIQVAFHIQPYKGRDDITVHDNIKYIID
TYGSHGAFYRYKNSMGKSLPLFYIYDSYLTSPEAWAHLLTPNGPHSIRNTPYDGVFIALLVEEGHTHDILAAGFDGMYTYFASNGFSFGS
SHQNWKAVKNFCDANNLMFIPSVGPGYIDTSIRPWNNHNTRNRVNGKYYETALQAALTVRPEIVSITSFNEWHEGTQIEKAIPKKTPTRL

--------------------------------------------------------------
>In-frame_ENST00000314607_ENST00000397631_TCGA-06-5414-01A_ZMYM4_chr1_35791006_+_MANEAL_chr1_38261409_length(transcript)=1642nt_BP=165nt
AGTGTGGGCGGGGGCCGGGGGGCCGAGAGGTACCGCCGCCACCGCGCGGGGAGCCGCAGCGGTTCCGAGCGGGGCCCAACATGGCGGAGA
GAGAGGTGGAGTCCGGCCCCCGAAAGAGGTTTGAACAAAAAAGTGGTGCAGTTTTTGATGAAATTGTAGAGAACTGCGTCCTGGTCCTGT
CCTGGTACCCACCTGGCATGGCTGATGATAACGGGGAGCCCTCAGATGACCTGGTGCCCGCCATTCTGGACACCGCCCATCAGTACAGCA
TCCAGGTGGCCTTCCACATCCAACCCTACAAGGGCCGGGATGACATCACTGTACATGACAACATCAAGTACATCATTGACACAACTGGAA
AGCTGTGAAGAACTTTTGTGATGCCAACAACCTCATGTTCATCCCCAGTGTGGGGCCTGGCTACATAGACACCAGCATTCGGCCCTGGAA
CAACCACAATACGCGCAACAGGGTCAATGGCAAGTACTATGAGACGGCCCTGCAGGCGGCCCTGACAGTGAGGCCCGAGATCGTTTCCAT
TACCTCCTTCAATGAGTGGCACGAGGGCACCCAGATTGAGAAGGCCATTCCCAAGAAGACACCCACCCGCCTGTATTTGGACTACCTGCC
TCACCAGCCCAGCCTGTACCTGGAGCTGACACGCCGCTGGGCGGAGCACTTCATCAAAGAGAAGGAGCAGTGGCTCATGTGAGGGGCCTG
TAAATGGGCGTGAGGTGCTGATGTCCTTGCCTTGCTGGAAGATGTCACCATGTGGGGTTCAGCTGAGGTTGTAGCCACTCACTCGTTCCC
AGGTCAGAGGTCAGCAGATGGGTGTTTCTGGGTGGGCCGTCAGGCATGGGCCTGTGCAACACAGAGCCCGTTCCTCAGGCGAGTGGTGCT
GAGGTGCTCTGTGGTGATGGGAACGGCAGAGGCTGGCAGGTGACTGAACTTAGCCCAGGGCAGCTCCACATCCTGGGAACACTTTCATGT
AACCCCTTCTAGTTTTGAACTCTGCAGCAGGCTGGTGCTGTGTAGTGGCCACCCAGTCACCACCCTTGGAAGGGTGTCAGGGTCTGGGCT
CGCATGCACCCTGCTCCCTTCTGCCAGCCTGCATCCTCTCCTCAGGCCTCCTTCCCACATCATCTGTCTTCTCTAAGTTAGGGAACCATA
TTTGAGACTTTCAAAAAGGGAACTTCTAGGTTTAAGCTCCTCCCAGTAGATTCCTGAACCCAATTATCAGGAAATCATCCTGAGCACTCA
CAGGTTCATTTAACACTCACTCATCAAGCACCTTCCTATGTGCTAGGTGCTGGGGAAAACTTGACCAAGGAAGAGTTCCTGTCCTGAAGC
TTCCAGGACCCAGCTTTCCTTTTCTGGTGTGGCCTTGTAGCTAGTGCCTGGGCACAGGTGTTTTTCTTTTTGCAGTTTTACCTAGTGCTG
GGAGTTCAGTTCTTTTTCCTCTAGAAAAATACCTCTGTGCTCCAGAGCCTAATTTTTCCCAGATGCATATTTAGCTCTAGGGAGAGGACT
AGGAGGAAATCCCCCTCCCTTTAGCTGCCTGAACTGACTGAGGCCCACTCACTAGAGCCATGTTCAGTGCTACTGTGATTAGTAGTAATT

>In-frame_ENST00000314607_ENST00000397631_TCGA-06-5414-01A_ZMYM4_chr1_35791006_+_MANEAL_chr1_38261409_length(amino acids)=134AA_start in transcript=699_stop in transcript=295
MLLLFDEVLRPAACQLQVQAGLVRQVVQIQAGGCLLGNGLLNLGALVPLIEGGNGNDLGPHCQGRLQGRLIVLAIDPVARIVVVPGPNAG

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Fusion Gene PPI Analysis for ZMYM4-MANEAL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZMYM4-MANEAL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZMYM4-MANEAL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource