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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZMYND8-CEP250 (FusionGDB2 ID:100709)

Fusion Gene Summary for ZMYND8-CEP250

check button Fusion gene summary
Fusion gene informationFusion gene name: ZMYND8-CEP250
Fusion gene ID: 100709
HgeneTgene
Gene symbol

ZMYND8

CEP250

Gene ID

23613

11190

Gene namezinc finger MYND-type containing 8centrosomal protein 250
SynonymsPRKCBP1|PRO2893|RACK7C-NAP1|CEP2|CNAP1|CRDHL2
Cytomap

20q13.12

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C-binding protein 1CTCL tumor antigen se14-3cutaneous T-cell lymphoma-associated antigen se14-3predicted protein of HQ2893zinc finger MYND domain-containing protein 8centrosome-associated protein CEP250250 kDa centrosomal proteincentrosomal Nek2-associated protein 1
Modification date2020031320200313
UniProtAcc.

Q9BV73

Ensembl transtripts involved in fusion geneENST00000311275, ENST00000360911, 
ENST00000458360, ENST00000262975, 
ENST00000471951, ENST00000352431, 
ENST00000396281, ENST00000446994, 
ENST00000536340, ENST00000355972, 
ENST00000540497, ENST00000461685, 
ENST00000372023, ENST00000468376, 
ENST00000397527, ENST00000342580, 
ENST00000476146, ENST00000397524, 
Fusion gene scores* DoF score25 X 23 X 10=57508 X 9 X 6=432
# samples 349
** MAII scorelog2(34/5750*10)=-4.0799553045814
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZMYND8 [Title/Abstract] AND CEP250 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZMYND8(45852969)-CEP250(34078460), # samples:1
Anticipated loss of major functional domain due to fusion event.ZMYND8-CEP250 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ZMYND8-CEP250 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ZMYND8-CEP250 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCEP250

GO:0000278

mitotic cell cycle

12140259

TgeneCEP250

GO:0030997

regulation of centriole-centriole cohesion

9647649


check buttonFusion gene breakpoints across ZMYND8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CEP250 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AXX000006ZMYND8chr20

45852969

-CEP250chr20

34078460

+


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Fusion Gene ORF analysis for ZMYND8-CEP250

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000311275ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000311275ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000311275ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000311275ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+
Frame-shiftENST00000360911ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000360911ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000360911ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000360911ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+
Frame-shiftENST00000458360ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000458360ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000458360ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000458360ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+
In-frameENST00000262975ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000262975ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000262975ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000262975ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+
Frame-shiftENST00000471951ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000471951ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000471951ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000471951ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+
Frame-shiftENST00000352431ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000352431ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000352431ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000352431ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+
Frame-shiftENST00000396281ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000396281ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000396281ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000396281ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+
In-frameENST00000446994ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000446994ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000446994ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000446994ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+
Frame-shiftENST00000536340ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000536340ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000536340ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000536340ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+
In-frameENST00000355972ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000355972ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000355972ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000355972ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+
Frame-shiftENST00000540497ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000540497ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000540497ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000540497ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+
Frame-shiftENST00000461685ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000461685ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000461685ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000461685ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+
Frame-shiftENST00000372023ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000372023ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000372023ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
5CDS-intronENST00000372023ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+
intron-3CDSENST00000468376ENST00000397527ZMYND8chr20

45852969

-CEP250chr20

34078460

+
intron-intronENST00000468376ENST00000342580ZMYND8chr20

45852969

-CEP250chr20

34078460

+
intron-intronENST00000468376ENST00000476146ZMYND8chr20

45852969

-CEP250chr20

34078460

+
intron-intronENST00000468376ENST00000397524ZMYND8chr20

45852969

-CEP250chr20

34078460

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262975ZMYND8chr2045852969-ENST00000397527CEP250chr2034078460+84343342337280841570
ENST00000446994ZMYND8chr2045852969-ENST00000397527CEP250chr2034078460+80502958298877001570
ENST00000355972ZMYND8chr2045852969-ENST00000397527CEP250chr2034078460+84483356338680981570

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262975ENST00000397527ZMYND8chr2045852969-CEP250chr2034078460+0.0153981130.98460186
ENST00000446994ENST00000397527ZMYND8chr2045852969-CEP250chr2034078460+0.0196715540.9803285
ENST00000355972ENST00000397527ZMYND8chr2045852969-CEP250chr2034078460+0.0151188230.98488116

Top

Fusion Genomic Features for ZMYND8-CEP250


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZMYND8chr2045852969-CEP250chr2034078462+4.89E-111
ZMYND8chr2045852969-CEP250chr2034078462+4.89E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ZMYND8-CEP250


check button Go to

FGviewer for the breakpoints of chr20:45852969-chr20:34078460

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CEP250

Q9BV73

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May be involved in ciliogenesis (PubMed:28005958). Probably plays an important role in centrosome cohesion during interphase. {ECO:0000269|PubMed:28005958}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYND8chr20:45852969chr20:34078460ENST00000262975-202443_471019.33333333333341169.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45852969chr20:34078460ENST00000262975-2024838_8541019.33333333333341169.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45852969chr20:34078460ENST00000311275-192243_471065.33333333333331187.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45852969chr20:34078460ENST00000311275-1922838_8541065.33333333333331187.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45852969chr20:34078460ENST00000352431-192243_471039.33333333333331161.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45852969chr20:34078460ENST00000352431-1922838_8541039.33333333333331161.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45852969chr20:34078460ENST00000355972-202443_471065.33333333333331215.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45852969chr20:34078460ENST00000355972-2024838_8541065.33333333333331215.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45852969chr20:34078460ENST00000360911-192243_471014.33333333333341136.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45852969chr20:34078460ENST00000360911-1922838_8541014.33333333333341136.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45852969chr20:34078460ENST00000461685-192343_471039.33333333333331189.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45852969chr20:34078460ENST00000461685-1923838_8541039.33333333333331189.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45852969chr20:34078460ENST00000471951-192343_471085.33333333333331235.0Compositional biasNote=Poly-Lys
HgeneZMYND8chr20:45852969chr20:34078460ENST00000471951-1923838_8541085.33333333333331235.0Compositional biasNote=Poly-Gln
HgeneZMYND8chr20:45852969chr20:34078460ENST00000262975-2024165_2351019.33333333333341169.0DomainBromo
HgeneZMYND8chr20:45852969chr20:34078460ENST00000262975-2024277_3271019.33333333333341169.0DomainPWWP
HgeneZMYND8chr20:45852969chr20:34078460ENST00000311275-1922165_2351065.33333333333331187.0DomainBromo
HgeneZMYND8chr20:45852969chr20:34078460ENST00000311275-1922277_3271065.33333333333331187.0DomainPWWP
HgeneZMYND8chr20:45852969chr20:34078460ENST00000352431-1922165_2351039.33333333333331161.0DomainBromo
HgeneZMYND8chr20:45852969chr20:34078460ENST00000352431-1922277_3271039.33333333333331161.0DomainPWWP
HgeneZMYND8chr20:45852969chr20:34078460ENST00000355972-2024165_2351065.33333333333331215.0DomainBromo
HgeneZMYND8chr20:45852969chr20:34078460ENST00000355972-2024277_3271065.33333333333331215.0DomainPWWP
HgeneZMYND8chr20:45852969chr20:34078460ENST00000360911-1922165_2351014.33333333333341136.0DomainBromo
HgeneZMYND8chr20:45852969chr20:34078460ENST00000360911-1922277_3271014.33333333333341136.0DomainPWWP
HgeneZMYND8chr20:45852969chr20:34078460ENST00000461685-1923165_2351039.33333333333331189.0DomainBromo
HgeneZMYND8chr20:45852969chr20:34078460ENST00000461685-1923277_3271039.33333333333331189.0DomainPWWP
HgeneZMYND8chr20:45852969chr20:34078460ENST00000471951-1923165_2351085.33333333333331235.0DomainBromo
HgeneZMYND8chr20:45852969chr20:34078460ENST00000471951-1923277_3271085.33333333333331235.0DomainPWWP
HgeneZMYND8chr20:45852969chr20:34078460ENST00000262975-202488_1331019.33333333333341169.0Zinc fingerPHD-type
HgeneZMYND8chr20:45852969chr20:34078460ENST00000311275-19221028_10621065.33333333333331187.0Zinc fingerMYND-type
HgeneZMYND8chr20:45852969chr20:34078460ENST00000311275-192288_1331065.33333333333331187.0Zinc fingerPHD-type
HgeneZMYND8chr20:45852969chr20:34078460ENST00000352431-192288_1331039.33333333333331161.0Zinc fingerPHD-type
HgeneZMYND8chr20:45852969chr20:34078460ENST00000355972-20241028_10621065.33333333333331215.0Zinc fingerMYND-type
HgeneZMYND8chr20:45852969chr20:34078460ENST00000355972-202488_1331065.33333333333331215.0Zinc fingerPHD-type
HgeneZMYND8chr20:45852969chr20:34078460ENST00000360911-192288_1331014.33333333333341136.0Zinc fingerPHD-type
HgeneZMYND8chr20:45852969chr20:34078460ENST00000461685-192388_1331039.33333333333331189.0Zinc fingerPHD-type
HgeneZMYND8chr20:45852969chr20:34078460ENST00000471951-19231028_10621085.33333333333331235.0Zinc fingerMYND-type
HgeneZMYND8chr20:45852969chr20:34078460ENST00000471951-192388_1331085.33333333333331235.0Zinc fingerPHD-type
TgeneCEP250chr20:45852969chr20:34078460ENST000003425800341243_222702387.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr20:45852969chr20:34078460ENST000003425800342262_237602387.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr20:45852969chr20:34078460ENST00000342580034244_35202387.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr20:45852969chr20:34078460ENST00000342580034395_117202387.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr20:45852969chr20:34078460ENST0000034258003495_15802387.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr20:45852969chr20:34078460ENST0000039752719351243_2227862.02443.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr20:45852969chr20:34078460ENST0000039752719352262_2376862.02443.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr20:45852969chr20:34078460ENST00000342580034246_25002387.0Compositional biasNote=Poly-Leu
TgeneCEP250chr20:45852969chr20:34078460ENST00000342580034464_217102387.0Compositional biasNote=Gln/Glu-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZMYND8chr20:45852969chr20:34078460ENST00000262975-20241089_10921019.33333333333341169.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45852969chr20:34078460ENST00000311275-19221089_10921065.33333333333331187.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45852969chr20:34078460ENST00000352431-19221089_10921039.33333333333331161.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45852969chr20:34078460ENST00000355972-20241089_10921065.33333333333331215.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45852969chr20:34078460ENST00000360911-19221089_10921014.33333333333341136.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45852969chr20:34078460ENST00000461685-19231089_10921039.33333333333331189.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45852969chr20:34078460ENST00000471951-19231089_10921085.33333333333331235.0Compositional biasNote=Poly-Ser
HgeneZMYND8chr20:45852969chr20:34078460ENST00000262975-20241028_10621019.33333333333341169.0Zinc fingerMYND-type
HgeneZMYND8chr20:45852969chr20:34078460ENST00000352431-19221028_10621039.33333333333331161.0Zinc fingerMYND-type
HgeneZMYND8chr20:45852969chr20:34078460ENST00000360911-19221028_10621014.33333333333341136.0Zinc fingerMYND-type
HgeneZMYND8chr20:45852969chr20:34078460ENST00000461685-19231028_10621039.33333333333331189.0Zinc fingerMYND-type
TgeneCEP250chr20:45852969chr20:34078460ENST000003975271935244_352862.02443.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr20:45852969chr20:34078460ENST000003975271935395_1172862.02443.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr20:45852969chr20:34078460ENST00000397527193595_158862.02443.0Coiled coilOntology_term=ECO:0000255
TgeneCEP250chr20:45852969chr20:34078460ENST000003975271935246_250862.02443.0Compositional biasNote=Poly-Leu
TgeneCEP250chr20:45852969chr20:34078460ENST000003975271935464_2171862.02443.0Compositional biasNote=Gln/Glu-rich


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Fusion Gene Sequence for ZMYND8-CEP250


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000262975_ENST00000397527_XX000006_ZMYND8_chr20_45852969_-_CEP250_chr20_34078460_length(transcript)=8434nt_BP=3342nt
CGGCTTTACACTCCGATTTGCCGGGGCAGCCAATCGGGGATGAGCTTTTATTAGGCGGCCAGATCATCAGCCGAAGTGCCAAACCCTTTT
TCTGTGAGAACTAGGAGCCTGTCCTCCATGTTTTATAAGTATTGACATTACACAGTGTTAACAATGCATCCACAGAGTCCCAAATCTGCC
AGCCTGTTCTCTCTTCCTAACTGTGGAAAAATGAGACGGTTGCTTGAACATTTGTTGGCTTGGCTGAAGAGGAAATAAAAACAGAACAGG
AGGTGGTAGAGGGCATGGATATCTCTACTCGCTCCAAAGATCCTGGCTCTGCAGAGAGAACAGCCCAGAAAAGAAAGTTCCCCAGCCCTC
CACATTCTTCCAATGGCCACTCGCCGCAGGACACATCAACAAGCCCCATTAAAAAGAAAAAGAAACCTGGCTTACTGAACAGTAACAATA
AGGAGCAGTCAGAACTAAGACATGGTCCGTTTTACTATATGAAGCAGCCACTCACCACAGACCCTGTTGATGTTGTACCGCAGGATGGAC
GGAATGATTTCTACTGCTGGGTTTGTCACCGGGAAGGCCAAGTCCTTTGCTGTGAGCTCTGTCCCCGGGTTTATCACGCTAAGTGTCTGA
GACTGACATCGGAACCAGAGGGGGACTGGTTTTGTCCTGAATGTGAGAAAATTACAGTAGCAGAATGCATCGAGACCCAGAGTAAAGCCA
TGACAATGCTCACCATTGAACAGTTATCCTACCTGCTCAAGTTTGCCATTCAGAAAATGAAACAGCCAGGGACAGATGCATTCCAGAAGC
CCGTTCCATTGGAACAGCACCCTGACTATGCGGAATACATCTTCCATCCAATGGACCTTTGTACATTGGAAAAGAATGCGAAAAAGAAAA
TGTATGGCTGCACAGAAGCCTTCCTGGCTGATGCAAAGTGGATTTTGCACAACTGCATCATTTATAATGGGGGAAATCACAAATTGACGC
AAATAGCGAAAGTAGTCATCAAAATCTGTGAACATGAGATGAATGAAATCGAAGTATGTCCAGAATGTTATCTAGCTGCTTGCCAAAAAC
GAGATAACTGGTTTTGTGAGCCTTGTAGCAATCCACATCCTTTGGTCTGGGCCAAACTGAAGGGGTTTCCATTCTGGCCTGCAAAAGCTC
TAAGGGATAAAGACGGGCAGGTCGATGCCCGATTCTTTGGACAACATGACAGGGCCTGGGTTCCAATAAATAATTGCTACCTCATGTCTA
AAGAAATTCCTTTTTCTGTGAAAAAGACTAAGAGCATCTTCAACAGTGCCATGCAAGAGATGGAGGTTTACGTGGAGAACATCCGCAGGA
AGTTTGGGGTTTTTAATTACTCTCCATTTAGGACACCCTACACACCCAACAGCCAGTATCAAATGCTGCTCGATCCCACCAACCCCAGCG
CCGGCACTGCCAAGATAGACAAGCAGGAGAAGGTCAAGCTCAACTTTGACATGACGGCATCCCCCAAGATCCTGATGAGCAAGCCTGTGC
TGAGTGGGGGCACAGGCCGCCGGATTTCCTTGTCGGATATGCCGCGCTCCCCCATGAGCACAAACTCTTCTGTGCACACGGGCTCCGACG
TGGAGCAGGATGCTGAGAAGAAGGCCACGTCGAGCCACTTCAGTGCGAGCGAGGAGTCCATGGACTTCCTGGATAAGAGCACAGCTTCAC
CAGCCTCCACCAAGACGGGACAAGCAGGGAGTTTATCCGGCAGCCCAAAGCCCTTCTCTCCTCAACTGTCAGCTCCTATCACGACGAAAA
CGGACAAAACCTCCACCACCGGCAGCATCCTGAATCTTAACCTGGATCGAAGCAAAGCTGAGATGGATTTGAAGGAGCTGAGCGAGTCGG
TCCAGCAACAGTCCACCCCTGTTCCTCTCATCTCTCCCAAGCGCCAGATTCGTAGCAGGTTCCAGCTGAATCTTGACAAGACCATAGAGA
GTTGCAAAGCACAATTAGGCATAAATGAAATCTCGGAAGATGTCTATACGGCCGTAGAGCACAGCGATTCGGAGGATTCTGAGAAGTCAG
ATAGTAGCGATAGTGAGTATATCAGTGATGATGAGCAGAAGTCTAAGAACGAGCCAGAAGACACAGAGGACAAAGAAGGTTGTCAGATGG
ACAAAGAGCCATCTGCTGTTAAAAAAAAGCCCAAGCCTACAAACCCAGTGGAGATTAAAGAGGAGCTGAAAAGCACGTCACCAGCCAGCG
AGAAGGCAGACCCTGGAGCAGTCAAGGACAAGGCCAGCCCTGAGCCTGAGAAGGACTTTTCCGAAAAGGCAAAACCTTCACCTCACCCCA
TAAAGGATAAACTGAAGGGAAAAGATGAGACGGATTCCCCAACAGTCCATTTGGGCCTGGACTCTGATTCAGAGAGCGAACTTGTCATAG
ATTTAGGAGAAGACCATTCTGGGCGGGAGGGTCGAAAAAATAAGAAGGAACCCAAAGAACCATCTCCCAAACAGGATGTTGTAGGTAAAA
CTCCACCATCCACGACGGTGGGCAGCCATTCTCCCCCGGAAACACCGGTGCTCACCCGCTCTTCCGCCCAAACTTCCGCGGCTGGCGCCA
CAGCCACCACCAGCACGTCCTCCACGGTCACCGTCACGGCCCCGGCCCCCGCCGCCACAGGAAGCCCAGTGAAAAAGCAGAGGCCGCTTT
TACCGAAGGAGACTGCCCCGGCCGTGCAGCGGGTCGTGTGGAACTCATCAACTGTCCAGCAGAAGGAGATCACACAGAGCCCATCCACGT
CCACCATCACCCTGGTGACCAGCACACAGTCATCGCCCCTGGTCACCAGCTCGGGGTCCATGAGCACCCTTGTGTCCTCAGTCAACGCTG
ACCTGCCCATCGCCACTGCCTCAGCTGATGTCGCCGCTGATATTGCCAAGTACACTAGCAAAATGATGGATGCAATAAAAGGAACAATGA
CAGAAATATACAACGATCTTTCTAAAAACACTACTGGAAGCACAATAGCTGAGATTCGCAGGCTGAGGATCGAGATAGAGAAGCTCCAGT
GGCTGCACCAGCAAGAGCTCTCCGAAATGAAACACAACTTAGAGCTGACCATGGCGGAGATGCGGCAGAGCCTGGAGCAGGAGCGGGACC
GGCTCATCGCCGAGGTGAAGAAGCAGCTGGAGTTGGAGAAGCAGCAGGCGGTGGATGAGACCAAGAAGAAGCAGTGGTGCGCCAACTGCA
AGAAGGAGGCCATCTTTTACTGCTGTTGGAACACTAGCTACTGTGACTACCCCTGCCAGCAAGCCCACTGGCCTGAGCACATGAAGTCCT
GCACCCAGTCAGGAGAAGGAGCGCTCCTGGCACCAGCAGGAGCTGGCAAAGGCTCTGGAGAGCTTAGAAAGGGAAAAAATGGAGCTGGAA
ATGAGGCTAAAGGAGCAGCAGACAGAAATGGAGGCCATCCAGGCCCAGAGGGAAGAAGAACGGACCCAGGCAGAGAGTGCCCTATGCCAG
ATGCAGCTGGAAACAGAGAAGGAGAGAGTATCCCTCCTGGAGACACTGCTGCAGACGCAGAAGGAGCTAGCAGATGCCAGCCAACAACTG
GAACGACTGAGGCAGGACATGAAAGTCCAGAAATTAAAGGAGCAGGAGACCACTGGGATACTACAGACCCAGCTCCAGGAGGCTCAACGG
GAGCTGAAGGAGGCAGCCCGGCAGCACAGAGATGACCTTGCTGCCCTCCAAGAAGAGAGCAGCTCCCTGCTGCAGGATAAGATGGACCTG
CAGAAGCAGGTGGAGGACTTGAAGTCTCAGCTGGTGGCCCAGGATGACTCCCAGAGGCTGGTGGAGCAGGAGGTTCAGGAGAAGCTGAGA
GAGACCCAGGAGTATAACCGAATTCAGAAGGAGCTGGAGAGAGAGAAAGCCAGCCTGACTCTGTCACTGATGGAAAAGGAACAGAGACTC
CTTGTTTTACAAGAAGCTGACTCTATTCGACAACAAGAGCTGAGTGCCCTGCGCCAGGACATGCAGGAGGCCCAGGGAGAACAGAAAGAG
CTCAGTGCTCAGATGGAATTACTAAGGCAAGAGGTGAAGGAAAAGGAGGCTGACTTTCTGGCCCAGGAAGCACAGCTGCTGGAGGAGCTG
GAGGCGTCTCATATCACGGAGCAGCAGCTGCGAGCCTCCTTGTGGGCCCAGGAAGCCAAGGCAGCCCAACTACAGCTGCGACTGCGCAGC
ACAGAGAGCCAGCTAGAAGCGCTGGCCGCAGAGCAGCAGCCCGGGAACCAGGCCCAGGCCCAGGCCCAGCTGGCCAGCCTCTACTCTGCC
CTGCAGCAGGCCCTGGGGTCTGTTTGTGAGAGCAGGCCTGAGCTGAGTGGTGGGGGAGACTCTGCTCCTTCCGTCTGGGGCCTTGAGCCA
GACCAGAATGGAGCTAGGAGCCTCTTTAAGAGAGGGCCCCTGCTGACTGCTCTCTCCGCTGAGGCAGTAGCATCTGCCCTCCACAAGCTT
CATCAAGACCTGTGGAAGACTCAACAGACCCGGGATGTTCTGAGGGATCAGGTCCAGAAACTGGAAGAGCGTCTAACTGATACTGAGGCT
GAGAAGAGCCAGGTCCACACAGAGTTGCAGGATCTGCAGAGACAGCTCTCCCAGAATCAGGAAGAGAAATCCAAGTGGGAAGGAAAGCAG
AACTCCCTAGAATCTGAGCTGATGGAACTACATGAAACTATGGCATCCTTACAGAGTCGCCTGCGGAGAGCAGAGCTACAGCGAATGGAA
GCCCAGGGTGAGCGAGAGTTACTTCAGGCAGCCAAGGAGAACCTGACAGCCCAGGTGGAACACCTGCAAGCAGCTGTCGTAGAAGCCAGG
GCTCAGGCAAGTGCTGCTGGCATCCTGGAAGAAGACCTGAGAACGGCTCGCTCAGCACTGAAGCTGAAAAATGAGGAAGTAGAGAGTGAG
CGTGAGAGAGCCCAGGCTCTGCAAGAGCAGGGCGAACTGAAGGTGGCCCAAGGGAAGGCTCTGCAAGAGAATTTGGCCCTCCTGACCCAG
ACCCTAGCTGAAAGAGAAGAGGAGGTGGAGACTCTGCGGGGACAAATCCAGGAACTGGAGAAGCAACGGGAAATGCAGAAGGCTGCTTTG
GAATTGCTGTCTCTGGACCTGAAGAAGAGGAACCAAGAGGTAGATCTGCAGCAAGAACAGATTCAGGAGCTAGAGAAGTGTAGGTCTGTT
TTAGAGCATCTGCCCATGGCCGTCCAGGAGCGAGAGCAGAAGCTGACTGTGCAGAGGGAGCAGATCAGAGAGCTCGAGAAGGATCGGGAG
ACTCAGAGGAACGTCTTGGAGCATCAGCTTCTAGAACTTGAGAAGAAAGACCAAATGATTGAGTCCCAGAGAGGACAGGTTCAGGACCTG
AAAAAGCAGTTGGTTACTCTGGAATGCCTGGCCCTGGAACTGGAGGAAAACCATCACAAGATGGAGTGCCAGCAAAAACTGATCAAGGAG
CTGGAGGGCCAGAGGGAAACCCAGAGAGTGGCTTTGACCCACCTTACGCTGGACCTAGAAGAAAGGAGCCAGGAGCTGCAGGCACAAAGC
AGCCAGATCCATGACCTGGAGAGCCACAGCACCGTTCTGGCAAGAGAGCTGCAGGAGAGGGACCAGGAGGTGAAGTCTCAGCGAGAACAG
ATCGAGGAGCTGCAGAGGCAGAAAGAGCATCTGACTCAGGATCTCGAGAGGAGAGACCAGGAGCTGATGCTGCAGAAGGAGAGGATTCAG
GTTCTCGAGGATCAGAGGACCCGGCAGACCAAGATCCTGGAGGAGGACCTGGAACAGATCAAGCTGTCCTTGAGAGAGCGAGGCCGGGAG
CTGACCACTCAGAGGCAGCTGATGCAGGAACGGGCAGAGGAAGGGAAGGGCCCAAGTAAAGCACAGCGCGGGAGCCTAGAGCACATGAAG
CTGATCCTGCGTGATAAGGAGAAGGAGGTGGAATGTCAGCAGGAGCATATCCATGAACTCCAGGAGCTCAAAGACCAGCTGGAGCAGCAG
CTCCAGGGCCTGCACAGGAAGGTAGGTGAGACCAGCCTCCTCCTGTCCCAGCGAGAGCAGGAAATAGTGGTCCTGCAGCAGCAACTGCAG
GAAGCCAGGGAACAAGGGGAGCTGAAGGAGCAGTCACTTCAGAGTCAACTGGATGAGGCCCAGAGAGCCCTAGCCCAGAGGGACCAGGAA
CTGGAGGCTCTGCAGCAAGAACAGCAGCAGGCCCAGGGACAGGAGGAGAGGGTGAAGGAAAAGGCAGACGCCCTCCAGGGAGCTCTGGAG
CAAGCCCATATGACACTGAAGGAGCGTCATGGAGAGCTTCAGGACCACAAGGAACAGGCACGAAGGCTGGAGGAAGAGCTGGCAGTGGAG
GGACGGCGGGTCCAGGCCCTGGAGGAGGTGCTGGGAGACCTAAGGGCTGAGTCTCGGGAACAGGAGAAAGCTCTGTTGGCCCTCCAGCAG
CAGTGTGCTGAGCAGGCACAGGAGCATGAGGTGGAGACCAGGGCCCTGCAGGACAGCTGGCTGCAGGCCCAGGCAGTGCTCAAGGAACGG
GACCAGGAGCTGGAAGCTCTGCGGGCAGAAAGTCAGTCCTCCCGGCATCAGGAGGAGGCTGCCCGGGCCCGGGCTGAGGCTCTGCAGGAG
GCCCTTGGCAAGGCTCATGCTGCCCTGCAGGGGAAAGAGCAGCATCTCCTCGAGCAGGCAGAATTGAGCCGCAGTCTGGAGGCCAGCACT
GCAACCCTGCAAGCCTCCCTGGATGCCTGCCAGGCACACAGTCGGCAGCTGGAGGAGGCTCTGAGGATACAAGAAGGTGAGATCCAGGAC
CAGGATCTCCGATACCAGGAGGATGTGCAGCAGCTGCAGCAGGCACTTGCCCAGAGGGATGAAGAGCTGAGACATCAGCAGGAACGGGAG
CAGCTGCTGGAGAAGTCTCTGGCCCAGAGGGTCCAAGAGAATATGATCCAAGAGAAGCAGAATCTGGGGCAAGAGAGAGAAGAGGAGGAG
ATAAGGGGCCTTCATCAGAGTGTAAGGGAGCTACAGCTGACTCTAGCCCAAAAGGAACAGGAGATTCTGGAGCTGAGGGAGACCCAGCAA
AGGAACAACCTGGAAGCCTTACCCCACAGCCACAAAACCTCCCCAATGGAGGAACAATCTCTAAAACTTGATTCTTTAGAGCCCAGGCTG
CAGCGGGAGCTGGAGCGGCTACAGGCAGCCCTGAGACAGACAGAAGCCAGGGAGATTGAGTGGAGGGAGAAGGCCCAGGACTTGGCACTC
TCCCTAGCGCAGACCAAGGCCAGTGTCAGCAGTCTGCAGGAGGTAGCCATGTTCCTACAAGCCTCTGTCCTGGAGCGGGACTCAGAACAG
CAAAGGCTGCAGGATGAACTGGAGCTCACCAGACGGGCTCTGGAGAAGGAGCGGCTACACAGCCCAGGTGCAACCAGCACAGCAGAACTG
GGGTCCAGAGGGGAGCAGGGTGTGCAGCTGGGAGAGGTCTCAGGAGTGGAGGCTGAGCCTAGTCCTGATGGAATGGAGAAGCAGTCATGG
AGACAAAGGCTTGAACACCTGCAGCAAGCAGTGGCCCGGCTGGAGATTGACAGGAGCAGGCTGCAGCGCCACAATGTCCAGCTGCGGAGT
ACCTTGGAGCAGGTGGAGCGAGAACGGAGGAAGCTGAAGAGGGAGGCCATGCGTGCGGCCCAGGCAGGGTCCCTAGAGATCAGCAAGGCC
ACGGCTTCTTCACCCACACAGCAGGATGGGAGAGGACAGAAGAACTCAGATGCCAAGTGTGTGGCTGAACTGCAGAAAGAGGTGGTCCTG
CTGCAAGCTCAGCTGACTTTGGAGCGGAAGCAGAAGCAGGACTACATCACCCGCTCAGCACAGACCAGCCGTGAGCTAGCAGGCCTGCAC
CACAGCCTCTCACACTCACTTCTTGCCGTGGCCCAGGCCCCTGAGGCCACTGTCCTGGAGGCAGAGACCCGCAGGCTGGATGAGTCCCTG
ACTCAAAGTCTGACATCCCCAGGGCCAGTCCTGCTACACCCCAGCCCCAGCACTACCCAAGCCGCCTCCAGGTAGCAGCCACAGCCAGGA
GCACACAGACAGAAGACTGTGTCATGGGTCATGGCCCCTCCGCACACCTACAGGTTTGCCAAAGGAAAAGCCTGGCTCTGTTAGGCACCC
AGGAGCCCCAGGTCGGCGGGTGTTCCCAGGAAGAGGAAGTAAATCTGCAACCCTGGGGAGGACCCCAACTCACCTGGGAATGAGGCAAAT
TGCATTTGCTTGCTCCCTATGGAATCACCCAGAGGGGTGCCTTGCCCTGGCTGAGGGACATGTACTGCCTCTCATCTAGAATTTATTTTC

>In-frame_ENST00000262975_ENST00000397527_XX000006_ZMYND8_chr20_45852969_-_CEP250_chr20_34078460_length(amino acids)=1570AA_start in transcript=3372_stop in transcript=8084
MAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE
QETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELER
EKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL
WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPL
LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM
ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELK
VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQK
LTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTH
LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILE
EDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL
LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ
DHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSS
RHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQ
ALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTS
PMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRAL
EKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKR
EAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAP

--------------------------------------------------------------
>In-frame_ENST00000446994_ENST00000397527_XX000006_ZMYND8_chr20_45852969_-_CEP250_chr20_34078460_length(transcript)=8050nt_BP=2958nt
GTTAATTCTCAGGCTCTGTTGGGGGTGGTCAGAAATCTAATTTCTTGGCTGAAGAGGAAATAAAAACAGAACAGGAGGTGGTAGAGGGCA
TGGATATCTCTACTCGCTCCAAAGATCCTGGCTCTGCAGAGAGAACAGCCCAGAAAAGAAAGTTCCCCAGCCCTCCACATTCTTCCAATG
GCCACTCGCCGCAGGACACATCAACAAGCCCCATTAAAAAGAAAAAGAAACCTGGCTTACTGAACAGTAACAATAAGGAGCAGGATGGAC
GGAATGATTTCTACTGCTGGGTTTGTCACCGGGAAGGCCAAGTCCTTTGCTGTGAGCTCTGTCCCCGGGTTTATCACGCTAAGTGTCTGA
GACTGACATCGGAACCAGAGGGGGACTGGTTTTGTCCTGAATGTGAGACAGATGCATTCCAGAAGCCCGTTCCATTGGAACAGCACCCTG
ACTATGCGGAATACATCTTCCATCCAATGGACCTTTGTACATTGGAAAAGAATGCGAAAAAGAAAATGTATGGCTGCACAGAAGCCTTCC
TGGCTGATGCAAAGTGGATTTTGCACAACTGCATCATTTATAATGGGGGAAATCACAAATTGACGCAAATAGCGAAAGTAGTCATCAAAA
TCTGTGAACATGAGATGAATGAAATCGAAGTATGTCCAGAATGTTATCTAGCTGCTTGCCAAAAACGAGATAACTGGTTTTGTGAGCCTT
GTAGCAATCCACATCCTTTGGTCTGGGCCAAACTGAAGGGGTTTCCATTCTGGCCTGCAAAAGCTCTAAGGGATAAAGACGGGCAGGTCG
ATGCCCGATTCTTTGGACAACATGACAGGGCCTGGGTTCCAATAAATAATTGCTACCTCATGTCTAAAGAAATTCCTTTTTCTGTGAAAA
AGACTAAGAGCATCTTCAACAGTGCCATGCAAGAGATGGAGGTTTACGTGGAGAACATCCGCAGGAAGTTTGGGGTTTTTAATTACTCTC
CATTTAGGACACCCTACACACCCAACAGCCAGTATCAAATGCTGCTCGATCCCACCAACCCCAGCGCCGGCACTGCCAAGATAGACAAGC
AGGAGAAGGTCAAGCTCAACTTTGACATGACGGCATCCCCCAAGATCCTGATGAGCAAGCCTGTGCTGAGTGGGGGCACAGGCCGCCGGA
TTTCCTTGTCGGATATGCCGCGCTCCCCCATGAGCACAAACTCTTCTGTGCACACGGGCTCCGACGTGGAGCAGGATGCTGAGAAGAAGG
CCACGTCGAGCCACTTCAGTGCGAGCGAGGAGTCCATGGACTTCCTGGATAAGAGCACAGCTTCACCAGCCTCCACCAAGACGGGACAAG
CAGGGAGTTTATCCGGCAGCCCAAAGCCCTTCTCTCCTCAACTGTCAGCTCCTATCACGACGAAAACGGACAAAACCTCCACCACCGGCA
GCATCCTGAATCTTAACCTGGATCGAAGCAAAGCTGAGATGGATTTGAAGGAGCTGAGCGAGTCGGTCCAGCAACAGTCCACCCCTGTTC
CTCTCATCTCTCCCAAGCGCCAGATTCGTAGCAGGTTCCAGCTGAATCTTGACAAGACCATAGAGAGTTGCAAAGCACAATTAGGCATAA
ATGAAATCTCGGAAGATGTCTATACGGCCGTAGAGCACAGCGATTCGGAGGATTCTGAGAAGTCAGATAGTAGCGATAGTGAGTATATCA
GTGATGATGAGCAGAAGTCTAAGAACGAGCCAGAAGACACAGAGGACAAAGAAGGTTGTCAGATGGACAAAGAGCCATCTGCTGTTAAAA
AAAAGCCCAAGCCTACAAACCCAGTGGAGATTAAAGAGGAGCTGAAAAGCACGTCACCAGCCAGCGAGAAGGCAGACCCTGGAGCAGTCA
AGGACAAGGCCAGCCCTGAGCCTGAGAAGGACTTTTCCGAAAAGGCAAAACCTTCACCTCACCCCATAAAGGATAAACTGAAGGGAAAAG
ATGAGACGGATTCCCCAACAGTCCATTTGGGCCTGGACTCTGATTCAGAGAGCGAACTTGTCATAGATTTAGGAGAAGACCATTCTGGGC
GGGAGGGTCGAAAAAATAAGAAGGAACCCAAAGAACCATCTCCCAAACAGGATGTTGTAGGTAAAACTCCACCATCCACGACGGTGGGCA
GCCATTCTCCCCCGGAAACACCGGTGCTCACCCGCTCTTCCGCCCAAACTTCCGCGGCTGGCGCCACAGCCACCACCAGCACGTCCTCCA
CGGTCACCGTCACGGCCCCGGCCCCCGCCGCCACAGGAAGCCCAGTGAAAAAGCAGAGGCCGCTTTTACCGAAGGAGACTGCCCCGGCCG
TGCAGCGGGTCGTGTGGAACTCATCAACTGTCCAGCAGAAGGAGATCACACAGAGCCCATCCACGTCCACCATCACCCTGGTGACCAGCA
CACAGTCATCGCCCCTGGTCACCAGCTCGGGGTCCATGAGCACCCTTGTGTCCTCAGTCAACGCTGACCTGCCCATCGCCACTGCCTCAG
CTGATGTCGCCGCTGATATTGCCAAGTACACTAGCAAAATGATGGATGCAATAAAAGGAACAATGACAGAAATATACAACGATCTTTCTA
AAAACACTACTGGAAGCACAATAGCTGAGATTCGCAGGCTGAGGATCGAGATAGAGAAGCTCCAGTGGCTGCACCAGCAAGAGCTCTCCG
AAATGAAACACAACTTAGAGCTGACCATGGCGGAGATGCGGCAGAGCCTGGAGCAGGAGCGGGACCGGCTCATCGCCGAGGTGAAGAAGC
AGCTGGAGTTGGAGAAGCAGCAGGCGGTGGATGAGACCAAGAAGAAGCAGTGGTGCGCCAACTGCAAGAAGGAGGCCATCTTTTACTGCT
GTTGGAACACTAGCTACTGTGACTACCCCTGCCAGCAAGCCCACTGGCCTGAGCACATGAAGTCCTGCACCCAGTCAGGAGAAGGAGCGC
TCCTGGCACCAGCAGGAGCTGGCAAAGGCTCTGGAGAGCTTAGAAAGGGAAAAAATGGAGCTGGAAATGAGGCTAAAGGAGCAGCAGACA
GAAATGGAGGCCATCCAGGCCCAGAGGGAAGAAGAACGGACCCAGGCAGAGAGTGCCCTATGCCAGATGCAGCTGGAAACAGAGAAGGAG
AGAGTATCCCTCCTGGAGACACTGCTGCAGACGCAGAAGGAGCTAGCAGATGCCAGCCAACAACTGGAACGACTGAGGCAGGACATGAAA
GTCCAGAAATTAAAGGAGCAGGAGACCACTGGGATACTACAGACCCAGCTCCAGGAGGCTCAACGGGAGCTGAAGGAGGCAGCCCGGCAG
CACAGAGATGACCTTGCTGCCCTCCAAGAAGAGAGCAGCTCCCTGCTGCAGGATAAGATGGACCTGCAGAAGCAGGTGGAGGACTTGAAG
TCTCAGCTGGTGGCCCAGGATGACTCCCAGAGGCTGGTGGAGCAGGAGGTTCAGGAGAAGCTGAGAGAGACCCAGGAGTATAACCGAATT
CAGAAGGAGCTGGAGAGAGAGAAAGCCAGCCTGACTCTGTCACTGATGGAAAAGGAACAGAGACTCCTTGTTTTACAAGAAGCTGACTCT
ATTCGACAACAAGAGCTGAGTGCCCTGCGCCAGGACATGCAGGAGGCCCAGGGAGAACAGAAAGAGCTCAGTGCTCAGATGGAATTACTA
AGGCAAGAGGTGAAGGAAAAGGAGGCTGACTTTCTGGCCCAGGAAGCACAGCTGCTGGAGGAGCTGGAGGCGTCTCATATCACGGAGCAG
CAGCTGCGAGCCTCCTTGTGGGCCCAGGAAGCCAAGGCAGCCCAACTACAGCTGCGACTGCGCAGCACAGAGAGCCAGCTAGAAGCGCTG
GCCGCAGAGCAGCAGCCCGGGAACCAGGCCCAGGCCCAGGCCCAGCTGGCCAGCCTCTACTCTGCCCTGCAGCAGGCCCTGGGGTCTGTT
TGTGAGAGCAGGCCTGAGCTGAGTGGTGGGGGAGACTCTGCTCCTTCCGTCTGGGGCCTTGAGCCAGACCAGAATGGAGCTAGGAGCCTC
TTTAAGAGAGGGCCCCTGCTGACTGCTCTCTCCGCTGAGGCAGTAGCATCTGCCCTCCACAAGCTTCATCAAGACCTGTGGAAGACTCAA
CAGACCCGGGATGTTCTGAGGGATCAGGTCCAGAAACTGGAAGAGCGTCTAACTGATACTGAGGCTGAGAAGAGCCAGGTCCACACAGAG
TTGCAGGATCTGCAGAGACAGCTCTCCCAGAATCAGGAAGAGAAATCCAAGTGGGAAGGAAAGCAGAACTCCCTAGAATCTGAGCTGATG
GAACTACATGAAACTATGGCATCCTTACAGAGTCGCCTGCGGAGAGCAGAGCTACAGCGAATGGAAGCCCAGGGTGAGCGAGAGTTACTT
CAGGCAGCCAAGGAGAACCTGACAGCCCAGGTGGAACACCTGCAAGCAGCTGTCGTAGAAGCCAGGGCTCAGGCAAGTGCTGCTGGCATC
CTGGAAGAAGACCTGAGAACGGCTCGCTCAGCACTGAAGCTGAAAAATGAGGAAGTAGAGAGTGAGCGTGAGAGAGCCCAGGCTCTGCAA
GAGCAGGGCGAACTGAAGGTGGCCCAAGGGAAGGCTCTGCAAGAGAATTTGGCCCTCCTGACCCAGACCCTAGCTGAAAGAGAAGAGGAG
GTGGAGACTCTGCGGGGACAAATCCAGGAACTGGAGAAGCAACGGGAAATGCAGAAGGCTGCTTTGGAATTGCTGTCTCTGGACCTGAAG
AAGAGGAACCAAGAGGTAGATCTGCAGCAAGAACAGATTCAGGAGCTAGAGAAGTGTAGGTCTGTTTTAGAGCATCTGCCCATGGCCGTC
CAGGAGCGAGAGCAGAAGCTGACTGTGCAGAGGGAGCAGATCAGAGAGCTCGAGAAGGATCGGGAGACTCAGAGGAACGTCTTGGAGCAT
CAGCTTCTAGAACTTGAGAAGAAAGACCAAATGATTGAGTCCCAGAGAGGACAGGTTCAGGACCTGAAAAAGCAGTTGGTTACTCTGGAA
TGCCTGGCCCTGGAACTGGAGGAAAACCATCACAAGATGGAGTGCCAGCAAAAACTGATCAAGGAGCTGGAGGGCCAGAGGGAAACCCAG
AGAGTGGCTTTGACCCACCTTACGCTGGACCTAGAAGAAAGGAGCCAGGAGCTGCAGGCACAAAGCAGCCAGATCCATGACCTGGAGAGC
CACAGCACCGTTCTGGCAAGAGAGCTGCAGGAGAGGGACCAGGAGGTGAAGTCTCAGCGAGAACAGATCGAGGAGCTGCAGAGGCAGAAA
GAGCATCTGACTCAGGATCTCGAGAGGAGAGACCAGGAGCTGATGCTGCAGAAGGAGAGGATTCAGGTTCTCGAGGATCAGAGGACCCGG
CAGACCAAGATCCTGGAGGAGGACCTGGAACAGATCAAGCTGTCCTTGAGAGAGCGAGGCCGGGAGCTGACCACTCAGAGGCAGCTGATG
CAGGAACGGGCAGAGGAAGGGAAGGGCCCAAGTAAAGCACAGCGCGGGAGCCTAGAGCACATGAAGCTGATCCTGCGTGATAAGGAGAAG
GAGGTGGAATGTCAGCAGGAGCATATCCATGAACTCCAGGAGCTCAAAGACCAGCTGGAGCAGCAGCTCCAGGGCCTGCACAGGAAGGTA
GGTGAGACCAGCCTCCTCCTGTCCCAGCGAGAGCAGGAAATAGTGGTCCTGCAGCAGCAACTGCAGGAAGCCAGGGAACAAGGGGAGCTG
AAGGAGCAGTCACTTCAGAGTCAACTGGATGAGGCCCAGAGAGCCCTAGCCCAGAGGGACCAGGAACTGGAGGCTCTGCAGCAAGAACAG
CAGCAGGCCCAGGGACAGGAGGAGAGGGTGAAGGAAAAGGCAGACGCCCTCCAGGGAGCTCTGGAGCAAGCCCATATGACACTGAAGGAG
CGTCATGGAGAGCTTCAGGACCACAAGGAACAGGCACGAAGGCTGGAGGAAGAGCTGGCAGTGGAGGGACGGCGGGTCCAGGCCCTGGAG
GAGGTGCTGGGAGACCTAAGGGCTGAGTCTCGGGAACAGGAGAAAGCTCTGTTGGCCCTCCAGCAGCAGTGTGCTGAGCAGGCACAGGAG
CATGAGGTGGAGACCAGGGCCCTGCAGGACAGCTGGCTGCAGGCCCAGGCAGTGCTCAAGGAACGGGACCAGGAGCTGGAAGCTCTGCGG
GCAGAAAGTCAGTCCTCCCGGCATCAGGAGGAGGCTGCCCGGGCCCGGGCTGAGGCTCTGCAGGAGGCCCTTGGCAAGGCTCATGCTGCC
CTGCAGGGGAAAGAGCAGCATCTCCTCGAGCAGGCAGAATTGAGCCGCAGTCTGGAGGCCAGCACTGCAACCCTGCAAGCCTCCCTGGAT
GCCTGCCAGGCACACAGTCGGCAGCTGGAGGAGGCTCTGAGGATACAAGAAGGTGAGATCCAGGACCAGGATCTCCGATACCAGGAGGAT
GTGCAGCAGCTGCAGCAGGCACTTGCCCAGAGGGATGAAGAGCTGAGACATCAGCAGGAACGGGAGCAGCTGCTGGAGAAGTCTCTGGCC
CAGAGGGTCCAAGAGAATATGATCCAAGAGAAGCAGAATCTGGGGCAAGAGAGAGAAGAGGAGGAGATAAGGGGCCTTCATCAGAGTGTA
AGGGAGCTACAGCTGACTCTAGCCCAAAAGGAACAGGAGATTCTGGAGCTGAGGGAGACCCAGCAAAGGAACAACCTGGAAGCCTTACCC
CACAGCCACAAAACCTCCCCAATGGAGGAACAATCTCTAAAACTTGATTCTTTAGAGCCCAGGCTGCAGCGGGAGCTGGAGCGGCTACAG
GCAGCCCTGAGACAGACAGAAGCCAGGGAGATTGAGTGGAGGGAGAAGGCCCAGGACTTGGCACTCTCCCTAGCGCAGACCAAGGCCAGT
GTCAGCAGTCTGCAGGAGGTAGCCATGTTCCTACAAGCCTCTGTCCTGGAGCGGGACTCAGAACAGCAAAGGCTGCAGGATGAACTGGAG
CTCACCAGACGGGCTCTGGAGAAGGAGCGGCTACACAGCCCAGGTGCAACCAGCACAGCAGAACTGGGGTCCAGAGGGGAGCAGGGTGTG
CAGCTGGGAGAGGTCTCAGGAGTGGAGGCTGAGCCTAGTCCTGATGGAATGGAGAAGCAGTCATGGAGACAAAGGCTTGAACACCTGCAG
CAAGCAGTGGCCCGGCTGGAGATTGACAGGAGCAGGCTGCAGCGCCACAATGTCCAGCTGCGGAGTACCTTGGAGCAGGTGGAGCGAGAA
CGGAGGAAGCTGAAGAGGGAGGCCATGCGTGCGGCCCAGGCAGGGTCCCTAGAGATCAGCAAGGCCACGGCTTCTTCACCCACACAGCAG
GATGGGAGAGGACAGAAGAACTCAGATGCCAAGTGTGTGGCTGAACTGCAGAAAGAGGTGGTCCTGCTGCAAGCTCAGCTGACTTTGGAG
CGGAAGCAGAAGCAGGACTACATCACCCGCTCAGCACAGACCAGCCGTGAGCTAGCAGGCCTGCACCACAGCCTCTCACACTCACTTCTT
GCCGTGGCCCAGGCCCCTGAGGCCACTGTCCTGGAGGCAGAGACCCGCAGGCTGGATGAGTCCCTGACTCAAAGTCTGACATCCCCAGGG
CCAGTCCTGCTACACCCCAGCCCCAGCACTACCCAAGCCGCCTCCAGGTAGCAGCCACAGCCAGGAGCACACAGACAGAAGACTGTGTCA
TGGGTCATGGCCCCTCCGCACACCTACAGGTTTGCCAAAGGAAAAGCCTGGCTCTGTTAGGCACCCAGGAGCCCCAGGTCGGCGGGTGTT
CCCAGGAAGAGGAAGTAAATCTGCAACCCTGGGGAGGACCCCAACTCACCTGGGAATGAGGCAAATTGCATTTGCTTGCTCCCTATGGAA
TCACCCAGAGGGGTGCCTTGCCCTGGCTGAGGGACATGTACTGCCTCTCATCTAGAATTTATTTTCCTAGCACTTCACCACCTCCTTCAT

>In-frame_ENST00000446994_ENST00000397527_XX000006_ZMYND8_chr20_45852969_-_CEP250_chr20_34078460_length(amino acids)=1570AA_start in transcript=2988_stop in transcript=7700
MAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE
QETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELER
EKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL
WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPL
LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM
ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELK
VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQK
LTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTH
LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILE
EDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL
LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ
DHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSS
RHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQ
ALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTS
PMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRAL
EKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKR
EAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAP

--------------------------------------------------------------
>In-frame_ENST00000355972_ENST00000397527_XX000006_ZMYND8_chr20_45852969_-_CEP250_chr20_34078460_length(transcript)=8448nt_BP=3356nt
ATAAGTATTGACATTACACAGTGTTAACAATGCATCCACAGAGTCCCAAATCTGCCAGCCTGTTCTCTCTTCCTAACTGTGGAAAAATGA
GACGGTTGCTTGAACATTTGTTGGCTTGGCTGAAGAGGAAATAAAAACAGAACAGGAGGTGGTAGAGGGCATGGATATCTCTACTCGCTC
CAAAGATCCTGGCTCTGCAGAGAGAACAGCCCAGAAAAGAAAGTTCCCCAGCCCTCCACATTCTTCCAATGGCCACTCGCCGCAGGACAC
ATCAACAAGCCCCATTAAAAAGAAAAAGAAACCTGGCTTACTGAACAGTAACAATAAGGAGCAGTCAGAACTAAGACATGGTCCGTTTTA
CTATATGAAGCAGCCACTCACCACAGACCCTGTTGATGTTGTACCGCAGGATGGACGGAATGATTTCTACTGCTGGGTTTGTCACCGGGA
AGGCCAAGTCCTTTGCTGTGAGCTCTGTCCCCGGGTTTATCACGCTAAGTGTCTGAGACTGACATCGGAACCAGAGGGGGACTGGTTTTG
TCCTGAATGTGAGAAAATTACAGTAGCAGAATGCATCGAGACCCAGAGTAAAGCCATGACAATGCTCACCATTGAACAGTTATCCTACCT
GCTCAAGTTTGCCATTCAGAAAATGAAACAGCCAGGGACAGATGCATTCCAGAAGCCCGTTCCATTGGAACAGCACCCTGACTATGCGGA
ATACATCTTCCATCCAATGGACCTTTGTACATTGGAAAAGAATGCGAAAAAGAAAATGTATGGCTGCACAGAAGCCTTCCTGGCTGATGC
AAAGTGGATTTTGCACAACTGCATCATTTATAATGGGGGAAATCACAAATTGACGCAAATAGCGAAAGTAGTCATCAAAATCTGTGAACA
TGAGATGAATGAAATCGAAGTATGTCCAGAATGTTATCTAGCTGCTTGCCAAAAACGAGATAACTGGTTTTGTGAGCCTTGTAGCAATCC
ACATCCTTTGGTCTGGGCCAAACTGAAGGGGTTTCCATTCTGGCCTGCAAAAGCTCTAAGGGATAAAGACGGGCAGGTCGATGCCCGATT
CTTTGGACAACATGACAGGGCCTGGGTTCCAATAAATAATTGCTACCTCATGTCTAAAGAAATTCCTTTTTCTGTGAAAAAGACTAAGAG
CATCTTCAACAGTGCCATGCAAGAGATGGAGGTTTACGTGGAGAACATCCGCAGGAAGTTTGGGGTTTTTAATTACTCTCCATTTAGGAC
ACCCTACACACCCAACAGCCAGTATCAAATGCTGCTCGATCCCACCAACCCCAGCGCCGGCACTGCCAAGATAGACAAGCAGGAGAAGGT
CAAGCTCAACTTTGACATGACGGCATCCCCCAAGATCCTGATGAGCAAGCCTGTGCTGAGTGGGGGCACAGGCCGCCGGATTTCCTTGTC
GGATATGCCGCGCTCCCCCATGAGCACAAACTCTTCTGTGCACACGGGCTCCGACGTGGAGCAGGATGCTGAGAAGAAGGCCACGTCGAG
CCACTTCAGTGCGAGCGAGGAGTCCATGGACTTCCTGGATAAGAGCACAGCTTCACCAGCCTCCACCAAGACGGGACAAGCAGGGAGTTT
ATCCGGCAGCCCAAAGCCCTTCTCTCCTCAACTGTCAGCTCCTATCACGACGAAAACGGACAAAACCTCCACCACCGGCAGCATCCTGAA
TCTTAACCTGGATCGAAGCAAAGCTGAGATGGATTTGAAGGAGCTGAGCGAGTCGGTCCAGCAACAGTCCACCCCTGTTCCTCTCATCTC
TCCCAAGCGCCAGATTCGTAGCAGGTTCCAGCTGAATCTTGACAAGACCATAGAGAGTTGCAAAGCACAATTAGGCATAAATGAAATCTC
GGAAGATGTCTATACGGCCGTAGAGCACAGCGATTCGGAGGATTCTGAGAAGTCAGATAGTAGCGATAGTGAGTATATCAGTGATGATGA
GCAGAAGTCTAAGAACGAGCCAGAAGACACAGAGGACAAAGAAGGTTGTCAGATGGACAAAGAGCCATCTGCTGTTAAAAAAAAGCCCAA
GCCTACAAACCCAGTGGAGATTAAAGAGGAGCTGAAAAGCACGTCACCAGCCAGCGAGAAGGCAGACCCTGGAGCAGTCAAGGACAAGGC
CAGCCCTGAGCCTGAGAAGGACTTTTCCGAAAAGGCAAAACCTTCACCTCACCCCATAAAGGATAAACTGAAGGGAAAAGATGAGACGGA
TTCCCCAACAGTCCATTTGGGCCTGGACTCTGATTCAGAGAGCGAACTTGTCATAGATTTAGGAGAAGACCATTCTGGGCGGGAGGGTCG
AAAAAATAAGAAGGAACCCAAAGAACCATCTCCCAAACAGGATGTTGTAGGTAAAACTCCACCATCCACGACGGTGGGCAGCCATTCTCC
CCCGGAAACACCGGTGCTCACCCGCTCTTCCGCCCAAACTTCCGCGGCTGGCGCCACAGCCACCACCAGCACGTCCTCCACGGTCACCGT
CACGGCCCCGGCCCCCGCCGCCACAGGAAGCCCAGTGAAAAAGCAGAGGCCGCTTTTACCGAAGGAGACTGCCCCGGCCGTGCAGCGGGT
CGTGTGGAACTCATCAAGTAAGTTTCAAACGTCCTCCCAAAAGTGGCACATGCAGAAGATGCAGCGTCAGCAGCAGCAGCAGCAGCAGCA
AAACCAGCAGCAGCAGCCTCAGTCTTCCCAGGGGACGAGATATCAGACCAGACAGGCTGTGAAAGCTGTCCAGCAGAAGGAGATCACACA
GAGCCCATCCACGTCCACCATCACCCTGGTGACCAGCACACAGTCATCGCCCCTGGTCACCAGCTCGGGGTCCATGAGCACCCTTGTGTC
CTCAGTCAACGCTGACCTGCCCATCGCCACTGCCTCAGCTGATGTCGCCGCTGATATTGCCAAGTACACTAGCAAAATGATGGATGCAAT
AAAAGGAACAATGACAGAAATATACAACGATCTTTCTAAAAACACTACTGGAAGCACAATAGCTGAGATTCGCAGGCTGAGGATCGAGAT
AGAGAAGCTCCAGTGGCTGCACCAGCAAGAGCTCTCCGAAATGAAACACAACTTAGAGCTGACCATGGCGGAGATGCGGCAGAGCCTGGA
GCAGGAGCGGGACCGGCTCATCGCCGAGGTGAAGAAGCAGCTGGAGTTGGAGAAGCAGCAGGCGGTGGATGAGACCAAGAAGAAGCAGTG
GTGCGCCAACTGCAAGAAGGAGGCCATCTTTTACTGCTGTTGGAACACTAGCTACTGTGACTACCCCTGCCAGCAAGCCCACTGGCCTGA
GCACATGAAGTCCTGCACCCAGTCAGGAGAAGGAGCGCTCCTGGCACCAGCAGGAGCTGGCAAAGGCTCTGGAGAGCTTAGAAAGGGAAA
AAATGGAGCTGGAAATGAGGCTAAAGGAGCAGCAGACAGAAATGGAGGCCATCCAGGCCCAGAGGGAAGAAGAACGGACCCAGGCAGAGA
GTGCCCTATGCCAGATGCAGCTGGAAACAGAGAAGGAGAGAGTATCCCTCCTGGAGACACTGCTGCAGACGCAGAAGGAGCTAGCAGATG
CCAGCCAACAACTGGAACGACTGAGGCAGGACATGAAAGTCCAGAAATTAAAGGAGCAGGAGACCACTGGGATACTACAGACCCAGCTCC
AGGAGGCTCAACGGGAGCTGAAGGAGGCAGCCCGGCAGCACAGAGATGACCTTGCTGCCCTCCAAGAAGAGAGCAGCTCCCTGCTGCAGG
ATAAGATGGACCTGCAGAAGCAGGTGGAGGACTTGAAGTCTCAGCTGGTGGCCCAGGATGACTCCCAGAGGCTGGTGGAGCAGGAGGTTC
AGGAGAAGCTGAGAGAGACCCAGGAGTATAACCGAATTCAGAAGGAGCTGGAGAGAGAGAAAGCCAGCCTGACTCTGTCACTGATGGAAA
AGGAACAGAGACTCCTTGTTTTACAAGAAGCTGACTCTATTCGACAACAAGAGCTGAGTGCCCTGCGCCAGGACATGCAGGAGGCCCAGG
GAGAACAGAAAGAGCTCAGTGCTCAGATGGAATTACTAAGGCAAGAGGTGAAGGAAAAGGAGGCTGACTTTCTGGCCCAGGAAGCACAGC
TGCTGGAGGAGCTGGAGGCGTCTCATATCACGGAGCAGCAGCTGCGAGCCTCCTTGTGGGCCCAGGAAGCCAAGGCAGCCCAACTACAGC
TGCGACTGCGCAGCACAGAGAGCCAGCTAGAAGCGCTGGCCGCAGAGCAGCAGCCCGGGAACCAGGCCCAGGCCCAGGCCCAGCTGGCCA
GCCTCTACTCTGCCCTGCAGCAGGCCCTGGGGTCTGTTTGTGAGAGCAGGCCTGAGCTGAGTGGTGGGGGAGACTCTGCTCCTTCCGTCT
GGGGCCTTGAGCCAGACCAGAATGGAGCTAGGAGCCTCTTTAAGAGAGGGCCCCTGCTGACTGCTCTCTCCGCTGAGGCAGTAGCATCTG
CCCTCCACAAGCTTCATCAAGACCTGTGGAAGACTCAACAGACCCGGGATGTTCTGAGGGATCAGGTCCAGAAACTGGAAGAGCGTCTAA
CTGATACTGAGGCTGAGAAGAGCCAGGTCCACACAGAGTTGCAGGATCTGCAGAGACAGCTCTCCCAGAATCAGGAAGAGAAATCCAAGT
GGGAAGGAAAGCAGAACTCCCTAGAATCTGAGCTGATGGAACTACATGAAACTATGGCATCCTTACAGAGTCGCCTGCGGAGAGCAGAGC
TACAGCGAATGGAAGCCCAGGGTGAGCGAGAGTTACTTCAGGCAGCCAAGGAGAACCTGACAGCCCAGGTGGAACACCTGCAAGCAGCTG
TCGTAGAAGCCAGGGCTCAGGCAAGTGCTGCTGGCATCCTGGAAGAAGACCTGAGAACGGCTCGCTCAGCACTGAAGCTGAAAAATGAGG
AAGTAGAGAGTGAGCGTGAGAGAGCCCAGGCTCTGCAAGAGCAGGGCGAACTGAAGGTGGCCCAAGGGAAGGCTCTGCAAGAGAATTTGG
CCCTCCTGACCCAGACCCTAGCTGAAAGAGAAGAGGAGGTGGAGACTCTGCGGGGACAAATCCAGGAACTGGAGAAGCAACGGGAAATGC
AGAAGGCTGCTTTGGAATTGCTGTCTCTGGACCTGAAGAAGAGGAACCAAGAGGTAGATCTGCAGCAAGAACAGATTCAGGAGCTAGAGA
AGTGTAGGTCTGTTTTAGAGCATCTGCCCATGGCCGTCCAGGAGCGAGAGCAGAAGCTGACTGTGCAGAGGGAGCAGATCAGAGAGCTCG
AGAAGGATCGGGAGACTCAGAGGAACGTCTTGGAGCATCAGCTTCTAGAACTTGAGAAGAAAGACCAAATGATTGAGTCCCAGAGAGGAC
AGGTTCAGGACCTGAAAAAGCAGTTGGTTACTCTGGAATGCCTGGCCCTGGAACTGGAGGAAAACCATCACAAGATGGAGTGCCAGCAAA
AACTGATCAAGGAGCTGGAGGGCCAGAGGGAAACCCAGAGAGTGGCTTTGACCCACCTTACGCTGGACCTAGAAGAAAGGAGCCAGGAGC
TGCAGGCACAAAGCAGCCAGATCCATGACCTGGAGAGCCACAGCACCGTTCTGGCAAGAGAGCTGCAGGAGAGGGACCAGGAGGTGAAGT
CTCAGCGAGAACAGATCGAGGAGCTGCAGAGGCAGAAAGAGCATCTGACTCAGGATCTCGAGAGGAGAGACCAGGAGCTGATGCTGCAGA
AGGAGAGGATTCAGGTTCTCGAGGATCAGAGGACCCGGCAGACCAAGATCCTGGAGGAGGACCTGGAACAGATCAAGCTGTCCTTGAGAG
AGCGAGGCCGGGAGCTGACCACTCAGAGGCAGCTGATGCAGGAACGGGCAGAGGAAGGGAAGGGCCCAAGTAAAGCACAGCGCGGGAGCC
TAGAGCACATGAAGCTGATCCTGCGTGATAAGGAGAAGGAGGTGGAATGTCAGCAGGAGCATATCCATGAACTCCAGGAGCTCAAAGACC
AGCTGGAGCAGCAGCTCCAGGGCCTGCACAGGAAGGTAGGTGAGACCAGCCTCCTCCTGTCCCAGCGAGAGCAGGAAATAGTGGTCCTGC
AGCAGCAACTGCAGGAAGCCAGGGAACAAGGGGAGCTGAAGGAGCAGTCACTTCAGAGTCAACTGGATGAGGCCCAGAGAGCCCTAGCCC
AGAGGGACCAGGAACTGGAGGCTCTGCAGCAAGAACAGCAGCAGGCCCAGGGACAGGAGGAGAGGGTGAAGGAAAAGGCAGACGCCCTCC
AGGGAGCTCTGGAGCAAGCCCATATGACACTGAAGGAGCGTCATGGAGAGCTTCAGGACCACAAGGAACAGGCACGAAGGCTGGAGGAAG
AGCTGGCAGTGGAGGGACGGCGGGTCCAGGCCCTGGAGGAGGTGCTGGGAGACCTAAGGGCTGAGTCTCGGGAACAGGAGAAAGCTCTGT
TGGCCCTCCAGCAGCAGTGTGCTGAGCAGGCACAGGAGCATGAGGTGGAGACCAGGGCCCTGCAGGACAGCTGGCTGCAGGCCCAGGCAG
TGCTCAAGGAACGGGACCAGGAGCTGGAAGCTCTGCGGGCAGAAAGTCAGTCCTCCCGGCATCAGGAGGAGGCTGCCCGGGCCCGGGCTG
AGGCTCTGCAGGAGGCCCTTGGCAAGGCTCATGCTGCCCTGCAGGGGAAAGAGCAGCATCTCCTCGAGCAGGCAGAATTGAGCCGCAGTC
TGGAGGCCAGCACTGCAACCCTGCAAGCCTCCCTGGATGCCTGCCAGGCACACAGTCGGCAGCTGGAGGAGGCTCTGAGGATACAAGAAG
GTGAGATCCAGGACCAGGATCTCCGATACCAGGAGGATGTGCAGCAGCTGCAGCAGGCACTTGCCCAGAGGGATGAAGAGCTGAGACATC
AGCAGGAACGGGAGCAGCTGCTGGAGAAGTCTCTGGCCCAGAGGGTCCAAGAGAATATGATCCAAGAGAAGCAGAATCTGGGGCAAGAGA
GAGAAGAGGAGGAGATAAGGGGCCTTCATCAGAGTGTAAGGGAGCTACAGCTGACTCTAGCCCAAAAGGAACAGGAGATTCTGGAGCTGA
GGGAGACCCAGCAAAGGAACAACCTGGAAGCCTTACCCCACAGCCACAAAACCTCCCCAATGGAGGAACAATCTCTAAAACTTGATTCTT
TAGAGCCCAGGCTGCAGCGGGAGCTGGAGCGGCTACAGGCAGCCCTGAGACAGACAGAAGCCAGGGAGATTGAGTGGAGGGAGAAGGCCC
AGGACTTGGCACTCTCCCTAGCGCAGACCAAGGCCAGTGTCAGCAGTCTGCAGGAGGTAGCCATGTTCCTACAAGCCTCTGTCCTGGAGC
GGGACTCAGAACAGCAAAGGCTGCAGGATGAACTGGAGCTCACCAGACGGGCTCTGGAGAAGGAGCGGCTACACAGCCCAGGTGCAACCA
GCACAGCAGAACTGGGGTCCAGAGGGGAGCAGGGTGTGCAGCTGGGAGAGGTCTCAGGAGTGGAGGCTGAGCCTAGTCCTGATGGAATGG
AGAAGCAGTCATGGAGACAAAGGCTTGAACACCTGCAGCAAGCAGTGGCCCGGCTGGAGATTGACAGGAGCAGGCTGCAGCGCCACAATG
TCCAGCTGCGGAGTACCTTGGAGCAGGTGGAGCGAGAACGGAGGAAGCTGAAGAGGGAGGCCATGCGTGCGGCCCAGGCAGGGTCCCTAG
AGATCAGCAAGGCCACGGCTTCTTCACCCACACAGCAGGATGGGAGAGGACAGAAGAACTCAGATGCCAAGTGTGTGGCTGAACTGCAGA
AAGAGGTGGTCCTGCTGCAAGCTCAGCTGACTTTGGAGCGGAAGCAGAAGCAGGACTACATCACCCGCTCAGCACAGACCAGCCGTGAGC
TAGCAGGCCTGCACCACAGCCTCTCACACTCACTTCTTGCCGTGGCCCAGGCCCCTGAGGCCACTGTCCTGGAGGCAGAGACCCGCAGGC
TGGATGAGTCCCTGACTCAAAGTCTGACATCCCCAGGGCCAGTCCTGCTACACCCCAGCCCCAGCACTACCCAAGCCGCCTCCAGGTAGC
AGCCACAGCCAGGAGCACACAGACAGAAGACTGTGTCATGGGTCATGGCCCCTCCGCACACCTACAGGTTTGCCAAAGGAAAAGCCTGGC
TCTGTTAGGCACCCAGGAGCCCCAGGTCGGCGGGTGTTCCCAGGAAGAGGAAGTAAATCTGCAACCCTGGGGAGGACCCCAACTCACCTG
GGAATGAGGCAAATTGCATTTGCTTGCTCCCTATGGAATCACCCAGAGGGGTGCCTTGCCCTGGCTGAGGGACATGTACTGCCTCTCATC

>In-frame_ENST00000355972_ENST00000397527_XX000006_ZMYND8_chr20_45852969_-_CEP250_chr20_34078460_length(amino acids)=1570AA_start in transcript=3386_stop in transcript=8098
MAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE
QETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELER
EKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASL
WAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPL
LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM
ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELK
VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQK
LTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTH
LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILE
EDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLL
LSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ
DHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSS
RHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQ
ALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTS
PMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRAL
EKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKR
EAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZMYND8-CEP250


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneZMYND8chr20:45852969chr20:34078460ENST00000262975-202475_4061019.33333333333341169.0histone H3K14ac
HgeneZMYND8chr20:45852969chr20:34078460ENST00000311275-192275_4061065.33333333333331187.0histone H3K14ac
HgeneZMYND8chr20:45852969chr20:34078460ENST00000352431-192275_4061039.33333333333331161.0histone H3K14ac
HgeneZMYND8chr20:45852969chr20:34078460ENST00000355972-202475_4061065.33333333333331215.0histone H3K14ac
HgeneZMYND8chr20:45852969chr20:34078460ENST00000360911-192275_4061014.33333333333341136.0histone H3K14ac
HgeneZMYND8chr20:45852969chr20:34078460ENST00000461685-192375_4061039.33333333333331189.0histone H3K14ac
HgeneZMYND8chr20:45852969chr20:34078460ENST00000471951-192375_4061085.33333333333331235.0histone H3K14ac
HgeneZMYND8chr20:45852969chr20:34078460ENST00000262975-202475_2681019.33333333333341169.0histone H3K4me0
HgeneZMYND8chr20:45852969chr20:34078460ENST00000311275-192275_2681065.33333333333331187.0histone H3K4me0
HgeneZMYND8chr20:45852969chr20:34078460ENST00000352431-192275_2681039.33333333333331161.0histone H3K4me0
HgeneZMYND8chr20:45852969chr20:34078460ENST00000355972-202475_2681065.33333333333331215.0histone H3K4me0
HgeneZMYND8chr20:45852969chr20:34078460ENST00000360911-192275_2681014.33333333333341136.0histone H3K4me0
HgeneZMYND8chr20:45852969chr20:34078460ENST00000461685-192375_2681039.33333333333331189.0histone H3K4me0
HgeneZMYND8chr20:45852969chr20:34078460ENST00000471951-192375_2681085.33333333333331235.0histone H3K4me0


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneZMYND8chr20:45852969chr20:34078460ENST00000262975-20241147_11861019.33333333333341169.0PRKCB1
HgeneZMYND8chr20:45852969chr20:34078460ENST00000311275-19221147_11861065.33333333333331187.0PRKCB1
HgeneZMYND8chr20:45852969chr20:34078460ENST00000352431-19221147_11861039.33333333333331161.0PRKCB1
HgeneZMYND8chr20:45852969chr20:34078460ENST00000355972-20241147_11861065.33333333333331215.0PRKCB1
HgeneZMYND8chr20:45852969chr20:34078460ENST00000360911-19221147_11861014.33333333333341136.0PRKCB1
HgeneZMYND8chr20:45852969chr20:34078460ENST00000461685-19231147_11861039.33333333333331189.0PRKCB1
HgeneZMYND8chr20:45852969chr20:34078460ENST00000471951-19231147_11861085.33333333333331235.0PRKCB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZMYND8-CEP250


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZMYND8-CEP250


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource