Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZMYND8-TFE3 (FusionGDB2 ID:100728)

Fusion Gene Summary for ZMYND8-TFE3

Fusion gene summary

Fusion gene information	Fusion gene name: ZMYND8-TFE3
	Fusion gene ID: 100728
		Hgene	Tgene
	Gene symbol	ZMYND8	TFE3
	Gene ID	23613	7030
	Gene name	zinc finger MYND-type containing 8	transcription factor binding to IGHM enhancer 3
	Synonyms	PRKCBP1\|PRO2893\|RACK7	RCCP2\|RCCX1\|TFEA\|bHLHe33
	Cytomap	20q13.12	Xp11.23
	Type of gene	protein-coding	protein-coding
	Description	protein kinase C-binding protein 1CTCL tumor antigen se14-3cutaneous T-cell lymphoma-associated antigen se14-3predicted protein of HQ2893zinc finger MYND domain-containing protein 8	transcription factor E3class E basic helix-loop-helix protein 33transcription factor E family, member Atranscription factor for IgH enhancertranscription factor for immunoglobulin heavy-chain enhancer 3
	Modification date	20200313	20200327
	UniProtAcc	.	P19532
	Ensembl transtripts involved in fusion gene	ENST00000311275, ENST00000360911, ENST00000458360, ENST00000262975, ENST00000471951, ENST00000352431, ENST00000396281, ENST00000446994, ENST00000536340, ENST00000355972, ENST00000540497, ENST00000461685, ENST00000372023, ENST00000468376,	ENST00000315869, ENST00000487451,
Fusion gene scores	* DoF score	25 X 23 X 10=5750	14 X 15 X 6=1260
	# samples	34	15
	** MAII score	log2(34/5750*10)=-4.0799553045814 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1260*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZMYND8 [Title/Abstract] AND TFE3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZMYND8(45849965)-TFE3(48896935), # samples:2
Anticipated loss of major functional domain due to fusion event.	ZMYND8-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ZMYND8-TFE3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ZMYND8-TFE3 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. ZMYND8-TFE3 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. ZMYND8-TFE3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. ZMYND8-TFE3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across ZMYND8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TFE3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-B5-A3FB-01A	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
ChimerDB4	UCEC	TCGA-B5-A3FB-01A	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-

Top

Fusion Gene ORF analysis for ZMYND8-TFE3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000311275	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
5CDS-intron	ENST00000311275	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
Frame-shift	ENST00000360911	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
5CDS-intron	ENST00000360911	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
Frame-shift	ENST00000458360	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
5CDS-intron	ENST00000458360	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
In-frame	ENST00000262975	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
5CDS-intron	ENST00000262975	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
Frame-shift	ENST00000471951	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
5CDS-intron	ENST00000471951	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
Frame-shift	ENST00000352431	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
5CDS-intron	ENST00000352431	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
Frame-shift	ENST00000396281	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
5CDS-intron	ENST00000396281	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
In-frame	ENST00000446994	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
5CDS-intron	ENST00000446994	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
Frame-shift	ENST00000536340	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
5CDS-intron	ENST00000536340	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
In-frame	ENST00000355972	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
5CDS-intron	ENST00000355972	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
Frame-shift	ENST00000540497	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
5CDS-intron	ENST00000540497	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
Frame-shift	ENST00000461685	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
5CDS-intron	ENST00000461685	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
Frame-shift	ENST00000372023	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
5CDS-intron	ENST00000372023	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
intron-3CDS	ENST00000468376	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-
intron-intron	ENST00000468376	ENST00000487451	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262975	ZMYND8	chr20	45849965	-	ENST00000315869	TFE3	chrX	48896935	-	6428	3503	239	3667	1142
ENST00000446994	ZMYND8	chr20	45849965	-	ENST00000315869	TFE3	chrX	48896935	-	6044	3119	44	3283	1079
ENST00000355972	ZMYND8	chr20	45849965	-	ENST00000315869	TFE3	chrX	48896935	-	6442	3517	115	3681	1188

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262975	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-	0.003532143	0.9964678
ENST00000446994	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-	0.002977521	0.99702245
ENST00000355972	ENST00000315869	ZMYND8	chr20	45849965	-	TFE3	chrX	48896935	-	0.004038085	0.99596196

Top

Fusion Genomic Features for ZMYND8-TFE3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ZMYND8-TFE3

Go to
FGviewer for the breakpoints of chr20:45849965-chrX:48896935
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	TFE3 P19532
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:29146937, PubMed:30733432, PubMed:31672913). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:31672913). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:31672913). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent nuclear exclusion promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). {ECO:0000250\|UniProtKB:Q64092, ECO:0000269\|PubMed:2338243, ECO:0000269\|PubMed:29146937, ECO:0000269\|PubMed:30733432, ECO:0000269\|PubMed:31672913}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000262975

43_47

1073.0

1169.0

Compositional bias

Note=Poly-Lys

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000262975

838_854

1073.0

1169.0

Compositional bias

Note=Poly-Gln

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000311275

1089_1092

1119.0

1187.0

Compositional bias

Note=Poly-Ser

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000311275

43_47

1119.0

1187.0

Compositional bias

Note=Poly-Lys

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000311275

838_854

1119.0

1187.0

Compositional bias

Note=Poly-Gln

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000352431

1089_1092

1093.0

1161.0

Compositional bias

Note=Poly-Ser

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000352431

43_47

1093.0

1161.0

Compositional bias

Note=Poly-Lys

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000352431

838_854

1093.0

1161.0

Compositional bias

Note=Poly-Gln

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000355972

1089_1092

1119.0

1215.0

Compositional bias

Note=Poly-Ser

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000355972

43_47

1119.0

1215.0

Compositional bias

Note=Poly-Lys

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000355972

838_854

1119.0

1215.0

Compositional bias

Note=Poly-Gln

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000360911

43_47

1068.0

1136.0

Compositional bias

Note=Poly-Lys

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000360911

838_854

1068.0

1136.0

Compositional bias

Note=Poly-Gln

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000461685

1089_1092

1093.0

1189.0

Compositional bias

Note=Poly-Ser

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000461685

43_47

1093.0

1189.0

Compositional bias

Note=Poly-Lys

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000461685

838_854

1093.0

1189.0

Compositional bias

Note=Poly-Gln

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000471951

1089_1092

1139.0

1235.0

Compositional bias

Note=Poly-Ser

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000471951

43_47

1139.0

1235.0

Compositional bias

Note=Poly-Lys

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000471951

838_854

1139.0

1235.0

Compositional bias

Note=Poly-Gln

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000262975

165_235

1073.0

1169.0

Domain

Bromo

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000262975

277_327

1073.0

1169.0

Domain

PWWP

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000311275

165_235

1119.0

1187.0

Domain

Bromo

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000311275

277_327

1119.0

1187.0

Domain

PWWP

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000352431

165_235

1093.0

1161.0

Domain

Bromo

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000352431

277_327

1093.0

1161.0

Domain

PWWP

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000355972

165_235

1119.0

1215.0

Domain

Bromo

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000355972

277_327

1119.0

1215.0

Domain

PWWP

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000360911

165_235

1068.0

1136.0

Domain

Bromo

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000360911

277_327

1068.0

1136.0

Domain

PWWP

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000461685

165_235

1093.0

1189.0

Domain

Bromo

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000461685

277_327

1093.0

1189.0

Domain

PWWP

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000471951

165_235

1139.0

1235.0

Domain

Bromo

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000471951

277_327

1139.0

1235.0

Domain

PWWP

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000262975

1028_1062

1073.0

1169.0

Zinc finger

MYND-type

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000262975

88_133

1073.0

1169.0

Zinc finger

PHD-type

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000311275

1028_1062

1119.0

1187.0

Zinc finger

MYND-type

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000311275

88_133

1119.0

1187.0

Zinc finger

PHD-type

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000352431

1028_1062

1093.0

1161.0

Zinc finger

MYND-type

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000352431

88_133

1093.0

1161.0

Zinc finger

PHD-type

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000355972

1028_1062

1119.0

1215.0

Zinc finger

MYND-type

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000355972

88_133

1119.0

1215.0

Zinc finger

PHD-type

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000360911

1028_1062

1068.0

1136.0

Zinc finger

MYND-type

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000360911

88_133

1068.0

1136.0

Zinc finger

PHD-type

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000461685

1028_1062

1093.0

1189.0

Zinc finger

MYND-type

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000461685

88_133

1093.0

1189.0

Zinc finger

PHD-type

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000471951

1028_1062

1139.0

1235.0

Zinc finger

MYND-type

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000471951

88_133

1139.0

1235.0

Zinc finger

PHD-type

Tgene

TFE3

chr20:45849965

chrX:48896935

ENST00000315869

346_399

76.66666666666667

576.0

Domain

bHLH

Tgene

TFE3

chr20:45849965

chrX:48896935

ENST00000315869

260_271

76.66666666666667

576.0

Region

Strong transcription activation domain

Tgene

TFE3

chr20:45849965

chrX:48896935

ENST00000315869

409_430

76.66666666666667

576.0

Region

Note=Leucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000262975

1089_1092

1073.0

1169.0

Compositional bias

Note=Poly-Ser

Hgene

ZMYND8

chr20:45849965

chrX:48896935

ENST00000360911

1089_1092

1068.0

1136.0

Compositional bias

Note=Poly-Ser

Top

Fusion Gene Sequence for ZMYND8-TFE3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000262975_ENST00000315869_TCGA-B5-A3FB-01A_ZMYND8_chr20_45849965_-_TFE3_chrX_48896935_length(transcript)=6428nt_BP=3503nt
CGGCTTTACACTCCGATTTGCCGGGGCAGCCAATCGGGGATGAGCTTTTATTAGGCGGCCAGATCATCAGCCGAAGTGCCAAACCCTTTT
TCTGTGAGAACTAGGAGCCTGTCCTCCATGTTTTATAAGTATTGACATTACACAGTGTTAACAATGCATCCACAGAGTCCCAAATCTGCC
AGCCTGTTCTCTCTTCCTAACTGTGGAAAAATGAGACGGTTGCTTGAACATTTGTTGGCTTGGCTGAAGAGGAAATAAAAACAGAACAGG
AGGTGGTAGAGGGCATGGATATCTCTACTCGCTCCAAAGATCCTGGCTCTGCAGAGAGAACAGCCCAGAAAAGAAAGTTCCCCAGCCCTC
CACATTCTTCCAATGGCCACTCGCCGCAGGACACATCAACAAGCCCCATTAAAAAGAAAAAGAAACCTGGCTTACTGAACAGTAACAATA
AGGAGCAGTCAGAACTAAGACATGGTCCGTTTTACTATATGAAGCAGCCACTCACCACAGACCCTGTTGATGTTGTACCGCAGGATGGAC
GGAATGATTTCTACTGCTGGGTTTGTCACCGGGAAGGCCAAGTCCTTTGCTGTGAGCTCTGTCCCCGGGTTTATCACGCTAAGTGTCTGA
GACTGACATCGGAACCAGAGGGGGACTGGTTTTGTCCTGAATGTGAGAAAATTACAGTAGCAGAATGCATCGAGACCCAGAGTAAAGCCA
TGACAATGCTCACCATTGAACAGTTATCCTACCTGCTCAAGTTTGCCATTCAGAAAATGAAACAGCCAGGGACAGATGCATTCCAGAAGC
CCGTTCCATTGGAACAGCACCCTGACTATGCGGAATACATCTTCCATCCAATGGACCTTTGTACATTGGAAAAGAATGCGAAAAAGAAAA
TGTATGGCTGCACAGAAGCCTTCCTGGCTGATGCAAAGTGGATTTTGCACAACTGCATCATTTATAATGGGGGAAATCACAAATTGACGC
AAATAGCGAAAGTAGTCATCAAAATCTGTGAACATGAGATGAATGAAATCGAAGTATGTCCAGAATGTTATCTAGCTGCTTGCCAAAAAC
GAGATAACTGGTTTTGTGAGCCTTGTAGCAATCCACATCCTTTGGTCTGGGCCAAACTGAAGGGGTTTCCATTCTGGCCTGCAAAAGCTC
TAAGGGATAAAGACGGGCAGGTCGATGCCCGATTCTTTGGACAACATGACAGGGCCTGGGTTCCAATAAATAATTGCTACCTCATGTCTA
AAGAAATTCCTTTTTCTGTGAAAAAGACTAAGAGCATCTTCAACAGTGCCATGCAAGAGATGGAGGTTTACGTGGAGAACATCCGCAGGA
AGTTTGGGGTTTTTAATTACTCTCCATTTAGGACACCCTACACACCCAACAGCCAGTATCAAATGCTGCTCGATCCCACCAACCCCAGCG
CCGGCACTGCCAAGATAGACAAGCAGGAGAAGGTCAAGCTCAACTTTGACATGACGGCATCCCCCAAGATCCTGATGAGCAAGCCTGTGC
TGAGTGGGGGCACAGGCCGCCGGATTTCCTTGTCGGATATGCCGCGCTCCCCCATGAGCACAAACTCTTCTGTGCACACGGGCTCCGACG
TGGAGCAGGATGCTGAGAAGAAGGCCACGTCGAGCCACTTCAGTGCGAGCGAGGAGTCCATGGACTTCCTGGATAAGAGCACAGCTTCAC
CAGCCTCCACCAAGACGGGACAAGCAGGGAGTTTATCCGGCAGCCCAAAGCCCTTCTCTCCTCAACTGTCAGCTCCTATCACGACGAAAA
CGGACAAAACCTCCACCACCGGCAGCATCCTGAATCTTAACCTGGATCGAAGCAAAGCTGAGATGGATTTGAAGGAGCTGAGCGAGTCGG
TCCAGCAACAGTCCACCCCTGTTCCTCTCATCTCTCCCAAGCGCCAGATTCGTAGCAGGTTCCAGCTGAATCTTGACAAGACCATAGAGA
GTTGCAAAGCACAATTAGGCATAAATGAAATCTCGGAAGATGTCTATACGGCCGTAGAGCACAGCGATTCGGAGGATTCTGAGAAGTCAG
ATAGTAGCGATAGTGAGTATATCAGTGATGATGAGCAGAAGTCTAAGAACGAGCCAGAAGACACAGAGGACAAAGAAGGTTGTCAGATGG
ACAAAGAGCCATCTGCTGTTAAAAAAAAGCCCAAGCCTACAAACCCAGTGGAGATTAAAGAGGAGCTGAAAAGCACGTCACCAGCCAGCG
AGAAGGCAGACCCTGGAGCAGTCAAGGACAAGGCCAGCCCTGAGCCTGAGAAGGACTTTTCCGAAAAGGCAAAACCTTCACCTCACCCCA
TAAAGGATAAACTGAAGGGAAAAGATGAGACGGATTCCCCAACAGTCCATTTGGGCCTGGACTCTGATTCAGAGAGCGAACTTGTCATAG
ATTTAGGAGAAGACCATTCTGGGCGGGAGGGTCGAAAAAATAAGAAGGAACCCAAAGAACCATCTCCCAAACAGGATGTTGTAGGTAAAA
CTCCACCATCCACGACGGTGGGCAGCCATTCTCCCCCGGAAACACCGGTGCTCACCCGCTCTTCCGCCCAAACTTCCGCGGCTGGCGCCA
CAGCCACCACCAGCACGTCCTCCACGGTCACCGTCACGGCCCCGGCCCCCGCCGCCACAGGAAGCCCAGTGAAAAAGCAGAGGCCGCTTT
TACCGAAGGAGACTGCCCCGGCCGTGCAGCGGGTCGTGTGGAACTCATCAACTGTCCAGCAGAAGGAGATCACACAGAGCCCATCCACGT
CCACCATCACCCTGGTGACCAGCACACAGTCATCGCCCCTGGTCACCAGCTCGGGGTCCATGAGCACCCTTGTGTCCTCAGTCAACGCTG
ACCTGCCCATCGCCACTGCCTCAGCTGATGTCGCCGCTGATATTGCCAAGTACACTAGCAAAATGATGGATGCAATAAAAGGAACAATGA
CAGAAATATACAACGATCTTTCTAAAAACACTACTGGAAGCACAATAGCTGAGATTCGCAGGCTGAGGATCGAGATAGAGAAGCTCCAGT
GGCTGCACCAGCAAGAGCTCTCCGAAATGAAACACAACTTAGAGCTGACCATGGCGGAGATGCGGCAGAGCCTGGAGCAGGAGCGGGACC
GGCTCATCGCCGAGGTGAAGAAGCAGCTGGAGTTGGAGAAGCAGCAGGCGGTGGATGAGACCAAGAAGAAGCAGTGGTGCGCCAACTGCA
AGAAGGAGGCCATCTTTTACTGCTGTTGGAACACTAGCTACTGTGACTACCCCTGCCAGCAAGCCCACTGGCCTGAGCACATGAAGTCCT
GCACCCAGTCAGCTACTGCTCCTCAGCAGGAAGCGGATGCTGAGGTGAACACAGAAACACTAAATAAGTCCTCCCAGGGGAGCTCCTCGA
GCACACAATCAGCACCTTCAGAAACGGCCAGCGCCTCCAAAGAGAAGGAGACGTCAGCTGAGAAAAGCAAGGAGAGTGGCTCGCCTCCCA
ATATCACTGCAGGCCACACCAGCCACCCCAGCTACACTCTCTGCATCGTCTTCTGCAGGGGGCTCCAGGACCCCTGCCATGTCGTCATCT
TCTTCATCGAGGGTCTTGCTGCGGCAGCAGCTAATGCGGGCCCAGGCGCAGGAGCAGGAGAGGCGTGAGCGTCGGGAACAGGCCGCCGCG
GCTCCCTTCCCCAGTCCTGCACCTGCCTCTCCTGCCATCTCTGTGGTTGGCGTCTCTGCTGGGGGCCACACATTGAGCCGTCCACCCCCT
GCTCAGGTGCCCAGGGAGGTGCTCAAGGTGCAGACCCATCTGGAGAACCCAACGCGCTACCACCTGCAGCAGGCGCGCCGGCAGCAGGTG
AAACAGTACCTGTCCACCACACTCGGGCCCAAGCTGGCTTCCCAGGCCCTCACCCCACCGCCGGGGCCCGCAAGTGCCCAGCCACTGCCT
GCCCCTGAGGCTGCCCACACTACCGGCCCCACAGGCAGTGCGCCCAACAGCCCCATGGCGCTGCTCACCATCGGGTCCAGCTCAGAGAAG
GAGATTGATGATGTCATTGATGAGATCATCAGCCTGGAGTCCAGTTACAATGATGAAATGCTCAGCTATCTGCCCGGAGGCACCACAGGA
CTGCAGCTCCCCAGCACGCTGCCTGTGTCAGGGAATCTGCTTGATGTGTACAGTAGTCAAGGCGTGGCCACACCAGCCATCACTGTCAGC
AACTCCTGCCCAGCTGAGCTGCCCAACATCAAACGGGAGATCTCTGAGACCGAGGCAAAGGCCCTTTTGAAGGAACGGCAGAAGAAAGAC
AATCACAACCTAATTGAGCGTCGCAGGCGATTCAACATTAACGACAGGATCAAGGAACTGGGCACTCTCATCCCTAAGTCCAGTGACCCG
GAGATGCGCTGGAACAAGGGCACCATCCTGAAGGCCTCTGTGGATTATATCCGCAAGCTGCAGAAGGAGCAGCAGCGCTCCAAAGACCTG
GAGAGCCGGCAGCGATCCCTGGAGCAGGCCAACCGCAGCCTGCAGCTCCGAATTCAGGAACTAGAACTGCAGGCCCAGATCCATGGCCTG
CCAGTACCTCCCACTCCAGGGCTGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAAGCCAGAGCAGCTGGACATTGAGGAGGAG
GGCAGGCCAGGCGCAGCAACGTTCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCAGCAGCCCCCTGCACCGCCCTCAGATGCC
CTTCTGGACCTGCACTTTCCCAGCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGGGCTGGAGGACATTCTGATGGAGGAGGAG
GAGGGGGTGGTGGGAGGACTGTCGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCCCCTGCTCTCTTCAGTGTCCCCTGCTGTC
TCCAAGGCCAGCAGCCGCCGCAGCAGCTTCAGCATGGAAGAGGAGTCCTGATCAGGCCTCACCCCTCCCCTGGGACTTTCCCACCCAGGA
AAGGAGGACCAGTCAGGATGAGGCCCCGCCTTTTCCCCCACCCTCCCATGAGACTGCCCTGCCCAGGTATCCTGGGGGAAGAGGAGATGT
GATCAGGCCCCACCCCTGTAATCAGGCAAGGAGGAGGAGTCAGATGAGGCCCTGCACCTTCCCCAAAGGAACCGCCCAGTGCAGGTATTT
CAGAAGGAGAAGGCTGGAGAAGGACATGAGATCAGGGCCTGCCCCCTGGGGATCACAGCCTCACCCCTGCCCCTGTGGGACTCATCCTTG
CCCAGGTGAGGGAAGGAGACAGGATGAGGTCTCGACCCTGTCCCCTAGGGACTGTCCTAGCCAGGTCTCCTGGGAAAGGGAGATGTCAGG
ATGTTGCTCCATCCTTTGTCTTGGAACCACCAGTCTAGTCCGTCCTGGCACAGAAGAGGAGTCAAGTAATGGAGGTCCCAGCCCTGGGGG
TTTAAGCTCTGCCCCTTCCCCATGAACCCTGCCCTGCTCTGCCCAGGCAAGGAACAGAAGTGAGGATGAGACCCAGCCCCTTCCCCTGGG
AACTCTCCTGGCCTTCTAGGAATGGAGGAGCCAGGCCCCACCCCTTCCCTATAGGAACAGCCCAGCACAGGTATTTCAGGTGTGAAAGAA
TCAGTAGGACCAGGCCACCGCTAGTGCTTGTGGAGATCACAGCCCCACCCTTGTCCCTCAGCAACATCCCATCTAAGCATTCCACACTGC
AGGGAGGAGTGGTACTTAAGCTCCCCTGCCTTAACCTGGGACCAACCTGACCTAACCTAGGAGGGCTCTGAGCCAACCTTGCTCTTGGGG
AAGGGGACAGATTATGAAATTTCATGGATGAATTTTCCAGACCTATATCTGGAGTGAGAGGCCCCCACCCTTGGGCAGAGTCCTGCCTTC
TTCCTTGAGGGGCAGTTTGGGAAGGTGATGGGTATTAGTGGGGGACTGAGTTCAGGTTACCAGAACCAGTACCTCAGTATTCTTTTTCAA
CATGTAGGGCAAGAGGATGAAGGAAGGGGCTATCCTGGGACCTCCCCAGCCCAGGAAAAACTGGAAGCCTTCCCCCAGCAAGGCAGAAGC
TTGGAGGAGGGTTGTAAAAGCATATTGTACCCCCTCATTTGTTTATCTGATTTTTTTATTGCTCCGCATACTGAGAATCTAGGCCACCCC
AACCTCTGTTCCCCACCCAGTTCTTCATTTGGAGGAATCACCCCATTTCAGAGTTATCAAGAGACACTCCCCCCTCCATTCCCACCCCTC
ATACCTACACCCAAGGTTGTCAGCTTTGGATTGCTGGGGCCAGGCCCCATGGAGGGTATACTGAGGGGTCTATAGGTTTGTGATTAAAAT

>In-frame_ENST00000262975_ENST00000315869_TCGA-B5-A3FB-01A_ZMYND8_chr20_45849965_-_TFE3_chrX_48896935_length(amino acids)=1142AA_start in transcript=239_stop in transcript=3667
MAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTT
DPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKM
KQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVC
PECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQE
MEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMS
TNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKA
EMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPE
DTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGL
DSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAAT
GSPVKKQRPLLPKETAPAVQRVVWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTS
KMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDE
TKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSA

--------------------------------------------------------------
>In-frame_ENST00000446994_ENST00000315869_TCGA-B5-A3FB-01A_ZMYND8_chr20_45849965_-_TFE3_chrX_48896935_length(transcript)=6044nt_BP=3119nt
GTTAATTCTCAGGCTCTGTTGGGGGTGGTCAGAAATCTAATTTCTTGGCTGAAGAGGAAATAAAAACAGAACAGGAGGTGGTAGAGGGCA
TGGATATCTCTACTCGCTCCAAAGATCCTGGCTCTGCAGAGAGAACAGCCCAGAAAAGAAAGTTCCCCAGCCCTCCACATTCTTCCAATG
GCCACTCGCCGCAGGACACATCAACAAGCCCCATTAAAAAGAAAAAGAAACCTGGCTTACTGAACAGTAACAATAAGGAGCAGGATGGAC
GGAATGATTTCTACTGCTGGGTTTGTCACCGGGAAGGCCAAGTCCTTTGCTGTGAGCTCTGTCCCCGGGTTTATCACGCTAAGTGTCTGA
GACTGACATCGGAACCAGAGGGGGACTGGTTTTGTCCTGAATGTGAGACAGATGCATTCCAGAAGCCCGTTCCATTGGAACAGCACCCTG
ACTATGCGGAATACATCTTCCATCCAATGGACCTTTGTACATTGGAAAAGAATGCGAAAAAGAAAATGTATGGCTGCACAGAAGCCTTCC
TGGCTGATGCAAAGTGGATTTTGCACAACTGCATCATTTATAATGGGGGAAATCACAAATTGACGCAAATAGCGAAAGTAGTCATCAAAA
TCTGTGAACATGAGATGAATGAAATCGAAGTATGTCCAGAATGTTATCTAGCTGCTTGCCAAAAACGAGATAACTGGTTTTGTGAGCCTT
GTAGCAATCCACATCCTTTGGTCTGGGCCAAACTGAAGGGGTTTCCATTCTGGCCTGCAAAAGCTCTAAGGGATAAAGACGGGCAGGTCG
ATGCCCGATTCTTTGGACAACATGACAGGGCCTGGGTTCCAATAAATAATTGCTACCTCATGTCTAAAGAAATTCCTTTTTCTGTGAAAA
AGACTAAGAGCATCTTCAACAGTGCCATGCAAGAGATGGAGGTTTACGTGGAGAACATCCGCAGGAAGTTTGGGGTTTTTAATTACTCTC
CATTTAGGACACCCTACACACCCAACAGCCAGTATCAAATGCTGCTCGATCCCACCAACCCCAGCGCCGGCACTGCCAAGATAGACAAGC
AGGAGAAGGTCAAGCTCAACTTTGACATGACGGCATCCCCCAAGATCCTGATGAGCAAGCCTGTGCTGAGTGGGGGCACAGGCCGCCGGA
TTTCCTTGTCGGATATGCCGCGCTCCCCCATGAGCACAAACTCTTCTGTGCACACGGGCTCCGACGTGGAGCAGGATGCTGAGAAGAAGG
CCACGTCGAGCCACTTCAGTGCGAGCGAGGAGTCCATGGACTTCCTGGATAAGAGCACAGCTTCACCAGCCTCCACCAAGACGGGACAAG
CAGGGAGTTTATCCGGCAGCCCAAAGCCCTTCTCTCCTCAACTGTCAGCTCCTATCACGACGAAAACGGACAAAACCTCCACCACCGGCA
GCATCCTGAATCTTAACCTGGATCGAAGCAAAGCTGAGATGGATTTGAAGGAGCTGAGCGAGTCGGTCCAGCAACAGTCCACCCCTGTTC
CTCTCATCTCTCCCAAGCGCCAGATTCGTAGCAGGTTCCAGCTGAATCTTGACAAGACCATAGAGAGTTGCAAAGCACAATTAGGCATAA
ATGAAATCTCGGAAGATGTCTATACGGCCGTAGAGCACAGCGATTCGGAGGATTCTGAGAAGTCAGATAGTAGCGATAGTGAGTATATCA
GTGATGATGAGCAGAAGTCTAAGAACGAGCCAGAAGACACAGAGGACAAAGAAGGTTGTCAGATGGACAAAGAGCCATCTGCTGTTAAAA
AAAAGCCCAAGCCTACAAACCCAGTGGAGATTAAAGAGGAGCTGAAAAGCACGTCACCAGCCAGCGAGAAGGCAGACCCTGGAGCAGTCA
AGGACAAGGCCAGCCCTGAGCCTGAGAAGGACTTTTCCGAAAAGGCAAAACCTTCACCTCACCCCATAAAGGATAAACTGAAGGGAAAAG
ATGAGACGGATTCCCCAACAGTCCATTTGGGCCTGGACTCTGATTCAGAGAGCGAACTTGTCATAGATTTAGGAGAAGACCATTCTGGGC
GGGAGGGTCGAAAAAATAAGAAGGAACCCAAAGAACCATCTCCCAAACAGGATGTTGTAGGTAAAACTCCACCATCCACGACGGTGGGCA
GCCATTCTCCCCCGGAAACACCGGTGCTCACCCGCTCTTCCGCCCAAACTTCCGCGGCTGGCGCCACAGCCACCACCAGCACGTCCTCCA
CGGTCACCGTCACGGCCCCGGCCCCCGCCGCCACAGGAAGCCCAGTGAAAAAGCAGAGGCCGCTTTTACCGAAGGAGACTGCCCCGGCCG
TGCAGCGGGTCGTGTGGAACTCATCAACTGTCCAGCAGAAGGAGATCACACAGAGCCCATCCACGTCCACCATCACCCTGGTGACCAGCA
CACAGTCATCGCCCCTGGTCACCAGCTCGGGGTCCATGAGCACCCTTGTGTCCTCAGTCAACGCTGACCTGCCCATCGCCACTGCCTCAG
CTGATGTCGCCGCTGATATTGCCAAGTACACTAGCAAAATGATGGATGCAATAAAAGGAACAATGACAGAAATATACAACGATCTTTCTA
AAAACACTACTGGAAGCACAATAGCTGAGATTCGCAGGCTGAGGATCGAGATAGAGAAGCTCCAGTGGCTGCACCAGCAAGAGCTCTCCG
AAATGAAACACAACTTAGAGCTGACCATGGCGGAGATGCGGCAGAGCCTGGAGCAGGAGCGGGACCGGCTCATCGCCGAGGTGAAGAAGC
AGCTGGAGTTGGAGAAGCAGCAGGCGGTGGATGAGACCAAGAAGAAGCAGTGGTGCGCCAACTGCAAGAAGGAGGCCATCTTTTACTGCT
GTTGGAACACTAGCTACTGTGACTACCCCTGCCAGCAAGCCCACTGGCCTGAGCACATGAAGTCCTGCACCCAGTCAGCTACTGCTCCTC
AGCAGGAAGCGGATGCTGAGGTGAACACAGAAACACTAAATAAGTCCTCCCAGGGGAGCTCCTCGAGCACACAATCAGCACCTTCAGAAA
CGGCCAGCGCCTCCAAAGAGAAGGAGACGTCAGCTGAGAAAAGCAAGGAGAGTGGCTCGCCTCCCAATATCACTGCAGGCCACACCAGCC
ACCCCAGCTACACTCTCTGCATCGTCTTCTGCAGGGGGCTCCAGGACCCCTGCCATGTCGTCATCTTCTTCATCGAGGGTCTTGCTGCGG
CAGCAGCTAATGCGGGCCCAGGCGCAGGAGCAGGAGAGGCGTGAGCGTCGGGAACAGGCCGCCGCGGCTCCCTTCCCCAGTCCTGCACCT
GCCTCTCCTGCCATCTCTGTGGTTGGCGTCTCTGCTGGGGGCCACACATTGAGCCGTCCACCCCCTGCTCAGGTGCCCAGGGAGGTGCTC
AAGGTGCAGACCCATCTGGAGAACCCAACGCGCTACCACCTGCAGCAGGCGCGCCGGCAGCAGGTGAAACAGTACCTGTCCACCACACTC
GGGCCCAAGCTGGCTTCCCAGGCCCTCACCCCACCGCCGGGGCCCGCAAGTGCCCAGCCACTGCCTGCCCCTGAGGCTGCCCACACTACC
GGCCCCACAGGCAGTGCGCCCAACAGCCCCATGGCGCTGCTCACCATCGGGTCCAGCTCAGAGAAGGAGATTGATGATGTCATTGATGAG
ATCATCAGCCTGGAGTCCAGTTACAATGATGAAATGCTCAGCTATCTGCCCGGAGGCACCACAGGACTGCAGCTCCCCAGCACGCTGCCT
GTGTCAGGGAATCTGCTTGATGTGTACAGTAGTCAAGGCGTGGCCACACCAGCCATCACTGTCAGCAACTCCTGCCCAGCTGAGCTGCCC
AACATCAAACGGGAGATCTCTGAGACCGAGGCAAAGGCCCTTTTGAAGGAACGGCAGAAGAAAGACAATCACAACCTAATTGAGCGTCGC
AGGCGATTCAACATTAACGACAGGATCAAGGAACTGGGCACTCTCATCCCTAAGTCCAGTGACCCGGAGATGCGCTGGAACAAGGGCACC
ATCCTGAAGGCCTCTGTGGATTATATCCGCAAGCTGCAGAAGGAGCAGCAGCGCTCCAAAGACCTGGAGAGCCGGCAGCGATCCCTGGAG
CAGGCCAACCGCAGCCTGCAGCTCCGAATTCAGGAACTAGAACTGCAGGCCCAGATCCATGGCCTGCCAGTACCTCCCACTCCAGGGCTG
CTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAAGCCAGAGCAGCTGGACATTGAGGAGGAGGGCAGGCCAGGCGCAGCAACGTTC
CATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCAGCAGCCCCCTGCACCGCCCTCAGATGCCCTTCTGGACCTGCACTTTCCCAGC
GACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGGGCTGGAGGACATTCTGATGGAGGAGGAGGAGGGGGTGGTGGGAGGACTGTCG
GGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCCCCTGCTCTCTTCAGTGTCCCCTGCTGTCTCCAAGGCCAGCAGCCGCCGCAGC
AGCTTCAGCATGGAAGAGGAGTCCTGATCAGGCCTCACCCCTCCCCTGGGACTTTCCCACCCAGGAAAGGAGGACCAGTCAGGATGAGGC
CCCGCCTTTTCCCCCACCCTCCCATGAGACTGCCCTGCCCAGGTATCCTGGGGGAAGAGGAGATGTGATCAGGCCCCACCCCTGTAATCA
GGCAAGGAGGAGGAGTCAGATGAGGCCCTGCACCTTCCCCAAAGGAACCGCCCAGTGCAGGTATTTCAGAAGGAGAAGGCTGGAGAAGGA
CATGAGATCAGGGCCTGCCCCCTGGGGATCACAGCCTCACCCCTGCCCCTGTGGGACTCATCCTTGCCCAGGTGAGGGAAGGAGACAGGA
TGAGGTCTCGACCCTGTCCCCTAGGGACTGTCCTAGCCAGGTCTCCTGGGAAAGGGAGATGTCAGGATGTTGCTCCATCCTTTGTCTTGG
AACCACCAGTCTAGTCCGTCCTGGCACAGAAGAGGAGTCAAGTAATGGAGGTCCCAGCCCTGGGGGTTTAAGCTCTGCCCCTTCCCCATG
AACCCTGCCCTGCTCTGCCCAGGCAAGGAACAGAAGTGAGGATGAGACCCAGCCCCTTCCCCTGGGAACTCTCCTGGCCTTCTAGGAATG
GAGGAGCCAGGCCCCACCCCTTCCCTATAGGAACAGCCCAGCACAGGTATTTCAGGTGTGAAAGAATCAGTAGGACCAGGCCACCGCTAG
TGCTTGTGGAGATCACAGCCCCACCCTTGTCCCTCAGCAACATCCCATCTAAGCATTCCACACTGCAGGGAGGAGTGGTACTTAAGCTCC
CCTGCCTTAACCTGGGACCAACCTGACCTAACCTAGGAGGGCTCTGAGCCAACCTTGCTCTTGGGGAAGGGGACAGATTATGAAATTTCA
TGGATGAATTTTCCAGACCTATATCTGGAGTGAGAGGCCCCCACCCTTGGGCAGAGTCCTGCCTTCTTCCTTGAGGGGCAGTTTGGGAAG
GTGATGGGTATTAGTGGGGGACTGAGTTCAGGTTACCAGAACCAGTACCTCAGTATTCTTTTTCAACATGTAGGGCAAGAGGATGAAGGA
AGGGGCTATCCTGGGACCTCCCCAGCCCAGGAAAAACTGGAAGCCTTCCCCCAGCAAGGCAGAAGCTTGGAGGAGGGTTGTAAAAGCATA
TTGTACCCCCTCATTTGTTTATCTGATTTTTTTATTGCTCCGCATACTGAGAATCTAGGCCACCCCAACCTCTGTTCCCCACCCAGTTCT
TCATTTGGAGGAATCACCCCATTTCAGAGTTATCAAGAGACACTCCCCCCTCCATTCCCACCCCTCATACCTACACCCAAGGTTGTCAGC
TTTGGATTGCTGGGGCCAGGCCCCATGGAGGGTATACTGAGGGGTCTATAGGTTTGTGATTAAAATAATAAAAGCTAGGCGTGTTTGATG

>In-frame_ENST00000446994_ENST00000315869_TCGA-B5-A3FB-01A_ZMYND8_chr20_45849965_-_TFE3_chrX_48896935_length(amino acids)=1079AA_start in transcript=44_stop in transcript=3283
MAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQDGRNDFYCWVCHREGQV
LCCELCPRVYHAKCLRLTSEPEGDWFCPECETDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYN
GGNHKLTQIAKVVIKICEHEMNEIEVCPECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPI
NNCYLMSKEIPFSVKKTKSIFNSAMQEMEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPK
ILMSKPVLSGGTGRRISLSDMPRSPMSTNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQL
SAPITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSD
SEDSEKSDSSDSEYISDDEQKSKNEPEDTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEK
AKPSPHPIKDKLKGKDETDSPTVHLGLDSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSA
QTSAAGATATTSTSSTVTVTAPAPAATGSPVKKQRPLLPKETAPAVQRVVWNSSTVQQKEITQSPSTSTITLVTSTQSSPLVTSSGSMST
LVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQQELSEMKHNLELTMAEMRQ
SLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQSATAPQQEADAEVNTETLNK

--------------------------------------------------------------
>In-frame_ENST00000355972_ENST00000315869_TCGA-B5-A3FB-01A_ZMYND8_chr20_45849965_-_TFE3_chrX_48896935_length(transcript)=6442nt_BP=3517nt
ATAAGTATTGACATTACACAGTGTTAACAATGCATCCACAGAGTCCCAAATCTGCCAGCCTGTTCTCTCTTCCTAACTGTGGAAAAATGA
GACGGTTGCTTGAACATTTGTTGGCTTGGCTGAAGAGGAAATAAAAACAGAACAGGAGGTGGTAGAGGGCATGGATATCTCTACTCGCTC
CAAAGATCCTGGCTCTGCAGAGAGAACAGCCCAGAAAAGAAAGTTCCCCAGCCCTCCACATTCTTCCAATGGCCACTCGCCGCAGGACAC
ATCAACAAGCCCCATTAAAAAGAAAAAGAAACCTGGCTTACTGAACAGTAACAATAAGGAGCAGTCAGAACTAAGACATGGTCCGTTTTA
CTATATGAAGCAGCCACTCACCACAGACCCTGTTGATGTTGTACCGCAGGATGGACGGAATGATTTCTACTGCTGGGTTTGTCACCGGGA
AGGCCAAGTCCTTTGCTGTGAGCTCTGTCCCCGGGTTTATCACGCTAAGTGTCTGAGACTGACATCGGAACCAGAGGGGGACTGGTTTTG
TCCTGAATGTGAGAAAATTACAGTAGCAGAATGCATCGAGACCCAGAGTAAAGCCATGACAATGCTCACCATTGAACAGTTATCCTACCT
GCTCAAGTTTGCCATTCAGAAAATGAAACAGCCAGGGACAGATGCATTCCAGAAGCCCGTTCCATTGGAACAGCACCCTGACTATGCGGA
ATACATCTTCCATCCAATGGACCTTTGTACATTGGAAAAGAATGCGAAAAAGAAAATGTATGGCTGCACAGAAGCCTTCCTGGCTGATGC
AAAGTGGATTTTGCACAACTGCATCATTTATAATGGGGGAAATCACAAATTGACGCAAATAGCGAAAGTAGTCATCAAAATCTGTGAACA
TGAGATGAATGAAATCGAAGTATGTCCAGAATGTTATCTAGCTGCTTGCCAAAAACGAGATAACTGGTTTTGTGAGCCTTGTAGCAATCC
ACATCCTTTGGTCTGGGCCAAACTGAAGGGGTTTCCATTCTGGCCTGCAAAAGCTCTAAGGGATAAAGACGGGCAGGTCGATGCCCGATT
CTTTGGACAACATGACAGGGCCTGGGTTCCAATAAATAATTGCTACCTCATGTCTAAAGAAATTCCTTTTTCTGTGAAAAAGACTAAGAG
CATCTTCAACAGTGCCATGCAAGAGATGGAGGTTTACGTGGAGAACATCCGCAGGAAGTTTGGGGTTTTTAATTACTCTCCATTTAGGAC
ACCCTACACACCCAACAGCCAGTATCAAATGCTGCTCGATCCCACCAACCCCAGCGCCGGCACTGCCAAGATAGACAAGCAGGAGAAGGT
CAAGCTCAACTTTGACATGACGGCATCCCCCAAGATCCTGATGAGCAAGCCTGTGCTGAGTGGGGGCACAGGCCGCCGGATTTCCTTGTC
GGATATGCCGCGCTCCCCCATGAGCACAAACTCTTCTGTGCACACGGGCTCCGACGTGGAGCAGGATGCTGAGAAGAAGGCCACGTCGAG
CCACTTCAGTGCGAGCGAGGAGTCCATGGACTTCCTGGATAAGAGCACAGCTTCACCAGCCTCCACCAAGACGGGACAAGCAGGGAGTTT
ATCCGGCAGCCCAAAGCCCTTCTCTCCTCAACTGTCAGCTCCTATCACGACGAAAACGGACAAAACCTCCACCACCGGCAGCATCCTGAA
TCTTAACCTGGATCGAAGCAAAGCTGAGATGGATTTGAAGGAGCTGAGCGAGTCGGTCCAGCAACAGTCCACCCCTGTTCCTCTCATCTC
TCCCAAGCGCCAGATTCGTAGCAGGTTCCAGCTGAATCTTGACAAGACCATAGAGAGTTGCAAAGCACAATTAGGCATAAATGAAATCTC
GGAAGATGTCTATACGGCCGTAGAGCACAGCGATTCGGAGGATTCTGAGAAGTCAGATAGTAGCGATAGTGAGTATATCAGTGATGATGA
GCAGAAGTCTAAGAACGAGCCAGAAGACACAGAGGACAAAGAAGGTTGTCAGATGGACAAAGAGCCATCTGCTGTTAAAAAAAAGCCCAA
GCCTACAAACCCAGTGGAGATTAAAGAGGAGCTGAAAAGCACGTCACCAGCCAGCGAGAAGGCAGACCCTGGAGCAGTCAAGGACAAGGC
CAGCCCTGAGCCTGAGAAGGACTTTTCCGAAAAGGCAAAACCTTCACCTCACCCCATAAAGGATAAACTGAAGGGAAAAGATGAGACGGA
TTCCCCAACAGTCCATTTGGGCCTGGACTCTGATTCAGAGAGCGAACTTGTCATAGATTTAGGAGAAGACCATTCTGGGCGGGAGGGTCG
AAAAAATAAGAAGGAACCCAAAGAACCATCTCCCAAACAGGATGTTGTAGGTAAAACTCCACCATCCACGACGGTGGGCAGCCATTCTCC
CCCGGAAACACCGGTGCTCACCCGCTCTTCCGCCCAAACTTCCGCGGCTGGCGCCACAGCCACCACCAGCACGTCCTCCACGGTCACCGT
CACGGCCCCGGCCCCCGCCGCCACAGGAAGCCCAGTGAAAAAGCAGAGGCCGCTTTTACCGAAGGAGACTGCCCCGGCCGTGCAGCGGGT
CGTGTGGAACTCATCAAGTAAGTTTCAAACGTCCTCCCAAAAGTGGCACATGCAGAAGATGCAGCGTCAGCAGCAGCAGCAGCAGCAGCA
AAACCAGCAGCAGCAGCCTCAGTCTTCCCAGGGGACGAGATATCAGACCAGACAGGCTGTGAAAGCTGTCCAGCAGAAGGAGATCACACA
GAGCCCATCCACGTCCACCATCACCCTGGTGACCAGCACACAGTCATCGCCCCTGGTCACCAGCTCGGGGTCCATGAGCACCCTTGTGTC
CTCAGTCAACGCTGACCTGCCCATCGCCACTGCCTCAGCTGATGTCGCCGCTGATATTGCCAAGTACACTAGCAAAATGATGGATGCAAT
AAAAGGAACAATGACAGAAATATACAACGATCTTTCTAAAAACACTACTGGAAGCACAATAGCTGAGATTCGCAGGCTGAGGATCGAGAT
AGAGAAGCTCCAGTGGCTGCACCAGCAAGAGCTCTCCGAAATGAAACACAACTTAGAGCTGACCATGGCGGAGATGCGGCAGAGCCTGGA
GCAGGAGCGGGACCGGCTCATCGCCGAGGTGAAGAAGCAGCTGGAGTTGGAGAAGCAGCAGGCGGTGGATGAGACCAAGAAGAAGCAGTG
GTGCGCCAACTGCAAGAAGGAGGCCATCTTTTACTGCTGTTGGAACACTAGCTACTGTGACTACCCCTGCCAGCAAGCCCACTGGCCTGA
GCACATGAAGTCCTGCACCCAGTCAGCTACTGCTCCTCAGCAGGAAGCGGATGCTGAGGTGAACACAGAAACACTAAATAAGTCCTCCCA
GGGGAGCTCCTCGAGCACACAATCAGCACCTTCAGAAACGGCCAGCGCCTCCAAAGAGAAGGAGACGTCAGCTGAGAAAAGCAAGGAGAG
TGGCTCGCCTCCCAATATCACTGCAGGCCACACCAGCCACCCCAGCTACACTCTCTGCATCGTCTTCTGCAGGGGGCTCCAGGACCCCTG
CCATGTCGTCATCTTCTTCATCGAGGGTCTTGCTGCGGCAGCAGCTAATGCGGGCCCAGGCGCAGGAGCAGGAGAGGCGTGAGCGTCGGG
AACAGGCCGCCGCGGCTCCCTTCCCCAGTCCTGCACCTGCCTCTCCTGCCATCTCTGTGGTTGGCGTCTCTGCTGGGGGCCACACATTGA
GCCGTCCACCCCCTGCTCAGGTGCCCAGGGAGGTGCTCAAGGTGCAGACCCATCTGGAGAACCCAACGCGCTACCACCTGCAGCAGGCGC
GCCGGCAGCAGGTGAAACAGTACCTGTCCACCACACTCGGGCCCAAGCTGGCTTCCCAGGCCCTCACCCCACCGCCGGGGCCCGCAAGTG
CCCAGCCACTGCCTGCCCCTGAGGCTGCCCACACTACCGGCCCCACAGGCAGTGCGCCCAACAGCCCCATGGCGCTGCTCACCATCGGGT
CCAGCTCAGAGAAGGAGATTGATGATGTCATTGATGAGATCATCAGCCTGGAGTCCAGTTACAATGATGAAATGCTCAGCTATCTGCCCG
GAGGCACCACAGGACTGCAGCTCCCCAGCACGCTGCCTGTGTCAGGGAATCTGCTTGATGTGTACAGTAGTCAAGGCGTGGCCACACCAG
CCATCACTGTCAGCAACTCCTGCCCAGCTGAGCTGCCCAACATCAAACGGGAGATCTCTGAGACCGAGGCAAAGGCCCTTTTGAAGGAAC
GGCAGAAGAAAGACAATCACAACCTAATTGAGCGTCGCAGGCGATTCAACATTAACGACAGGATCAAGGAACTGGGCACTCTCATCCCTA
AGTCCAGTGACCCGGAGATGCGCTGGAACAAGGGCACCATCCTGAAGGCCTCTGTGGATTATATCCGCAAGCTGCAGAAGGAGCAGCAGC
GCTCCAAAGACCTGGAGAGCCGGCAGCGATCCCTGGAGCAGGCCAACCGCAGCCTGCAGCTCCGAATTCAGGAACTAGAACTGCAGGCCC
AGATCCATGGCCTGCCAGTACCTCCCACTCCAGGGCTGCTTTCCTTGGCCACGACTTCGGCTTCTGACAGCCTCAAGCCAGAGCAGCTGG
ACATTGAGGAGGAGGGCAGGCCAGGCGCAGCAACGTTCCATGTAGGGGGGGGACCTGCCCAGAATGCTCCCCATCAGCAGCCCCCTGCAC
CGCCCTCAGATGCCCTTCTGGACCTGCACTTTCCCAGCGACCACCTGGGGGACCTGGGAGACCCCTTCCACCTGGGGCTGGAGGACATTC
TGATGGAGGAGGAGGAGGGGGTGGTGGGAGGACTGTCGGGGGGTGCCCTGTCCCCACTGCGGGCTGCCTCCGATCCCCTGCTCTCTTCAG
TGTCCCCTGCTGTCTCCAAGGCCAGCAGCCGCCGCAGCAGCTTCAGCATGGAAGAGGAGTCCTGATCAGGCCTCACCCCTCCCCTGGGAC
TTTCCCACCCAGGAAAGGAGGACCAGTCAGGATGAGGCCCCGCCTTTTCCCCCACCCTCCCATGAGACTGCCCTGCCCAGGTATCCTGGG
GGAAGAGGAGATGTGATCAGGCCCCACCCCTGTAATCAGGCAAGGAGGAGGAGTCAGATGAGGCCCTGCACCTTCCCCAAAGGAACCGCC
CAGTGCAGGTATTTCAGAAGGAGAAGGCTGGAGAAGGACATGAGATCAGGGCCTGCCCCCTGGGGATCACAGCCTCACCCCTGCCCCTGT
GGGACTCATCCTTGCCCAGGTGAGGGAAGGAGACAGGATGAGGTCTCGACCCTGTCCCCTAGGGACTGTCCTAGCCAGGTCTCCTGGGAA
AGGGAGATGTCAGGATGTTGCTCCATCCTTTGTCTTGGAACCACCAGTCTAGTCCGTCCTGGCACAGAAGAGGAGTCAAGTAATGGAGGT
CCCAGCCCTGGGGGTTTAAGCTCTGCCCCTTCCCCATGAACCCTGCCCTGCTCTGCCCAGGCAAGGAACAGAAGTGAGGATGAGACCCAG
CCCCTTCCCCTGGGAACTCTCCTGGCCTTCTAGGAATGGAGGAGCCAGGCCCCACCCCTTCCCTATAGGAACAGCCCAGCACAGGTATTT
CAGGTGTGAAAGAATCAGTAGGACCAGGCCACCGCTAGTGCTTGTGGAGATCACAGCCCCACCCTTGTCCCTCAGCAACATCCCATCTAA
GCATTCCACACTGCAGGGAGGAGTGGTACTTAAGCTCCCCTGCCTTAACCTGGGACCAACCTGACCTAACCTAGGAGGGCTCTGAGCCAA
CCTTGCTCTTGGGGAAGGGGACAGATTATGAAATTTCATGGATGAATTTTCCAGACCTATATCTGGAGTGAGAGGCCCCCACCCTTGGGC
AGAGTCCTGCCTTCTTCCTTGAGGGGCAGTTTGGGAAGGTGATGGGTATTAGTGGGGGACTGAGTTCAGGTTACCAGAACCAGTACCTCA
GTATTCTTTTTCAACATGTAGGGCAAGAGGATGAAGGAAGGGGCTATCCTGGGACCTCCCCAGCCCAGGAAAAACTGGAAGCCTTCCCCC
AGCAAGGCAGAAGCTTGGAGGAGGGTTGTAAAAGCATATTGTACCCCCTCATTTGTTTATCTGATTTTTTTATTGCTCCGCATACTGAGA
ATCTAGGCCACCCCAACCTCTGTTCCCCACCCAGTTCTTCATTTGGAGGAATCACCCCATTTCAGAGTTATCAAGAGACACTCCCCCCTC
CATTCCCACCCCTCATACCTACACCCAAGGTTGTCAGCTTTGGATTGCTGGGGCCAGGCCCCATGGAGGGTATACTGAGGGGTCTATAGG

>In-frame_ENST00000355972_ENST00000315869_TCGA-B5-A3FB-01A_ZMYND8_chr20_45849965_-_TFE3_chrX_48896935_length(amino acids)=1188AA_start in transcript=115_stop in transcript=3681
MAEEEIKTEQEVVEGMDISTRSKDPGSAERTAQKRKFPSPPHSSNGHSPQDTSTSPIKKKKKPGLLNSNNKEQSELRHGPFYYMKQPLTT
DPVDVVPQDGRNDFYCWVCHREGQVLCCELCPRVYHAKCLRLTSEPEGDWFCPECEKITVAECIETQSKAMTMLTIEQLSYLLKFAIQKM
KQPGTDAFQKPVPLEQHPDYAEYIFHPMDLCTLEKNAKKKMYGCTEAFLADAKWILHNCIIYNGGNHKLTQIAKVVIKICEHEMNEIEVC
PECYLAACQKRDNWFCEPCSNPHPLVWAKLKGFPFWPAKALRDKDGQVDARFFGQHDRAWVPINNCYLMSKEIPFSVKKTKSIFNSAMQE
MEVYVENIRRKFGVFNYSPFRTPYTPNSQYQMLLDPTNPSAGTAKIDKQEKVKLNFDMTASPKILMSKPVLSGGTGRRISLSDMPRSPMS
TNSSVHTGSDVEQDAEKKATSSHFSASEESMDFLDKSTASPASTKTGQAGSLSGSPKPFSPQLSAPITTKTDKTSTTGSILNLNLDRSKA
EMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNLDKTIESCKAQLGINEISEDVYTAVEHSDSEDSEKSDSSDSEYISDDEQKSKNEPE
DTEDKEGCQMDKEPSAVKKKPKPTNPVEIKEELKSTSPASEKADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKDETDSPTVHLGL
DSDSESELVIDLGEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSPPETPVLTRSSAQTSAAGATATTSTSSTVTVTAPAPAAT
GSPVKKQRPLLPKETAPAVQRVVWNSSSKFQTSSQKWHMQKMQRQQQQQQQQNQQQQPQSSQGTRYQTRQAVKAVQQKEITQSPSTSTIT
LVTSTQSSPLVTSSGSMSTLVSSVNADLPIATASADVAADIAKYTSKMMDAIKGTMTEIYNDLSKNTTGSTIAEIRRLRIEIEKLQWLHQ
QELSEMKHNLELTMAEMRQSLEQERDRLIAEVKKQLELEKQQAVDETKKKQWCANCKKEAIFYCCWNTSYCDYPCQQAHWPEHMKSCTQS
ATAPQQEADAEVNTETLNKSSQGSSSSTQSAPSETASASKEKETSAEKSKESGSPPNITAGHTSHPSYTLCIVFCRGLQDPCHVVIFFIE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ZMYND8-TFE3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000262975	-	21	24	75_406	1073.0	1169.0	histone H3K14ac
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000311275	-	20	22	75_406	1119.0	1187.0	histone H3K14ac
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000352431	-	20	22	75_406	1093.0	1161.0	histone H3K14ac
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000355972	-	21	24	75_406	1119.0	1215.0	histone H3K14ac
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000360911	-	20	22	75_406	1068.0	1136.0	histone H3K14ac
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000461685	-	20	23	75_406	1093.0	1189.0	histone H3K14ac
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000471951	-	20	23	75_406	1139.0	1235.0	histone H3K14ac
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000262975	-	21	24	75_268	1073.0	1169.0	histone H3K4me0
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000311275	-	20	22	75_268	1119.0	1187.0	histone H3K4me0
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000352431	-	20	22	75_268	1093.0	1161.0	histone H3K4me0
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000355972	-	21	24	75_268	1119.0	1215.0	histone H3K4me0
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000360911	-	20	22	75_268	1068.0	1136.0	histone H3K4me0
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000461685	-	20	23	75_268	1093.0	1189.0	histone H3K4me0
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000471951	-	20	23	75_268	1139.0	1235.0	histone H3K4me0

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000262975	-	21	24	1147_1186	1073.0	1169.0	PRKCB1
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000311275	-	20	22	1147_1186	1119.0	1187.0	PRKCB1
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000352431	-	20	22	1147_1186	1093.0	1161.0	PRKCB1
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000355972	-	21	24	1147_1186	1119.0	1215.0	PRKCB1
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000360911	-	20	22	1147_1186	1068.0	1136.0	PRKCB1
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000461685	-	20	23	1147_1186	1093.0	1189.0	PRKCB1
Hgene	ZMYND8	chr20:45849965	chrX:48896935	ENST00000471951	-	20	23	1147_1186	1139.0	1235.0	PRKCB1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ZMYND8-TFE3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ZMYND8-TFE3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	TFE3	C4518356	MiT family translocation renal cell carcinoma	2	ORPHANET
Tgene	TFE3	C0206657	Alveolar Soft Part Sarcoma	1	ORPHANET
Tgene	TFE3	C0206732	Epithelioid hemangioendothelioma	1	ORPHANET