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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF160-PRKAR1A (FusionGDB2 ID:100862)

Fusion Gene Summary for ZNF160-PRKAR1A

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF160-PRKAR1A
Fusion gene ID: 100862
HgeneTgene
Gene symbol

ZNF160

PRKAR1A

Gene ID

90338

5573

Gene namezinc finger protein 160protein kinase cAMP-dependent type I regulatory subunit alpha
SynonymsF11|HKr18|HZF5|KR18ACRDYS1|ADOHR|CAR|CNC|CNC1|PKR1|PPNAD1|PRKAR1|TSE1
Cytomap

19q13.41-q13.42

17q24.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 160KRAB zinc finger protein KR18zinc finger protein 5zinc finger protein HZF5zinc finger protein Kr18cAMP-dependent protein kinase type I-alpha regulatory subunitCarney complex type 1cAMP-dependent protein kinase regulatory subunit RIalphacAMP-dependent protein kinase type I-alpha regulatory chainepididymis secretory sperm binding proteinprotein kin
Modification date2020031320200329
UniProtAcc.

P10644

Ensembl transtripts involved in fusion geneENST00000599056, ENST00000418871, 
ENST00000429604, ENST00000601421, 
ENST00000355147, ENST00000599729, 
ENST00000358598, ENST00000392711, 
ENST00000589228, ENST00000536854, 
ENST00000586397, ENST00000588188, 
Fusion gene scores* DoF score7 X 8 X 4=22413 X 16 X 6=1248
# samples 717
** MAII scorelog2(7/224*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1248*10)=-2.87601128272455
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF160 [Title/Abstract] AND PRKAR1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF160(53594665)-PRKAR1A(66521894), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRKAR1A

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

21812984


check buttonFusion gene breakpoints across ZNF160 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PRKAR1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A9FRZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
ChimerDB4ESCATCGA-LN-A9FRZNF160chr19

53594665

-PRKAR1Achr17

66521894

+


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Fusion Gene ORF analysis for ZNF160-PRKAR1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000599056ENST00000358598ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000599056ENST00000392711ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000599056ENST00000589228ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000599056ENST00000536854ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000599056ENST00000586397ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000599056ENST00000588188ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000418871ENST00000358598ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000418871ENST00000392711ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000418871ENST00000589228ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000418871ENST00000536854ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000418871ENST00000586397ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000418871ENST00000588188ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000429604ENST00000358598ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000429604ENST00000392711ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000429604ENST00000589228ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000429604ENST00000536854ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000429604ENST00000586397ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000429604ENST00000588188ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000601421ENST00000358598ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000601421ENST00000392711ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000601421ENST00000589228ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000601421ENST00000536854ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000601421ENST00000586397ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000601421ENST00000588188ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000355147ENST00000358598ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000355147ENST00000392711ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000355147ENST00000589228ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000355147ENST00000536854ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000355147ENST00000586397ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
5UTR-3CDSENST00000355147ENST00000588188ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000599729ENST00000358598ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000599729ENST00000392711ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000599729ENST00000589228ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000599729ENST00000536854ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000599729ENST00000586397ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+
intron-3CDSENST00000599729ENST00000588188ZNF160chr19

53594665

-PRKAR1Achr17

66521894

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZNF160-PRKAR1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZNF160chr1953594665-PRKAR1Achr1766521894+0.0667201360.9332799
ZNF160chr1953594665-PRKAR1Achr1766521894+0.0667201360.9332799

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF160-PRKAR1A


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.PRKAR1A

P10644

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. {ECO:0000269|PubMed:16491121, ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:26405036}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZNF160-PRKAR1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZNF160-PRKAR1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF160-PRKAR1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF160-PRKAR1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZNF160C0024623Malignant neoplasm of stomach1CTD_human
HgeneZNF160C0033578Prostatic Neoplasms1CTD_human
HgeneZNF160C0038356Stomach Neoplasms1CTD_human
HgeneZNF160C0376358Malignant neoplasm of prostate1CTD_human
HgeneZNF160C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgenePRKAR1AC2607929Carney Complex, Type 110CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgenePRKAR1AC3276228ACRODYSOSTOSIS 1 WITH OR WITHOUT HORMONE RESISTANCE8CTD_human;GENOMICS_ENGLAND;UNIPROT
TgenePRKAR1AC0406810Carney Complex6CLINGEN;CTD_human;GENOMICS_ENGLAND
TgenePRKAR1AC0220659Acrodysostosis4CTD_human;GENOMICS_ENGLAND;ORPHANET
TgenePRKAR1AC0010481Cushing Syndrome2CTD_human
TgenePRKAR1AC1864846PIGMENTED NODULAR ADRENOCORTICAL DISEASE, PRIMARY, 1 (disorder)2CTD_human;GENOMICS_ENGLAND
TgenePRKAR1AC0001627Congenital adrenal hyperplasia1CTD_human
TgenePRKAR1AC0002170Alopecia1CTD_human
TgenePRKAR1AC0020456Hyperglycemia1CTD_human
TgenePRKAR1AC0021655Insulin Resistance1CTD_human
TgenePRKAR1AC0023487Acute Promyelocytic Leukemia1CTD_human;ORPHANET
TgenePRKAR1AC0026846Muscular Atrophy1CTD_human
TgenePRKAR1AC0028754Obesity1CTD_human
TgenePRKAR1AC0086873Pseudopelade1CTD_human
TgenePRKAR1AC0162311Androgenetic Alopecia1CTD_human
TgenePRKAR1AC0263477Female pattern alopecia (disorder)1CTD_human
TgenePRKAR1AC0270948Neurogenic Muscular Atrophy1CTD_human
TgenePRKAR1AC0920563Insulin Sensitivity1CTD_human
TgenePRKAR1AC1850635Atrial myxoma, familial1CTD_human;ORPHANET
TgenePRKAR1AC1854540Carney Complex, Type 21CTD_human
TgenePRKAR1AC1855520Hyperglycemia, Postprandial1CTD_human
TgenePRKAR1AC3553250ACRODYSOSTOSIS 2 WITH OR WITHOUT HORMONE RESISTANCE1CTD_human
TgenePRKAR1AC3887949Apparent mineralocorticoid excess1CTD_human
TgenePRKAR1AC4083212Alopecia, Male Pattern1CTD_human
TgenePRKAR1AC4304832Primary pigmented nodular adrenocortical disease1ORPHANET
TgenePRKAR1AC4721502Peripheral dysostosis1CTD_human