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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF423-TNFSF10 (FusionGDB2 ID:101359)

Fusion Gene Summary for ZNF423-TNFSF10

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF423-TNFSF10
Fusion gene ID: 101359
HgeneTgene
Gene symbol

ZNF423

TNFSF10

Gene ID

23090

8743

Gene namezinc finger protein 423TNF superfamily member 10
SynonymsEbfaz|JBTS19|NPHP14|OAZ|Roaz|ZFP423|Zfp104|hOAZAPO2L|Apo-2L|CD253|TL2|TNLG6A|TRAIL
Cytomap

16q12.1

3q26.31

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 423OLF-1/EBF associated zinc fingerSmad- and Olf-interacting zinc finger proteinearly B-cell factor associated zinc finger proteinolf1/EBF-associated zinc finger proteintumor necrosis factor ligand superfamily member 10Apo-2 ligandTNF-related apoptosis inducing ligand TRAILchemokine tumor necrosis factor ligand superfamily member 10tumor necrosis factor (ligand) family, member 10tumor necrosis factor (ligand) superf
Modification date2020032920200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000561648, ENST00000563137, 
ENST00000562871, ENST00000262383, 
ENST00000535559, ENST00000567169, 
ENST00000562520, 		ENST00000241261, 
ENST00000420541, 
Fusion gene scores* DoF score5 X 6 X 3=905 X 4 X 4=80
# samples 66
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF423 [Title/Abstract] AND TNFSF10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF423(49889646)-TNFSF10(172232788), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneZNF423

GO:0045892

negative regulation of transcription, DNA-templated

10660046

HgeneZNF423

GO:0045893

positive regulation of transcription, DNA-templated

10660046

TgeneTNFSF10

GO:0043065

positive regulation of apoptotic process

21525171

TgeneTNFSF10

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

21459798|21525171|22266862

TgeneTNFSF10

GO:0090200

positive regulation of release of cytochrome c from mitochondria

22266862

TgeneTNFSF10

GO:2001238

positive regulation of extrinsic apoptotic signaling pathway

20097879|21525171|22266862


check buttonFusion gene breakpoints across ZNF423 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across TNFSF10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-NF-A5CP-01AZNF423chr16

49889646

-TNFSF10chr3

172232788

-


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Fusion Gene ORF analysis for ZNF423-TNFSF10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000561648ENST00000241261ZNF423chr16

49889646

-TNFSF10chr3

172232788

-
intron-3CDSENST00000561648ENST00000420541ZNF423chr16

49889646

-TNFSF10chr3

172232788

-
5UTR-3CDSENST00000563137ENST00000241261ZNF423chr16

49889646

-TNFSF10chr3

172232788

-
5UTR-3CDSENST00000563137ENST00000420541ZNF423chr16

49889646

-TNFSF10chr3

172232788

-
intron-3CDSENST00000562871ENST00000241261ZNF423chr16

49889646

-TNFSF10chr3

172232788

-
intron-3CDSENST00000562871ENST00000420541ZNF423chr16

49889646

-TNFSF10chr3

172232788

-
intron-3CDSENST00000262383ENST00000241261ZNF423chr16

49889646

-TNFSF10chr3

172232788

-
intron-3CDSENST00000262383ENST00000420541ZNF423chr16

49889646

-TNFSF10chr3

172232788

-
intron-3CDSENST00000535559ENST00000241261ZNF423chr16

49889646

-TNFSF10chr3

172232788

-
intron-3CDSENST00000535559ENST00000420541ZNF423chr16

49889646

-TNFSF10chr3

172232788

-
intron-3CDSENST00000567169ENST00000241261ZNF423chr16

49889646

-TNFSF10chr3

172232788

-
intron-3CDSENST00000567169ENST00000420541ZNF423chr16

49889646

-TNFSF10chr3

172232788

-
intron-3CDSENST00000562520ENST00000241261ZNF423chr16

49889646

-TNFSF10chr3

172232788

-
intron-3CDSENST00000562520ENST00000420541ZNF423chr16

49889646

-TNFSF10chr3

172232788

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZNF423-TNFSF10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF423-TNFSF10


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZNF423-TNFSF10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZNF423-TNFSF10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF423-TNFSF10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF423-TNFSF10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneZNF423C0236733Amphetamine-Related Disorders1CTD_human
HgeneZNF423C0236804Amphetamine Addiction1CTD_human
HgeneZNF423C0236807Amphetamine Abuse1CTD_human
HgeneZNF423C1855675Arima syndrome1GENOMICS_ENGLAND;ORPHANET
HgeneZNF423C1865872NEPHRONOPHTHISIS 21ORPHANET
HgeneZNF423C3539071NEPHRONOPHTHISIS 141CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneZNF423C3553846JOUBERT SYNDROME 191GENOMICS_ENGLAND
TgeneTNFSF10C0033578Prostatic Neoplasms4CTD_human
TgeneTNFSF10C0376358Malignant neoplasm of prostate4CTD_human
TgeneTNFSF10C0017638Glioma2CTD_human
TgeneTNFSF10C0027659Neoplasms, Experimental2CTD_human
TgeneTNFSF10C0027686Pathologic Neovascularization2CTD_human
TgeneTNFSF10C0259783mixed gliomas2CTD_human
TgeneTNFSF10C0555198Malignant Glioma2CTD_human
TgeneTNFSF10C0000786Spontaneous abortion1CTD_human
TgeneTNFSF10C0000822Abortion, Tubal1CTD_human
TgeneTNFSF10C0006142Malignant neoplasm of breast1CTD_human
TgeneTNFSF10C0007102Malignant tumor of colon1CTD_human
TgeneTNFSF10C0007134Renal Cell Carcinoma1CTD_human
TgeneTNFSF10C0009375Colonic Neoplasms1CTD_human
TgeneTNFSF10C0009402Colorectal Carcinoma1CTD_human
TgeneTNFSF10C0009404Colorectal Neoplasms1CTD_human
TgeneTNFSF10C0014170Endometrial Neoplasms1CTD_human
TgeneTNFSF10C0017636Glioblastoma1CTD_human
TgeneTNFSF10C0021400Influenza1CTD_human
TgeneTNFSF10C0022665Kidney Neoplasm1CTD_human
TgeneTNFSF10C0023418leukemia1CTD_human
TgeneTNFSF10C0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneTNFSF10C0023903Liver neoplasms1CTD_human
TgeneTNFSF10C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneTNFSF10C0026998Acute Myeloid Leukemia, M11CTD_human
TgeneTNFSF10C0027627Neoplasm Metastasis1CTD_human
TgeneTNFSF10C0027819Neuroblastoma1CTD_human
TgeneTNFSF10C0030297Pancreatic Neoplasm1CTD_human
TgeneTNFSF10C0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneTNFSF10C0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneTNFSF10C0334588Giant Cell Glioblastoma1CTD_human
TgeneTNFSF10C0345904Malignant neoplasm of liver1CTD_human
TgeneTNFSF10C0346647Malignant neoplasm of pancreas1CTD_human
TgeneTNFSF10C0476089Endometrial Carcinoma1CTD_human
TgeneTNFSF10C0678222Breast Carcinoma1CTD_human
TgeneTNFSF10C0740457Malignant neoplasm of kidney1CTD_human
TgeneTNFSF10C0919267ovarian neoplasm1CTD_human
TgeneTNFSF10C1140680Malignant neoplasm of ovary1CTD_human
TgeneTNFSF10C1257931Mammary Neoplasms, Human1CTD_human
TgeneTNFSF10C1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneTNFSF10C1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneTNFSF10C1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneTNFSF10C1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneTNFSF10C1458155Mammary Neoplasms1CTD_human
TgeneTNFSF10C1621958Glioblastoma Multiforme1CTD_human
TgeneTNFSF10C1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneTNFSF10C2239176Liver carcinoma1CTD_human
TgeneTNFSF10C3830362Early Pregnancy Loss1CTD_human
TgeneTNFSF10C4552766Miscarriage1CTD_human
TgeneTNFSF10C4704874Mammary Carcinoma, Human1CTD_human