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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZNF462-VEGFA (FusionGDB2 ID:101474)

Fusion Gene Summary for ZNF462-VEGFA

Fusion gene summary

Fusion gene information	Fusion gene name: ZNF462-VEGFA
	Fusion gene ID: 101474
		Hgene	Tgene
	Gene symbol	ZNF462	VEGFA
	Gene ID	58499	7422
	Gene name	zinc finger protein 462	vascular endothelial growth factor A
	Synonyms	WSKA\|ZFPIP\|Zfp462	MVCD1\|VEGF\|VPF
	Cytomap	9q31.2	6p21.1
	Type of gene	protein-coding	protein-coding
	Description	zinc finger protein 462zinc finger PBX1-interacting protein	vascular endothelial growth factor Avascular endothelial growth factor A121vascular endothelial growth factor A165vascular permeability factor
	Modification date	20200313	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000457913, ENST00000277225, ENST00000441147, ENST00000542028, ENST00000497489,	ENST00000372067, ENST00000417285, ENST00000324450, ENST00000413642, ENST00000372055, ENST00000482630, ENST00000425836, ENST00000372064, ENST00000372077, ENST00000520948, ENST00000523873, ENST00000523950, ENST00000518689, ENST00000523125, ENST00000457104, ENST00000518824, ENST00000230480,
Fusion gene scores	* DoF score	7 X 5 X 5=175	10 X 9 X 5=450
	# samples	7	13
	** MAII score	log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/450*10)=-1.79141337818858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNF462 [Title/Abstract] AND VEGFA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZNF462(109625636)-VEGFA(43742078), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	VEGFA	GO:0000122	negative regulation of transcription by RNA polymerase II	18093989
Tgene	VEGFA	GO:0001525	angiogenesis	11427521\|21771332
Tgene	VEGFA	GO:0001666	response to hypoxia	16490744
Tgene	VEGFA	GO:0001934	positive regulation of protein phosphorylation	18386220\|19033661
Tgene	VEGFA	GO:0001938	positive regulation of endothelial cell proliferation	9202027\|10022831\|12714610\|16489009\|18386220\|18577655\|20497126
Tgene	VEGFA	GO:0002042	cell migration involved in sprouting angiogenesis	18059339\|20660291
Tgene	VEGFA	GO:0002092	positive regulation of receptor internalization	20660291
Tgene	VEGFA	GO:0008284	positive regulation of cell proliferation	7929439
Tgene	VEGFA	GO:0008360	regulation of cell shape	7929439\|10527820
Tgene	VEGFA	GO:0010595	positive regulation of endothelial cell migration	10022831\|19033661
Tgene	VEGFA	GO:0010628	positive regulation of gene expression	18386220
Tgene	VEGFA	GO:0010629	negative regulation of gene expression	28977001
Tgene	VEGFA	GO:0010749	regulation of nitric oxide mediated signal transduction	16150726
Tgene	VEGFA	GO:0030224	monocyte differentiation	21149635
Tgene	VEGFA	GO:0030225	macrophage differentiation	21149635
Tgene	VEGFA	GO:0030335	positive regulation of cell migration	7929439\|17470632
Tgene	VEGFA	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	1312256\|7929439
Tgene	VEGFA	GO:0031334	positive regulation of protein complex assembly	16489009\|19033661
Tgene	VEGFA	GO:0031954	positive regulation of protein autophosphorylation	20497126
Tgene	VEGFA	GO:0032147	activation of protein kinase activity	18059339\|20497126
Tgene	VEGFA	GO:0032793	positive regulation of CREB transcription factor activity	20497126
Tgene	VEGFA	GO:0033138	positive regulation of peptidyl-serine phosphorylation	18440775\|20497126
Tgene	VEGFA	GO:0035148	tube formation	19033661
Tgene	VEGFA	GO:0035767	endothelial cell chemotaxis	18440775
Tgene	VEGFA	GO:0035924	cellular response to vascular endothelial growth factor stimulus	18440775\|20497126
Tgene	VEGFA	GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway	18440775\|20497126\|21245381
Tgene	VEGFA	GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	17470632
Tgene	VEGFA	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	19390056
Tgene	VEGFA	GO:0043117	positive regulation of vascular permeability	26598555
Tgene	VEGFA	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	18386220
Tgene	VEGFA	GO:0043406	positive regulation of MAP kinase activity	18440775
Tgene	VEGFA	GO:0043536	positive regulation of blood vessel endothelial cell migration	9202027\|18440775\|20497126
Tgene	VEGFA	GO:0045766	positive regulation of angiogenesis	18440775\|18577655\|19033661\|20497126
Tgene	VEGFA	GO:0045785	positive regulation of cell adhesion	19674970
Tgene	VEGFA	GO:0045944	positive regulation of transcription by RNA polymerase II	18059339
Tgene	VEGFA	GO:0048010	vascular endothelial growth factor receptor signaling pathway	21245381
Tgene	VEGFA	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	10022831\|16489009\|20048167\|21245381\|26598555
Tgene	VEGFA	GO:0050918	positive chemotaxis	20497126
Tgene	VEGFA	GO:0050927	positive regulation of positive chemotaxis	7929439\|12744932
Tgene	VEGFA	GO:0051272	positive regulation of cellular component movement	10527820\|12744932
Tgene	VEGFA	GO:0051894	positive regulation of focal adhesion assembly	16489009
Tgene	VEGFA	GO:0071456	cellular response to hypoxia	10575000
Tgene	VEGFA	GO:0090037	positive regulation of protein kinase C signaling	18059339
Tgene	VEGFA	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	20551324
Tgene	VEGFA	GO:0097533	cellular stress response to acid chemical	26299712
Tgene	VEGFA	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation	20660291
Tgene	VEGFA	GO:1900745	positive regulation of p38MAPK cascade	18386220
Tgene	VEGFA	GO:1901727	positive regulation of histone deacetylase activity	20497126
Tgene	VEGFA	GO:1903141	negative regulation of establishment of endothelial barrier	20048167
Tgene	VEGFA	GO:1903392	negative regulation of adherens junction organization	26598555
Tgene	VEGFA	GO:1903572	positive regulation of protein kinase D signaling	20497126
Tgene	VEGFA	GO:1903672	positive regulation of sprouting angiogenesis	26299712
Tgene	VEGFA	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin	26598555

Fusion gene breakpoints across ZNF462 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VEGFA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AR-A24Q-01A	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+

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Fusion Gene ORF analysis for ZNF462-VEGFA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000457913	ENST00000372067	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000417285	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000324450	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000413642	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000372055	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000482630	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000425836	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000372064	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000372077	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000520948	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000523873	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000523950	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000518689	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000523125	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000457104	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000457913	ENST00000518824	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-5UTR	ENST00000457913	ENST00000230480	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000372067	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000417285	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000324450	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000413642	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000372055	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000482630	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000425836	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000372064	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000372077	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000520948	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000523873	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000523950	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000518689	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000523125	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000457104	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-3CDS	ENST00000277225	ENST00000518824	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
5UTR-5UTR	ENST00000277225	ENST00000230480	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000372067	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000417285	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000324450	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000413642	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000372055	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000482630	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000425836	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000372064	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000372077	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000520948	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000523873	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000523950	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000518689	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000523125	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000457104	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000441147	ENST00000518824	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-5UTR	ENST00000441147	ENST00000230480	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000372067	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000417285	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000324450	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000413642	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000372055	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000482630	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000425836	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000372064	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000372077	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000520948	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000523873	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000523950	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000518689	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000523125	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000457104	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000542028	ENST00000518824	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-5UTR	ENST00000542028	ENST00000230480	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000372067	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000417285	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000324450	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000413642	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000372055	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000482630	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000425836	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000372064	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000372077	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000520948	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000523873	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000523950	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000518689	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000523125	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000457104	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-3CDS	ENST00000497489	ENST00000518824	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+
intron-5UTR	ENST00000497489	ENST00000230480	ZNF462	chr9	109625636	+	VEGFA	chr6	43742078	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ZNF462-VEGFA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ZNF462	chr9	109625636	+	VEGFA	chr6	43742077	+	0.016627347	0.9833726
ZNF462	chr9	109625636	+	VEGFA	chr6	43742077	+	0.016627347	0.9833726

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF462-VEGFA

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ZNF462-VEGFA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZNF462-VEGFA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ZNF462-VEGFA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ZNF462-VEGFA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ZNF462	C0004238	Atrial Fibrillation	1	CTD_human
Hgene	ZNF462	C0005745	Blepharoptosis	1	GENOMICS_ENGLAND
Hgene	ZNF462	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
Hgene	ZNF462	C0010278	Craniosynostosis	1	GENOMICS_ENGLAND
Hgene	ZNF462	C0033377	Ptosis	1	GENOMICS_ENGLAND
Hgene	ZNF462	C0235480	Paroxysmal atrial fibrillation	1	CTD_human
Hgene	ZNF462	C0557874	Global developmental delay	1	GENOMICS_ENGLAND
Hgene	ZNF462	C0856975	Autistic behavior	1	GENOMICS_ENGLAND
Hgene	ZNF462	C1857949	Prominent metopic ridge	1	GENOMICS_ENGLAND
Hgene	ZNF462	C2585653	Persistent atrial fibrillation	1	CTD_human
Hgene	ZNF462	C3468561	familial atrial fibrillation	1	CTD_human
Hgene	ZNF462	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
Tgene	VEGFA	C0011570	Mental Depression	5	PSYGENET
Tgene	VEGFA	C0011581	Depressive disorder	5	PSYGENET
Tgene	VEGFA	C0151744	Myocardial Ischemia	5	CTD_human
Tgene	VEGFA	C1269683	Major Depressive Disorder	5	PSYGENET
Tgene	VEGFA	C0033578	Prostatic Neoplasms	4	CTD_human
Tgene	VEGFA	C0376358	Malignant neoplasm of prostate	4	CTD_human
Tgene	VEGFA	C0004096	Asthma	3	CTD_human
Tgene	VEGFA	C0011884	Diabetic Retinopathy	3	CTD_human
Tgene	VEGFA	C0027627	Neoplasm Metastasis	3	CTD_human
Tgene	VEGFA	C0027659	Neoplasms, Experimental	3	CTD_human
Tgene	VEGFA	C0003865	Arthritis, Adjuvant-Induced	2	CTD_human
Tgene	VEGFA	C0005586	Bipolar Disorder	2	PSYGENET
Tgene	VEGFA	C0007137	Squamous cell carcinoma	2	CTD_human
Tgene	VEGFA	C0010054	Coronary Arteriosclerosis	2	CTD_human
Tgene	VEGFA	C0018801	Heart failure	2	CTD_human
Tgene	VEGFA	C0018802	Congestive heart failure	2	CTD_human
Tgene	VEGFA	C0022660	Kidney Failure, Acute	2	CTD_human
Tgene	VEGFA	C0023212	Left-Sided Heart Failure	2	CTD_human
Tgene	VEGFA	C0023893	Liver Cirrhosis, Experimental	2	CTD_human
Tgene	VEGFA	C0027686	Pathologic Neovascularization	2	CTD_human
Tgene	VEGFA	C0235527	Heart Failure, Right-Sided	2	CTD_human
Tgene	VEGFA	C0525045	Mood Disorders	2	PSYGENET
Tgene	VEGFA	C0971858	Arthritis, Collagen-Induced	2	CTD_human
Tgene	VEGFA	C0993582	Arthritis, Experimental	2	CTD_human
Tgene	VEGFA	C1565662	Acute Kidney Insufficiency	2	CTD_human
Tgene	VEGFA	C1956346	Coronary Artery Disease	2	CTD_human
Tgene	VEGFA	C1959583	Myocardial Failure	2	CTD_human
Tgene	VEGFA	C1961112	Heart Decompensation	2	CTD_human
Tgene	VEGFA	C2609414	Acute kidney injury	2	CTD_human
Tgene	VEGFA	C0001418	Adenocarcinoma	1	CTD_human
Tgene	VEGFA	C0002152	Alloxan Diabetes	1	CTD_human
Tgene	VEGFA	C0002395	Alzheimer's Disease	1	CTD_human
Tgene	VEGFA	C0003873	Rheumatoid Arthritis	1	CTD_human
Tgene	VEGFA	C0004153	Atherosclerosis	1	CTD_human
Tgene	VEGFA	C0006118	Brain Neoplasms	1	CTD_human
Tgene	VEGFA	C0006826	Malignant Neoplasms	1	CTD_human
Tgene	VEGFA	C0007102	Malignant tumor of colon	1	CTD_human
Tgene	VEGFA	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
Tgene	VEGFA	C0007873	Uterine Cervical Neoplasm	1	CTD_human
Tgene	VEGFA	C0008677	Bronchitis, Chronic	1	CTD_human
Tgene	VEGFA	C0009375	Colonic Neoplasms	1	CTD_human
Tgene	VEGFA	C0010398	Cruveilhier-Baumgarten Syndrome	1	CTD_human
Tgene	VEGFA	C0011265	Presenile dementia	1	CTD_human
Tgene	VEGFA	C0011616	Contact Dermatitis	1	CTD_human
Tgene	VEGFA	C0011853	Diabetes Mellitus, Experimental	1	CTD_human
Tgene	VEGFA	C0011881	Diabetic Nephropathy	1	CTD_human
Tgene	VEGFA	C0013366	Dyschondroplasias	1	CTD_human
Tgene	VEGFA	C0014170	Endometrial Neoplasms	1	CTD_human
Tgene	VEGFA	C0014556	Epilepsy, Temporal Lobe	1	CTD_human
Tgene	VEGFA	C0014558	Uncinate Epilepsy	1	CTD_human
Tgene	VEGFA	C0017636	Glioblastoma	1	CTD_human
Tgene	VEGFA	C0017667	Nodular glomerulosclerosis	1	CTD_human
Tgene	VEGFA	C0018671	Head and Neck Neoplasms	1	CTD_human
Tgene	VEGFA	C0018675	Head Neoplasms	1	CTD_human
Tgene	VEGFA	C0018798	Congenital Heart Defects	1	CTD_human
Tgene	VEGFA	C0018799	Heart Diseases	1	CTD_human
Tgene	VEGFA	C0018923	Hemangiosarcoma	1	CTD_human
Tgene	VEGFA	C0019193	Hepatitis, Toxic	1	CTD_human
Tgene	VEGFA	C0020541	Portal Hypertension	1	CTD_human
Tgene	VEGFA	C0021368	Inflammation	1	CTD_human
Tgene	VEGFA	C0023186	Learning Disorders	1	CTD_human
Tgene	VEGFA	C0023466	Leukemia, Monocytic, Chronic	1	CTD_human
Tgene	VEGFA	C0023470	Myeloid Leukemia	1	CTD_human
Tgene	VEGFA	C0023890	Liver Cirrhosis	1	CTD_human
Tgene	VEGFA	C0024115	Lung diseases	1	CTD_human
Tgene	VEGFA	C0024440	Macular Edema, Cystoid	1	CTD_human
Tgene	VEGFA	C0025237	Melnick-Needles Syndrome	1	CTD_human
Tgene	VEGFA	C0025261	Memory Disorders	1	CTD_human
Tgene	VEGFA	C0026760	Multiple Epiphyseal Dysplasia	1	CTD_human
Tgene	VEGFA	C0027055	Myocardial Reperfusion Injury	1	CTD_human
Tgene	VEGFA	C0027533	Neck Neoplasms	1	CTD_human
Tgene	VEGFA	C0027643	Neoplasm Recurrence, Local	1	CTD_human
Tgene	VEGFA	C0027651	Neoplasms	1	CTD_human
Tgene	VEGFA	C0029422	Osteochondrodysplasias	1	CTD_human
Tgene	VEGFA	C0029463	Osteosarcoma	1	CTD_human
Tgene	VEGFA	C0030246	Pustulosis of Palms and Soles	1	CTD_human
Tgene	VEGFA	C0032927	Precancerous Conditions	1	CTD_human
Tgene	VEGFA	C0033687	Proteinuria	1	CTD_human
Tgene	VEGFA	C0033860	Psoriasis	1	CTD_human
Tgene	VEGFA	C0035228	Respiratory Hypersensitivity	1	CTD_human
Tgene	VEGFA	C0035309	Retinal Diseases	1	CTD_human
Tgene	VEGFA	C0035328	Retinal Vein Occlusion	1	CTD_human
Tgene	VEGFA	C0035412	Rhabdomyosarcoma	1	CTD_human
Tgene	VEGFA	C0036391	Schwartz-Jampel Syndrome	1	CTD_human
Tgene	VEGFA	C0038015	Spondyloepiphyseal Dysplasia	1	CTD_human
Tgene	VEGFA	C0038220	Status Epilepticus	1	CTD_human
Tgene	VEGFA	C0038358	Gastric ulcer	1	CTD_human
Tgene	VEGFA	C0038433	Streptozotocin Diabetes	1	CTD_human
Tgene	VEGFA	C0042076	Urologic Neoplasms	1	CTD_human
Tgene	VEGFA	C0085109	Corneal Neovascularization	1	CTD_human
Tgene	VEGFA	C0085605	Liver Failure	1	CTD_human
Tgene	VEGFA	C0086692	Benign Neoplasm	1	CTD_human
Tgene	VEGFA	C0153633	Malignant neoplasm of brain	1	CTD_human
Tgene	VEGFA	C0162351	Contact hypersensitivity	1	CTD_human
Tgene	VEGFA	C0178540	Cerebral Hypoxia-Ischemia	1	CTD_human
Tgene	VEGFA	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Tgene	VEGFA	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Tgene	VEGFA	C0205643	Carcinoma, Cribriform	1	CTD_human
Tgene	VEGFA	C0205644	Carcinoma, Granular Cell	1	CTD_human
Tgene	VEGFA	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Tgene	VEGFA	C0206726	gliosarcoma	1	CTD_human
Tgene	VEGFA	C0233794	Memory impairment	1	CTD_human
Tgene	VEGFA	C0239946	Fibrosis, Liver	1	CTD_human
Tgene	VEGFA	C0242350	Erectile dysfunction	1	CTD_human
Tgene	VEGFA	C0242383	Age related macular degeneration	1	CTD_human
Tgene	VEGFA	C0270823	Petit mal status	1	CTD_human
Tgene	VEGFA	C0271051	Macular retinal edema	1	CTD_human
Tgene	VEGFA	C0271178	Irvine-Gass Syndrome	1	CTD_human
Tgene	VEGFA	C0276496	Familial Alzheimer Disease (FAD)	1	CTD_human
Tgene	VEGFA	C0278996	Malignant Head and Neck Neoplasm	1	CTD_human
Tgene	VEGFA	C0282313	Condition, Preneoplastic	1	CTD_human
Tgene	VEGFA	C0311335	Grand Mal Status Epilepticus	1	CTD_human
Tgene	VEGFA	C0334588	Giant Cell Glioblastoma	1	CTD_human
Tgene	VEGFA	C0342257	Complications of Diabetes Mellitus	1	CTD_human
Tgene	VEGFA	C0393672	Epilepsy, Benign Psychomotor, Childhood	1	CTD_human
Tgene	VEGFA	C0393682	Epilepsy, Lateral Temporal	1	CTD_human
Tgene	VEGFA	C0393734	Complex Partial Status Epilepticus	1	CTD_human
Tgene	VEGFA	C0432272	Van Buchem disease	1	CTD_human
Tgene	VEGFA	C0476089	Endometrial Carcinoma	1	CTD_human
Tgene	VEGFA	C0494463	Alzheimer Disease, Late Onset	1	CTD_human
Tgene	VEGFA	C0496899	Benign neoplasm of brain, unspecified	1	CTD_human
Tgene	VEGFA	C0546126	Acute Confusional Senile Dementia	1	CTD_human
Tgene	VEGFA	C0600518	Choroidal Neovascularization	1	CTD_human
Tgene	VEGFA	C0678807	prenatal alcohol exposure	1	PSYGENET
Tgene	VEGFA	C0746787	Cancer of Neck	1	CTD_human
Tgene	VEGFA	C0750900	Alzheimer's Disease, Focal Onset	1	CTD_human
Tgene	VEGFA	C0750901	Alzheimer Disease, Early Onset	1	CTD_human
Tgene	VEGFA	C0750974	Brain Tumor, Primary	1	CTD_human
Tgene	VEGFA	C0750977	Recurrent Brain Neoplasm	1	CTD_human
Tgene	VEGFA	C0750979	Primary malignant neoplasm of brain	1	CTD_human
Tgene	VEGFA	C0751177	Cancer of Head	1	CTD_human
Tgene	VEGFA	C0751262	Adult Learning Disorders	1	CTD_human
Tgene	VEGFA	C0751263	Learning Disturbance	1	CTD_human
Tgene	VEGFA	C0751265	Learning Disabilities	1	CTD_human
Tgene	VEGFA	C0751292	Age-Related Memory Disorders	1	CTD_human
Tgene	VEGFA	C0751293	Memory Disorder, Semantic	1	CTD_human
Tgene	VEGFA	C0751294	Memory Disorder, Spatial	1	CTD_human
Tgene	VEGFA	C0751295	Memory Loss	1	CTD_human
Tgene	VEGFA	C0751522	Status Epilepticus, Subclinical	1	CTD_human
Tgene	VEGFA	C0751523	Non-Convulsive Status Epilepticus	1	CTD_human
Tgene	VEGFA	C0751524	Simple Partial Status Epilepticus	1	CTD_human
Tgene	VEGFA	C0751571	Cancer of Urinary Tract	1	CTD_human
Tgene	VEGFA	C0752304	Hypoxic-Ischemic Encephalopathy	1	CTD_human
Tgene	VEGFA	C0752305	Anoxic-Ischemic Encephalopathy	1	CTD_human
Tgene	VEGFA	C0752306	Anoxia-Ischemia, Brain	1	CTD_human
Tgene	VEGFA	C0752307	Anoxia-Ischemia, Cerebral	1	CTD_human
Tgene	VEGFA	C0752308	Hypoxia-Ischemia, Brain	1	CTD_human
Tgene	VEGFA	C0860207	Drug-Induced Liver Disease	1	CTD_human
Tgene	VEGFA	C0887833	Carcinoma, Pancreatic Ductal	1	CTD_human
Tgene	VEGFA	C0887900	Upper Aerodigestive Tract Neoplasms	1	CTD_human
Tgene	VEGFA	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Tgene	VEGFA	C1330966	Developmental Academic Disorder	1	CTD_human
Tgene	VEGFA	C1527390	Neoplasms, Intracranial	1	CTD_human
Tgene	VEGFA	C1527411	Thrombosis of retinal vein	1	CTD_human
Tgene	VEGFA	C1563937	Atherogenesis	1	CTD_human
Tgene	VEGFA	C1621958	Glioblastoma Multiforme	1	CTD_human
Tgene	VEGFA	C2063866	Depressive Disorder, Treatment-Resistant	1	PSYGENET
Tgene	VEGFA	C2717961	Thrombotic Microangiopathies	1	CTD_human
Tgene	VEGFA	C2931852	Clear-cell metastatic renal cell carcinoma	1	CTD_human
Tgene	VEGFA	C2937358	Cerebral Hemorrhage	1	CTD_human
Tgene	VEGFA	C3541456	Spondyloepiphyseal Dysplasia Tarda, X-Linked	1	CTD_human
Tgene	VEGFA	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Tgene	VEGFA	C4048328	cervical cancer	1	CTD_human
Tgene	VEGFA	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Tgene	VEGFA	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
Tgene	VEGFA	C4551479	Schwartz-Jampel Syndrome, Type 1	1	CTD_human