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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF532-NR3C1 (FusionGDB2 ID:101606)

Fusion Gene Summary for ZNF532-NR3C1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF532-NR3C1
Fusion gene ID: 101606
HgeneTgene
Gene symbol

ZNF532

NR3C1

Gene ID

55205

2908

Gene namezinc finger protein 532nuclear receptor subfamily 3 group C member 1
Synonyms-GCCR|GCR|GCRST|GR|GRL
Cytomap

18q21.32

5q31.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 532glucocorticoid receptorglucocorticoid nuclear receptor variant 1nuclear receptor subfamily 3 group C member 1 variant hGR-B(54)nuclear receptor subfamily 3 group C member 1 variant hGR-B(77)nuclear receptor subfamily 3 group C member 1 variant hGR-B(9
Modification date2020031320200327
UniProtAcc.

P04150

Ensembl transtripts involved in fusion geneENST00000336078, ENST00000591083, 
ENST00000589288, ENST00000591230, 
ENST00000591808, ENST00000588956, 
ENST00000394464, ENST00000343796, 
ENST00000415690, ENST00000424646, 
ENST00000504572, ENST00000394466, 
ENST00000231509, ENST00000416954, 
ENST00000503201, ENST00000504336, 
Fusion gene scores* DoF score12 X 11 X 10=13207 X 11 X 3=231
# samples 1612
** MAII scorelog2(16/1320*10)=-3.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/231*10)=-0.944858445807539
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF532 [Title/Abstract] AND NR3C1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF532(56532811)-NR3C1(142693733), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNR3C1

GO:0000122

negative regulation of transcription by RNA polymerase II

1894621

TgeneNR3C1

GO:0006351

transcription, DNA-templated

17081986

TgeneNR3C1

GO:0006355

regulation of transcription, DNA-templated

19141540

TgeneNR3C1

GO:0045892

negative regulation of transcription, DNA-templated

1894621

TgeneNR3C1

GO:0045944

positive regulation of transcription by RNA polymerase II

15769988|16728402|23823477

TgeneNR3C1

GO:0071383

cellular response to steroid hormone stimulus

15769988|17635946

TgeneNR3C1

GO:0071385

cellular response to glucocorticoid stimulus

9353307

TgeneNR3C1

GO:0071560

cellular response to transforming growth factor beta stimulus

12902338

TgeneNR3C1

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

27334923


check buttonFusion gene breakpoints across ZNF532 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NR3C1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HW-7489ZNF532chr18

56532811

+NR3C1chr5

142693733

-


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Fusion Gene ORF analysis for ZNF532-NR3C1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000336078ENST00000394464ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000336078ENST00000343796ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000336078ENST00000415690ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000336078ENST00000424646ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000336078ENST00000504572ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000336078ENST00000394466ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000336078ENST00000231509ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000336078ENST00000416954ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000336078ENST00000503201ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000336078ENST00000504336ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591083ENST00000394464ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591083ENST00000343796ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591083ENST00000415690ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591083ENST00000424646ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591083ENST00000504572ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591083ENST00000394466ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591083ENST00000231509ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000591083ENST00000416954ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000591083ENST00000503201ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000591083ENST00000504336ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000589288ENST00000394464ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000589288ENST00000343796ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000589288ENST00000415690ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000589288ENST00000424646ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000589288ENST00000504572ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000589288ENST00000394466ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000589288ENST00000231509ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000589288ENST00000416954ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000589288ENST00000503201ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000589288ENST00000504336ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591230ENST00000394464ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591230ENST00000343796ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591230ENST00000415690ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591230ENST00000424646ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591230ENST00000504572ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591230ENST00000394466ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591230ENST00000231509ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000591230ENST00000416954ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000591230ENST00000503201ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000591230ENST00000504336ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591808ENST00000394464ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591808ENST00000343796ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591808ENST00000415690ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591808ENST00000424646ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591808ENST00000504572ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591808ENST00000394466ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-3CDSENST00000591808ENST00000231509ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000591808ENST00000416954ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000591808ENST00000503201ZNF532chr18

56532811

+NR3C1chr5

142693733

-
5UTR-5UTRENST00000591808ENST00000504336ZNF532chr18

56532811

+NR3C1chr5

142693733

-
intron-3CDSENST00000588956ENST00000394464ZNF532chr18

56532811

+NR3C1chr5

142693733

-
intron-3CDSENST00000588956ENST00000343796ZNF532chr18

56532811

+NR3C1chr5

142693733

-
intron-3CDSENST00000588956ENST00000415690ZNF532chr18

56532811

+NR3C1chr5

142693733

-
intron-3CDSENST00000588956ENST00000424646ZNF532chr18

56532811

+NR3C1chr5

142693733

-
intron-3CDSENST00000588956ENST00000504572ZNF532chr18

56532811

+NR3C1chr5

142693733

-
intron-3CDSENST00000588956ENST00000394466ZNF532chr18

56532811

+NR3C1chr5

142693733

-
intron-3CDSENST00000588956ENST00000231509ZNF532chr18

56532811

+NR3C1chr5

142693733

-
intron-5UTRENST00000588956ENST00000416954ZNF532chr18

56532811

+NR3C1chr5

142693733

-
intron-5UTRENST00000588956ENST00000503201ZNF532chr18

56532811

+NR3C1chr5

142693733

-
intron-5UTRENST00000588956ENST00000504336ZNF532chr18

56532811

+NR3C1chr5

142693733

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZNF532-NR3C1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF532-NR3C1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NR3C1

P04150

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:25775514, ECO:0000269|PubMed:27120390, ECO:0000269|PubMed:9590696}.; FUNCTION: [Isoform Alpha]: Has transcriptional activation and repression activity (PubMed:15866175, PubMed:19248771, PubMed:20484466, PubMed:23820903, PubMed:11435610, PubMed:15769988, PubMed:17635946, PubMed:19141540, PubMed:21664385). Mediates glucocorticoid-induced apoptosis (PubMed:23303127). Promotes accurate chromosome segregation during mitosis (PubMed:25847991). May act as a tumor suppressor (PubMed:25847991). May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression (By similarity). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15769988, ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:17635946, ECO:0000269|PubMed:19141540, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:21664385, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903, ECO:0000269|PubMed:25847991}.; FUNCTION: [Isoform Beta]: Acts as a dominant negative inhibitor of isoform Alpha (PubMed:7769088, PubMed:8621628, PubMed:20484466). Has intrinsic transcriptional activity independent of isoform Alpha when both isoforms are coexpressed (PubMed:19248771, PubMed:26711253). Loses this transcription modulator function on its own (PubMed:20484466). Has no hormone-binding activity (PubMed:8621628). May play a role in controlling glucose metabolism by maintaining insulin sensitivity (By similarity). Reduces hepatic gluconeogenesis through down-regulation of PEPCK in an isoform Alpha-dependent manner (PubMed:26711253). Directly regulates STAT1 expression in isoform Alpha-independent manner (PubMed:26711253). {ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:19248771, ECO:0000269|PubMed:20484466, ECO:0000269|PubMed:26711253, ECO:0000269|PubMed:7769088, ECO:0000269|PubMed:8621628}.; FUNCTION: [Isoform Alpha-2]: Has lower transcriptional activation activity than isoform Alpha. Exerts a dominant negative effect on isoform Alpha trans-repression mechanism (PubMed:20484466).; FUNCTION: [Isoform GR-P]: Increases activity of isoform Alpha. {ECO:0000269|PubMed:11358809}.; FUNCTION: [Isoform Alpha-B]: More effective than isoform Alpha in transcriptional activation, but not repression activity. {ECO:0000269|PubMed:11435610, ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform 10]: Has transcriptional activation activity. {ECO:0000269|PubMed:20484466}.; FUNCTION: [Isoform Alpha-C1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-C3]: Has highest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). Mediates glucocorticoid-induced apoptosis (PubMed:23303127, PubMed:23820903). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.; FUNCTION: [Isoform Alpha-D1]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D2]: Has transcriptional activation activity. {ECO:0000269|PubMed:15866175}.; FUNCTION: [Isoform Alpha-D3]: Has lowest transcriptional activation activity of all isoforms created by alternative initiation (PubMed:15866175, PubMed:23820903). Has transcriptional repression activity (PubMed:23303127). {ECO:0000269|PubMed:15866175, ECO:0000269|PubMed:23303127, ECO:0000269|PubMed:23820903}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZNF532-NR3C1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZNF532-NR3C1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF532-NR3C1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNR3C1P04150DB00223DiflorasoneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00223DiflorasoneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00240AlclometasoneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00240AlclometasoneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00253MedrysoneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00253MedrysoneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00288AmcinonideAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00288AmcinonideAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00421SpironolactoneAntagonistSmall moleculeApproved
TgeneNR3C1P04150DB00421SpironolactoneAntagonistSmall moleculeApproved
TgeneNR3C1P04150DB00547DesoximetasoneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00547DesoximetasoneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00588Fluticasone propionateAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00588Fluticasone propionateAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00596UlobetasolAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00596UlobetasolAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00717NorethisteroneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00717NorethisteroneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00769HydrocortamateAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00769HydrocortamateAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00838ClocortoloneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00838ClocortoloneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00846FlurandrenolideAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00846FlurandrenolideAgonistSmall moleculeApproved
TgeneNR3C1P04150DB14596Loteprednol etabonateAgonistSmall moleculeApproved
TgeneNR3C1P04150DB14596Loteprednol etabonateAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00896RimexoloneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB00896RimexoloneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB01013Clobetasol propionateAgonistSmall moleculeApproved
TgeneNR3C1P04150DB01013Clobetasol propionateAgonistSmall moleculeApproved
TgeneNR3C1P04150DB01222BudesonideAntagonistSmall moleculeApproved
TgeneNR3C1P04150DB01222BudesonideAntagonistSmall moleculeApproved
TgeneNR3C1P04150DB01395DrospirenoneBinderSmall moleculeApproved
TgeneNR3C1P04150DB01395DrospirenoneBinderSmall moleculeApproved
TgeneNR3C1P04150DB06781DifluprednateAgonistSmall moleculeApproved
TgeneNR3C1P04150DB06781DifluprednateAgonistSmall moleculeApproved
TgeneNR3C1P04150DB08867UlipristalAntagonistSmall moleculeApproved
TgeneNR3C1P04150DB08867UlipristalAntagonistSmall moleculeApproved
TgeneNR3C1P04150DB08906Fluticasone furoateAgonistSmall moleculeApproved
TgeneNR3C1P04150DB08906Fluticasone furoateAgonistSmall moleculeApproved
TgeneNR3C1P04150DB11619GestrinoneAntagonistSmall moleculeApproved
TgeneNR3C1P04150DB11619GestrinoneAntagonistSmall moleculeApproved
TgeneNR3C1P04150DB13158ClobetasoneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB13158ClobetasoneAgonistSmall moleculeApproved
TgeneNR3C1P04150DB13867FluticasoneAgonistSmall moleculeApproved|Experimental
TgeneNR3C1P04150DB13867FluticasoneAgonistSmall moleculeApproved|Experimental
TgeneNR3C1P04150DB14583Segesterone acetateAgonistSmall moleculeApproved|Experimental|Investigational
TgeneNR3C1P04150DB14583Segesterone acetateAgonistSmall moleculeApproved|Experimental|Investigational
TgeneNR3C1P04150DB01185FluoxymesteroneAntagonistSmall moleculeApproved|Illicit
TgeneNR3C1P04150DB01185FluoxymesteroneAntagonistSmall moleculeApproved|Illicit
TgeneNR3C1P04150DB00180FlunisolideAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB00180FlunisolideAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB00324FluorometholoneAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB00324FluorometholoneAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB00367LevonorgestrelBinderSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB00367LevonorgestrelBinderSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB00394Beclomethasone dipropionateAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB00394Beclomethasone dipropionateAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB00687FludrocortisoneAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB00687FludrocortisoneAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB00834MifepristoneAntagonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB00834MifepristoneAntagonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB01047FluocinonideAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB01047FluocinonideAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB01130PrednicarbateAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB01130PrednicarbateAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB01260DesonideAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB01260DesonideAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB01380Cortisone acetateAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB01380Cortisone acetateAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB01410CiclesonideAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB01410CiclesonideAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB11921DeflazacortAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB11921DeflazacortAgonistSmall moleculeApproved|Investigational
TgeneNR3C1P04150DB00351Megestrol acetateAgonistSmall moleculeApproved|Investigational|Vet_approved
TgeneNR3C1P04150DB00351Megestrol acetateAgonistSmall moleculeApproved|Investigational|Vet_approved
TgeneNR3C1P04150DB00591Fluocinolone acetonideAgonistSmall moleculeApproved|Investigational|Vet_approved
TgeneNR3C1P04150DB00591Fluocinolone acetonideAgonistSmall moleculeApproved|Investigational|Vet_approved
TgeneNR3C1P04150DB01234DexamethasoneAgonistSmall moleculeApproved|Investigational|Vet_approved
TgeneNR3C1P04150DB01234DexamethasoneAgonistSmall moleculeApproved|Investigational|Vet_approved
TgeneNR3C1P04150DB14512Mometasone furoateSmall moleculeApproved|Investigational|Vet_approved
TgeneNR3C1P04150DB14512Mometasone furoateSmall moleculeApproved|Investigational|Vet_approved
TgeneNR3C1P04150DB14541Hydrocortisone cypionateSmall moleculeApproved|Investigational|Vet_approved
TgeneNR3C1P04150DB14541Hydrocortisone cypionateSmall moleculeApproved|Investigational|Vet_approved
TgeneNR3C1P04150DB14649Dexamethasone acetateAgonistSmall moleculeApproved|Investigational|Vet_approved
TgeneNR3C1P04150DB14649Dexamethasone acetateAgonistSmall moleculeApproved|Investigational|Vet_approved
TgeneNR3C1P04150DB09095DifluocortoloneBinderSmall moleculeApproved|Investigational|Withdrawn
TgeneNR3C1P04150DB09095DifluocortoloneBinderSmall moleculeApproved|Investigational|Withdrawn
TgeneNR3C1P04150DB00396ProgesteronePartial agonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00396ProgesteronePartial agonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00443BetamethasoneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00443BetamethasoneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00620TriamcinoloneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00620TriamcinoloneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00635PrednisoneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00635PrednisoneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00663FlumethasoneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00663FlumethasoneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00741HydrocortisoneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00741HydrocortisoneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00860PrednisoloneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00860PrednisoloneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00959MethylprednisoloneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB00959MethylprednisoloneAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14539Hydrocortisone acetateSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14539Hydrocortisone acetateSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14540Hydrocortisone butyrateSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14540Hydrocortisone butyrateSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14542Hydrocortisone phosphateSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14542Hydrocortisone phosphateSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14543Hydrocortisone probutateSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14543Hydrocortisone probutateSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14544Hydrocortisone valerateSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14544Hydrocortisone valerateSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14631Prednisolone phosphateAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14631Prednisolone phosphateAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14669Betamethasone phosphateAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB14669Betamethasone phosphateAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB15566Prednisolone acetateAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB15566Prednisolone acetateAgonistSmall moleculeApproved|Vet_approved
TgeneNR3C1P04150DB09091TixocortolBinderSmall moleculeApproved|Withdrawn
TgeneNR3C1P04150DB09091TixocortolBinderSmall moleculeApproved|Withdrawn
TgeneNR3C1P04150DB14538Hydrocortisone aceponateSmall moleculeExperimental|Vet_approved
TgeneNR3C1P04150DB14538Hydrocortisone aceponateSmall moleculeExperimental|Vet_approved

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Related Diseases for ZNF532-NR3C1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNR3C1C1841972Glucocorticoid Receptor Deficiency16CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneNR3C1C0005586Bipolar Disorder6CTD_human;PSYGENET
TgeneNR3C1C0011581Depressive disorder6CTD_human;PSYGENET
TgeneNR3C1C0041696Unipolar Depression6CTD_human;PSYGENET
TgeneNR3C1C0525045Mood Disorders6CTD_human;PSYGENET
TgeneNR3C1C0011570Mental Depression5PSYGENET
TgeneNR3C1C1269683Major Depressive Disorder5PSYGENET
TgeneNR3C1C0001969Alcoholic Intoxication2PSYGENET
TgeneNR3C1C0009171Cocaine Abuse2CTD_human
TgeneNR3C1C0020538Hypertensive disease2CTD_human
TgeneNR3C1C0036341Schizophrenia2CTD_human
TgeneNR3C1C0236736Cocaine-Related Disorders2CTD_human
TgeneNR3C1C0600427Cocaine Dependence2CTD_human
TgeneNR3C1C0004238Atrial Fibrillation1CTD_human
TgeneNR3C1C0005587Depression, Bipolar1CTD_human
TgeneNR3C1C0011573Endogenous depression1CTD_human
TgeneNR3C1C0013221Drug toxicity1CTD_human
TgeneNR3C1C0014175Endometriosis1CTD_human
TgeneNR3C1C0017614Glaucoma, Suspect1CTD_human
TgeneNR3C1C0020621Hypokalemia1CTD_human
TgeneNR3C1C0024713Manic Disorder1CTD_human
TgeneNR3C1C0025193Melancholia1CTD_human
TgeneNR3C1C0028840Ocular Hypertension1CTD_human
TgeneNR3C1C0033578Prostatic Neoplasms1CTD_human
TgeneNR3C1C0033958Psychosis, Brief Reactive1CTD_human
TgeneNR3C1C0033975Psychotic Disorders1CTD_human
TgeneNR3C1C0036337Schizoaffective Disorder1CTD_human
TgeneNR3C1C0036358Schizophreniform Disorders1CTD_human
TgeneNR3C1C0041755Adverse reaction to drug1CTD_human
TgeneNR3C1C0086133Depressive Syndrome1CTD_human
TgeneNR3C1C0235480Paroxysmal atrial fibrillation1CTD_human
TgeneNR3C1C0238394Female Pseudohermaphroditism1CTD_human
TgeneNR3C1C0269102Endometrioma1CTD_human
TgeneNR3C1C0282126Depression, Neurotic1CTD_human
TgeneNR3C1C0338831Manic1CTD_human
TgeneNR3C1C0376358Malignant neoplasm of prostate1CTD_human
TgeneNR3C1C0600260Lung Diseases, Obstructive1CTD_human
TgeneNR3C1C1257958Glucose Metabolism Disorders1CTD_human
TgeneNR3C1C2585653Persistent atrial fibrillation1CTD_human
TgeneNR3C1C293640346, XX Disorders of Sex Development1CTD_human
TgeneNR3C1C3468561familial atrial fibrillation1CTD_human