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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:ZNF709-MAN2B1 (FusionGDB2 ID:102090)

Fusion Gene Summary for ZNF709-MAN2B1

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF709-MAN2B1
Fusion gene ID: 102090
HgeneTgene
Gene symbol

ZNF709

MAN2B1

Gene ID

163051

4125

Gene namezinc finger protein 709mannosidase alpha class 2B member 1
Synonyms-LAMAN|MANB
Cytomap

19p13.2

19p13.13

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 709lysosomal alpha-mannosidaselysosomal acid alpha-mannosidasemannosidase alpha-Bmannosidase, alpha B, lysosomal
Modification date2020031320200313
UniProtAcc.

O00754

Ensembl transtripts involved in fusion geneENST00000397732, ENST00000428311, 
ENST00000493776, 		ENST00000456935, 
ENST00000221363, ENST00000495617, 
Fusion gene scores* DoF score4 X 4 X 4=648 X 10 X 5=400
# samples 69
** MAII scorelog2(6/64*10)=-0.0931094043914815
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/400*10)=-2.15200309344505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF709 [Title/Abstract] AND MAN2B1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF709(12595469)-MAN2B1(12758412), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAN2B1

GO:0006464

cellular protein modification process

8910458


check buttonFusion gene breakpoints across ZNF709 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MAN2B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-IR-A3LIZNF709chr19

12595468

-MAN2B1chr19

12758412

-
ChimerDB4CESCTCGA-IR-A3LI-01AZNF709chr19

12595469

-MAN2B1chr19

12758412

-
ChimerDB4CESCTCGA-IR-A3LI-01AZNF709chr19

12595469

-MAN2B1chr19

12758149

-
ChimerDB4CESCTCGA-IR-A3LI-01AZNF709chr19

12595469

-MAN2B1chr19

12758412

-
ChimerDB4CESCTCGA-IR-A3LI-01AZNF709chr19

12595468

-MAN2B1chr19

12758411

-


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Fusion Gene ORF analysis for ZNF709-MAN2B1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000397732ENST00000456935ZNF709chr19

12595468

-MAN2B1chr19

12758412

-
In-frameENST00000397732ENST00000221363ZNF709chr19

12595468

-MAN2B1chr19

12758412

-
5CDS-intronENST00000397732ENST00000495617ZNF709chr19

12595468

-MAN2B1chr19

12758412

-
intron-3CDSENST00000428311ENST00000456935ZNF709chr19

12595468

-MAN2B1chr19

12758412

-
intron-3CDSENST00000428311ENST00000221363ZNF709chr19

12595468

-MAN2B1chr19

12758412

-
intron-intronENST00000428311ENST00000495617ZNF709chr19

12595468

-MAN2B1chr19

12758412

-
intron-3CDSENST00000493776ENST00000456935ZNF709chr19

12595468

-MAN2B1chr19

12758412

-
intron-3CDSENST00000493776ENST00000221363ZNF709chr19

12595468

-MAN2B1chr19

12758412

-
intron-intronENST00000493776ENST00000495617ZNF709chr19

12595468

-MAN2B1chr19

12758412

-
In-frameENST00000397732ENST00000456935ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
In-frameENST00000397732ENST00000221363ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
5CDS-intronENST00000397732ENST00000495617ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
intron-3CDSENST00000428311ENST00000456935ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
intron-3CDSENST00000428311ENST00000221363ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
intron-intronENST00000428311ENST00000495617ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
intron-3CDSENST00000493776ENST00000456935ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
intron-3CDSENST00000493776ENST00000221363ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
intron-intronENST00000493776ENST00000495617ZNF709chr19

12595469

-MAN2B1chr19

12758412

-
In-frameENST00000397732ENST00000456935ZNF709chr19

12595469

-MAN2B1chr19

12758149

-
In-frameENST00000397732ENST00000221363ZNF709chr19

12595469

-MAN2B1chr19

12758149

-
5CDS-intronENST00000397732ENST00000495617ZNF709chr19

12595469

-MAN2B1chr19

12758149

-
intron-3CDSENST00000428311ENST00000456935ZNF709chr19

12595469

-MAN2B1chr19

12758149

-
intron-3CDSENST00000428311ENST00000221363ZNF709chr19

12595469

-MAN2B1chr19

12758149

-
intron-intronENST00000428311ENST00000495617ZNF709chr19

12595469

-MAN2B1chr19

12758149

-
intron-3CDSENST00000493776ENST00000456935ZNF709chr19

12595469

-MAN2B1chr19

12758149

-
intron-3CDSENST00000493776ENST00000221363ZNF709chr19

12595469

-MAN2B1chr19

12758149

-
intron-intronENST00000493776ENST00000495617ZNF709chr19

12595469

-MAN2B1chr19

12758149

-
In-frameENST00000397732ENST00000456935ZNF709chr19

12595468

-MAN2B1chr19

12758411

-
In-frameENST00000397732ENST00000221363ZNF709chr19

12595468

-MAN2B1chr19

12758411

-
5CDS-intronENST00000397732ENST00000495617ZNF709chr19

12595468

-MAN2B1chr19

12758411

-
intron-3CDSENST00000428311ENST00000456935ZNF709chr19

12595468

-MAN2B1chr19

12758411

-
intron-3CDSENST00000428311ENST00000221363ZNF709chr19

12595468

-MAN2B1chr19

12758411

-
intron-intronENST00000428311ENST00000495617ZNF709chr19

12595468

-MAN2B1chr19

12758411

-
intron-3CDSENST00000493776ENST00000456935ZNF709chr19

12595468

-MAN2B1chr19

12758411

-
intron-3CDSENST00000493776ENST00000221363ZNF709chr19

12595468

-MAN2B1chr19

12758411

-
intron-intronENST00000493776ENST00000495617ZNF709chr19

12595468

-MAN2B1chr19

12758411

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397732ZNF709chr1912595468-ENST00000456935MAN2B1chr1912758412-654175121546141
ENST00000397732ZNF709chr1912595468-ENST00000221363MAN2B1chr1912758412-651175121546141
ENST00000397732ZNF709chr1912595469-ENST00000456935MAN2B1chr1912758412-654175121546141
ENST00000397732ZNF709chr1912595469-ENST00000221363MAN2B1chr1912758412-651175121546141
ENST00000397732ZNF709chr1912595469-ENST00000456935MAN2B1chr1912758149-4981759497163
ENST00000397732ZNF709chr1912595469-ENST00000221363MAN2B1chr1912758149-4951759494162
ENST00000397732ZNF709chr1912595468-ENST00000456935MAN2B1chr1912758411-654175121546141
ENST00000397732ZNF709chr1912595468-ENST00000221363MAN2B1chr1912758411-651175121546141

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397732ENST00000456935ZNF709chr1912595468-MAN2B1chr1912758412-0.090178710.90982133
ENST00000397732ENST00000221363ZNF709chr1912595468-MAN2B1chr1912758412-0.09633330.90366673
ENST00000397732ENST00000456935ZNF709chr1912595469-MAN2B1chr1912758412-0.090178710.90982133
ENST00000397732ENST00000221363ZNF709chr1912595469-MAN2B1chr1912758412-0.09633330.90366673
ENST00000397732ENST00000456935ZNF709chr1912595469-MAN2B1chr1912758149-0.286982570.7130174
ENST00000397732ENST00000221363ZNF709chr1912595469-MAN2B1chr1912758149-0.296309740.70369023
ENST00000397732ENST00000456935ZNF709chr1912595468-MAN2B1chr1912758411-0.090178710.90982133
ENST00000397732ENST00000221363ZNF709chr1912595468-MAN2B1chr1912758411-0.09633330.90366673

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Fusion Genomic Features for ZNF709-MAN2B1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF709-MAN2B1


check button Go to

FGviewer for the breakpoints of chr19:12595468-chr19:12758412

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAN2B1

O00754

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-144_751.0642.0DomainKRAB
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-144_751.0642.0DomainKRAB
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-144_751.0642.0DomainKRAB
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-144_751.0642.0DomainKRAB
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14102_1241.0642.0Zinc fingerC2H2-type 1
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14140_1621.0642.0Zinc fingerC2H2-type 2
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14168_1901.0642.0Zinc fingerC2H2-type 3
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14196_2181.0642.0Zinc fingerC2H2-type 4
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14224_2461.0642.0Zinc fingerC2H2-type 5
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14252_2741.0642.0Zinc fingerC2H2-type 6
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14280_3021.0642.0Zinc fingerC2H2-type 7
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14308_3301.0642.0Zinc fingerC2H2-type 8
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14336_3581.0642.0Zinc fingerC2H2-type 9
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14364_3861.0642.0Zinc fingerC2H2-type 10
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14392_4141.0642.0Zinc fingerC2H2-type 11
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14420_4421.0642.0Zinc fingerC2H2-type 12
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14448_4701.0642.0Zinc fingerC2H2-type 13
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14476_4981.0642.0Zinc fingerC2H2-type 14
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14504_5261.0642.0Zinc fingerC2H2-type 15
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14532_5541.0642.0Zinc fingerC2H2-type 16
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14560_5821.0642.0Zinc fingerC2H2-type 17
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14588_6101.0642.0Zinc fingerC2H2-type 18
HgeneZNF709chr19:12595468chr19:12758411ENST00000397732-14616_6381.0642.0Zinc fingerC2H2-type 19
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14102_1241.0642.0Zinc fingerC2H2-type 1
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14140_1621.0642.0Zinc fingerC2H2-type 2
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14168_1901.0642.0Zinc fingerC2H2-type 3
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14196_2181.0642.0Zinc fingerC2H2-type 4
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14224_2461.0642.0Zinc fingerC2H2-type 5
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14252_2741.0642.0Zinc fingerC2H2-type 6
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14280_3021.0642.0Zinc fingerC2H2-type 7
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14308_3301.0642.0Zinc fingerC2H2-type 8
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14336_3581.0642.0Zinc fingerC2H2-type 9
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14364_3861.0642.0Zinc fingerC2H2-type 10
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14392_4141.0642.0Zinc fingerC2H2-type 11
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14420_4421.0642.0Zinc fingerC2H2-type 12
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14448_4701.0642.0Zinc fingerC2H2-type 13
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14476_4981.0642.0Zinc fingerC2H2-type 14
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14504_5261.0642.0Zinc fingerC2H2-type 15
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14532_5541.0642.0Zinc fingerC2H2-type 16
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14560_5821.0642.0Zinc fingerC2H2-type 17
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14588_6101.0642.0Zinc fingerC2H2-type 18
HgeneZNF709chr19:12595468chr19:12758412ENST00000397732-14616_6381.0642.0Zinc fingerC2H2-type 19
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14102_1241.0642.0Zinc fingerC2H2-type 1
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14140_1621.0642.0Zinc fingerC2H2-type 2
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14168_1901.0642.0Zinc fingerC2H2-type 3
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14196_2181.0642.0Zinc fingerC2H2-type 4
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14224_2461.0642.0Zinc fingerC2H2-type 5
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14252_2741.0642.0Zinc fingerC2H2-type 6
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14280_3021.0642.0Zinc fingerC2H2-type 7
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14308_3301.0642.0Zinc fingerC2H2-type 8
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14336_3581.0642.0Zinc fingerC2H2-type 9
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14364_3861.0642.0Zinc fingerC2H2-type 10
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14392_4141.0642.0Zinc fingerC2H2-type 11
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14420_4421.0642.0Zinc fingerC2H2-type 12
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14448_4701.0642.0Zinc fingerC2H2-type 13
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14476_4981.0642.0Zinc fingerC2H2-type 14
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14504_5261.0642.0Zinc fingerC2H2-type 15
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14532_5541.0642.0Zinc fingerC2H2-type 16
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14560_5821.0642.0Zinc fingerC2H2-type 17
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14588_6101.0642.0Zinc fingerC2H2-type 18
HgeneZNF709chr19:12595469chr19:12758149ENST00000397732-14616_6381.0642.0Zinc fingerC2H2-type 19
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14102_1241.0642.0Zinc fingerC2H2-type 1
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14140_1621.0642.0Zinc fingerC2H2-type 2
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14168_1901.0642.0Zinc fingerC2H2-type 3
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14196_2181.0642.0Zinc fingerC2H2-type 4
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14224_2461.0642.0Zinc fingerC2H2-type 5
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14252_2741.0642.0Zinc fingerC2H2-type 6
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14280_3021.0642.0Zinc fingerC2H2-type 7
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14308_3301.0642.0Zinc fingerC2H2-type 8
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14336_3581.0642.0Zinc fingerC2H2-type 9
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14364_3861.0642.0Zinc fingerC2H2-type 10
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14392_4141.0642.0Zinc fingerC2H2-type 11
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14420_4421.0642.0Zinc fingerC2H2-type 12
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14448_4701.0642.0Zinc fingerC2H2-type 13
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14476_4981.0642.0Zinc fingerC2H2-type 14
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14504_5261.0642.0Zinc fingerC2H2-type 15
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14532_5541.0642.0Zinc fingerC2H2-type 16
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14560_5821.0642.0Zinc fingerC2H2-type 17
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14588_6101.0642.0Zinc fingerC2H2-type 18
HgeneZNF709chr19:12595469chr19:12758412ENST00000397732-14616_6381.0642.0Zinc fingerC2H2-type 19


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Fusion Gene Sequence for ZNF709-MAN2B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000397732_ENST00000456935_TCGA-IR-A3LI_ZNF709_chr19_12595468_-_MAN2B1_chr19_12758412_length(transcript)=654nt_BP=175nt
GGAGGGGCGCTGCGCAAACGGCGAGGGCGTGGCTACCAGCCGCTGCGCTCCGCTCTGGGGTCTCCTCACCCCAGAAGGCCCTCAGGTGGA
GGAAGGGCCTCAGGTGGAGGTAGGACCTGTGCTGGCCGCGGGAGAGGTAAACAGAACACCAGGACATCCCAGAGTCTGGGAAATGTTCTC
AGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCA
GTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAACTTGAGGGACCTGTTCTCCACCTTCACCATCACCCG
CCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAACAAACACAGGCCCCACACCCCACCA
AACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGA
TGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCAGACCAGACTCTGACTCTCCTCTTGGGGCTGCTGCC

>In-frame_ENST00000397732_ENST00000456935_TCGA-IR-A3LI_ZNF709_chr19_12595468_-_MAN2B1_chr19_12758412_length(amino acids)=141AA_start in transcript=121_stop in transcript=546
MAAGEVNRTPGHPRVWEMFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQ

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>In-frame_ENST00000397732_ENST00000221363_TCGA-IR-A3LI_ZNF709_chr19_12595468_-_MAN2B1_chr19_12758412_length(transcript)=651nt_BP=175nt
GGAGGGGCGCTGCGCAAACGGCGAGGGCGTGGCTACCAGCCGCTGCGCTCCGCTCTGGGGTCTCCTCACCCCAGAAGGCCCTCAGGTGGA
GGAAGGGCCTCAGGTGGAGGTAGGACCTGTGCTGGCCGCGGGAGAGGTAAACAGAACACCAGGACATCCCAGAGTCTGGGAAATGTTCTC
AGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCA
GTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAACTTGAGGGACCTGTTCTCCACCTTCACCATCACCCG
CCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAACAAACACAGGCCCCACACCCCACCA
AACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGA
TGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCAGACCAGACTCTGACTCTCCTCTTGGGGCTGCTGCC

>In-frame_ENST00000397732_ENST00000221363_TCGA-IR-A3LI_ZNF709_chr19_12595468_-_MAN2B1_chr19_12758412_length(amino acids)=141AA_start in transcript=121_stop in transcript=546
MAAGEVNRTPGHPRVWEMFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQ

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>In-frame_ENST00000397732_ENST00000456935_TCGA-IR-A3LI-01A_ZNF709_chr19_12595469_-_MAN2B1_chr19_12758412_length(transcript)=654nt_BP=175nt
GGAGGGGCGCTGCGCAAACGGCGAGGGCGTGGCTACCAGCCGCTGCGCTCCGCTCTGGGGTCTCCTCACCCCAGAAGGCCCTCAGGTGGA
GGAAGGGCCTCAGGTGGAGGTAGGACCTGTGCTGGCCGCGGGAGAGGTAAACAGAACACCAGGACATCCCAGAGTCTGGGAAATGTTCTC
AGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCA
GTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAACTTGAGGGACCTGTTCTCCACCTTCACCATCACCCG
CCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAACAAACACAGGCCCCACACCCCACCA
AACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGA
TGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCAGACCAGACTCTGACTCTCCTCTTGGGGCTGCTGCC

>In-frame_ENST00000397732_ENST00000456935_TCGA-IR-A3LI-01A_ZNF709_chr19_12595469_-_MAN2B1_chr19_12758412_length(amino acids)=141AA_start in transcript=121_stop in transcript=546
MAAGEVNRTPGHPRVWEMFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQ

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>In-frame_ENST00000397732_ENST00000221363_TCGA-IR-A3LI-01A_ZNF709_chr19_12595469_-_MAN2B1_chr19_12758412_length(transcript)=651nt_BP=175nt
GGAGGGGCGCTGCGCAAACGGCGAGGGCGTGGCTACCAGCCGCTGCGCTCCGCTCTGGGGTCTCCTCACCCCAGAAGGCCCTCAGGTGGA
GGAAGGGCCTCAGGTGGAGGTAGGACCTGTGCTGGCCGCGGGAGAGGTAAACAGAACACCAGGACATCCCAGAGTCTGGGAAATGTTCTC
AGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCA
GTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAACTTGAGGGACCTGTTCTCCACCTTCACCATCACCCG
CCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAACAAACACAGGCCCCACACCCCACCA
AACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGA
TGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCAGACCAGACTCTGACTCTCCTCTTGGGGCTGCTGCC

>In-frame_ENST00000397732_ENST00000221363_TCGA-IR-A3LI-01A_ZNF709_chr19_12595469_-_MAN2B1_chr19_12758412_length(amino acids)=141AA_start in transcript=121_stop in transcript=546
MAAGEVNRTPGHPRVWEMFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQ

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>In-frame_ENST00000397732_ENST00000456935_TCGA-IR-A3LI-01A_ZNF709_chr19_12595469_-_MAN2B1_chr19_12758149_length(transcript)=498nt_BP=175nt
GGAGGGGCGCTGCGCAAACGGCGAGGGCGTGGCTACCAGCCGCTGCGCTCCGCTCTGGGGTCTCCTCACCCCAGAAGGCCCTCAGGTGGA
GGAAGGGCCTCAGGTGGAGGTAGGACCTGTGCTGGCCGCGGGAGAGGTAAACAGAACACCAGGACATCCCAGAGTCTGGGAAATGGACCT
GTTCTCCACCTTCACCATCACCCGCCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAAC
AAACACAGGCCCCACACCCCACCAAACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGC
CTCAGTTCAATGGAAGGAGGTGGATGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCAGACCAGACTCT

>In-frame_ENST00000397732_ENST00000456935_TCGA-IR-A3LI-01A_ZNF709_chr19_12595469_-_MAN2B1_chr19_12758149_length(amino acids)=163AA_start in transcript=9_stop in transcript=497
MRKRRGRGYQPLRSALGSPHPRRPSGGGRASGGGRTCAGRGRGKQNTRTSQSLGNGPVLHLHHHPPAGDHAGGQPAPRGSLQAQVDNKHR

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>In-frame_ENST00000397732_ENST00000221363_TCGA-IR-A3LI-01A_ZNF709_chr19_12595469_-_MAN2B1_chr19_12758149_length(transcript)=495nt_BP=175nt
GGAGGGGCGCTGCGCAAACGGCGAGGGCGTGGCTACCAGCCGCTGCGCTCCGCTCTGGGGTCTCCTCACCCCAGAAGGCCCTCAGGTGGA
GGAAGGGCCTCAGGTGGAGGTAGGACCTGTGCTGGCCGCGGGAGAGGTAAACAGAACACCAGGACATCCCAGAGTCTGGGAAATGGACCT
GTTCTCCACCTTCACCATCACCCGCCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAAC
AAACACAGGCCCCACACCCCACCAAACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGC
CTCAGTTCAATGGAAGGAGGTGGATGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCAGACCAGACTCT

>In-frame_ENST00000397732_ENST00000221363_TCGA-IR-A3LI-01A_ZNF709_chr19_12595469_-_MAN2B1_chr19_12758149_length(amino acids)=162AA_start in transcript=9_stop in transcript=494
MRKRRGRGYQPLRSALGSPHPRRPSGGGRASGGGRTCAGRGRGKQNTRTSQSLGNGPVLHLHHHPPAGDHAGGQPAPRGSLQAQVDNKHR

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>In-frame_ENST00000397732_ENST00000456935_TCGA-IR-A3LI-01A_ZNF709_chr19_12595468_-_MAN2B1_chr19_12758411_length(transcript)=654nt_BP=175nt
GGAGGGGCGCTGCGCAAACGGCGAGGGCGTGGCTACCAGCCGCTGCGCTCCGCTCTGGGGTCTCCTCACCCCAGAAGGCCCTCAGGTGGA
GGAAGGGCCTCAGGTGGAGGTAGGACCTGTGCTGGCCGCGGGAGAGGTAAACAGAACACCAGGACATCCCAGAGTCTGGGAAATGTTCTC
AGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCA
GTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAACTTGAGGGACCTGTTCTCCACCTTCACCATCACCCG
CCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAACAAACACAGGCCCCACACCCCACCA
AACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGA
TGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCAGACCAGACTCTGACTCTCCTCTTGGGGCTGCTGCC

>In-frame_ENST00000397732_ENST00000456935_TCGA-IR-A3LI-01A_ZNF709_chr19_12595468_-_MAN2B1_chr19_12758411_length(amino acids)=141AA_start in transcript=121_stop in transcript=546
MAAGEVNRTPGHPRVWEMFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQ

--------------------------------------------------------------
>In-frame_ENST00000397732_ENST00000221363_TCGA-IR-A3LI-01A_ZNF709_chr19_12595468_-_MAN2B1_chr19_12758411_length(transcript)=651nt_BP=175nt
GGAGGGGCGCTGCGCAAACGGCGAGGGCGTGGCTACCAGCCGCTGCGCTCCGCTCTGGGGTCTCCTCACCCCAGAAGGCCCTCAGGTGGA
GGAAGGGCCTCAGGTGGAGGTAGGACCTGTGCTGGCCGCGGGAGAGGTAAACAGAACACCAGGACATCCCAGAGTCTGGGAAATGTTCTC
AGGGCTGCGCAGGGACCTGCCGCCCTCGGTGCACCTGCTCACGCTGGCCAGCTGGGGCCCCGAAATGGTGCTGCTGCGCTTGGAGCACCA
GTTTGCCGTAGGAGAGGATTCCGGACGTAACCTGAGCGCCCCCGTTACCTTGAACTTGAGGGACCTGTTCTCCACCTTCACCATCACCCG
CCTGCAGGAGACCACGCTGGTGGCCAACCAGCTCCGCGAGGCAGCCTCCAGGCTCAAGTGGACAACAAACACAGGCCCCACACCCCACCA
AACTCCGTACCAGCTGGACCCGGCCAACATCACGCTGGAACCCATGGAAATCCGCACTTTCCTGGCCTCAGTTCAATGGAAGGAGGTGGA
TGGTTAGGTCTGCTGGGATGGGCCCTCCAAGCCCAAGCCTCCTGCTCCGGGGGCAGACCAGACTCTGACTCTCCTCTTGGGGCTGCTGCC

>In-frame_ENST00000397732_ENST00000221363_TCGA-IR-A3LI-01A_ZNF709_chr19_12595468_-_MAN2B1_chr19_12758411_length(amino acids)=141AA_start in transcript=121_stop in transcript=546
MAAGEVNRTPGHPRVWEMFSGLRRDLPPSVHLLTLASWGPEMVLLRLEHQFAVGEDSGRNLSAPVTLNLRDLFSTFTITRLQETTLVANQ

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Fusion Gene PPI Analysis for ZNF709-MAN2B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF709-MAN2B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF709-MAN2B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMAN2B1C0024748alpha-Mannosidosis7CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneMAN2B1C0017661IGA Glomerulonephritis1CTD_human