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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF736-CHMP1A (FusionGDB2 ID:102158)

Fusion Gene Summary for ZNF736-CHMP1A

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF736-CHMP1A
Fusion gene ID: 102158
HgeneTgene
Gene symbol

ZNF736

CHMP1A

Gene ID

728927

5119

Gene namezinc finger protein 736charged multivesicular body protein 1A
Synonyms-CHMP1|PCH8|PCOLN3|PRSM1|VPS46-1|VPS46A
Cytomap

7q11.21

16q24.3

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 736KRAB-containing zinc-finger repressor proteincharged multivesicular body protein 1acharged multivesicular body protein 1/chromatin modifying protein 1chromatin modifying protein 1Aprocollagen (type III) N-endopeptidaseprotease, metallo, 1, 33kDvacuolar protein sorting-associated protein 46-1
Modification date2020032020200313
UniProtAcc.

Q9HD42

Ensembl transtripts involved in fusion geneENST00000465343, ENST00000355095, 
ENST00000423484, 		ENST00000397901, 
ENST00000253475, ENST00000535997, 
ENST00000550102, ENST00000547614, 
Fusion gene scores* DoF score6 X 4 X 4=9645 X 11 X 21=10395
# samples 748
** MAII scorelog2(7/96*10)=-0.45567948377619
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10395*10)=-4.43671154213721
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF736 [Title/Abstract] AND CHMP1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF736(63797360)-CHMP1A(89713739), # samples:3
Anticipated loss of major functional domain due to fusion event.ZNF736-CHMP1A seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCHMP1A

GO:0007076

mitotic chromosome condensation

11559747

TgeneCHMP1A

GO:0016192

vesicle-mediated transport

11559748

TgeneCHMP1A

GO:0016458

gene silencing

11559747

TgeneCHMP1A

GO:0045892

negative regulation of transcription, DNA-templated

11559747


check buttonFusion gene breakpoints across ZNF736 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CHMP1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1F8-01AZNF736chr7

63797360

+CHMP1Achr16

89713739

-
ChimerDB4GBMTCGA-26-5133-01AZNF736chr7

63797360

+CHMP1Achr16

89713739

-
ChimerDB4GBMTCGA-06-0156-01AZNF736chr7

63797360

+CHMP1Achr16

89713739

-
ChiTaRS5.0N/ADB033525ZNF736chr7

63797362

+CHMP1Achr16

89713742

-


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Fusion Gene ORF analysis for ZNF736-CHMP1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000465343ENST00000397901ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
intron-3CDSENST00000465343ENST00000253475ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
intron-3CDSENST00000465343ENST00000535997ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
intron-3CDSENST00000465343ENST00000550102ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
intron-5UTRENST00000465343ENST00000547614ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
Frame-shiftENST00000355095ENST00000397901ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
In-frameENST00000355095ENST00000253475ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
Frame-shiftENST00000355095ENST00000535997ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
Frame-shiftENST00000355095ENST00000550102ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
5CDS-5UTRENST00000355095ENST00000547614ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
Frame-shiftENST00000423484ENST00000397901ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
In-frameENST00000423484ENST00000253475ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
Frame-shiftENST00000423484ENST00000535997ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
Frame-shiftENST00000423484ENST00000550102ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
5CDS-5UTRENST00000423484ENST00000547614ZNF736chr7

63797360

+CHMP1Achr16

89713739

-
intron-3CDSENST00000465343ENST00000397901ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
intron-3CDSENST00000465343ENST00000253475ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
intron-3CDSENST00000465343ENST00000535997ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
intron-3CDSENST00000465343ENST00000550102ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
intron-5UTRENST00000465343ENST00000547614ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
Frame-shiftENST00000355095ENST00000397901ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
In-frameENST00000355095ENST00000253475ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
Frame-shiftENST00000355095ENST00000535997ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
Frame-shiftENST00000355095ENST00000550102ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
5CDS-5UTRENST00000355095ENST00000547614ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
Frame-shiftENST00000423484ENST00000397901ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
In-frameENST00000423484ENST00000253475ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
Frame-shiftENST00000423484ENST00000535997ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
Frame-shiftENST00000423484ENST00000550102ZNF736chr7

63797362

+CHMP1Achr16

89713742

-
5CDS-5UTRENST00000423484ENST00000547614ZNF736chr7

63797362

+CHMP1Achr16

89713742

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355095ZNF736chr763797360+ENST00000253475CHMP1Achr1689713739-25155483221038238
ENST00000423484ZNF736chr763797360+ENST00000253475CHMP1Achr1689713739-2315348122838238
ENST00000355095ZNF736chr763797362+ENST00000253475CHMP1Achr1689713742-25155483221038238
ENST00000423484ZNF736chr763797362+ENST00000253475CHMP1Achr1689713742-2315348122838238

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355095ENST00000253475ZNF736chr763797360+CHMP1Achr1689713739-0.244851340.75514865
ENST00000423484ENST00000253475ZNF736chr763797360+CHMP1Achr1689713739-0.263033270.7369667
ENST00000355095ENST00000253475ZNF736chr763797362+CHMP1Achr1689713742-0.244851340.75514865
ENST00000423484ENST00000253475ZNF736chr763797362+CHMP1Achr1689713742-0.263033270.7369667

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Fusion Genomic Features for ZNF736-CHMP1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF736-CHMP1A


check button Go to

FGviewer for the breakpoints of chr7:63797360-chr16:89713739

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CHMP1A

Q9HD42

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing. {ECO:0000269|PubMed:11559747, ECO:0000269|PubMed:11559748, ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:23045692}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF736chr7:63797360chr16:89713739ENST00000355095+454_7575.33333333333333428.0DomainKRAB
HgeneZNF736chr7:63797360chr16:89713739ENST00000423484+344_7575.33333333333333428.0DomainKRAB
HgeneZNF736chr7:63797362chr16:89713742ENST00000355095+454_7575.33333333333333428.0DomainKRAB
HgeneZNF736chr7:63797362chr16:89713742ENST00000423484+344_7575.33333333333333428.0DomainKRAB
TgeneCHMP1Achr7:63797360chr16:89713739ENST0000039790137102_12484.0197.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP1Achr7:63797362chr16:89713742ENST0000039790137102_12484.0197.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP1Achr7:63797360chr16:89713739ENST0000039790137185_19584.0197.0MotifNote=MIT-interacting motif
TgeneCHMP1Achr7:63797362chr16:89713742ENST0000039790137185_19584.0197.0MotifNote=MIT-interacting motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZNF736chr7:63797360chr16:89713739ENST00000355095+45145_16775.33333333333333428.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF736chr7:63797360chr16:89713739ENST00000355095+45173_19575.33333333333333428.0Zinc fingerC2H2-type 2
HgeneZNF736chr7:63797360chr16:89713739ENST00000355095+45201_22375.33333333333333428.0Zinc fingerC2H2-type 3
HgeneZNF736chr7:63797360chr16:89713739ENST00000355095+45229_25175.33333333333333428.0Zinc fingerC2H2-type 4
HgeneZNF736chr7:63797360chr16:89713739ENST00000355095+45257_27975.33333333333333428.0Zinc fingerC2H2-type 5
HgeneZNF736chr7:63797360chr16:89713739ENST00000355095+45285_30775.33333333333333428.0Zinc fingerC2H2-type 6
HgeneZNF736chr7:63797360chr16:89713739ENST00000355095+45313_33575.33333333333333428.0Zinc fingerC2H2-type 7
HgeneZNF736chr7:63797360chr16:89713739ENST00000355095+45341_36375.33333333333333428.0Zinc fingerC2H2-type 8
HgeneZNF736chr7:63797360chr16:89713739ENST00000355095+45369_39175.33333333333333428.0Zinc fingerC2H2-type 9
HgeneZNF736chr7:63797360chr16:89713739ENST00000355095+45397_41975.33333333333333428.0Zinc fingerC2H2-type 10
HgeneZNF736chr7:63797360chr16:89713739ENST00000423484+34145_16775.33333333333333428.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF736chr7:63797360chr16:89713739ENST00000423484+34173_19575.33333333333333428.0Zinc fingerC2H2-type 2
HgeneZNF736chr7:63797360chr16:89713739ENST00000423484+34201_22375.33333333333333428.0Zinc fingerC2H2-type 3
HgeneZNF736chr7:63797360chr16:89713739ENST00000423484+34229_25175.33333333333333428.0Zinc fingerC2H2-type 4
HgeneZNF736chr7:63797360chr16:89713739ENST00000423484+34257_27975.33333333333333428.0Zinc fingerC2H2-type 5
HgeneZNF736chr7:63797360chr16:89713739ENST00000423484+34285_30775.33333333333333428.0Zinc fingerC2H2-type 6
HgeneZNF736chr7:63797360chr16:89713739ENST00000423484+34313_33575.33333333333333428.0Zinc fingerC2H2-type 7
HgeneZNF736chr7:63797360chr16:89713739ENST00000423484+34341_36375.33333333333333428.0Zinc fingerC2H2-type 8
HgeneZNF736chr7:63797360chr16:89713739ENST00000423484+34369_39175.33333333333333428.0Zinc fingerC2H2-type 9
HgeneZNF736chr7:63797360chr16:89713739ENST00000423484+34397_41975.33333333333333428.0Zinc fingerC2H2-type 10
HgeneZNF736chr7:63797362chr16:89713742ENST00000355095+45145_16775.33333333333333428.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF736chr7:63797362chr16:89713742ENST00000355095+45173_19575.33333333333333428.0Zinc fingerC2H2-type 2
HgeneZNF736chr7:63797362chr16:89713742ENST00000355095+45201_22375.33333333333333428.0Zinc fingerC2H2-type 3
HgeneZNF736chr7:63797362chr16:89713742ENST00000355095+45229_25175.33333333333333428.0Zinc fingerC2H2-type 4
HgeneZNF736chr7:63797362chr16:89713742ENST00000355095+45257_27975.33333333333333428.0Zinc fingerC2H2-type 5
HgeneZNF736chr7:63797362chr16:89713742ENST00000355095+45285_30775.33333333333333428.0Zinc fingerC2H2-type 6
HgeneZNF736chr7:63797362chr16:89713742ENST00000355095+45313_33575.33333333333333428.0Zinc fingerC2H2-type 7
HgeneZNF736chr7:63797362chr16:89713742ENST00000355095+45341_36375.33333333333333428.0Zinc fingerC2H2-type 8
HgeneZNF736chr7:63797362chr16:89713742ENST00000355095+45369_39175.33333333333333428.0Zinc fingerC2H2-type 9
HgeneZNF736chr7:63797362chr16:89713742ENST00000355095+45397_41975.33333333333333428.0Zinc fingerC2H2-type 10
HgeneZNF736chr7:63797362chr16:89713742ENST00000423484+34145_16775.33333333333333428.0Zinc fingerC2H2-type 1%3B degenerate
HgeneZNF736chr7:63797362chr16:89713742ENST00000423484+34173_19575.33333333333333428.0Zinc fingerC2H2-type 2
HgeneZNF736chr7:63797362chr16:89713742ENST00000423484+34201_22375.33333333333333428.0Zinc fingerC2H2-type 3
HgeneZNF736chr7:63797362chr16:89713742ENST00000423484+34229_25175.33333333333333428.0Zinc fingerC2H2-type 4
HgeneZNF736chr7:63797362chr16:89713742ENST00000423484+34257_27975.33333333333333428.0Zinc fingerC2H2-type 5
HgeneZNF736chr7:63797362chr16:89713742ENST00000423484+34285_30775.33333333333333428.0Zinc fingerC2H2-type 6
HgeneZNF736chr7:63797362chr16:89713742ENST00000423484+34313_33575.33333333333333428.0Zinc fingerC2H2-type 7
HgeneZNF736chr7:63797362chr16:89713742ENST00000423484+34341_36375.33333333333333428.0Zinc fingerC2H2-type 8
HgeneZNF736chr7:63797362chr16:89713742ENST00000423484+34369_39175.33333333333333428.0Zinc fingerC2H2-type 9
HgeneZNF736chr7:63797362chr16:89713742ENST00000423484+34397_41975.33333333333333428.0Zinc fingerC2H2-type 10
TgeneCHMP1Achr7:63797360chr16:89713739ENST00000397901375_4784.0197.0Coiled coilOntology_term=ECO:0000255
TgeneCHMP1Achr7:63797362chr16:89713742ENST00000397901375_4784.0197.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for ZNF736-CHMP1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000355095_ENST00000253475_TCGA-BH-A1F8-01A_ZNF736_chr7_63797360_+_CHMP1A_chr16_89713739_length(transcript)=2515nt_BP=548nt
GGTGGCCAACTTGGGTGTCTTCCTCTGCCAGGGTCAAGGACAAGGATTGAAACGGGTGGGGCCTGGAGCCCTAGCCAATCAGTGGCGCCA
GCGTGAAACTGTCCAATCAAGTGCGCAGCTACAGAGGAAGAGGCGGCCTCTTCAATATGGCGGGGCCTTTGTCTCCTAGCTTCCGGGCTC
TGATCCTAGTTCGCGTCTCCACTGTTCCATCTCCTCCGTTCCTGGAGTTCCTCGGTGACTCTACTATAGCTTCTGTTATCCTGTGACCTG
CAGGTACTGGGAGATCCATAGGGAGGACGGCGGAACATCTGGAGGCTGGGAAATGGGAGTGTTGACATTCAGGGATGTGGCTGTAGAATT
CTCCCCAGAAGAGTGGGAATGCCTGGACTCTGCTCAGCAGCGTTTGTATAGGGATGTGATGTTAGAGAACTATGGAAACCTGGTCTCCTT
GGGTCTTGCTATCTTTAAGCCAGACTTGATGACCTGTCTGGAGCAAAGAAAAGAGCCTTGGAAAGTGAAGAGACAGGAGGCAGTAGCCAA
ACACCCAGGTGACCAAGAATATGGCCCAGGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGA
TGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGC
CGCAGGAGCAGGTGGACAGCCTCATCATGCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCG
CCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCG
GTGTGCACCGCCTCTGCCCCGTGATGTGCTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCG
GCCGGCAGCCACTCTGCGTCTCTCACCTGCCAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTC
CTGGTGTTGAGTTTCTGCAAATTTCTGGGGGTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCA
CCCAGCACTGTGGGGGCCTTCAGACTCTGGGGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAAC
AACTCCCTGAGGCCTCTCCGCACCACCTCAGCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATG
TGTGCTGGGGGATGTCAGGTGCCACCCAACGCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCT
CGGCCGCCCCTACCAGCTGGCTGAGCCCCCTGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAG
AACCGTCACTCAGATCCACATTCAAGTGTGCCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACAT
GTGCTGTGCTGTTTGTCTCCTCGACAGGGAGCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCA
GCCTGGTTCTCCCGGAGGACCTTTCCTTGGGGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTG
CCTTCCCCGACCACACCCCAATGCCTTCCCAGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTG
GGGTTGGGGCTGCTGTGAGGAAAACCTGCCATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGA
GGCTTTGGGCACAGCCTGCTGTCTTTTCCATTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAA
GTAGAAAAGGCAGGTGGTGGGCGGCTGGCAGGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCC
CGTGCAGCCCATGCTGAGGCTGCAGTGGTGTCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTT
CTTTTCAGAACTTGGGAGCCCCCAGGGAGGGGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGT
GTTGAGAGAACGTCCTTCTGTCCATCGTGGGTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTC

>In-frame_ENST00000355095_ENST00000253475_TCGA-BH-A1F8-01A_ZNF736_chr7_63797360_+_CHMP1A_chr16_89713739_length(amino acids)=238AA_start in transcript=322_stop in transcript=1038
MGVLTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLVSLGLAIFKPDLMTCLEQRKEPWKVKRQEAVAKHPGDQEYGPGDQSPGQG
PEHHGPAEGLLSDGQVRAAGAEPGRPYIGDGGLHELGHHPDHAAGAGGQPHHADRRGEWPGGAGPAQPAARGRLCRGRELCAQPGGPAVT

--------------------------------------------------------------
>In-frame_ENST00000423484_ENST00000253475_TCGA-BH-A1F8-01A_ZNF736_chr7_63797360_+_CHMP1A_chr16_89713739_length(transcript)=2315nt_BP=348nt
ACTGTTCCATCTCCTCCGTTCCTGGAGTTCCTCGGTGACTCTACTATAGCTTCTGTTATCCTGTGACCTGCAGGTACTGGGAGATCCATA
GGGAGGACGGCGGAACATCTGGAGGCTGGGAAATGGGAGTGTTGACATTCAGGGATGTGGCTGTAGAATTCTCCCCAGAAGAGTGGGAAT
GCCTGGACTCTGCTCAGCAGCGTTTGTATAGGGATGTGATGTTAGAGAACTATGGAAACCTGGTCTCCTTGGGTCTTGCTATCTTTAAGC
CAGACTTGATGACCTGTCTGGAGCAAAGAAAAGAGCCTTGGAAAGTGAAGAGACAGGAGGCAGTAGCCAAACACCCAGGTGACCAAGAAT
ATGGCCCAGGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAG
GTGCAGAACCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGC
CTCATCATGCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGC
TCTGTGCGCAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCC
GTGATGTGCTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTC
TCTCACCTGCCAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGGTGTTGAGTTTCTGCAA
ATTTCTGGGGGTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCAGCACTGTGGGGGCCTT
CAGACTCTGGGGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACTCCCTGAGGCCTCTCCG
CACCACCTCAGCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTGCTGGGGGATGTCAGGT
GCCACCCAACGCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGCCGCCCCTACCAGCTGG
CTGAGCCCCCTGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACCGTCACTCAGATCCACA
TTCAAGTGTGCCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGCTGTGCTGTTTGTCTCC
TCGACAGGGAGCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCTGGTTCTCCCGGAGGAC
CTTTCCTTGGGGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTTCCCCGACCACACCCCA
ATGCCTTCCCAGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGTTGGGGCTGCTGTGAGG
AAAACCTGCCATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCTTTGGGCACAGCCTGCT
GTCTTTTCCATTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAGAAAAGGCAGGTGGTGG
GCGGCTGGCAGGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTGCAGCCCATGCTGAGGC
TGCAGTGGTGTCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTTTCAGAACTTGGGAGCC
CCCAGGGAGGGGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTGAGAGAACGTCCTTCTG
TCCATCGTGGGTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTCCTGTCCCCTTGGGCAC

>In-frame_ENST00000423484_ENST00000253475_TCGA-BH-A1F8-01A_ZNF736_chr7_63797360_+_CHMP1A_chr16_89713739_length(amino acids)=238AA_start in transcript=122_stop in transcript=838
MGVLTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLVSLGLAIFKPDLMTCLEQRKEPWKVKRQEAVAKHPGDQEYGPGDQSPGQG
PEHHGPAEGLLSDGQVRAAGAEPGRPYIGDGGLHELGHHPDHAAGAGGQPHHADRRGEWPGGAGPAQPAARGRLCRGRELCAQPGGPAVT

--------------------------------------------------------------
>In-frame_ENST00000355095_ENST00000253475_DB033525_ZNF736_chr7_63797362_+_CHMP1A_chr16_89713742_length(transcript)=2515nt_BP=548nt
GGTGGCCAACTTGGGTGTCTTCCTCTGCCAGGGTCAAGGACAAGGATTGAAACGGGTGGGGCCTGGAGCCCTAGCCAATCAGTGGCGCCA
GCGTGAAACTGTCCAATCAAGTGCGCAGCTACAGAGGAAGAGGCGGCCTCTTCAATATGGCGGGGCCTTTGTCTCCTAGCTTCCGGGCTC
TGATCCTAGTTCGCGTCTCCACTGTTCCATCTCCTCCGTTCCTGGAGTTCCTCGGTGACTCTACTATAGCTTCTGTTATCCTGTGACCTG
CAGGTACTGGGAGATCCATAGGGAGGACGGCGGAACATCTGGAGGCTGGGAAATGGGAGTGTTGACATTCAGGGATGTGGCTGTAGAATT
CTCCCCAGAAGAGTGGGAATGCCTGGACTCTGCTCAGCAGCGTTTGTATAGGGATGTGATGTTAGAGAACTATGGAAACCTGGTCTCCTT
GGGTCTTGCTATCTTTAAGCCAGACTTGATGACCTGTCTGGAGCAAAGAAAAGAGCCTTGGAAAGTGAAGAGACAGGAGGCAGTAGCCAA
ACACCCAGGTGACCAAGAATATGGCCCAGGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGA
TGGACAGGTTCGAGCAGCAGGTGCAGAACCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGC
CGCAGGAGCAGGTGGACAGCCTCATCATGCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCG
CCTCTGCCGTGGGCGAGAGCTCTGTGCGCAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCG
GTGTGCACCGCCTCTGCCCCGTGATGTGCTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCG
GCCGGCAGCCACTCTGCGTCTCTCACCTGCCAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTC
CTGGTGTTGAGTTTCTGCAAATTTCTGGGGGTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCA
CCCAGCACTGTGGGGGCCTTCAGACTCTGGGGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAAC
AACTCCCTGAGGCCTCTCCGCACCACCTCAGCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATG
TGTGCTGGGGGATGTCAGGTGCCACCCAACGCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCT
CGGCCGCCCCTACCAGCTGGCTGAGCCCCCTGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAG
AACCGTCACTCAGATCCACATTCAAGTGTGCCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACAT
GTGCTGTGCTGTTTGTCTCCTCGACAGGGAGCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCA
GCCTGGTTCTCCCGGAGGACCTTTCCTTGGGGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTG
CCTTCCCCGACCACACCCCAATGCCTTCCCAGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTG
GGGTTGGGGCTGCTGTGAGGAAAACCTGCCATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGA
GGCTTTGGGCACAGCCTGCTGTCTTTTCCATTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAA
GTAGAAAAGGCAGGTGGTGGGCGGCTGGCAGGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCC
CGTGCAGCCCATGCTGAGGCTGCAGTGGTGTCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTT
CTTTTCAGAACTTGGGAGCCCCCAGGGAGGGGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGT
GTTGAGAGAACGTCCTTCTGTCCATCGTGGGTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTC

>In-frame_ENST00000355095_ENST00000253475_DB033525_ZNF736_chr7_63797362_+_CHMP1A_chr16_89713742_length(amino acids)=238AA_start in transcript=322_stop in transcript=1038
MGVLTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLVSLGLAIFKPDLMTCLEQRKEPWKVKRQEAVAKHPGDQEYGPGDQSPGQG
PEHHGPAEGLLSDGQVRAAGAEPGRPYIGDGGLHELGHHPDHAAGAGGQPHHADRRGEWPGGAGPAQPAARGRLCRGRELCAQPGGPAVT

--------------------------------------------------------------
>In-frame_ENST00000423484_ENST00000253475_DB033525_ZNF736_chr7_63797362_+_CHMP1A_chr16_89713742_length(transcript)=2315nt_BP=348nt
ACTGTTCCATCTCCTCCGTTCCTGGAGTTCCTCGGTGACTCTACTATAGCTTCTGTTATCCTGTGACCTGCAGGTACTGGGAGATCCATA
GGGAGGACGGCGGAACATCTGGAGGCTGGGAAATGGGAGTGTTGACATTCAGGGATGTGGCTGTAGAATTCTCCCCAGAAGAGTGGGAAT
GCCTGGACTCTGCTCAGCAGCGTTTGTATAGGGATGTGATGTTAGAGAACTATGGAAACCTGGTCTCCTTGGGTCTTGCTATCTTTAAGC
CAGACTTGATGACCTGTCTGGAGCAAAGAAAAGAGCCTTGGAAAGTGAAGAGACAGGAGGCAGTAGCCAAACACCCAGGTGACCAAGAAT
ATGGCCCAGGTGACCAAAGCCCTGGACAAGGCCCTGAGCACCATGGACCTGCAGAAGGTCTCCTCAGTGATGGACAGGTTCGAGCAGCAG
GTGCAGAACCTGGACGTCCATACATCGGTGATGGAGGACTCCATGAGCTCGGCCACCACCCTGACCACGCCGCAGGAGCAGGTGGACAGC
CTCATCATGCAGATCGCCGAGGAGAATGGCCTGGAGGTGCTGGACCAGCTCAGCCAGCTGCCCGAGGGCGCCTCTGCCGTGGGCGAGAGC
TCTGTGCGCAGCCAGGAGGACCAGCTGTCACGGAGGTTGGCCGCCTTGAGGAACTAGCCGTGCCCCGCCGGTGTGCACCGCCTCTGCCCC
GTGATGTGCTGGAAGGCTCCTGTCCTCTCCCCACCGCGTCTTGCCTTTGTGCTGACCCCGCGGGGCTGCGGCCGGCAGCCACTCTGCGTC
TCTCACCTGCCAGGCCTGCGTGGCCTTAGGGTTGTTCCTGTTCTTTTAGGTTGGGCGGTGGGTCTGTGTCCTGGTGTTGAGTTTCTGCAA
ATTTCTGGGGGTGATTTCTGTGACTCTGGGCCCACAGCGGGGAGGCCAAGAGGGGCCCTGTGGACTTTCACCCAGCACTGTGGGGGCCTT
CAGACTCTGGGGCAGCAGACATGCTGCTTCCCATCAGCCAGAGGGGGTCAGGGCTGCCCTGTTGCCAAACAACTCCCTGAGGCCTCTCCG
CACCACCTCAGCGGGCAGGAGGTCCCACCATGTGGACAGACATAGCCCAAGGAGGCACCACAGGTCTATGTGTGCTGGGGGATGTCAGGT
GCCACCCAACGCTGTCCTGGTGGTATTTACAATGACATCCTCCTCCTCCATCACTCCAGGGGTGGTGTCTCGGCCGCCCCTACCAGCTGG
CTGAGCCCCCTGGCCTCCTGCGCTCCCTCACTTCCCTCAGTTCCCAAAGCTGCCCAGTCCATGGGGACAGAACCGTCACTCAGATCCACA
TTCAAGTGTGCCCACCCTGCAGTCTTCATCCTCACTCAGCTGCTGCCTCTGGAGGTGCCTTTGGCCACATGTGCTGTGCTGTTTGTCTCC
TCGACAGGGAGCCTGTCCACCAGCAGGCTGCGGTCCCAGCGGGTGCGTCTGCAGCTCCTCCCCTTGGGCAGCCTGGTTCTCCCGGAGGAC
CTTTCCTTGGGGCCCTGCTTCATGACGATGCTGCCTGTGTCACCCTCTACCATCTGTAAACAACTGGGTGCCTTCCCCGACCACACCCCA
ATGCCTTCCCAGCTTGGAAGCCAAGGCAGCTGATGAAGGGAGCTCAGGAGAGCCGTCTTCAGCTGGGCTGGGGTTGGGGCTGCTGTGAGG
AAAACCTGCCATTGTGGCCCTGGAGAGTCACCAGCAGCTCTTGGGAAGGACTTGCTGGGAGGCTGAGAGAGGCTTTGGGCACAGCCTGCT
GTCTTTTCCATTTCCTAAAGTTTACTTCATTGTCTTGAGGCTTCCAGGTTTTGTTTTTGTTTTTGCCAAAGTAGAAAAGGCAGGTGGTGG
GCGGCTGGCAGGGAGTGCGGGTCCCCGCCCCTCTTCAGTCCTGCCCTCCCCTCCTCAGTCCTGCCCACCCCGTGCAGCCCATGCTGAGGC
TGCAGTGGTGTCGTGGGTGTTACGTGCAGGAACGTGGAGACCCTGACGTGGGCTCACTGCGTTTGGTTTTCTTTTCAGAACTTGGGAGCC
CCCAGGGAGGGGCTAGTGTTGGTAGGTCCTAGACGTGGTTCCCTCCAGCCTCCCCAAAATCAACCCTGGTGTTGAGAGAACGTCCTTCTG
TCCATCGTGGGTAACAGCCTTGGGGAGGGTGCAGAGCTCTGCAGAGCCATGGGCCAGGTGGGGCTGCCTCAGTCCTGTCCCCTTGGGCAC

>In-frame_ENST00000423484_ENST00000253475_DB033525_ZNF736_chr7_63797362_+_CHMP1A_chr16_89713742_length(amino acids)=238AA_start in transcript=122_stop in transcript=838
MGVLTFRDVAVEFSPEEWECLDSAQQRLYRDVMLENYGNLVSLGLAIFKPDLMTCLEQRKEPWKVKRQEAVAKHPGDQEYGPGDQSPGQG
PEHHGPAEGLLSDGQVRAAGAEPGRPYIGDGGLHELGHHPDHAAGAGGQPHHADRRGEWPGGAGPAQPAARGRLCRGRELCAQPGGPAVT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZNF736-CHMP1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF736-CHMP1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF736-CHMP1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCHMP1AC0266468Congenital pontocerebellar hypoplasia1GENOMICS_ENGLAND
TgeneCHMP1AC3554209Congenital pontocerebellar hypoplasia type 81CTD_human;GENOMICS_ENGLAND;ORPHANET