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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZNF827-C2CD5 (FusionGDB2 ID:102331)

Fusion Gene Summary for ZNF827-C2CD5

check button Fusion gene summary
Fusion gene informationFusion gene name: ZNF827-C2CD5
Fusion gene ID: 102331
HgeneTgene
Gene symbol

ZNF827

C2CD5

Gene ID

152485

9847

Gene namezinc finger protein 827C2 calcium dependent domain containing 5
Synonyms-CDP138|KIAA0528
Cytomap

4q31.21-q31.22

12p12.1

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein 827C2 domain-containing protein 5138 kDa C2 domain-containing phosphoprotein
Modification date2020031320200313
UniProtAcc.

Q86YS7

Ensembl transtripts involved in fusion geneENST00000508784, ENST00000513320, 
ENST00000379448, ENST00000511534, 
ENST00000333957, ENST00000446597, 
ENST00000536386, ENST00000396028, 
ENST00000542676, ENST00000544930, 
ENST00000545552, ENST00000540703, 
Fusion gene scores* DoF score6 X 7 X 4=1688 X 8 X 4=256
# samples 68
** MAII scorelog2(6/168*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZNF827 [Title/Abstract] AND C2CD5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZNF827(146859886)-C2CD5(22676440), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneC2CD5

GO:0032869

cellular response to insulin stimulus

21907143


check buttonFusion gene breakpoints across ZNF827 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across C2CD5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA262608ZNF827chr4

146859886

+C2CD5chr12

22676440

+
ChiTaRS5.0N/AAA279214ZNF827chr4

146859886

+C2CD5chr12

22676440

+


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Fusion Gene ORF analysis for ZNF827-C2CD5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000508784ENST00000333957ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000508784ENST00000446597ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000508784ENST00000536386ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000508784ENST00000396028ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000508784ENST00000542676ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000508784ENST00000544930ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000508784ENST00000545552ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-5UTRENST00000508784ENST00000540703ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000513320ENST00000333957ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000513320ENST00000446597ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000513320ENST00000536386ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000513320ENST00000396028ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000513320ENST00000542676ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000513320ENST00000544930ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000513320ENST00000545552ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-5UTRENST00000513320ENST00000540703ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000379448ENST00000333957ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000379448ENST00000446597ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000379448ENST00000536386ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000379448ENST00000396028ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000379448ENST00000542676ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000379448ENST00000544930ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000379448ENST00000545552ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-5UTRENST00000379448ENST00000540703ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000511534ENST00000333957ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000511534ENST00000446597ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000511534ENST00000536386ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000511534ENST00000396028ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000511534ENST00000542676ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000511534ENST00000544930ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-3CDSENST00000511534ENST00000545552ZNF827chr4

146859886

+C2CD5chr12

22676440

+
intron-5UTRENST00000511534ENST00000540703ZNF827chr4

146859886

+C2CD5chr12

22676440

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ZNF827-C2CD5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNF827-C2CD5


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.C2CD5

Q86YS7

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269|PubMed:21907143}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ZNF827-C2CD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ZNF827-C2CD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZNF827-C2CD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZNF827-C2CD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource