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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ZNFX1-DDB1 (FusionGDB2 ID:102424)

Fusion Gene Summary for ZNFX1-DDB1

Fusion gene summary

Fusion gene information	Fusion gene name: ZNFX1-DDB1
	Fusion gene ID: 102424
		Hgene	Tgene
	Gene symbol	ZNFX1	DDB1
	Gene ID	57169	1642
	Gene name	zinc finger NFX1-type containing 1	damage specific DNA binding protein 1
	Synonyms	-	DDBA\|UV-DDB1\|XAP1\|XPCE\|XPE\|XPE-BF
	Cytomap	20q13.13	11q12.2
	Type of gene	protein-coding	protein-coding
	Description	NFX1-type zinc finger-containing protein 1	DNA damage-binding protein 1DDB p127 subunitDNA damage-binding protein aHBV X-associated protein 1UV-DDB 1UV-damaged DNA-binding factorUV-damaged DNA-binding protein 1XAP-1XPE-binding factordamage-specific DNA binding protein 1, 127kDaxeroderma
	Modification date	20200313	20200327
	UniProtAcc	.	DCAF8L2
	Ensembl transtripts involved in fusion gene	ENST00000371754, ENST00000469991, ENST00000371752, ENST00000396105,	ENST00000301764, ENST00000450997, ENST00000451943, ENST00000538470, ENST00000545930,
Fusion gene scores	* DoF score	7 X 8 X 4=224	10 X 12 X 5=600
	# samples	8	13
	** MAII score	log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/600*10)=-2.20645087746743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ZNFX1 [Title/Abstract] AND DDB1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ZNFX1(47879870)-DDB1(61081958), # samples:2
Anticipated loss of major functional domain due to fusion event.	ZNFX1-DDB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ZNFX1-DDB1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. ZNFX1-DDB1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DDB1	GO:0006511	ubiquitin-dependent protein catabolic process	11673459
Tgene	DDB1	GO:0016567	protein ubiquitination	26431207\|28886238
Tgene	DDB1	GO:0035518	histone H2A monoubiquitination	22334663
Tgene	DDB1	GO:0051702	interaction with symbiont	23137809
Tgene	DDB1	GO:0070914	UV-damage excision repair	22334663

Fusion gene breakpoints across ZNFX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DDB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-R6-A6XQ	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
ChimerDB4	ESCA	TCGA-R6-A6XQ	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-

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Fusion Gene ORF analysis for ZNFX1-DDB1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000371754	ENST00000301764	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
5CDS-intron	ENST00000371754	ENST00000450997	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
5CDS-intron	ENST00000371754	ENST00000451943	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
5CDS-intron	ENST00000371754	ENST00000538470	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
5CDS-5UTR	ENST00000371754	ENST00000545930	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
intron-3CDS	ENST00000469991	ENST00000301764	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
intron-intron	ENST00000469991	ENST00000450997	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
intron-intron	ENST00000469991	ENST00000451943	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
intron-intron	ENST00000469991	ENST00000538470	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
intron-5UTR	ENST00000469991	ENST00000545930	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
Frame-shift	ENST00000371752	ENST00000301764	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
5CDS-intron	ENST00000371752	ENST00000450997	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
5CDS-intron	ENST00000371752	ENST00000451943	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
5CDS-intron	ENST00000371752	ENST00000538470	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
5CDS-5UTR	ENST00000371752	ENST00000545930	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
In-frame	ENST00000396105	ENST00000301764	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
5CDS-intron	ENST00000396105	ENST00000450997	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
5CDS-intron	ENST00000396105	ENST00000451943	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
5CDS-intron	ENST00000396105	ENST00000538470	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-
5CDS-5UTR	ENST00000396105	ENST00000545930	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000371754	ZNFX1	chr20	47879870	-	ENST00000301764	DDB1	chr11	61081958	-	5453	2755	454	4767	1437
ENST00000396105	ZNFX1	chr20	47879870	-	ENST00000301764	DDB1	chr11	61081958	-	5246	2548	247	4560	1437

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000371754	ENST00000301764	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-	0.001132722	0.9988673
ENST00000396105	ENST00000301764	ZNFX1	chr20	47879870	-	DDB1	chr11	61081958	-	0.000913727	0.99908626

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Fusion Genomic Features for ZNFX1-DDB1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ZNFX1-DDB1

Go to
FGviewer for the breakpoints of chr20:47879870-chr11:61081958
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DDB1 DCAF8L2
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	631

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000371752

286_313

767.0

1919.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000396105

286_313

767.0

1919.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DDB1

chr20:47879870

chr11:61081958

ENST00000301764

709_1043

470.0

1141.0

Region

Note=WD repeat beta-propeller C

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000371752

1741_1820

767.0

1919.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000371752

886_967

767.0

1919.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000396105

1741_1820

767.0

1919.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000396105

886_967

767.0

1919.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000371752

812_819

767.0

1919.0

Compositional bias

Note=Poly-Glu

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000371752

839_842

767.0

1919.0

Compositional bias

Note=Poly-Glu

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000396105

812_819

767.0

1919.0

Compositional bias

Note=Poly-Glu

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000396105

839_842

767.0

1919.0

Compositional bias

Note=Poly-Glu

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000371752

1298_1320

767.0

1919.0

Zinc finger

Note=NF-X1-type 1

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000371752

1330_1346

767.0

1919.0

Zinc finger

Note=NF-X1-type 2

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000371752

1382_1400

767.0

1919.0

Zinc finger

Note=NF-X1-type 3

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000371752

1441_1463

767.0

1919.0

Zinc finger

Note=NF-X1-type 4

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000371752

1471_1488

767.0

1919.0

Zinc finger

Note=NF-X1-type 5

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000371752

1546_1564

767.0

1919.0

Zinc finger

Note=NF-X1-type 6

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000396105

1298_1320

767.0

1919.0

Zinc finger

Note=NF-X1-type 1

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000396105

1330_1346

767.0

1919.0

Zinc finger

Note=NF-X1-type 2

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000396105

1382_1400

767.0

1919.0

Zinc finger

Note=NF-X1-type 3

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000396105

1441_1463

767.0

1919.0

Zinc finger

Note=NF-X1-type 4

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000396105

1471_1488

767.0

1919.0

Zinc finger

Note=NF-X1-type 5

Hgene

ZNFX1

chr20:47879870

chr11:61081958

ENST00000396105

1546_1564

767.0

1919.0

Zinc finger

Note=NF-X1-type 6

Tgene

DDB1

chr20:47879870

chr11:61081958

ENST00000301764

13_356

470.0

1141.0

Region

Note=WD repeat beta-propeller A

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Fusion Gene Sequence for ZNFX1-DDB1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000371754_ENST00000301764_TCGA-R6-A6XQ_ZNFX1_chr20_47879870_-_DDB1_chr11_61081958_length(transcript)=5453nt_BP=2755nt
TTCCTCGCCATGTCGCGCTTCACACGCACCAAACCGCTCGACGGGTTCCCCTTCCTCTGGGGCCGGCTGAGGCCCGCAAAGGCCTTGGGC
GCAGTCATCTCCCGCCCCCCGCGGTCCGCTCCCCTCAGCCGCGCCCGCCTGAGCCCGCCGGCTCCGCCGCCGGGGGGAGCTGAGGTGACG
CCCTCCTCGAGGGCGGAGGCGCCGGCCGTGCCTGGGCCAGGCCCTCGTGCTCTCCACCCTGGGCCCCCGCCTCCTCCTTCTCCTCCTCTG
GGCCGCCCGCCCGGCTCCGCCCAGGGTCTGCGGGGAACGGAAACCGAAAGTGCGCGGCGCCGGGCGGGGCCACCGACCTGCCTGGGCCGA
AGCCCCAGCACTCGCCGGCGGCAGTGAAAGGACGCGCCGGAGCCGGTTTTCCAGATAACAGAAAGTAACGTGAAGGAATTCAGGTGACTC
AGACATGGAGGAGAGAAGACCTCATCTGGATGCCAGGCCCAGGAATTCCCATACCAACCACAGAGGCCCTGTGGATGGAGAGTTACCACC
AAGAGCTAGAAATCAGGCCAATAACCCACCAGCCAATGCTCTCCGAGGAGGAGCCAGCCACCCTGGAAGGCATCCTAGGGCCAACAACCA
TCCTGCTGCTTACTGGCAGAGGGAAGAGAGATTTAGGGCCATGGGCAGGAACCCACATCAAGGAAGGAGGAACCAGGAGGGGCATGCCAG
CGACGAAGCTAGAGACCAAAGACATGACCAGGAGAATGACACCAGGTGGAGAAATGGCAACCAGGACTGTAGGAACCGCAGACCACCATG
GTCCAATGACAACTTCCAGCAGTGGCGGACTCCCCACCAGAAGCCTACAGAACAGCCACAGCAGGCGAAGAAACTGGGCTACAAGTTCTT
AGAAAGTCTTCTGCAGAAAGACCCTTCTGAGGTGGTCATCACACTTGCCACAAGTTTAGGGCTGAAAGAGCTCCTTTCTCATTCTTCCAT
GAAATCTAACTTCCTTGAGCTCATCTGTCAGGTTCTTCGGAAGGCTTGTAGCTCCAAAATGGATCGCCAGAGTGTTCTCCATGTACTGGG
CATATTGAAAAACTCCAAATTTCTCAAAGTCTGCCTGCCTGCTTATGTGGTAGGGATGATCACTGAACCCATCCCTGACATCCGAAACCA
GTATCCAGAGCACATAAGCAACATCATCTCCCTCCTCCAGGACCTTGTAAGTGTCTTCCCTGCCAGCTCTGTGCAGGAAACTTCCATGCT
GGTTTCCCTCCTGCCAACCTCTCTTAATGCTCTGAGAGCCTCTGGTGTTGACATAGAAGAGGAAACGGAGAAGAACCTGGAAAAGGTACA
GACTATCATTGAACATCTGCAGGAAAAGAGGCGAGAGGGCACTTTGAGAGTGGATACCTACACTCTAGTGCAGCCTGAGGCAGAAGACCA
TGTTGAGAGCTACCGAACCATGCCCATTTACCCTACCTACAATGAAGTGCACTTGGATGAGAGGCCCTTCCTTCGCCCCAATATCATTTC
TGGAAAATACGACAGCACTGCTATCTATCTGGATACCCACTTCCGGCTCCTGCGAGAAGATTTCGTCAGACCTTTACGGGAAGGTATTTT
GGAACTTCTCCAAAGCTTTGAAGACCAGGGCCTGAGGAAGAGAAAGTTTGATGACATCCGAATCTACTTTGACACCAGGATTATCACCCC
CATGTGTTCATCATCAGGCATAGTCTACAAGGTGCAGTTTGACACAAAACCACTGAAGTTTGTTCGCTGGCAGAATTCCAAACGATTGCT
CTATGGGTCTTTGGTATGCATGTCCAAGGACAACTTCGAGACATTTCTTTTTGCCACCGTATCTAACAGGGAGCAGGAAGATCTCTGCCG
AGGAATTGTCCAGCTCTGCTTCAATGAGCAAAGCCAACAGCTGCTAGCAGAGGTCCAGCCCTCTGACTCTTTCCTCATGGTAGAGACAAC
TGCATACTTTGAGGCCTACAGGCACGTCCTGGAAGGACTCCAGGAGGTCCAGGAGGAAGATGTTCCCTTCCAGAGGAATATCGTGGAGTG
TAACTCTCATGTGAAGGAGCCAAGGTACTTGCTAATGGGGGGCAGATACGACTTTACCCCCTTAATAGAGAATCCTTCAGCCACTGGGGA
ATTTCTAAGAAATGTCGAGGGTTTGAGACATCCCAGAATTAATGTCTTAGATCCTGGCCAGTGGCCCTCAAAAGAAGCCCTGAAGCTGGA
TGACTCCCAGATGGAAGCCTTGCAGTTTGCTCTCACAAGGGAACTGGCTATTATTCAAGGACCTCCTGGAACAGGCAAAACCTATGTGGG
TCTAAAAATTGTTCAGGCCCTCCTAACCAACGAGTCTGTTTGGCAAATTAGCCTCCAGAAGTTCCCCATCTTGGTTGTGTGTTATACTAA
TCATGCTTTGGACCAGTTTCTGGAAGGCATCTACAATTGTCAGAAGACCAGCATTGTGCGGGTGGGTGGAAGGAGCAACAGTGAAATCCT
GAAGCAGTTCACCCTAAGGGAGCTGAGGAACAAGCGGGAATTCCGCCGCAACCTCCCCATGCACCTCCGAAGGGCCTACATGAGTATCAT
GACACAGATGAAGGAGTCAGAGCAAGAGCTTCATGAAGGAGCCAAGACCCTGGAGTGCACCATGCGTGGTGTCCTACGGGAACAGTACCT
GCAGAAGTACATCTCACCCCAGCACTGGGAAAGTCTCATGAATGGACCAGTGCAGATCACTTCAGCATCGGTGAGGTTGGTCTCTCAAGA
ACCCAAAGCTCTGGTCAGTGAATGGAAGGAGCCTCAGGCCAAGAACATCAGTGTGGCCTCCTGCAATAGCAGCCAGGTGGTGGTGGCTGT
AGGCAGGGCCCTCTACTATCTGCAGATCCATCCTCAGGAGCTCCGGCAGATCAGCCACACAGAGATGGAACATGAAGTGGCTTGCTTGGA
CATCACCCCATTAGGAGACAGCAATGGACTGTCCCCTCTTTGTGCCATTGGCCTCTGGACGGACATCTCGGCTCGTATCTTGAAGTTGCC
CTCTTTTGAACTACTGCACAAGGAGATGCTGGGTGGAGAGATCATTCCTCGCTCCATCCTGATGACCACCTTTGAGAGTAGCCATTACCT
CCTTTGTGCCTTGGGAGATGGAGCGCTTTTCTACTTTGGGCTCAACATTGAGACAGGTCTGTTGAGCGACCGTAAGAAGGTGACTTTGGG
CACCCAGCCCACCGTATTGAGGACTTTTCGTTCTCTTTCTACCACCAACGTCTTTGCTTGTTCTGACCGCCCCACTGTCATCTATAGCAG
CAACCACAAATTGGTCTTCTCAAATGTCAACCTCAAGGAAGTGAACTACATGTGTCCCCTCAATTCAGATGGCTATCCTGACAGCCTGGC
GCTGGCCAACAATAGCACCCTCACCATTGGCACCATCGATGAGATCCAGAAGCTGCACATTCGCACAGTTCCCCTCTATGAGTCTCCAAG
GAAGATCTGCTACCAGGAAGTGTCCCAGTGTTTCGGGGTCCTCTCCAGCCGCATTGAAGTCCAAGACACGAGTGGGGGCACGACAGCCTT
GAGGCCCAGCGCTAGCACCCAGGCTCTGTCCAGCAGTGTAAGCTCCAGCAAGCTGTTCTCCAGCAGCACTGCTCCTCATGAGACCTCCTT
TGGAGAAGAGGTGGAGGTGCACAACCTACTTATCATTGACCAACACACCTTTGAAGTGCTTCATGCCCACCAGTTTCTGCAGAATGAATA
TGCCCTCAGTCTGGTTTCCTGCAAGCTGGGCAAAGACCCCAACACTTACTTCATTGTGGGCACAGCAATGGTGTATCCTGAAGAGGCAGA
GCCCAAGCAGGGTCGCATTGTGGTCTTTCAGTATTCGGATGGAAAACTACAGACTGTGGCTGAAAAGGAAGTGAAAGGGGCCGTGTACTC
TATGGTGGAATTTAACGGGAAGCTGTTAGCCAGCATCAATAGCACGGTGCGGCTCTATGAGTGGACAACAGAGAAGGAGCTGCGCACTGA
GTGCAACCACTACAACAACATCATGGCCCTCTACCTGAAGACCAAGGGCGACTTCATCCTGGTGGGCGACCTTATGCGCTCAGTGCTGCT
GCTTGCCTACAAGCCCATGGAAGGAAACTTTGAAGAGATTGCTCGAGACTTTAATCCCAACTGGATGAGTGCTGTGGAAATCTTGGATGA
TGACAATTTTCTGGGGGCTGAAAATGCCTTTAACTTGTTTGTGTGTCAAAAGGATAGCGCTGCCACCACTGACGAGGAGCGGCAGCACCT
CCAGGAGGTTGGTCTTTTCCACCTGGGCGAGTTTGTCAATGTCTTTTGCCACGGCTCTCTGGTAATGCAGAATCTGGGTGAGACTTCCAC
CCCCACACAAGGCTCGGTGCTCTTCGGCACGGTCAACGGCATGATAGGGCTGGTGACCTCACTGTCAGAGAGCTGGTACAACCTCCTGCT
GGACATGCAGAATCGACTCAATAAAGTCATCAAAAGTGTGGGGAAGATCGAGCACTCCTTCTGGAGATCCTTTCACACCGAGCGGAAGAC
AGAACCAGCCACAGGTTTCATCGACGGTGACTTGATTGAGAGTTTCCTGGATATTAGCCGCCCCAAGATGCAGGAGGTGGTGGCAAACCT
ACAGTATGACGATGGCAGCGGTATGAAGCGAGAGGCCACTGCAGACGACCTCATCAAGGTTGTGGAGGAGCTAACTCGGATCCATTAGCC
AAGGGCAGGGGGCCCCTTTGCTGACCCTCCCCAAAGGCTTTGCCCTGCTGCCCTCCCCCTCCTCTCCACCATCGTCTTCTTGGCCATGGG
AGGCCTTTCCCTAAGCCAGCTGCCCCCAGAGCCACAGTTCCCCTATGTGGAAGTGGGGCGGGCTTCATAGAGACTTGGGAATGAGCTGAA
GGTGAAACATTTTCTCCCTGGATTTTTACCAGTCTCACATGATTCCAGCCATCACCTTAGACCACCAAGCCTTGATTGGTGTTGCCAGTT
GTCCTCCTTCCGGGGAAGGATTTTGCAGTTCTTTGGCTGAAAGGAAGCTGTGCGTGTGTGTGTGTGTATGTGTGTGTGTGTATGTGTATC
TCACACTCATGCATTGTCCTCTTTTTATTTAGATTGGCAGTGTAGGGAGTTGTGGGTAGTGGGGAAGAGGGTTAGGAGGGTTTCATTGTC
TGTGAAGTGAGACCTTCCTTTTACTTTTCTTCTATTGCCTCTGAGAGCATCAGGCCTAGAGGCCTGACTGCCAAGCCATGGGTAGCCTGG
GTGTAAAACCTGGAGATGGTGGATGATCCCCACGCCACAGCCCTTTTGTCTCTGCAAACTGCCTTCTTCGGAAAGAAGAAGGTGGGAGGA

>In-frame_ENST00000371754_ENST00000301764_TCGA-R6-A6XQ_ZNFX1_chr20_47879870_-_DDB1_chr11_61081958_length(amino acids)=1437AA_start in transcript=454_stop in transcript=4767
MEERRPHLDARPRNSHTNHRGPVDGELPPRARNQANNPPANALRGGASHPGRHPRANNHPAAYWQREERFRAMGRNPHQGRRNQEGHASD
EARDQRHDQENDTRWRNGNQDCRNRRPPWSNDNFQQWRTPHQKPTEQPQQAKKLGYKFLESLLQKDPSEVVITLATSLGLKELLSHSSMK
SNFLELICQVLRKACSSKMDRQSVLHVLGILKNSKFLKVCLPAYVVGMITEPIPDIRNQYPEHISNIISLLQDLVSVFPASSVQETSMLV
SLLPTSLNALRASGVDIEEETEKNLEKVQTIIEHLQEKRREGTLRVDTYTLVQPEAEDHVESYRTMPIYPTYNEVHLDERPFLRPNIISG
KYDSTAIYLDTHFRLLREDFVRPLREGILELLQSFEDQGLRKRKFDDIRIYFDTRIITPMCSSSGIVYKVQFDTKPLKFVRWQNSKRLLY
GSLVCMSKDNFETFLFATVSNREQEDLCRGIVQLCFNEQSQQLLAEVQPSDSFLMVETTAYFEAYRHVLEGLQEVQEEDVPFQRNIVECN
SHVKEPRYLLMGGRYDFTPLIENPSATGEFLRNVEGLRHPRINVLDPGQWPSKEALKLDDSQMEALQFALTRELAIIQGPPGTGKTYVGL
KIVQALLTNESVWQISLQKFPILVVCYTNHALDQFLEGIYNCQKTSIVRVGGRSNSEILKQFTLRELRNKREFRRNLPMHLRRAYMSIMT
QMKESEQELHEGAKTLECTMRGVLREQYLQKYISPQHWESLMNGPVQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQVVVAVG
RALYYLQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLL
CALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLAL
ANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHETSFG
EEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSM
VEFNGKLLASINSTVRLYEWTTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDD
NFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLLD

--------------------------------------------------------------
>In-frame_ENST00000396105_ENST00000301764_TCGA-R6-A6XQ_ZNFX1_chr20_47879870_-_DDB1_chr11_61081958_length(transcript)=5246nt_BP=2548nt
GTGCCTGGGCCAGGCCCTCGTGCTCTCCACCCTGGGCCCCCGCCTCCTCCTTCTCCTCCTCTGGGCCGCCCGCCCGGCTCCGCCCAGGGT
CTGCGGGGAACGGAAACCGAAAGTGCGCGGCGCCGGGCGGGGCCACCGACCTGCCTGGGCCGAAGCCCCAGCACTCGCCGGCGGCAGTGA
AAGGACGCGCCGGAGCCGGTTTTCCAGATAACAGAAAGTAACGTGAAGGAATTCAGGTGACTCAGACATGGAGGAGAGAAGACCTCATCT
GGATGCCAGGCCCAGGAATTCCCATACCAACCACAGAGGCCCTGTGGATGGAGAGTTACCACCAAGAGCTAGAAATCAGGCCAATAACCC
ACCAGCCAATGCTCTCCGAGGAGGAGCCAGCCACCCTGGAAGGCATCCTAGGGCCAACAACCATCCTGCTGCTTACTGGCAGAGGGAAGA
GAGATTTAGGGCCATGGGCAGGAACCCACATCAAGGAAGGAGGAACCAGGAGGGGCATGCCAGCGACGAAGCTAGAGACCAAAGACATGA
CCAGGAGAATGACACCAGGTGGAGAAATGGCAACCAGGACTGTAGGAACCGCAGACCACCATGGTCCAATGACAACTTCCAGCAGTGGCG
GACTCCCCACCAGAAGCCTACAGAACAGCCACAGCAGGCGAAGAAACTGGGCTACAAGTTCTTAGAAAGTCTTCTGCAGAAAGACCCTTC
TGAGGTGGTCATCACACTTGCCACAAGTTTAGGGCTGAAAGAGCTCCTTTCTCATTCTTCCATGAAATCTAACTTCCTTGAGCTCATCTG
TCAGGTTCTTCGGAAGGCTTGTAGCTCCAAAATGGATCGCCAGAGTGTTCTCCATGTACTGGGCATATTGAAAAACTCCAAATTTCTCAA
AGTCTGCCTGCCTGCTTATGTGGTAGGGATGATCACTGAACCCATCCCTGACATCCGAAACCAGTATCCAGAGCACATAAGCAACATCAT
CTCCCTCCTCCAGGACCTTGTAAGTGTCTTCCCTGCCAGCTCTGTGCAGGAAACTTCCATGCTGGTTTCCCTCCTGCCAACCTCTCTTAA
TGCTCTGAGAGCCTCTGGTGTTGACATAGAAGAGGAAACGGAGAAGAACCTGGAAAAGGTACAGACTATCATTGAACATCTGCAGGAAAA
GAGGCGAGAGGGCACTTTGAGAGTGGATACCTACACTCTAGTGCAGCCTGAGGCAGAAGACCATGTTGAGAGCTACCGAACCATGCCCAT
TTACCCTACCTACAATGAAGTGCACTTGGATGAGAGGCCCTTCCTTCGCCCCAATATCATTTCTGGAAAATACGACAGCACTGCTATCTA
TCTGGATACCCACTTCCGGCTCCTGCGAGAAGATTTCGTCAGACCTTTACGGGAAGGTATTTTGGAACTTCTCCAAAGCTTTGAAGACCA
GGGCCTGAGGAAGAGAAAGTTTGATGACATCCGAATCTACTTTGACACCAGGATTATCACCCCCATGTGTTCATCATCAGGCATAGTCTA
CAAGGTGCAGTTTGACACAAAACCACTGAAGTTTGTTCGCTGGCAGAATTCCAAACGATTGCTCTATGGGTCTTTGGTATGCATGTCCAA
GGACAACTTCGAGACATTTCTTTTTGCCACCGTATCTAACAGGGAGCAGGAAGATCTCTGCCGAGGAATTGTCCAGCTCTGCTTCAATGA
GCAAAGCCAACAGCTGCTAGCAGAGGTCCAGCCCTCTGACTCTTTCCTCATGGTAGAGACAACTGCATACTTTGAGGCCTACAGGCACGT
CCTGGAAGGACTCCAGGAGGTCCAGGAGGAAGATGTTCCCTTCCAGAGGAATATCGTGGAGTGTAACTCTCATGTGAAGGAGCCAAGGTA
CTTGCTAATGGGGGGCAGATACGACTTTACCCCCTTAATAGAGAATCCTTCAGCCACTGGGGAATTTCTAAGAAATGTCGAGGGTTTGAG
ACATCCCAGAATTAATGTCTTAGATCCTGGCCAGTGGCCCTCAAAAGAAGCCCTGAAGCTGGATGACTCCCAGATGGAAGCCTTGCAGTT
TGCTCTCACAAGGGAACTGGCTATTATTCAAGGACCTCCTGGAACAGGCAAAACCTATGTGGGTCTAAAAATTGTTCAGGCCCTCCTAAC
CAACGAGTCTGTTTGGCAAATTAGCCTCCAGAAGTTCCCCATCTTGGTTGTGTGTTATACTAATCATGCTTTGGACCAGTTTCTGGAAGG
CATCTACAATTGTCAGAAGACCAGCATTGTGCGGGTGGGTGGAAGGAGCAACAGTGAAATCCTGAAGCAGTTCACCCTAAGGGAGCTGAG
GAACAAGCGGGAATTCCGCCGCAACCTCCCCATGCACCTCCGAAGGGCCTACATGAGTATCATGACACAGATGAAGGAGTCAGAGCAAGA
GCTTCATGAAGGAGCCAAGACCCTGGAGTGCACCATGCGTGGTGTCCTACGGGAACAGTACCTGCAGAAGTACATCTCACCCCAGCACTG
GGAAAGTCTCATGAATGGACCAGTGCAGATCACTTCAGCATCGGTGAGGTTGGTCTCTCAAGAACCCAAAGCTCTGGTCAGTGAATGGAA
GGAGCCTCAGGCCAAGAACATCAGTGTGGCCTCCTGCAATAGCAGCCAGGTGGTGGTGGCTGTAGGCAGGGCCCTCTACTATCTGCAGAT
CCATCCTCAGGAGCTCCGGCAGATCAGCCACACAGAGATGGAACATGAAGTGGCTTGCTTGGACATCACCCCATTAGGAGACAGCAATGG
ACTGTCCCCTCTTTGTGCCATTGGCCTCTGGACGGACATCTCGGCTCGTATCTTGAAGTTGCCCTCTTTTGAACTACTGCACAAGGAGAT
GCTGGGTGGAGAGATCATTCCTCGCTCCATCCTGATGACCACCTTTGAGAGTAGCCATTACCTCCTTTGTGCCTTGGGAGATGGAGCGCT
TTTCTACTTTGGGCTCAACATTGAGACAGGTCTGTTGAGCGACCGTAAGAAGGTGACTTTGGGCACCCAGCCCACCGTATTGAGGACTTT
TCGTTCTCTTTCTACCACCAACGTCTTTGCTTGTTCTGACCGCCCCACTGTCATCTATAGCAGCAACCACAAATTGGTCTTCTCAAATGT
CAACCTCAAGGAAGTGAACTACATGTGTCCCCTCAATTCAGATGGCTATCCTGACAGCCTGGCGCTGGCCAACAATAGCACCCTCACCAT
TGGCACCATCGATGAGATCCAGAAGCTGCACATTCGCACAGTTCCCCTCTATGAGTCTCCAAGGAAGATCTGCTACCAGGAAGTGTCCCA
GTGTTTCGGGGTCCTCTCCAGCCGCATTGAAGTCCAAGACACGAGTGGGGGCACGACAGCCTTGAGGCCCAGCGCTAGCACCCAGGCTCT
GTCCAGCAGTGTAAGCTCCAGCAAGCTGTTCTCCAGCAGCACTGCTCCTCATGAGACCTCCTTTGGAGAAGAGGTGGAGGTGCACAACCT
ACTTATCATTGACCAACACACCTTTGAAGTGCTTCATGCCCACCAGTTTCTGCAGAATGAATATGCCCTCAGTCTGGTTTCCTGCAAGCT
GGGCAAAGACCCCAACACTTACTTCATTGTGGGCACAGCAATGGTGTATCCTGAAGAGGCAGAGCCCAAGCAGGGTCGCATTGTGGTCTT
TCAGTATTCGGATGGAAAACTACAGACTGTGGCTGAAAAGGAAGTGAAAGGGGCCGTGTACTCTATGGTGGAATTTAACGGGAAGCTGTT
AGCCAGCATCAATAGCACGGTGCGGCTCTATGAGTGGACAACAGAGAAGGAGCTGCGCACTGAGTGCAACCACTACAACAACATCATGGC
CCTCTACCTGAAGACCAAGGGCGACTTCATCCTGGTGGGCGACCTTATGCGCTCAGTGCTGCTGCTTGCCTACAAGCCCATGGAAGGAAA
CTTTGAAGAGATTGCTCGAGACTTTAATCCCAACTGGATGAGTGCTGTGGAAATCTTGGATGATGACAATTTTCTGGGGGCTGAAAATGC
CTTTAACTTGTTTGTGTGTCAAAAGGATAGCGCTGCCACCACTGACGAGGAGCGGCAGCACCTCCAGGAGGTTGGTCTTTTCCACCTGGG
CGAGTTTGTCAATGTCTTTTGCCACGGCTCTCTGGTAATGCAGAATCTGGGTGAGACTTCCACCCCCACACAAGGCTCGGTGCTCTTCGG
CACGGTCAACGGCATGATAGGGCTGGTGACCTCACTGTCAGAGAGCTGGTACAACCTCCTGCTGGACATGCAGAATCGACTCAATAAAGT
CATCAAAAGTGTGGGGAAGATCGAGCACTCCTTCTGGAGATCCTTTCACACCGAGCGGAAGACAGAACCAGCCACAGGTTTCATCGACGG
TGACTTGATTGAGAGTTTCCTGGATATTAGCCGCCCCAAGATGCAGGAGGTGGTGGCAAACCTACAGTATGACGATGGCAGCGGTATGAA
GCGAGAGGCCACTGCAGACGACCTCATCAAGGTTGTGGAGGAGCTAACTCGGATCCATTAGCCAAGGGCAGGGGGCCCCTTTGCTGACCC
TCCCCAAAGGCTTTGCCCTGCTGCCCTCCCCCTCCTCTCCACCATCGTCTTCTTGGCCATGGGAGGCCTTTCCCTAAGCCAGCTGCCCCC
AGAGCCACAGTTCCCCTATGTGGAAGTGGGGCGGGCTTCATAGAGACTTGGGAATGAGCTGAAGGTGAAACATTTTCTCCCTGGATTTTT
ACCAGTCTCACATGATTCCAGCCATCACCTTAGACCACCAAGCCTTGATTGGTGTTGCCAGTTGTCCTCCTTCCGGGGAAGGATTTTGCA
GTTCTTTGGCTGAAAGGAAGCTGTGCGTGTGTGTGTGTGTATGTGTGTGTGTGTATGTGTATCTCACACTCATGCATTGTCCTCTTTTTA
TTTAGATTGGCAGTGTAGGGAGTTGTGGGTAGTGGGGAAGAGGGTTAGGAGGGTTTCATTGTCTGTGAAGTGAGACCTTCCTTTTACTTT
TCTTCTATTGCCTCTGAGAGCATCAGGCCTAGAGGCCTGACTGCCAAGCCATGGGTAGCCTGGGTGTAAAACCTGGAGATGGTGGATGAT
CCCCACGCCACAGCCCTTTTGTCTCTGCAAACTGCCTTCTTCGGAAAGAAGAAGGTGGGAGGATGTGAATTGTTAGTTTCTGAGTTTTAC

>In-frame_ENST00000396105_ENST00000301764_TCGA-R6-A6XQ_ZNFX1_chr20_47879870_-_DDB1_chr11_61081958_length(amino acids)=1437AA_start in transcript=247_stop in transcript=4560
MEERRPHLDARPRNSHTNHRGPVDGELPPRARNQANNPPANALRGGASHPGRHPRANNHPAAYWQREERFRAMGRNPHQGRRNQEGHASD
EARDQRHDQENDTRWRNGNQDCRNRRPPWSNDNFQQWRTPHQKPTEQPQQAKKLGYKFLESLLQKDPSEVVITLATSLGLKELLSHSSMK
SNFLELICQVLRKACSSKMDRQSVLHVLGILKNSKFLKVCLPAYVVGMITEPIPDIRNQYPEHISNIISLLQDLVSVFPASSVQETSMLV
SLLPTSLNALRASGVDIEEETEKNLEKVQTIIEHLQEKRREGTLRVDTYTLVQPEAEDHVESYRTMPIYPTYNEVHLDERPFLRPNIISG
KYDSTAIYLDTHFRLLREDFVRPLREGILELLQSFEDQGLRKRKFDDIRIYFDTRIITPMCSSSGIVYKVQFDTKPLKFVRWQNSKRLLY
GSLVCMSKDNFETFLFATVSNREQEDLCRGIVQLCFNEQSQQLLAEVQPSDSFLMVETTAYFEAYRHVLEGLQEVQEEDVPFQRNIVECN
SHVKEPRYLLMGGRYDFTPLIENPSATGEFLRNVEGLRHPRINVLDPGQWPSKEALKLDDSQMEALQFALTRELAIIQGPPGTGKTYVGL
KIVQALLTNESVWQISLQKFPILVVCYTNHALDQFLEGIYNCQKTSIVRVGGRSNSEILKQFTLRELRNKREFRRNLPMHLRRAYMSIMT
QMKESEQELHEGAKTLECTMRGVLREQYLQKYISPQHWESLMNGPVQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQVVVAVG
RALYYLQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLL
CALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLAL
ANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHETSFG
EEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSM
VEFNGKLLASINSTVRLYEWTTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDD
NFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLLD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ZNFX1-DDB1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	DDB1	chr20:47879870	chr11:61081958	ENST00000301764		11	27	771_1140	470.0	1141.0	CDT1 and CUL4A

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	DDB1	chr20:47879870	chr11:61081958	ENST00000301764		11	27	2_768	470.0	1141.0	CDT1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ZNFX1-DDB1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ZNFX1-DDB1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	DDB1	C0019193	Hepatitis, Toxic	1	CTD_human
Tgene	DDB1	C0024623	Malignant neoplasm of stomach	1	CTD_human
Tgene	DDB1	C0038356	Stomach Neoplasms	1	CTD_human
Tgene	DDB1	C0235874	Disease Exacerbation	1	CTD_human
Tgene	DDB1	C0860207	Drug-Induced Liver Disease	1	CTD_human
Tgene	DDB1	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Tgene	DDB1	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Tgene	DDB1	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Tgene	DDB1	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Tgene	DDB1	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human