Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BRD8-HLA-DRA (FusionGDB2 ID:10273)

Fusion Gene Summary for BRD8-HLA-DRA

Fusion gene summary

Fusion gene information	Fusion gene name: BRD8-HLA-DRA
	Fusion gene ID: 10273
		Hgene	Tgene
	Gene symbol	BRD8	HLA-DRA
	Gene ID	10902	3122
	Gene name	bromodomain containing 8	major histocompatibility complex, class II, DR alpha
	Synonyms	SMAP\|SMAP2\|p120	HLA-DRA1
	Cytomap	5q31.2	6p21.32
	Type of gene	protein-coding	protein-coding
	Description	bromodomain-containing protein 8skeletal muscle abundant protein 2thyroid hormone receptor coactivating protein of 120 kDatrCP120	HLA class II histocompatibility antigen, DR alpha chainMHC class II antigen DRAhistocompatibility antigen HLA-DR alpha
	Modification date	20200313	20200313
	UniProtAcc	Q9H0E9	P01903
	Ensembl transtripts involved in fusion gene	ENST00000254900, ENST00000230901, ENST00000402931, ENST00000411594, ENST00000455658, ENST00000515014,	ENST00000395388, ENST00000374982, ENST00000383127, ENST00000459705, ENST00000434866, ENST00000416883, ENST00000481943, ENST00000411505, ENST00000414698, ENST00000546379, ENST00000493431, ENST00000418111, ENST00000383259, ENST00000551750, ENST00000461633, ENST00000383258, ENST00000442960, ENST00000549531, ENST00000482781, ENST00000415767, ENST00000411524, ENST00000553193, ENST00000498597, ENST00000427753,
Fusion gene scores	* DoF score	5 X 5 X 3=75	8 X 7 X 2=112
	# samples	5	8
	** MAII score	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/112*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: BRD8 [Title/Abstract] AND HLA-DRA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BRD8(137492769)-HLA-DRA(32410431), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BRD8	GO:0043967	histone H4 acetylation	14966270
Hgene	BRD8	GO:0043968	histone H2A acetylation	14966270
Tgene	HLA-DRA	GO:0002503	peptide antigen assembly with MHC class II protein complex	1448172\|7606781\|22733780
Tgene	HLA-DRA	GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	21502329

Fusion gene breakpoints across BRD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HLA-DRA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AI335540	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-

Top

Fusion Gene ORF analysis for BRD8-HLA-DRA

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000254900	ENST00000395388	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-3CDS	ENST00000254900	ENST00000374982	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000383127	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000459705	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000434866	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000416883	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000481943	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000411505	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000414698	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000546379	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000493431	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000418111	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000383259	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000551750	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000461633	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000383258	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000442960	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000549531	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000482781	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000415767	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000411524	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000553193	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000498597	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000254900	ENST00000427753	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-3CDS	ENST00000230901	ENST00000395388	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-3CDS	ENST00000230901	ENST00000374982	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000383127	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000459705	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000434866	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000416883	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000481943	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000411505	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000414698	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000546379	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000493431	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000418111	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000383259	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000551750	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000461633	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000383258	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000442960	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000549531	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000482781	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000415767	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000411524	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000553193	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000498597	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000230901	ENST00000427753	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-3CDS	ENST00000402931	ENST00000395388	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-3CDS	ENST00000402931	ENST00000374982	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000383127	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000459705	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000434866	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000416883	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000481943	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000411505	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000414698	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000546379	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000493431	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000418111	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000383259	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000551750	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000461633	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000383258	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000442960	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000549531	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000482781	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000415767	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000411524	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000553193	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000498597	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000402931	ENST00000427753	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-3CDS	ENST00000411594	ENST00000395388	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-3CDS	ENST00000411594	ENST00000374982	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000383127	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000459705	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000434866	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000416883	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000481943	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000411505	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000414698	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000546379	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000493431	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000418111	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000383259	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000551750	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000461633	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000383258	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000442960	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000549531	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000482781	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000415767	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000411524	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000553193	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000498597	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000411594	ENST00000427753	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-3CDS	ENST00000455658	ENST00000395388	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-3CDS	ENST00000455658	ENST00000374982	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000383127	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000459705	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000434866	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000416883	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000481943	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000411505	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000414698	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000546379	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000493431	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000418111	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000383259	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000551750	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000461633	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000383258	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000442960	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000549531	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000482781	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000415767	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000411524	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000553193	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000498597	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000455658	ENST00000427753	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-3CDS	ENST00000515014	ENST00000395388	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-3CDS	ENST00000515014	ENST00000374982	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000383127	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000459705	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000434866	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000416883	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000481943	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000411505	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000414698	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000546379	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000493431	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000418111	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000383259	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000551750	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000461633	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000383258	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000442960	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000549531	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000482781	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000415767	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000411524	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000553193	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000498597	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-
intron-intron	ENST00000515014	ENST00000427753	BRD8	chr5	137492769	+	HLA-DRA	chr6	32410431	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for BRD8-HLA-DRA

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for BRD8-HLA-DRA

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
BRD8 Q9H0E9	HLA-DRA P01903
FUNCTION: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. {ECO:0000269\|PubMed:10517671, ECO:0000269\|PubMed:14966270, ECO:0000269\|PubMed:24463511}.	FUNCTION: An alpha chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the beta chain HLA-DRB, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DR-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells (PubMed:29884618, PubMed:17334368, PubMed:8145819, PubMed:15322540, PubMed:22327072, PubMed:27591323, PubMed:31495665, PubMed:15265931, PubMed:9075930, PubMed:24190431). Typically presents extracellular peptide antigens of 10 to 30 amino acids that arise from proteolysis of endocytosed antigens in lysosomes (PubMed:8145819). In the tumor microenvironment, presents antigenic peptides that are primarily generated in tumor-resident APCs likely via phagocytosis of apoptotic tumor cells or macropinocytosis of secreted tumor proteins (PubMed:31495665). Presents peptides derived from intracellular proteins that are trapped in autolysosomes after macroautophagy, a mechanism especially relevant for T cell selection in the thymus and central immune tolerance (PubMed:17182262, PubMed:23783831). The selection of the immunodominant epitopes follows two processing modes: 'bind first, cut/trim later' for pathogen-derived antigenic peptides and 'cut first, bind later' for autoantigens/self-peptides (PubMed:25413013). The anchor residue at position 1 of the peptide N-terminus, usually a large hydrophobic residue, is essential for high affinity interaction with MHCII molecules (PubMed:8145819). {ECO:0000269\|PubMed:15265931, ECO:0000269\|PubMed:15322540, ECO:0000269\|PubMed:17182262, ECO:0000269\|PubMed:17334368, ECO:0000269\|PubMed:22327072, ECO:0000269\|PubMed:23783831, ECO:0000269\|PubMed:24190431, ECO:0000269\|PubMed:25413013, ECO:0000269\|PubMed:27591323, ECO:0000269\|PubMed:29884618, ECO:0000269\|PubMed:31495665, ECO:0000269\|PubMed:8145819, ECO:0000269\|PubMed:9075930}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for BRD8-HLA-DRA

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for BRD8-HLA-DRA

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BRD8-HLA-DRA

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BRD8-HLA-DRA

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	BRD8	C0014175	Endometriosis	1	CTD_human
Hgene	BRD8	C0269102	Endometrioma	1	CTD_human
Tgene	HLA-DRA	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Tgene	HLA-DRA	C0026769	Multiple Sclerosis	1	CTD_human
Tgene	HLA-DRA	C0030567	Parkinson Disease	1	CTD_human
Tgene	HLA-DRA	C0036981	Endotoxic shock	1	CTD_human
Tgene	HLA-DRA	C0036983	Septic Shock	1	CTD_human
Tgene	HLA-DRA	C0600327	Toxic Shock Syndrome	1	CTD_human
Tgene	HLA-DRA	C0751324	Multiple Sclerosis, Acute Fulminating	1	CTD_human