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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:BRSK1-HSPBP1 (FusionGDB2 ID:10388) |
Fusion Gene Summary for BRSK1-HSPBP1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: BRSK1-HSPBP1 | Fusion gene ID: 10388 | Hgene | Tgene | Gene symbol | BRSK1 | HSPBP1 | Gene ID | 84446 | 23640 |
Gene name | BR serine/threonine kinase 1 | HSPA (Hsp70) binding protein 1 | |
Synonyms | hSAD1 | FES1 | |
Cytomap | 19q13.42 | 19q13.42 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase BRSK1BR serine/threonine-protein kinase 1SAD1 homologSAD1 kinaseSadB kinase short isoformbrain-selective kinase 1brain-specific serine/threonine-protein kinase 1protein kinase SAD1Aserine/threonine-protein kinase SA | hsp70-binding protein 1HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1heat shock protein-binding protein 1hsp70 interacting protein | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q8TDC3 | Q9NZL4 | |
Ensembl transtripts involved in fusion gene | ENST00000590333, ENST00000309383, ENST00000585418, ENST00000326848, ENST00000588584, | ENST00000255631, ENST00000433386, ENST00000376343, ENST00000587922, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 4 X 4 X 3=48 |
# samples | 4 | 4 | |
** MAII score | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: BRSK1 [Title/Abstract] AND HSPBP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | BRSK1(55795946)-HSPBP1(55777654), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | BRSK1 | GO:0000086 | G2/M transition of mitotic cell cycle | 15150265 |
Hgene | BRSK1 | GO:0006468 | protein phosphorylation | 15150265 |
Hgene | BRSK1 | GO:0006974 | cellular response to DNA damage stimulus | 15150265 |
Hgene | BRSK1 | GO:0007095 | mitotic G2 DNA damage checkpoint | 15150265 |
Hgene | BRSK1 | GO:0009411 | response to UV | 15150265 |
Hgene | BRSK1 | GO:0010212 | response to ionizing radiation | 15150265 |
Hgene | BRSK1 | GO:0018105 | peptidyl-serine phosphorylation | 15150265 |
Tgene | HSPBP1 | GO:0031398 | positive regulation of protein ubiquitination | 16831871 |
Tgene | HSPBP1 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 16831871 |
Fusion gene breakpoints across BRSK1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across HSPBP1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-AO-A03V-01A | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
ChimerDB4 | BRCA | TCGA-AO-A03V | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
ChimerDB4 | BRCA | TCGA-AO-A03V-01A | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
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Fusion Gene ORF analysis for BRSK1-HSPBP1 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000590333 | ENST00000255631 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
In-frame | ENST00000590333 | ENST00000433386 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
5CDS-intron | ENST00000590333 | ENST00000376343 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
5CDS-intron | ENST00000590333 | ENST00000587922 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
In-frame | ENST00000309383 | ENST00000255631 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
In-frame | ENST00000309383 | ENST00000433386 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
5CDS-intron | ENST00000309383 | ENST00000376343 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
5CDS-intron | ENST00000309383 | ENST00000587922 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
In-frame | ENST00000585418 | ENST00000255631 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
In-frame | ENST00000585418 | ENST00000433386 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
5CDS-intron | ENST00000585418 | ENST00000376343 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
5CDS-intron | ENST00000585418 | ENST00000587922 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-3CDS | ENST00000326848 | ENST00000255631 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-3CDS | ENST00000326848 | ENST00000433386 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-intron | ENST00000326848 | ENST00000376343 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-intron | ENST00000326848 | ENST00000587922 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-3CDS | ENST00000588584 | ENST00000255631 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-3CDS | ENST00000588584 | ENST00000433386 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-intron | ENST00000588584 | ENST00000376343 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
intron-intron | ENST00000588584 | ENST00000587922 | BRSK1 | chr19 | 55795946 | + | HSPBP1 | chr19 | 55777654 | - |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for BRSK1-HSPBP1 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for BRSK1-HSPBP1 |
Go to FGviewer for the breakpoints of chr19:55795946-chr19:55777654 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
BRSK1 | HSPBP1 |
FUNCTION: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}. | FUNCTION: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. {ECO:0000269|PubMed:10786638, ECO:0000269|PubMed:12651857, ECO:0000269|PubMed:15215316, ECO:0000269|PubMed:21247889, ECO:0000269|PubMed:9830037}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000309383 | + | 1 | 19 | 40_48 | 45.333333333333336 | 779.0 | Nucleotide binding | ATP |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000585418 | + | 1 | 10 | 40_48 | 45.333333333333336 | 344.0 | Nucleotide binding | ATP |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000590333 | + | 3 | 21 | 40_48 | 61.333333333333336 | 795.0 | Nucleotide binding | ATP |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000255631 | 4 | 9 | 220_259 | 213.33333333333334 | 360.0 | Repeat | Note=ARM 3 | |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000255631 | 4 | 9 | 262_301 | 213.33333333333334 | 360.0 | Repeat | Note=ARM 4 | |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000433386 | 3 | 8 | 220_259 | 213.33333333333334 | 360.0 | Repeat | Note=ARM 3 | |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000433386 | 3 | 8 | 262_301 | 213.33333333333334 | 360.0 | Repeat | Note=ARM 4 | |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000587922 | 2 | 7 | 220_259 | 213.33333333333334 | 360.0 | Repeat | Note=ARM 3 | |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000587922 | 2 | 7 | 262_301 | 213.33333333333334 | 360.0 | Repeat | Note=ARM 4 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000309383 | + | 1 | 19 | 492_540 | 45.333333333333336 | 779.0 | Compositional bias | Note=Pro-rich |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000585418 | + | 1 | 10 | 492_540 | 45.333333333333336 | 344.0 | Compositional bias | Note=Pro-rich |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000590333 | + | 3 | 21 | 492_540 | 61.333333333333336 | 795.0 | Compositional bias | Note=Pro-rich |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000309383 | + | 1 | 19 | 314_356 | 45.333333333333336 | 779.0 | Domain | UBA |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000309383 | + | 1 | 19 | 34_285 | 45.333333333333336 | 779.0 | Domain | Protein kinase |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000585418 | + | 1 | 10 | 314_356 | 45.333333333333336 | 344.0 | Domain | UBA |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000585418 | + | 1 | 10 | 34_285 | 45.333333333333336 | 344.0 | Domain | Protein kinase |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000590333 | + | 3 | 21 | 314_356 | 61.333333333333336 | 795.0 | Domain | UBA |
Hgene | BRSK1 | chr19:55795946 | chr19:55777654 | ENST00000590333 | + | 3 | 21 | 34_285 | 61.333333333333336 | 795.0 | Domain | Protein kinase |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000255631 | 4 | 9 | 21_37 | 213.33333333333334 | 360.0 | Compositional bias | Note=Gly-rich | |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000433386 | 3 | 8 | 21_37 | 213.33333333333334 | 360.0 | Compositional bias | Note=Gly-rich | |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000587922 | 2 | 7 | 21_37 | 213.33333333333334 | 360.0 | Compositional bias | Note=Gly-rich | |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000255631 | 4 | 9 | 132_174 | 213.33333333333334 | 360.0 | Repeat | Note=ARM 1 | |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000255631 | 4 | 9 | 177_217 | 213.33333333333334 | 360.0 | Repeat | Note=ARM 2 | |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000433386 | 3 | 8 | 132_174 | 213.33333333333334 | 360.0 | Repeat | Note=ARM 1 | |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000433386 | 3 | 8 | 177_217 | 213.33333333333334 | 360.0 | Repeat | Note=ARM 2 | |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000587922 | 2 | 7 | 132_174 | 213.33333333333334 | 360.0 | Repeat | Note=ARM 1 | |
Tgene | HSPBP1 | chr19:55795946 | chr19:55777654 | ENST00000587922 | 2 | 7 | 177_217 | 213.33333333333334 | 360.0 | Repeat | Note=ARM 2 |
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Fusion Gene Sequence for BRSK1-HSPBP1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for BRSK1-HSPBP1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for BRSK1-HSPBP1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for BRSK1-HSPBP1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |