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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C10orf11-MYO1D (FusionGDB2 ID:10677)

Fusion Gene Summary for C10orf11-MYO1D

check button Fusion gene summary
Fusion gene informationFusion gene name: C10orf11-MYO1D
Fusion gene ID: 10677
HgeneTgene
Gene symbol

C10orf11

MYO1D

Gene ID

83938

4642

Gene nameleucine rich melanocyte differentiation associatedmyosin ID
SynonymsC10orf11|CDA017PPP1R108|myr4
Cytomap

10q22.2-q22.3

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich melanocyte differentiation-associated proteinleucine-rich repeat-containing protein C10orf11unconventional myosin-Idmyosin-I gammaprotein phosphatase 1, regulatory subunit 108
Modification date2020031320200313
UniProtAcc.

O94832

Ensembl transtripts involved in fusion geneENST00000593699, ENST00000372499, 
ENST00000496424, 		ENST00000318217, 
ENST00000394649, ENST00000579584, 
ENST00000584232, ENST00000583621, 
Fusion gene scores* DoF score28 X 20 X 9=504028 X 20 X 9=5040
# samples 3229
** MAII scorelog2(32/5040*10)=-3.97727992349992
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/5040*10)=-4.11929892837234
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C10orf11 [Title/Abstract] AND MYO1D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC10orf11(77818541)-MYO1D(30821933), # samples:3
Anticipated loss of major functional domain due to fusion event.C10orf11-MYO1D seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMYO1D

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across C10orf11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MYO1D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2288-01AC10orf11chr10

77818541

+MYO1Dchr17

30821933

-
ChimerDB4OVTCGA-24-2288C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
ChimerDB4OVTCGA-24-2288-01AC10orf11chr10

77818541

+MYO1Dchr17

30821933

-


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Fusion Gene ORF analysis for C10orf11-MYO1D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000593699ENST00000318217C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
3UTR-3CDSENST00000593699ENST00000394649C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
3UTR-intronENST00000593699ENST00000579584C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
3UTR-intronENST00000593699ENST00000584232C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
3UTR-intronENST00000593699ENST00000583621C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
In-frameENST00000372499ENST00000318217C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
Frame-shiftENST00000372499ENST00000394649C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
5CDS-intronENST00000372499ENST00000579584C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
5CDS-intronENST00000372499ENST00000584232C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
5CDS-intronENST00000372499ENST00000583621C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
intron-3CDSENST00000496424ENST00000318217C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
intron-3CDSENST00000496424ENST00000394649C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
intron-intronENST00000496424ENST00000579584C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
intron-intronENST00000496424ENST00000584232C10orf11chr10

77818541

+MYO1Dchr17

30821933

-
intron-intronENST00000496424ENST00000583621C10orf11chr10

77818541

+MYO1Dchr17

30821933

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372499C10orf11chr1077818541+ENST00000318217MYO1Dchr1730821933-3041647215649144

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372499ENST00000318217C10orf11chr1077818541+MYO1Dchr1730821933-0.0112564320.98874354

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Fusion Genomic Features for C10orf11-MYO1D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C10orf11-MYO1D


check button Go to

FGviewer for the breakpoints of chr10:77818541-chr17:30821933

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MYO1D

O94832

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity). {ECO:0000250|UniProtKB:F1PRN2, ECO:0000250|UniProtKB:Q63357}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC10orf11chr10:77818541chr17:30821933ENST00000372499+4696_134144.0199.0DomainNote=LRRCT
HgeneC10orf11chr10:77818541chr17:30821933ENST00000372499+4626_47144.0199.0RepeatNote=LRR 2
HgeneC10orf11chr10:77818541chr17:30821933ENST00000372499+462_22144.0199.0RepeatNote=LRR 1
HgeneC10orf11chr10:77818541chr17:30821933ENST00000372499+4648_69144.0199.0RepeatNote=LRR 3
HgeneC10orf11chr10:77818541chr17:30821933ENST00000372499+4675_95144.0199.0RepeatNote=LRR 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYO1Dchr10:77818541chr17:30821933ENST000003182172022699_719954.66666666666661007.0DomainIQ 1
TgeneMYO1Dchr10:77818541chr17:30821933ENST000003182172022721_741954.66666666666661007.0DomainIQ 2
TgeneMYO1Dchr10:77818541chr17:30821933ENST000003182172022812_1005954.66666666666661007.0DomainTH1
TgeneMYO1Dchr10:77818541chr17:30821933ENST0000031821720229_695954.66666666666661007.0DomainMyosin motor
TgeneMYO1Dchr10:77818541chr17:30821933ENST000003182172022102_109954.66666666666661007.0Nucleotide bindingATP
TgeneMYO1Dchr10:77818541chr17:30821933ENST000003182172022572_594954.66666666666661007.0RegionActin-binding


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Fusion Gene Sequence for C10orf11-MYO1D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000372499_ENST00000318217_TCGA-24-2288-01A_C10orf11_chr10_77818541_+_MYO1D_chr17_30821933_length(transcript)=3041nt_BP=647nt
GTTGAAGAAAGAGGATCTGGCTGAAAGACCCGCAACTTTCACTTGTTGAGAACCTTTAGCCAGCGCCGGCGTGCATGTGTTTTAGTTTTA
TTCTTTTTCCCTTGCCCCCAAAGCCGTGGAGTACCTGCTGTTGCTCTCATGCCTCTTGCCAACAGTGGCATCTGCTCAGTGTAGCCATCA
AGAATTTGAATGTCAATATCTTTGCCTTGAAATGAATGGAAAAGTATTTGTCACTCAGCGGCAATCATTCTTCAAATAAAAGGTCACTGG
AAGGACTGAGCGCATTCAGGAGCCTGGAGGAACTCATCTTGGACAACAATCAGCTGGGGGACGACCTTGTGTTGCCAGGGTTACCCAGAC
TGCATACCTTAACCCTCAACAAGAACCGAATCACTGATTTGGAGAACCTGCTGGATCACTTGGCAGAAGTGACACCAGCTCTGGAGTACC
TCAGTCTGCTGGGCAACGTGGCCTGTCCCAACGAGCTGGTCAGCTTGGAAAAGGATGAGGAAGACTACAAGAGATACAGATGCTTTGTTC
TGTACAAGCTGCCCAACTTGAAATTTCTGGATGCCCAGAAAGTAACCAGACAAGAACGAGAGGAGGCGTTGGTCAGAGGAGTCTTCATGA
AGGTGGTGAAGCCCAAGTGAGAAGCGCCACCTTCAAGTGAACGTCACCAACCCAGTACAGTGCAGCCTGCACGGGAAGAAGTGCACCGTC
TCCGTGGAGACGCGGCTCAACCAGCCCCAGCCCGACTTCACCAAGAATCGCTCGGGCTTCATCCTCAGCGTGCCCGGGAACTGACGCCCC
GCGGAGGCCTGGCCCGGAGCCCGGCCACACTCCGAGTCCTGGGTCCCAGTCCAGCTGCTGCCTCCCAACCCATGCCCGCTAGAAACCTGC
TGCGAGGGCCCCTCCCAGAGGAGCCCCGCCCCTGTAAGATTTCCTTCCTGGTTTTCTGCCTTTGGTATCATCTTCCTCTGTCCTTACTGT
CCACGGTCCCTGTTCAATAAGCCAAAGACCCTGGTGCCCCGCCCAGACCCCTGGGCTGACGTCCAGACCAATCTCACCCCAGAGGCAACT
GGATGGTGCCTTTAGTTGGTGCGGATGCCCCGTGGCCAGGTCAAGTCAGAGCACCTGGACAGGTGTCCTCCCTGCTGCTGACCCTGCAGA
GGGAAGGGGTGGGGATGCAGGACCCCACTCTGCGGGAGCCCCATAGCCACCTCTCTTGCCCAAGGTGAGCCAGCCCTGGGGACCCAGCTC
AGGGAGGCTCTGCTCAGAGTTCGGCGGACCCACCCCAACCCAACTCCCAGCCGCCAGCCAAAGCCACTGGGTGAGCAGAGTCACCCACAG
GGCCAGCCCCTCAGCCAGGAGCCAGTGGCAGGAGCGGAACAGCCCATCCAGCAGAGTGAGTCCATCCTTCCCAGGTTCTCCCCTGGGAGA
CTCCCTTTGCCACCAAGGCCCCCACCAGGGCCTCTGACCACCGCTCTGGAGAGGACAGTGTGGCATGCTCCAAGGATCATCTTACTTAAC
TCGCAGCCTGTGGCTGTGGTCCTCTTATAGATACTTTCACCGTTTGCAGGGTTGCTAATCAGATACCTGCTGTCACCACACTTGGGTCAG
GAACCCTAATGAGAACGGGGAGCTGCCAGGGTGAGGGCAGCCCTCAGGGTCGGCCGCTTTCCCTCTGGACCACCTCCCGCTGCGTTTCCT
ACTCAGAGAAACAGCAAGGGCGGGGTCAAGACACGGGATGACGGGAAGCAGGAAGCGGGGCAGCAGCACAGCGTGGGGTCCTGGCACTGC
AGGCCAGGCCAGGATGCCCACCCCGCCCTCTACACGGCCCCTTGGGGCCTGCGCCCGTGAAACTGGTGCCAGGGAGCACTGCCAGCTTGC
CAGTTTCTGCCCAGCAAAAGCACGTATGCTTCAGGGGCCTTCTGAGACCACCTTCCCCACTGAGCCCCAGCTGCTGAGAAGGCCTTGAGG
GAAGTAGAGGCTGGGAGCAAATGCCCCATGCGGTGAGAGGATGAGGGGAGCCTACGCCTCAGGCATGTGGTGAGAGGATGAGGGGGAGGG
AGCCAACGCCTCAGGTGGAGTGGGCAGAGGTGCAAGAGAGGGATGTACTGAAGCTTCTTCCCGTCCTGCCACAGACACTTCTCCTGCCTT
CCCACCCTGACCCGGCAGAACCCACCAAGTGCCTGTGTGCAGCCTCCTGTGCCTCACCCAGGGCCTGACCCCAGAGTGGTCCCAACAACC
CGGTCTCATGCCCACTCCCCATCCCTGCTTCCCAAAAATTGCACTGTGTGCAGTTTGCAACAAAGAATCCCGCTGGCATCCTGTCCTTGG
GAACCCTTTCTCATTCTCCAAGCCTGGTCAGCTGCCTGCACAGGCAGAGGTGCCCTCAGCCCAGATTAGCAACACTCATAGTTTTGCCAA
TTACCAGTAGACACTAGTGGAACCATCTAACTGGAACTTCCTCTCTCCTTCCACTTATTTCCTCAAACTTGTTGCTTTACACTAGACACA
TGCAAATGTATGTTTTAAACACACCAAAACAGATCATGCCAAATGAGTTGCCTGTCAAAGGCTGGAGGGCAGGAGGAGGGCCTGGGTTTG
GGTTCTTTCCTCCCAGCCTTTGGATGGTGCCTTGGGCCCCTTAGCCCCAGCGCCAGGGCCTCCCAGCTGAGGCCACAGGACAAGCACTTT
TTTATGATGTACTAAAAGCCACAGTATGTGGCAACTGCAAAAGGATCAGGAATTTAGGGTATGATCTCGGTCACGTGTCCCGGGCGCTGA
GGGGAAAGGAAGCGGGCATGATTGTAGACAATGAGGGGGTTCTCTTGATGTAATGAAATGCAATTTTATGGTTTGGTGCAAAAACTCCTA
TTTTCCAGTAAATTAACTTTATTTCTAAAGCATATTTTGATTTGCCATCAAGAGCAATAAAGCATTAAATCTTATTTTTAAAGGTGTTCT

>In-frame_ENST00000372499_ENST00000318217_TCGA-24-2288-01A_C10orf11_chr10_77818541_+_MYO1D_chr17_30821933_length(amino acids)=144AA_start in transcript=215_stop in transcript=649
MEKYLSLSGNHSSNKRSLEGLSAFRSLEELILDNNQLGDDLVLPGLPRLHTLTLNKNRITDLENLLDHLAEVTPALEYLSLLGNVACPNE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C10orf11-MYO1D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C10orf11-MYO1D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C10orf11-MYO1D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMYO1DC0004352Autistic Disorder1CTD_human