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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C11orf80-FADS1 (FusionGDB2 ID:10820)

Fusion Gene Summary for C11orf80-FADS1

check button Fusion gene summary
Fusion gene informationFusion gene name: C11orf80-FADS1
Fusion gene ID: 10820
HgeneTgene
Gene symbol

C11orf80

FADS1

Gene ID

79703

4593

Gene namechromosome 11 open reading frame 80muscle associated receptor tyrosine kinase
SynonymsHYDM4|TOP6BL|TOPOVIBLCMS9|FADS|FADS1
Cytomap

11q13.2

9q31.3

Type of geneprotein-codingprotein-coding
Descriptiontype 2 DNA topoisomerase 6 subunit B-liketype 2 DNA topoisomerase VI subunit B-likemuscle, skeletal receptor tyrosine-protein kinasemuscle, skeletal, receptor tyrosine kinasemuscle-specific kinase receptormuscle-specific tyrosine-protein kinase receptor
Modification date2020031320200313
UniProtAcc.

O60427

Ensembl transtripts involved in fusion geneENST00000346672, ENST00000360962, 
ENST00000527634, ENST00000540737, 
ENST00000532565, ENST00000525449, 
ENST00000527368, 		ENST00000350997, 
ENST00000536991, ENST00000433932, 
ENST00000460649, ENST00000542506, 
ENST00000541683, 
Fusion gene scores* DoF score13 X 8 X 7=7284 X 8 X 3=96
# samples 165
** MAII scorelog2(16/728*10)=-2.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/96*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C11orf80 [Title/Abstract] AND FADS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC11orf80(66595835)-FADS1(61572233), # samples:1
Anticipated loss of major functional domain due to fusion event.C11orf80-FADS1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFADS1

GO:0007528

neuromuscular junction development

25537362


check buttonFusion gene breakpoints across C11orf80 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FADS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-97-8174-01AC11orf80chr11

66595835

+FADS1chr11

61572233

-


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Fusion Gene ORF analysis for C11orf80-FADS1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000346672ENST00000350997C11orf80chr11

66595835

+FADS1chr11

61572233

-
In-frameENST00000346672ENST00000536991C11orf80chr11

66595835

+FADS1chr11

61572233

-
Frame-shiftENST00000346672ENST00000433932C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000346672ENST00000460649C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000346672ENST00000542506C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000346672ENST00000541683C11orf80chr11

66595835

+FADS1chr11

61572233

-
Frame-shiftENST00000360962ENST00000350997C11orf80chr11

66595835

+FADS1chr11

61572233

-
In-frameENST00000360962ENST00000536991C11orf80chr11

66595835

+FADS1chr11

61572233

-
Frame-shiftENST00000360962ENST00000433932C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000360962ENST00000460649C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000360962ENST00000542506C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000360962ENST00000541683C11orf80chr11

66595835

+FADS1chr11

61572233

-
Frame-shiftENST00000527634ENST00000350997C11orf80chr11

66595835

+FADS1chr11

61572233

-
In-frameENST00000527634ENST00000536991C11orf80chr11

66595835

+FADS1chr11

61572233

-
Frame-shiftENST00000527634ENST00000433932C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000527634ENST00000460649C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000527634ENST00000542506C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000527634ENST00000541683C11orf80chr11

66595835

+FADS1chr11

61572233

-
Frame-shiftENST00000540737ENST00000350997C11orf80chr11

66595835

+FADS1chr11

61572233

-
In-frameENST00000540737ENST00000536991C11orf80chr11

66595835

+FADS1chr11

61572233

-
Frame-shiftENST00000540737ENST00000433932C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000540737ENST00000460649C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000540737ENST00000542506C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000540737ENST00000541683C11orf80chr11

66595835

+FADS1chr11

61572233

-
Frame-shiftENST00000532565ENST00000350997C11orf80chr11

66595835

+FADS1chr11

61572233

-
In-frameENST00000532565ENST00000536991C11orf80chr11

66595835

+FADS1chr11

61572233

-
Frame-shiftENST00000532565ENST00000433932C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000532565ENST00000460649C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000532565ENST00000542506C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000532565ENST00000541683C11orf80chr11

66595835

+FADS1chr11

61572233

-
Frame-shiftENST00000525449ENST00000350997C11orf80chr11

66595835

+FADS1chr11

61572233

-
In-frameENST00000525449ENST00000536991C11orf80chr11

66595835

+FADS1chr11

61572233

-
Frame-shiftENST00000525449ENST00000433932C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000525449ENST00000460649C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000525449ENST00000542506C11orf80chr11

66595835

+FADS1chr11

61572233

-
5CDS-intronENST00000525449ENST00000541683C11orf80chr11

66595835

+FADS1chr11

61572233

-
intron-3CDSENST00000527368ENST00000350997C11orf80chr11

66595835

+FADS1chr11

61572233

-
intron-3CDSENST00000527368ENST00000536991C11orf80chr11

66595835

+FADS1chr11

61572233

-
intron-3CDSENST00000527368ENST00000433932C11orf80chr11

66595835

+FADS1chr11

61572233

-
intron-intronENST00000527368ENST00000460649C11orf80chr11

66595835

+FADS1chr11

61572233

-
intron-intronENST00000527368ENST00000542506C11orf80chr11

66595835

+FADS1chr11

61572233

-
intron-intronENST00000527368ENST00000541683C11orf80chr11

66595835

+FADS1chr11

61572233

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346672C11orf80chr1166595835+ENST00000536991FADS1chr1161572233-2501156771710567
ENST00000360962C11orf80chr1166595835+ENST00000536991FADS1chr1161572233-2609167571818603
ENST00000527634C11orf80chr1166595835+ENST00000536991FADS1chr1161572233-217812442241387387
ENST00000540737C11orf80chr1166595835+ENST00000536991FADS1chr1161572233-22691335811478465
ENST00000532565C11orf80chr1166595835+ENST00000536991FADS1chr1161572233-246015264791669396
ENST00000525449C11orf80chr1166595835+ENST00000536991FADS1chr1161572233-22991365421508488

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346672ENST00000536991C11orf80chr1166595835+FADS1chr1161572233-0.0080618890.99193805
ENST00000360962ENST00000536991C11orf80chr1166595835+FADS1chr1161572233-0.0112834550.9887165
ENST00000527634ENST00000536991C11orf80chr1166595835+FADS1chr1161572233-0.0101081350.9898919
ENST00000540737ENST00000536991C11orf80chr1166595835+FADS1chr1161572233-0.0054543270.9945457
ENST00000532565ENST00000536991C11orf80chr1166595835+FADS1chr1161572233-0.0070179430.99298203
ENST00000525449ENST00000536991C11orf80chr1166595835+FADS1chr1161572233-0.0009592540.99904066

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Fusion Genomic Features for C11orf80-FADS1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C11orf80-FADS1


check button Go to

FGviewer for the breakpoints of chr11:66595835-chr11:61572233

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FADS1

O60427

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: [Isoform 1]: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively (PubMed:10601301, PubMed:10769175). As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells (By similarity). Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6) (By similarity). {ECO:0000250|UniProtKB:Q920L1, ECO:0000250|UniProtKB:Q920R3, ECO:0000269|PubMed:10601301, ECO:0000269|PubMed:10769175}.; FUNCTION: [Isoform 2]: Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity. {ECO:0000250|UniProtKB:A4UVI1}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFADS1chr11:66595835chr11:61572233ENST00000350997512382_386325.3333333333333502.0MotifNote=Histidine box-3
TgeneFADS1chr11:66595835chr11:61572233ENST00000433932512216_220184.33333333333334361.0MotifNote=Histidine box-2
TgeneFADS1chr11:66595835chr11:61572233ENST00000433932512382_386184.33333333333334361.0MotifNote=Histidine box-3
TgeneFADS1chr11:66595835chr11:61572233ENST00000542506512216_220184.33333333333334361.0MotifNote=Histidine box-2
TgeneFADS1chr11:66595835chr11:61572233ENST00000542506512382_386184.33333333333334361.0MotifNote=Histidine box-3
TgeneFADS1chr11:66595835chr11:61572233ENST00000350997512327_444325.3333333333333502.0Topological domainCytoplasmic
TgeneFADS1chr11:66595835chr11:61572233ENST00000433932512289_305184.33333333333334361.0Topological domainLumenal
TgeneFADS1chr11:66595835chr11:61572233ENST00000433932512327_444184.33333333333334361.0Topological domainCytoplasmic
TgeneFADS1chr11:66595835chr11:61572233ENST00000542506512289_305184.33333333333334361.0Topological domainLumenal
TgeneFADS1chr11:66595835chr11:61572233ENST00000542506512327_444184.33333333333334361.0Topological domainCytoplasmic
TgeneFADS1chr11:66595835chr11:61572233ENST00000433932512268_288184.33333333333334361.0TransmembraneHelical
TgeneFADS1chr11:66595835chr11:61572233ENST00000433932512306_326184.33333333333334361.0TransmembraneHelical
TgeneFADS1chr11:66595835chr11:61572233ENST00000542506512268_288184.33333333333334361.0TransmembraneHelical
TgeneFADS1chr11:66595835chr11:61572233ENST00000542506512306_326184.33333333333334361.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFADS1chr11:66595835chr11:61572233ENST0000035099751217_94325.3333333333333502.0DomainCytochrome b5 heme-binding
TgeneFADS1chr11:66595835chr11:61572233ENST0000043393251217_94184.33333333333334361.0DomainCytochrome b5 heme-binding
TgeneFADS1chr11:66595835chr11:61572233ENST0000054250651217_94184.33333333333334361.0DomainCytochrome b5 heme-binding
TgeneFADS1chr11:66595835chr11:61572233ENST00000350997512179_183325.3333333333333502.0MotifNote=Histidine box-1
TgeneFADS1chr11:66595835chr11:61572233ENST00000350997512216_220325.3333333333333502.0MotifNote=Histidine box-2
TgeneFADS1chr11:66595835chr11:61572233ENST00000433932512179_183184.33333333333334361.0MotifNote=Histidine box-1
TgeneFADS1chr11:66595835chr11:61572233ENST00000542506512179_183184.33333333333334361.0MotifNote=Histidine box-1
TgeneFADS1chr11:66595835chr11:61572233ENST00000350997512143_145325.3333333333333502.0Topological domainLumenal
TgeneFADS1chr11:66595835chr11:61572233ENST00000350997512171_267325.3333333333333502.0Topological domainCytoplasmic
TgeneFADS1chr11:66595835chr11:61572233ENST000003509975121_121325.3333333333333502.0Topological domainCytoplasmic
TgeneFADS1chr11:66595835chr11:61572233ENST00000350997512289_305325.3333333333333502.0Topological domainLumenal
TgeneFADS1chr11:66595835chr11:61572233ENST00000433932512143_145184.33333333333334361.0Topological domainLumenal
TgeneFADS1chr11:66595835chr11:61572233ENST00000433932512171_267184.33333333333334361.0Topological domainCytoplasmic
TgeneFADS1chr11:66595835chr11:61572233ENST000004339325121_121184.33333333333334361.0Topological domainCytoplasmic
TgeneFADS1chr11:66595835chr11:61572233ENST00000542506512143_145184.33333333333334361.0Topological domainLumenal
TgeneFADS1chr11:66595835chr11:61572233ENST00000542506512171_267184.33333333333334361.0Topological domainCytoplasmic
TgeneFADS1chr11:66595835chr11:61572233ENST000005425065121_121184.33333333333334361.0Topological domainCytoplasmic
TgeneFADS1chr11:66595835chr11:61572233ENST00000350997512122_142325.3333333333333502.0TransmembraneHelical
TgeneFADS1chr11:66595835chr11:61572233ENST00000350997512146_170325.3333333333333502.0TransmembraneHelical
TgeneFADS1chr11:66595835chr11:61572233ENST00000350997512268_288325.3333333333333502.0TransmembraneHelical
TgeneFADS1chr11:66595835chr11:61572233ENST00000350997512306_326325.3333333333333502.0TransmembraneHelical
TgeneFADS1chr11:66595835chr11:61572233ENST00000433932512122_142184.33333333333334361.0TransmembraneHelical
TgeneFADS1chr11:66595835chr11:61572233ENST00000433932512146_170184.33333333333334361.0TransmembraneHelical
TgeneFADS1chr11:66595835chr11:61572233ENST00000542506512122_142184.33333333333334361.0TransmembraneHelical
TgeneFADS1chr11:66595835chr11:61572233ENST00000542506512146_170184.33333333333334361.0TransmembraneHelical


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Fusion Gene Sequence for C11orf80-FADS1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000346672_ENST00000536991_TCGA-97-8174-01A_C11orf80_chr11_66595835_+_FADS1_chr11_61572233_length(transcript)=2501nt_BP=1567nt
GGAAGGGATGGGCTCGCGCTGCCGGGCGTGGGCGTGGACTCGGGCGTGGGCACTGGCGGAGTTCCAAGCCCGGGCTGAGGAGGGGGCGGC
GGCGGCGGCGGCGGCGGCGGGCGGGTACCCTTCGACTGGGCGTTGCCGCTGTTCCCTGCGCGGCATGGAGGGGACGGCCGTGGCCGTGTT
CGAGATTTTGAGATTTTTAATAATTCACTGGAAGTGTGACATAGATGTATCAAAGGGAGCATTGCTAGAAGGGCAGCTAGTGATTTCCAT
AGAAGGATTAAATTCTAAGCACCAGGCAAATGCTCTTCATTGTGTAACAACTAGATGGAGTCTCACTCTGTTACCCAGGCCGGAGTGCAG
TGGCGCAGTCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCATGCCTCAGTCCCCCGAGTAGCTGGGATTACAGATGC
CCACCACCATGCCTGGCTAATTATGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTCCTAAAAGAAATACAGTC
CATACTGCCCGGAATCTCTGCAAAGCTGACTTGGACTTCAGAGGAAGGCAGCTATTCTCAGGATATGACAGGGGTAACACCCTTCCAGAT
GATTTTTGAGGTTGATGAAAAGCCCAGAACCTTGATGACAGATTGTCTGGTTATAAAGCATTTTTTACGTAAAATCATCATGGTGCACCC
TAAGGTCAGATTTCATTTCAGTGTAAAGGTAAATGGAATCCTCTCCACAGAGATCTTTGGGGTGGAGAATGAACCCACTTTGAACCTTGG
GAATGGAATTGCTCTTTTGGTCGACTCCCAGCATTATGTGAGTAGACCAAATTTTGGTACAATTGAATCACACTGCAGCAGAATTCACCC
TGTGCTAGGACATCCAGTAATGCTTTTCATCCCTGAAGACGTGGCTGGCATGGACTTGTTGGGAGAACTGATACTGACTCCAGCAGCTGC
ACTGTGCCCCAGCCCAAAGGTTTCTTCCAACCAGCTTAACAGGATTTCTTCAGTTTCCATATTTCTATATGGACCTTTGGGTCTGCCTCT
GATATTGTCAACTTGGGAGCAGCCGATGACTACTTTCTTCAAAGATACCTCTTCTTTAGTTGACTGGAAAAAATACCATTTGTGTATGAT
ACCCAATTTGGATCTCAATTTGGATAGAGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGGAGGATCAGTCTCAGAC
TATGGATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAATGGAAATCTGGGGAGT
CTATACTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAATTCACTGTGGACAAGGT
CTTGGAGCAACATCACCAGGCTGCCAAGGCAGCTGACACACAAGAGTTCAGGACCAAACTGCACAAAGTATTTCGTGAGATCACCCAACA
CCAATTTCTTCACCACTGCTCATGTGAGGTGAAGCAGCTCACTAAAGGAGTCAGGGCAGCTCTGGCTAGATGCCTATCTTCACCAATAAC
AACAGCCACCCTGCCCAGTCTGGAAGAAGAGGAGGAAGACTCTGGAGCCAAGGCAGAGGGGAGCTTGAGGGACAATGCCACTATAGTTTA
ATACTCAGAGGGGGTTGGGTTTGGGGACATAAAGCCTCTGACTCAAACTCCTCCCTTTTATCTTCTAGCCACAGTTCTAAGACCCAAAGT
GGGGGGTGGACACAGAAGTCCCTAGGAGGGAAGGAGCTGTTGGGGCAGGGGTGTAAATTATTTCCTTTTTCTAGTTTGGCACATGCAGGT
AGTTGGTGAACAGAGAGAACCAGGAGGGTAACAGAAGAGGAGGGACCTACTGAACCCAGAGTCAGGAAGAGATTTAACACTAAAATTCCA
CTCATGCCGGGCGTGGTGGCACGCGCCTGTAATCCCAGCTACCTCTTTTTCCCACGATGCCTCGACACAATTACCACAAAGTGGCTCCCC
TGGTGCAGTCCTTGTGTGCCAAGCATGGCATAGAGTACCAGTCCAAGCCCCTGCTGTCAGCCTTCGCCGACATCATCCACTCCAGGCCAC
ATGCAATGTCCACAAGTCTGCCTTCAATGACTGGTTCAGTGGACACCTCAACTTCCAGATTGAGCACCAGTTCCTGGAAAGCAACTGGTT
TGTGTGGGTGACACAGATGAACCATATTCCCATGCACATTGATCATGACCGGAACATGGACTGGGTTTCCACCCAGGACTTGGCCTGGAT
GATTACCTTCTACGTCCGCTTCTTCCTCACTTATGTGCCACTATTGGGGCTGAAAGCCTTCCTGGGCCTTTTCTTCATAGTCAGTTGGGC

>In-frame_ENST00000346672_ENST00000536991_TCGA-97-8174-01A_C11orf80_chr11_66595835_+_FADS1_chr11_61572233_length(amino acids)=567AA_start in transcript=7_stop in transcript=1710
MGSRCRAWAWTRAWALAEFQARAEEGAAAAAAAAGGYPSTGRCRCSLRGMEGTAVAVFEILRFLIIHWKCDIDVSKGALLEGQLVISIEG
LNSKHQANALHCVTTRWSLTLLPRPECSGAVSAHCNLHLPGSSDSHASVPRVAGITDAHHHAWLIMVASAGSLFGGMVLKKFLKEIQSIL
PGISAKLTWTSEEGSYSQDMTGVTPFQMIFEVDEKPRTLMTDCLVIKHFLRKIIMVHPKVRFHFSVKVNGILSTEIFGVENEPTLNLGNG
IALLVDSQHYVSRPNFGTIESHCSRIHPVLGHPVMLFIPEDVAGMDLLGELILTPAAALCPSPKVSSNQLNRISSVSIFLYGPLGLPLIL
STWEQPMTTFFKDTSSLVDWKKYHLCMIPNLDLNLDRDLVLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYT
LLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAADTQEFRTKLHKVFREITQHQFLHHCSCEVKQLTKGVRAALARCLSSPITTA

--------------------------------------------------------------
>In-frame_ENST00000360962_ENST00000536991_TCGA-97-8174-01A_C11orf80_chr11_66595835_+_FADS1_chr11_61572233_length(transcript)=2609nt_BP=1675nt
GGAAGGGATGGGCTCGCGCTGCCGGGCGTGGGCGTGGACTCGGGCGTGGGCACTGGCGGAGTTCCAAGCCCGGGCTGAGGAGGGGGCGGC
GGCGGCGGCGGCGGCGGCGGGCGGGTACCCTTCGACTGGGCGTTGCCGCTGTTCCCTGCGCGGCATGGAGGGGACGGCCGTGGCCGTGTT
CGAGATTTTGAGATTTTTAATAATTCACTGGAAGTGTGACATAGATGTATCAAAGGGAGCATTGCTAGAAGGGCAGCTAGTGATTTCCAT
AGAAGGATTAAATTCTAAGCACCAGGCAAATGCTCTTCATTGTGTAACAACTAGATGGAGTCTCACTCTGTTACCCAGGCCGGAGTGCAG
TGGCGCAGTCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCATGCCTCAGTCCCCCGAGTAGCTGGGATTACAGATGC
CCACCACCATGCCTGGCTAATTATGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTCCTAAAAGAAATACAGTC
CATACTGCCCGGAATCTCTGCAAAGCTGACTTGGACTTCAGAGGAAGGCAGCTATTCTCAGGATATGACAGGGGTAACACCCTTCCAGAT
GATTTTTGAGGTTGATGAAAAGCCCAGAACCTTGATGACAGATTGTCTGGTTATAAAGCATTTTTTACGTAAAATCATCATGGTGCACCC
TAAGGTCAGATTTCATTTCAGTGTAAAGGTAAATGGAATCCTCTCCACAGAGATCTTTGGGGTGGAGAATGAACCCACTTTGAACCTTGG
GAATGGAATTGCTCTTTTGGTCGACTCCCAGCATTATGTGAGACCAAATTTTGGTACAATTGAATCACACTGCAGCAGAATTCACCCTGT
GCTAGGACATCCAGTAATGCTTTTCATCCCTGAAGACGTGGCTGGCATGGACTTGTTGGGAGAACTGATACTGACTCCAGCAGCTGCACT
GTGCCCCAGCCCAAAGGTTTCTTCCAACCAGCTTAACAGGATTTCTTCAGTTTCCATATTTCTATATGGACCTTTGGGTCTGCCTCTGAT
ATTGTCAACTTGGGAGCAGCCGATGACTACTTTCTTCAAAGATACCTCTTCTTTAGTTGACTGGAAAAAATACCATTTGTGTATGATACC
CAATTTGGATCTCAATTTGGATAGAGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGGAGGATCAGTCTCAGACTAT
GGATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAATGGAAATCTGGGGAGTCTA
TACTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAATTCACTGTGGACAAGGTCTT
GGAGCAACATCACCAGGCTGCCAAGGCTCAGCAGAAACTACAGGCCTCACTCTCAGTGGCTGTGAACTCCATCATGAGTATTCTGACTGG
AAGCACTAGGAGCAGCTTCCGAAAGATGTGTCTCCAGACCCTTCAAGCAGCTGACACACAAGAGTTCAGGACCAAACTGCACAAAGTATT
TCGTGAGATCACCCAACACCAATTTCTTCACCACTGCTCATGTGAGGTGAAGCAGCTCACTAAAGGAGTCAGGGCAGCTCTGGCTAGATG
CCTATCTTCACCAATAACAACAGCCACCCTGCCCAGTCTGGAAGAAGAGGAGGAAGACTCTGGAGCCAAGGCAGAGGGGAGCTTGAGGGA
CAATGCCACTATAGTTTAATACTCAGAGGGGGTTGGGTTTGGGGACATAAAGCCTCTGACTCAAACTCCTCCCTTTTATCTTCTAGCCAC
AGTTCTAAGACCCAAAGTGGGGGGTGGACACAGAAGTCCCTAGGAGGGAAGGAGCTGTTGGGGCAGGGGTGTAAATTATTTCCTTTTTCT
AGTTTGGCACATGCAGGTAGTTGGTGAACAGAGAGAACCAGGAGGGTAACAGAAGAGGAGGGACCTACTGAACCCAGAGTCAGGAAGAGA
TTTAACACTAAAATTCCACTCATGCCGGGCGTGGTGGCACGCGCCTGTAATCCCAGCTACCTCTTTTTCCCACGATGCCTCGACACAATT
ACCACAAAGTGGCTCCCCTGGTGCAGTCCTTGTGTGCCAAGCATGGCATAGAGTACCAGTCCAAGCCCCTGCTGTCAGCCTTCGCCGACA
TCATCCACTCCAGGCCACATGCAATGTCCACAAGTCTGCCTTCAATGACTGGTTCAGTGGACACCTCAACTTCCAGATTGAGCACCAGTT
CCTGGAAAGCAACTGGTTTGTGTGGGTGACACAGATGAACCATATTCCCATGCACATTGATCATGACCGGAACATGGACTGGGTTTCCAC
CCAGGACTTGGCCTGGATGATTACCTTCTACGTCCGCTTCTTCCTCACTTATGTGCCACTATTGGGGCTGAAAGCCTTCCTGGGCCTTTT

>In-frame_ENST00000360962_ENST00000536991_TCGA-97-8174-01A_C11orf80_chr11_66595835_+_FADS1_chr11_61572233_length(amino acids)=603AA_start in transcript=7_stop in transcript=1818
MGSRCRAWAWTRAWALAEFQARAEEGAAAAAAAAGGYPSTGRCRCSLRGMEGTAVAVFEILRFLIIHWKCDIDVSKGALLEGQLVISIEG
LNSKHQANALHCVTTRWSLTLLPRPECSGAVSAHCNLHLPGSSDSHASVPRVAGITDAHHHAWLIMVASAGSLFGGMVLKKFLKEIQSIL
PGISAKLTWTSEEGSYSQDMTGVTPFQMIFEVDEKPRTLMTDCLVIKHFLRKIIMVHPKVRFHFSVKVNGILSTEIFGVENEPTLNLGNG
IALLVDSQHYVRPNFGTIESHCSRIHPVLGHPVMLFIPEDVAGMDLLGELILTPAAALCPSPKVSSNQLNRISSVSIFLYGPLGLPLILS
TWEQPMTTFFKDTSSLVDWKKYHLCMIPNLDLNLDRDLVLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTL
LTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAQQKLQASLSVAVNSIMSILTGSTRSSFRKMCLQTLQAADTQEFRTKLHKVFRE

--------------------------------------------------------------
>In-frame_ENST00000527634_ENST00000536991_TCGA-97-8174-01A_C11orf80_chr11_66595835_+_FADS1_chr11_61572233_length(transcript)=2178nt_BP=1244nt
GGACTCGGGCGTGGGCACTGGCGGAGTTCCAAGCCCGGGCTGAGGAGGGGGCGGCGGCGGCGGCGGCGGCGGCGGGCGGGTACCCTTCGA
CTGGGCGTTGCCGCTGTTCCCTGCGCGGCATGGAGGGGACGGCCGTGGCCGTGTTCGAGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCAT
GGTCCTCAAGAAGTTCCTAAAAGGTTGATGAAAAGCCCAGAACCTTGATGACAGATTGTCTGGTTATAAAGCATTTTTTACGTAAAATCA
TCATGGTGCACCCTAAGGTCAGATTTCATTTCAGTGTAAAGGTAAATGGAATCCTCTCCACAGAGATCTTTGGGGTGGAGAATGAACCCA
CTTTGAACCTTGGGAATGGAATTGCTCTTTTGGTCGACTCCCAGCATTATGTGAGTAGACCAAATTTTGGTACAATTGAATCACACTGCA
GCAGAATTCACCCTGTGCTAGGACATCCAGTAATGCTTTTCATCCCTGAAGACGTGGCTGGCATGGACTTGTTGGGAGAACTGATACTGA
CTCCAGCAGCTGCACTGTGCCCCAGCCCAAAGGTTTCTTCCAACCAGCTTAACAGGATTTCTTCACAACTACACATATTTCTATATGGAC
CTTTGGGTCTGCCTCTGATATTGTCAACTTGGGAGCAGCCGATGACTACTTTCTTCAAAGATACCTCTTCTTTAGTTGACTGGAAAAAAT
ACCATTTGTGTATGATACCCAATTTGGATCTCAATTTGGATAGAGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGG
AGGATCAGTCTCAGACTATGGATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAA
TGGAAATCTGGGGAGTCTATACTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAAT
TCACTGTGGACAAGGTCTTGGAGCAACATCACCAGGCTGCCAAGGCTCAGCAGAAACTACAGGCCTCACTCTCAGTGGCTGTGAACTCCA
TCATGAGTATTCTGACTGGAAGCACTAGGAGCAGCTTCCGAAAGATGTGTCTCCAGACCCTTCAAGCAGCTGACACACAAGAGTTCAGGA
CCAAACTGCACAAAGTATTTCGTGAGATCACCCAACACCAATTTCTTCACCACTGCTCATGTGAGGTGAAGCAGCTCACTAAAGGAGTCA
GGGCAGCTCTGGCTAGATGCCTATCTTCACCAATAACAACAGCCACCCTGCCCAGTCTGGAAGAAGAGGAGGAAGACTCTGGAGCCAAGG
CAGAGGGGAGCTTGAGGGACAATGCCACTATAGTTTAATACTCAGAGGGGGTTGGGTTTGGGGACATAAAGCCTCTGACTCAAACTCCTC
CCTTTTATCTTCTAGCCACAGTTCTAAGACCCAAAGTGGGGGGTGGACACAGAAGTCCCTAGGAGGGAAGGAGCTGTTGGGGCAGGGGTG
TAAATTATTTCCTTTTTCTAGTTTGGCACATGCAGGTAGTTGGTGAACAGAGAGAACCAGGAGGGTAACAGAAGAGGAGGGACCTACTGA
ACCCAGAGTCAGGAAGAGATTTAACACTAAAATTCCACTCATGCCGGGCGTGGTGGCACGCGCCTGTAATCCCAGCTACCTCTTTTTCCC
ACGATGCCTCGACACAATTACCACAAAGTGGCTCCCCTGGTGCAGTCCTTGTGTGCCAAGCATGGCATAGAGTACCAGTCCAAGCCCCTG
CTGTCAGCCTTCGCCGACATCATCCACTCCAGGCCACATGCAATGTCCACAAGTCTGCCTTCAATGACTGGTTCAGTGGACACCTCAACT
TCCAGATTGAGCACCAGTTCCTGGAAAGCAACTGGTTTGTGTGGGTGACACAGATGAACCATATTCCCATGCACATTGATCATGACCGGA
ACATGGACTGGGTTTCCACCCAGGACTTGGCCTGGATGATTACCTTCTACGTCCGCTTCTTCCTCACTTATGTGCCACTATTGGGGCTGA
AAGCCTTCCTGGGCCTTTTCTTCATAGTCAGTTGGGCCCCCAGCCTTGCTGCCTCTCTACTTCCAGTGGTATATTTTCTATTTTGTTATC

>In-frame_ENST00000527634_ENST00000536991_TCGA-97-8174-01A_C11orf80_chr11_66595835_+_FADS1_chr11_61572233_length(amino acids)=387AA_start in transcript=224_stop in transcript=1387
MMTDCLVIKHFLRKIIMVHPKVRFHFSVKVNGILSTEIFGVENEPTLNLGNGIALLVDSQHYVSRPNFGTIESHCSRIHPVLGHPVMLFI
PEDVAGMDLLGELILTPAAALCPSPKVSSNQLNRISSQLHIFLYGPLGLPLILSTWEQPMTTFFKDTSSLVDWKKYHLCMIPNLDLNLDR
DLVLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAK
AQQKLQASLSVAVNSIMSILTGSTRSSFRKMCLQTLQAADTQEFRTKLHKVFREITQHQFLHHCSCEVKQLTKGVRAALARCLSSPITTA

--------------------------------------------------------------
>In-frame_ENST00000540737_ENST00000536991_TCGA-97-8174-01A_C11orf80_chr11_66595835_+_FADS1_chr11_61572233_length(transcript)=2269nt_BP=1335nt
ACTGGCGGAGTTCCAAGCCCGGGCTGAGGAGGGGGCGGCGGCGGCGGCGGCGGCGGCGGGCGGGTACCCTTCGACTGGGCGTTGCCGCTG
TTCCCTGCGCGGCATGGAGGGGACGGCCGTGGCCGTGTTCGAGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTC
CTAAAAGAAATACAGTCCATACTGCCCGGAATCTCTGCAAAGCTGACTTGGACTTCAGAGGAAGGCAGCTATTCTCAGGATATGACAGGG
GTAACACCCTTCCAGATGATTTTTGAGGTTGATGAAAAGCCCAGAACCTTGATGACAGATTGTCTGGTTATAAAGCATTTTTTACGTAAA
ATCATCATGGTGCACCCTAAGGTCAGATTTCATTTCAGTGTAAAGGTAAATGGAATCCTCTCCACAGAGATCTTTGGGGTGGAGAATGAA
CCCACTTTGAACCTTGGGAATGGAATTGCTCTTTTGGTCGACTCCCAGCATTATGTGAGTAGACCAAATTTTGGTACAATTGAATCACAC
TGCAGCAGAATTCACCCTGTGCTAGGACATCCAGTAATGCTTTTCATCCCTGAAGACGTGGCTGGCATGGACTTGTTGGGAGAACTGATA
CTGACTCCAGCAGCTGCACTGTGCCCCAGCCCAAAGGTTTCTTCCAACCAGCTTAACAGGATTTCTTCAGTTTCCATATTTCTATATGGA
CCTTTGGGTCTGCCTCTGATATTGTCAACTTGGGAGCAGCCGATGACTACTTTCTTCAAAGATACCTCTTCTTTAGTTGACTGGAAAAAA
TACCATTTGTGTATGATACCCAATTTGGATCTCAATTTGGATAGAGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAG
GAGGATCAGTCTCAGACTATGGATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAA
ATGGAAATCTGGGGAGTCTATACTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAA
TTCACTGTGGACAAGGTCTTGGAGCAACATCACCAGGCTGCCAAGGCTCAGCAGAAACTACAGGCCTCACTCTCAGTGGCTGTGAACTCC
ATCATGAGTATTCTGACTGGAAGCACTAGGAGCAGCTTCCGAAAGATGTGTCTCCAGACCCTTCAAGCAGCTGACACACAAGAGTTCAGG
ACCAAACTGCACAAAGTATTTCGTGAGATCACCCAACACCAATTTCTTCACCACTGCTCATGTGAGGTGAAGCAGCTCACTAAAGGAGTC
AGGGCAGCTCTGGCTAGATGCCTATCTTCACCAATAACAACAGCCACCCTGCCCAGTCTGGAAGAAGAGGAGGAAGACTCTGGAGCCAAG
GCAGAGGGGAGCTTGAGGGACAATGCCACTATAGTTTAATACTCAGAGGGGGTTGGGTTTGGGGACATAAAGCCTCTGACTCAAACTCCT
CCCTTTTATCTTCTAGCCACAGTTCTAAGACCCAAAGTGGGGGGTGGACACAGAAGTCCCTAGGAGGGAAGGAGCTGTTGGGGCAGGGGT
GTAAATTATTTCCTTTTTCTAGTTTGGCACATGCAGGTAGTTGGTGAACAGAGAGAACCAGGAGGGTAACAGAAGAGGAGGGACCTACTG
AACCCAGAGTCAGGAAGAGATTTAACACTAAAATTCCACTCATGCCGGGCGTGGTGGCACGCGCCTGTAATCCCAGCTACCTCTTTTTCC
CACGATGCCTCGACACAATTACCACAAAGTGGCTCCCCTGGTGCAGTCCTTGTGTGCCAAGCATGGCATAGAGTACCAGTCCAAGCCCCT
GCTGTCAGCCTTCGCCGACATCATCCACTCCAGGCCACATGCAATGTCCACAAGTCTGCCTTCAATGACTGGTTCAGTGGACACCTCAAC
TTCCAGATTGAGCACCAGTTCCTGGAAAGCAACTGGTTTGTGTGGGTGACACAGATGAACCATATTCCCATGCACATTGATCATGACCGG
AACATGGACTGGGTTTCCACCCAGGACTTGGCCTGGATGATTACCTTCTACGTCCGCTTCTTCCTCACTTATGTGCCACTATTGGGGCTG
AAAGCCTTCCTGGGCCTTTTCTTCATAGTCAGTTGGGCCCCCAGCCTTGCTGCCTCTCTACTTCCAGTGGTATATTTTCTATTTTGTTAT

>In-frame_ENST00000540737_ENST00000536991_TCGA-97-8174-01A_C11orf80_chr11_66595835_+_FADS1_chr11_61572233_length(amino acids)=465AA_start in transcript=81_stop in transcript=1478
MPLFPARHGGDGRGRVRVASAGSLFGGMVLKKFLKEIQSILPGISAKLTWTSEEGSYSQDMTGVTPFQMIFEVDEKPRTLMTDCLVIKHF
LRKIIMVHPKVRFHFSVKVNGILSTEIFGVENEPTLNLGNGIALLVDSQHYVSRPNFGTIESHCSRIHPVLGHPVMLFIPEDVAGMDLLG
ELILTPAAALCPSPKVSSNQLNRISSVSIFLYGPLGLPLILSTWEQPMTTFFKDTSSLVDWKKYHLCMIPNLDLNLDRDLVLPDVSYQVE
SSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAQQKLQASLSVA
VNSIMSILTGSTRSSFRKMCLQTLQAADTQEFRTKLHKVFREITQHQFLHHCSCEVKQLTKGVRAALARCLSSPITTATLPSLEEEEEDS

--------------------------------------------------------------
>In-frame_ENST00000532565_ENST00000536991_TCGA-97-8174-01A_C11orf80_chr11_66595835_+_FADS1_chr11_61572233_length(transcript)=2460nt_BP=1526nt
GGAGGGGACGGCCGTGGCCGTGTTCGAGATTTTGAGATTTTTAATAATTCACTGGAAGTGTGACATAGATGTATCAAAGGGAGCATTGCT
AGAAGGGCAGCTAGTGATTTCCATAGAAGGATTAAATTCTAAGCACCAGGCAAATGCTCTTCATTGTGTAACAACTAGATGGAGTCTCAC
TCTGTTACCCAGGCCGGAGTGCAGTGGCGCAGTCTCGGCTCACTGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCATGCCTCAGTCCC
CCGAGTAGCTGGGATTACAGATGCCCACCACCATGCCTGGCTAATTATGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAA
GAAGTTCCTAAAAGAAATACAGTCCATACTGCCCGGAATCTCTGCAAAGCTGACTTGGACTTCAGAGGAAGGCAGCTATTCTCAGGATAT
GACAGGGGTAACACCCTTCCAGATGATTTTTGAGGCAGGTTGATGAAAAGCCCAGAACCTTGATGACAGATTGTCTGGTTATAAAGCATT
TTTTACGTAAAATCATCATGGTGCACCCTAAGGTCAGATTTCATTTCAGTGTAAAGGTAAATGGAATCCTCTCCACAGAGATCTTTGGGG
TGGAGAATGAACCCACTTTGAACCTTGGGAATGGAATTGCTCTTTTGGTCGACTCCCAGCATTATGTGAGACCAAATTTTGGTACAATTG
AATCACACTGCAGCAGAATTCACCCTGTGCTAGGACATCCAGTAATGCTTTTCATCCCTGAAGACGTGGCTGGCATGGACTTGTTGGGAG
AACTGATACTGACTCCAGCAGCTGCACTGTGCCCCAGCCCAAAGGTTTCTTCCAACCAGCTTAACAGGATTTCTTCACAACTACACATAT
TTCTATATGGACCTTTGGGTCTGCCTCTGATATTGTCAACTTGGGAGCAGCCGATGACTACTTTCTTCAAAGATACCTCTTCTTTAGTTG
ACTGGAAAAAATACCATTTGTGTATGATACCCAATTTGGATCTCAATTTGGATAGAGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGG
AATCCAGTGAGGAGGATCAGTCTCAGACTATGGATCCTCAAGGACAAACTCTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTC
CAGTCCAGCAAATGGAAATCTGGGGAGTCTATACTTTGCTCACAACTCATCTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAG
GTTCCATCCAATTCACTGTGGACAAGGTCTTGGAGCAACATCACCAGGCTGCCAAGGCTCAGCAGAAACTACAGGCCTCACTCTCAGTGG
CTGTGAACTCCATCATGAGTATTCTGACTGGAAGCACTAGGAGCAGCTTCCGAAAGATGTGTCTCCAGACCCTTCAAGCAGCTGACACAC
AAGAGTTCAGGACCAAACTGCACAAAGTATTTCGTGAGATCACCCAACACCAATTTCTTCACCACTGCTCATGTGAGGTGAAGCAGCTCA
CTAAAGGAGTCAGGGCAGCTCTGGCTAGATGCCTATCTTCACCAATAACAACAGCCACCCTGCCCAGTCTGGAAGAAGAGGAGGAAGACT
CTGGAGCCAAGGCAGAGGGGAGCTTGAGGGACAATGCCACTATAGTTTAATACTCAGAGGGGGTTGGGTTTGGGGACATAAAGCCTCTGA
CTCAAACTCCTCCCTTTTATCTTCTAGCCACAGTTCTAAGACCCAAAGTGGGGGGTGGACACAGAAGTCCCTAGGAGGGAAGGAGCTGTT
GGGGCAGGGGTGTAAATTATTTCCTTTTTCTAGTTTGGCACATGCAGGTAGTTGGTGAACAGAGAGAACCAGGAGGGTAACAGAAGAGGA
GGGACCTACTGAACCCAGAGTCAGGAAGAGATTTAACACTAAAATTCCACTCATGCCGGGCGTGGTGGCACGCGCCTGTAATCCCAGCTA
CCTCTTTTTCCCACGATGCCTCGACACAATTACCACAAAGTGGCTCCCCTGGTGCAGTCCTTGTGTGCCAAGCATGGCATAGAGTACCAG
TCCAAGCCCCTGCTGTCAGCCTTCGCCGACATCATCCACTCCAGGCCACATGCAATGTCCACAAGTCTGCCTTCAATGACTGGTTCAGTG
GACACCTCAACTTCCAGATTGAGCACCAGTTCCTGGAAAGCAACTGGTTTGTGTGGGTGACACAGATGAACCATATTCCCATGCACATTG
ATCATGACCGGAACATGGACTGGGTTTCCACCCAGGACTTGGCCTGGATGATTACCTTCTACGTCCGCTTCTTCCTCACTTATGTGCCAC
TATTGGGGCTGAAAGCCTTCCTGGGCCTTTTCTTCATAGTCAGTTGGGCCCCCAGCCTTGCTGCCTCTCTACTTCCAGTGGTATATTTTC

>In-frame_ENST00000532565_ENST00000536991_TCGA-97-8174-01A_C11orf80_chr11_66595835_+_FADS1_chr11_61572233_length(amino acids)=396AA_start in transcript=479_stop in transcript=1669
MRQVDEKPRTLMTDCLVIKHFLRKIIMVHPKVRFHFSVKVNGILSTEIFGVENEPTLNLGNGIALLVDSQHYVRPNFGTIESHCSRIHPV
LGHPVMLFIPEDVAGMDLLGELILTPAAALCPSPKVSSNQLNRISSQLHIFLYGPLGLPLILSTWEQPMTTFFKDTSSLVDWKKYHLCMI
PNLDLNLDRDLVLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKV
LEQHHQAAKAQQKLQASLSVAVNSIMSILTGSTRSSFRKMCLQTLQAADTQEFRTKLHKVFREITQHQFLHHCSCEVKQLTKGVRAALAR

--------------------------------------------------------------
>In-frame_ENST00000525449_ENST00000536991_TCGA-97-8174-01A_C11orf80_chr11_66595835_+_FADS1_chr11_61572233_length(transcript)=2299nt_BP=1365nt
ATAATTCACTGGAAGTGTGACATAGATGTATCAAAGGGAGCATTGCTAGAAGGGCAGCTAGTGATTTCCATAGAAGGATTAAATTCTAAG
CACCAGGCAAATGCTCTTCATTGTGTAACAACTAGATGGAGTCTCACTCTGTTACCCAGGCCGGAGTGCAGTGGCGCAGTCTCGGCTCAC
TGCAACCTCCACCTCCCAGGTTCAAGTGATTCTCATGCCTCAGTCCCCCGAGTAGCTGGGATTACAGATGCCCACCACCATGCCTGGCTA
ATTATGGTTGCTTCTGCAGGAAGCCTTTTTGGTGGCATGGTCCTCAAGAAGTTCCTAAAAGAAATACAGTCCATACTGCCCGGAATCTCT
GCAAAGCTGACTTGGACTTCAGAGGAAGGCAGCTATTCTCAGGATATGACAGGGGTAACACCCTTCCAGATGATTTTTGAGGTTGATGAA
AAGCCCAGAACCTTGATGACAGATTGTCTGGTTATAAAGCATTTTTTACGTAAAATCATCATGGTGCACCCTAAGGTCAGATTTCATTTC
AGTGTAAAGGTAAATGGAATCCTCTCCACAGAGATCTTTGGGGTGGAGAATGAACCCACTTTGAACCTTGGGAATGGAATTGCTCTTTTG
GTCGACTCCCAGCATTATGTGAGACCAAATTTTGGTACAATTGAATCACACTGCAGCAGAATTCACCCTGTGCTAGGACATCCAGTAATG
CTTTTCATCCCTGAAGACGTGGCTGGCATGGACTTGTTGGGAGAACTGATACTGACTCCAGCAGCTGCACTGTGCCCCAGCCCAAAGGTT
TCTTCCAACCAGCTTAACAGGATTTCTTCAGTTTCCATATTTCTATATGGACCTTTGGGTCTGCCTCTGATATTGTCAACTTGGGAGCAG
CCGATGACTACTTTCTTCAAAGATACCTCTTCTTTAGTTGACTGGAAAAAATACCATTTGTGTATGATACCCAATTTGGATCTCAATTTG
GATAGAGATTTGGTGCTTCCAGATGTGAGTTATCAGGTGGAATCCAGTGAGGAGGATCAGTCTCAGACTATGGATCCTCAAGGACAAACT
CTGCTGCTTTTTCTCTTTGTGGATTTCCACAGTGCATTTCCAGTCCAGCAAATGGAAATCTGGGGAGTCTATACTTTGCTCACAACTCAT
CTCAATGCCATCCTTGTGGAGAGCCACAGTGTAGTGCAAGGTTCCATCCAATTCACTGTGGACAAGGTCTTGGAGCAACATCACCAGGCT
GCCAAGGCAGCTGACACACAAGAGTTCAGGACCAAACTGCACAAAGTATTTCGTGAGATCACCCAACACCAATTTCTTCACCACTGCTCA
TGTGAGGTGAAGCAGCTCACTAAAGGAGTCAGGGCAGCTCTGGCTAGATGCCTATCTTCACCAATAACAACAGCCACCCTGCCCAGTCTG
GAAGAAGAGGAGGAAGACTCTGGAGCCAAGGCAGAGGGGAGCTTGAGGGACAATGCCACTATAGTTTAATACTCAGAGGGGGTTGGGTTT
GGGGACATAAAGCCTCTGACTCAAACTCCTCCCTTTTATCTTCTAGCCACAGTTCTAAGACCCAAAGTGGGGGGTGGACACAGAAGTCCC
TAGGAGGGAAGGAGCTGTTGGGGCAGGGGTGTAAATTATTTCCTTTTTCTAGTTTGGCACATGCAGGTAGTTGGTGAACAGAGAGAACCA
GGAGGGTAACAGAAGAGGAGGGACCTACTGAACCCAGAGTCAGGAAGAGATTTAACACTAAAATTCCACTCATGCCGGGCGTGGTGGCAC
GCGCCTGTAATCCCAGCTACCTCTTTTTCCCACGATGCCTCGACACAATTACCACAAAGTGGCTCCCCTGGTGCAGTCCTTGTGTGCCAA
GCATGGCATAGAGTACCAGTCCAAGCCCCTGCTGTCAGCCTTCGCCGACATCATCCACTCCAGGCCACATGCAATGTCCACAAGTCTGCC
TTCAATGACTGGTTCAGTGGACACCTCAACTTCCAGATTGAGCACCAGTTCCTGGAAAGCAACTGGTTTGTGTGGGTGACACAGATGAAC
CATATTCCCATGCACATTGATCATGACCGGAACATGGACTGGGTTTCCACCCAGGACTTGGCCTGGATGATTACCTTCTACGTCCGCTTC
TTCCTCACTTATGTGCCACTATTGGGGCTGAAAGCCTTCCTGGGCCTTTTCTTCATAGTCAGTTGGGCCCCCAGCCTTGCTGCCTCTCTA

>In-frame_ENST00000525449_ENST00000536991_TCGA-97-8174-01A_C11orf80_chr11_66595835_+_FADS1_chr11_61572233_length(amino acids)=488AA_start in transcript=42_stop in transcript=1508
MLEGQLVISIEGLNSKHQANALHCVTTRWSLTLLPRPECSGAVSAHCNLHLPGSSDSHASVPRVAGITDAHHHAWLIMVASAGSLFGGMV
LKKFLKEIQSILPGISAKLTWTSEEGSYSQDMTGVTPFQMIFEVDEKPRTLMTDCLVIKHFLRKIIMVHPKVRFHFSVKVNGILSTEIFG
VENEPTLNLGNGIALLVDSQHYVRPNFGTIESHCSRIHPVLGHPVMLFIPEDVAGMDLLGELILTPAAALCPSPKVSSNQLNRISSVSIF
LYGPLGLPLILSTWEQPMTTFFKDTSSLVDWKKYHLCMIPNLDLNLDRDLVLPDVSYQVESSEEDQSQTMDPQGQTLLLFLFVDFHSAFP
VQQMEIWGVYTLLTTHLNAILVESHSVVQGSIQFTVDKVLEQHHQAAKAADTQEFRTKLHKVFREITQHQFLHHCSCEVKQLTKGVRAAL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C11orf80-FADS1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C11orf80-FADS1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneFADS1O60427DB00132alpha-Linolenic acidLigandSmall moleculeApproved|Investigational|Nutraceutical
TgeneFADS1O60427DB00132alpha-Linolenic acidLigandSmall moleculeApproved|Investigational|Nutraceutical
TgeneFADS1O60427DB00159IcosapentAgonistSmall moleculeApproved|Nutraceutical
TgeneFADS1O60427DB00159IcosapentAgonistSmall moleculeApproved|Nutraceutical

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Related Diseases for C11orf80-FADS1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneC11orf80C0678213Complete hydatidiform mole1ORPHANET
TgeneFADS1C0009402Colorectal Carcinoma1CTD_human
TgeneFADS1C0009404Colorectal Neoplasms1CTD_human
TgeneFADS1C0019193Hepatitis, Toxic1CTD_human
TgeneFADS1C0024623Malignant neoplasm of stomach1CTD_human
TgeneFADS1C0038356Stomach Neoplasms1CTD_human
TgeneFADS1C0860207Drug-Induced Liver Disease1CTD_human
TgeneFADS1C1262760Hepatitis, Drug-Induced1CTD_human
TgeneFADS1C1708349Hereditary Diffuse Gastric Cancer1CTD_human
TgeneFADS1C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneFADS1C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneFADS1C4279912Chemically-Induced Liver Toxicity1CTD_human