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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C12orf5-PTPN6 (FusionGDB2 ID:10897)

Fusion Gene Summary for C12orf5-PTPN6

check button Fusion gene summary
Fusion gene informationFusion gene name: C12orf5-PTPN6
Fusion gene ID: 10897
HgeneTgene
Gene symbol

C12orf5

PTPN6

Gene ID

57103

5777

Gene nameTP53 induced glycolysis regulatory phosphataseprotein tyrosine phosphatase non-receptor type 6
SynonymsC12orf5|FR2BPHCP|HCPH|HPTP1C|PTP-1C|SH-PTP1|SHP-1|SHP-1L|SHP1
Cytomap

12p13.32

12p13.31

Type of geneprotein-codingprotein-coding
Descriptionfructose-2,6-bisphosphatase TIGARTP53-induced glycolysis and apoptosis regulatorfructose-2,6-bisphosphate 2-phosphataseprobable fructose-2,6-bisphosphatase TIGARtransactivated by NS3TP2 proteintyrosine-protein phosphatase non-receptor type 6hematopoietic cell phosphatasehematopoietic cell protein-tyrosine phosphataseprotein-tyrosine phosphatase 1Cprotein-tyrosine phosphatase SHP-1
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000179259, ENST00000537251, 
ENST00000399448, ENST00000447931, 
ENST00000318974, ENST00000456013, 
ENST00000539029, 
Fusion gene scores* DoF score5 X 3 X 3=456 X 8 X 4=192
# samples 78
** MAII scorelog2(7/45*10)=0.637429920615292
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C12orf5 [Title/Abstract] AND PTPN6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC12orf5(4430469)-PTPN6(7060771), # samples:1
C12orf5(4430469)-PTPN6(7060772), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneC12orf5

GO:0006003

fructose 2,6-bisphosphate metabolic process

19015259

HgeneC12orf5

GO:0006974

cellular response to DNA damage stimulus

25928429

HgeneC12orf5

GO:0030388

fructose 1,6-bisphosphate metabolic process

19015259

HgeneC12orf5

GO:0043069

negative regulation of programmed cell death

23185017

HgeneC12orf5

GO:0071279

cellular response to cobalt ion

25928429

HgeneC12orf5

GO:0071456

cellular response to hypoxia

23185017

HgeneC12orf5

GO:1903301

positive regulation of hexokinase activity

23185017

TgenePTPN6

GO:0006470

protein dephosphorylation

11266449

TgenePTPN6

GO:0018108

peptidyl-tyrosine phosphorylation

9285411|18802077

TgenePTPN6

GO:0030154

cell differentiation

11266449

TgenePTPN6

GO:0070372

regulation of ERK1 and ERK2 cascade

11266449


check buttonFusion gene breakpoints across C12orf5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PTPN6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A3TOC12orf5chr12

4430469

+PTPN6chr12

7060771

+
ChimerDB4SARCTCGA-FX-A3TO-01AC12orf5chr12

4430469

-PTPN6chr12

7060772

+


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Fusion Gene ORF analysis for C12orf5-PTPN6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000179259ENST00000399448C12orf5chr12

4430469

+PTPN6chr12

7060771

+
5CDS-intronENST00000179259ENST00000447931C12orf5chr12

4430469

+PTPN6chr12

7060771

+
5CDS-intronENST00000179259ENST00000318974C12orf5chr12

4430469

+PTPN6chr12

7060771

+
5CDS-intronENST00000179259ENST00000456013C12orf5chr12

4430469

+PTPN6chr12

7060771

+
5CDS-intronENST00000179259ENST00000539029C12orf5chr12

4430469

+PTPN6chr12

7060771

+
intron-3CDSENST00000537251ENST00000399448C12orf5chr12

4430469

+PTPN6chr12

7060771

+
intron-intronENST00000537251ENST00000447931C12orf5chr12

4430469

+PTPN6chr12

7060771

+
intron-intronENST00000537251ENST00000318974C12orf5chr12

4430469

+PTPN6chr12

7060771

+
intron-intronENST00000537251ENST00000456013C12orf5chr12

4430469

+PTPN6chr12

7060771

+
intron-intronENST00000537251ENST00000539029C12orf5chr12

4430469

+PTPN6chr12

7060771

+
In-frameENST00000179259ENST00000399448C12orf5chr12

4430469

-PTPN6chr12

7060772

+
5CDS-intronENST00000179259ENST00000447931C12orf5chr12

4430469

-PTPN6chr12

7060772

+
5CDS-intronENST00000179259ENST00000318974C12orf5chr12

4430469

-PTPN6chr12

7060772

+
5CDS-intronENST00000179259ENST00000456013C12orf5chr12

4430469

-PTPN6chr12

7060772

+
5CDS-intronENST00000179259ENST00000539029C12orf5chr12

4430469

-PTPN6chr12

7060772

+
intron-3CDSENST00000537251ENST00000399448C12orf5chr12

4430469

-PTPN6chr12

7060772

+
intron-intronENST00000537251ENST00000447931C12orf5chr12

4430469

-PTPN6chr12

7060772

+
intron-intronENST00000537251ENST00000318974C12orf5chr12

4430469

-PTPN6chr12

7060772

+
intron-intronENST00000537251ENST00000456013C12orf5chr12

4430469

-PTPN6chr12

7060772

+
intron-intronENST00000537251ENST00000539029C12orf5chr12

4430469

-PTPN6chr12

7060772

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000179259C12orf5chr124430469+ENST00000399448PTPN6chr127060771+209599671878603
ENST00000179259C12orf5chr124430469-ENST00000399448PTPN6chr127060772+209599671878603

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000179259ENST00000399448C12orf5chr124430469+PTPN6chr127060771+0.0157828130.98421717
ENST00000179259ENST00000399448C12orf5chr124430469-PTPN6chr127060772+0.0157828130.98421717

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Fusion Genomic Features for C12orf5-PTPN6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C12orf5chr124430469+PTPN6chr127060771+2.98E-060.999997
C12orf5chr124430469+PTPN6chr127060771+2.98E-060.999997

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C12orf5-PTPN6


check button Go to

FGviewer for the breakpoints of chr12:4430469-chr12:7060771

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTPN6chr12:4430469chr12:7060771ENST00000318974016110_2132.6666666666666665574.6666666666666DomainSH2 2
TgenePTPN6chr12:4430469chr12:7060771ENST00000318974016244_5152.6666666666666665574.6666666666666DomainTyrosine-protein phosphatase
TgenePTPN6chr12:4430469chr12:7060771ENST000003189740164_1002.6666666666666665574.6666666666666DomainSH2 1
TgenePTPN6chr12:4430469chr12:7060771ENST00000399448016110_2134.666666666666667607.3333333333334DomainSH2 2
TgenePTPN6chr12:4430469chr12:7060771ENST00000399448016244_5154.666666666666667607.3333333333334DomainTyrosine-protein phosphatase
TgenePTPN6chr12:4430469chr12:7060771ENST000003994480164_1004.666666666666667607.3333333333334DomainSH2 1
TgenePTPN6chr12:4430469chr12:7060771ENST00000447931015110_2130566.6666666666666DomainSH2 2
TgenePTPN6chr12:4430469chr12:7060771ENST00000447931015244_5150566.6666666666666DomainTyrosine-protein phosphatase
TgenePTPN6chr12:4430469chr12:7060771ENST000004479310154_1000566.6666666666666DomainSH2 1
TgenePTPN6chr12:4430469chr12:7060771ENST00000456013016110_2132.6666666666666665605.3333333333334DomainSH2 2
TgenePTPN6chr12:4430469chr12:7060771ENST00000456013016244_5152.6666666666666665605.3333333333334DomainTyrosine-protein phosphatase
TgenePTPN6chr12:4430469chr12:7060771ENST000004560130164_1002.6666666666666665605.3333333333334DomainSH2 1
TgenePTPN6chr12:4430469chr12:7060772ENST00000318974016110_2132.6666666666666665574.6666666666666DomainSH2 2
TgenePTPN6chr12:4430469chr12:7060772ENST00000318974016244_5152.6666666666666665574.6666666666666DomainTyrosine-protein phosphatase
TgenePTPN6chr12:4430469chr12:7060772ENST000003189740164_1002.6666666666666665574.6666666666666DomainSH2 1
TgenePTPN6chr12:4430469chr12:7060772ENST00000399448016110_2134.666666666666667607.3333333333334DomainSH2 2
TgenePTPN6chr12:4430469chr12:7060772ENST00000399448016244_5154.666666666666667607.3333333333334DomainTyrosine-protein phosphatase
TgenePTPN6chr12:4430469chr12:7060772ENST000003994480164_1004.666666666666667607.3333333333334DomainSH2 1
TgenePTPN6chr12:4430469chr12:7060772ENST00000447931015110_2130566.6666666666666DomainSH2 2
TgenePTPN6chr12:4430469chr12:7060772ENST00000447931015244_5150566.6666666666666DomainTyrosine-protein phosphatase
TgenePTPN6chr12:4430469chr12:7060772ENST000004479310154_1000566.6666666666666DomainSH2 1
TgenePTPN6chr12:4430469chr12:7060772ENST00000456013016110_2132.6666666666666665605.3333333333334DomainSH2 2
TgenePTPN6chr12:4430469chr12:7060772ENST00000456013016244_5152.6666666666666665605.3333333333334DomainTyrosine-protein phosphatase
TgenePTPN6chr12:4430469chr12:7060772ENST000004560130164_1002.6666666666666665605.3333333333334DomainSH2 1
TgenePTPN6chr12:4430469chr12:7060771ENST00000318974016453_4592.6666666666666665574.6666666666666RegionSubstrate binding
TgenePTPN6chr12:4430469chr12:7060771ENST00000399448016453_4594.666666666666667607.3333333333334RegionSubstrate binding
TgenePTPN6chr12:4430469chr12:7060771ENST00000447931015453_4590566.6666666666666RegionSubstrate binding
TgenePTPN6chr12:4430469chr12:7060771ENST00000456013016453_4592.6666666666666665605.3333333333334RegionSubstrate binding
TgenePTPN6chr12:4430469chr12:7060772ENST00000318974016453_4592.6666666666666665574.6666666666666RegionSubstrate binding
TgenePTPN6chr12:4430469chr12:7060772ENST00000399448016453_4594.666666666666667607.3333333333334RegionSubstrate binding
TgenePTPN6chr12:4430469chr12:7060772ENST00000447931015453_4590566.6666666666666RegionSubstrate binding
TgenePTPN6chr12:4430469chr12:7060772ENST00000456013016453_4592.6666666666666665605.3333333333334RegionSubstrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for C12orf5-PTPN6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000179259_ENST00000399448_TCGA-FX-A3TO_C12orf5_chr12_4430469_+_PTPN6_chr12_7060771_length(transcript)=2095nt_BP=99nt
GGGGAGGTAGCCCGCAGTGCAGGGGCAGCGCGGCGCGGGGCCACCGACGGGACGCGGCTCCGGGAACATGGCTCGCTTCGCTCTGACTGT
TGTCCGGCAGTGGTTTCACCGAGACCTCAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCG
GCCCAGTCGCAAGAACCAGGGTGACTTCTCGCTCTCCGTCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTT
CTATGACCTGTATGGAGGGGAGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGA
CGGCACCATCATCCACCTCAAGTACCCGCTGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGC
AGAGACGCTGCTGCAGGCCAAGGGCGAGCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCT
CAGTGACCAGCCCAAGGCTGGCCCAGGCTCCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGG
TTTGGAGACCTTCGACAGCCTCACGGACCTGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCG
GCAGCCGTACTATGCCACGAGGGTGAATGCGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGC
CAAGGCTGGCTTCTGGGAGGAGTTTGAGAGTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAA
CAAGGGCAAGAACCGCTACAAGAACATTCTCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGA
CTACATCAATGCCAACTACATCAAGAACCAGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGC
CACGGTCAATGACTTCTGGCAGATGGCGTGGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAA
ATGCGTCCCATACTGGCCCGAGGTGGGCATGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATA
CAAACTCCGTACCTTACAGGTCTCCCCGCTGGACAATGGAGACCTGATTCGGGAGATCTGGCATTACCAGTACCTGAGCTGGCCCGACCA
TGGGGTCCCCAGTGAGCCTGGGGGTGTCCTCAGCTTCCTGGACCAGATCAACCAGCGGCAGGAAAGTCTGCCTCACGCAGGGCCCATCAT
CGTGCACTGCAGCGCCGGCATCGGCCGCACAGGCACCATCATTGTCATCGACATGCTCATGGAGAACATCTCCACCAAGGGCCTGGACTG
TGACATTGACATCCAGAAGACCATCCAGATGGTGCGGGCGCAGCGCTCGGGCATGGTGCAGACGGAGGCGCAGTACAAGTTCATCTACGT
GGCCATCGCCCAGTTCATTGAAACCACTAAGAAGAAGCTGGAGGTCCTGCAGTCGCAGAAGGGCCAGGAGTCGGAGTACGGGAACATCAC
CTATCCCCCAGCCATGAAGAATGCCCATGCCAAGGCCTCCCGCACCTCGTCCAAACACAAGGAGGATGTGTATGAGAACCTGCACACTAA
GAACAAGAGGGAGGAGAAAGTGAAGAAGCAGCGGTCAGCAGACAAGGAGAAGAGCAAGGGTTCCCTCAAGAGGAAGTGAGCGGTGCTGTC
CTCAGGTGGCCATGCCTCAGCCCTGACCCTGTGGAAGCATTTCGCGATGGACAGACTCACAACCTGAACCTAGGAGTGCCCCATTCTTTT
GTAATTTAAATGGCTGCATCCCCCCCACCTCTCCCTGACCCTGTATATAGCCCAGCCAGGCCCCAGGCAGGGCCAACCCTTCTCCTCTTG

>In-frame_ENST00000179259_ENST00000399448_TCGA-FX-A3TO_C12orf5_chr12_4430469_+_PTPN6_chr12_7060771_length(amino acids)=603AA_start in transcript=67_stop in transcript=1878
MARFALTVVRQWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQ
QGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCE
GGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQR
LEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTR
EVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQES
LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQ

--------------------------------------------------------------
>In-frame_ENST00000179259_ENST00000399448_TCGA-FX-A3TO-01A_C12orf5_chr12_4430469_-_PTPN6_chr12_7060772_length(transcript)=2095nt_BP=99nt
GGGGAGGTAGCCCGCAGTGCAGGGGCAGCGCGGCGCGGGGCCACCGACGGGACGCGGCTCCGGGAACATGGCTCGCTTCGCTCTGACTGT
TGTCCGGCAGTGGTTTCACCGAGACCTCAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGCCGAGGTGTCCACGGTAGCTTCCTGGCTCG
GCCCAGTCGCAAGAACCAGGGTGACTTCTCGCTCTCCGTCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTT
CTATGACCTGTATGGAGGGGAGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACTCAGCAGCAGGGTGTCCTGCAGGACCGCGA
CGGCACCATCATCCACCTCAAGTACCCGCTGAACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGC
AGAGACGCTGCTGCAGGCCAAGGGCGAGCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGCCAGCCTGGAGACTTCGTGCTTTCTGTGCT
CAGTGACCAGCCCAAGGCTGGCCCAGGCTCCCCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGG
TTTGGAGACCTTCGACAGCCTCACGGACCTGGTGGAGCATTTCAAGAAGACGGGGATTGAGGAGGCCTCAGGCGCCTTTGTCTACCTGCG
GCAGCCGTACTATGCCACGAGGGTGAATGCGGCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGC
CAAGGCTGGCTTCTGGGAGGAGTTTGAGAGTTTGCAGAAGCAGGAGGTGAAGAACTTGCACCAGCGTCTGGAAGGGCAGCGGCCAGAGAA
CAAGGGCAAGAACCGCTACAAGAACATTCTCCCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGA
CTACATCAATGCCAACTACATCAAGAACCAGCTGCTAGGCCCTGATGAGAACGCTAAGACCTACATCGCCAGCCAGGGTTGTCTGGAGGC
CACGGTCAATGACTTCTGGCAGATGGCGTGGCAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAA
ATGCGTCCCATACTGGCCCGAGGTGGGCATGCAGCGTGCTTATGGGCCCTACTCTGTGACCAACTGCGGGGAGCATGACACAACCGAATA
CAAACTCCGTACCTTACAGGTCTCCCCGCTGGACAATGGAGACCTGATTCGGGAGATCTGGCATTACCAGTACCTGAGCTGGCCCGACCA
TGGGGTCCCCAGTGAGCCTGGGGGTGTCCTCAGCTTCCTGGACCAGATCAACCAGCGGCAGGAAAGTCTGCCTCACGCAGGGCCCATCAT
CGTGCACTGCAGCGCCGGCATCGGCCGCACAGGCACCATCATTGTCATCGACATGCTCATGGAGAACATCTCCACCAAGGGCCTGGACTG
TGACATTGACATCCAGAAGACCATCCAGATGGTGCGGGCGCAGCGCTCGGGCATGGTGCAGACGGAGGCGCAGTACAAGTTCATCTACGT
GGCCATCGCCCAGTTCATTGAAACCACTAAGAAGAAGCTGGAGGTCCTGCAGTCGCAGAAGGGCCAGGAGTCGGAGTACGGGAACATCAC
CTATCCCCCAGCCATGAAGAATGCCCATGCCAAGGCCTCCCGCACCTCGTCCAAACACAAGGAGGATGTGTATGAGAACCTGCACACTAA
GAACAAGAGGGAGGAGAAAGTGAAGAAGCAGCGGTCAGCAGACAAGGAGAAGAGCAAGGGTTCCCTCAAGAGGAAGTGAGCGGTGCTGTC
CTCAGGTGGCCATGCCTCAGCCCTGACCCTGTGGAAGCATTTCGCGATGGACAGACTCACAACCTGAACCTAGGAGTGCCCCATTCTTTT
GTAATTTAAATGGCTGCATCCCCCCCACCTCTCCCTGACCCTGTATATAGCCCAGCCAGGCCCCAGGCAGGGCCAACCCTTCTCCTCTTG

>In-frame_ENST00000179259_ENST00000399448_TCGA-FX-A3TO-01A_C12orf5_chr12_4430469_-_PTPN6_chr12_7060772_length(amino acids)=603AA_start in transcript=67_stop in transcript=1878
MARFALTVVRQWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYDLYGGEKFATLTELVEYYTQQ
QGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCE
GGRYTVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEVKNLHQR
LEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTR
EVEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQES
LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C12orf5-PTPN6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C12orf5-PTPN6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C12orf5-PTPN6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTPN6C0006663Calcinosis1CTD_human
TgenePTPN6C0018824Heart valve disease1CTD_human
TgenePTPN6C0035228Respiratory Hypersensitivity1CTD_human
TgenePTPN6C0036341Schizophrenia1PSYGENET
TgenePTPN6C0263628Tumoral calcinosis1CTD_human
TgenePTPN6C0521174Microcalcification1CTD_human