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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:C1orf63-POLR2A (FusionGDB2 ID:11435) |
Fusion Gene Summary for C1orf63-POLR2A |
Fusion gene summary |
Fusion gene information | Fusion gene name: C1orf63-POLR2A | Fusion gene ID: 11435 | Hgene | Tgene | Gene symbol | C1orf63 | POLR2A | Gene ID | 57035 | 5430 |
Gene name | arginine and serine rich protein 1 | RNA polymerase II subunit A | |
Synonyms | C1orf63|NPD014 | NEDHIB|POLR2|POLRA|RPB1|RPBh1|RPO2|RPOL2|RpIILS|hRPB220|hsRPB1 | |
Cytomap | 1p36.11 | 17p13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | arginine/serine-rich protein 1UPF0471 protein C1orf63 | DNA-directed RNA polymerase II subunit RPB1DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunitDNA-directed RNA polymerase II subunit ADNA-directed RNA polymerase III largest subunitRNA polymerase II subunit B1RNA-directed | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000243189, ENST00000417642, ENST00000431849, ENST00000450820, | ENST00000322644, ENST00000572844, | |
Fusion gene scores | * DoF score | 8 X 4 X 2=64 | 7 X 7 X 2=98 |
# samples | 8 | 7 | |
** MAII score | log2(8/64*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/98*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: C1orf63 [Title/Abstract] AND POLR2A [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | C1orf63(25571641)-POLR2A(7402358), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | POLR2A | GO:0006366 | transcription by RNA polymerase II | 9852112 |
Tgene | POLR2A | GO:0033120 | positive regulation of RNA splicing | 21536736 |
Fusion gene breakpoints across C1orf63 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across POLR2A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-CD-8531-01A | C1orf63 | chr1 | 25571641 | - | POLR2A | chr17 | 7402358 | + |
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Fusion Gene ORF analysis for C1orf63-POLR2A |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000243189 | ENST00000322644 | C1orf63 | chr1 | 25571641 | - | POLR2A | chr17 | 7402358 | + |
In-frame | ENST00000243189 | ENST00000572844 | C1orf63 | chr1 | 25571641 | - | POLR2A | chr17 | 7402358 | + |
intron-3CDS | ENST00000417642 | ENST00000322644 | C1orf63 | chr1 | 25571641 | - | POLR2A | chr17 | 7402358 | + |
intron-3CDS | ENST00000417642 | ENST00000572844 | C1orf63 | chr1 | 25571641 | - | POLR2A | chr17 | 7402358 | + |
In-frame | ENST00000431849 | ENST00000322644 | C1orf63 | chr1 | 25571641 | - | POLR2A | chr17 | 7402358 | + |
In-frame | ENST00000431849 | ENST00000572844 | C1orf63 | chr1 | 25571641 | - | POLR2A | chr17 | 7402358 | + |
intron-3CDS | ENST00000450820 | ENST00000322644 | C1orf63 | chr1 | 25571641 | - | POLR2A | chr17 | 7402358 | + |
intron-3CDS | ENST00000450820 | ENST00000572844 | C1orf63 | chr1 | 25571641 | - | POLR2A | chr17 | 7402358 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000243189 | C1orf63 | chr1 | 25571641 | - | ENST00000322644 | POLR2A | chr17 | 7402358 | + | 5964 | 949 | 229 | 5526 | 1765 |
ENST00000243189 | C1orf63 | chr1 | 25571641 | - | ENST00000572844 | POLR2A | chr17 | 7402358 | + | 1552 | 949 | 229 | 1314 | 361 |
ENST00000431849 | C1orf63 | chr1 | 25571641 | - | ENST00000322644 | POLR2A | chr17 | 7402358 | + | 5899 | 884 | 164 | 5461 | 1765 |
ENST00000431849 | C1orf63 | chr1 | 25571641 | - | ENST00000572844 | POLR2A | chr17 | 7402358 | + | 1487 | 884 | 164 | 1249 | 361 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000243189 | ENST00000322644 | C1orf63 | chr1 | 25571641 | - | POLR2A | chr17 | 7402358 | + | 0.000761472 | 0.9992385 |
ENST00000243189 | ENST00000572844 | C1orf63 | chr1 | 25571641 | - | POLR2A | chr17 | 7402358 | + | 0.036888774 | 0.9631112 |
ENST00000431849 | ENST00000322644 | C1orf63 | chr1 | 25571641 | - | POLR2A | chr17 | 7402358 | + | 0.000718232 | 0.9992818 |
ENST00000431849 | ENST00000572844 | C1orf63 | chr1 | 25571641 | - | POLR2A | chr17 | 7402358 | + | 0.03857388 | 0.9614261 |
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Fusion Genomic Features for C1orf63-POLR2A |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
C1orf63 | chr1 | 25571640 | - | POLR2A | chr17 | 7402357 | + | 4.66E-07 | 0.9999995 |
C1orf63 | chr1 | 25571640 | - | POLR2A | chr17 | 7402357 | + | 4.66E-07 | 0.9999995 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for C1orf63-POLR2A |
Go to FGviewer for the breakpoints of chr1:25571641-chr17:7402358 - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
. | . |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | C1orf63 | chr1:25571641 | chr17:7402358 | ENST00000243189 | - | 3 | 5 | 18_169 | 224.0 | 291.0 | Compositional bias | Note=Arg/Ser-rich |
Hgene | C1orf63 | chr1:25571641 | chr17:7402358 | ENST00000431849 | - | 3 | 4 | 18_169 | 224.0 | 227.0 | Compositional bias | Note=Arg/Ser-rich |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1593_1960 | 445.0 | 1971.0 | Region | Note=C-terminal domain (CTD)%3B 52 X 7 AA approximate tandem repeats of Y-[ST]-P-[STQ]-[ST]-P-[SRTEVKGN] | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 833_845 | 445.0 | 1971.0 | Region | Note=Bridging helix | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1593_1599 | 445.0 | 1971.0 | Repeat | Note=1 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1600_1606 | 445.0 | 1971.0 | Repeat | Note=2%3B approximate | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1608_1614 | 445.0 | 1971.0 | Repeat | Note=3 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1615_1621 | 445.0 | 1971.0 | Repeat | Note=4 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1622_1628 | 445.0 | 1971.0 | Repeat | Note=5 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1629_1635 | 445.0 | 1971.0 | Repeat | Note=6 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1636_1642 | 445.0 | 1971.0 | Repeat | Note=7 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1643_1649 | 445.0 | 1971.0 | Repeat | Note=8 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1650_1656 | 445.0 | 1971.0 | Repeat | Note=9 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1657_1663 | 445.0 | 1971.0 | Repeat | Note=10 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1664_1670 | 445.0 | 1971.0 | Repeat | Note=11 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1671_1677 | 445.0 | 1971.0 | Repeat | Note=12 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1678_1684 | 445.0 | 1971.0 | Repeat | Note=13 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1685_1691 | 445.0 | 1971.0 | Repeat | Note=14 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1692_1698 | 445.0 | 1971.0 | Repeat | Note=15 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1699_1705 | 445.0 | 1971.0 | Repeat | Note=16 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1706_1712 | 445.0 | 1971.0 | Repeat | Note=17 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1713_1719 | 445.0 | 1971.0 | Repeat | Note=18 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1720_1726 | 445.0 | 1971.0 | Repeat | Note=19 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1727_1733 | 445.0 | 1971.0 | Repeat | Note=20 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1734_1740 | 445.0 | 1971.0 | Repeat | Note=21 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1741_1747 | 445.0 | 1971.0 | Repeat | Note=22 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1748_1754 | 445.0 | 1971.0 | Repeat | Note=23 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1755_1761 | 445.0 | 1971.0 | Repeat | Note=24 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1762_1768 | 445.0 | 1971.0 | Repeat | Note=25 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1769_1775 | 445.0 | 1971.0 | Repeat | Note=26 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1776_1782 | 445.0 | 1971.0 | Repeat | Note=27 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1783_1789 | 445.0 | 1971.0 | Repeat | Note=28 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1790_1796 | 445.0 | 1971.0 | Repeat | Note=29 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1797_1803 | 445.0 | 1971.0 | Repeat | Note=30 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1804_1810 | 445.0 | 1971.0 | Repeat | Note=31 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1811_1817 | 445.0 | 1971.0 | Repeat | Note=32 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1818_1824 | 445.0 | 1971.0 | Repeat | Note=33 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1825_1831 | 445.0 | 1971.0 | Repeat | Note=34 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1832_1838 | 445.0 | 1971.0 | Repeat | Note=35 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1839_1845 | 445.0 | 1971.0 | Repeat | Note=36 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1846_1852 | 445.0 | 1971.0 | Repeat | Note=37 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1853_1859 | 445.0 | 1971.0 | Repeat | Note=38 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1860_1866 | 445.0 | 1971.0 | Repeat | Note=39 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1867_1873 | 445.0 | 1971.0 | Repeat | Note=40 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1874_1880 | 445.0 | 1971.0 | Repeat | Note=41 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1881_1887 | 445.0 | 1971.0 | Repeat | Note=42 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1888_1894 | 445.0 | 1971.0 | Repeat | Note=43 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1895_1901 | 445.0 | 1971.0 | Repeat | Note=44 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1902_1908 | 445.0 | 1971.0 | Repeat | Note=45 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1909_1915 | 445.0 | 1971.0 | Repeat | Note=46 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1916_1922 | 445.0 | 1971.0 | Repeat | Note=47 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1923_1929 | 445.0 | 1971.0 | Repeat | Note=48 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1930_1936 | 445.0 | 1971.0 | Repeat | Note=49 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1940_1946 | 445.0 | 1971.0 | Repeat | Note=50 | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1947_1953 | 445.0 | 1971.0 | Repeat | Note=51%3B approximate | |
Tgene | POLR2A | chr1:25571641 | chr17:7402358 | ENST00000322644 | 7 | 29 | 1954_1960 | 445.0 | 1971.0 | Repeat | Note=52%3B approximate |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for C1orf63-POLR2A |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>In-frame_ENST00000243189_ENST00000322644_TCGA-CD-8531-01A_C1orf63_chr1_25571641_-_POLR2A_chr17_7402358_length(transcript)=5964nt_BP=949nt ATCTCTGCGCATGCGCCGGGGGCCAGCTTCTGGTACTTTTGACGCGTCTGCTAACGTAGTCCCTCAGTGCGCATCCGGACGTAGGAGGTG GAGGTTGTGGAATTCGCCGTTCGAAAGCAGGGACTAAAAGCCCCACTTCGTCTTACGTTCCGAAAGGAAGGCGTCTGTTGAGCCTTTCTC TCAGTCGTGAGGGAGGCGTCGACGGCGTGCGGAAGTCCTGAGTTGAGGCTTGCGGGATCCTTTCCGGAGAAAGCGCAGGCTAAAGCCGCA GGTGAAGATGTCCAACTACGTGAACGACATGTGGCCGGGCTCGCCGCAGGAGAAGGATTCGCCCTCGACCTCGCGGTCGGGCGGGTCCAG CCGGCTGTCGTCGCGGTCTAGGAGCCGCTCTTTTTCCAGAAGCTCTCGGTCCCATTCCCGCGTCTCGAGCCGGTTTTCGTCCAGGAGTCG GAGGAGCAAGTCCAGGTCCCGTTCCCGAAGGCGCCACCAGCGGAAGTACAGGCGCTACTCGCGGTCATACTCGCGGAGCCGGTCGCGATC CCGCAGCCGCCGTTACCGAGAGAGGCGCTACGGGTTCACCAGGAGATACTACCGGTCTCCTTCGCGGTACCGGTCCCGGTCCCGTAGCAG GTCGCGCTCTCGGGGAAGGTCGTACTGCGGAAGGGCGTACGCGATCGCGCGGGGACAGCGCTACTACGGCTTTGGTCGCACAGTGTACCC GGAGGAGCACAGCAGATGGAGGGACAGATCCAGGACGAGGTCGCGGAGCAGAACCCCCTTTCGCTTAAGTGAAAAAGATCGAATGGAGCT GTTAGAAATAGCAAAAACCAATGCAGCGAAAGCTCTAGGAACAACCAACATTGACTTGCCAGCTAGTCTCAGAACTGTTCCTTCAGCCAA AGAAACAAGCCGTGGAATAGGTGTATCAAGTAATGGTGCAAAGCCTGAAGTGGAACGGCACATGTGTGATGGGGACATTGTTATCTTCAA CCGGCAGCCAACTCTGCACAAAATGTCCATGATGGGGCATCGGGTCCGCATTCTCCCATGGTCTACCTTTCGCTTGAATCTTAGTGTGAC AACTCCGTACAATGCAGACTTTGACGGGGATGAGATGAACTTGCACCTGCCACAGTCTCTGGAGACGCGAGCAGAGATCCAGGAGCTGGC CATGGTTCCTCGCATGATTGTCACCCCCCAGAGCAATCGGCCTGTCATGGGTATTGTGCAGGACACACTCACAGCAGTGCGCAAATTCAC CAAGAGAGACGTCTTCCTGGAGCGGGGTGAAGTGATGAACCTCCTGATGTTCCTGTCGACGTGGGATGGGAAGGTCCCACAGCCGGCCAT CCTAAAGCCCCGGCCCCTGTGGACAGGCAAGCAAATCTTCTCCCTCATCATACCTGGTCACATCAATTGTATCCGTACCCACAGTACCCA TCCCGATGATGAAGACAGTGGCCCTTACAAGCACATCTCTCCTGGGGACACCAAGGTGGTGGTGGAGAATGGGGAGCTGATCATGGGCAT CCTGTGTAAGAAGTCTCTGGGCACGTCAGCTGGCTCCCTGGTCCACATCTCCTACCTAGAGATGGGTCATGACATCACTCGCCTCTTCTA CTCCAACATTCAGACTGTCATTAACAACTGGCTCCTCATCGAGGGTCATACTATTGGCATTGGGGACTCCATTGCTGATTCTAAGACTTA CCAGGACATTCAGAACACTATTAAGAAGGCCAAGCAGGACGTAATAGAGGTCATCGAGAAGGCACACAACAATGAGCTGGAGCCCACCCC AGGGAACACTCTGCGGCAGACGTTTGAGAATCAGGTGAACCGCATTCTTAACGATGCCCGAGACAAGACTGGCTCCTCTGCTCAGAAATC CCTGTCTGAATACAATAACTTCAAGTCTATGGTCGTGTCCGGAGCTAAAGGTTCCAAGATTAACATCTCCCAGGTCATTGCTGTCGTTGG ACAGCAGAACGTCGAGGGCAAGCGGATTCCATTTGGCTTCAAGCACCGGACTCTGCCTCACTTCATCAAGGATGACTACGGGCCTGAGAG CCGTGGCTTTGTGGAGAACTCCTACCTAGCCGGCCTCACACCCACTGAGTTCTTTTTCCACGCCATGGGGGGTCGTGAGGGGCTCATTGA CACGGCTGTCAAGACTGCTGAGACTGGATACATCCAGCGGCGGCTGATCAAGTCCATGGAGTCAGTGATGGTGAAGTACGACGCGACTGT GCGGAACTCCATCAACCAGGTGGTGCAGCTGCGCTACGGCGAAGACGGCCTGGCAGGCGAGAGCGTTGAGTTCCAGAACCTGGCTACGCT TAAGCCTTCCAACAAGGCTTTTGAGAAGAAGTTCCGCTTTGATTATACCAATGAGAGGGCCCTGCGGCGCACTCTGCAGGAGGACCTGGT GAAGGACGTGCTGAGCAACGCACACATCCAGAACGAGTTGGAGCGGGAATTTGAGCGGATGCGGGAGGATCGGGAGGTGCTCAGGGTCAT CTTCCCAACTGGAGACAGCAAGGTCGTCCTCCCCTGTAACCTGCTGCGGATGATCTGGAATGCTCAGAAAATCTTCCACATCAACCCACG CCTTCCCTCCGACCTGCACCCCATCAAAGTGGTGGAGGGAGTCAAGGAATTGAGCAAGAAGCTGGTGATTGTGAATGGGGATGACCCACT AAGTCGACAGGCCCAGGAAAATGCCACGCTGCTCTTCAACATCCACCTGCGGTCCACGTTGTGTTCCCGCCGCATGGCAGAGGAGTTTCG GCTCAGTGGGGAGGCCTTCGACTGGCTGCTTGGGGAGATTGAGTCCAAGTTCAACCAAGCCATTGCGCATCCCGGGGAAATGGTGGGGGC TCTGGCTGCGCAGTCCCTTGGAGAACCTGCCACCCAGATGACCTTGAATACCTTCCACTATGCTGGTGTGTCTGCCAAGAATGTGACGCT GGGTGTGCCCCGACTTAAGGAGCTCATCAACATTTCCAAGAAGCCAAAGACTCCTTCGCTTACTGTCTTCCTGTTGGGCCAGTCCGCTCG AGATGCTGAGAGAGCCAAGGATATTCTGTGCCGTCTGGAGCATACAACGTTGAGGAAGGTGACTGCCAACACAGCCATCTACTATGACCC CAACCCCCAGAGCACGGTGGTGGCAGAGGATCAGGAATGGGTGAATGTCTACTATGAAATGCCTGACTTTGATGTGGCCCGAATCTCCCC CTGGCTGTTGCGGGTGGAGCTGGATCGGAAGCACATGACTGACCGGAAGCTCACCATGGAGCAGATTGCTGAAAAGATCAATGCTGGTTT TGGTGACGACTTGAACTGCATCTTTAATGATGACAATGCAGAGAAGCTGGTGCTCCGTATTCGCATCATGAACAGCGATGAGAACAAGAT GCAAGAGGAGGAAGAGGTGGTGGACAAGATGGATGATGATGTCTTCCTGCGCTGCATCGAGTCCAACATGCTGACAGATATGACCCTGCA GGGCATCGAGCAGATCAGCAAGGTGTACATGCACTTGCCACAGACAGACAACAAGAAGAAGATCATCATCACGGAGGATGGGGAATTCAA GGCCCTGCAGGAGTGGATCCTGGAGACGGACGGCGTGAGCTTGATGCGGGTGCTGAGTGAGAAGGACGTGGACCCCGTACGCACCACGTC CAATGACATTGTGGAGATCTTCACGGTGCTGGGCATTGAAGCCGTGCGGAAGGCCCTGGAGCGGGAGCTGTACCACGTCATCTCCTTTGA TGGCTCCTATGTCAATTACCGACACTTGGCTCTCTTGTGTGATACCATGACCTGTCGTGGCCACTTGATGGCCATCACCCGACACGGAGT CAACCGCCAGGACACAGGACCACTCATGAAGTGTTCCTTTGAGGAAACGGTGGACGTGCTTATGGAAGCAGCCGCACACGGTGAGAGTGA CCCCATGAAGGGGGTCTCTGAGAATATCATGCTGGGCCAGCTGGCTCCGGCCGGCACTGGCTGCTTTGACCTCCTGCTTGATGCAGAGAA GTGCAAGTATGGCATGGAGATCCCCACCAATATCCCCGGCCTGGGGGCTGCTGGACCCACCGGCATGTTCTTTGGTTCAGCACCCAGTCC CATGGGTGGAATCTCTCCTGCCATGACACCTTGGAACCAGGGTGCAACCCCTGCCTATGGCGCCTGGTCCCCCAGTGTTGGGAGTGGAAT GACCCCAGGGGCAGCCGGCTTCTCTCCCAGTGCTGCGTCAGATGCCAGCGGCTTCAGCCCAGGTTACTCCCCTGCCTGGTCTCCCACACC GGGCTCCCCGGGGTCCCCAGGTCCCTCAAGCCCCTACATCCCTTCACCAGGTGGTGCCATGTCTCCCAGCTACTCGCCAACGTCACCTGC CTACGAGCCCCGCTCTCCTGGGGGCTACACACCCCAGAGTCCCTCTTATTCCCCCACTTCACCCTCCTACTCCCCTACCTCTCCATCCTA TTCTCCAACCAGTCCCAACTATAGTCCCACATCACCCAGCTATTCGCCAACGTCACCCAGCTACTCACCGACCTCTCCCAGCTACTCACC CACCTCTCCCAGCTACTCGCCCACCTCTCCCAGCTACTCGCCCACCTCTCCCAGCTACTCACCCACTTCCCCTAGCTACTCGCCCACTTC CCCTAGCTACTCGCCAACGTCTCCCAGCTACTCACCGACATCTCCCAGCTACTCGCCAACTTCACCCAGCTATTCTCCCACTTCTCCCAG CTACTCACCTACCTCTCCAAGCTATTCACCCACCTCCCCCAGCTACTCACCCACTTCCCCAAGTTACTCACCCACCAGCCCGAACTATTC TCCAACCAGTCCCAATTACACCCCAACATCACCCAGCTACAGCCCGACATCACCCAGCTATTCACCTACTAGTCCCAACTACACACCTAC CAGCCCTAACTACAGCCCAACCTCTCCAAGCTACTCTCCAACATCACCCAGCTATTCCCCGACCTCACCAAGTTACTCCCCTTCCAGCCC ACGATACACACCACAGTCTCCAACCTATACCCCAAGCTCACCCAGCTACAGCCCCAGCTCGCCCAGCTACAGCCCAGCCTCACCCAAGTA CACCCCAACCAGTCCTTCTTACAGTCCCAGCTCCCCAGAGTATACCCCAACCTCTCCCAAGTACTCACCTACCAGTCCCAAATATTCACC CACCTCTCCCAAGTACTCGCCTACCAGTCCCACCTATTCACCCACCACCCCAAAATACTCCCCAACATCTCCTACTTATTCCCCAACCTC TCCAGTCTACACCCCAACCTCTCCCAAGTACTCACCTACTAGCCCCACTTACTCGCCCACTTCCCCCAAGTACTCGCCCACCAGCCCCAC CTACTCGCCCACCTCCCCCAAAGGCTCAACCTACTCTCCCACTTCCCCTGGTTACTCGCCCACCAGCCCCACCTACAGTCTCACAAGCCC GGCTATCAGCCCGGATGACAGTGACGAGGAGAACTGAGGGCACGTGGGGTGCGGCAGCGGGCTAGGGCCCAGGGCAGCTTGCCCGTGCTG CTGTGCAGTTCTTGCCTCCCTCACGGGGCGTCACCCCCAGCCCAGCTCCGTTGTACATAAATGCCTTGTGGCAGAGCTCCCGGTGAACTT CTGGATCCCGTTTCTGATGCAGACTCTTGTCTTGTTCTCCACTTGTGCTGTTAGAACTCACTGGCCCAGTGGTGTTCTCACTCCTACCCC ACCCACCCCCTGCCTGTCCCCAAATTGAAGATCCTTCCTTGCCTGTGGCTTGATGCGGGGCGGGTAAAGGGTATTTTAACTTAGGGGTAG TTCCTGCTGTGAGTGGTTACAGCTGATCCTCGGGAAGAACAAAGCTAAAGCTGCCTTTTGTCTGTTATTTTATTTTTTTGAAGTTTAAAT >In-frame_ENST00000243189_ENST00000322644_TCGA-CD-8531-01A_C1orf63_chr1_25571641_-_POLR2A_chr17_7402358_length(amino acids)=1765AA_start in transcript=229_stop in transcript=5526 MRDPFRRKRRLKPQVKMSNYVNDMWPGSPQEKDSPSTSRSGGSSRLSSRSRSRSFSRSSRSHSRVSSRFSSRSRRSKSRSRSRRRHQRKY RRYSRSYSRSRSRSRSRRYRERRYGFTRRYYRSPSRYRSRSRSRSRSRGRSYCGRAYAIARGQRYYGFGRTVYPEEHSRWRDRSRTRSRS RTPFRLSEKDRMELLEIAKTNAAKALGTTNIDLPASLRTVPSAKETSRGIGVSSNGAKPEVERHMCDGDIVIFNRQPTLHKMSMMGHRVR ILPWSTFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERGEVMNLLM FLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHI SYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRIL NDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTE FFFHAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYT NERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKE LSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMTLN TFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNV YYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNSDENKMQEEEEVVDKMDDDVFL RCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVR KALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAP AGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTGMFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDAS GFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSP TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS PTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSY SPSSPSYSPASPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPT -------------------------------------------------------------- >In-frame_ENST00000243189_ENST00000572844_TCGA-CD-8531-01A_C1orf63_chr1_25571641_-_POLR2A_chr17_7402358_length(transcript)=1552nt_BP=949nt ATCTCTGCGCATGCGCCGGGGGCCAGCTTCTGGTACTTTTGACGCGTCTGCTAACGTAGTCCCTCAGTGCGCATCCGGACGTAGGAGGTG GAGGTTGTGGAATTCGCCGTTCGAAAGCAGGGACTAAAAGCCCCACTTCGTCTTACGTTCCGAAAGGAAGGCGTCTGTTGAGCCTTTCTC TCAGTCGTGAGGGAGGCGTCGACGGCGTGCGGAAGTCCTGAGTTGAGGCTTGCGGGATCCTTTCCGGAGAAAGCGCAGGCTAAAGCCGCA GGTGAAGATGTCCAACTACGTGAACGACATGTGGCCGGGCTCGCCGCAGGAGAAGGATTCGCCCTCGACCTCGCGGTCGGGCGGGTCCAG CCGGCTGTCGTCGCGGTCTAGGAGCCGCTCTTTTTCCAGAAGCTCTCGGTCCCATTCCCGCGTCTCGAGCCGGTTTTCGTCCAGGAGTCG GAGGAGCAAGTCCAGGTCCCGTTCCCGAAGGCGCCACCAGCGGAAGTACAGGCGCTACTCGCGGTCATACTCGCGGAGCCGGTCGCGATC CCGCAGCCGCCGTTACCGAGAGAGGCGCTACGGGTTCACCAGGAGATACTACCGGTCTCCTTCGCGGTACCGGTCCCGGTCCCGTAGCAG GTCGCGCTCTCGGGGAAGGTCGTACTGCGGAAGGGCGTACGCGATCGCGCGGGGACAGCGCTACTACGGCTTTGGTCGCACAGTGTACCC GGAGGAGCACAGCAGATGGAGGGACAGATCCAGGACGAGGTCGCGGAGCAGAACCCCCTTTCGCTTAAGTGAAAAAGATCGAATGGAGCT GTTAGAAATAGCAAAAACCAATGCAGCGAAAGCTCTAGGAACAACCAACATTGACTTGCCAGCTAGTCTCAGAACTGTTCCTTCAGCCAA AGAAACAAGCCGTGGAATAGGTGTATCAAGTAATGGTGCAAAGCCTGAAGTGGAACGGCACATGTGTGATGGGGACATTGTTATCTTCAA CCGGCAGCCAACTCTGCACAAAATGTCCATGATGGGGCATCGGGTCCGCATTCTCCCATGGTCTACCTTTCGCTTGAATCTTAGTGTGAC AACTCCGTACAATGCAGACTTTGACGGGGATGAGATGAACTTGCACCTGCCACAGTCTCTGGAGACGCGAGCAGAGATCCAGGAGCTGGC CATGGTTCCTCGCATGATTGTCACCCCCCAGAGCAATCGGCCTGTCATGGGTATTGTGCAGGACACACTCACAGCAGTGCGCAAATTCAC CAAGAGAGACGTCTTCCTGGAGCGGGTGTGTGGTCCAAATGGAAACCTGGCTTAAGTGGGCAGTGGGGCTCTGGGGTGCAAGGTGGAGGC TAGAGAGGAAGAGCTGTGTTTTTTTTCCTGACTTACCCAGCAGTGGTCTGTGAGATTGTCTTTTCTGGTGGGCGAACAAAAAGGGGGTTA GGAAAACTCAGGCCAAAAAGGTGTAAGGCGTTAATTCCCCATTTAATTCCTTAAAATTTCATGTAATACCAGGTATTGCCTGTAAAGGAA >In-frame_ENST00000243189_ENST00000572844_TCGA-CD-8531-01A_C1orf63_chr1_25571641_-_POLR2A_chr17_7402358_length(amino acids)=361AA_start in transcript=229_stop in transcript=1314 MRDPFRRKRRLKPQVKMSNYVNDMWPGSPQEKDSPSTSRSGGSSRLSSRSRSRSFSRSSRSHSRVSSRFSSRSRRSKSRSRSRRRHQRKY RRYSRSYSRSRSRSRSRRYRERRYGFTRRYYRSPSRYRSRSRSRSRSRGRSYCGRAYAIARGQRYYGFGRTVYPEEHSRWRDRSRTRSRS RTPFRLSEKDRMELLEIAKTNAAKALGTTNIDLPASLRTVPSAKETSRGIGVSSNGAKPEVERHMCDGDIVIFNRQPTLHKMSMMGHRVR ILPWSTFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERVCGPNGNL -------------------------------------------------------------- >In-frame_ENST00000431849_ENST00000322644_TCGA-CD-8531-01A_C1orf63_chr1_25571641_-_POLR2A_chr17_7402358_length(transcript)=5899nt_BP=884nt AGTGCGCATCCGGACGTAGGAGGTGGAGGTTGTGGAATTCGCCGTTCGAAAGCAGGGACTAAAAGCCCCACTTCGTCTTACGTTCCGAAA GGAAGGCGTCTGTTGAGCCTTTCTCTCAGTCGTGAGGGAGGCGTCGACGGCGTGCGGAAGTCCTGAGTTGAGGCTTGCGGGATCCTTTCC GGAGAAAGCGCAGGCTAAAGCCGCAGGTGAAGATGTCCAACTACGTGAACGACATGTGGCCGGGCTCGCCGCAGGAGAAGGATTCGCCCT CGACCTCGCGGTCGGGCGGGTCCAGCCGGCTGTCGTCGCGGTCTAGGAGCCGCTCTTTTTCCAGAAGCTCTCGGTCCCATTCCCGCGTCT CGAGCCGGTTTTCGTCCAGGAGTCGGAGGAGCAAGTCCAGGTCCCGTTCCCGAAGGCGCCACCAGCGGAAGTACAGGCGCTACTCGCGGT CATACTCGCGGAGCCGGTCGCGATCCCGCAGCCGCCGTTACCGAGAGAGGCGCTACGGGTTCACCAGGAGATACTACCGGTCTCCTTCGC GGTACCGGTCCCGGTCCCGTAGCAGGTCGCGCTCTCGGGGAAGGTCGTACTGCGGAAGGGCGTACGCGATCGCGCGGGGACAGCGCTACT ACGGCTTTGGTCGCACAGTGTACCCGGAGGAGCACAGCAGATGGAGGGACAGATCCAGGACGAGGTCGCGGAGCAGAACCCCCTTTCGCT TAAGTGAAAAAGATCGAATGGAGCTGTTAGAAATAGCAAAAACCAATGCAGCGAAAGCTCTAGGAACAACCAACATTGACTTGCCAGCTA GTCTCAGAACTGTTCCTTCAGCCAAAGAAACAAGCCGTGGAATAGGTGTATCAAGTAATGGTGCAAAGCCTGAAGTGGAACGGCACATGT GTGATGGGGACATTGTTATCTTCAACCGGCAGCCAACTCTGCACAAAATGTCCATGATGGGGCATCGGGTCCGCATTCTCCCATGGTCTA CCTTTCGCTTGAATCTTAGTGTGACAACTCCGTACAATGCAGACTTTGACGGGGATGAGATGAACTTGCACCTGCCACAGTCTCTGGAGA CGCGAGCAGAGATCCAGGAGCTGGCCATGGTTCCTCGCATGATTGTCACCCCCCAGAGCAATCGGCCTGTCATGGGTATTGTGCAGGACA CACTCACAGCAGTGCGCAAATTCACCAAGAGAGACGTCTTCCTGGAGCGGGGTGAAGTGATGAACCTCCTGATGTTCCTGTCGACGTGGG ATGGGAAGGTCCCACAGCCGGCCATCCTAAAGCCCCGGCCCCTGTGGACAGGCAAGCAAATCTTCTCCCTCATCATACCTGGTCACATCA ATTGTATCCGTACCCACAGTACCCATCCCGATGATGAAGACAGTGGCCCTTACAAGCACATCTCTCCTGGGGACACCAAGGTGGTGGTGG AGAATGGGGAGCTGATCATGGGCATCCTGTGTAAGAAGTCTCTGGGCACGTCAGCTGGCTCCCTGGTCCACATCTCCTACCTAGAGATGG GTCATGACATCACTCGCCTCTTCTACTCCAACATTCAGACTGTCATTAACAACTGGCTCCTCATCGAGGGTCATACTATTGGCATTGGGG ACTCCATTGCTGATTCTAAGACTTACCAGGACATTCAGAACACTATTAAGAAGGCCAAGCAGGACGTAATAGAGGTCATCGAGAAGGCAC ACAACAATGAGCTGGAGCCCACCCCAGGGAACACTCTGCGGCAGACGTTTGAGAATCAGGTGAACCGCATTCTTAACGATGCCCGAGACA AGACTGGCTCCTCTGCTCAGAAATCCCTGTCTGAATACAATAACTTCAAGTCTATGGTCGTGTCCGGAGCTAAAGGTTCCAAGATTAACA TCTCCCAGGTCATTGCTGTCGTTGGACAGCAGAACGTCGAGGGCAAGCGGATTCCATTTGGCTTCAAGCACCGGACTCTGCCTCACTTCA TCAAGGATGACTACGGGCCTGAGAGCCGTGGCTTTGTGGAGAACTCCTACCTAGCCGGCCTCACACCCACTGAGTTCTTTTTCCACGCCA TGGGGGGTCGTGAGGGGCTCATTGACACGGCTGTCAAGACTGCTGAGACTGGATACATCCAGCGGCGGCTGATCAAGTCCATGGAGTCAG TGATGGTGAAGTACGACGCGACTGTGCGGAACTCCATCAACCAGGTGGTGCAGCTGCGCTACGGCGAAGACGGCCTGGCAGGCGAGAGCG TTGAGTTCCAGAACCTGGCTACGCTTAAGCCTTCCAACAAGGCTTTTGAGAAGAAGTTCCGCTTTGATTATACCAATGAGAGGGCCCTGC GGCGCACTCTGCAGGAGGACCTGGTGAAGGACGTGCTGAGCAACGCACACATCCAGAACGAGTTGGAGCGGGAATTTGAGCGGATGCGGG AGGATCGGGAGGTGCTCAGGGTCATCTTCCCAACTGGAGACAGCAAGGTCGTCCTCCCCTGTAACCTGCTGCGGATGATCTGGAATGCTC AGAAAATCTTCCACATCAACCCACGCCTTCCCTCCGACCTGCACCCCATCAAAGTGGTGGAGGGAGTCAAGGAATTGAGCAAGAAGCTGG TGATTGTGAATGGGGATGACCCACTAAGTCGACAGGCCCAGGAAAATGCCACGCTGCTCTTCAACATCCACCTGCGGTCCACGTTGTGTT CCCGCCGCATGGCAGAGGAGTTTCGGCTCAGTGGGGAGGCCTTCGACTGGCTGCTTGGGGAGATTGAGTCCAAGTTCAACCAAGCCATTG CGCATCCCGGGGAAATGGTGGGGGCTCTGGCTGCGCAGTCCCTTGGAGAACCTGCCACCCAGATGACCTTGAATACCTTCCACTATGCTG GTGTGTCTGCCAAGAATGTGACGCTGGGTGTGCCCCGACTTAAGGAGCTCATCAACATTTCCAAGAAGCCAAAGACTCCTTCGCTTACTG TCTTCCTGTTGGGCCAGTCCGCTCGAGATGCTGAGAGAGCCAAGGATATTCTGTGCCGTCTGGAGCATACAACGTTGAGGAAGGTGACTG CCAACACAGCCATCTACTATGACCCCAACCCCCAGAGCACGGTGGTGGCAGAGGATCAGGAATGGGTGAATGTCTACTATGAAATGCCTG ACTTTGATGTGGCCCGAATCTCCCCCTGGCTGTTGCGGGTGGAGCTGGATCGGAAGCACATGACTGACCGGAAGCTCACCATGGAGCAGA TTGCTGAAAAGATCAATGCTGGTTTTGGTGACGACTTGAACTGCATCTTTAATGATGACAATGCAGAGAAGCTGGTGCTCCGTATTCGCA TCATGAACAGCGATGAGAACAAGATGCAAGAGGAGGAAGAGGTGGTGGACAAGATGGATGATGATGTCTTCCTGCGCTGCATCGAGTCCA ACATGCTGACAGATATGACCCTGCAGGGCATCGAGCAGATCAGCAAGGTGTACATGCACTTGCCACAGACAGACAACAAGAAGAAGATCA TCATCACGGAGGATGGGGAATTCAAGGCCCTGCAGGAGTGGATCCTGGAGACGGACGGCGTGAGCTTGATGCGGGTGCTGAGTGAGAAGG ACGTGGACCCCGTACGCACCACGTCCAATGACATTGTGGAGATCTTCACGGTGCTGGGCATTGAAGCCGTGCGGAAGGCCCTGGAGCGGG AGCTGTACCACGTCATCTCCTTTGATGGCTCCTATGTCAATTACCGACACTTGGCTCTCTTGTGTGATACCATGACCTGTCGTGGCCACT TGATGGCCATCACCCGACACGGAGTCAACCGCCAGGACACAGGACCACTCATGAAGTGTTCCTTTGAGGAAACGGTGGACGTGCTTATGG AAGCAGCCGCACACGGTGAGAGTGACCCCATGAAGGGGGTCTCTGAGAATATCATGCTGGGCCAGCTGGCTCCGGCCGGCACTGGCTGCT TTGACCTCCTGCTTGATGCAGAGAAGTGCAAGTATGGCATGGAGATCCCCACCAATATCCCCGGCCTGGGGGCTGCTGGACCCACCGGCA TGTTCTTTGGTTCAGCACCCAGTCCCATGGGTGGAATCTCTCCTGCCATGACACCTTGGAACCAGGGTGCAACCCCTGCCTATGGCGCCT GGTCCCCCAGTGTTGGGAGTGGAATGACCCCAGGGGCAGCCGGCTTCTCTCCCAGTGCTGCGTCAGATGCCAGCGGCTTCAGCCCAGGTT ACTCCCCTGCCTGGTCTCCCACACCGGGCTCCCCGGGGTCCCCAGGTCCCTCAAGCCCCTACATCCCTTCACCAGGTGGTGCCATGTCTC CCAGCTACTCGCCAACGTCACCTGCCTACGAGCCCCGCTCTCCTGGGGGCTACACACCCCAGAGTCCCTCTTATTCCCCCACTTCACCCT CCTACTCCCCTACCTCTCCATCCTATTCTCCAACCAGTCCCAACTATAGTCCCACATCACCCAGCTATTCGCCAACGTCACCCAGCTACT CACCGACCTCTCCCAGCTACTCACCCACCTCTCCCAGCTACTCGCCCACCTCTCCCAGCTACTCGCCCACCTCTCCCAGCTACTCACCCA CTTCCCCTAGCTACTCGCCCACTTCCCCTAGCTACTCGCCAACGTCTCCCAGCTACTCACCGACATCTCCCAGCTACTCGCCAACTTCAC CCAGCTATTCTCCCACTTCTCCCAGCTACTCACCTACCTCTCCAAGCTATTCACCCACCTCCCCCAGCTACTCACCCACTTCCCCAAGTT ACTCACCCACCAGCCCGAACTATTCTCCAACCAGTCCCAATTACACCCCAACATCACCCAGCTACAGCCCGACATCACCCAGCTATTCAC CTACTAGTCCCAACTACACACCTACCAGCCCTAACTACAGCCCAACCTCTCCAAGCTACTCTCCAACATCACCCAGCTATTCCCCGACCT CACCAAGTTACTCCCCTTCCAGCCCACGATACACACCACAGTCTCCAACCTATACCCCAAGCTCACCCAGCTACAGCCCCAGCTCGCCCA GCTACAGCCCAGCCTCACCCAAGTACACCCCAACCAGTCCTTCTTACAGTCCCAGCTCCCCAGAGTATACCCCAACCTCTCCCAAGTACT CACCTACCAGTCCCAAATATTCACCCACCTCTCCCAAGTACTCGCCTACCAGTCCCACCTATTCACCCACCACCCCAAAATACTCCCCAA CATCTCCTACTTATTCCCCAACCTCTCCAGTCTACACCCCAACCTCTCCCAAGTACTCACCTACTAGCCCCACTTACTCGCCCACTTCCC CCAAGTACTCGCCCACCAGCCCCACCTACTCGCCCACCTCCCCCAAAGGCTCAACCTACTCTCCCACTTCCCCTGGTTACTCGCCCACCA GCCCCACCTACAGTCTCACAAGCCCGGCTATCAGCCCGGATGACAGTGACGAGGAGAACTGAGGGCACGTGGGGTGCGGCAGCGGGCTAG GGCCCAGGGCAGCTTGCCCGTGCTGCTGTGCAGTTCTTGCCTCCCTCACGGGGCGTCACCCCCAGCCCAGCTCCGTTGTACATAAATGCC TTGTGGCAGAGCTCCCGGTGAACTTCTGGATCCCGTTTCTGATGCAGACTCTTGTCTTGTTCTCCACTTGTGCTGTTAGAACTCACTGGC CCAGTGGTGTTCTCACTCCTACCCCACCCACCCCCTGCCTGTCCCCAAATTGAAGATCCTTCCTTGCCTGTGGCTTGATGCGGGGCGGGT AAAGGGTATTTTAACTTAGGGGTAGTTCCTGCTGTGAGTGGTTACAGCTGATCCTCGGGAAGAACAAAGCTAAAGCTGCCTTTTGTCTGT >In-frame_ENST00000431849_ENST00000322644_TCGA-CD-8531-01A_C1orf63_chr1_25571641_-_POLR2A_chr17_7402358_length(amino acids)=1765AA_start in transcript=164_stop in transcript=5461 MRDPFRRKRRLKPQVKMSNYVNDMWPGSPQEKDSPSTSRSGGSSRLSSRSRSRSFSRSSRSHSRVSSRFSSRSRRSKSRSRSRRRHQRKY RRYSRSYSRSRSRSRSRRYRERRYGFTRRYYRSPSRYRSRSRSRSRSRGRSYCGRAYAIARGQRYYGFGRTVYPEEHSRWRDRSRTRSRS RTPFRLSEKDRMELLEIAKTNAAKALGTTNIDLPASLRTVPSAKETSRGIGVSSNGAKPEVERHMCDGDIVIFNRQPTLHKMSMMGHRVR ILPWSTFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERGEVMNLLM FLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHI SYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRIL NDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTE FFFHAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYT NERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKE LSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMTLN TFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNV YYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNSDENKMQEEEEVVDKMDDDVFL RCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVR KALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAP AGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTGMFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDAS GFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSP TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYS PTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSY SPSSPSYSPASPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPT -------------------------------------------------------------- >In-frame_ENST00000431849_ENST00000572844_TCGA-CD-8531-01A_C1orf63_chr1_25571641_-_POLR2A_chr17_7402358_length(transcript)=1487nt_BP=884nt AGTGCGCATCCGGACGTAGGAGGTGGAGGTTGTGGAATTCGCCGTTCGAAAGCAGGGACTAAAAGCCCCACTTCGTCTTACGTTCCGAAA GGAAGGCGTCTGTTGAGCCTTTCTCTCAGTCGTGAGGGAGGCGTCGACGGCGTGCGGAAGTCCTGAGTTGAGGCTTGCGGGATCCTTTCC GGAGAAAGCGCAGGCTAAAGCCGCAGGTGAAGATGTCCAACTACGTGAACGACATGTGGCCGGGCTCGCCGCAGGAGAAGGATTCGCCCT CGACCTCGCGGTCGGGCGGGTCCAGCCGGCTGTCGTCGCGGTCTAGGAGCCGCTCTTTTTCCAGAAGCTCTCGGTCCCATTCCCGCGTCT CGAGCCGGTTTTCGTCCAGGAGTCGGAGGAGCAAGTCCAGGTCCCGTTCCCGAAGGCGCCACCAGCGGAAGTACAGGCGCTACTCGCGGT CATACTCGCGGAGCCGGTCGCGATCCCGCAGCCGCCGTTACCGAGAGAGGCGCTACGGGTTCACCAGGAGATACTACCGGTCTCCTTCGC GGTACCGGTCCCGGTCCCGTAGCAGGTCGCGCTCTCGGGGAAGGTCGTACTGCGGAAGGGCGTACGCGATCGCGCGGGGACAGCGCTACT ACGGCTTTGGTCGCACAGTGTACCCGGAGGAGCACAGCAGATGGAGGGACAGATCCAGGACGAGGTCGCGGAGCAGAACCCCCTTTCGCT TAAGTGAAAAAGATCGAATGGAGCTGTTAGAAATAGCAAAAACCAATGCAGCGAAAGCTCTAGGAACAACCAACATTGACTTGCCAGCTA GTCTCAGAACTGTTCCTTCAGCCAAAGAAACAAGCCGTGGAATAGGTGTATCAAGTAATGGTGCAAAGCCTGAAGTGGAACGGCACATGT GTGATGGGGACATTGTTATCTTCAACCGGCAGCCAACTCTGCACAAAATGTCCATGATGGGGCATCGGGTCCGCATTCTCCCATGGTCTA CCTTTCGCTTGAATCTTAGTGTGACAACTCCGTACAATGCAGACTTTGACGGGGATGAGATGAACTTGCACCTGCCACAGTCTCTGGAGA CGCGAGCAGAGATCCAGGAGCTGGCCATGGTTCCTCGCATGATTGTCACCCCCCAGAGCAATCGGCCTGTCATGGGTATTGTGCAGGACA CACTCACAGCAGTGCGCAAATTCACCAAGAGAGACGTCTTCCTGGAGCGGGTGTGTGGTCCAAATGGAAACCTGGCTTAAGTGGGCAGTG GGGCTCTGGGGTGCAAGGTGGAGGCTAGAGAGGAAGAGCTGTGTTTTTTTTCCTGACTTACCCAGCAGTGGTCTGTGAGATTGTCTTTTC TGGTGGGCGAACAAAAAGGGGGTTAGGAAAACTCAGGCCAAAAAGGTGTAAGGCGTTAATTCCCCATTTAATTCCTTAAAATTTCATGTA >In-frame_ENST00000431849_ENST00000572844_TCGA-CD-8531-01A_C1orf63_chr1_25571641_-_POLR2A_chr17_7402358_length(amino acids)=361AA_start in transcript=164_stop in transcript=1249 MRDPFRRKRRLKPQVKMSNYVNDMWPGSPQEKDSPSTSRSGGSSRLSSRSRSRSFSRSSRSHSRVSSRFSSRSRRSKSRSRSRRRHQRKY RRYSRSYSRSRSRSRSRRYRERRYGFTRRYYRSPSRYRSRSRSRSRSRGRSYCGRAYAIARGQRYYGFGRTVYPEEHSRWRDRSRTRSRS RTPFRLSEKDRMELLEIAKTNAAKALGTTNIDLPASLRTVPSAKETSRGIGVSSNGAKPEVERHMCDGDIVIFNRQPTLHKMSMMGHRVR ILPWSTFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERVCGPNGNL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for C1orf63-POLR2A |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for C1orf63-POLR2A |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for C1orf63-POLR2A |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | POLR2A | C0232466 | Feeding difficulties | 1 | GENOMICS_ENGLAND |
Tgene | POLR2A | C0557874 | Global developmental delay | 1 | GENOMICS_ENGLAND |
Tgene | POLR2A | C1858120 | Generalized hypotonia | 1 | GENOMICS_ENGLAND |
Tgene | POLR2A | C2677504 | AUTISM, SUSCEPTIBILITY TO, 15 | 1 | GENOMICS_ENGLAND |