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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C20orf194-ADRA1D (FusionGDB2 ID:11522)

Fusion Gene Summary for C20orf194-ADRA1D

check button Fusion gene summary
Fusion gene informationFusion gene name: C20orf194-ADRA1D
Fusion gene ID: 11522
HgeneTgene
Gene symbol

C20orf194

ADRA1D

Gene ID

25943

146

Gene namechromosome 20 open reading frame 194adrenoceptor alpha 1D
Synonyms-ADRA1|ADRA1A|ADRA1R|ALPHA1|DAR|dJ779E11.2
Cytomap

20p13

20p13

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C20orf194alpha-1D adrenergic receptoradrenergic, alpha -1D-, receptoradrenergic, alpha-1A-, receptoralpha-1A adrenergic receptoralpha-1D adrenoceptoralpha-1D adrenoreceptoralpha-adrenergic receptor 1a
Modification date2020031320200313
UniProtAcc.

P25100

Ensembl transtripts involved in fusion geneENST00000252032, ENST00000453730, 
ENST00000498079, 		ENST00000379453, 
Fusion gene scores* DoF score12 X 13 X 7=10924 X 3 X 3=36
# samples 135
** MAII scorelog2(13/1092*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: C20orf194 [Title/Abstract] AND ADRA1D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC20orf194(3388122)-ADRA1D(4202777), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C20orf194 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ADRA1D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KICHTCGA-KL-8328-01AC20orf194chr20

3388122

-ADRA1Dchr20

4202777

-
ChimerDB4KICHTCGA-KL-8328-01AC20orf194chr20

3388122

-ADRA1Dchr20

4202777

-
ChimerDB4KICHTCGA-KL-8328C20orf194chr20

3388122

-ADRA1Dchr20

4202777

-
ChimerDB4KICHTCGA-KL-8328-01AC20orf194chr20

3388122

-ADRA1Dchr20

4202777

-


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Fusion Gene ORF analysis for C20orf194-ADRA1D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000252032ENST00000379453C20orf194chr20

3388122

-ADRA1Dchr20

4202777

-
intron-3CDSENST00000453730ENST00000379453C20orf194chr20

3388122

-ADRA1Dchr20

4202777

-
intron-3CDSENST00000498079ENST00000379453C20orf194chr20

3388122

-ADRA1Dchr20

4202777

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000252032C20orf194chr203388122-ENST00000379453ADRA1Dchr204202777-16001516758250

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000252032ENST00000379453C20orf194chr203388122-ADRA1Dchr204202777-0.961386560.038613487

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Fusion Genomic Features for C20orf194-ADRA1D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C20orf194-ADRA1D


check button Go to

FGviewer for the breakpoints of chr20:3388122-chr20:4202777

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ADRA1D

P25100

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302422_428370.3333333333333573.0Compositional biasNote=Poly-Arg
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302374_380370.3333333333333573.0Topological domainExtracellular
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302406_572370.3333333333333573.0Topological domainCytoplasmic
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302381_405370.3333333333333573.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302122_133370.3333333333333573.0Topological domainCytoplasmic
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302160_169370.3333333333333573.0Topological domainExtracellular
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302193_213370.3333333333333573.0Topological domainCytoplasmic
TgeneADRA1Dchr20:3388122chr20:4202777ENST00000379453021_95370.3333333333333573.0Topological domainExtracellular
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302239_251370.3333333333333573.0Topological domainExtracellular
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302276_348370.3333333333333573.0Topological domainCytoplasmic
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302134_159370.3333333333333573.0TransmembraneHelical%3B Name%3D2
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302170_192370.3333333333333573.0TransmembraneHelical%3B Name%3D3
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302214_238370.3333333333333573.0TransmembraneHelical%3B Name%3D4
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302252_275370.3333333333333573.0TransmembraneHelical%3B Name%3D5
TgeneADRA1Dchr20:3388122chr20:4202777ENST0000037945302349_373370.3333333333333573.0TransmembraneHelical%3B Name%3D6
TgeneADRA1Dchr20:3388122chr20:4202777ENST000003794530296_121370.3333333333333573.0TransmembraneHelical%3B Name%3D1


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Fusion Gene Sequence for C20orf194-ADRA1D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000252032_ENST00000379453_TCGA-KL-8328-01A_C20orf194_chr20_3388122_-_ADRA1D_chr20_4202777_length(transcript)=1600nt_BP=151nt
GCCGCCCTGCGGGCAACTGAGACCCTCGCAGCTGCACCGTCCTCCTCCGCCGCCAGTCGTCCGCCGCCATGGACGTGTACCCCCCGCGCC
GGCAGGGGCTGCCCCGCGCTCGGTCCCCTGGCGGCTCCAGCCGCGGGTCACCCTCCGTCAGGCTCCTTGTTCCCGCAGCTGAAGCCATCG
GAGGGCGTCTTCAAGGTCATCTTCTGGCTCGGCTACTTCAACAGCTGCGTGAACCCGCTCATCTACCCCTGTTCCAGCCGCGAGTTCAAG
CGCGCCTTCCTCCGTCTCCTGCGCTGCCAGTGCCGTCGTCGCCGGCGCCGCCGCCCTCTCTGGCGTGTCTACGGCCACCACTGGCGGGCC
TCCACCAGCGGCCTGCGCCAGGACTGCGCCCCGAGTTCGGGCGACGCGCCCCCCGGAGCGCCGCTGGCCCTCACCGCGCTCCCCGACCCC
GACCCCGAACCCCCAGGCACGCCCGAGATGCAGGCTCCGGTCGCCAGCCGTCGAAAGCCACCCAGCGCCTTCCGCGAGTGGAGGCTGCTG
GGGCCGTTCCGGAGACCCACGACCCAGCTGCGCGCCAAAGTCTCCAGCCTGTCGCACAAGATCCGCGCCGGGGGCGCGCAGCGCGCAGAG
GCAGCGTGCGCCCAGCGCTCAGAGGTGGAGGCTGTGTCCCTAGGCGTCCCACACGAGGTGGCCGAGGGCGCCACCTGCCAGGCCTACGAA
TTGGCCGACTACAGCAACCTACGGGAGACCGATATTTAAGGACCCCAGAGCTAGGCCGCGGAGTGTGCTGGGCTTGGGGGTAAGGGGGAC
CAGAGAGGCGGGCTGGTGTTCTAAGAGCCCCCGTGCAAATCGGAGACCCGGAAACTGATCAGGGCAGCTGCTCTGTGACATCCCTGAGGA
ACTGGGCAGAGCTTGAGGCTGGAGCCCTTGAAAGGTGAAAAGTAGTGGGGCCCCCTGCTGGACTCAGGTGCCCAGAACTCTTTTCTTAGA
AGGGAGAGGCTGCGGGCTCCGTGGGGCCTTTTGCTCCCAATCCCTATTTGAGAAACACTGCCCCATCCTCCATGCCCTGAACCCTGAGTA
GACAGCCCCAAGCATGGCCAGGAAGGCCTGCCCCTCCTCTTCTGGGAAATAGGCACAGAAGCTTTGGCCGGCTACCCCAGTGCCTCCCTT
AGGGAAAAAGTCAGTGGGACCAGGGCTCCTCAGTGGACAAATTTCTCCTTCTTACTGCCAACTGGAGGAACCCAGTGGACCTACCACCAC
CCACAAGCTTTGGTGGCAGATTGTATAGCCGTCATACAAGCCTGCTGTATTTATCCATGGGCCCGCTGTCCGCCACCCAGGCTCCTCCGT
GCACACCCCATCACCTGGCCCCTACCCCTTATTACTTCCCCTCAAGGGCCTTACTGTTTACACTCTGTACATAGCTCATCGTGCCTGTGC
CCATCACTTCTTGCTGGGATTCCAAGCCACCAATTGGAGAGCTTTATTTGTCATTTTGAGACATATTTATTGGTAAGAGTACTTCTATTT

>In-frame_ENST00000252032_ENST00000379453_TCGA-KL-8328-01A_C20orf194_chr20_3388122_-_ADRA1D_chr20_4202777_length(amino acids)=250AA_start in transcript=6_stop in transcript=758
MRATETLAAAPSSSAASRPPPWTCTPRAGRGCPALGPLAAPAAGHPPSGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRA
FLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGP

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Fusion Gene PPI Analysis for C20orf194-ADRA1D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C20orf194-ADRA1D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneADRA1DP25100DB00211MidodrineAgonistSmall moleculeApproved
TgeneADRA1DP25100DB00211MidodrineAgonistSmall moleculeApproved
TgeneADRA1DP25100DB00248CabergolineBinderSmall moleculeApproved
TgeneADRA1DP25100DB00248CabergolineBinderSmall moleculeApproved
TgeneADRA1DP25100DB00298DapiprazoleAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00298DapiprazoleAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00321AmitriptylineAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00321AmitriptylineAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00368NorepinephrineAgonistSmall moleculeApproved
TgeneADRA1DP25100DB00368NorepinephrineAgonistSmall moleculeApproved
TgeneADRA1DP25100DB00388PhenylephrineAgonistSmall moleculeApproved
TgeneADRA1DP25100DB00388PhenylephrineAgonistSmall moleculeApproved
TgeneADRA1DP25100DB00457PrazosinAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00457PrazosinAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00458ImipramineAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00458ImipramineAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00540NortriptylineAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00540NortriptylineAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00575ClonidineAgonistSmall moleculeApproved
TgeneADRA1DP25100DB00575ClonidineAgonistSmall moleculeApproved
TgeneADRA1DP25100DB00590DoxazosinAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00590DoxazosinAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00661VerapamilAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00661VerapamilAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00692PhentolamineAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00692PhentolamineAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00696ErgotaminePartial agonistSmall moleculeApproved
TgeneADRA1DP25100DB00696ErgotaminePartial agonistSmall moleculeApproved
TgeneADRA1DP25100DB00800FenoldopamInhibitorSmall moleculeApproved
TgeneADRA1DP25100DB00800FenoldopamInhibitorSmall moleculeApproved
TgeneADRA1DP25100DB00925PhenoxybenzamineAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00925PhenoxybenzamineAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB01162TerazosinAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB01162TerazosinAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB04855DronedaroneAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB04855DronedaroneAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB06153PizotifenAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB06153PizotifenAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB06207SilodosinAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB06207SilodosinAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB11124RacepinephrineAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB11124RacepinephrineAntagonistSmall moleculeApproved
TgeneADRA1DP25100DB00346AlfuzosinAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB00346AlfuzosinAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB00622NicardipineAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB00622NicardipineAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB00706TamsulosinAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB00706TamsulosinAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB00723MethoxamineBinderSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB00723MethoxamineBinderSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB00908QuinidineAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB00908QuinidineAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB00935OxymetazolineAgonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB00935OxymetazolineAgonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB01136CarvedilolAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB01136CarvedilolAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB01142DoxepinAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB01142DoxepinAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB01200BromocriptineAgonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB01200BromocriptineAgonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB01403MethotrimeprazineAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB01403MethotrimeprazineAntagonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB06262DroxidopaAgonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB06262DroxidopaAgonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB06694XylometazolineAgonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB06694XylometazolineAgonistSmall moleculeApproved|Investigational
TgeneADRA1DP25100DB01186PergolideAgonistSmall moleculeApproved|Investigational|Vet_approved|Withdrawn
TgeneADRA1DP25100DB01186PergolideAgonistSmall moleculeApproved|Investigational|Vet_approved|Withdrawn
TgeneADRA1DP25100DB06144SertindoleSmall moleculeApproved|Investigational|Withdrawn
TgeneADRA1DP25100DB06144SertindoleSmall moleculeApproved|Investigational|Withdrawn
TgeneADRA1DP25100DB00668EpinephrineAntagonistSmall moleculeApproved|Vet_approved
TgeneADRA1DP25100DB00668EpinephrineAntagonistSmall moleculeApproved|Vet_approved

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Related Diseases for C20orf194-ADRA1D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneADRA1DC1135196Heart Failure, Diastolic1CTD_human