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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C22orf34-CDCA7 (FusionGDB2 ID:11619)

Fusion Gene Summary for C22orf34-CDCA7

check button Fusion gene summary
Fusion gene informationFusion gene name: C22orf34-CDCA7
Fusion gene ID: 11619
HgeneTgene
Gene symbol

C22orf34

CDCA7

Gene ID

348645

83879

Gene namechromosome 22 open reading frame 34cell division cycle associated 7
Synonyms-ICF3|JPO1
Cytomap

22q13.33

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionputative uncharacterized protein C22orf34uncharacterized protein C22orf34cell division cycle-associated protein 7c-Myc target JPO1
Modification date2020031320200329
UniProtAcc.

Q96GN5

Ensembl transtripts involved in fusion geneENST00000498829, ENST00000400023, 
ENST00000405854, ENST00000444628, 
ENST00000347703, ENST00000392567, 
ENST00000306721, ENST00000410101, 
ENST00000410019, 
Fusion gene scores* DoF score6 X 3 X 4=724 X 3 X 3=36
# samples 64
** MAII scorelog2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: C22orf34 [Title/Abstract] AND CDCA7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC22orf34(50051053)-CDCA7(174223440), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCDCA7

GO:0042127

regulation of cell proliferation

11598121


check buttonFusion gene breakpoints across C22orf34 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CDCA7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5721-01AC22orf34chr22

50051053

-CDCA7chr2

174223440

+


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Fusion Gene ORF analysis for C22orf34-CDCA7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000498829ENST00000347703C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-3CDSENST00000498829ENST00000392567C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-3CDSENST00000498829ENST00000306721C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-3CDSENST00000498829ENST00000410101C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-intronENST00000498829ENST00000410019C22orf34chr22

50051053

-CDCA7chr2

174223440

+
In-frameENST00000400023ENST00000347703C22orf34chr22

50051053

-CDCA7chr2

174223440

+
In-frameENST00000400023ENST00000392567C22orf34chr22

50051053

-CDCA7chr2

174223440

+
In-frameENST00000400023ENST00000306721C22orf34chr22

50051053

-CDCA7chr2

174223440

+
In-frameENST00000400023ENST00000410101C22orf34chr22

50051053

-CDCA7chr2

174223440

+
5CDS-intronENST00000400023ENST00000410019C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-3CDSENST00000405854ENST00000347703C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-3CDSENST00000405854ENST00000392567C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-3CDSENST00000405854ENST00000306721C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-3CDSENST00000405854ENST00000410101C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-intronENST00000405854ENST00000410019C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-3CDSENST00000444628ENST00000347703C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-3CDSENST00000444628ENST00000392567C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-3CDSENST00000444628ENST00000306721C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-3CDSENST00000444628ENST00000410101C22orf34chr22

50051053

-CDCA7chr2

174223440

+
intron-intronENST00000444628ENST00000410019C22orf34chr22

50051053

-CDCA7chr2

174223440

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400023C22orf34chr2250051053-ENST00000347703CDCA7chr2174223440+2473138871232381
ENST00000400023C22orf34chr2250051053-ENST00000392567CDCA7chr2174223440+2410138871082331
ENST00000400023C22orf34chr2250051053-ENST00000306721CDCA7chr2174223440+2803138871469460
ENST00000400023C22orf34chr2250051053-ENST00000410101CDCA7chr2174223440+1394138871337416

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400023ENST00000347703C22orf34chr2250051053-CDCA7chr2174223440+0.0006337010.99936634
ENST00000400023ENST00000392567C22orf34chr2250051053-CDCA7chr2174223440+0.0005456520.9994543
ENST00000400023ENST00000306721C22orf34chr2250051053-CDCA7chr2174223440+0.0001422220.9998578
ENST00000400023ENST00000410101C22orf34chr2250051053-CDCA7chr2174223440+0.0032846760.9967153

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Fusion Genomic Features for C22orf34-CDCA7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C22orf34chr2250051052-CDCA7chr2174223439+0.0003952950.99960476
C22orf34chr2250051052-CDCA7chr2174223439+0.0003952950.99960476

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for C22orf34-CDCA7


check button Go to

FGviewer for the breakpoints of chr22:50051053-chr2:174223440

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CDCA7

Q96GN5

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1. {ECO:0000269|PubMed:15654081, ECO:0000269|PubMed:15994933, ECO:0000269|PubMed:16829576}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDCA7chr22:50051053chr2:174223440ENST00000306721010157_1867.0451.0Compositional biasNote=Arg-rich
TgeneCDCA7chr22:50051053chr2:174223440ENST0000034770309157_1867.0372.0Compositional biasNote=Arg-rich
TgeneCDCA7chr22:50051053chr2:174223440ENST0000039256708157_1867.0322.0Compositional biasNote=Arg-rich
TgeneCDCA7chr22:50051053chr2:174223440ENST00000306721010160_1767.0451.0MotifNuclear localization signal
TgeneCDCA7chr22:50051053chr2:174223440ENST0000034770309160_1767.0372.0MotifNuclear localization signal
TgeneCDCA7chr22:50051053chr2:174223440ENST0000039256708160_1767.0322.0MotifNuclear localization signal
TgeneCDCA7chr22:50051053chr2:174223440ENST00000306721010247_3717.0451.0RegionNote=Mediates transcriptional activity
TgeneCDCA7chr22:50051053chr2:174223440ENST0000034770309247_3717.0372.0RegionNote=Mediates transcriptional activity
TgeneCDCA7chr22:50051053chr2:174223440ENST0000039256708247_3717.0322.0RegionNote=Mediates transcriptional activity

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC22orf34chr22:50051053chr2:174223440ENST00000400023-1479_9818.333333333333332184.0Compositional biasNote=Cys-rich


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Fusion Gene Sequence for C22orf34-CDCA7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000400023_ENST00000347703_TCGA-CG-5721-01A_C22orf34_chr22_50051053_-_CDCA7_chr2_174223440_length(transcript)=2473nt_BP=138nt
CGTGTGCGGTCCCTCCCCCTCACGTTCTCTCTTCCTCTGCTCCGCCATGATGAGAAGCGCCTGCTTCCCCTTCCCCTTCCGCCATGATTG
TGTTTCCTGAGACCTCCCAGCCACGCTTCCTGTACAGCCTGCAGAACTCAGAAAGATCTCAGAGTAAAGAAGAACTTAAAGAAATTCAGA
TATGTGAAGTTGATTTCCATGGAAACCTCGTCATCCTCTGATGACAGTTGTGACAGCTTTGCTTCTGATAATTTTGCAAACACGAGGCTG
CAGTCAGTTCGGGAAGGCTGTAGGACCCGCAGCCAGTGCAGGCACTCTGGACCTCTCAGGGTGGCGATGAAGTTTCCAGCGCGGAGTACC
AGGGGAGCAACCAACAAAAAAGCAGAGTCCCGCCAGCCCTCAGAGAATTCTGTGACTGATTCCAACTCCGATTCAGAAGATGAAAGTGGA
ATGAATTTTTTGGAGAAAAGGGCTTTAAATATAAAGCAAAACAAAGCAATGCTTGCAAAACTCATGTCTGAATTAGAAAGCTTCCCTGGC
TCGTTCCGTGGAAGACATCCCCTCCCAGGCTCCGACTCACAATCAAGGAGACCGCGAAGGCGTACATTCCCGGGTGTTGCTTCCAGGAGA
AACCCTGAACGGAGAGCTCGTCCTCTTACCAGGTCAAGGTCCCGGATCCTCGGGTCCCTTGACGCTCTACCCATGGAGGAGGAGGAGGAA
GAGGATAAGTACATGTTGGTGAGAAAGAGGAAGACCGTGGATGGCTACATGAATGAAGATGACCTGCCCAGAAGCCGTCGCTCCAGATCA
TCCGTGACCCTTCCGCATATAATTCGCCCAGTGGAAGAAATTACAGAGGAGGAGTTGGAGAACGTCTGCAGCAATTCTCGAGAGAAGATA
TATAACCGTTCACTGGGCTCTACTTGTCATCAATGCCGTCAGAAGACTATTGATACCAAAACAAACTGCAGAAACCCAGACTGCTGGGGC
GTTCGAGGCCAGTTCTGTGGCCCCTGCCTTCGAAACCGTTATGGTGAAGAGGTCAGGGATGCTCTGCTGGATCCGAACTGGCATTGCCCG
CCTTGTCGAGGAATCTGCAACTGCAGTTTCTGCCGGCAGCGAGATGGACGGTGTGCGACTGGGGTCCTTGTGTATTTAGCCAAATATCAT
GGCTTTGGGAATGTGCATGCCTACTTGAAAAGCCTGAAACAGGAATTTGAAATGCAAGCATAATATCTGGAAAATTTGCTGCCTGCCTTC
TACTTCTCAAATCTTTCTTGTAAAAGTTTCCAATTTTTTCACTGAAACCTGAGTTAAAAATCTTGATGATCAGCCTGTTTCATAAGAAAC
TCCAATCAAGTTAATCTTAGCAGACATGTGTTTCTGGAGCATCACAGAAGGTATATTGCTAGTTACACTTTGCCCTCCTGCAGTTTCTTC
TCTGCTCCCAACCCCCATCTCACAGCATCCCCCTCTATTTCCAATGCTCCTCTCCAACCGCTTAGTTTCTGAATTTCTTTTAAATTACAG
TTTTATGAAAGCATATTTTATTTACTTGGTGTTGAAATAGCCCTCATAAAACCTAAGCACTTGGAAACACAATAATAGTATTAACTAACT
AGATCTATTGAATTTCAGAGAAGAGCCTTCTAACTTGTTTACACAAAAACGAGTATGATTTAGCATTCATACTAGTTGAAATTTTTAATA
GAATCAAGGCACAAAAGTCTTAAAACCATGTGGAAAAATTAGGTAATTATTGCAGATTGATGTCTCTCAATCCCATGTATTGCGCTTATG
TTACAAGTTGTTGTCACAGTTGAGACTTAATTTCTCCTAATTTCTTCTGCCCGAAGGGTAAGTGGTGCGTCCAGCTTACACAATCATAAT
TCAAAGGTTGGTGGGCAATGTAATACTTAATTAAAATAATGATGGAAGAGCTATCTGGAGATTATGAGTAAGCTGATTTGAATTTTCAGT
ATAAAACTTTAGTATAATTGTAGTTTGCAAAGTTTATTTCAGTTCACATGTAAGGTATTGCAAATAAATTCTTGGACAATTTTGTATGGA
AACTTGATATTAAAAACTAGTCTGTGGTTCTTTGCAGTTTCTTGTAAATTTATAAACCAGGCACAAGGTTCAAGTTTAGATTTTAAGCAC
TTTTATAACAATGATAAGTGCCTTTTTGGAGATGTAACTTTTAGCAGTTTGTTAACCTGACATCTCTGCCAGTCTAGTTTCTGGGCAGGT
TTCCTGTGTCAGTATTCCCCCTCCTCTTTGCATTAATCAAGGTATTTGGTAGAGGTGGAATCTAAGTGTTTGTATGTCCAATTTACTTGC
ATATGTAAACCATTGCTGTGCCATTCAATGTTTGATGCATAATTGGACCTTGAATCGATAAGTGTAAATACAGCTTTTGATCTGTAATGC

>In-frame_ENST00000400023_ENST00000347703_TCGA-CG-5721-01A_C22orf34_chr22_50051053_-_CDCA7_chr2_174223440_length(amino acids)=381AA_start in transcript=87_stop in transcript=1232
MCFLRPPSHASCTACRTQKDLRVKKNLKKFRYVKLISMETSSSSDDSCDSFASDNFANTRLQSVREGCRTRSQCRHSGPLRVAMKFPARS
TRGATNKKAESRQPSENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFRGRHPLPGSDSQSRRPRRRTFPGVASR
RNPERRARPLTRSRSRILGSLDALPMEEEEEEDKYMLVRKRKTVDGYMNEDDLPRSRRSRSSVTLPHIIRPVEEITEEELENVCSNSREK
IYNRSLGSTCHQCRQKTIDTKTNCRNPDCWGVRGQFCGPCLRNRYGEEVRDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKY

--------------------------------------------------------------
>In-frame_ENST00000400023_ENST00000392567_TCGA-CG-5721-01A_C22orf34_chr22_50051053_-_CDCA7_chr2_174223440_length(transcript)=2410nt_BP=138nt
CGTGTGCGGTCCCTCCCCCTCACGTTCTCTCTTCCTCTGCTCCGCCATGATGAGAAGCGCCTGCTTCCCCTTCCCCTTCCGCCATGATTG
TGTTTCCTGAGACCTCCCAGCCACGCTTCCTGTACAGCCTGCAGAACTCAGAAAGATCTCAGAGTAAAGAAGAACTTAAAGAAATTCAGA
TATGTGAAGTTGATTTCCATGGAAACCTCGTCATCCTCTGATGACAGTTGTGACAGCTTTGCTTCTGATAATTTTGCAAACACGAGGCTG
CAGTCAGTTCGGGAAGGCTGTAGGACCCGCAGCCAGTGCAGGCACTCTGGACCTCTCAGGGTGGCGATGAAGTTTCCAGCGCGGAGTACC
AGGGGAGCAACCAACAAAAAAGCAGAGTCCCGCCAGCCCTCAGAGAATTCTGTGACTGATTCCAACTCCGATTCAGAAGATGAAAGTGGA
ATGAATTTTTTGGAGAAAAGGGCTTTAAATATAAAGCAAAACAAAGCAATGCTTGCAAAACTCATGTCTGAATTAGAAAGCTTCCCTGGC
TCGTTCCGTGGAAGACATCCCCTCCCAGGCTCCGACTCACAATCAAGGAGACCGCGAAGGCGTACATTCCCGGGTGTTGCTTCCAGGAGA
AACCCTGAACGGAGAGCTCGTCCTCTTACCAGGTCAAGGTCCCGGATCCTCGGGTCCCTTGACGCTCTACCCATGGAGGAGGAGGAGGAA
GAGGATAAGTACATGTTGGTGAGAAAGAGGAAGACCGTGGATGGCTACATGAATGAAGATGACCTGCCCAGAAGCCGTCGCTCCAGATCA
TCCGTGACCCTTCCGCATATAATTCGCCCAGTGGAAGAAATTACAGAGGAGGAGTTGGAGAACGTCTGCAGCAATTCTCGAGAGAAGATA
TATAACCGTTCACTGAACTGGCATTGCCCGCCTTGTCGAGGAATCTGCAACTGCAGTTTCTGCCGGCAGCGAGATGGACGGTGTGCGACT
GGGGTCCTTGTGTATTTAGCCAAATATCATGGCTTTGGGAATGTGCATGCCTACTTGAAAAGCCTGAAACAGGAATTTGAAATGCAAGCA
TAATATCTGGAAAATTTGCTGCCTGCCTTCTACTTCTCAAATCTTTCTTGTAAAAGTTTCCAATTTTTTCACTGAAACCTGAGTTAAAAA
TCTTGATGATCAGCCTGTTTCATAAGAAACTCCAATCAAGTTAATCTTAGCAGACATGTGTTTCTGGAGCATCACAGAAGGTATATTGCT
AGTTACACTTTGCCCTCCTGCAGTTTCTTCTCTGCTCCCAACCCCCATCTCACAGCATCCCCCTCTATTTCCAATGCTCCTCTCCAACCG
CTTAGTTTCTGAATTTCTTTTAAATTACAGTTTTATGAAAGCATATTTTATTTACTTGGTGTTGAAATAGCCCTCATAAAACCTAAGCAC
TTGGAAACACAATAATAGTATTAACTAACTAGATCTATTGAATTTCAGAGAAGAGCCTTCTAACTTGTTTACACAAAAACGAGTATGATT
TAGCATTCATACTAGTTGAAATTTTTAATAGAATCAAGGCACAAAAGTCTTAAAACCATGTGGAAAAATTAGGTAATTATTGCAGATTGA
TGTCTCTCAATCCCATGTATTGCGCTTATGTTACAAGTTGTTGTCACAGTTGAGACTTAATTTCTCCTAATTTCTTCTGCCCGAAGGGTA
AGTGGTGCGTCCAGCTTACACAATCATAATTCAAAGGTTGGTGGGCAATGTAATACTTAATTAAAATAATGATGGAAGAGCTATCTGGAG
ATTATGAGTAAGCTGATTTGAATTTTCAGTATAAAACTTTAGTATAATTGTAGTTTGCAAAGTTTATTTCAGTTCACATGTAAGGTATTG
CAAATAAATTCTTGGACAATTTTGTATGGAAACTTGATATTAAAAACTAGTCTGTGGTTCTTTGCAGTTTCTTGTAAATTTATAAACCAG
GCACAAGGTTCAAGTTTAGATTTTAAGCACTTTTATAACAATGATAAGTGCCTTTTTGGAGATGTAACTTTTAGCAGTTTGTTAACCTGA
CATCTCTGCCAGTCTAGTTTCTGGGCAGGTTTCCTGTGTCAGTATTCCCCCTCCTCTTTGCATTAATCAAGGTATTTGGTAGAGGTGGAA
TCTAAGTGTTTGTATGTCCAATTTACTTGCATATGTAAACCATTGCTGTGCCATTCAATGTTTGATGCATAATTGGACCTTGAATCGATA
AGTGTAAATACAGCTTTTGATCTGTAATGCTTTTATACAAAAGTTTATTTTAATAATAAAATGTTTGTTCTAACTTGTCTGCTTTTTTAA

>In-frame_ENST00000400023_ENST00000392567_TCGA-CG-5721-01A_C22orf34_chr22_50051053_-_CDCA7_chr2_174223440_length(amino acids)=331AA_start in transcript=87_stop in transcript=1082
MCFLRPPSHASCTACRTQKDLRVKKNLKKFRYVKLISMETSSSSDDSCDSFASDNFANTRLQSVREGCRTRSQCRHSGPLRVAMKFPARS
TRGATNKKAESRQPSENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFRGRHPLPGSDSQSRRPRRRTFPGVASR
RNPERRARPLTRSRSRILGSLDALPMEEEEEEDKYMLVRKRKTVDGYMNEDDLPRSRRSRSSVTLPHIIRPVEEITEEELENVCSNSREK

--------------------------------------------------------------
>In-frame_ENST00000400023_ENST00000306721_TCGA-CG-5721-01A_C22orf34_chr22_50051053_-_CDCA7_chr2_174223440_length(transcript)=2803nt_BP=138nt
CGTGTGCGGTCCCTCCCCCTCACGTTCTCTCTTCCTCTGCTCCGCCATGATGAGAAGCGCCTGCTTCCCCTTCCCCTTCCGCCATGATTG
TGTTTCCTGAGACCTCCCAGCCACGCTTCCTGTACAGCCTGCAGAACTCAGAAAGATCTCAGAGTAAAGAAGAACTTAAAGAAATTCAGA
TATGTGAAGTTGATTTCCATGGAAACCTCGTCATCCTCTGATGACAGTTGTGACAGCTTTGCTTCTGATAATTTTGCAAACACGAAACCT
AAATTCAGGTCAGATATCAGTGAAGAACTGGCAAATGTTTTTTATGAGGACTCTGATAATGAATCTTTCTGCGGCTTTTCAGAAAGTGAG
GTGCAAGATGTATTAGACCATTGTGGATTTTTACAGAAACCAAGGCCAGATGTCACTAACGAACTGGCCGGTATTTTTCATGCCGACTCT
GACGATGAATCATTTTGCGGTTTCTCAGAGAGTGAGATACAAGATGGAATGAGGCTGCAGTCAGTTCGGGAAGGCTGTAGGACCCGCAGC
CAGTGCAGGCACTCTGGACCTCTCAGGGTGGCGATGAAGTTTCCAGCGCGGAGTACCAGGGGAGCAACCAACAAAAAAGCAGAGTCCCGC
CAGCCCTCAGAGAATTCTGTGACTGATTCCAACTCCGATTCAGAAGATGAAAGTGGAATGAATTTTTTGGAGAAAAGGGCTTTAAATATA
AAGCAAAACAAAGCAATGCTTGCAAAACTCATGTCTGAATTAGAAAGCTTCCCTGGCTCGTTCCGTGGAAGACATCCCCTCCCAGGCTCC
GACTCACAATCAAGGAGACCGCGAAGGCGTACATTCCCGGGTGTTGCTTCCAGGAGAAACCCTGAACGGAGAGCTCGTCCTCTTACCAGG
TCAAGGTCCCGGATCCTCGGGTCCCTTGACGCTCTACCCATGGAGGAGGAGGAGGAAGAGGATAAGTACATGTTGGTGAGAAAGAGGAAG
ACCGTGGATGGCTACATGAATGAAGATGACCTGCCCAGAAGCCGTCGCTCCAGATCATCCGTGACCCTTCCGCATATAATTCGCCCAGTG
GAAGAAATTACAGAGGAGGAGTTGGAGAACGTCTGCAGCAATTCTCGAGAGAAGATATATAACCGTTCACTGGGCTCTACTTGTCATCAA
TGCCGTCAGAAGACTATTGATACCAAAACAAACTGCAGAAACCCAGACTGCTGGGGCGTTCGAGGCCAGTTCTGTGGCCCCTGCCTTCGA
AACCGTTATGGTGAAGAGGTCAGGGATGCTCTGCTGGATCCGAACTGGCATTGCCCGCCTTGTCGAGGAATCTGCAACTGCAGTTTCTGC
CGGCAGCGAGATGGACGGTGTGCGACTGGGGTCCTTGTGTATTTAGCCAAATATCATGGCTTTGGGAATGTGCATGCCTACTTGAAAAGC
CTGAAACAGGAATTTGAAATGCAAGCATAATATCTGGAAAATTTGCTGCCTGCCTTCTACTTCTCAAATCTTTCTTGTAAAAGTTTCCAA
TTTTTTCACTGAAACCTGAGTTAAAAATCTTGATGATCAGCCTGTTTCATAAGAAACTCCAATCAAGTTAATCTTAGCAGACATGTGTTT
CTGGAGCATCACAGAAGGTATATTGCTAGTTACACTTTGCCCTCCTGCAGTTTCTTCTCTGCTCCCAACCCCCATCTCACAGCATCCCCC
TCTATTTCCAATGCTCCTCTCCAACCGCTTAGTTTCTGAATTTCTTTTAAATTACAGTTTTATGAAAGCATATTTTATTTACTTGGTGTT
GAAATAGCCCTCATAAAACCTAAGCACTTGGAAACACAATAATAGTATTAACTAACTAGATCTATTGAATTTCAGAGAAGAGCCTTCTAA
CTTGTTTACACAAAAACGAGTATGATTTAGCATTCATACTAGTTGAAATTTTTAATAGAATCAAGGCACAAAAGTCTTAAAACCATGTGG
AAAAATTAGGTAATTATTGCAGATTGATGTCTCTCAATCCCATGTATTGCGCTTATGTTACAAGTTGTTGTCACAGTTGAGACTTAATTT
CTCCTAATTTCTTCTGCCCGAAGGGTAAGTGGTGCGTCCAGCTTACACAATCATAATTCAAAGGTTGGTGGGCAATGTAATACTTAATTA
AAATAATGATGGAAGAGCTATCTGGAGATTATGAGTAAGCTGATTTGAATTTTCAGTATAAAACTTTAGTATAATTGTAGTTTGCAAAGT
TTATTTCAGTTCACATGTAAGGTATTGCAAATAAATTCTTGGACAATTTTGTATGGAAACTTGATATTAAAAACTAGTCTGTGGTTCTTT
GCAGTTTCTTGTAAATTTATAAACCAGGCACAAGGTTCAAGTTTAGATTTTAAGCACTTTTATAACAATGATAAGTGCCTTTTTGGAGAT
GTAACTTTTAGCAGTTTGTTAACCTGACATCTCTGCCAGTCTAGTTTCTGGGCAGGTTTCCTGTGTCAGTATTCCCCCTCCTCTTTGCAT
TAATCAAGGTATTTGGTAGAGGTGGAATCTAAGTGTTTGTATGTCCAATTTACTTGCATATGTAAACCATTGCTGTGCCATTCAATGTTT
GATGCATAATTGGACCTTGAATCGATAAGTGTAAATACAGCTTTTGATCTGTAATGCTTTTATACAAAAGTTTATTTTAATAATAAAATG
TTTGTTCTAACTTGTCTGCTTTTTTAAAAATAATCTTACTGTACTTAATTCTAATTTTTTCCTCATATTTAAATAAAAGGCCATTTCCAC

>In-frame_ENST00000400023_ENST00000306721_TCGA-CG-5721-01A_C22orf34_chr22_50051053_-_CDCA7_chr2_174223440_length(amino acids)=460AA_start in transcript=87_stop in transcript=1469
MCFLRPPSHASCTACRTQKDLRVKKNLKKFRYVKLISMETSSSSDDSCDSFASDNFANTKPKFRSDISEELANVFYEDSDNESFCGFSES
EVQDVLDHCGFLQKPRPDVTNELAGIFHADSDDESFCGFSESEIQDGMRLQSVREGCRTRSQCRHSGPLRVAMKFPARSTRGATNKKAES
RQPSENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSELESFPGSFRGRHPLPGSDSQSRRPRRRTFPGVASRRNPERRARPLT
RSRSRILGSLDALPMEEEEEEDKYMLVRKRKTVDGYMNEDDLPRSRRSRSSVTLPHIIRPVEEITEEELENVCSNSREKIYNRSLGSTCH
QCRQKTIDTKTNCRNPDCWGVRGQFCGPCLRNRYGEEVRDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLK

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>In-frame_ENST00000400023_ENST00000410101_TCGA-CG-5721-01A_C22orf34_chr22_50051053_-_CDCA7_chr2_174223440_length(transcript)=1394nt_BP=138nt
CGTGTGCGGTCCCTCCCCCTCACGTTCTCTCTTCCTCTGCTCCGCCATGATGAGAAGCGCCTGCTTCCCCTTCCCCTTCCGCCATGATTG
TGTTTCCTGAGACCTCCCAGCCACGCTTCCTGTACAGCCTGCAGAACTCAGAAAGATCTCAGAGTAAAGAAGAACTTAAAGAAATTCAGA
TATGTGAAGTTGATTTCCATGGAAACCTCGTCATCCTCTGATGACAGTTGTGACAGCTTTGCTTCTGATAATTTTGCAAACACGAAACCA
AGGCCAGATGTCACTAACGAACTGGCCGGTATTTTTCATGCCGACTCTGACGATGAATCATTTTGCGGTTTCTCAGAGAGTGAGATACAA
GATGGAATGAGGCTGCAGTCAGTTCGGGAAGGCTGTAGGACCCGCAGCCAGTGCAGGCACTCTGGACCTCTCAGGGTGGCGATGAAGTTT
CCAGCGCGGAGTACCAGGGGAGCAACCAACAAAAAAGCAGAGTCCCGCCAGCCCTCAGAGAATTCTGTGACTGATTCCAACTCCGATTCA
GAAGATGAAAGTGGAATGAATTTTTTGGAGAAAAGGGCTTTAAATATAAAGCAAAACAAAGCAATGCTTGCAAAACTCATGTCTGAATTA
GAAAGCTTCCCTGGCTCGTTCCGTGGAAGACATCCCCTCCCAGGCTCCGACTCACAATCAAGGAGACCGCGAAGGCGTACATTCCCGGGT
GTTGCTTCCAGGAGAAACCCTGAACGGAGAGCTCGTCCTCTTACCAGGTCAAGGTCCCGGATCCTCGGGTCCCTTGACGCTCTACCCATG
GAGGAGGAGGAGGAAGAGGATAAGTACATGTTGGTGAGAAAGAGGAAGACCGTGGATGGCTACATGAATGAAGATGACCTGCCCAGAAGC
CGTCGCTCCAGATCATCCGTGACCCTTCCGCATATAATTCGCCCAGTGGAAGAAATTACAGAGGAGGAGTTGGAGAACGTCTGCAGCAAT
TCTCGAGAGAAGATATATAACCGTTCACTGGGCTCTACTTGTCATCAATGCCGTCAGAAGACTATTGATACCAAAACAAACTGCAGAAAC
CCAGACTGCTGGGGCGTTCGAGGCCAGTTCTGTGGCCCCTGCCTTCGAAACCGTTATGGTGAAGAGGTCAGGGATGCTCTGCTGGATCCG
AACTGGCATTGCCCGCCTTGTCGAGGAATCTGCAACTGCAGTTTCTGCCGGCAGCGAGATGGACGGTGTGCGACTGGGGTCCTTGTGTAT
TTAGCCAAATATCATGGCTTTGGGAATGTGCATGCCTACTTGAAAAGCCTGAAACAGGAATTTGAAATGCAAGCATAATATCTGGAAAAT

>In-frame_ENST00000400023_ENST00000410101_TCGA-CG-5721-01A_C22orf34_chr22_50051053_-_CDCA7_chr2_174223440_length(amino acids)=416AA_start in transcript=87_stop in transcript=1337
MCFLRPPSHASCTACRTQKDLRVKKNLKKFRYVKLISMETSSSSDDSCDSFASDNFANTKPRPDVTNELAGIFHADSDDESFCGFSESEI
QDGMRLQSVREGCRTRSQCRHSGPLRVAMKFPARSTRGATNKKAESRQPSENSVTDSNSDSEDESGMNFLEKRALNIKQNKAMLAKLMSE
LESFPGSFRGRHPLPGSDSQSRRPRRRTFPGVASRRNPERRARPLTRSRSRILGSLDALPMEEEEEEDKYMLVRKRKTVDGYMNEDDLPR
SRRSRSSVTLPHIIRPVEEITEEELENVCSNSREKIYNRSLGSTCHQCRQKTIDTKTNCRNPDCWGVRGQFCGPCLRNRYGEEVRDALLD

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Fusion Gene PPI Analysis for C22orf34-CDCA7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCDCA7chr22:50051053chr2:174223440ENST00000306721010146_1707.0451.0MYC
TgeneCDCA7chr22:50051053chr2:174223440ENST0000034770309146_1707.0372.0MYC
TgeneCDCA7chr22:50051053chr2:174223440ENST0000039256708146_1707.0322.0MYC


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C22orf34-CDCA7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C22orf34-CDCA7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCDCA7C0021831Intestinal Diseases1GENOMICS_ENGLAND
TgeneCDCA7C0086438Hypogammaglobulinemia1GENOMICS_ENGLAND
TgeneCDCA7C0398788Immunodeficiency syndrome, variable1GENOMICS_ENGLAND
TgeneCDCA7C2931456Prostate cancer, familial1CTD_human
TgeneCDCA7C3806482Recurrent respiratory infections1GENOMICS_ENGLAND
TgeneCDCA7C4310799IMMUNODEFICIENCY-CENTROMERIC INSTABILITY-FACIAL ANOMALIES SYNDROME 31CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneCDCA7C4316788Abnormality of the intestine1GENOMICS_ENGLAND
TgeneCDCA7C4722327PROSTATE CANCER, HEREDITARY, 11CTD_human