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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CADPS2-RPGR (FusionGDB2 ID:12529)

Fusion Gene Summary for CADPS2-RPGR

check button Fusion gene summary
Fusion gene informationFusion gene name: CADPS2-RPGR
Fusion gene ID: 12529
HgeneTgene
Gene symbol

CADPS2

RPGR

Gene ID

93664

6103

Gene namecalcium dependent secretion activator 2retinitis pigmentosa GTPase regulator
SynonymsCAPS2COD1|CORDX1|CRD|PCDX|RP15|RP3|XLRP3|orf15
Cytomap

7q31.32

Xp11.4

Type of geneprotein-codingprotein-coding
Descriptioncalcium-dependent secretion activator 2CAPS-2Ca++-dependent secretion activator 2Ca2+ dependent secretion activator 2Ca2+-dependent activator protein for secretion 2calcium-dependent activator protein for secretion 2X-linked retinitis pigmentosa GTPase regulatorretinitis pigmentosa 15retinitis pigmentosa 3 GTPase regulator
Modification date2020031320200329
UniProtAcc

Q86UW7

.
Ensembl transtripts involved in fusion geneENST00000313070, ENST00000334010, 
ENST00000412584, ENST00000449022, 
ENST00000476131, 		ENST00000318842, 
ENST00000338898, ENST00000339363, 
ENST00000309513, ENST00000342811, 
ENST00000378505, 
Fusion gene scores* DoF score12 X 11 X 7=9244 X 3 X 3=36
# samples 144
** MAII scorelog2(14/924*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CADPS2 [Title/Abstract] AND RPGR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCADPS2(122078395)-RPGR(38150737), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CADPS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RPGR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-Q1-A6DW-01ACADPS2chr7

122078395

-RPGRchrX

38150737

-
ChimerDB4CESCTCGA-Q1-A6DW-01ACADPS2chr7

122078395

-RPGRchrX

38150737

-


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Fusion Gene ORF analysis for CADPS2-RPGR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000313070ENST00000318842CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000313070ENST00000338898CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000313070ENST00000339363CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000313070ENST00000309513CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000313070ENST00000342811CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000313070ENST00000378505CADPS2chr7

122078395

-RPGRchrX

38150737

-
In-frameENST00000334010ENST00000318842CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000334010ENST00000338898CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000334010ENST00000339363CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000334010ENST00000309513CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000334010ENST00000342811CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000334010ENST00000378505CADPS2chr7

122078395

-RPGRchrX

38150737

-
In-frameENST00000412584ENST00000318842CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000412584ENST00000338898CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000412584ENST00000339363CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000412584ENST00000309513CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000412584ENST00000342811CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000412584ENST00000378505CADPS2chr7

122078395

-RPGRchrX

38150737

-
In-frameENST00000449022ENST00000318842CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000449022ENST00000338898CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000449022ENST00000339363CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000449022ENST00000309513CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000449022ENST00000342811CADPS2chr7

122078395

-RPGRchrX

38150737

-
5CDS-intronENST00000449022ENST00000378505CADPS2chr7

122078395

-RPGRchrX

38150737

-
intron-3CDSENST00000476131ENST00000318842CADPS2chr7

122078395

-RPGRchrX

38150737

-
intron-intronENST00000476131ENST00000338898CADPS2chr7

122078395

-RPGRchrX

38150737

-
intron-intronENST00000476131ENST00000339363CADPS2chr7

122078395

-RPGRchrX

38150737

-
intron-intronENST00000476131ENST00000309513CADPS2chr7

122078395

-RPGRchrX

38150737

-
intron-intronENST00000476131ENST00000342811CADPS2chr7

122078395

-RPGRchrX

38150737

-
intron-intronENST00000476131ENST00000378505CADPS2chr7

122078395

-RPGRchrX

38150737

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000313070CADPS2chr7122078395-ENST00000318842RPGRchrX38150737-4386288942239221166
ENST00000334010CADPS2chr7122078395-ENST00000318842RPGRchrX38150737-4398290142239341170
ENST00000412584CADPS2chr7122078395-ENST00000318842RPGRchrX38150737-4085258812136211166
ENST00000449022CADPS2chr7122078395-ENST00000318842RPGRchrX38150737-399324962035291169

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000313070ENST00000318842CADPS2chr7122078395-RPGRchrX38150737-0.0006905510.9993094
ENST00000334010ENST00000318842CADPS2chr7122078395-RPGRchrX38150737-0.0008396580.9991604
ENST00000412584ENST00000318842CADPS2chr7122078395-RPGRchrX38150737-0.0004925790.9995074
ENST00000449022ENST00000318842CADPS2chr7122078395-RPGRchrX38150737-0.0006996240.99930036

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Fusion Genomic Features for CADPS2-RPGR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CADPS2-RPGR


check button Go to

FGviewer for the breakpoints of chr7:122078395-chrX:38150737

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CADPS2

Q86UW7

.
FUNCTION: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCADPS2chr7:122078395chrX:38150737ENST00000412584-1628350_464822.33333333333341256.0DomainC2
HgeneCADPS2chr7:122078395chrX:38150737ENST00000412584-1628487_590822.33333333333341256.0DomainPH
HgeneCADPS2chr7:122078395chrX:38150737ENST00000449022-1730350_464825.33333333333341297.0DomainC2
HgeneCADPS2chr7:122078395chrX:38150737ENST00000449022-1730487_590825.33333333333341297.0DomainPH
TgeneRPGRchr7:122078395chrX:38150737ENST00000309513918530_903409.3333333333333754.0Compositional biasNote=Glu-rich
TgeneRPGRchr7:122078395chrX:38150737ENST000003188421019530_903471.3333333333333816.0Compositional biasNote=Glu-rich
TgeneRPGRchr7:122078395chrX:38150737ENST00000338898018530_9030631.3333333333334Compositional biasNote=Glu-rich
TgeneRPGRchr7:122078395chrX:38150737ENST000003393631018530_903471.33333333333331021.0Compositional biasNote=Glu-rich
TgeneRPGRchr7:122078395chrX:38150737ENST000003428111016530_903471.3333333333333647.0Compositional biasNote=Glu-rich
TgeneRPGRchr7:122078395chrX:38150737ENST000003785051015530_903471.33333333333331153.0Compositional biasNote=Glu-rich
TgeneRPGRchr7:122078395chrX:38150737ENST00000338898018106_1580631.3333333333334RepeatNote=RCC1 2
TgeneRPGRchr7:122078395chrX:38150737ENST00000338898018159_2080631.3333333333334RepeatNote=RCC1 3
TgeneRPGRchr7:122078395chrX:38150737ENST00000338898018209_2610631.3333333333334RepeatNote=RCC1 4
TgeneRPGRchr7:122078395chrX:38150737ENST00000338898018262_3130631.3333333333334RepeatNote=RCC1 5
TgeneRPGRchr7:122078395chrX:38150737ENST00000338898018314_3670631.3333333333334RepeatNote=RCC1 6
TgeneRPGRchr7:122078395chrX:38150737ENST0000033889801854_1050631.3333333333334RepeatNote=RCC1 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCADPS2chr7:122078395chrX:38150737ENST00000412584-1628885_1056822.33333333333341256.0DomainMHD1
HgeneCADPS2chr7:122078395chrX:38150737ENST00000449022-1730885_1056825.33333333333341297.0DomainMHD1
TgeneRPGRchr7:122078395chrX:38150737ENST00000309513918106_158409.3333333333333754.0RepeatNote=RCC1 2
TgeneRPGRchr7:122078395chrX:38150737ENST00000309513918159_208409.3333333333333754.0RepeatNote=RCC1 3
TgeneRPGRchr7:122078395chrX:38150737ENST00000309513918209_261409.3333333333333754.0RepeatNote=RCC1 4
TgeneRPGRchr7:122078395chrX:38150737ENST00000309513918262_313409.3333333333333754.0RepeatNote=RCC1 5
TgeneRPGRchr7:122078395chrX:38150737ENST00000309513918314_367409.3333333333333754.0RepeatNote=RCC1 6
TgeneRPGRchr7:122078395chrX:38150737ENST0000030951391854_105409.3333333333333754.0RepeatNote=RCC1 1
TgeneRPGRchr7:122078395chrX:38150737ENST000003188421019106_158471.3333333333333816.0RepeatNote=RCC1 2
TgeneRPGRchr7:122078395chrX:38150737ENST000003188421019159_208471.3333333333333816.0RepeatNote=RCC1 3
TgeneRPGRchr7:122078395chrX:38150737ENST000003188421019209_261471.3333333333333816.0RepeatNote=RCC1 4
TgeneRPGRchr7:122078395chrX:38150737ENST000003188421019262_313471.3333333333333816.0RepeatNote=RCC1 5
TgeneRPGRchr7:122078395chrX:38150737ENST000003188421019314_367471.3333333333333816.0RepeatNote=RCC1 6
TgeneRPGRchr7:122078395chrX:38150737ENST00000318842101954_105471.3333333333333816.0RepeatNote=RCC1 1
TgeneRPGRchr7:122078395chrX:38150737ENST000003393631018106_158471.33333333333331021.0RepeatNote=RCC1 2
TgeneRPGRchr7:122078395chrX:38150737ENST000003393631018159_208471.33333333333331021.0RepeatNote=RCC1 3
TgeneRPGRchr7:122078395chrX:38150737ENST000003393631018209_261471.33333333333331021.0RepeatNote=RCC1 4
TgeneRPGRchr7:122078395chrX:38150737ENST000003393631018262_313471.33333333333331021.0RepeatNote=RCC1 5
TgeneRPGRchr7:122078395chrX:38150737ENST000003393631018314_367471.33333333333331021.0RepeatNote=RCC1 6
TgeneRPGRchr7:122078395chrX:38150737ENST00000339363101854_105471.33333333333331021.0RepeatNote=RCC1 1
TgeneRPGRchr7:122078395chrX:38150737ENST000003428111016106_158471.3333333333333647.0RepeatNote=RCC1 2
TgeneRPGRchr7:122078395chrX:38150737ENST000003428111016159_208471.3333333333333647.0RepeatNote=RCC1 3
TgeneRPGRchr7:122078395chrX:38150737ENST000003428111016209_261471.3333333333333647.0RepeatNote=RCC1 4
TgeneRPGRchr7:122078395chrX:38150737ENST000003428111016262_313471.3333333333333647.0RepeatNote=RCC1 5
TgeneRPGRchr7:122078395chrX:38150737ENST000003428111016314_367471.3333333333333647.0RepeatNote=RCC1 6
TgeneRPGRchr7:122078395chrX:38150737ENST00000342811101654_105471.3333333333333647.0RepeatNote=RCC1 1
TgeneRPGRchr7:122078395chrX:38150737ENST000003785051015106_158471.33333333333331153.0RepeatNote=RCC1 2
TgeneRPGRchr7:122078395chrX:38150737ENST000003785051015159_208471.33333333333331153.0RepeatNote=RCC1 3
TgeneRPGRchr7:122078395chrX:38150737ENST000003785051015209_261471.33333333333331153.0RepeatNote=RCC1 4
TgeneRPGRchr7:122078395chrX:38150737ENST000003785051015262_313471.33333333333331153.0RepeatNote=RCC1 5
TgeneRPGRchr7:122078395chrX:38150737ENST000003785051015314_367471.33333333333331153.0RepeatNote=RCC1 6
TgeneRPGRchr7:122078395chrX:38150737ENST00000378505101554_105471.33333333333331153.0RepeatNote=RCC1 1


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Fusion Gene Sequence for CADPS2-RPGR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000313070_ENST00000318842_TCGA-Q1-A6DW-01A_CADPS2_chr7_122078395_-_RPGR_chrX_38150737_length(transcript)=4386nt_BP=2889nt
ATTCAATTCCACGTGTTGCTTGTTGTAGGCGCCACAGGTTCCCCACCTGCGTCCGGGCGCTCGGGCGGCTCCGCCTCTGCCGGCGGGCTC
TGGGGAACCGCTGGGTCGGCGCGCCCGGGGCTGGCGGAGCAATTCCTGAGGCGCCCAAGCTCACCCCCAACGCTAACTCCGCCTATTCAG
TCCCGGCGGCTCCCCCTCTCCCCCCTCCCAATCCTCCTCCCGGCTCCTGCCCGCCCCTTTCGCCCTGGTGGTAGGAAACACTCCTGAATC
TAACTCGACGTGTCCGGAAAGCCCTGGCCAGTTTTCCTTTCGTTCTGCGGCCGCTGCAGCCAGCCCCGCGGCTCCCTCAGACCCGCGGGC
GCAGCCGCCGGGGGTGAGGCGCTTGGGGACCGCGGGCCGAGCGGCGGGGATCCCCGAGCACCATGCTGGACCCGTCTTCCAGCGAAGAGG
AGTCGGACGAGGGGCTGGAAGAGGAAAGCCGCGATGTGCTGGTGGCAGCCGGCAGCTCGCAGCGAGCTCCTCCAGCCCCGACTCGGGAAG
GGCGGCGGGACGCGCCGGGGCGCGCGGGCGGCGGCGGCGCGGCCAGATCTGTGAGCCCGAGCCCCTCTGTGCTCAGCGAGGGGCGAGACG
AGCCCCAGCGGCAGCTGGACGATGAGCAGGAGCGGAGGATCCGCCTGCAGCTCTACGTCTTCGTCGTGAGGTGCATCGCGTACCCCTTCA
ACGCCAAGCAGCCCACCGACATGGCCCGGAGGCAGCAGAAGCTTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCC
TCAATGGGGAAACCCAAATTGTAGCTGACGAAGCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGG
CCAGAATGGTACAGAGTGGAGGGTGTTCTGCTAATGACTTCAGAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAG
AAATAGATGGCTTGAGCAAAGAGACAGTGTTGAGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAAC
AGCCAAATAGAATGGCCCTAAGTGCAGTGTCTGAACTTATTCTGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTA
AAAAACTGGAACACCAGCTCCTTTATAATGCATGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCC
GGCTGCAATTGGCAGATAAAATGGCAAAGGAAAGAAAATTCCCCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGC
GGTCTTCAGTGAATTTGCTAATGGCCAATTTGGAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTT
CACAGAACTCTGCATTTTTGGACATAGGAGATGAGAATGAGATTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTG
TCATAATGGAAGTGCAAGGCCTGAAGTCAGTTGCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAG
ACCAGGCCGAAGCCTCAAGGCCACAATGGGGGACTCAAGGAGATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCA
CAGAAAGCACTGGAGTTCTGGCCCTGGAAGATAAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAAT
TACACCGAATGGTAGTTCCAAAAAATAGCCAGGATTCTGACTTAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGC
ATAGTGGATATCTGTATGCCCTTGGACAGAAGGTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCT
TTGCTATGTGCAGTTATAGAGAAAAGAAGTCTGAACCACAAGAATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACC
CAGGCCTTCAGGGTGGTTGTATGTTCTTTAATGCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATAT
TATGGGTTCAAGCCATGTATAGGGCCACAGGTCAATCATATAAACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAA
CTCTCCATGCAGATGCTCAGCTTTATGCAGATCGTTTTCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATC
ATGCCTTCCTTTTTAGAATACTCCAGAGGCAGACTTTGGATCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCC
AAGTCTTTGTGTTAGATGAGTACTGTGCCCGTTATGGTGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATT
CAGAAAATGGTGCTGTCATTGACCCTACCCTGCTCCATTACAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAA
TTGGGACTGTTTCAGTGGAAGAAAAAGAAAGATTTGAGGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCA
GATACTGTTTTCCCTTTGGACGACCTGAAGGTGCTCTAAAAGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTC
CCATACCAGCAGAAGAGGTGAAGAAAGTGGTCAGAAAATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCA
AAATAGAAGATTATTTGCTAGATGAAATGACCAAAGAAGCAGAGATAGATAATTCTTCAACTGTAGAAAGCCTTGGAGAAACTACTGATA
TCTTAAACATGACACACATCATGAGCCTGAATTCCAATGAAAAGTCATTAAAATTATCACCAGTTCAGAAACAAAAGAAACAACAAACAA
TTGGGGAACTGACGCAGGATACAGCTCTTACTGAAAACGATGATAGTGATGAATATGAAGAAATGTCAGAAATGAAAGAAGGGAAAGCAT
GTAAACAACATGTGTCACAAGGGATTTTCATGACGCAGCCAGCTACGACTATCGAAGCATTTTCAGATGAGGAAGTAGAGATCCCAGAGG
AGAAGGAAGGAGCAGAGGATTCAAAAGGAAATGGAATAGAGGAGCAAGAGGTAGAAGCAAATGAGGAAAATGTGAAGGTGCATGGAGGAA
GAAAGGAGAAAACAGAGATCCTATCAGATGACCTTACAGACAAAGCAGAGGATCATGAATTTTCTAAAACTGAGGAACTAAAACTAGAAG
ATGTGGATGAGGAAATTAATGCTGAAAATGTGGAAAGCAAGAAGAAAACTGTGGGAGATGATGAAAGTGTTCCTACAGGTTATCACAGTA
AAACAGAAGGAGCAGAAAGAACCAATGATGATAGCTCAGCTGAAACTATTGAAAAGAAAGAAAAAGCCAACCTAGAGGAACGGGCCATTT
GTGAGTACAATGAAAACCCAAAAGGATACATGCTTGATGATGCAGATAGCAGTTCATTAGAAATCCTAGAAAACAGTGAAACAACACCAA
GCAAAGACATGAAAAAAACAAAGAAGATTTTTCTGTTCAAAAGAGTCCCCTCAATAAATCAAAAGATTGTCAAGAATAACAATGAGCCGC
TCCCAGAGATAAAATCCATAGGAGACCAGATCATTTTAAAAAGTGATAATAAAGATGCCGACCAGAACCACATGAGTCAGAATCATCAGA
ATATCCCACCAACAAATACAGAGAGAAGATCAAAATCCTGTACAATACTATAAATATATATTTATGTTTTCACAGTCACCAAGTGTATTG
TAATGTATACTTGAAAAATGTTATAACTTATGAAGTAAAGTTTCTGATAGTAGTCTTTAAAAGATATAAGACTTAATATGTTTTATTCAG
CTTCTATAAGTGTGACCAGTTTTGATATTTATTTATGCTAATATTTTTAACAAGTCATTTCAAAATATGTGTATCTCAAATTCTCCCTAA
AGTGTTGTGGCCTTAACTGTTCAGTATTGCAATAAAAAATATATTTTTATATGTGGAAAATTGAAATAAGATATTTCCTAGTTTTTACTA
AACAATTTTACTTCTTTATAATTTTATAAGGCAATATTTGCAATCTTACGACACTGTAACAGTTTTTGATGTATTTACAATTTTTACAAA

>In-frame_ENST00000313070_ENST00000318842_TCGA-Q1-A6DW-01A_CADPS2_chr7_122078395_-_RPGR_chrX_38150737_length(amino acids)=1166AA_start in transcript=422_stop in transcript=3922
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVF
VVRCIAYPFNAKQPTDMARRQQKLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFREVFKKN
IEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLDNADEQA
AQIRRELDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEIQLSKSD
VVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELGRVILYP
TSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEG
YTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLYADRFQKHGMDEF
ISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAFCAS
HVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVRKCLEKAALI
NYTRLTEYAKIEDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEE
MSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEDHEF
SKTEELKLEDVDEEINAENVESKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEKANLEERAICEYNENPKGYMLDDADSSSLE

--------------------------------------------------------------
>In-frame_ENST00000334010_ENST00000318842_TCGA-Q1-A6DW-01A_CADPS2_chr7_122078395_-_RPGR_chrX_38150737_length(transcript)=4398nt_BP=2901nt
ATTCAATTCCACGTGTTGCTTGTTGTAGGCGCCACAGGTTCCCCACCTGCGTCCGGGCGCTCGGGCGGCTCCGCCTCTGCCGGCGGGCTC
TGGGGAACCGCTGGGTCGGCGCGCCCGGGGCTGGCGGAGCAATTCCTGAGGCGCCCAAGCTCACCCCCAACGCTAACTCCGCCTATTCAG
TCCCGGCGGCTCCCCCTCTCCCCCCTCCCAATCCTCCTCCCGGCTCCTGCCCGCCCCTTTCGCCCTGGTGGTAGGAAACACTCCTGAATC
TAACTCGACGTGTCCGGAAAGCCCTGGCCAGTTTTCCTTTCGTTCTGCGGCCGCTGCAGCCAGCCCCGCGGCTCCCTCAGACCCGCGGGC
GCAGCCGCCGGGGGTGAGGCGCTTGGGGACCGCGGGCCGAGCGGCGGGGATCCCCGAGCACCATGCTGGACCCGTCTTCCAGCGAAGAGG
AGTCGGACGAGGGGCTGGAAGAGGAAAGCCGCGATGTGCTGGTGGCAGCCGGCAGCTCGCAGCGAGCTCCTCCAGCCCCGACTCGGGAAG
GGCGGCGGGACGCGCCGGGGCGCGCGGGCGGCGGCGGCGCGGCCAGATCTGTGAGCCCGAGCCCCTCTGTGCTCAGCGAGGGGCGAGACG
AGCCCCAGCGGCAGCTGGACGATGAGCAGGAGCGGAGGATCCGCCTGCAGCTCTACGTCTTCGTCGTGAGGTGCATCGCGTACCCCTTCA
ACGCCAAGCAGCCCACCGACATGGCCCGGAGGCAGCAGAAGCTTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCC
TCAATGGGGAAACCCAAATTGTAGCTGACGAAGCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGG
CCAGAATGGTACAGAGTGGAGGGTGTTCTGCTAATGACTTCAGAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAG
AAATAGATGGCTTGAGCAAAGAGACAGTGTTGAGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAAC
AGCCAAATAGAATGGCCCTAAGTGCAGTGTCTGAACTTATTCTGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTA
AAAAACTGGAACACCAGCTCCTTTATAATGCATGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCC
GGCTGCAATTGGCAGATAAAATGGCAAAGGAAAGAAAATTCCCCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGC
GGTCTTCAGTGAATTTGCTAATGGCCAATTTGGAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTT
CACAGAACTCTGCATTTTTGGACATAGGAGATGAGAATGAGATTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTG
TCATAATGGAAGTGCAAGGCCTGAAGTCAGTTGCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAG
ACCAGGCCGAAGCCTCAAGGCCACAATGGGGGACTCAAGGAGATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCA
CAGAAAGCACTGGAGTTCTGGCCCTGGAAGATAAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAAT
TACACCGAATGGTAGTTCCAAAAAATAGCCAGGATTCTGACTTAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGC
ATAGTGGATATCTGTATGCCCTTGGACAGAAGGTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCT
TTGCTATGTGCAGTTATAGAGAAAAGAAGTCTGAACCACAAGAATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACC
CAGGCCTTCAGGGTGGTTGTATGTTCTTTAATGCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATAT
TATGGGTTCAAGCCATGTATAGGGCCACAGGTCAATCATATAAACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAA
CTCTCCATGCAGATGCTCAGCTTTCTGAATTTACAGATGCAGATCGTTTTCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCT
GCAAGCTTGATCATGCCTTCCTTTTTAGAATACTCCAGAGGCAGACTTTGGATCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGT
TTAGCCCTGGCCAAGTCTTTGTGTTAGATGAGTACTGTGCCCGTTATGGTGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAAC
TGATGGAACATTCAGAAAATGGTGCTGTCATTGACCCTACCCTGCTCCATTACAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACA
GGCCTGATGGAATTGGGACTGTTTCAGTGGAAGAAAAAGAAAGATTTGAGGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGA
TAAGCCATTTCAGATACTGTTTTCCCTTTGGACGACCTGAAGGTGCTCTAAAAGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAG
ATATTGCCACTCCCATACCAGCAGAAGAGGTGAAGAAAGTGGTCAGAAAATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCA
CAGAATATGCCAAAATAGAAGATTATTTGCTAGATGAAATGACCAAAGAAGCAGAGATAGATAATTCTTCAACTGTAGAAAGCCTTGGAG
AAACTACTGATATCTTAAACATGACACACATCATGAGCCTGAATTCCAATGAAAAGTCATTAAAATTATCACCAGTTCAGAAACAAAAGA
AACAACAAACAATTGGGGAACTGACGCAGGATACAGCTCTTACTGAAAACGATGATAGTGATGAATATGAAGAAATGTCAGAAATGAAAG
AAGGGAAAGCATGTAAACAACATGTGTCACAAGGGATTTTCATGACGCAGCCAGCTACGACTATCGAAGCATTTTCAGATGAGGAAGTAG
AGATCCCAGAGGAGAAGGAAGGAGCAGAGGATTCAAAAGGAAATGGAATAGAGGAGCAAGAGGTAGAAGCAAATGAGGAAAATGTGAAGG
TGCATGGAGGAAGAAAGGAGAAAACAGAGATCCTATCAGATGACCTTACAGACAAAGCAGAGGATCATGAATTTTCTAAAACTGAGGAAC
TAAAACTAGAAGATGTGGATGAGGAAATTAATGCTGAAAATGTGGAAAGCAAGAAGAAAACTGTGGGAGATGATGAAAGTGTTCCTACAG
GTTATCACAGTAAAACAGAAGGAGCAGAAAGAACCAATGATGATAGCTCAGCTGAAACTATTGAAAAGAAAGAAAAAGCCAACCTAGAGG
AACGGGCCATTTGTGAGTACAATGAAAACCCAAAAGGATACATGCTTGATGATGCAGATAGCAGTTCATTAGAAATCCTAGAAAACAGTG
AAACAACACCAAGCAAAGACATGAAAAAAACAAAGAAGATTTTTCTGTTCAAAAGAGTCCCCTCAATAAATCAAAAGATTGTCAAGAATA
ACAATGAGCCGCTCCCAGAGATAAAATCCATAGGAGACCAGATCATTTTAAAAAGTGATAATAAAGATGCCGACCAGAACCACATGAGTC
AGAATCATCAGAATATCCCACCAACAAATACAGAGAGAAGATCAAAATCCTGTACAATACTATAAATATATATTTATGTTTTCACAGTCA
CCAAGTGTATTGTAATGTATACTTGAAAAATGTTATAACTTATGAAGTAAAGTTTCTGATAGTAGTCTTTAAAAGATATAAGACTTAATA
TGTTTTATTCAGCTTCTATAAGTGTGACCAGTTTTGATATTTATTTATGCTAATATTTTTAACAAGTCATTTCAAAATATGTGTATCTCA
AATTCTCCCTAAAGTGTTGTGGCCTTAACTGTTCAGTATTGCAATAAAAAATATATTTTTATATGTGGAAAATTGAAATAAGATATTTCC
TAGTTTTTACTAAACAATTTTACTTCTTTATAATTTTATAAGGCAATATTTGCAATCTTACGACACTGTAACAGTTTTTGATGTATTTAC

>In-frame_ENST00000334010_ENST00000318842_TCGA-Q1-A6DW-01A_CADPS2_chr7_122078395_-_RPGR_chrX_38150737_length(amino acids)=1170AA_start in transcript=422_stop in transcript=3934
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVF
VVRCIAYPFNAKQPTDMARRQQKLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFREVFKKN
IEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLDNADEQA
AQIRRELDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEIQLSKSD
VVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELGRVILYP
TSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEG
YTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLSEFTDADRFQKHG
MDEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFA
FCASHVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVRKCLEK
AALINYTRLTEYAKIEDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSD
EYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAE
DHEFSKTEELKLEDVDEEINAENVESKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEKANLEERAICEYNENPKGYMLDDADS
SSLEILENSETTPSKDMKKTKKIFLFKRVPSINQKIVKNNNEPLPEIKSIGDQIILKSDNKDADQNHMSQNHQNIPPTNTERRSKSCTIL

--------------------------------------------------------------
>In-frame_ENST00000412584_ENST00000318842_TCGA-Q1-A6DW-01A_CADPS2_chr7_122078395_-_RPGR_chrX_38150737_length(transcript)=4085nt_BP=2588nt
TTTTCCTTTCGTTCTGCGGCCGCTGCAGCCAGCCCCGCGGCTCCCTCAGACCCGCGGGCGCAGCCGCCGGGGGTGAGGCGCTTGGGGACC
GCGGGCCGAGCGGCGGGGATCCCCGAGCACCATGCTGGACCCGTCTTCCAGCGAAGAGGAGTCGGACGAGGGGCTGGAAGAGGAAAGCCG
CGATGTGCTGGTGGCAGCCGGCAGCTCGCAGCGAGCTCCTCCAGCCCCGACTCGGGAAGGGCGGCGGGACGCGCCGGGGCGCGCGGGCGG
CGGCGGCGCGGCCAGATCTGTGAGCCCGAGCCCCTCTGTGCTCAGCGAGGGGCGAGACGAGCCCCAGCGGCAGCTGGACGATGAGCAGGA
GCGGAGGATCCGCCTGCAGCTCTACGTCTTCGTCGTGAGGTGCATCGCGTACCCCTTCAACGCCAAGCAGCCCACCGACATGGCCCGGAG
GCAGCAGAAGCTTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAACCCAAATTGTAGCTGACGA
AGCATTTTGCAACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTACAGAGTGGAGGGTGTTCTGC
TAATGACTTCAGAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCTTGAGCAAAGAGACAGTGTT
GAGCTCATGGATAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAATGGCCCTAAGTGCAGTGTC
TGAACTTATTCTGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAACACCAGCTCCTTTATAATGC
ATGTCAGCTGGATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGGCAGATAAAATGGCAAAGGA
AAGAAAATTCCCCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGAATTTGCTAATGGCCAATTT
GGAAAGTCTTCCAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTGCATTTTTGGACATAGGAGA
TGAGAATGAGATTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAGTGCAAGGCCTGAAGTCAGT
TGCTCCCAATCGAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAGCCTCAAGGCCACAATGGGG
GACTCAAGGAGATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTGGAGTTCTGGCCCTGGAAGA
TAAAGAACTGGGAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGGTAGTTCCAAAAAATAGCCA
GGATTCTGACTTAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATCTGTATGCCCTTGGACAGAA
GGTTTGGAAAAGATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCAGTTATAGAGAAAAGAAGTC
TGAACCACAAGAATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGGGTGGTTGTATGTTCTTTAA
TGCTGTTAAAGAAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAGCCATGTATAGGGCCACAGG
TCAATCATATAAACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAGATGCTCAGCTTTATGCAGA
TCGTTTTCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATCATGCCTTCCTTTTTAGAATACTCCAGAGGCA
GACTTTGGATCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAGTCTTTGTGTTAGATGAGTACTGTGCCCG
TTATGGTGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATTCAGAAAATGGTGCTGTCATTGACCCTACCCT
GCTCCATTACAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTGGGACTGTTTCAGTGGAAGAAAAAGAAAG
ATTTGAGGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCAGATACTGTTTTCCCTTTGGACGACCTGAAGG
TGCTCTAAAAGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCATACCAGCAGAAGAGGTGAAGAAAGTGGT
CAGAAAATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCAAAATAGAAGATTATTTGCTAGATGAAATGAC
CAAAGAAGCAGAGATAGATAATTCTTCAACTGTAGAAAGCCTTGGAGAAACTACTGATATCTTAAACATGACACACATCATGAGCCTGAA
TTCCAATGAAAAGTCATTAAAATTATCACCAGTTCAGAAACAAAAGAAACAACAAACAATTGGGGAACTGACGCAGGATACAGCTCTTAC
TGAAAACGATGATAGTGATGAATATGAAGAAATGTCAGAAATGAAAGAAGGGAAAGCATGTAAACAACATGTGTCACAAGGGATTTTCAT
GACGCAGCCAGCTACGACTATCGAAGCATTTTCAGATGAGGAAGTAGAGATCCCAGAGGAGAAGGAAGGAGCAGAGGATTCAAAAGGAAA
TGGAATAGAGGAGCAAGAGGTAGAAGCAAATGAGGAAAATGTGAAGGTGCATGGAGGAAGAAAGGAGAAAACAGAGATCCTATCAGATGA
CCTTACAGACAAAGCAGAGGATCATGAATTTTCTAAAACTGAGGAACTAAAACTAGAAGATGTGGATGAGGAAATTAATGCTGAAAATGT
GGAAAGCAAGAAGAAAACTGTGGGAGATGATGAAAGTGTTCCTACAGGTTATCACAGTAAAACAGAAGGAGCAGAAAGAACCAATGATGA
TAGCTCAGCTGAAACTATTGAAAAGAAAGAAAAAGCCAACCTAGAGGAACGGGCCATTTGTGAGTACAATGAAAACCCAAAAGGATACAT
GCTTGATGATGCAGATAGCAGTTCATTAGAAATCCTAGAAAACAGTGAAACAACACCAAGCAAAGACATGAAAAAAACAAAGAAGATTTT
TCTGTTCAAAAGAGTCCCCTCAATAAATCAAAAGATTGTCAAGAATAACAATGAGCCGCTCCCAGAGATAAAATCCATAGGAGACCAGAT
CATTTTAAAAAGTGATAATAAAGATGCCGACCAGAACCACATGAGTCAGAATCATCAGAATATCCCACCAACAAATACAGAGAGAAGATC
AAAATCCTGTACAATACTATAAATATATATTTATGTTTTCACAGTCACCAAGTGTATTGTAATGTATACTTGAAAAATGTTATAACTTAT
GAAGTAAAGTTTCTGATAGTAGTCTTTAAAAGATATAAGACTTAATATGTTTTATTCAGCTTCTATAAGTGTGACCAGTTTTGATATTTA
TTTATGCTAATATTTTTAACAAGTCATTTCAAAATATGTGTATCTCAAATTCTCCCTAAAGTGTTGTGGCCTTAACTGTTCAGTATTGCA
ATAAAAAATATATTTTTATATGTGGAAAATTGAAATAAGATATTTCCTAGTTTTTACTAAACAATTTTACTTCTTTATAATTTTATAAGG
CAATATTTGCAATCTTACGACACTGTAACAGTTTTTGATGTATTTACAATTTTTACAAAACTGAGGTAAAATTGTTTATAATGAACATAT

>In-frame_ENST00000412584_ENST00000318842_TCGA-Q1-A6DW-01A_CADPS2_chr7_122078395_-_RPGR_chrX_38150737_length(amino acids)=1166AA_start in transcript=121_stop in transcript=3621
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVF
VVRCIAYPFNAKQPTDMARRQQKLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFREVFKKN
IEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLDNADEQA
AQIRRELDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEIQLSKSD
VVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELGRVILYP
TSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEG
YTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLYADRFQKHGMDEF
ISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAFCAS
HVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVRKCLEKAALI
NYTRLTEYAKIEDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEE
MSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEDHEF
SKTEELKLEDVDEEINAENVESKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEKANLEERAICEYNENPKGYMLDDADSSSLE

--------------------------------------------------------------
>In-frame_ENST00000449022_ENST00000318842_TCGA-Q1-A6DW-01A_CADPS2_chr7_122078395_-_RPGR_chrX_38150737_length(transcript)=3993nt_BP=2496nt
GGCGGGGATCCCCGAGCACCATGCTGGACCCGTCTTCCAGCGAAGAGGAGTCGGACGAGGGGCTGGAAGAGGAAAGCCGCGATGTGCTGG
TGGCAGCCGGCAGCTCGCAGCGAGCTCCTCCAGCCCCGACTCGGGAAGGGCGGCGGGACGCGCCGGGGCGCGCGGGCGGCGGCGGCGCGG
CCAGATCTGTGAGCCCGAGCCCCTCTGTGCTCAGCGAGGGGCGAGACGAGCCCCAGCGGCAGCTGGACGATGAGCAGGAGCGGAGGATCC
GCCTGCAGCTCTACGTCTTCGTCGTGAGGTGCATCGCGTACCCCTTCAACGCCAAGCAGCCCACCGACATGGCCCGGAGGCAGCAGAAGC
TTAACAAACAACAGTTGCAGTTACTGAAAGAACGGTTCCAGGCCTTCCTCAATGGGGAAACCCAAATTGTAGCTGACGAAGCATTTTGCA
ACGCAGTTCGGAGTTATTATGAGGTTTTTCTAAAGAGTGACCGAGTGGCCAGAATGGTACAGAGTGGAGGGTGTTCTGCTAATGACTTCA
GAGAAGTATTTAAGAAAAACATAGAAAAACGTGTGCGGAGTTTGCCAGAAATAGATGGCTTGAGCAAAGAGACAGTGTTGAGCTCATGGA
TAGCCAAATATGATGCCATTTACAGAGGTGAAGAGGACTTGTGCAAACAGCCAAATAGAATGGCCCTAAGTGCAGTGTCTGAACTTATTC
TGAGCAAGGAACAACTCTATGAAATGTTTCAGCAGATTCTGGGTATTAAAAAACTGGAACACCAGCTCCTTTATAATGCATGTCAGCTGG
ATAACGCAGATGAACAAGCAGCCCAGATCAGAAGGGAACTTGATGGCCGGCTGCAATTGGCAGATAAAATGGCAAAGGAAAGAAAATTCC
CCAAATTTATAGCAAAAGATATGGAGAATATGTATATAGAAGAGTTGCGGTCTTCAGTGAATTTGCTAATGGCCAATTTGGAAAGTCTTC
CAGTTTCGAAAGGTGGTCCGGAATTTAAATTACAAAAATTAAAACGTTCACAGAACTCTGCATTTTTGGACATAGGAGATGAGAATGAGA
TTCAGCTGTCAAAGTCCGACGTGGTACTGTCATTCACCTTAGAGATTGTCATAATGGAAGTGCAAGGCCTGAAGTCAGTTGCTCCCAATC
GAATTGTTTACTGTACAATGGAAGTGGAAGGAGAAAAACTTCAGACAGACCAGGCCGAAGCCTCAAGGCCACAATGGGGGACTCAAGGAG
ATTTCACCACCACCCATCCTCGGCCTGTGGTCAAAGTGAAACTCTTCACAGAAAGCACTGGAGTTCTGGCCCTGGAAGATAAAGAACTGG
GAAGGGTGATATTATACCCAACTTCTAATAGCTCCAAATCAGCTGAATTACACCGAATGGTAGTTCCAAAAAATAGCCAGGATTCTGACT
TAAAAATCAAACTGGCAGTGCGAATGGATAAACCAGCACATATGAAGCATAGTGGATATCTGTATGCCCTTGGACAGAAGGTTTGGAAAA
GATGGAAAAAACGTTACTTTGTTCTAGTTCAGGTTAGCCAATATACCTTTGCTATGTGCAGTTATAGAGAAAAGAAGTCTGAACCACAAG
AATTAATGCAGCTTGAAGGCTATACTGTGGATTATACCGATCCCCACCCAGGCCTTCAGGGTGGTTGTATGTTCTTTAATGCTGTTAAAG
AAGGAGATACTGTAATCTTTGCCAGTGATGATGAACAGGACAGAATATTATGGGTTCAAGCCATGTATAGGGCCACAGGTCAATCATATA
AACCAGTTCCTGCAATTCAAACCCAGAAACTGAATCCTAAAGGAGGAACTCTCCATGCAGATGCTCAGCTTTCTGGTAAAGATGCAGATC
GTTTTCAGAAACATGGTATGGATGAGTTTATTTCTGCAAACCCCTGCAAGCTTGATCATGCCTTCCTTTTTAGAATACTCCAGAGGCAGA
CTTTGGATCACAGACTGAATGATTCCTATTCTTGCTTGGGATGGTTTAGCCCTGGCCAAGTCTTTGTGTTAGATGAGTACTGTGCCCGTT
ATGGTGTGAGAGGCTGTCACAGACATCTCTGCTACCTTGCAGAACTGATGGAACATTCAGAAAATGGTGCTGTCATTGACCCTACCCTGC
TCCATTACAGCTTTGCATTCTGTGCCTCTCATGTGCACGGCAACAGGCCTGATGGAATTGGGACTGTTTCAGTGGAAGAAAAAGAAAGAT
TTGAGGAGATAAAAGAGAGACTCTCTTCCCTTTTAGAAAATCAGATAAGCCATTTCAGATACTGTTTTCCCTTTGGACGACCTGAAGGTG
CTCTAAAAGCTACACTTTCATTACTTGAAAGGGTTTTAATGAAAGATATTGCCACTCCCATACCAGCAGAAGAGGTGAAGAAAGTGGTCA
GAAAATGTCTCGAGAAAGCTGCCTTGATCAATTACACTAGACTCACAGAATATGCCAAAATAGAAGATTATTTGCTAGATGAAATGACCA
AAGAAGCAGAGATAGATAATTCTTCAACTGTAGAAAGCCTTGGAGAAACTACTGATATCTTAAACATGACACACATCATGAGCCTGAATT
CCAATGAAAAGTCATTAAAATTATCACCAGTTCAGAAACAAAAGAAACAACAAACAATTGGGGAACTGACGCAGGATACAGCTCTTACTG
AAAACGATGATAGTGATGAATATGAAGAAATGTCAGAAATGAAAGAAGGGAAAGCATGTAAACAACATGTGTCACAAGGGATTTTCATGA
CGCAGCCAGCTACGACTATCGAAGCATTTTCAGATGAGGAAGTAGAGATCCCAGAGGAGAAGGAAGGAGCAGAGGATTCAAAAGGAAATG
GAATAGAGGAGCAAGAGGTAGAAGCAAATGAGGAAAATGTGAAGGTGCATGGAGGAAGAAAGGAGAAAACAGAGATCCTATCAGATGACC
TTACAGACAAAGCAGAGGATCATGAATTTTCTAAAACTGAGGAACTAAAACTAGAAGATGTGGATGAGGAAATTAATGCTGAAAATGTGG
AAAGCAAGAAGAAAACTGTGGGAGATGATGAAAGTGTTCCTACAGGTTATCACAGTAAAACAGAAGGAGCAGAAAGAACCAATGATGATA
GCTCAGCTGAAACTATTGAAAAGAAAGAAAAAGCCAACCTAGAGGAACGGGCCATTTGTGAGTACAATGAAAACCCAAAAGGATACATGC
TTGATGATGCAGATAGCAGTTCATTAGAAATCCTAGAAAACAGTGAAACAACACCAAGCAAAGACATGAAAAAAACAAAGAAGATTTTTC
TGTTCAAAAGAGTCCCCTCAATAAATCAAAAGATTGTCAAGAATAACAATGAGCCGCTCCCAGAGATAAAATCCATAGGAGACCAGATCA
TTTTAAAAAGTGATAATAAAGATGCCGACCAGAACCACATGAGTCAGAATCATCAGAATATCCCACCAACAAATACAGAGAGAAGATCAA
AATCCTGTACAATACTATAAATATATATTTATGTTTTCACAGTCACCAAGTGTATTGTAATGTATACTTGAAAAATGTTATAACTTATGA
AGTAAAGTTTCTGATAGTAGTCTTTAAAAGATATAAGACTTAATATGTTTTATTCAGCTTCTATAAGTGTGACCAGTTTTGATATTTATT
TATGCTAATATTTTTAACAAGTCATTTCAAAATATGTGTATCTCAAATTCTCCCTAAAGTGTTGTGGCCTTAACTGTTCAGTATTGCAAT
AAAAAATATATTTTTATATGTGGAAAATTGAAATAAGATATTTCCTAGTTTTTACTAAACAATTTTACTTCTTTATAATTTTATAAGGCA
ATATTTGCAATCTTACGACACTGTAACAGTTTTTGATGTATTTACAATTTTTACAAAACTGAGGTAAAATTGTTTATAATGAACATATTT

>In-frame_ENST00000449022_ENST00000318842_TCGA-Q1-A6DW-01A_CADPS2_chr7_122078395_-_RPGR_chrX_38150737_length(amino acids)=1169AA_start in transcript=20_stop in transcript=3529
MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPSPSVLSEGRDEPQRQLDDEQERRIRLQLYVF
VVRCIAYPFNAKQPTDMARRQQKLNKQQLQLLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFREVFKKN
IEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLYEMFQQILGIKKLEHQLLYNACQLDNADEQA
AQIRRELDGRLQLADKMAKERKFPKFIAKDMENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEIQLSKSD
VVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHPRPVVKVKLFTESTGVLALEDKELGRVILYP
TSNSSKSAELHRMVVPKNSQDSDLKIKLAVRMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEG
YTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQTQKLNPKGGTLHADAQLSGKDADRFQKHGM
DEFISANPCKLDHAFLFRILQRQTLDHRLNDSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAF
CASHVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLSLLERVLMKDIATPIPAEEVKKVVRKCLEKA
ALINYTRLTEYAKIEDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDE
YEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAED
HEFSKTEELKLEDVDEEINAENVESKKKTVGDDESVPTGYHSKTEGAERTNDDSSAETIEKKEKANLEERAICEYNENPKGYMLDDADSS

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Fusion Gene PPI Analysis for CADPS2-RPGR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCADPS2chr7:122078395chrX:38150737ENST00000412584-1628755_1074822.33333333333341256.0DRD2
HgeneCADPS2chr7:122078395chrX:38150737ENST00000449022-1730755_1074825.33333333333341297.0DRD2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CADPS2-RPGR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCADPS2Q86UW7DB11348Calcium PhosphateAgonistSmall moleculeApproved
HgeneCADPS2Q86UW7DB11348Calcium PhosphateAgonistSmall moleculeApproved
HgeneCADPS2Q86UW7DB11348Calcium PhosphateAgonistSmall moleculeApproved
HgeneCADPS2Q86UW7DB14481Calcium phosphate dihydrateSmall moleculeApproved
HgeneCADPS2Q86UW7DB14481Calcium phosphate dihydrateSmall moleculeApproved
HgeneCADPS2Q86UW7DB14481Calcium phosphate dihydrateSmall moleculeApproved
HgeneCADPS2Q86UW7DB11093Calcium citrateAgonistSmall moleculeApproved|Investigational
HgeneCADPS2Q86UW7DB11093Calcium citrateAgonistSmall moleculeApproved|Investigational
HgeneCADPS2Q86UW7DB11093Calcium citrateAgonistSmall moleculeApproved|Investigational

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Related Diseases for CADPS2-RPGR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCADPS2C0004352Autistic Disorder1CTD_human
HgeneCADPS2C0008370Cholestasis1CTD_human
HgeneCADPS2C0013146Drug abuse1CTD_human
HgeneCADPS2C0013170Drug habituation1CTD_human
HgeneCADPS2C0013222Drug Use Disorders1CTD_human
HgeneCADPS2C0019193Hepatitis, Toxic1CTD_human
HgeneCADPS2C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneCADPS2C0036341Schizophrenia1PSYGENET
HgeneCADPS2C0038580Substance Dependence1CTD_human
HgeneCADPS2C0038586Substance Use Disorders1CTD_human
HgeneCADPS2C0236969Substance-Related Disorders1CTD_human
HgeneCADPS2C0740858Substance abuse problem1CTD_human
HgeneCADPS2C0860207Drug-Induced Liver Disease1CTD_human
HgeneCADPS2C1262760Hepatitis, Drug-Induced1CTD_human
HgeneCADPS2C1510472Drug Dependence1CTD_human
HgeneCADPS2C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneCADPS2C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneCADPS2C4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneCADPS2C4316881Prescription Drug Abuse1CTD_human
TgeneRPGRC1845667RETINITIS PIGMENTOSA 314CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRPGRC2749137Retinitis Pigmentosa, X-Linked, And Sinorespiratory Infections, With Or Without Deafness4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRPGRC0035334Retinitis Pigmentosa3CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRPGRC3489532Cone-Rod Dystrophy 22ORPHANET
TgeneRPGRC0035243Respiratory Tract Infections1CTD_human
TgeneRPGRC0035304Retinal Degeneration1CTD_human
TgeneRPGRC0041912Upper Respiratory Infections1CTD_human
TgeneRPGRC0242383Age related macular degeneration1CTD_human
TgeneRPGRC0854723Retinal Dystrophies1CTD_human
TgeneRPGRC1384666hearing impairment1CTD_human
TgeneRPGRC1844776CONE-ROD DYSTROPHY, X-LINKED, 11CTD_human;GENOMICS_ENGLAND
TgeneRPGRC3151784MACULAR DEGENERATION, X-LINKED ATROPHIC1CTD_human;GENOMICS_ENGLAND