FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CALCB-INSC (FusionGDB2 ID:12541)

Fusion Gene Summary for CALCB-INSC

check button Fusion gene summary
Fusion gene informationFusion gene name: CALCB-INSC
Fusion gene ID: 12541
HgeneTgene
Gene symbol

CALCB

INSC

Gene ID

797

387755

Gene namecalcitonin related polypeptide betaINSC spindle orientation adaptor protein
SynonymsCALC2|CGRP-II|CGRP2-
Cytomap

11p15.2

11p15.2

Type of geneprotein-codingprotein-coding
Descriptioncalcitonin gene-related peptide 2beta-CGRPbeta-type CGRPcalcitonin 2calcitonin gene-related peptide IIprotein inscuteable homologinscuteable homologinscuteable spindle orientation adaptor protein
Modification date2020031320200313
UniProtAcc

P10092

Q1MX18

Ensembl transtripts involved in fusion geneENST00000523376, ENST00000324229, 
ENST00000533448, 		ENST00000379554, 
ENST00000424273, ENST00000379556, 
ENST00000528567, ENST00000525218, 
ENST00000530161, ENST00000447214, 
Fusion gene scores* DoF score3 X 4 X 4=486 X 6 X 8=288
# samples 58
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CALCB [Title/Abstract] AND INSC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCALCB(15099016)-INSC(15197287), # samples:1
CALCB(15102507)-INSC(15170676), # samples:1
CALCB(15099016)-INSC(15170676), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneINSC

GO:0031647

regulation of protein stability

22074847


check buttonFusion gene breakpoints across CALCB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across INSC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-C4-A0EZ-01ACALCBchr11

15099016

+INSCchr11

15197287

+
ChimerDB4COADTCGA-G4-6306-01ACALCBchr11

15102507

+INSCchr11

15170676

+
ChimerDB4UCECTCGA-D1-A3DH-01ACALCBchr11

15099016

+INSCchr11

15170676

+


Top

Fusion Gene ORF analysis for CALCB-INSC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000523376ENST00000379554CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000523376ENST00000424273CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000523376ENST00000379556CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000523376ENST00000528567CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000523376ENST00000525218CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000523376ENST00000530161CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-intronENST00000523376ENST00000447214CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000324229ENST00000379554CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000324229ENST00000424273CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000324229ENST00000379556CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000324229ENST00000528567CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000324229ENST00000525218CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000324229ENST00000530161CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-intronENST00000324229ENST00000447214CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000533448ENST00000379554CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000533448ENST00000424273CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000533448ENST00000379556CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000533448ENST00000528567CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000533448ENST00000525218CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-3CDSENST00000533448ENST00000530161CALCBchr11

15099016

+INSCchr11

15197287

+
3UTR-intronENST00000533448ENST00000447214CALCBchr11

15099016

+INSCchr11

15197287

+
intron-3CDSENST00000523376ENST00000379554CALCBchr11

15102507

+INSCchr11

15170676

+
intron-5UTRENST00000523376ENST00000424273CALCBchr11

15102507

+INSCchr11

15170676

+
intron-5UTRENST00000523376ENST00000379556CALCBchr11

15102507

+INSCchr11

15170676

+
intron-5UTRENST00000523376ENST00000528567CALCBchr11

15102507

+INSCchr11

15170676

+
intron-5UTRENST00000523376ENST00000525218CALCBchr11

15102507

+INSCchr11

15170676

+
intron-5UTRENST00000523376ENST00000530161CALCBchr11

15102507

+INSCchr11

15170676

+
intron-intronENST00000523376ENST00000447214CALCBchr11

15102507

+INSCchr11

15170676

+
intron-3CDSENST00000324229ENST00000379554CALCBchr11

15102507

+INSCchr11

15170676

+
intron-5UTRENST00000324229ENST00000424273CALCBchr11

15102507

+INSCchr11

15170676

+
intron-5UTRENST00000324229ENST00000379556CALCBchr11

15102507

+INSCchr11

15170676

+
intron-5UTRENST00000324229ENST00000528567CALCBchr11

15102507

+INSCchr11

15170676

+
intron-5UTRENST00000324229ENST00000525218CALCBchr11

15102507

+INSCchr11

15170676

+
intron-5UTRENST00000324229ENST00000530161CALCBchr11

15102507

+INSCchr11

15170676

+
intron-intronENST00000324229ENST00000447214CALCBchr11

15102507

+INSCchr11

15170676

+
3UTR-3CDSENST00000533448ENST00000379554CALCBchr11

15102507

+INSCchr11

15170676

+
3UTR-5UTRENST00000533448ENST00000424273CALCBchr11

15102507

+INSCchr11

15170676

+
3UTR-5UTRENST00000533448ENST00000379556CALCBchr11

15102507

+INSCchr11

15170676

+
3UTR-5UTRENST00000533448ENST00000528567CALCBchr11

15102507

+INSCchr11

15170676

+
3UTR-5UTRENST00000533448ENST00000525218CALCBchr11

15102507

+INSCchr11

15170676

+
3UTR-5UTRENST00000533448ENST00000530161CALCBchr11

15102507

+INSCchr11

15170676

+
3UTR-intronENST00000533448ENST00000447214CALCBchr11

15102507

+INSCchr11

15170676

+
3UTR-3CDSENST00000523376ENST00000379554CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000523376ENST00000424273CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000523376ENST00000379556CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000523376ENST00000528567CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000523376ENST00000525218CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000523376ENST00000530161CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-intronENST00000523376ENST00000447214CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-3CDSENST00000324229ENST00000379554CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000324229ENST00000424273CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000324229ENST00000379556CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000324229ENST00000528567CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000324229ENST00000525218CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000324229ENST00000530161CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-intronENST00000324229ENST00000447214CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-3CDSENST00000533448ENST00000379554CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000533448ENST00000424273CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000533448ENST00000379556CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000533448ENST00000528567CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000533448ENST00000525218CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-5UTRENST00000533448ENST00000530161CALCBchr11

15099016

+INSCchr11

15170676

+
3UTR-intronENST00000533448ENST00000447214CALCBchr11

15099016

+INSCchr11

15170676

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for CALCB-INSC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CALCBchr1115099016+INSCchr1115170675+0.000147850.9998522
CALCBchr1115099016+INSCchr1115197286+2.38E-091
CALCBchr1115099016+INSCchr1115170675+0.000147850.9998522
CALCBchr1115099016+INSCchr1115197286+2.38E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CALCB-INSC


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALCB

P10092

INSC

Q1MX18

FUNCTION: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.FUNCTION: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity). {ECO:0000250|UniProtKB:Q3HNM7, ECO:0000305|PubMed:16458856}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for CALCB-INSC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CALCB-INSC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CALCB-INSC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCALCBP10092DB14040EptinezumabAntibodyBiotechApproved|Investigational
HgeneCALCBP10092DB14040EptinezumabAntibodyBiotechApproved|Investigational
HgeneCALCBP10092DB14041FremanezumabAntibodyBiotechApproved|Investigational
HgeneCALCBP10092DB14041FremanezumabAntibodyBiotechApproved|Investigational
HgeneCALCBP10092DB14042GalcanezumabAntibodyBiotechApproved|Investigational
HgeneCALCBP10092DB14042GalcanezumabAntibodyBiotechApproved|Investigational

Top

Related Diseases for CALCB-INSC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource