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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CANX-IL1R2 (FusionGDB2 ID:12841)

Fusion Gene Summary for CANX-IL1R2

check button Fusion gene summary
Fusion gene informationFusion gene name: CANX-IL1R2
Fusion gene ID: 12841
HgeneTgene
Gene symbol

CANX

IL1R2

Gene ID

821

7850

Gene namecalnexininterleukin 1 receptor type 2
SynonymsCNX|IP90|P90CD121b|CDw121b|IL-1R-2|IL-1RT-2|IL-1RT2|IL1R2c|IL1RB
Cytomap

5q35.3

2q11.2

Type of geneprotein-codingprotein-coding
Descriptioncalnexinepididymis secretory sperm binding proteinmajor histocompatibility complex class I antigen-binding protein p88interleukin-1 receptor type 2CD121 antigen-like family member BIL-1 type II receptorIL-1R-betaantigen CDw121binterleukin 1 receptor type II variant 3interleukin-1 receptor betainterleukin-1 receptor type IItype II interleukin-1 receptor, beta
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000504734, ENST00000415618, 
ENST00000452673, ENST00000247461, 
ENST00000512607, ENST00000503126, 
ENST00000332549, ENST00000393414, 
ENST00000441002, ENST00000485335, 
Fusion gene scores* DoF score15 X 16 X 11=26405 X 6 X 6=180
# samples 217
** MAII scorelog2(21/2640*10)=-3.65207669657969
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/180*10)=-1.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CANX [Title/Abstract] AND IL1R2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCANX(179157926)-IL1R2(102638649), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CANX (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IL1R2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-5443-01ACANXchr5

179157926

-IL1R2chr2

102638649

+


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Fusion Gene ORF analysis for CANX-IL1R2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000504734ENST00000332549CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-3CDSENST00000504734ENST00000393414CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-3CDSENST00000504734ENST00000441002CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-intronENST00000504734ENST00000485335CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-3CDSENST00000415618ENST00000332549CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-3CDSENST00000415618ENST00000393414CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-3CDSENST00000415618ENST00000441002CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-intronENST00000415618ENST00000485335CANXchr5

179157926

-IL1R2chr2

102638649

+
In-frameENST00000452673ENST00000332549CANXchr5

179157926

-IL1R2chr2

102638649

+
In-frameENST00000452673ENST00000393414CANXchr5

179157926

-IL1R2chr2

102638649

+
In-frameENST00000452673ENST00000441002CANXchr5

179157926

-IL1R2chr2

102638649

+
5CDS-intronENST00000452673ENST00000485335CANXchr5

179157926

-IL1R2chr2

102638649

+
In-frameENST00000247461ENST00000332549CANXchr5

179157926

-IL1R2chr2

102638649

+
In-frameENST00000247461ENST00000393414CANXchr5

179157926

-IL1R2chr2

102638649

+
In-frameENST00000247461ENST00000441002CANXchr5

179157926

-IL1R2chr2

102638649

+
5CDS-intronENST00000247461ENST00000485335CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-3CDSENST00000512607ENST00000332549CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-3CDSENST00000512607ENST00000393414CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-3CDSENST00000512607ENST00000441002CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-intronENST00000512607ENST00000485335CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-3CDSENST00000503126ENST00000332549CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-3CDSENST00000503126ENST00000393414CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-3CDSENST00000503126ENST00000441002CANXchr5

179157926

-IL1R2chr2

102638649

+
intron-intronENST00000503126ENST00000485335CANXchr5

179157926

-IL1R2chr2

102638649

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000452673CANXchr5179157926-ENST00000332549IL1R2chr2102638649+486842071471925592
ENST00000452673CANXchr5179157926-ENST00000393414IL1R2chr2102638649+474142071471925592
ENST00000452673CANXchr5179157926-ENST00000441002IL1R2chr2102638649+456442071471925592
ENST00000247461CANXchr5179157926-ENST00000332549IL1R2chr2102638649+492142602001978592
ENST00000247461CANXchr5179157926-ENST00000393414IL1R2chr2102638649+479442602001978592
ENST00000247461CANXchr5179157926-ENST00000441002IL1R2chr2102638649+461742602001978592

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000452673ENST00000332549CANXchr5179157926-IL1R2chr2102638649+0.0002265370.99977344
ENST00000452673ENST00000393414CANXchr5179157926-IL1R2chr2102638649+0.0002381950.99976176
ENST00000452673ENST00000441002CANXchr5179157926-IL1R2chr2102638649+0.0002196810.99978036
ENST00000247461ENST00000332549CANXchr5179157926-IL1R2chr2102638649+0.0002242340.9997758
ENST00000247461ENST00000393414CANXchr5179157926-IL1R2chr2102638649+0.0002348610.9997651
ENST00000247461ENST00000441002CANXchr5179157926-IL1R2chr2102638649+0.000217310.99978274

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Fusion Genomic Features for CANX-IL1R2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CANX-IL1R2


check button Go to

FGviewer for the breakpoints of chr5:179157926-chr2:102638649

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-1515276_4091353.3333333333333593.0RegionP domain (Extended arm)
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-1515278_3451353.3333333333333593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-1515348_4051353.3333333333333593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-1515276_4091353.3333333333333593.0RegionP domain (Extended arm)
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-1515278_3451353.3333333333333593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-1515348_4051353.3333333333333593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-1515278_2901353.3333333333333593.0RepeatNote=1-1
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-1515295_3071353.3333333333333593.0RepeatNote=1-2
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-1515314_3261353.3333333333333593.0RepeatNote=1-3
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-1515333_3451353.3333333333333593.0RepeatNote=1-4
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-1515348_3581353.3333333333333593.0RepeatNote=2-1
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-1515367_3771353.3333333333333593.0RepeatNote=2-2
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-1515381_3911353.3333333333333593.0RepeatNote=2-3
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-1515395_4051353.3333333333333593.0RepeatNote=2-4
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-1515278_2901353.3333333333333593.0RepeatNote=1-1
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-1515295_3071353.3333333333333593.0RepeatNote=1-2
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-1515314_3261353.3333333333333593.0RepeatNote=1-3
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-1515333_3451353.3333333333333593.0RepeatNote=1-4
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-1515348_3581353.3333333333333593.0RepeatNote=2-1
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-1515367_3771353.3333333333333593.0RepeatNote=2-2
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-1515381_3911353.3333333333333593.0RepeatNote=2-3
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-1515395_4051353.3333333333333593.0RepeatNote=2-4
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-151521_4811353.3333333333333593.0Topological domainLumenal
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-151521_4811353.3333333333333593.0Topological domainLumenal
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-1515482_5021353.3333333333333593.0TransmembraneHelical
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-1515482_5021353.3333333333333593.0TransmembraneHelical
TgeneIL1R2chr5:179157926chr2:102638649ENST0000033254949237_349229.33333333333334399.0DomainNote=Ig-like C2-type 3
TgeneIL1R2chr5:179157926chr2:102638649ENST0000039341449237_349229.33333333333334399.0DomainNote=Ig-like C2-type 3
TgeneIL1R2chr5:179157926chr2:102638649ENST0000044100236237_349229.33333333333334297.0DomainNote=Ig-like C2-type 3
TgeneIL1R2chr5:179157926chr2:102638649ENST0000033254949329_343229.33333333333334399.0RegionContains proteolytic cleavage site
TgeneIL1R2chr5:179157926chr2:102638649ENST0000039341449329_343229.33333333333334399.0RegionContains proteolytic cleavage site
TgeneIL1R2chr5:179157926chr2:102638649ENST0000044100236329_343229.33333333333334297.0RegionContains proteolytic cleavage site
TgeneIL1R2chr5:179157926chr2:102638649ENST0000033254949370_398229.33333333333334399.0Topological domainCytoplasmic
TgeneIL1R2chr5:179157926chr2:102638649ENST0000039341449370_398229.33333333333334399.0Topological domainCytoplasmic
TgeneIL1R2chr5:179157926chr2:102638649ENST0000044100236370_398229.33333333333334297.0Topological domainCytoplasmic
TgeneIL1R2chr5:179157926chr2:102638649ENST0000033254949344_369229.33333333333334399.0TransmembraneHelical
TgeneIL1R2chr5:179157926chr2:102638649ENST0000039341449344_369229.33333333333334399.0TransmembraneHelical
TgeneIL1R2chr5:179157926chr2:102638649ENST0000044100236344_369229.33333333333334297.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-115276_4090593.0RegionP domain (Extended arm)
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-115278_3450593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-115348_4050593.0RegionNote=4 X approximate repeats
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-115278_2900593.0RepeatNote=1-1
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-115295_3070593.0RepeatNote=1-2
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-115314_3260593.0RepeatNote=1-3
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-115333_3450593.0RepeatNote=1-4
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-115348_3580593.0RepeatNote=2-1
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-115367_3770593.0RepeatNote=2-2
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-115381_3910593.0RepeatNote=2-3
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-115395_4050593.0RepeatNote=2-4
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-11521_4810593.0Topological domainLumenal
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-115482_5020593.0TransmembraneHelical
TgeneIL1R2chr5:179157926chr2:102638649ENST0000033254949134_223229.33333333333334399.0DomainNote=Ig-like C2-type 2
TgeneIL1R2chr5:179157926chr2:102638649ENST000003325494918_124229.33333333333334399.0DomainNote=Ig-like C2-type 1
TgeneIL1R2chr5:179157926chr2:102638649ENST0000039341449134_223229.33333333333334399.0DomainNote=Ig-like C2-type 2
TgeneIL1R2chr5:179157926chr2:102638649ENST000003934144918_124229.33333333333334399.0DomainNote=Ig-like C2-type 1
TgeneIL1R2chr5:179157926chr2:102638649ENST0000044100236134_223229.33333333333334297.0DomainNote=Ig-like C2-type 2
TgeneIL1R2chr5:179157926chr2:102638649ENST000004410023618_124229.33333333333334297.0DomainNote=Ig-like C2-type 1
TgeneIL1R2chr5:179157926chr2:102638649ENST000003325494914_343229.33333333333334399.0Topological domainExtracellular
TgeneIL1R2chr5:179157926chr2:102638649ENST000003934144914_343229.33333333333334399.0Topological domainExtracellular
TgeneIL1R2chr5:179157926chr2:102638649ENST000004410023614_343229.33333333333334297.0Topological domainExtracellular


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Fusion Gene Sequence for CANX-IL1R2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000452673_ENST00000332549_TCGA-CV-5443-01A_CANX_chr5_179157926_-_IL1R2_chr2_102638649_length(transcript)=4868nt_BP=4207nt
ACTCAGGGGCCAGGGGCGGGCACAGGGCCGGGCTTCGTGCGGTGGGGCTCGCTCGCGCGGCAGCGGTGGCCGAGGCCTCTTGGTTCTGCG
GCACGTGACGGTCGGGCCGCCTCCGCCTCTCTCTTTACTGCGGCGCGGGGCAAGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTG
GTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGACATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAG
GTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTTCATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTT
GCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGATTTTATCCAAAGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGAT
GGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGCTTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATC
TCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCAAGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGT
GGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAACTCAACCTGGATCAGTTCCATGACAAGACCCCTTATACGATTATGTTTGGTCCA
GATAAATGTGGAGAGGACTATAAACTGCACTTCATCTTCCGACACAAAAACCCCAAAACGGGTATCTATGAAGAAAAACATGCTAAGAGG
CCAGATGCAGATCTGAAGACCTATTTTACTGATAAGAAAACACATCTTTACACACTAATCTTGAATCCAGATAATAGTTTTGAAATACTG
GTTGACCAATCTGTGGTGAATAGTGGAAATCTGCTCAATGACATGACTCCTCCTGTAAATCCTTCACGTGAAATTGAGGACCCAGAAGAC
CGGAAGCCCGAGGATTGGGATGAAAGACCAAAAATCCCAGATCCAGAAGCTGTCAAGCCAGATGACTGGGATGAAGATGCCCCTGCTAAG
ATTCCAGATGAAGAGGCCACAAAACCCGAAGGCTGGTTAGATGATGAGCCTGAGTACGTACCTGATCCAGACGCAGAGAAACCTGAGGAT
TGGGATGAAGACATGGATGGAGAATGGGAGGCTCCTCAGATTGCCAACCCTAGATGTGAGTCAGCTCCTGGATGTGGTGTCTGGCAGCGA
CCTGTGATTGACAACCCCAATTATAAAGGCAAATGGAAGCCTCCTATGATTGACAATCCCAGTTACCAGGGAATCTGGAAACCCAGGAAA
ATACCAAATCCAGATTTCTTTGAAGATCTGGAACCTTTCAGAATGACTCCTTTTAGTGCTATTGGTTTGGAGCTGTGGTCCATGACCTCT
GACATTTTTTTTGACAACTTTATCATTTGTGCTGATCGAAGAATAGTTGATGATTGGGCCAATGATGGATGGGGCCTGAAGAAAGCTGCT
GATGGGGCTGCTGAGCCAGGCGTTGTGGGGCAGATGATCGAGGCAGCTGAAGAGCGCCCGTGGCTGTGGGTAGTCTATATTCTAACTGTA
GCCCTTCCTGTGTTCCTGGTTATCCTCTTCTGCTGTTCTGGAAAGAAACAGACCAGTGGTATGGAGTATAAGAAAACTGATGCACCTCAA
CCGGATGTGAAGGAAGAGGAAGAAGAGAAGGAAGAGGAAAAGGACAAGGGAGATGAGGAGGAGGAAGGAGAAGAGAAACTTGAAGAGAAA
CAGAAAAGTGATGCTGAAGAAGATGGTGGCACTGTCAGTCAAGAGGAGGAAGACAGAAAACCTAAAGCAGAGGAGGATGAAATTTTGAAC
AGATCACCAAGAAACAGAAAGCCACGAAGAGAGTGAAACAATCTTAAGAGCTTGATCTGTGATTTCTTCTCCCTCCTCCCCTGCAAGAGT
GGTCCTAGGAGAGGACCTGGCACACCTTAGGTTGACATTCAGAAAACTTCAAGACATCACCATCAGCAGGCTCCAGTTGAACACTAGTCT
GTGTAACTTTAAACATCTAGCAGTAAATACTTGCAGTTGTGATATAAAGGACCCTGTTTCTGTAGAAAAGAAAACATTTAACATAATGGT
TGTGAAATGTAACATGAAGCAAACTAACTTTTTTTTTTTTAACATCTTTGTTTTTAAAATAGAATGATAGAACTTTGCCAGTCTTTAAGA
TCTTGGCTTAATTTAATGTATTAATCTGTTTGTGCAAACATAATACCACCATTTAAAAATGTTAGGGAGATGAGTTGCAGTTTTTATAAT
AGATTTTTTTTAAAGTTTGGTATTGTAAAACATTCACACCTCTGTCCCTCAAAATTGATAATTACGTTTAAAGTGCAGTCATTTGTGGTT
AGAATCTTGTTTTGTTTGCTTCCATTATTGAGTTCCTCCTAAGGAAATTGAGGAGAGGGACTGAATAGAAGCCCAAATTCATATAAAAGT
TGCGTTTAAGTTGTATTAAAAATAGATATATAAGAAAAAATTCTTTCACTTGATGTTTGTTAGACCAGAAAGTGTGTGTGTTCTGTAGCT
CAGTTCCCAGACAGCTTTTTAGGTAGTGGAGGAGGTGGCTTCATGTGGCACTTGGGCATTTATATTCCACTTGGGAGGGTCAGGCTGTGG
CCTTCTGGAGCAGGTGGCTTGTTAAGGAATGCTAGCAGGGCATGGCACGTGAGCTCCGGAATAGATGTCTTCATCACTTCTTCCACTGTG
TGTTGACACTGTTTTCCTTACCTATTTCCTCAGATCCCCAGCTTTCTCCTCTGCTATGCATTTTCTTCACAGTGCAGCTTGCAGTCCGTT
GCTGAAAATGATTATAAGCCCTGCATAATGTTAAGCTTTATTGTGATTACGTGTATGTTTCTTCTTTCTTTTAAGCAGACCCATACCTTT
CCAGGGTCAAAGTACAGAATAGAATACATTGATACAAAGTACAGAAAAATACTTTGATTTTTATCCATTTCTTTTACTCTGTGTAAAGAC
TTGAGAAGTCTAATTCACAGGCAAACCAATACAGAATTGACTGCAGTTGAACAGACTAGAAGTATTTGTGGGAGGAGTGACATGAAGCAT
GAGTTATCTGATTTTTTTTGTAGCTGCTATATATTTTAAGCCTTCATTTGCAATTCATGTAACAGTTGTGTCATAAATTACACAATAAAG
CAGTCCTGTTCAAATTTTTTTTTAACGTGGCTTGTAGAATTTTTAAAAAAGTGATCTTAGGTTTGTTTTTTCATGCGGGATGCAGATGGG
TGCTATCAGAGCCTCTCCCACACCACTATAGTGTAATAATGTTATTATTACTCTACACTGAAACGTATTCAGAGTTAGATATTATTTTAG
CTTCAGTTGTTCTTTAGAGGCTTTCAAATGTACCGATGATACTGTTTCTTGCACTGAATATATAAACACTCCACAGTGTTTATATTGGGA
AGATATTGGGAAGGAAATATATTTGTAAAAGATGAAGGCTGTATCTATTTTTTTTTCTTTTTAAAGTTTGTTCACTTAAATTCTTTTGAG
GATGGGATGTATTTTTCTTGCTGTTCAGTGCTTTTTCCTTTTCATCTGTTGTTCTGTGGTCACAGTGACCTTAGCTACATAGCAGACTTT
CCCAAATGTATTGATTACAAATAAACAGTTGTTACTTAGCAAGACCTGAAAATATGTCTGCAGGTTTCTCCTTGAAGCAAATGTGTGGGA
TCATTGCATTTCCAGAAATCTGCCTCCTTCACCCTCCGTTGACAGTATATGTCATGCCTCACTTTCTTCTAGCTGAGCTTTAAATCATTA
GAGCTTAAATTGTCAGATCGTTCATTGCCTTTCCAGGGTTATTTAGTAAAGTTTGTTGAAAACAAAAACGCCTTTTCTTGGTTCTTTTTT
CAGTTATTTTGAAGGTCCAGCATCCTGATTAAATGTCTGACACATTAATGAATGACCAGCAGCAGCTTTCAGCTCTTAAAAAGACACTTA
TATTTTGATTTTACATGCTGGTTACCTGTTCCATTGTTGTCAAATGCCCACTCTCCATCAGATGTGTTCCTCCATTTTCTTATCCACAAA
GTACTCCTCACTTTTCAATTTGTCATGTTACTAAATGGTGTTACATTAAAGCCCTGTGTTAAGTGTCAAAAAAAAGAAGAGACCATTCCT
GTGATCATTTCCCCCCTCAAGACCATATCAGCTTCTCTGGGGTCAAGACTGACAATCCCGTGTAAGGTGTTTCTGGGAACCGGCACACCC
TTAACCACCATGCTGTGGTGGACGGCCAATGACACCCACATAGAGAGCGCCTACCCGGGAGGCCGCGTGACCGAGGGGCCACGCCAGGAA
TATTCAGAAAATAATGAGAACTACATTGAAGTGCCATTGATTTTTGATCCTGTCACAAGAGAGGATTTGCACATGGATTTTAAATGTGTT
GTCCATAATACCCTGAGTTTTCAGACACTACGCACCACAGTCAAGGAAGCCTCCTCCACGTTCTCCTGGGGCATTGTGCTGGCCCCACTT
TCACTGGCCTTCTTGGTTTTGGGGGGAATATGGATGCACAGACGGTGCAAACACAGAACTGGAAAAGCAGATGGTCTGACTGTGCTATGG
CCTCATCATCAAGACTTTCAATCCTATCCCAAGTGAAATAAATGGAATGAAATAATTCAAACACAAACTCCGTACGTCTTCTCTTATGGA
AGTGGCTGTGTCTTTTTGAGGGACTCTGTTCTTTGCCTCAGTTGTCTACCAAAGGTGCCACATTTATAGTGGCTTTGTAGTAAAGGACTA

>In-frame_ENST00000452673_ENST00000332549_TCGA-CV-5443-01A_CANX_chr5_179157926_-_IL1R2_chr2_102638649_length(amino acids)=592AA_start in transcript=147_stop in transcript=1925
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKK
DDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFH
DKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPV
NPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRC
ESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDW
ANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDE

--------------------------------------------------------------
>In-frame_ENST00000452673_ENST00000393414_TCGA-CV-5443-01A_CANX_chr5_179157926_-_IL1R2_chr2_102638649_length(transcript)=4741nt_BP=4207nt
ACTCAGGGGCCAGGGGCGGGCACAGGGCCGGGCTTCGTGCGGTGGGGCTCGCTCGCGCGGCAGCGGTGGCCGAGGCCTCTTGGTTCTGCG
GCACGTGACGGTCGGGCCGCCTCCGCCTCTCTCTTTACTGCGGCGCGGGGCAAGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTG
GTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGACATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAG
GTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTTCATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTT
GCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGATTTTATCCAAAGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGAT
GGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGCTTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATC
TCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCAAGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGT
GGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAACTCAACCTGGATCAGTTCCATGACAAGACCCCTTATACGATTATGTTTGGTCCA
GATAAATGTGGAGAGGACTATAAACTGCACTTCATCTTCCGACACAAAAACCCCAAAACGGGTATCTATGAAGAAAAACATGCTAAGAGG
CCAGATGCAGATCTGAAGACCTATTTTACTGATAAGAAAACACATCTTTACACACTAATCTTGAATCCAGATAATAGTTTTGAAATACTG
GTTGACCAATCTGTGGTGAATAGTGGAAATCTGCTCAATGACATGACTCCTCCTGTAAATCCTTCACGTGAAATTGAGGACCCAGAAGAC
CGGAAGCCCGAGGATTGGGATGAAAGACCAAAAATCCCAGATCCAGAAGCTGTCAAGCCAGATGACTGGGATGAAGATGCCCCTGCTAAG
ATTCCAGATGAAGAGGCCACAAAACCCGAAGGCTGGTTAGATGATGAGCCTGAGTACGTACCTGATCCAGACGCAGAGAAACCTGAGGAT
TGGGATGAAGACATGGATGGAGAATGGGAGGCTCCTCAGATTGCCAACCCTAGATGTGAGTCAGCTCCTGGATGTGGTGTCTGGCAGCGA
CCTGTGATTGACAACCCCAATTATAAAGGCAAATGGAAGCCTCCTATGATTGACAATCCCAGTTACCAGGGAATCTGGAAACCCAGGAAA
ATACCAAATCCAGATTTCTTTGAAGATCTGGAACCTTTCAGAATGACTCCTTTTAGTGCTATTGGTTTGGAGCTGTGGTCCATGACCTCT
GACATTTTTTTTGACAACTTTATCATTTGTGCTGATCGAAGAATAGTTGATGATTGGGCCAATGATGGATGGGGCCTGAAGAAAGCTGCT
GATGGGGCTGCTGAGCCAGGCGTTGTGGGGCAGATGATCGAGGCAGCTGAAGAGCGCCCGTGGCTGTGGGTAGTCTATATTCTAACTGTA
GCCCTTCCTGTGTTCCTGGTTATCCTCTTCTGCTGTTCTGGAAAGAAACAGACCAGTGGTATGGAGTATAAGAAAACTGATGCACCTCAA
CCGGATGTGAAGGAAGAGGAAGAAGAGAAGGAAGAGGAAAAGGACAAGGGAGATGAGGAGGAGGAAGGAGAAGAGAAACTTGAAGAGAAA
CAGAAAAGTGATGCTGAAGAAGATGGTGGCACTGTCAGTCAAGAGGAGGAAGACAGAAAACCTAAAGCAGAGGAGGATGAAATTTTGAAC
AGATCACCAAGAAACAGAAAGCCACGAAGAGAGTGAAACAATCTTAAGAGCTTGATCTGTGATTTCTTCTCCCTCCTCCCCTGCAAGAGT
GGTCCTAGGAGAGGACCTGGCACACCTTAGGTTGACATTCAGAAAACTTCAAGACATCACCATCAGCAGGCTCCAGTTGAACACTAGTCT
GTGTAACTTTAAACATCTAGCAGTAAATACTTGCAGTTGTGATATAAAGGACCCTGTTTCTGTAGAAAAGAAAACATTTAACATAATGGT
TGTGAAATGTAACATGAAGCAAACTAACTTTTTTTTTTTTAACATCTTTGTTTTTAAAATAGAATGATAGAACTTTGCCAGTCTTTAAGA
TCTTGGCTTAATTTAATGTATTAATCTGTTTGTGCAAACATAATACCACCATTTAAAAATGTTAGGGAGATGAGTTGCAGTTTTTATAAT
AGATTTTTTTTAAAGTTTGGTATTGTAAAACATTCACACCTCTGTCCCTCAAAATTGATAATTACGTTTAAAGTGCAGTCATTTGTGGTT
AGAATCTTGTTTTGTTTGCTTCCATTATTGAGTTCCTCCTAAGGAAATTGAGGAGAGGGACTGAATAGAAGCCCAAATTCATATAAAAGT
TGCGTTTAAGTTGTATTAAAAATAGATATATAAGAAAAAATTCTTTCACTTGATGTTTGTTAGACCAGAAAGTGTGTGTGTTCTGTAGCT
CAGTTCCCAGACAGCTTTTTAGGTAGTGGAGGAGGTGGCTTCATGTGGCACTTGGGCATTTATATTCCACTTGGGAGGGTCAGGCTGTGG
CCTTCTGGAGCAGGTGGCTTGTTAAGGAATGCTAGCAGGGCATGGCACGTGAGCTCCGGAATAGATGTCTTCATCACTTCTTCCACTGTG
TGTTGACACTGTTTTCCTTACCTATTTCCTCAGATCCCCAGCTTTCTCCTCTGCTATGCATTTTCTTCACAGTGCAGCTTGCAGTCCGTT
GCTGAAAATGATTATAAGCCCTGCATAATGTTAAGCTTTATTGTGATTACGTGTATGTTTCTTCTTTCTTTTAAGCAGACCCATACCTTT
CCAGGGTCAAAGTACAGAATAGAATACATTGATACAAAGTACAGAAAAATACTTTGATTTTTATCCATTTCTTTTACTCTGTGTAAAGAC
TTGAGAAGTCTAATTCACAGGCAAACCAATACAGAATTGACTGCAGTTGAACAGACTAGAAGTATTTGTGGGAGGAGTGACATGAAGCAT
GAGTTATCTGATTTTTTTTGTAGCTGCTATATATTTTAAGCCTTCATTTGCAATTCATGTAACAGTTGTGTCATAAATTACACAATAAAG
CAGTCCTGTTCAAATTTTTTTTTAACGTGGCTTGTAGAATTTTTAAAAAAGTGATCTTAGGTTTGTTTTTTCATGCGGGATGCAGATGGG
TGCTATCAGAGCCTCTCCCACACCACTATAGTGTAATAATGTTATTATTACTCTACACTGAAACGTATTCAGAGTTAGATATTATTTTAG
CTTCAGTTGTTCTTTAGAGGCTTTCAAATGTACCGATGATACTGTTTCTTGCACTGAATATATAAACACTCCACAGTGTTTATATTGGGA
AGATATTGGGAAGGAAATATATTTGTAAAAGATGAAGGCTGTATCTATTTTTTTTTCTTTTTAAAGTTTGTTCACTTAAATTCTTTTGAG
GATGGGATGTATTTTTCTTGCTGTTCAGTGCTTTTTCCTTTTCATCTGTTGTTCTGTGGTCACAGTGACCTTAGCTACATAGCAGACTTT
CCCAAATGTATTGATTACAAATAAACAGTTGTTACTTAGCAAGACCTGAAAATATGTCTGCAGGTTTCTCCTTGAAGCAAATGTGTGGGA
TCATTGCATTTCCAGAAATCTGCCTCCTTCACCCTCCGTTGACAGTATATGTCATGCCTCACTTTCTTCTAGCTGAGCTTTAAATCATTA
GAGCTTAAATTGTCAGATCGTTCATTGCCTTTCCAGGGTTATTTAGTAAAGTTTGTTGAAAACAAAAACGCCTTTTCTTGGTTCTTTTTT
CAGTTATTTTGAAGGTCCAGCATCCTGATTAAATGTCTGACACATTAATGAATGACCAGCAGCAGCTTTCAGCTCTTAAAAAGACACTTA
TATTTTGATTTTACATGCTGGTTACCTGTTCCATTGTTGTCAAATGCCCACTCTCCATCAGATGTGTTCCTCCATTTTCTTATCCACAAA
GTACTCCTCACTTTTCAATTTGTCATGTTACTAAATGGTGTTACATTAAAGCCCTGTGTTAAGTGTCAAAAAAAAGAAGAGACCATTCCT
GTGATCATTTCCCCCCTCAAGACCATATCAGCTTCTCTGGGGTCAAGACTGACAATCCCGTGTAAGGTGTTTCTGGGAACCGGCACACCC
TTAACCACCATGCTGTGGTGGACGGCCAATGACACCCACATAGAGAGCGCCTACCCGGGAGGCCGCGTGACCGAGGGGCCACGCCAGGAA
TATTCAGAAAATAATGAGAACTACATTGAAGTGCCATTGATTTTTGATCCTGTCACAAGAGAGGATTTGCACATGGATTTTAAATGTGTT
GTCCATAATACCCTGAGTTTTCAGACACTACGCACCACAGTCAAGGAAGCCTCCTCCACGTTCTCCTGGGGCATTGTGCTGGCCCCACTT
TCACTGGCCTTCTTGGTTTTGGGGGGAATATGGATGCACAGACGGTGCAAACACAGAACTGGAAAAGCAGATGGTCTGACTGTGCTATGG

>In-frame_ENST00000452673_ENST00000393414_TCGA-CV-5443-01A_CANX_chr5_179157926_-_IL1R2_chr2_102638649_length(amino acids)=592AA_start in transcript=147_stop in transcript=1925
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKK
DDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFH
DKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPV
NPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRC
ESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDW
ANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDE

--------------------------------------------------------------
>In-frame_ENST00000452673_ENST00000441002_TCGA-CV-5443-01A_CANX_chr5_179157926_-_IL1R2_chr2_102638649_length(transcript)=4564nt_BP=4207nt
ACTCAGGGGCCAGGGGCGGGCACAGGGCCGGGCTTCGTGCGGTGGGGCTCGCTCGCGCGGCAGCGGTGGCCGAGGCCTCTTGGTTCTGCG
GCACGTGACGGTCGGGCCGCCTCCGCCTCTCTCTTTACTGCGGCGCGGGGCAAGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTG
GTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGACATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAG
GTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTTCATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTT
GCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGATTTTATCCAAAGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGAT
GGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGCTTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATC
TCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCAAGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGT
GGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAACTCAACCTGGATCAGTTCCATGACAAGACCCCTTATACGATTATGTTTGGTCCA
GATAAATGTGGAGAGGACTATAAACTGCACTTCATCTTCCGACACAAAAACCCCAAAACGGGTATCTATGAAGAAAAACATGCTAAGAGG
CCAGATGCAGATCTGAAGACCTATTTTACTGATAAGAAAACACATCTTTACACACTAATCTTGAATCCAGATAATAGTTTTGAAATACTG
GTTGACCAATCTGTGGTGAATAGTGGAAATCTGCTCAATGACATGACTCCTCCTGTAAATCCTTCACGTGAAATTGAGGACCCAGAAGAC
CGGAAGCCCGAGGATTGGGATGAAAGACCAAAAATCCCAGATCCAGAAGCTGTCAAGCCAGATGACTGGGATGAAGATGCCCCTGCTAAG
ATTCCAGATGAAGAGGCCACAAAACCCGAAGGCTGGTTAGATGATGAGCCTGAGTACGTACCTGATCCAGACGCAGAGAAACCTGAGGAT
TGGGATGAAGACATGGATGGAGAATGGGAGGCTCCTCAGATTGCCAACCCTAGATGTGAGTCAGCTCCTGGATGTGGTGTCTGGCAGCGA
CCTGTGATTGACAACCCCAATTATAAAGGCAAATGGAAGCCTCCTATGATTGACAATCCCAGTTACCAGGGAATCTGGAAACCCAGGAAA
ATACCAAATCCAGATTTCTTTGAAGATCTGGAACCTTTCAGAATGACTCCTTTTAGTGCTATTGGTTTGGAGCTGTGGTCCATGACCTCT
GACATTTTTTTTGACAACTTTATCATTTGTGCTGATCGAAGAATAGTTGATGATTGGGCCAATGATGGATGGGGCCTGAAGAAAGCTGCT
GATGGGGCTGCTGAGCCAGGCGTTGTGGGGCAGATGATCGAGGCAGCTGAAGAGCGCCCGTGGCTGTGGGTAGTCTATATTCTAACTGTA
GCCCTTCCTGTGTTCCTGGTTATCCTCTTCTGCTGTTCTGGAAAGAAACAGACCAGTGGTATGGAGTATAAGAAAACTGATGCACCTCAA
CCGGATGTGAAGGAAGAGGAAGAAGAGAAGGAAGAGGAAAAGGACAAGGGAGATGAGGAGGAGGAAGGAGAAGAGAAACTTGAAGAGAAA
CAGAAAAGTGATGCTGAAGAAGATGGTGGCACTGTCAGTCAAGAGGAGGAAGACAGAAAACCTAAAGCAGAGGAGGATGAAATTTTGAAC
AGATCACCAAGAAACAGAAAGCCACGAAGAGAGTGAAACAATCTTAAGAGCTTGATCTGTGATTTCTTCTCCCTCCTCCCCTGCAAGAGT
GGTCCTAGGAGAGGACCTGGCACACCTTAGGTTGACATTCAGAAAACTTCAAGACATCACCATCAGCAGGCTCCAGTTGAACACTAGTCT
GTGTAACTTTAAACATCTAGCAGTAAATACTTGCAGTTGTGATATAAAGGACCCTGTTTCTGTAGAAAAGAAAACATTTAACATAATGGT
TGTGAAATGTAACATGAAGCAAACTAACTTTTTTTTTTTTAACATCTTTGTTTTTAAAATAGAATGATAGAACTTTGCCAGTCTTTAAGA
TCTTGGCTTAATTTAATGTATTAATCTGTTTGTGCAAACATAATACCACCATTTAAAAATGTTAGGGAGATGAGTTGCAGTTTTTATAAT
AGATTTTTTTTAAAGTTTGGTATTGTAAAACATTCACACCTCTGTCCCTCAAAATTGATAATTACGTTTAAAGTGCAGTCATTTGTGGTT
AGAATCTTGTTTTGTTTGCTTCCATTATTGAGTTCCTCCTAAGGAAATTGAGGAGAGGGACTGAATAGAAGCCCAAATTCATATAAAAGT
TGCGTTTAAGTTGTATTAAAAATAGATATATAAGAAAAAATTCTTTCACTTGATGTTTGTTAGACCAGAAAGTGTGTGTGTTCTGTAGCT
CAGTTCCCAGACAGCTTTTTAGGTAGTGGAGGAGGTGGCTTCATGTGGCACTTGGGCATTTATATTCCACTTGGGAGGGTCAGGCTGTGG
CCTTCTGGAGCAGGTGGCTTGTTAAGGAATGCTAGCAGGGCATGGCACGTGAGCTCCGGAATAGATGTCTTCATCACTTCTTCCACTGTG
TGTTGACACTGTTTTCCTTACCTATTTCCTCAGATCCCCAGCTTTCTCCTCTGCTATGCATTTTCTTCACAGTGCAGCTTGCAGTCCGTT
GCTGAAAATGATTATAAGCCCTGCATAATGTTAAGCTTTATTGTGATTACGTGTATGTTTCTTCTTTCTTTTAAGCAGACCCATACCTTT
CCAGGGTCAAAGTACAGAATAGAATACATTGATACAAAGTACAGAAAAATACTTTGATTTTTATCCATTTCTTTTACTCTGTGTAAAGAC
TTGAGAAGTCTAATTCACAGGCAAACCAATACAGAATTGACTGCAGTTGAACAGACTAGAAGTATTTGTGGGAGGAGTGACATGAAGCAT
GAGTTATCTGATTTTTTTTGTAGCTGCTATATATTTTAAGCCTTCATTTGCAATTCATGTAACAGTTGTGTCATAAATTACACAATAAAG
CAGTCCTGTTCAAATTTTTTTTTAACGTGGCTTGTAGAATTTTTAAAAAAGTGATCTTAGGTTTGTTTTTTCATGCGGGATGCAGATGGG
TGCTATCAGAGCCTCTCCCACACCACTATAGTGTAATAATGTTATTATTACTCTACACTGAAACGTATTCAGAGTTAGATATTATTTTAG
CTTCAGTTGTTCTTTAGAGGCTTTCAAATGTACCGATGATACTGTTTCTTGCACTGAATATATAAACACTCCACAGTGTTTATATTGGGA
AGATATTGGGAAGGAAATATATTTGTAAAAGATGAAGGCTGTATCTATTTTTTTTTCTTTTTAAAGTTTGTTCACTTAAATTCTTTTGAG
GATGGGATGTATTTTTCTTGCTGTTCAGTGCTTTTTCCTTTTCATCTGTTGTTCTGTGGTCACAGTGACCTTAGCTACATAGCAGACTTT
CCCAAATGTATTGATTACAAATAAACAGTTGTTACTTAGCAAGACCTGAAAATATGTCTGCAGGTTTCTCCTTGAAGCAAATGTGTGGGA
TCATTGCATTTCCAGAAATCTGCCTCCTTCACCCTCCGTTGACAGTATATGTCATGCCTCACTTTCTTCTAGCTGAGCTTTAAATCATTA
GAGCTTAAATTGTCAGATCGTTCATTGCCTTTCCAGGGTTATTTAGTAAAGTTTGTTGAAAACAAAAACGCCTTTTCTTGGTTCTTTTTT
CAGTTATTTTGAAGGTCCAGCATCCTGATTAAATGTCTGACACATTAATGAATGACCAGCAGCAGCTTTCAGCTCTTAAAAAGACACTTA
TATTTTGATTTTACATGCTGGTTACCTGTTCCATTGTTGTCAAATGCCCACTCTCCATCAGATGTGTTCCTCCATTTTCTTATCCACAAA
GTACTCCTCACTTTTCAATTTGTCATGTTACTAAATGGTGTTACATTAAAGCCCTGTGTTAAGTGTCAAAAAAAAGAAGAGACCATTCCT
GTGATCATTTCCCCCCTCAAGACCATATCAGCTTCTCTGGGGTCAAGACTGACAATCCCGTGTAAGGTGTTTCTGGGAACCGGCACACCC
TTAACCACCATGCTGTGGTGGACGGCCAATGACACCCACATAGAGAGCGCCTACCCGGGAGGCCGCGTGACCGAGGGGCCACGCCAGTAA
GTGGGCCAGGGTCTTCTGTTGAGAACTCTGTGGGTTTCGCTCTTCCTTTTGGAGACAGTTATCACTATGACCCACATACCACATTAAAAG

>In-frame_ENST00000452673_ENST00000441002_TCGA-CV-5443-01A_CANX_chr5_179157926_-_IL1R2_chr2_102638649_length(amino acids)=592AA_start in transcript=147_stop in transcript=1925
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKK
DDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFH
DKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPV
NPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRC
ESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDW
ANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDE

--------------------------------------------------------------
>In-frame_ENST00000247461_ENST00000332549_TCGA-CV-5443-01A_CANX_chr5_179157926_-_IL1R2_chr2_102638649_length(transcript)=4921nt_BP=4260nt
ACTCAGGGGCCAGGGGCGGGCACAGGGCCGGGCTTCGTGCGGTGGGGCTCGCTCGCGCGGCAGCGGTGGCCGAGGCCTCTTGGTTCTGCG
GCACGTGACGGTCGGGCCGCCTCCGCCTCTCTCTTTACTGCGGCGCGGGGCAAGGTGTGCGGGCGGGAAGGGGCACGGGCACCCCCGCGG
TCCCCGGGAGGCTAGAGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTGGTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGAC
ATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAGGTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTT
CATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTTGCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGA
TTTTATCCAAAGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGATGGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGC
TTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATCTCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCA
AGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGTGGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAAC
TCAACCTGGATCAGTTCCATGACAAGACCCCTTATACGATTATGTTTGGTCCAGATAAATGTGGAGAGGACTATAAACTGCACTTCATCT
TCCGACACAAAAACCCCAAAACGGGTATCTATGAAGAAAAACATGCTAAGAGGCCAGATGCAGATCTGAAGACCTATTTTACTGATAAGA
AAACACATCTTTACACACTAATCTTGAATCCAGATAATAGTTTTGAAATACTGGTTGACCAATCTGTGGTGAATAGTGGAAATCTGCTCA
ATGACATGACTCCTCCTGTAAATCCTTCACGTGAAATTGAGGACCCAGAAGACCGGAAGCCCGAGGATTGGGATGAAAGACCAAAAATCC
CAGATCCAGAAGCTGTCAAGCCAGATGACTGGGATGAAGATGCCCCTGCTAAGATTCCAGATGAAGAGGCCACAAAACCCGAAGGCTGGT
TAGATGATGAGCCTGAGTACGTACCTGATCCAGACGCAGAGAAACCTGAGGATTGGGATGAAGACATGGATGGAGAATGGGAGGCTCCTC
AGATTGCCAACCCTAGATGTGAGTCAGCTCCTGGATGTGGTGTCTGGCAGCGACCTGTGATTGACAACCCCAATTATAAAGGCAAATGGA
AGCCTCCTATGATTGACAATCCCAGTTACCAGGGAATCTGGAAACCCAGGAAAATACCAAATCCAGATTTCTTTGAAGATCTGGAACCTT
TCAGAATGACTCCTTTTAGTGCTATTGGTTTGGAGCTGTGGTCCATGACCTCTGACATTTTTTTTGACAACTTTATCATTTGTGCTGATC
GAAGAATAGTTGATGATTGGGCCAATGATGGATGGGGCCTGAAGAAAGCTGCTGATGGGGCTGCTGAGCCAGGCGTTGTGGGGCAGATGA
TCGAGGCAGCTGAAGAGCGCCCGTGGCTGTGGGTAGTCTATATTCTAACTGTAGCCCTTCCTGTGTTCCTGGTTATCCTCTTCTGCTGTT
CTGGAAAGAAACAGACCAGTGGTATGGAGTATAAGAAAACTGATGCACCTCAACCGGATGTGAAGGAAGAGGAAGAAGAGAAGGAAGAGG
AAAAGGACAAGGGAGATGAGGAGGAGGAAGGAGAAGAGAAACTTGAAGAGAAACAGAAAAGTGATGCTGAAGAAGATGGTGGCACTGTCA
GTCAAGAGGAGGAAGACAGAAAACCTAAAGCAGAGGAGGATGAAATTTTGAACAGATCACCAAGAAACAGAAAGCCACGAAGAGAGTGAA
ACAATCTTAAGAGCTTGATCTGTGATTTCTTCTCCCTCCTCCCCTGCAAGAGTGGTCCTAGGAGAGGACCTGGCACACCTTAGGTTGACA
TTCAGAAAACTTCAAGACATCACCATCAGCAGGCTCCAGTTGAACACTAGTCTGTGTAACTTTAAACATCTAGCAGTAAATACTTGCAGT
TGTGATATAAAGGACCCTGTTTCTGTAGAAAAGAAAACATTTAACATAATGGTTGTGAAATGTAACATGAAGCAAACTAACTTTTTTTTT
TTTAACATCTTTGTTTTTAAAATAGAATGATAGAACTTTGCCAGTCTTTAAGATCTTGGCTTAATTTAATGTATTAATCTGTTTGTGCAA
ACATAATACCACCATTTAAAAATGTTAGGGAGATGAGTTGCAGTTTTTATAATAGATTTTTTTTAAAGTTTGGTATTGTAAAACATTCAC
ACCTCTGTCCCTCAAAATTGATAATTACGTTTAAAGTGCAGTCATTTGTGGTTAGAATCTTGTTTTGTTTGCTTCCATTATTGAGTTCCT
CCTAAGGAAATTGAGGAGAGGGACTGAATAGAAGCCCAAATTCATATAAAAGTTGCGTTTAAGTTGTATTAAAAATAGATATATAAGAAA
AAATTCTTTCACTTGATGTTTGTTAGACCAGAAAGTGTGTGTGTTCTGTAGCTCAGTTCCCAGACAGCTTTTTAGGTAGTGGAGGAGGTG
GCTTCATGTGGCACTTGGGCATTTATATTCCACTTGGGAGGGTCAGGCTGTGGCCTTCTGGAGCAGGTGGCTTGTTAAGGAATGCTAGCA
GGGCATGGCACGTGAGCTCCGGAATAGATGTCTTCATCACTTCTTCCACTGTGTGTTGACACTGTTTTCCTTACCTATTTCCTCAGATCC
CCAGCTTTCTCCTCTGCTATGCATTTTCTTCACAGTGCAGCTTGCAGTCCGTTGCTGAAAATGATTATAAGCCCTGCATAATGTTAAGCT
TTATTGTGATTACGTGTATGTTTCTTCTTTCTTTTAAGCAGACCCATACCTTTCCAGGGTCAAAGTACAGAATAGAATACATTGATACAA
AGTACAGAAAAATACTTTGATTTTTATCCATTTCTTTTACTCTGTGTAAAGACTTGAGAAGTCTAATTCACAGGCAAACCAATACAGAAT
TGACTGCAGTTGAACAGACTAGAAGTATTTGTGGGAGGAGTGACATGAAGCATGAGTTATCTGATTTTTTTTGTAGCTGCTATATATTTT
AAGCCTTCATTTGCAATTCATGTAACAGTTGTGTCATAAATTACACAATAAAGCAGTCCTGTTCAAATTTTTTTTTAACGTGGCTTGTAG
AATTTTTAAAAAAGTGATCTTAGGTTTGTTTTTTCATGCGGGATGCAGATGGGTGCTATCAGAGCCTCTCCCACACCACTATAGTGTAAT
AATGTTATTATTACTCTACACTGAAACGTATTCAGAGTTAGATATTATTTTAGCTTCAGTTGTTCTTTAGAGGCTTTCAAATGTACCGAT
GATACTGTTTCTTGCACTGAATATATAAACACTCCACAGTGTTTATATTGGGAAGATATTGGGAAGGAAATATATTTGTAAAAGATGAAG
GCTGTATCTATTTTTTTTTCTTTTTAAAGTTTGTTCACTTAAATTCTTTTGAGGATGGGATGTATTTTTCTTGCTGTTCAGTGCTTTTTC
CTTTTCATCTGTTGTTCTGTGGTCACAGTGACCTTAGCTACATAGCAGACTTTCCCAAATGTATTGATTACAAATAAACAGTTGTTACTT
AGCAAGACCTGAAAATATGTCTGCAGGTTTCTCCTTGAAGCAAATGTGTGGGATCATTGCATTTCCAGAAATCTGCCTCCTTCACCCTCC
GTTGACAGTATATGTCATGCCTCACTTTCTTCTAGCTGAGCTTTAAATCATTAGAGCTTAAATTGTCAGATCGTTCATTGCCTTTCCAGG
GTTATTTAGTAAAGTTTGTTGAAAACAAAAACGCCTTTTCTTGGTTCTTTTTTCAGTTATTTTGAAGGTCCAGCATCCTGATTAAATGTC
TGACACATTAATGAATGACCAGCAGCAGCTTTCAGCTCTTAAAAAGACACTTATATTTTGATTTTACATGCTGGTTACCTGTTCCATTGT
TGTCAAATGCCCACTCTCCATCAGATGTGTTCCTCCATTTTCTTATCCACAAAGTACTCCTCACTTTTCAATTTGTCATGTTACTAAATG
GTGTTACATTAAAGCCCTGTGTTAAGTGTCAAAAAAAAGAAGAGACCATTCCTGTGATCATTTCCCCCCTCAAGACCATATCAGCTTCTC
TGGGGTCAAGACTGACAATCCCGTGTAAGGTGTTTCTGGGAACCGGCACACCCTTAACCACCATGCTGTGGTGGACGGCCAATGACACCC
ACATAGAGAGCGCCTACCCGGGAGGCCGCGTGACCGAGGGGCCACGCCAGGAATATTCAGAAAATAATGAGAACTACATTGAAGTGCCAT
TGATTTTTGATCCTGTCACAAGAGAGGATTTGCACATGGATTTTAAATGTGTTGTCCATAATACCCTGAGTTTTCAGACACTACGCACCA
CAGTCAAGGAAGCCTCCTCCACGTTCTCCTGGGGCATTGTGCTGGCCCCACTTTCACTGGCCTTCTTGGTTTTGGGGGGAATATGGATGC
ACAGACGGTGCAAACACAGAACTGGAAAAGCAGATGGTCTGACTGTGCTATGGCCTCATCATCAAGACTTTCAATCCTATCCCAAGTGAA
ATAAATGGAATGAAATAATTCAAACACAAACTCCGTACGTCTTCTCTTATGGAAGTGGCTGTGTCTTTTTGAGGGACTCTGTTCTTTGCC

>In-frame_ENST00000247461_ENST00000332549_TCGA-CV-5443-01A_CANX_chr5_179157926_-_IL1R2_chr2_102638649_length(amino acids)=592AA_start in transcript=200_stop in transcript=1978
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKK
DDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFH
DKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPV
NPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRC
ESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDW
ANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDE

--------------------------------------------------------------
>In-frame_ENST00000247461_ENST00000393414_TCGA-CV-5443-01A_CANX_chr5_179157926_-_IL1R2_chr2_102638649_length(transcript)=4794nt_BP=4260nt
ACTCAGGGGCCAGGGGCGGGCACAGGGCCGGGCTTCGTGCGGTGGGGCTCGCTCGCGCGGCAGCGGTGGCCGAGGCCTCTTGGTTCTGCG
GCACGTGACGGTCGGGCCGCCTCCGCCTCTCTCTTTACTGCGGCGCGGGGCAAGGTGTGCGGGCGGGAAGGGGCACGGGCACCCCCGCGG
TCCCCGGGAGGCTAGAGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTGGTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGAC
ATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAGGTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTT
CATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTTGCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGA
TTTTATCCAAAGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGATGGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGC
TTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATCTCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCA
AGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGTGGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAAC
TCAACCTGGATCAGTTCCATGACAAGACCCCTTATACGATTATGTTTGGTCCAGATAAATGTGGAGAGGACTATAAACTGCACTTCATCT
TCCGACACAAAAACCCCAAAACGGGTATCTATGAAGAAAAACATGCTAAGAGGCCAGATGCAGATCTGAAGACCTATTTTACTGATAAGA
AAACACATCTTTACACACTAATCTTGAATCCAGATAATAGTTTTGAAATACTGGTTGACCAATCTGTGGTGAATAGTGGAAATCTGCTCA
ATGACATGACTCCTCCTGTAAATCCTTCACGTGAAATTGAGGACCCAGAAGACCGGAAGCCCGAGGATTGGGATGAAAGACCAAAAATCC
CAGATCCAGAAGCTGTCAAGCCAGATGACTGGGATGAAGATGCCCCTGCTAAGATTCCAGATGAAGAGGCCACAAAACCCGAAGGCTGGT
TAGATGATGAGCCTGAGTACGTACCTGATCCAGACGCAGAGAAACCTGAGGATTGGGATGAAGACATGGATGGAGAATGGGAGGCTCCTC
AGATTGCCAACCCTAGATGTGAGTCAGCTCCTGGATGTGGTGTCTGGCAGCGACCTGTGATTGACAACCCCAATTATAAAGGCAAATGGA
AGCCTCCTATGATTGACAATCCCAGTTACCAGGGAATCTGGAAACCCAGGAAAATACCAAATCCAGATTTCTTTGAAGATCTGGAACCTT
TCAGAATGACTCCTTTTAGTGCTATTGGTTTGGAGCTGTGGTCCATGACCTCTGACATTTTTTTTGACAACTTTATCATTTGTGCTGATC
GAAGAATAGTTGATGATTGGGCCAATGATGGATGGGGCCTGAAGAAAGCTGCTGATGGGGCTGCTGAGCCAGGCGTTGTGGGGCAGATGA
TCGAGGCAGCTGAAGAGCGCCCGTGGCTGTGGGTAGTCTATATTCTAACTGTAGCCCTTCCTGTGTTCCTGGTTATCCTCTTCTGCTGTT
CTGGAAAGAAACAGACCAGTGGTATGGAGTATAAGAAAACTGATGCACCTCAACCGGATGTGAAGGAAGAGGAAGAAGAGAAGGAAGAGG
AAAAGGACAAGGGAGATGAGGAGGAGGAAGGAGAAGAGAAACTTGAAGAGAAACAGAAAAGTGATGCTGAAGAAGATGGTGGCACTGTCA
GTCAAGAGGAGGAAGACAGAAAACCTAAAGCAGAGGAGGATGAAATTTTGAACAGATCACCAAGAAACAGAAAGCCACGAAGAGAGTGAA
ACAATCTTAAGAGCTTGATCTGTGATTTCTTCTCCCTCCTCCCCTGCAAGAGTGGTCCTAGGAGAGGACCTGGCACACCTTAGGTTGACA
TTCAGAAAACTTCAAGACATCACCATCAGCAGGCTCCAGTTGAACACTAGTCTGTGTAACTTTAAACATCTAGCAGTAAATACTTGCAGT
TGTGATATAAAGGACCCTGTTTCTGTAGAAAAGAAAACATTTAACATAATGGTTGTGAAATGTAACATGAAGCAAACTAACTTTTTTTTT
TTTAACATCTTTGTTTTTAAAATAGAATGATAGAACTTTGCCAGTCTTTAAGATCTTGGCTTAATTTAATGTATTAATCTGTTTGTGCAA
ACATAATACCACCATTTAAAAATGTTAGGGAGATGAGTTGCAGTTTTTATAATAGATTTTTTTTAAAGTTTGGTATTGTAAAACATTCAC
ACCTCTGTCCCTCAAAATTGATAATTACGTTTAAAGTGCAGTCATTTGTGGTTAGAATCTTGTTTTGTTTGCTTCCATTATTGAGTTCCT
CCTAAGGAAATTGAGGAGAGGGACTGAATAGAAGCCCAAATTCATATAAAAGTTGCGTTTAAGTTGTATTAAAAATAGATATATAAGAAA
AAATTCTTTCACTTGATGTTTGTTAGACCAGAAAGTGTGTGTGTTCTGTAGCTCAGTTCCCAGACAGCTTTTTAGGTAGTGGAGGAGGTG
GCTTCATGTGGCACTTGGGCATTTATATTCCACTTGGGAGGGTCAGGCTGTGGCCTTCTGGAGCAGGTGGCTTGTTAAGGAATGCTAGCA
GGGCATGGCACGTGAGCTCCGGAATAGATGTCTTCATCACTTCTTCCACTGTGTGTTGACACTGTTTTCCTTACCTATTTCCTCAGATCC
CCAGCTTTCTCCTCTGCTATGCATTTTCTTCACAGTGCAGCTTGCAGTCCGTTGCTGAAAATGATTATAAGCCCTGCATAATGTTAAGCT
TTATTGTGATTACGTGTATGTTTCTTCTTTCTTTTAAGCAGACCCATACCTTTCCAGGGTCAAAGTACAGAATAGAATACATTGATACAA
AGTACAGAAAAATACTTTGATTTTTATCCATTTCTTTTACTCTGTGTAAAGACTTGAGAAGTCTAATTCACAGGCAAACCAATACAGAAT
TGACTGCAGTTGAACAGACTAGAAGTATTTGTGGGAGGAGTGACATGAAGCATGAGTTATCTGATTTTTTTTGTAGCTGCTATATATTTT
AAGCCTTCATTTGCAATTCATGTAACAGTTGTGTCATAAATTACACAATAAAGCAGTCCTGTTCAAATTTTTTTTTAACGTGGCTTGTAG
AATTTTTAAAAAAGTGATCTTAGGTTTGTTTTTTCATGCGGGATGCAGATGGGTGCTATCAGAGCCTCTCCCACACCACTATAGTGTAAT
AATGTTATTATTACTCTACACTGAAACGTATTCAGAGTTAGATATTATTTTAGCTTCAGTTGTTCTTTAGAGGCTTTCAAATGTACCGAT
GATACTGTTTCTTGCACTGAATATATAAACACTCCACAGTGTTTATATTGGGAAGATATTGGGAAGGAAATATATTTGTAAAAGATGAAG
GCTGTATCTATTTTTTTTTCTTTTTAAAGTTTGTTCACTTAAATTCTTTTGAGGATGGGATGTATTTTTCTTGCTGTTCAGTGCTTTTTC
CTTTTCATCTGTTGTTCTGTGGTCACAGTGACCTTAGCTACATAGCAGACTTTCCCAAATGTATTGATTACAAATAAACAGTTGTTACTT
AGCAAGACCTGAAAATATGTCTGCAGGTTTCTCCTTGAAGCAAATGTGTGGGATCATTGCATTTCCAGAAATCTGCCTCCTTCACCCTCC
GTTGACAGTATATGTCATGCCTCACTTTCTTCTAGCTGAGCTTTAAATCATTAGAGCTTAAATTGTCAGATCGTTCATTGCCTTTCCAGG
GTTATTTAGTAAAGTTTGTTGAAAACAAAAACGCCTTTTCTTGGTTCTTTTTTCAGTTATTTTGAAGGTCCAGCATCCTGATTAAATGTC
TGACACATTAATGAATGACCAGCAGCAGCTTTCAGCTCTTAAAAAGACACTTATATTTTGATTTTACATGCTGGTTACCTGTTCCATTGT
TGTCAAATGCCCACTCTCCATCAGATGTGTTCCTCCATTTTCTTATCCACAAAGTACTCCTCACTTTTCAATTTGTCATGTTACTAAATG
GTGTTACATTAAAGCCCTGTGTTAAGTGTCAAAAAAAAGAAGAGACCATTCCTGTGATCATTTCCCCCCTCAAGACCATATCAGCTTCTC
TGGGGTCAAGACTGACAATCCCGTGTAAGGTGTTTCTGGGAACCGGCACACCCTTAACCACCATGCTGTGGTGGACGGCCAATGACACCC
ACATAGAGAGCGCCTACCCGGGAGGCCGCGTGACCGAGGGGCCACGCCAGGAATATTCAGAAAATAATGAGAACTACATTGAAGTGCCAT
TGATTTTTGATCCTGTCACAAGAGAGGATTTGCACATGGATTTTAAATGTGTTGTCCATAATACCCTGAGTTTTCAGACACTACGCACCA
CAGTCAAGGAAGCCTCCTCCACGTTCTCCTGGGGCATTGTGCTGGCCCCACTTTCACTGGCCTTCTTGGTTTTGGGGGGAATATGGATGC
ACAGACGGTGCAAACACAGAACTGGAAAAGCAGATGGTCTGACTGTGCTATGGCCTCATCATCAAGACTTTCAATCCTATCCCAAGTGAA

>In-frame_ENST00000247461_ENST00000393414_TCGA-CV-5443-01A_CANX_chr5_179157926_-_IL1R2_chr2_102638649_length(amino acids)=592AA_start in transcript=200_stop in transcript=1978
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKK
DDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFH
DKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPV
NPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRC
ESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDW
ANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDE

--------------------------------------------------------------
>In-frame_ENST00000247461_ENST00000441002_TCGA-CV-5443-01A_CANX_chr5_179157926_-_IL1R2_chr2_102638649_length(transcript)=4617nt_BP=4260nt
ACTCAGGGGCCAGGGGCGGGCACAGGGCCGGGCTTCGTGCGGTGGGGCTCGCTCGCGCGGCAGCGGTGGCCGAGGCCTCTTGGTTCTGCG
GCACGTGACGGTCGGGCCGCCTCCGCCTCTCTCTTTACTGCGGCGCGGGGCAAGGTGTGCGGGCGGGAAGGGGCACGGGCACCCCCGCGG
TCCCCGGGAGGCTAGAGATCATGGAAGGGAAGTGGTTGCTGTGTATGTTACTGGTGCTTGGAACTGCTATTGTTGAGGCTCATGATGGAC
ATGATGATGATGTGATTGATATTGAGGATGACCTTGACGATGTCATTGAAGAGGTAGAAGACTCAAAACCAGATACCACTGCTCCTCCTT
CATCTCCCAAGGTTACTTACAAAGCTCCAGTTCCAACAGGGGAAGTATATTTTGCTGATTCTTTTGACAGAGGAACTCTGTCAGGGTGGA
TTTTATCCAAAGCCAAGAAAGACGATACCGATGATGAAATTGCCAAATATGATGGAAAGTGGGAGGTAGAGGAAATGAAGGAGTCAAAGC
TTCCAGGTGATAAAGGACTTGTGTTGATGTCTCGGGCCAAGCATCATGCCATCTCTGCTAAACTGAACAAGCCCTTCCTGTTTGACACCA
AGCCTCTCATTGTTCAGTATGAGGTTAATTTCCAAAATGGAATAGAATGTGGTGGTGCCTATGTGAAACTGCTTTCTAAAACACCAGAAC
TCAACCTGGATCAGTTCCATGACAAGACCCCTTATACGATTATGTTTGGTCCAGATAAATGTGGAGAGGACTATAAACTGCACTTCATCT
TCCGACACAAAAACCCCAAAACGGGTATCTATGAAGAAAAACATGCTAAGAGGCCAGATGCAGATCTGAAGACCTATTTTACTGATAAGA
AAACACATCTTTACACACTAATCTTGAATCCAGATAATAGTTTTGAAATACTGGTTGACCAATCTGTGGTGAATAGTGGAAATCTGCTCA
ATGACATGACTCCTCCTGTAAATCCTTCACGTGAAATTGAGGACCCAGAAGACCGGAAGCCCGAGGATTGGGATGAAAGACCAAAAATCC
CAGATCCAGAAGCTGTCAAGCCAGATGACTGGGATGAAGATGCCCCTGCTAAGATTCCAGATGAAGAGGCCACAAAACCCGAAGGCTGGT
TAGATGATGAGCCTGAGTACGTACCTGATCCAGACGCAGAGAAACCTGAGGATTGGGATGAAGACATGGATGGAGAATGGGAGGCTCCTC
AGATTGCCAACCCTAGATGTGAGTCAGCTCCTGGATGTGGTGTCTGGCAGCGACCTGTGATTGACAACCCCAATTATAAAGGCAAATGGA
AGCCTCCTATGATTGACAATCCCAGTTACCAGGGAATCTGGAAACCCAGGAAAATACCAAATCCAGATTTCTTTGAAGATCTGGAACCTT
TCAGAATGACTCCTTTTAGTGCTATTGGTTTGGAGCTGTGGTCCATGACCTCTGACATTTTTTTTGACAACTTTATCATTTGTGCTGATC
GAAGAATAGTTGATGATTGGGCCAATGATGGATGGGGCCTGAAGAAAGCTGCTGATGGGGCTGCTGAGCCAGGCGTTGTGGGGCAGATGA
TCGAGGCAGCTGAAGAGCGCCCGTGGCTGTGGGTAGTCTATATTCTAACTGTAGCCCTTCCTGTGTTCCTGGTTATCCTCTTCTGCTGTT
CTGGAAAGAAACAGACCAGTGGTATGGAGTATAAGAAAACTGATGCACCTCAACCGGATGTGAAGGAAGAGGAAGAAGAGAAGGAAGAGG
AAAAGGACAAGGGAGATGAGGAGGAGGAAGGAGAAGAGAAACTTGAAGAGAAACAGAAAAGTGATGCTGAAGAAGATGGTGGCACTGTCA
GTCAAGAGGAGGAAGACAGAAAACCTAAAGCAGAGGAGGATGAAATTTTGAACAGATCACCAAGAAACAGAAAGCCACGAAGAGAGTGAA
ACAATCTTAAGAGCTTGATCTGTGATTTCTTCTCCCTCCTCCCCTGCAAGAGTGGTCCTAGGAGAGGACCTGGCACACCTTAGGTTGACA
TTCAGAAAACTTCAAGACATCACCATCAGCAGGCTCCAGTTGAACACTAGTCTGTGTAACTTTAAACATCTAGCAGTAAATACTTGCAGT
TGTGATATAAAGGACCCTGTTTCTGTAGAAAAGAAAACATTTAACATAATGGTTGTGAAATGTAACATGAAGCAAACTAACTTTTTTTTT
TTTAACATCTTTGTTTTTAAAATAGAATGATAGAACTTTGCCAGTCTTTAAGATCTTGGCTTAATTTAATGTATTAATCTGTTTGTGCAA
ACATAATACCACCATTTAAAAATGTTAGGGAGATGAGTTGCAGTTTTTATAATAGATTTTTTTTAAAGTTTGGTATTGTAAAACATTCAC
ACCTCTGTCCCTCAAAATTGATAATTACGTTTAAAGTGCAGTCATTTGTGGTTAGAATCTTGTTTTGTTTGCTTCCATTATTGAGTTCCT
CCTAAGGAAATTGAGGAGAGGGACTGAATAGAAGCCCAAATTCATATAAAAGTTGCGTTTAAGTTGTATTAAAAATAGATATATAAGAAA
AAATTCTTTCACTTGATGTTTGTTAGACCAGAAAGTGTGTGTGTTCTGTAGCTCAGTTCCCAGACAGCTTTTTAGGTAGTGGAGGAGGTG
GCTTCATGTGGCACTTGGGCATTTATATTCCACTTGGGAGGGTCAGGCTGTGGCCTTCTGGAGCAGGTGGCTTGTTAAGGAATGCTAGCA
GGGCATGGCACGTGAGCTCCGGAATAGATGTCTTCATCACTTCTTCCACTGTGTGTTGACACTGTTTTCCTTACCTATTTCCTCAGATCC
CCAGCTTTCTCCTCTGCTATGCATTTTCTTCACAGTGCAGCTTGCAGTCCGTTGCTGAAAATGATTATAAGCCCTGCATAATGTTAAGCT
TTATTGTGATTACGTGTATGTTTCTTCTTTCTTTTAAGCAGACCCATACCTTTCCAGGGTCAAAGTACAGAATAGAATACATTGATACAA
AGTACAGAAAAATACTTTGATTTTTATCCATTTCTTTTACTCTGTGTAAAGACTTGAGAAGTCTAATTCACAGGCAAACCAATACAGAAT
TGACTGCAGTTGAACAGACTAGAAGTATTTGTGGGAGGAGTGACATGAAGCATGAGTTATCTGATTTTTTTTGTAGCTGCTATATATTTT
AAGCCTTCATTTGCAATTCATGTAACAGTTGTGTCATAAATTACACAATAAAGCAGTCCTGTTCAAATTTTTTTTTAACGTGGCTTGTAG
AATTTTTAAAAAAGTGATCTTAGGTTTGTTTTTTCATGCGGGATGCAGATGGGTGCTATCAGAGCCTCTCCCACACCACTATAGTGTAAT
AATGTTATTATTACTCTACACTGAAACGTATTCAGAGTTAGATATTATTTTAGCTTCAGTTGTTCTTTAGAGGCTTTCAAATGTACCGAT
GATACTGTTTCTTGCACTGAATATATAAACACTCCACAGTGTTTATATTGGGAAGATATTGGGAAGGAAATATATTTGTAAAAGATGAAG
GCTGTATCTATTTTTTTTTCTTTTTAAAGTTTGTTCACTTAAATTCTTTTGAGGATGGGATGTATTTTTCTTGCTGTTCAGTGCTTTTTC
CTTTTCATCTGTTGTTCTGTGGTCACAGTGACCTTAGCTACATAGCAGACTTTCCCAAATGTATTGATTACAAATAAACAGTTGTTACTT
AGCAAGACCTGAAAATATGTCTGCAGGTTTCTCCTTGAAGCAAATGTGTGGGATCATTGCATTTCCAGAAATCTGCCTCCTTCACCCTCC
GTTGACAGTATATGTCATGCCTCACTTTCTTCTAGCTGAGCTTTAAATCATTAGAGCTTAAATTGTCAGATCGTTCATTGCCTTTCCAGG
GTTATTTAGTAAAGTTTGTTGAAAACAAAAACGCCTTTTCTTGGTTCTTTTTTCAGTTATTTTGAAGGTCCAGCATCCTGATTAAATGTC
TGACACATTAATGAATGACCAGCAGCAGCTTTCAGCTCTTAAAAAGACACTTATATTTTGATTTTACATGCTGGTTACCTGTTCCATTGT
TGTCAAATGCCCACTCTCCATCAGATGTGTTCCTCCATTTTCTTATCCACAAAGTACTCCTCACTTTTCAATTTGTCATGTTACTAAATG
GTGTTACATTAAAGCCCTGTGTTAAGTGTCAAAAAAAAGAAGAGACCATTCCTGTGATCATTTCCCCCCTCAAGACCATATCAGCTTCTC
TGGGGTCAAGACTGACAATCCCGTGTAAGGTGTTTCTGGGAACCGGCACACCCTTAACCACCATGCTGTGGTGGACGGCCAATGACACCC
ACATAGAGAGCGCCTACCCGGGAGGCCGCGTGACCGAGGGGCCACGCCAGTAAGTGGGCCAGGGTCTTCTGTTGAGAACTCTGTGGGTTT
CGCTCTTCCTTTTGGAGACAGTTATCACTATGACCCACATACCACATTAAAAGTTACTTTTTTTGATTCCAAACTGTTGGATGTTTAGAA

>In-frame_ENST00000247461_ENST00000441002_TCGA-CV-5443-01A_CANX_chr5_179157926_-_IL1R2_chr2_102638649_length(amino acids)=592AA_start in transcript=200_stop in transcript=1978
MEGKWLLCMLLVLGTAIVEAHDGHDDDVIDIEDDLDDVIEEVEDSKPDTTAPPSSPKVTYKAPVPTGEVYFADSFDRGTLSGWILSKAKK
DDTDDEIAKYDGKWEVEEMKESKLPGDKGLVLMSRAKHHAISAKLNKPFLFDTKPLIVQYEVNFQNGIECGGAYVKLLSKTPELNLDQFH
DKTPYTIMFGPDKCGEDYKLHFIFRHKNPKTGIYEEKHAKRPDADLKTYFTDKKTHLYTLILNPDNSFEILVDQSVVNSGNLLNDMTPPV
NPSREIEDPEDRKPEDWDERPKIPDPEAVKPDDWDEDAPAKIPDEEATKPEGWLDDEPEYVPDPDAEKPEDWDEDMDGEWEAPQIANPRC
ESAPGCGVWQRPVIDNPNYKGKWKPPMIDNPSYQGIWKPRKIPNPDFFEDLEPFRMTPFSAIGLELWSMTSDIFFDNFIICADRRIVDDW
ANDGWGLKKAADGAAEPGVVGQMIEAAEERPWLWVVYILTVALPVFLVILFCCSGKKQTSGMEYKKTDAPQPDVKEEEEEKEEEKDKGDE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CANX-IL1R2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneCANXchr5:179157926chr2:102638649ENST00000247461-1515326_3591353.3333333333333593.0PPIB
HgeneCANXchr5:179157926chr2:102638649ENST00000452673-1515326_3591353.3333333333333593.0PPIB


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCANXchr5:179157926chr2:102638649ENST00000504734-115326_3590593.0PPIB


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CANX-IL1R2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CANX-IL1R2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCANXC0019193Hepatitis, Toxic1CTD_human
HgeneCANXC0151744Myocardial Ischemia1CTD_human
HgeneCANXC0860207Drug-Induced Liver Disease1CTD_human
HgeneCANXC1262760Hepatitis, Drug-Induced1CTD_human
HgeneCANXC3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneCANXC4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneCANXC4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneIL1R2C0009324Ulcerative Colitis1CTD_human
TgeneIL1R2C0019193Hepatitis, Toxic1CTD_human
TgeneIL1R2C0020517Hypersensitivity1CTD_human
TgeneIL1R2C0023895Liver diseases1CTD_human
TgeneIL1R2C0024121Lung Neoplasms1CTD_human
TgeneIL1R2C0032285Pneumonia1CTD_human
TgeneIL1R2C0032300Lobar Pneumonia1CTD_human
TgeneIL1R2C0038013Ankylosing spondylitis1CTD_human
TgeneIL1R2C0086565Liver Dysfunction1CTD_human
TgeneIL1R2C0242379Malignant neoplasm of lung1CTD_human
TgeneIL1R2C0860207Drug-Induced Liver Disease1CTD_human
TgeneIL1R2C0887898Experimental Lung Inflammation1CTD_human
TgeneIL1R2C1262760Hepatitis, Drug-Induced1CTD_human
TgeneIL1R2C1527304Allergic Reaction1CTD_human
TgeneIL1R2C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneIL1R2C3714636Pneumonitis1CTD_human
TgeneIL1R2C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneIL1R2C4279912Chemically-Induced Liver Toxicity1CTD_human