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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACACA-PRPSAP2 (FusionGDB2 ID:1297)

Fusion Gene Summary for ACACA-PRPSAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ACACA-PRPSAP2
Fusion gene ID: 1297
HgeneTgene
Gene symbol

ACACA

PRPSAP2

Gene ID

31

5636

Gene nameacetyl-CoA carboxylase alphaphosphoribosyl pyrophosphate synthetase associated protein 2
SynonymsACAC|ACACAD|ACC|ACC1|ACCAPAP41
Cytomap

17q12

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionacetyl-CoA carboxylase 1ACC-alphaacetyl-Coenzyme A carboxylase alphaphosphoribosyl pyrophosphate synthase-associated protein 241 kDa phosphoribosypyrophosphate synthetase-associated proteinPRPP synthase-associated protein 2
Modification date2020031320200313
UniProtAcc

Q13085

.
Ensembl transtripts involved in fusion geneENST00000353139, ENST00000360679, 
ENST00000394406, ENST00000335166, 
ENST00000416895, ENST00000361253, 
ENST00000588142, ENST00000589665, 
ENST00000419071, ENST00000268835, 
ENST00000536323, ENST00000542013, 
ENST00000575337, 
Fusion gene scores* DoF score44 X 35 X 17=2618011 X 10 X 8=880
# samples 5113
** MAII scorelog2(51/26180*10)=-5.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/880*10)=-2.75899190049621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACACA [Title/Abstract] AND PRPSAP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACACA(35766352)-PRPSAP2(18793135), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ACACA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PRPSAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315434ACACAchr17

35766352

-PRPSAP2chr17

18793135

+


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Fusion Gene ORF analysis for ACACA-PRPSAP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000353139ENST00000419071ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
In-frameENST00000353139ENST00000268835ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
In-frameENST00000353139ENST00000536323ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
In-frameENST00000353139ENST00000542013ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
5CDS-3UTRENST00000353139ENST00000575337ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000360679ENST00000419071ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000360679ENST00000268835ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000360679ENST00000536323ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000360679ENST00000542013ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3UTRENST00000360679ENST00000575337ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000394406ENST00000419071ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000394406ENST00000268835ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000394406ENST00000536323ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000394406ENST00000542013ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3UTRENST00000394406ENST00000575337ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000335166ENST00000419071ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000335166ENST00000268835ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000335166ENST00000536323ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000335166ENST00000542013ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3UTRENST00000335166ENST00000575337ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
5UTR-3CDSENST00000416895ENST00000419071ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
5UTR-3CDSENST00000416895ENST00000268835ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
5UTR-3CDSENST00000416895ENST00000536323ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
5UTR-3CDSENST00000416895ENST00000542013ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
5UTR-3UTRENST00000416895ENST00000575337ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000361253ENST00000419071ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000361253ENST00000268835ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000361253ENST00000536323ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000361253ENST00000542013ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3UTRENST00000361253ENST00000575337ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000588142ENST00000419071ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000588142ENST00000268835ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000588142ENST00000536323ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3CDSENST00000588142ENST00000542013ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
intron-3UTRENST00000588142ENST00000575337ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
5UTR-3CDSENST00000589665ENST00000419071ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
5UTR-3CDSENST00000589665ENST00000268835ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
5UTR-3CDSENST00000589665ENST00000536323ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
5UTR-3CDSENST00000589665ENST00000542013ACACAchr17

35766352

-PRPSAP2chr17

18793135

+
5UTR-3UTRENST00000589665ENST00000575337ACACAchr17

35766352

-PRPSAP2chr17

18793135

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000353139ACACAchr1735766352-ENST00000419071PRPSAP2chr1718793135+1398520987448179
ENST00000353139ACACAchr1735766352-ENST00000268835PRPSAP2chr1718793135+1619520987448179
ENST00000353139ACACAchr1735766352-ENST00000536323PRPSAP2chr1718793135+1428520987448179
ENST00000353139ACACAchr1735766352-ENST00000542013PRPSAP2chr1718793135+991520840448130

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000353139ENST00000419071ACACAchr1735766352-PRPSAP2chr1718793135+0.0074183590.9925816
ENST00000353139ENST00000268835ACACAchr1735766352-PRPSAP2chr1718793135+0.0063024350.9936976
ENST00000353139ENST00000536323ACACAchr1735766352-PRPSAP2chr1718793135+0.0080847960.9919152
ENST00000353139ENST00000542013ACACAchr1735766352-PRPSAP2chr1718793135+0.081606180.9183938

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Fusion Genomic Features for ACACA-PRPSAP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACACAchr1735766351-PRPSAP2chr1718793134+2.54E-070.99999976
ACACAchr1735766351-PRPSAP2chr1718793134+2.54E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACACA-PRPSAP2


check button Go to

FGviewer for the breakpoints of chr17:35766352-chr17:18793135

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACACA

Q13085

.
FUNCTION: Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis (PubMed:20952656, PubMed:20457939, PubMed:29899443). This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed:20952656, PubMed:20457939, PubMed:29899443). {ECO:0000269|PubMed:20457939, ECO:0000269|PubMed:20952656, ECO:0000269|PubMed:29899443}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACACAchr17:35766352chr17:18793135ENST00000335166-155117_61802269.0DomainBiotin carboxylation
HgeneACACAchr17:35766352chr17:18793135ENST00000335166-1551576_191402269.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35766352chr17:18793135ENST00000335166-1551918_223402269.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35766352chr17:18793135ENST00000335166-155275_46602269.0DomainATP-grasp
HgeneACACAchr17:35766352chr17:18793135ENST00000335166-155745_81902269.0DomainBiotinyl-binding
HgeneACACAchr17:35766352chr17:18793135ENST00000353139-156117_61812.6666666666666662384.0DomainBiotin carboxylation
HgeneACACAchr17:35766352chr17:18793135ENST00000353139-1561576_191412.6666666666666662384.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35766352chr17:18793135ENST00000353139-1561918_223412.6666666666666662384.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35766352chr17:18793135ENST00000353139-156275_46612.6666666666666662384.0DomainATP-grasp
HgeneACACAchr17:35766352chr17:18793135ENST00000353139-156745_81912.6666666666666662384.0DomainBiotinyl-binding
HgeneACACAchr17:35766352chr17:18793135ENST00000360679-154117_61802289.0DomainBiotin carboxylation
HgeneACACAchr17:35766352chr17:18793135ENST00000360679-1541576_191402289.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35766352chr17:18793135ENST00000360679-1541918_223402289.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35766352chr17:18793135ENST00000360679-154275_46602289.0DomainATP-grasp
HgeneACACAchr17:35766352chr17:18793135ENST00000360679-154745_81902289.0DomainBiotinyl-binding
HgeneACACAchr17:35766352chr17:18793135ENST00000394406-156117_61802347.0DomainBiotin carboxylation
HgeneACACAchr17:35766352chr17:18793135ENST00000394406-1561576_191402347.0DomainCoA carboxyltransferase N-terminal
HgeneACACAchr17:35766352chr17:18793135ENST00000394406-1561918_223402347.0DomainCoA carboxyltransferase C-terminal
HgeneACACAchr17:35766352chr17:18793135ENST00000394406-156275_46602347.0DomainATP-grasp
HgeneACACAchr17:35766352chr17:18793135ENST00000394406-156745_81902347.0DomainBiotinyl-binding
HgeneACACAchr17:35766352chr17:18793135ENST00000335166-155315_32002269.0Nucleotide bindingATP
HgeneACACAchr17:35766352chr17:18793135ENST00000353139-156315_32012.6666666666666662384.0Nucleotide bindingATP
HgeneACACAchr17:35766352chr17:18793135ENST00000360679-154315_32002289.0Nucleotide bindingATP
HgeneACACAchr17:35766352chr17:18793135ENST00000394406-156315_32002347.0Nucleotide bindingATP
HgeneACACAchr17:35766352chr17:18793135ENST00000335166-1551576_223402269.0RegionCarboxyltransferase
HgeneACACAchr17:35766352chr17:18793135ENST00000353139-1561576_223412.6666666666666662384.0RegionCarboxyltransferase
HgeneACACAchr17:35766352chr17:18793135ENST00000360679-1541576_223402289.0RegionCarboxyltransferase
HgeneACACAchr17:35766352chr17:18793135ENST00000394406-1561576_223402347.0RegionCarboxyltransferase


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Fusion Gene Sequence for ACACA-PRPSAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000353139_ENST00000419071_ERR315434_ACACA_chr17_35766352_-_PRPSAP2_chr17_18793135_length(transcript)=1398nt_BP=520nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGATCCCAGATTACAGGAATGC
AGTAATCGTGGCCAAGTCTCCAGCCTCGGCGAAGAGGGCACAGTCTTTTGCTGAGCGCCTGCGCCTGGGAATTGCAGTGATTCATGGAGA
GGCGCAGGATGCCGAGTCGGACTTGGTGGATGGACGGCATTCCCCACCCATGGTCAGAAGTGTGGCTGCCATCCACCCCAGCCTGGAGAT
CCCCATGCTGATTCCTAAAGAAAAGCCCCCAATCACGGTTGTGGGTGATGTTGGAGGAAGGATTGCCATCATCGTGGATGACATCATTGA
TGATGTTGACAGCTTTCTTGCTGCAGCAGAGACCCTGAAGGAAAGAGGTGCATATAAGATCTTTGTGATGGCAACTCATGGCTTGTTGTC
TTCTGACGCCCCCCGGCGGATTGAAGAGTCTGCCATTGATGAGGTGGTGGTCACCAATACAATTCCACATGAAGTCCAGAAGCTCCAGTG
CCCCAAGATTAAAACTGTGGATATCAGCATGATCCTTTCAGAGGCGATCCGTCGGATCCACAATGGGGAGTCCATGTCCTACCTTTTCAG
AAACATAGGCTTAGATGACTGAGTTTTCCTTTAGGAAAACTCCCGAGGGCCAAACTGGAAACATAAGAGTGACTGCTCGGTGGGATGGAT
TTCACAGGAACCGTCATGCTTGTTCCTCCCTCTCCCCTGTAACCTCACTTCTTATTGATTCCTAAGAAGATAGACCAACTTTTTATGTCG
GTTTGGGTGTTTGTGAGTTTGGGGAGCAATTTTTATAAAAGAAAAACTTTATTCTCCTCTTTTGAAAAGGTAAGACCTCGTTTTAGTTGT

>In-frame_ENST00000353139_ENST00000419071_ERR315434_ACACA_chr17_35766352_-_PRPSAP2_chr17_18793135_length(amino acids)=179AA_start in transcript=987_stop in transcript=448
MELLDFMWNCIGDHHLINGRLFNPPGGVRRQQAMSCHHKDLICTSFLQGLCCSKKAVNIINDVIHDDGNPSSNITHNRDWGLFFRNQHGD

--------------------------------------------------------------
>In-frame_ENST00000353139_ENST00000268835_ERR315434_ACACA_chr17_35766352_-_PRPSAP2_chr17_18793135_length(transcript)=1619nt_BP=520nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGATCCCAGATTACAGGAATGC
AGTAATCGTGGCCAAGTCTCCAGCCTCGGCGAAGAGGGCACAGTCTTTTGCTGAGCGCCTGCGCCTGGGAATTGCAGTGATTCATGGAGA
GGCGCAGGATGCCGAGTCGGACTTGGTGGATGGACGGCATTCCCCACCCATGGTCAGAAGTGTGGCTGCCATCCACCCCAGCCTGGAGAT
CCCCATGCTGATTCCTAAAGAAAAGCCCCCAATCACGGTTGTGGGTGATGTTGGAGGAAGGATTGCCATCATCGTGGATGACATCATTGA
TGATGTTGACAGCTTTCTTGCTGCAGCAGAGACCCTGAAGGAAAGAGGTGCATATAAGATCTTTGTGATGGCAACTCATGGCTTGTTGTC
TTCTGACGCCCCCCGGCGGATTGAAGAGTCTGCCATTGATGAGGTGGTGGTCACCAATACAATTCCACATGAAGTCCAGAAGCTCCAGTG
CCCCAAGATTAAAACTGTGGATATCAGCATGATCCTTTCAGAGGCGATCCGTCGGATCCACAATGGGGAGTCCATGTCCTACCTTTTCAG
AAACATAGGCTTAGATGACTGAGTTTTCCTTTAGGAAAACTCCCGAGGGCCAAACTGGAAACATAAGAGTGACTGCTCGGTGGGATGGAT
TTCACAGGAACCGTCATGCTTGTTCCTCCCTCTCCCCTGTAACCTCACTTCTTATTGATTCCTAAGAAGATAGACCAACTTTTTATGTCG
GTTTGGGTGTTTGTGAGTTTGGGGAGCAATTTTTATAAAAGAAAAACTTTATTCTCCTCTTTTGAAAAGGTAAGACCTCGTTTTAGTTGT
AACTGTTTAAAAAATAACACTTGGAATAAGATTTGTAAGCTCACAAAGCCTTCTTCCAAAGTTGCTTGAGCCAAGTGCTTAAAAAGTTAA
TAAAATAAAATGATCTGTATGATACCTGCAATTGAAAAGCCGAAAAGATTATACTGTCAAGTCCAGTAAATGACATTTTTAGAGATGCTT

>In-frame_ENST00000353139_ENST00000268835_ERR315434_ACACA_chr17_35766352_-_PRPSAP2_chr17_18793135_length(amino acids)=179AA_start in transcript=987_stop in transcript=448
MELLDFMWNCIGDHHLINGRLFNPPGGVRRQQAMSCHHKDLICTSFLQGLCCSKKAVNIINDVIHDDGNPSSNITHNRDWGLFFRNQHGD

--------------------------------------------------------------
>In-frame_ENST00000353139_ENST00000536323_ERR315434_ACACA_chr17_35766352_-_PRPSAP2_chr17_18793135_length(transcript)=1428nt_BP=520nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGATCCCAGATTACAGGAATGC
AGTAATCGTGGCCAAGTCTCCAGCCTCGGCGAAGAGGGCACAGTCTTTTGCTGAGCGCCTGCGCCTGGGAATTGCAGTGATTCATGGAGA
GGCGCAGGATGCCGAGTCGGACTTGGTGGATGGACGGCATTCCCCACCCATGGTCAGAAGTGTGGCTGCCATCCACCCCAGCCTGGAGAT
CCCCATGCTGATTCCTAAAGAAAAGCCCCCAATCACGGTTGTGGGTGATGTTGGAGGAAGGATTGCCATCATCGTGGATGACATCATTGA
TGATGTTGACAGCTTTCTTGCTGCAGCAGAGACCCTGAAGGAAAGAGGTGCATATAAGATCTTTGTGATGGCAACTCATGGCTTGTTGTC
TTCTGACGCCCCCCGGCGGATTGAAGAGTCTGCCATTGATGAGGTGGTGGTCACCAATACAATTCCACATGAAGTCCAGAAGCTCCAGTG
CCCCAAGATTAAAACTGTGGATATCAGCATGATCCTTTCAGAGGCGATCCGTCGGATCCACAATGGGGAGTCCATGTCCTACCTTTTCAG
AAACATAGGCTTAGATGACTGAGTTTTCCTTTAGGAAAACTCCCGAGGGCCAAACTGGAAACATAAGAGTGACTGCTCGGTGGGATGGAT
TTCACAGGAACCGTCATGCTTGTTCCTCCCTCTCCCCTGTAACCTCACTTCTTATTGATTCCTAAGAAGATAGACCAACTTTTTATGTCG
GTTTGGGTGTTTGTGAGTTTGGGGAGCAATTTTTATAAAAGAAAAACTTTATTCTCCTCTTTTGAAAAGGTAAGACCTCGTTTTAGTTGT

>In-frame_ENST00000353139_ENST00000536323_ERR315434_ACACA_chr17_35766352_-_PRPSAP2_chr17_18793135_length(amino acids)=179AA_start in transcript=987_stop in transcript=448
MELLDFMWNCIGDHHLINGRLFNPPGGVRRQQAMSCHHKDLICTSFLQGLCCSKKAVNIINDVIHDDGNPSSNITHNRDWGLFFRNQHGD

--------------------------------------------------------------
>In-frame_ENST00000353139_ENST00000542013_ERR315434_ACACA_chr17_35766352_-_PRPSAP2_chr17_18793135_length(transcript)=991nt_BP=520nt
GCCCTCTTGGCCTTTTCCCGGTCCCCGCCGCGCGCCTGCTGCTGTCCCCGTGCCCGAGGACTGGGAGGATGGGGCTGAGCCGCTTGCCTG
ACTTTTGATCCGACCAGTAATCACTTTGCCCGTGTGGCGCGTGGCCCGTTGCCTGAGGCTTCCTGGCGCGTGGGGCTGTTTGGTCCCCTC
CGGAGTGCGGTGAGGCGGGCCGAGCCGGGACTGCCTGGGTTTGGGGATAACGTTCCCATCTCCACCCCTGTTGCAGCAAGGGAAATTGAG
GCTGAGGGAACTGGGCCCAGGGACGGCGAGCCGTGGCTGCCTCTCCAGTCCGGGCCCCGAAGGGCTGCTCGTGGATGAACCAGACTGATT
TTAAGGGGTGAAGAGGGTGCGTTTCAATCAGATGCTTCTGGAACGTCGAAATTGTCTTCTTTGGAAAGAACCATCCCCTCTTTGGGCTTC
AGAGGCCCAAATTGAGGCGCAATGATGAGAGGATGTGGTGGTCTACTCTGATGTCAATCTTGAGGGCTAGATCCCAGATTACAGGAATGC
AGTAATCGTGGCCAAGTCTCCAGCCTCGGCGAAGAGGGCACAGTCTTTTGCTGAGCGCCTGCGCCTGGGAATTGCAGTGATTCATGGAGA
GGCGCAGGATGCCGAGTCGGACTTGGTGGATGGACGGCATTCCCCACCCATGGTCAGAAGTGTGGCTGCCATCCACCCCAGCCTGGAGAT
CCCCATGCTGATTCCTAAAGAAAAGCCCCCAATCACGGTTGTGGGTGATGTTGGAGGAAGGATTGCCATCATCGTGGTGGTGGTCACCAA
TACAATTCCACATGAAGTCCAGAAGCTCCAGTGCCCCAAGATTAAAACTGTGGATATCAGCATGATCCTTTCAGAGGCGATCCGTCGGAT
CCACAATGGGGAGTCCATGTCCTACCTTTTCAGAAACATAGGCTTAGATGACTGAGTTTTCCTTTAGGAAAACTCCCGAGGGCCAAACTG

>In-frame_ENST00000353139_ENST00000542013_ERR315434_ACACA_chr17_35766352_-_PRPSAP2_chr17_18793135_length(amino acids)=130AA_start in transcript=840_stop in transcript=448
MELLDFMWNCIGDHHHDDGNPSSNITHNRDWGLFFRNQHGDLQAGVDGSHTSDHGWGMPSIHQVRLGILRLSMNHCNSQAQALSKRLCPL

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Fusion Gene PPI Analysis for ACACA-PRPSAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACACA-PRPSAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneACACAQ13085DB00121BiotinCofactorSmall moleculeApproved|Investigational|Nutraceutical
HgeneACACAQ13085DB00121BiotinCofactorSmall moleculeApproved|Investigational|Nutraceutical
HgeneACACAQ13085DB00121BiotinCofactorSmall moleculeApproved|Investigational|Nutraceutical
HgeneACACAQ13085DB00121BiotinCofactorSmall moleculeApproved|Investigational|Nutraceutical

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Related Diseases for ACACA-PRPSAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACACAC0018801Heart failure1CTD_human
HgeneACACAC0018802Congestive heart failure1CTD_human
HgeneACACAC0023212Left-Sided Heart Failure1CTD_human
HgeneACACAC0235527Heart Failure, Right-Sided1CTD_human
HgeneACACAC1959583Myocardial Failure1CTD_human
HgeneACACAC1961112Heart Decompensation1CTD_human
HgeneACACAC2239176Liver carcinoma1CTD_human