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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAPZA2-MET (FusionGDB2 ID:13032)

Fusion Gene Summary for CAPZA2-MET

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPZA2-MET
Fusion gene ID: 13032
HgeneTgene
Gene symbol

CAPZA2

MET

Gene ID

830

8731

Gene namecapping actin protein of muscle Z-line subunit alpha 2RNA guanine-7 methyltransferase
SynonymsCAPPA2|CAPZCMT1|CMT1c|MET|Met|RG7MT1|cm1p|hCMT1|hMet
Cytomap

7q31.2

18p11.21

Type of geneprotein-codingprotein-coding
DescriptionF-actin-capping protein subunit alpha-2F-actin capping protein alpha-2 subunitcapZ alpha-2capping actin protein of muscle Z-line alpha subunit 2capping protein (actin filament) muscle Z-line, alpha 2epididymis secretory sperm binding proteinmRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase
Modification date2020031320200329
UniProtAcc.

Q9H1A3

Ensembl transtripts involved in fusion geneENST00000361183, ENST00000458284, 
ENST00000490693, ENST00000466023, 
ENST00000397752, ENST00000318493, 
ENST00000436117, ENST00000495962, 
ENST00000539704, 
Fusion gene scores* DoF score17 X 6 X 9=91814 X 18 X 10=2520
# samples 2027
** MAII scorelog2(20/918*10)=-2.19849415363908
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2520*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPZA2 [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract]

Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer (pmid: 28512244)
Most frequent breakpointCAPZA2(116550365)-MET(116409699), # samples:2
CAPZA2(116528244)-MET(116395409), # samples:2
CAPZA2(116528244)-MET(116414935), # samples:2
MET(116399544)-CAPZA2(116528181), # samples:2
Anticipated loss of major functional domain due to fusion event.CAPZA2-MET seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CAPZA2-MET seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
CAPZA2-MET seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CAPZA2-MET seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMET

GO:0006370

7-methylguanosine mRNA capping

27422871


check buttonFusion gene breakpoints across CAPZA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A1AN-01ACAPZA2chr7

116550365

+METchr7

116409699

+
ChimerDB4KIRPTCGA-G7-6793CAPZA2chr7

116528244

+METchr7

116395409

+
ChimerDB4LUADTCGA-78-7220-01ACAPZA2chr7

116528244

+METchr7

116414935

+
ChimerDB4STADTCGA-HU-8238-01ACAPZA2chr7

116502704

+METchr7

116435709

+
ChimerDB4LUADTCGA-78-7220-01ACAPZA2chr7

116528244

-METchr7

116414935

+
ChimerDB4BRCATCGA-AR-A1AN-01ACAPZA2chr7

116550365

-METchr7

116409699

+
ChimerDB4KIRPTCGA-G7-6793-01ACAPZA2chr7

116528244

-METchr7

116395409

+


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Fusion Gene ORF analysis for CAPZA2-MET

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000361183ENST00000397752CAPZA2chr7

116550365

+METchr7

116409699

+
In-frameENST00000361183ENST00000318493CAPZA2chr7

116550365

+METchr7

116409699

+
5CDS-intronENST00000361183ENST00000436117CAPZA2chr7

116550365

+METchr7

116409699

+
5CDS-intronENST00000361183ENST00000495962CAPZA2chr7

116550365

+METchr7

116409699

+
5CDS-intronENST00000361183ENST00000539704CAPZA2chr7

116550365

+METchr7

116409699

+
Frame-shiftENST00000458284ENST00000397752CAPZA2chr7

116550365

+METchr7

116409699

+
Frame-shiftENST00000458284ENST00000318493CAPZA2chr7

116550365

+METchr7

116409699

+
5CDS-intronENST00000458284ENST00000436117CAPZA2chr7

116550365

+METchr7

116409699

+
5CDS-intronENST00000458284ENST00000495962CAPZA2chr7

116550365

+METchr7

116409699

+
5CDS-intronENST00000458284ENST00000539704CAPZA2chr7

116550365

+METchr7

116409699

+
intron-3CDSENST00000490693ENST00000397752CAPZA2chr7

116550365

+METchr7

116409699

+
intron-3CDSENST00000490693ENST00000318493CAPZA2chr7

116550365

+METchr7

116409699

+
intron-intronENST00000490693ENST00000436117CAPZA2chr7

116550365

+METchr7

116409699

+
intron-intronENST00000490693ENST00000495962CAPZA2chr7

116550365

+METchr7

116409699

+
intron-intronENST00000490693ENST00000539704CAPZA2chr7

116550365

+METchr7

116409699

+
intron-3CDSENST00000466023ENST00000397752CAPZA2chr7

116550365

+METchr7

116409699

+
intron-3CDSENST00000466023ENST00000318493CAPZA2chr7

116550365

+METchr7

116409699

+
intron-intronENST00000466023ENST00000436117CAPZA2chr7

116550365

+METchr7

116409699

+
intron-intronENST00000466023ENST00000495962CAPZA2chr7

116550365

+METchr7

116409699

+
intron-intronENST00000466023ENST00000539704CAPZA2chr7

116550365

+METchr7

116409699

+
Frame-shiftENST00000361183ENST00000397752CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000361183ENST00000318493CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000361183ENST00000436117CAPZA2chr7

116528244

+METchr7

116395409

+
5CDS-3UTRENST00000361183ENST00000495962CAPZA2chr7

116528244

+METchr7

116395409

+
5CDS-intronENST00000361183ENST00000539704CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000458284ENST00000397752CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000458284ENST00000318493CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000458284ENST00000436117CAPZA2chr7

116528244

+METchr7

116395409

+
5CDS-3UTRENST00000458284ENST00000495962CAPZA2chr7

116528244

+METchr7

116395409

+
5CDS-intronENST00000458284ENST00000539704CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000490693ENST00000397752CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000490693ENST00000318493CAPZA2chr7

116528244

+METchr7

116395409

+
Frame-shiftENST00000490693ENST00000436117CAPZA2chr7

116528244

+METchr7

116395409

+
5CDS-3UTRENST00000490693ENST00000495962CAPZA2chr7

116528244

+METchr7

116395409

+
5CDS-intronENST00000490693ENST00000539704CAPZA2chr7

116528244

+METchr7

116395409

+
intron-3CDSENST00000466023ENST00000397752CAPZA2chr7

116528244

+METchr7

116395409

+
intron-3CDSENST00000466023ENST00000318493CAPZA2chr7

116528244

+METchr7

116395409

+
intron-3CDSENST00000466023ENST00000436117CAPZA2chr7

116528244

+METchr7

116395409

+
intron-3UTRENST00000466023ENST00000495962CAPZA2chr7

116528244

+METchr7

116395409

+
intron-intronENST00000466023ENST00000539704CAPZA2chr7

116528244

+METchr7

116395409

+
In-frameENST00000361183ENST00000397752CAPZA2chr7

116528244

+METchr7

116414935

+
In-frameENST00000361183ENST00000318493CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000361183ENST00000436117CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000361183ENST00000495962CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000361183ENST00000539704CAPZA2chr7

116528244

+METchr7

116414935

+
In-frameENST00000458284ENST00000397752CAPZA2chr7

116528244

+METchr7

116414935

+
In-frameENST00000458284ENST00000318493CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000458284ENST00000436117CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000458284ENST00000495962CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000458284ENST00000539704CAPZA2chr7

116528244

+METchr7

116414935

+
In-frameENST00000490693ENST00000397752CAPZA2chr7

116528244

+METchr7

116414935

+
In-frameENST00000490693ENST00000318493CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000490693ENST00000436117CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000490693ENST00000495962CAPZA2chr7

116528244

+METchr7

116414935

+
5CDS-intronENST00000490693ENST00000539704CAPZA2chr7

116528244

+METchr7

116414935

+
intron-3CDSENST00000466023ENST00000397752CAPZA2chr7

116528244

+METchr7

116414935

+
intron-3CDSENST00000466023ENST00000318493CAPZA2chr7

116528244

+METchr7

116414935

+
intron-intronENST00000466023ENST00000436117CAPZA2chr7

116528244

+METchr7

116414935

+
intron-intronENST00000466023ENST00000495962CAPZA2chr7

116528244

+METchr7

116414935

+
intron-intronENST00000466023ENST00000539704CAPZA2chr7

116528244

+METchr7

116414935

+
In-frameENST00000361183ENST00000397752CAPZA2chr7

116502704

+METchr7

116435709

+
In-frameENST00000361183ENST00000318493CAPZA2chr7

116502704

+METchr7

116435709

+
5CDS-intronENST00000361183ENST00000436117CAPZA2chr7

116502704

+METchr7

116435709

+
5CDS-intronENST00000361183ENST00000495962CAPZA2chr7

116502704

+METchr7

116435709

+
5CDS-intronENST00000361183ENST00000539704CAPZA2chr7

116502704

+METchr7

116435709

+
In-frameENST00000458284ENST00000397752CAPZA2chr7

116502704

+METchr7

116435709

+
In-frameENST00000458284ENST00000318493CAPZA2chr7

116502704

+METchr7

116435709

+
5CDS-intronENST00000458284ENST00000436117CAPZA2chr7

116502704

+METchr7

116435709

+
5CDS-intronENST00000458284ENST00000495962CAPZA2chr7

116502704

+METchr7

116435709

+
5CDS-intronENST00000458284ENST00000539704CAPZA2chr7

116502704

+METchr7

116435709

+
In-frameENST00000490693ENST00000397752CAPZA2chr7

116502704

+METchr7

116435709

+
In-frameENST00000490693ENST00000318493CAPZA2chr7

116502704

+METchr7

116435709

+
5CDS-intronENST00000490693ENST00000436117CAPZA2chr7

116502704

+METchr7

116435709

+
5CDS-intronENST00000490693ENST00000495962CAPZA2chr7

116502704

+METchr7

116435709

+
5CDS-intronENST00000490693ENST00000539704CAPZA2chr7

116502704

+METchr7

116435709

+
3UTR-3CDSENST00000466023ENST00000397752CAPZA2chr7

116502704

+METchr7

116435709

+
3UTR-3CDSENST00000466023ENST00000318493CAPZA2chr7

116502704

+METchr7

116435709

+
3UTR-intronENST00000466023ENST00000436117CAPZA2chr7

116502704

+METchr7

116435709

+
3UTR-intronENST00000466023ENST00000495962CAPZA2chr7

116502704

+METchr7

116435709

+
3UTR-intronENST00000466023ENST00000539704CAPZA2chr7

116502704

+METchr7

116435709

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361183CAPZA2chr7116550365+ENST00000397752METchr7116409699+45767241002313737
ENST00000361183CAPZA2chr7116550365+ENST00000318493METchr7116409699+25327241002313737
ENST00000361183CAPZA2chr7116528244+ENST00000397752METchr7116414935+36492421001386428
ENST00000361183CAPZA2chr7116528244+ENST00000318493METchr7116414935+16052421001386428
ENST00000458284CAPZA2chr7116528244+ENST00000397752METchr7116414935+3563156141300428
ENST00000458284CAPZA2chr7116528244+ENST00000318493METchr7116414935+1519156141300428
ENST00000490693CAPZA2chr7116528244+ENST00000397752METchr7116414935+3522115121259415
ENST00000490693CAPZA2chr7116528244+ENST00000318493METchr7116414935+1478115121259415

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361183ENST00000397752CAPZA2chr7116550365+METchr7116409699+0.0004711910.9995289
ENST00000361183ENST00000318493CAPZA2chr7116550365+METchr7116409699+0.0012178890.9987821
ENST00000361183ENST00000397752CAPZA2chr7116528244+METchr7116414935+0.0003189090.9996811
ENST00000361183ENST00000318493CAPZA2chr7116528244+METchr7116414935+0.0006527510.99934727
ENST00000458284ENST00000397752CAPZA2chr7116528244+METchr7116414935+0.0003160450.999684
ENST00000458284ENST00000318493CAPZA2chr7116528244+METchr7116414935+0.0005756890.99942434
ENST00000490693ENST00000397752CAPZA2chr7116528244+METchr7116414935+0.0003022740.9996978
ENST00000490693ENST00000318493CAPZA2chr7116528244+METchr7116414935+0.0005895970.9994104

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Fusion Genomic Features for CAPZA2-MET


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CAPZA2chr7116528244+METchr7116414934+6.06E-060.9999939
CAPZA2chr7116528244+METchr7116395408+1.50E-060.99999845
CAPZA2chr7116502704+METchr7116435708+7.05E-070.9999993
CAPZA2chr7116550365+METchr7116409698+6.81E-080.9999999
CAPZA2chr7116528244+METchr7116414934+6.06E-060.9999939
CAPZA2chr7116528244+METchr7116395408+1.50E-060.99999845
CAPZA2chr7116502704+METchr7116435708+7.05E-070.9999993
CAPZA2chr7116550365+METchr7116409698+6.81E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CAPZA2-MET


check button Go to

FGviewer for the breakpoints of chr7:116550365-chr7:116409699

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MET

Q9H1A3

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMETchr7:116502704chr7:116435709ENST00000436117091078_13450.0765.0DomainProtein kinase
TgeneMETchr7:116502704chr7:116435709ENST000004361170927_5150.0765.0DomainSema
TgeneMETchr7:116502704chr7:116435709ENST0000043611709563_6550.0765.0DomainNote=IPT/TIG 1
TgeneMETchr7:116502704chr7:116435709ENST0000043611709657_7390.0765.0DomainNote=IPT/TIG 2
TgeneMETchr7:116502704chr7:116435709ENST0000043611709742_8360.0765.0DomainNote=IPT/TIG 3
TgeneMETchr7:116528244chr7:116414935ENST0000031849313211078_13451027.33333333333331409.0DomainProtein kinase
TgeneMETchr7:116528244chr7:116414935ENST0000039775213211078_13451009.33333333333341391.0DomainProtein kinase
TgeneMETchr7:116528244chr7:116414935ENST00000436117091078_13450.0765.0DomainProtein kinase
TgeneMETchr7:116528244chr7:116414935ENST000004361170927_5150.0765.0DomainSema
TgeneMETchr7:116528244chr7:116414935ENST0000043611709563_6550.0765.0DomainNote=IPT/TIG 1
TgeneMETchr7:116528244chr7:116414935ENST0000043611709657_7390.0765.0DomainNote=IPT/TIG 2
TgeneMETchr7:116528244chr7:116414935ENST0000043611709742_8360.0765.0DomainNote=IPT/TIG 3
TgeneMETchr7:116550365chr7:116409699ENST0000031849310211078_1345879.01409.0DomainProtein kinase
TgeneMETchr7:116550365chr7:116409699ENST0000039775210211078_1345861.01391.0DomainProtein kinase
TgeneMETchr7:116550365chr7:116409699ENST00000436117091078_13450.0765.0DomainProtein kinase
TgeneMETchr7:116550365chr7:116409699ENST000004361170927_5150.0765.0DomainSema
TgeneMETchr7:116550365chr7:116409699ENST0000043611709563_6550.0765.0DomainNote=IPT/TIG 1
TgeneMETchr7:116550365chr7:116409699ENST0000043611709657_7390.0765.0DomainNote=IPT/TIG 2
TgeneMETchr7:116550365chr7:116409699ENST0000043611709742_8360.0765.0DomainNote=IPT/TIG 3
TgeneMETchr7:116502704chr7:116435709ENST00000436117091084_10920.0765.0Nucleotide bindingATP
TgeneMETchr7:116528244chr7:116414935ENST0000031849313211084_10921027.33333333333331409.0Nucleotide bindingATP
TgeneMETchr7:116528244chr7:116414935ENST0000039775213211084_10921009.33333333333341391.0Nucleotide bindingATP
TgeneMETchr7:116528244chr7:116414935ENST00000436117091084_10920.0765.0Nucleotide bindingATP
TgeneMETchr7:116550365chr7:116409699ENST0000031849310211084_1092879.01409.0Nucleotide bindingATP
TgeneMETchr7:116550365chr7:116409699ENST0000039775210211084_1092861.01391.0Nucleotide bindingATP
TgeneMETchr7:116550365chr7:116409699ENST00000436117091084_10920.0765.0Nucleotide bindingATP
TgeneMETchr7:116502704chr7:116435709ENST000004361170925_9320.0765.0Topological domainExtracellular
TgeneMETchr7:116502704chr7:116435709ENST0000043611709956_13900.0765.0Topological domainCytoplasmic
TgeneMETchr7:116528244chr7:116414935ENST000004361170925_9320.0765.0Topological domainExtracellular
TgeneMETchr7:116528244chr7:116414935ENST0000043611709956_13900.0765.0Topological domainCytoplasmic
TgeneMETchr7:116550365chr7:116409699ENST000003184931021956_1390879.01409.0Topological domainCytoplasmic
TgeneMETchr7:116550365chr7:116409699ENST000003977521021956_1390861.01391.0Topological domainCytoplasmic
TgeneMETchr7:116550365chr7:116409699ENST000004361170925_9320.0765.0Topological domainExtracellular
TgeneMETchr7:116550365chr7:116409699ENST0000043611709956_13900.0765.0Topological domainCytoplasmic
TgeneMETchr7:116502704chr7:116435709ENST0000043611709933_9550.0765.0TransmembraneHelical
TgeneMETchr7:116528244chr7:116414935ENST0000043611709933_9550.0765.0TransmembraneHelical
TgeneMETchr7:116550365chr7:116409699ENST000003184931021933_955879.01409.0TransmembraneHelical
TgeneMETchr7:116550365chr7:116409699ENST000003977521021933_955861.01391.0TransmembraneHelical
TgeneMETchr7:116550365chr7:116409699ENST0000043611709933_9550.0765.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMETchr7:116502704chr7:116435709ENST0000031849318211078_13451284.01409.0DomainProtein kinase
TgeneMETchr7:116502704chr7:116435709ENST00000318493182127_5151284.01409.0DomainSema
TgeneMETchr7:116502704chr7:116435709ENST000003184931821563_6551284.01409.0DomainNote=IPT/TIG 1
TgeneMETchr7:116502704chr7:116435709ENST000003184931821657_7391284.01409.0DomainNote=IPT/TIG 2
TgeneMETchr7:116502704chr7:116435709ENST000003184931821742_8361284.01409.0DomainNote=IPT/TIG 3
TgeneMETchr7:116502704chr7:116435709ENST0000039775218211078_13451266.01391.0DomainProtein kinase
TgeneMETchr7:116502704chr7:116435709ENST00000397752182127_5151266.01391.0DomainSema
TgeneMETchr7:116502704chr7:116435709ENST000003977521821563_6551266.01391.0DomainNote=IPT/TIG 1
TgeneMETchr7:116502704chr7:116435709ENST000003977521821657_7391266.01391.0DomainNote=IPT/TIG 2
TgeneMETchr7:116502704chr7:116435709ENST000003977521821742_8361266.01391.0DomainNote=IPT/TIG 3
TgeneMETchr7:116528244chr7:116414935ENST00000318493132127_5151027.33333333333331409.0DomainSema
TgeneMETchr7:116528244chr7:116414935ENST000003184931321563_6551027.33333333333331409.0DomainNote=IPT/TIG 1
TgeneMETchr7:116528244chr7:116414935ENST000003184931321657_7391027.33333333333331409.0DomainNote=IPT/TIG 2
TgeneMETchr7:116528244chr7:116414935ENST000003184931321742_8361027.33333333333331409.0DomainNote=IPT/TIG 3
TgeneMETchr7:116528244chr7:116414935ENST00000397752132127_5151009.33333333333341391.0DomainSema
TgeneMETchr7:116528244chr7:116414935ENST000003977521321563_6551009.33333333333341391.0DomainNote=IPT/TIG 1
TgeneMETchr7:116528244chr7:116414935ENST000003977521321657_7391009.33333333333341391.0DomainNote=IPT/TIG 2
TgeneMETchr7:116528244chr7:116414935ENST000003977521321742_8361009.33333333333341391.0DomainNote=IPT/TIG 3
TgeneMETchr7:116550365chr7:116409699ENST00000318493102127_515879.01409.0DomainSema
TgeneMETchr7:116550365chr7:116409699ENST000003184931021563_655879.01409.0DomainNote=IPT/TIG 1
TgeneMETchr7:116550365chr7:116409699ENST000003184931021657_739879.01409.0DomainNote=IPT/TIG 2
TgeneMETchr7:116550365chr7:116409699ENST000003184931021742_836879.01409.0DomainNote=IPT/TIG 3
TgeneMETchr7:116550365chr7:116409699ENST00000397752102127_515861.01391.0DomainSema
TgeneMETchr7:116550365chr7:116409699ENST000003977521021563_655861.01391.0DomainNote=IPT/TIG 1
TgeneMETchr7:116550365chr7:116409699ENST000003977521021657_739861.01391.0DomainNote=IPT/TIG 2
TgeneMETchr7:116550365chr7:116409699ENST000003977521021742_836861.01391.0DomainNote=IPT/TIG 3
TgeneMETchr7:116502704chr7:116435709ENST0000031849318211084_10921284.01409.0Nucleotide bindingATP
TgeneMETchr7:116502704chr7:116435709ENST0000039775218211084_10921266.01391.0Nucleotide bindingATP
TgeneMETchr7:116502704chr7:116435709ENST00000318493182125_9321284.01409.0Topological domainExtracellular
TgeneMETchr7:116502704chr7:116435709ENST000003184931821956_13901284.01409.0Topological domainCytoplasmic
TgeneMETchr7:116502704chr7:116435709ENST00000397752182125_9321266.01391.0Topological domainExtracellular
TgeneMETchr7:116502704chr7:116435709ENST000003977521821956_13901266.01391.0Topological domainCytoplasmic
TgeneMETchr7:116528244chr7:116414935ENST00000318493132125_9321027.33333333333331409.0Topological domainExtracellular
TgeneMETchr7:116528244chr7:116414935ENST000003184931321956_13901027.33333333333331409.0Topological domainCytoplasmic
TgeneMETchr7:116528244chr7:116414935ENST00000397752132125_9321009.33333333333341391.0Topological domainExtracellular
TgeneMETchr7:116528244chr7:116414935ENST000003977521321956_13901009.33333333333341391.0Topological domainCytoplasmic
TgeneMETchr7:116550365chr7:116409699ENST00000318493102125_932879.01409.0Topological domainExtracellular
TgeneMETchr7:116550365chr7:116409699ENST00000397752102125_932861.01391.0Topological domainExtracellular
TgeneMETchr7:116502704chr7:116435709ENST000003184931821933_9551284.01409.0TransmembraneHelical
TgeneMETchr7:116502704chr7:116435709ENST000003977521821933_9551266.01391.0TransmembraneHelical
TgeneMETchr7:116528244chr7:116414935ENST000003184931321933_9551027.33333333333331409.0TransmembraneHelical
TgeneMETchr7:116528244chr7:116414935ENST000003977521321933_9551009.33333333333341391.0TransmembraneHelical


Top

Fusion Gene Sequence for CAPZA2-MET


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000361183_ENST00000397752_TCGA-AR-A1AN-01A_CAPZA2_chr7_116550365_+_MET_chr7_116409699_length(transcript)=4576nt_BP=724nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGT
GCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTTCGGTTACTGCTTAATAATGACAA
TCTTCTCAGGGAAGGAGCAGCCCATGCATTTGCACAGTATAACTTGGACCAGTTTACTCCAGTAAAAATTGAAGGTTATGAAGATCAGGT
ATTGATAACAGAACATGGCGACTTGGGAAATGGAAAGTTTTTGGATCCAAAGAACAGAATCTGTTTTAAATTTGATCACTTAAGGAAGGA
GGCAACTGATCCAAGACCCTGTGAAGTAGAAAATGCAGTTGAATCATGGAGAACTTCAGTAGAAACTGCTCTGAGAGCTTACGTAAAAGA
ACATTACCCGAATGGAGTCTGCACTGTGTATGGCAAAAAAATAGATGGACAGCAAACCATTATTGCATGCATAGAAAGCCATCAGTTCCA
AGCAAAAAATTTTTGGAATGGTCGTTGGAGGTCAGAATGGAAGTTTACAATCACTCCTTCAACCACTCAAGTGGTTGGCATCTTGAAAAT
TCAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGA
AGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCT
TGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGG
GTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTT
GGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGA
TCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTC
TGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGT
GATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAA
TGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCAT
CATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACAT
GAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAA
AGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGT
TGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGAT
GGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGG
AGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGA
CCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGAT
CTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTC
ATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGT
CCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGAC
TTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCACGGACC
AATGGCCTGCAGCCGTGACAACACTCCTGTCATATTGGAGTCCAAAACTTGAATTCTGGGTTGAATTTTTTAAAAATCAGGTACCACTTG
ATTTCATATGGGAAATTGAAGCAGGAAATATTGAGGGCTTCTTGATCACAGAAAACTCAGAAGAGATAGTAATGCTCAGGACAGGAGCGG
CAGCCCCAGAACAGGCCACTCATTTAGAATTCTAGTGTTTCAAAACACTTTTGTGTGTTGTATGGTCAATAACATTTTTCATTACTGATG
GTGTCATTCACCCATTAGGTAAACATTCCCTTTTAAATGTTTGTTTGTTTTTTGAGACAGGATCTCACTCTGTTGCCAGGGCTGTAGTGC
AGTGGTGTGATCATAGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCCTCCCGAATAGCTGGGACTACAGGCGCACACCACCATCCCCG
GCTAATTTTTGTATTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCAAGGCTGGTTTCAAACTCCTGGACTCAAGAAATCCACCCACCTC
AGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACTGCGCCCAGCCCTTATAAATTTTTGTATAGACATTCCTTTGGTTGGAAGAATA
TTTATAGGCAATACAGTCAAAGTTTCAAAATAGCATCACACAAAACATGTTTATAAATGAACAGGATGTAATGTACATAGATGACATTAA
GAAAATTTGTATGAAATAATTTAGTCATCATGAAATATTTAGTTGTCATATAAAAACCCACTGTTTGAGAATGATGCTACTCTGATCTAA
TGAATGTGAACATGTAGATGTTTTGTGTGTATTTTTTTAAATGAAAACTCAAAATAAGACAAGTAATTTGTTGATAAATATTTTTAAAGA
TAACTCAGCATGTTTGTAAAGCAGGATACATTTTACTAAAAGGTTCATTGGTTCCAATCACAGCTCATAGGTAGAGCAAAGAAAGGGTGG
ATGGATTGAAAAGATTAGCCTCTGTCTCGGTGGCAGGTTCCCACCTCGCAAGCAATTGGAAACAAAACTTTTGGGGAGTTTTATTTTGCA
TTAGGGTGTGTTTTATGTTAAGCAAAACATACTTTAGAAACAAATGAAAAAGGCAATTGAAAATCCCAGCTATTTCACCTAGATGGAATA
GCCACCCTGAGCAGAACTTTGTGATGCTTCATTCTGTGGAATTTTGTGCTTGCTACTGTATAGTGCATGTGGTGTAGGTTACTCTAACTG
GTTTTGTCGACGTAAACATTTAAAGTGTTATATTTTTTATAAAAATGTTTATTTTTAATGATATGAGAAAAATTTTGTTAGGCCACAAAA
ACACTGCACTGTGAACATTTTAGAAAAGGTATGTCAGACTGGGATTAATGACAGCATGATTTTCAATGACTGTAAATTGCGATAAGGAAA
TGTACTGATTGCCAATACACCCCACCCTCATTACATCATCAGGACTTGAAGCCAAGGGTTAACCCAGCAAGCTACAAAGAGGGTGTGTCA
CACTGAAACTCAATAGTTGAGTTTGGCTGTTGTTGCAGGAAAATGATTATAACTAAAAGCTCTCTGATAGTGCAGAGACTTACCAGAAGA
CACAAGGAATTGTACTGAAGAGCTATTACAATCCAAATATTGCCGTTTCATAAATGTAATAAGTAATACTAATTCACAGAGTATTGTAAA
TGGTGGATGACAAAAGAAAATCTGCTCTGTGGAAAGAAAGAACTGTCTCTACCAGGGTCAAGAGCATGAACGCATCAATAGAAAGAACTC
GGGGAAACATCCCATCAACAGGACTACACACTTGTATATACATTCTTGAGAACACTGCAATGTGAAAATCACGTTTGCTATTTATAAACT
TGTCCTTAGATTAATGTGTCTGGACAGATTGTGGGAGTAAGTGATTCTTCTAAGAATTAGATACTTGTCACTGCCTATACCTGCAGCTGA

>In-frame_ENST00000361183_ENST00000397752_TCGA-AR-A1AN-01A_CAPZA2_chr7_116550365_+_MET_chr7_116409699_length(amino acids)=737AA_start in transcript=100_stop in transcript=2313
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLIT
EHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKN
FWNGRWRSEWKFTITPSTTQVVGILKIQGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKV
IVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFP
NSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGK
KIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMK
YLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPP
YPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSED

--------------------------------------------------------------
>In-frame_ENST00000361183_ENST00000318493_TCGA-AR-A1AN-01A_CAPZA2_chr7_116550365_+_MET_chr7_116409699_length(transcript)=2532nt_BP=724nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGT
GCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTTCGGTTACTGCTTAATAATGACAA
TCTTCTCAGGGAAGGAGCAGCCCATGCATTTGCACAGTATAACTTGGACCAGTTTACTCCAGTAAAAATTGAAGGTTATGAAGATCAGGT
ATTGATAACAGAACATGGCGACTTGGGAAATGGAAAGTTTTTGGATCCAAAGAACAGAATCTGTTTTAAATTTGATCACTTAAGGAAGGA
GGCAACTGATCCAAGACCCTGTGAAGTAGAAAATGCAGTTGAATCATGGAGAACTTCAGTAGAAACTGCTCTGAGAGCTTACGTAAAAGA
ACATTACCCGAATGGAGTCTGCACTGTGTATGGCAAAAAAATAGATGGACAGCAAACCATTATTGCATGCATAGAAAGCCATCAGTTCCA
AGCAAAAAATTTTTGGAATGGTCGTTGGAGGTCAGAATGGAAGTTTACAATCACTCCTTCAACCACTCAAGTGGTTGGCATCTTGAAAAT
TCAGGGAAATGATATTGACCCTGAAGCAGTTAAAGGTGAAGTGTTAAAAGTTGGAAATAAGAGCTGTGAGAATATACACTTACATTCTGA
AGCCGTTTTATGCACGGTCCCCAATGACCTGCTGAAATTGAACAGCGAGCTAAATATAGAGTGGAAGCAAGCAATTTCTTCAACCGTCCT
TGGAAAAGTAATAGTTCAACCAGATCAGAATTTCACAGGATTGATTGCTGGTGTTGTCTCAATATCAACAGCACTGTTATTACTACTTGG
GTTTTTCCTGTGGCTGAAAAAGAGAAAGCAAATTAAAGATCTGGGCAGTGAATTAGTTCGCTACGATGCAAGAGTACACACTCCTCATTT
GGATAGGCTTGTAAGTGCCCGAAGTGTAAGCCCAACTACAGAAATGGTTTCAAATGAATCTGTAGACTACCGAGCTACTTTTCCAGAAGA
TCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTC
TGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGT
GATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAA
TGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCAT
CATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACAT
GAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAA
AGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGT
TGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGAT
GGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGG
AGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGA
CCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGAT
CTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTC
ATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGT
CCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGAC
TTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCACGGACC

>In-frame_ENST00000361183_ENST00000318493_TCGA-AR-A1AN-01A_CAPZA2_chr7_116550365_+_MET_chr7_116409699_length(amino acids)=737AA_start in transcript=100_stop in transcript=2313
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLIT
EHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKN
FWNGRWRSEWKFTITPSTTQVVGILKIQGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKV
IVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFP
NSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGK
KIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMK
YLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPP
YPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSED

--------------------------------------------------------------
>In-frame_ENST00000361183_ENST00000397752_TCGA-78-7220-01A_CAPZA2_chr7_116528244_+_MET_chr7_116414935_length(transcript)=3649nt_BP=242nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGT
GCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGG
TTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAA
TACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCA
TTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGT
GAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGT
CCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCAT
TCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAA
GTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACAT
GTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAA
GTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACAC
CTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATG
CTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTA
TGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGT
GGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTTTCAC
TGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTGGATT
CTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCACGGACCAATGGCCTGCAGCCGTGACAACACTCC
TGTCATATTGGAGTCCAAAACTTGAATTCTGGGTTGAATTTTTTAAAAATCAGGTACCACTTGATTTCATATGGGAAATTGAAGCAGGAA
ATATTGAGGGCTTCTTGATCACAGAAAACTCAGAAGAGATAGTAATGCTCAGGACAGGAGCGGCAGCCCCAGAACAGGCCACTCATTTAG
AATTCTAGTGTTTCAAAACACTTTTGTGTGTTGTATGGTCAATAACATTTTTCATTACTGATGGTGTCATTCACCCATTAGGTAAACATT
CCCTTTTAAATGTTTGTTTGTTTTTTGAGACAGGATCTCACTCTGTTGCCAGGGCTGTAGTGCAGTGGTGTGATCATAGCTCACTGCAAC
CTCCACCTCCCAGGCTCAAGCCTCCCGAATAGCTGGGACTACAGGCGCACACCACCATCCCCGGCTAATTTTTGTATTTTTTGTAGAGAC
GGGGTTTTGCCATGTTGCCAAGGCTGGTTTCAAACTCCTGGACTCAAGAAATCCACCCACCTCAGCCTCCCAAAGTGCTAGGATTACAGG
CATGAGCCACTGCGCCCAGCCCTTATAAATTTTTGTATAGACATTCCTTTGGTTGGAAGAATATTTATAGGCAATACAGTCAAAGTTTCA
AAATAGCATCACACAAAACATGTTTATAAATGAACAGGATGTAATGTACATAGATGACATTAAGAAAATTTGTATGAAATAATTTAGTCA
TCATGAAATATTTAGTTGTCATATAAAAACCCACTGTTTGAGAATGATGCTACTCTGATCTAATGAATGTGAACATGTAGATGTTTTGTG
TGTATTTTTTTAAATGAAAACTCAAAATAAGACAAGTAATTTGTTGATAAATATTTTTAAAGATAACTCAGCATGTTTGTAAAGCAGGAT
ACATTTTACTAAAAGGTTCATTGGTTCCAATCACAGCTCATAGGTAGAGCAAAGAAAGGGTGGATGGATTGAAAAGATTAGCCTCTGTCT
CGGTGGCAGGTTCCCACCTCGCAAGCAATTGGAAACAAAACTTTTGGGGAGTTTTATTTTGCATTAGGGTGTGTTTTATGTTAAGCAAAA
CATACTTTAGAAACAAATGAAAAAGGCAATTGAAAATCCCAGCTATTTCACCTAGATGGAATAGCCACCCTGAGCAGAACTTTGTGATGC
TTCATTCTGTGGAATTTTGTGCTTGCTACTGTATAGTGCATGTGGTGTAGGTTACTCTAACTGGTTTTGTCGACGTAAACATTTAAAGTG
TTATATTTTTTATAAAAATGTTTATTTTTAATGATATGAGAAAAATTTTGTTAGGCCACAAAAACACTGCACTGTGAACATTTTAGAAAA
GGTATGTCAGACTGGGATTAATGACAGCATGATTTTCAATGACTGTAAATTGCGATAAGGAAATGTACTGATTGCCAATACACCCCACCC
TCATTACATCATCAGGACTTGAAGCCAAGGGTTAACCCAGCAAGCTACAAAGAGGGTGTGTCACACTGAAACTCAATAGTTGAGTTTGGC
TGTTGTTGCAGGAAAATGATTATAACTAAAAGCTCTCTGATAGTGCAGAGACTTACCAGAAGACACAAGGAATTGTACTGAAGAGCTATT
ACAATCCAAATATTGCCGTTTCATAAATGTAATAAGTAATACTAATTCACAGAGTATTGTAAATGGTGGATGACAAAAGAAAATCTGCTC
TGTGGAAAGAAAGAACTGTCTCTACCAGGGTCAAGAGCATGAACGCATCAATAGAAAGAACTCGGGGAAACATCCCATCAACAGGACTAC
ACACTTGTATATACATTCTTGAGAACACTGCAATGTGAAAATCACGTTTGCTATTTATAAACTTGTCCTTAGATTAATGTGTCTGGACAG
ATTGTGGGAGTAAGTGATTCTTCTAAGAATTAGATACTTGTCACTGCCTATACCTGCAGCTGAACTGAATGGTACTTCGTATGTTAATAG

>In-frame_ENST00000361183_ENST00000397752_TCGA-78-7220-01A_CAPZA2_chr7_116528244_+_MET_chr7_116414935_length(amino acids)=428AA_start in transcript=100_stop in transcript=1386
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVH
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL
LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDK
EYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP

--------------------------------------------------------------
>In-frame_ENST00000361183_ENST00000318493_TCGA-78-7220-01A_CAPZA2_chr7_116528244_+_MET_chr7_116414935_length(transcript)=1605nt_BP=242nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGT
GCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGG
TTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAA
TACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCA
TTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGT
GAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGT
CCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCAT
TCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAA
GTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACAT
GTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAA
GTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACAC
CTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATG
CTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTA
TGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGT
GGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTTTCAC
TGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTGGATT

>In-frame_ENST00000361183_ENST00000318493_TCGA-78-7220-01A_CAPZA2_chr7_116528244_+_MET_chr7_116414935_length(amino acids)=428AA_start in transcript=100_stop in transcript=1386
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVH
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL
LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDK
EYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP

--------------------------------------------------------------
>In-frame_ENST00000458284_ENST00000397752_TCGA-78-7220-01A_CAPZA2_chr7_116528244_+_MET_chr7_116414935_length(transcript)=3563nt_BP=156nt
AAGTCAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGA
AGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGA
ACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGC
AAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTG
TGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTG
CTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCA
ATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATT
TCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCA
AAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAG
ACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTC
AAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAA
ACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAA
AATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGC
ACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATG
AGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTT
TCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTG
GATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAGAGGCTTGGTCCCACAGGCCACGGACCAATGGCCTGCAGCCGTGACAACA
CTCCTGTCATATTGGAGTCCAAAACTTGAATTCTGGGTTGAATTTTTTAAAAATCAGGTACCACTTGATTTCATATGGGAAATTGAAGCA
GGAAATATTGAGGGCTTCTTGATCACAGAAAACTCAGAAGAGATAGTAATGCTCAGGACAGGAGCGGCAGCCCCAGAACAGGCCACTCAT
TTAGAATTCTAGTGTTTCAAAACACTTTTGTGTGTTGTATGGTCAATAACATTTTTCATTACTGATGGTGTCATTCACCCATTAGGTAAA
CATTCCCTTTTAAATGTTTGTTTGTTTTTTGAGACAGGATCTCACTCTGTTGCCAGGGCTGTAGTGCAGTGGTGTGATCATAGCTCACTG
CAACCTCCACCTCCCAGGCTCAAGCCTCCCGAATAGCTGGGACTACAGGCGCACACCACCATCCCCGGCTAATTTTTGTATTTTTTGTAG
AGACGGGGTTTTGCCATGTTGCCAAGGCTGGTTTCAAACTCCTGGACTCAAGAAATCCACCCACCTCAGCCTCCCAAAGTGCTAGGATTA
CAGGCATGAGCCACTGCGCCCAGCCCTTATAAATTTTTGTATAGACATTCCTTTGGTTGGAAGAATATTTATAGGCAATACAGTCAAAGT
TTCAAAATAGCATCACACAAAACATGTTTATAAATGAACAGGATGTAATGTACATAGATGACATTAAGAAAATTTGTATGAAATAATTTA
GTCATCATGAAATATTTAGTTGTCATATAAAAACCCACTGTTTGAGAATGATGCTACTCTGATCTAATGAATGTGAACATGTAGATGTTT
TGTGTGTATTTTTTTAAATGAAAACTCAAAATAAGACAAGTAATTTGTTGATAAATATTTTTAAAGATAACTCAGCATGTTTGTAAAGCA
GGATACATTTTACTAAAAGGTTCATTGGTTCCAATCACAGCTCATAGGTAGAGCAAAGAAAGGGTGGATGGATTGAAAAGATTAGCCTCT
GTCTCGGTGGCAGGTTCCCACCTCGCAAGCAATTGGAAACAAAACTTTTGGGGAGTTTTATTTTGCATTAGGGTGTGTTTTATGTTAAGC
AAAACATACTTTAGAAACAAATGAAAAAGGCAATTGAAAATCCCAGCTATTTCACCTAGATGGAATAGCCACCCTGAGCAGAACTTTGTG
ATGCTTCATTCTGTGGAATTTTGTGCTTGCTACTGTATAGTGCATGTGGTGTAGGTTACTCTAACTGGTTTTGTCGACGTAAACATTTAA
AGTGTTATATTTTTTATAAAAATGTTTATTTTTAATGATATGAGAAAAATTTTGTTAGGCCACAAAAACACTGCACTGTGAACATTTTAG
AAAAGGTATGTCAGACTGGGATTAATGACAGCATGATTTTCAATGACTGTAAATTGCGATAAGGAAATGTACTGATTGCCAATACACCCC
ACCCTCATTACATCATCAGGACTTGAAGCCAAGGGTTAACCCAGCAAGCTACAAAGAGGGTGTGTCACACTGAAACTCAATAGTTGAGTT
TGGCTGTTGTTGCAGGAAAATGATTATAACTAAAAGCTCTCTGATAGTGCAGAGACTTACCAGAAGACACAAGGAATTGTACTGAAGAGC
TATTACAATCCAAATATTGCCGTTTCATAAATGTAATAAGTAATACTAATTCACAGAGTATTGTAAATGGTGGATGACAAAAGAAAATCT
GCTCTGTGGAAAGAAAGAACTGTCTCTACCAGGGTCAAGAGCATGAACGCATCAATAGAAAGAACTCGGGGAAACATCCCATCAACAGGA
CTACACACTTGTATATACATTCTTGAGAACACTGCAATGTGAAAATCACGTTTGCTATTTATAAACTTGTCCTTAGATTAATGTGTCTGG
ACAGATTGTGGGAGTAAGTGATTCTTCTAAGAATTAGATACTTGTCACTGCCTATACCTGCAGCTGAACTGAATGGTACTTCGTATGTTA

>In-frame_ENST00000458284_ENST00000397752_TCGA-78-7220-01A_CAPZA2_chr7_116528244_+_MET_chr7_116414935_length(amino acids)=428AA_start in transcript=14_stop in transcript=1300
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVH
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL
LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDK
EYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP

--------------------------------------------------------------
>In-frame_ENST00000458284_ENST00000318493_TCGA-78-7220-01A_CAPZA2_chr7_116528244_+_MET_chr7_116414935_length(transcript)=1519nt_BP=156nt
AAGTCAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGA
AGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGA
ACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATGTCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGC
AAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAGCTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTG
TGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGTGTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTG
CTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTTTCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCA
ATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGGTCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATT
TCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTTATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCA
AAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATGCTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAG
ACATGTATGATAAAGAATACTATAGTGTACACAACAAAACAGGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTC
AAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTGCTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAA
ACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGACTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAA
AATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCTGAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGC
ACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATG
AGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAGTGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTT
TCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTCTTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTG

>In-frame_ENST00000458284_ENST00000318493_TCGA-78-7220-01A_CAPZA2_chr7_116528244_+_MET_chr7_116414935_length(amino acids)=428AA_start in transcript=14_stop in transcript=1300
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVH
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL
LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDK
EYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP

--------------------------------------------------------------
>In-frame_ENST00000490693_ENST00000397752_TCGA-78-7220-01A_CAPZA2_chr7_116528244_+_MET_chr7_116414935_length(transcript)=3522nt_BP=115nt
GCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCT
GGAGAATTTAATGAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATG
TCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAG
CTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGT
GTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTT
TCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGG
TCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTT
ATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATG
CTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACA
GGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTG
CTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGA
CTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCT
GAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGT
GTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAG
TGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTC
TTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAG
AGGCTTGGTCCCACAGGCCACGGACCAATGGCCTGCAGCCGTGACAACACTCCTGTCATATTGGAGTCCAAAACTTGAATTCTGGGTTGA
ATTTTTTAAAAATCAGGTACCACTTGATTTCATATGGGAAATTGAAGCAGGAAATATTGAGGGCTTCTTGATCACAGAAAACTCAGAAGA
GATAGTAATGCTCAGGACAGGAGCGGCAGCCCCAGAACAGGCCACTCATTTAGAATTCTAGTGTTTCAAAACACTTTTGTGTGTTGTATG
GTCAATAACATTTTTCATTACTGATGGTGTCATTCACCCATTAGGTAAACATTCCCTTTTAAATGTTTGTTTGTTTTTTGAGACAGGATC
TCACTCTGTTGCCAGGGCTGTAGTGCAGTGGTGTGATCATAGCTCACTGCAACCTCCACCTCCCAGGCTCAAGCCTCCCGAATAGCTGGG
ACTACAGGCGCACACCACCATCCCCGGCTAATTTTTGTATTTTTTGTAGAGACGGGGTTTTGCCATGTTGCCAAGGCTGGTTTCAAACTC
CTGGACTCAAGAAATCCACCCACCTCAGCCTCCCAAAGTGCTAGGATTACAGGCATGAGCCACTGCGCCCAGCCCTTATAAATTTTTGTA
TAGACATTCCTTTGGTTGGAAGAATATTTATAGGCAATACAGTCAAAGTTTCAAAATAGCATCACACAAAACATGTTTATAAATGAACAG
GATGTAATGTACATAGATGACATTAAGAAAATTTGTATGAAATAATTTAGTCATCATGAAATATTTAGTTGTCATATAAAAACCCACTGT
TTGAGAATGATGCTACTCTGATCTAATGAATGTGAACATGTAGATGTTTTGTGTGTATTTTTTTAAATGAAAACTCAAAATAAGACAAGT
AATTTGTTGATAAATATTTTTAAAGATAACTCAGCATGTTTGTAAAGCAGGATACATTTTACTAAAAGGTTCATTGGTTCCAATCACAGC
TCATAGGTAGAGCAAAGAAAGGGTGGATGGATTGAAAAGATTAGCCTCTGTCTCGGTGGCAGGTTCCCACCTCGCAAGCAATTGGAAACA
AAACTTTTGGGGAGTTTTATTTTGCATTAGGGTGTGTTTTATGTTAAGCAAAACATACTTTAGAAACAAATGAAAAAGGCAATTGAAAAT
CCCAGCTATTTCACCTAGATGGAATAGCCACCCTGAGCAGAACTTTGTGATGCTTCATTCTGTGGAATTTTGTGCTTGCTACTGTATAGT
GCATGTGGTGTAGGTTACTCTAACTGGTTTTGTCGACGTAAACATTTAAAGTGTTATATTTTTTATAAAAATGTTTATTTTTAATGATAT
GAGAAAAATTTTGTTAGGCCACAAAAACACTGCACTGTGAACATTTTAGAAAAGGTATGTCAGACTGGGATTAATGACAGCATGATTTTC
AATGACTGTAAATTGCGATAAGGAAATGTACTGATTGCCAATACACCCCACCCTCATTACATCATCAGGACTTGAAGCCAAGGGTTAACC
CAGCAAGCTACAAAGAGGGTGTGTCACACTGAAACTCAATAGTTGAGTTTGGCTGTTGTTGCAGGAAAATGATTATAACTAAAAGCTCTC
TGATAGTGCAGAGACTTACCAGAAGACACAAGGAATTGTACTGAAGAGCTATTACAATCCAAATATTGCCGTTTCATAAATGTAATAAGT
AATACTAATTCACAGAGTATTGTAAATGGTGGATGACAAAAGAAAATCTGCTCTGTGGAAAGAAAGAACTGTCTCTACCAGGGTCAAGAG
CATGAACGCATCAATAGAAAGAACTCGGGGAAACATCCCATCAACAGGACTACACACTTGTATATACATTCTTGAGAACACTGCAATGTG
AAAATCACGTTTGCTATTTATAAACTTGTCCTTAGATTAATGTGTCTGGACAGATTGTGGGAGTAAGTGATTCTTCTAAGAATTAGATAC
TTGTCACTGCCTATACCTGCAGCTGAACTGAATGGTACTTCGTATGTTAATAGTTGTTCTGATAAATCATGCAATTAAAGTAAAGTGATG

>In-frame_ENST00000490693_ENST00000397752_TCGA-78-7220-01A_CAPZA2_chr7_116528244_+_MET_chr7_116414935_length(amino acids)=415AA_start in transcript=12_stop in transcript=1259
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQA
VQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLV
VLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL
PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS

--------------------------------------------------------------
>In-frame_ENST00000490693_ENST00000318493_TCGA-78-7220-01A_CAPZA2_chr7_116528244_+_MET_chr7_116414935_length(transcript)=1478nt_BP=115nt
GCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCT
GGAGAATTTAATGAGGTTTTCAATGATCAGTTTCCTAATTCATCTCAGAACGGTTCATGCCGACAAGTGCAGTATCCTCTGACAGACATG
TCCCCCATCCTAACTAGTGGGGACTCTGATATATCCAGTCCATTACTGCAAAATACTGTCCACATTGACCTCAGTGCTCTAAATCCAGAG
CTGGTCCAGGCAGTGCAGCATGTAGTGATTGGGCCCAGTAGCCTGATTGTGCATTTCAATGAAGTCATAGGAAGAGGGCATTTTGGTTGT
GTATATCATGGGACTTTGTTGGACAATGATGGCAAGAAAATTCACTGTGCTGTGAAATCCTTGAACAGAATCACTGACATAGGAGAAGTT
TCCCAATTTCTGACCGAGGGAATCATCATGAAAGATTTTAGTCATCCCAATGTCCTCTCGCTCCTGGGAATCTGCCTGCGAAGTGAAGGG
TCTCCGCTGGTGGTCCTACCATACATGAAACATGGAGATCTTCGAAATTTCATTCGAAATGAGACTCATAATCCAACTGTAAAAGATCTT
ATTGGCTTTGGTCTTCAAGTAGCCAAAGGCATGAAATATCTTGCAAGCAAAAAGTTTGTCCACAGAGACTTGGCTGCAAGAAACTGTATG
CTGGATGAAAAATTCACAGTCAAGGTTGCTGATTTTGGTCTTGCCAGAGACATGTATGATAAAGAATACTATAGTGTACACAACAAAACA
GGTGCAAAGCTGCCAGTGAAGTGGATGGCTTTGGAAAGTCTGCAAACTCAAAAGTTTACCACCAAGTCAGATGTGTGGTCCTTTGGCGTG
CTCCTCTGGGAGCTGATGACAAGAGGAGCCCCACCTTATCCTGACGTAAACACCTTTGATATAACTGTTTACTTGTTGCAAGGGAGAAGA
CTCCTACAACCCGAATACTGCCCAGACCCCTTATATGAAGTAATGCTAAAATGCTGGCACCCTAAAGCCGAAATGCGCCCATCCTTTTCT
GAACTGGTGTCCCGGATATCAGCGATCTTCTCTACTTTCATTGGGGAGCACTATGTCCATGTGAACGCTACTTATGTGAACGTAAAATGT
GTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATGATGAGGTGGACACACGACCAGCCTCCTTCTGGGAGACATCATAG
TGCTAGTACTATGTCAAAGCAACAGTCCACACTTTGTCCAATGGTTTTTTCACTGCCTGACCTTTAAAAGGCCATCGATATTCTTTGCTC
TTGCCAAAATTGCACTATTATAGGACTTGTATTGTTATTTAAATTACTGGATTCTAAGGAATTTCTTATCTGACAGAGCATCAGAACCAG

>In-frame_ENST00000490693_ENST00000318493_TCGA-78-7220-01A_CAPZA2_chr7_116528244_+_MET_chr7_116414935_length(amino acids)=415AA_start in transcript=12_stop in transcript=1259
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQA
VQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLV
VLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKL
PVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CAPZA2-MET


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMETchr7:116502704chr7:116435709ENST0000031849318211320_13591284.01409.0MUC20
TgeneMETchr7:116502704chr7:116435709ENST0000039775218211320_13591266.01391.0MUC20
TgeneMETchr7:116502704chr7:116435709ENST00000436117091320_13590.0765.0MUC20
TgeneMETchr7:116528244chr7:116414935ENST0000031849313211320_13591027.33333333333331409.0MUC20
TgeneMETchr7:116528244chr7:116414935ENST0000039775213211320_13591009.33333333333341391.0MUC20
TgeneMETchr7:116528244chr7:116414935ENST00000436117091320_13590.0765.0MUC20
TgeneMETchr7:116550365chr7:116409699ENST0000031849310211320_1359879.01409.0MUC20
TgeneMETchr7:116550365chr7:116409699ENST0000039775210211320_1359861.01391.0MUC20
TgeneMETchr7:116550365chr7:116409699ENST00000436117091320_13590.0765.0MUC20
TgeneMETchr7:116502704chr7:116435709ENST00000436117091212_13900.0765.0RANBP9
TgeneMETchr7:116528244chr7:116414935ENST0000031849313211212_13901027.33333333333331409.0RANBP9
TgeneMETchr7:116528244chr7:116414935ENST0000039775213211212_13901009.33333333333341391.0RANBP9
TgeneMETchr7:116528244chr7:116414935ENST00000436117091212_13900.0765.0RANBP9
TgeneMETchr7:116550365chr7:116409699ENST0000031849310211212_1390879.01409.0RANBP9
TgeneMETchr7:116550365chr7:116409699ENST0000039775210211212_1390861.01391.0RANBP9
TgeneMETchr7:116550365chr7:116409699ENST00000436117091212_13900.0765.0RANBP9


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMETchr7:116502704chr7:116435709ENST0000031849318211212_13901284.01409.0RANBP9
TgeneMETchr7:116502704chr7:116435709ENST0000039775218211212_13901266.01391.0RANBP9


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAPZA2-MET


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAPZA2-MET


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMETC1306837Papillary Renal Cell Carcinoma9CGI;CLINGEN;CTD_human;ORPHANET
TgeneMETC1336078Papillary renal cell carcinoma, sporadic7CLINGEN
TgeneMETC1336839Type 1 Papillary Renal Cell Carcinoma5UNIPROT
TgeneMETC0007131Non-Small Cell Lung Carcinoma4CGI;CTD_human
TgeneMETC1836723Tibia, Bowing of, with Pseudarthrosis and Pectus Excavatum4ORPHANET
TgeneMETC4085248OSTEOFIBROUS DYSPLASIA, SUSCEPTIBILITY TO4ORPHANET
TgeneMETC0001418Adenocarcinoma2CTD_human
TgeneMETC0004352Autistic Disorder2CTD_human
TgeneMETC0024623Malignant neoplasm of stomach2CGI;CTD_human;UNIPROT
TgeneMETC0027627Neoplasm Metastasis2CTD_human
TgeneMETC0038356Stomach Neoplasms2CGI;CTD_human
TgeneMETC0205641Adenocarcinoma, Basal Cell2CTD_human
TgeneMETC0205642Adenocarcinoma, Oxyphilic2CTD_human
TgeneMETC0205643Carcinoma, Cribriform2CTD_human
TgeneMETC0205644Carcinoma, Granular Cell2CTD_human
TgeneMETC0205645Adenocarcinoma, Tubular2CTD_human
TgeneMETC1708349Hereditary Diffuse Gastric Cancer2CTD_human
TgeneMETC0004114Astrocytoma1CTD_human
TgeneMETC0007097Carcinoma1CTD_human
TgeneMETC0007134Renal Cell Carcinoma1CTD_human
TgeneMETC0007137Squamous cell carcinoma1CTD_human
TgeneMETC0009241Cognition Disorders1CTD_human
TgeneMETC0014859Esophageal Neoplasms1CTD_human
TgeneMETC0017636Glioblastoma1CTD_human
TgeneMETC0019189Hepatitis, Chronic1CTD_human
TgeneMETC0019207Hepatoma, Morris1CTD_human
TgeneMETC0019208Hepatoma, Novikoff1CTD_human
TgeneMETC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneMETC0023904Liver Neoplasms, Experimental1CTD_human
TgeneMETC0024121Lung Neoplasms1CTD_human
TgeneMETC0024232Lymphatic Metastasis1CTD_human
TgeneMETC0025202melanoma1CTD_human
TgeneMETC0026998Acute Myeloid Leukemia, M11CTD_human
TgeneMETC0027626Neoplasm Invasiveness1CTD_human
TgeneMETC0027819Neuroblastoma1CTD_human
TgeneMETC0029463Osteosarcoma1CTD_human
TgeneMETC0033578Prostatic Neoplasms1CTD_human
TgeneMETC0036341Schizophrenia1CTD_human
TgeneMETC0037199Sinusitis1CTD_human
TgeneMETC0086404Experimental Hepatoma1CTD_human
TgeneMETC0149519Chronic Persistent Hepatitis1CTD_human
TgeneMETC0205696Anaplastic carcinoma1CTD_human
TgeneMETC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneMETC0205698Undifferentiated carcinoma1CTD_human
TgeneMETC0205699Carcinomatosis1CTD_human
TgeneMETC0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneMETC0242379Malignant neoplasm of lung1CTD_human
TgeneMETC0279606Childhood Hepatocellular Carcinoma1ORPHANET
TgeneMETC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CGI;CTD_human
TgeneMETC0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneMETC0280785Diffuse Astrocytoma1CTD_human
TgeneMETC0334579Anaplastic astrocytoma1CTD_human
TgeneMETC0334580Protoplasmic astrocytoma1CTD_human
TgeneMETC0334581Gemistocytic astrocytoma1CTD_human
TgeneMETC0334582Fibrillary Astrocytoma1CTD_human
TgeneMETC0334583Pilocytic Astrocytoma1CTD_human
TgeneMETC0334588Giant Cell Glioblastoma1CTD_human
TgeneMETC0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneMETC0345967Malignant mesothelioma1CTD_human
TgeneMETC0376358Malignant neoplasm of prostate1CTD_human
TgeneMETC0520463Chronic active hepatitis1CTD_human
TgeneMETC0524611Cryptogenic Chronic Hepatitis1CTD_human
TgeneMETC0546837Malignant neoplasm of esophagus1CTD_human
TgeneMETC0547065Mixed oligoastrocytoma1CTD_human
TgeneMETC0750935Cerebral Astrocytoma1CTD_human
TgeneMETC0750936Intracranial Astrocytoma1CTD_human
TgeneMETC0919267ovarian neoplasm1CTD_human
TgeneMETC1140680Malignant neoplasm of ovary1CTD_human
TgeneMETC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneMETC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneMETC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneMETC1621958Glioblastoma Multiforme1CTD_human
TgeneMETC1704230Grade I Astrocytoma1CTD_human
TgeneMETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome1CLINGEN
TgeneMETC1876165Copper-Overload Cirrhosis1CTD_human
TgeneMETC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneMETC2239176Liver carcinoma1CGI;CTD_human;UNIPROT
TgeneMETC3711374Nonsyndromic Deafness1CLINGEN
TgeneMETC4084709DEAFNESS, AUTOSOMAL RECESSIVE 971CTD_human;UNIPROT