FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CAPZB-SLC25A43 (FusionGDB2 ID:13059)

Fusion Gene Summary for CAPZB-SLC25A43

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPZB-SLC25A43
Fusion gene ID: 13059
HgeneTgene
Gene symbol

CAPZB

SLC25A43

Gene ID

832

203427

Gene namecapping actin protein of muscle Z-line subunit betasolute carrier family 25 member 43
SynonymsCAPB|CAPPB|CAPZ-
Cytomap

1p36.13

Xq24

Type of geneprotein-codingprotein-coding
DescriptionF-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, betaepididymis secretory sperm binding proteinsolute carrier family 25 member 43
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000401084, ENST00000264203, 
ENST00000375142, ENST00000433834, 
ENST00000264202, ENST00000482808, 
ENST00000375144, 		ENST00000217909, 
ENST00000336249, ENST00000488158, 
Fusion gene scores* DoF score20 X 22 X 11=48405 X 6 X 4=120
# samples 297
** MAII scorelog2(29/4840*10)=-4.06088224214702
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPZB [Title/Abstract] AND SLC25A43 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAPZB(19811930)-SLC25A43(118585972), # samples:1
Anticipated loss of major functional domain due to fusion event.CAPZB-SLC25A43 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CAPZB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SLC25A43 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4QI-01ACAPZBchr1

19811930

-SLC25A43chrX

118585972

+


Top

Fusion Gene ORF analysis for CAPZB-SLC25A43

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000401084ENST00000217909CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
Frame-shiftENST00000401084ENST00000336249CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
5CDS-3UTRENST00000401084ENST00000488158CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
5UTR-3CDSENST00000264203ENST00000217909CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
5UTR-3CDSENST00000264203ENST00000336249CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
5UTR-3UTRENST00000264203ENST00000488158CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
In-frameENST00000375142ENST00000217909CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
Frame-shiftENST00000375142ENST00000336249CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
5CDS-3UTRENST00000375142ENST00000488158CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
intron-3CDSENST00000433834ENST00000217909CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
intron-3CDSENST00000433834ENST00000336249CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
intron-3UTRENST00000433834ENST00000488158CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
In-frameENST00000264202ENST00000217909CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
Frame-shiftENST00000264202ENST00000336249CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
5CDS-3UTRENST00000264202ENST00000488158CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
5UTR-3CDSENST00000482808ENST00000217909CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
5UTR-3CDSENST00000482808ENST00000336249CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
5UTR-3UTRENST00000482808ENST00000488158CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
intron-3CDSENST00000375144ENST00000217909CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
intron-3CDSENST00000375144ENST00000336249CAPZBchr1

19811930

-SLC25A43chrX

118585972

+
intron-3UTRENST00000375144ENST00000488158CAPZBchr1

19811930

-SLC25A43chrX

118585972

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000401084CAPZBchr119811930-ENST00000217909SLC25A43chrX118585972+1886137134472112
ENST00000375142CAPZBchr119811930-ENST00000217909SLC25A43chrX118585972+17995047385112
ENST00000264202CAPZBchr119811930-ENST00000217909SLC25A43chrX118585972+18015249387112

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000401084ENST00000217909CAPZBchr119811930-SLC25A43chrX118585972+0.063930080.9360699
ENST00000375142ENST00000217909CAPZBchr119811930-SLC25A43chrX118585972+0.0586305070.94136953
ENST00000264202ENST00000217909CAPZBchr119811930-SLC25A43chrX118585972+0.074592150.9254078

Top

Fusion Genomic Features for CAPZB-SLC25A43


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CAPZBchr119811929-SLC25A43chrX118585971+3.00E-091
CAPZBchr119811929-SLC25A43chrX118585971+3.00E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CAPZB-SLC25A43


check button Go to

FGviewer for the breakpoints of chr1:19811930-chrX:118585972

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC25A43chr1:19811930chrX:118585972ENST0000021790925262_282230.0342.0TransmembraneHelical%3B Name%3D6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC25A43chr1:19811930chrX:118585972ENST0000021790925105_185230.0342.0RepeatNote=Solcar 2
TgeneSLC25A43chr1:19811930chrX:118585972ENST000002179092511_101230.0342.0RepeatNote=Solcar 1
TgeneSLC25A43chr1:19811930chrX:118585972ENST0000021790925200_298230.0342.0RepeatNote=Solcar 3
TgeneSLC25A43chr1:19811930chrX:118585972ENST0000021790925110_130230.0342.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A43chr1:19811930chrX:118585972ENST0000021790925166_186230.0342.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A43chr1:19811930chrX:118585972ENST000002179092516_36230.0342.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A43chr1:19811930chrX:118585972ENST0000021790925205_225230.0342.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A43chr1:19811930chrX:118585972ENST000002179092568_88230.0342.0TransmembraneHelical%3B Name%3D2


Top

Fusion Gene Sequence for CAPZB-SLC25A43


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000401084_ENST00000217909_TCGA-BR-A4QI-01A_CAPZB_chr1_19811930_-_SLC25A43_chrX_118585972_length(transcript)=1886nt_BP=137nt
GCCCGGCGCGGGGGGAGGGGGGTGCTGACCCGGATGTTCACTCCTGGGCACCCGGGGAAGTGGAAGCGCCGGGCCCTGCTGCGGGGGGGA
GAGCCACTGACGCCGGGACCGGGACCGCCGCCGCCGCCGCCACCATGGCTCAGAGCCCCTACCTCCCACACAGTGGAGGAGTAGATGTCC
ATTTCTCAGGAGCAGTGGACTGCTTCCGGCAGATAGTGAAGGCCCAGGGGGTCCTGGGGCTCTGGAATGGATTGACAGCCAATTTACTGA
AGATAGTTCCATATTTTGGAATTATGTTTAGCACCTTTGAGTTCTGCAAGAGAATCTGTCTTTATCAAAATGGTTACATTCTGTCTCCAC
TGAGCTATAAATTGACCCCAGGAGTCGATCAGAGTTTGCAGCCCCAGGAATTACGAGAATTAAAGAAGTTCTTCAAAACGAGAAAACCGA
AGCCTAAAAAACCAACTCTATAAAATGGAATGGAACTAGAAGTGCACTGACTGACAGCATGTTGCAATCACAGATAAATGTAGCCTCATA
ACTGTGCACCTGAGGAGGGATGAGAAGCTACTGCTATCTGCTGCTCTGGGAAATGAGATGGTTTGGCCATGCACCACCTCAGATCTCCAA
ACTGATGTCCCTGTGAACACCTGCACTATGAGAAGGTTTCCCAACAAGAGTGTATCATGATGGCATTCCACGAGATTTTATAACCAGAGT
CTAGCAGTGATAAAATGTACAATTTACGCTCTGAATAGAAACATGACACCAAAGAAAGGGCATTGCCATGACATCTCAAAGCAACAGGTA
ATTGAAGTGGCTGAGTGGATACCACGTTGTGAGGTCAGCCACTGGGTCACTTGTAGTCAATGCAAAGCTTGCACAAACCAACGTCAGCCT
AGTTTCACTCAGTTTGACCTGAGACTTTCCAATACAATCTGTTGTTTTGTTTTGTTTTTAGAGACAGGGTCTTGCTCTGTCACCCAGACT
GGAGTACAATGACACAATCATAGCTCACTGCAGCCTTTAACTACTGGGCTCAAGACATCCTCCTGCTTCAGCCTCCAGAGAGTTGGGACC
ATAGGTGCACACCACCACACCTAGCTAATTTTTTGGGGAGGTCTTGCTATGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTCATGCAATC
CTCCTGCCTTGGCCTCCCAAAGCGCTAGGATTAGAGGTGTGAGCCGCTGCACCCTGCCCCAGTACAATCTTTTTTGAACTCAAATTTTTG
CTGACATCTGAGTGCACACACCACAGTGTAAATTATGCCTTATCAGAATCTAAATGAAAATAGCGAACATTTAAAAGCTATCACCATTGT
AGTAGAATCATCCTTCTTTTTTGAAATTTGAAGCATCCCAGGCTTAAAATCTTGTGTTTCAGAAAGACAGTTTATACCATGACTGCTTAA
TTATCCCCCCAAAGACCTTCTGATTGAAGTCATGTACAGTTCAGTGGCCTAAATTCTCTGCCTTTTTAACTTGCTTTGCAAGCCTACTCT
GAAAATAAGTTATTTAGTCAAGTTATTCTCAAAGATGTCCCAGTTGCCTAGAAAGGATCAAATGGAACATTTGACACACATACTCAAAAA
AATGTAACTGACTATAAACACTTTAACCTAATCATCTGTATCAAACTTTCTAAAAATCAAATCTCAGGATTGTTCCACTTTAGAGATTCT
ATGTAAAGTTTATATAACTATACTTGTCAAATAGCACCTATCTATGCATTTAAAAATGCATTAATATCTAACATAAAATTGTTAATTTAT

>In-frame_ENST00000401084_ENST00000217909_TCGA-BR-A4QI-01A_CAPZB_chr1_19811930_-_SLC25A43_chrX_118585972_length(amino acids)=112AA_start in transcript=134_stop in transcript=472
MAQSPYLPHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLKIVPYFGIMFSTFEFCKRICLYQNGYILSPLSYKLTPGVDQSLQP

--------------------------------------------------------------
>In-frame_ENST00000375142_ENST00000217909_TCGA-BR-A4QI-01A_CAPZB_chr1_19811930_-_SLC25A43_chrX_118585972_length(transcript)=1799nt_BP=50nt
GGAGAGCCACTGACGCCGGGACCGGGACCGCCGCCGCCGCCGCCACCATGGCTCAGAGCCCCTACCTCCCACACAGTGGAGGAGTAGATG
TCCATTTCTCAGGAGCAGTGGACTGCTTCCGGCAGATAGTGAAGGCCCAGGGGGTCCTGGGGCTCTGGAATGGATTGACAGCCAATTTAC
TGAAGATAGTTCCATATTTTGGAATTATGTTTAGCACCTTTGAGTTCTGCAAGAGAATCTGTCTTTATCAAAATGGTTACATTCTGTCTC
CACTGAGCTATAAATTGACCCCAGGAGTCGATCAGAGTTTGCAGCCCCAGGAATTACGAGAATTAAAGAAGTTCTTCAAAACGAGAAAAC
CGAAGCCTAAAAAACCAACTCTATAAAATGGAATGGAACTAGAAGTGCACTGACTGACAGCATGTTGCAATCACAGATAAATGTAGCCTC
ATAACTGTGCACCTGAGGAGGGATGAGAAGCTACTGCTATCTGCTGCTCTGGGAAATGAGATGGTTTGGCCATGCACCACCTCAGATCTC
CAAACTGATGTCCCTGTGAACACCTGCACTATGAGAAGGTTTCCCAACAAGAGTGTATCATGATGGCATTCCACGAGATTTTATAACCAG
AGTCTAGCAGTGATAAAATGTACAATTTACGCTCTGAATAGAAACATGACACCAAAGAAAGGGCATTGCCATGACATCTCAAAGCAACAG
GTAATTGAAGTGGCTGAGTGGATACCACGTTGTGAGGTCAGCCACTGGGTCACTTGTAGTCAATGCAAAGCTTGCACAAACCAACGTCAG
CCTAGTTTCACTCAGTTTGACCTGAGACTTTCCAATACAATCTGTTGTTTTGTTTTGTTTTTAGAGACAGGGTCTTGCTCTGTCACCCAG
ACTGGAGTACAATGACACAATCATAGCTCACTGCAGCCTTTAACTACTGGGCTCAAGACATCCTCCTGCTTCAGCCTCCAGAGAGTTGGG
ACCATAGGTGCACACCACCACACCTAGCTAATTTTTTGGGGAGGTCTTGCTATGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTCATGCA
ATCCTCCTGCCTTGGCCTCCCAAAGCGCTAGGATTAGAGGTGTGAGCCGCTGCACCCTGCCCCAGTACAATCTTTTTTGAACTCAAATTT
TTGCTGACATCTGAGTGCACACACCACAGTGTAAATTATGCCTTATCAGAATCTAAATGAAAATAGCGAACATTTAAAAGCTATCACCAT
TGTAGTAGAATCATCCTTCTTTTTTGAAATTTGAAGCATCCCAGGCTTAAAATCTTGTGTTTCAGAAAGACAGTTTATACCATGACTGCT
TAATTATCCCCCCAAAGACCTTCTGATTGAAGTCATGTACAGTTCAGTGGCCTAAATTCTCTGCCTTTTTAACTTGCTTTGCAAGCCTAC
TCTGAAAATAAGTTATTTAGTCAAGTTATTCTCAAAGATGTCCCAGTTGCCTAGAAAGGATCAAATGGAACATTTGACACACATACTCAA
AAAAATGTAACTGACTATAAACACTTTAACCTAATCATCTGTATCAAACTTTCTAAAAATCAAATCTCAGGATTGTTCCACTTTAGAGAT
TCTATGTAAAGTTTATATAACTATACTTGTCAAATAGCACCTATCTATGCATTTAAAAATGCATTAATATCTAACATAAAATTGTTAATT

>In-frame_ENST00000375142_ENST00000217909_TCGA-BR-A4QI-01A_CAPZB_chr1_19811930_-_SLC25A43_chrX_118585972_length(amino acids)=112AA_start in transcript=47_stop in transcript=385
MAQSPYLPHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLKIVPYFGIMFSTFEFCKRICLYQNGYILSPLSYKLTPGVDQSLQP

--------------------------------------------------------------
>In-frame_ENST00000264202_ENST00000217909_TCGA-BR-A4QI-01A_CAPZB_chr1_19811930_-_SLC25A43_chrX_118585972_length(transcript)=1801nt_BP=52nt
GGGGAGAGCCACTGACGCCGGGACCGGGACCGCCGCCGCCGCCGCCACCATGGCTCAGAGCCCCTACCTCCCACACAGTGGAGGAGTAGA
TGTCCATTTCTCAGGAGCAGTGGACTGCTTCCGGCAGATAGTGAAGGCCCAGGGGGTCCTGGGGCTCTGGAATGGATTGACAGCCAATTT
ACTGAAGATAGTTCCATATTTTGGAATTATGTTTAGCACCTTTGAGTTCTGCAAGAGAATCTGTCTTTATCAAAATGGTTACATTCTGTC
TCCACTGAGCTATAAATTGACCCCAGGAGTCGATCAGAGTTTGCAGCCCCAGGAATTACGAGAATTAAAGAAGTTCTTCAAAACGAGAAA
ACCGAAGCCTAAAAAACCAACTCTATAAAATGGAATGGAACTAGAAGTGCACTGACTGACAGCATGTTGCAATCACAGATAAATGTAGCC
TCATAACTGTGCACCTGAGGAGGGATGAGAAGCTACTGCTATCTGCTGCTCTGGGAAATGAGATGGTTTGGCCATGCACCACCTCAGATC
TCCAAACTGATGTCCCTGTGAACACCTGCACTATGAGAAGGTTTCCCAACAAGAGTGTATCATGATGGCATTCCACGAGATTTTATAACC
AGAGTCTAGCAGTGATAAAATGTACAATTTACGCTCTGAATAGAAACATGACACCAAAGAAAGGGCATTGCCATGACATCTCAAAGCAAC
AGGTAATTGAAGTGGCTGAGTGGATACCACGTTGTGAGGTCAGCCACTGGGTCACTTGTAGTCAATGCAAAGCTTGCACAAACCAACGTC
AGCCTAGTTTCACTCAGTTTGACCTGAGACTTTCCAATACAATCTGTTGTTTTGTTTTGTTTTTAGAGACAGGGTCTTGCTCTGTCACCC
AGACTGGAGTACAATGACACAATCATAGCTCACTGCAGCCTTTAACTACTGGGCTCAAGACATCCTCCTGCTTCAGCCTCCAGAGAGTTG
GGACCATAGGTGCACACCACCACACCTAGCTAATTTTTTGGGGAGGTCTTGCTATGTTGCCCAGGCTGGTCTTGAACTCCTGGGCTCATG
CAATCCTCCTGCCTTGGCCTCCCAAAGCGCTAGGATTAGAGGTGTGAGCCGCTGCACCCTGCCCCAGTACAATCTTTTTTGAACTCAAAT
TTTTGCTGACATCTGAGTGCACACACCACAGTGTAAATTATGCCTTATCAGAATCTAAATGAAAATAGCGAACATTTAAAAGCTATCACC
ATTGTAGTAGAATCATCCTTCTTTTTTGAAATTTGAAGCATCCCAGGCTTAAAATCTTGTGTTTCAGAAAGACAGTTTATACCATGACTG
CTTAATTATCCCCCCAAAGACCTTCTGATTGAAGTCATGTACAGTTCAGTGGCCTAAATTCTCTGCCTTTTTAACTTGCTTTGCAAGCCT
ACTCTGAAAATAAGTTATTTAGTCAAGTTATTCTCAAAGATGTCCCAGTTGCCTAGAAAGGATCAAATGGAACATTTGACACACATACTC
AAAAAAATGTAACTGACTATAAACACTTTAACCTAATCATCTGTATCAAACTTTCTAAAAATCAAATCTCAGGATTGTTCCACTTTAGAG
ATTCTATGTAAAGTTTATATAACTATACTTGTCAAATAGCACCTATCTATGCATTTAAAAATGCATTAATATCTAACATAAAATTGTTAA
TTTATACACACACATACACTCATACATAGAGAGAGATTTTCGGTATGTTGCAAGTATTTTTTCCGATTAAATTTATTTTCCAAAGAAAAA

>In-frame_ENST00000264202_ENST00000217909_TCGA-BR-A4QI-01A_CAPZB_chr1_19811930_-_SLC25A43_chrX_118585972_length(amino acids)=112AA_start in transcript=49_stop in transcript=387
MAQSPYLPHSGGVDVHFSGAVDCFRQIVKAQGVLGLWNGLTANLLKIVPYFGIMFSTFEFCKRICLYQNGYILSPLSYKLTPGVDQSLQP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CAPZB-SLC25A43


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CAPZB-SLC25A43


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CAPZB-SLC25A43


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCAPZBC0007097Carcinoma1CTD_human
HgeneCAPZBC0024667Animal Mammary Neoplasms1CTD_human
HgeneCAPZBC0024668Mammary Neoplasms, Experimental1CTD_human
HgeneCAPZBC0205696Anaplastic carcinoma1CTD_human
HgeneCAPZBC0205697Carcinoma, Spindle-Cell1CTD_human
HgeneCAPZBC0205698Undifferentiated carcinoma1CTD_human
HgeneCAPZBC0205699Carcinomatosis1CTD_human
HgeneCAPZBC0948089Acute Coronary Syndrome1CTD_human
HgeneCAPZBC1257925Mammary Carcinoma, Animal1CTD_human