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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CARD8-SULT2B1 (FusionGDB2 ID:13089)

Fusion Gene Summary for CARD8-SULT2B1

Fusion gene summary

Fusion gene information	Fusion gene name: CARD8-SULT2B1
	Fusion gene ID: 13089
		Hgene	Tgene
	Gene symbol	CARD8	SULT2B1
	Gene ID	22900	6820
	Gene name	caspase recruitment domain family member 8	sulfotransferase family 2B member 1
	Synonyms	CARDINAL\|DACAR\|DAKAR\|NDPP\|NDPP1\|TUCAN	ARCI14\|HSST2
	Cytomap	19q13.33	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	caspase recruitment domain-containing protein 8CARD inhibitor of NF-kappaB-activating ligandsapoptotic protein NDPP1tumor up-regulated CARD-containing antagonist of CASP9tumor up-regulated CARD-containing antagonist of caspase nine	sulfotransferase 2B1ST2B1alcohol sulfotransferasehydroxysteroid sulfotransferase 2hydroxysteroid sulfotransferase SULT2B1asulfotransferase family, cytosolic, 2B, member 1
	Modification date	20200320	20200313
	UniProtAcc	Q9Y2G2	.
	Ensembl transtripts involved in fusion gene	ENST00000520753, ENST00000521613, ENST00000519940, ENST00000519332, ENST00000520007, ENST00000600800, ENST00000357778, ENST00000391898, ENST00000359009, ENST00000447740, ENST00000520153, ENST00000520015, ENST00000522431,	ENST00000201586, ENST00000323090, ENST00000594274,
Fusion gene scores	* DoF score	12 X 16 X 6=1152	6 X 7 X 4=168
	# samples	14	7
	** MAII score	log2(14/1152*10)=-3.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CARD8 [Title/Abstract] AND SULT2B1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CARD8(48752779)-SULT2B1(49099995), # samples:1 CARD8(48753007)-SULT2B1(49099995), # samples:1 CARD8(48752780)-SULT2B1(49099996), # samples:1 CARD8(48753008)-SULT2B1(49099996), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CARD8	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	11821383
Hgene	CARD8	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	11551959
Hgene	CARD8	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	11821383\|15030775
Hgene	CARD8	GO:0050713	negative regulation of interleukin-1 beta secretion	11821383
Hgene	CARD8	GO:0050718	positive regulation of interleukin-1 beta secretion	15030775
Hgene	CARD8	GO:0097340	inhibition of cysteine-type endopeptidase activity	11821383
Tgene	SULT2B1	GO:0008202	steroid metabolic process	9799594\|12145317
Tgene	SULT2B1	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process	12923182

Fusion gene breakpoints across CARD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SULT2B1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-06-5415	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
ChimerDB4	GBM	TCGA-06-5415	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
ChimerDB4	GBM	TCGA-06-5415-01A	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
ChimerDB4	GBM	TCGA-06-5415-01A	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+

Top

Fusion Gene ORF analysis for CARD8-SULT2B1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000520753	ENST00000201586	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520753	ENST00000323090	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000520753	ENST00000594274	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000521613	ENST00000201586	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000521613	ENST00000323090	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3UTR	ENST00000521613	ENST00000594274	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000519940	ENST00000201586	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000519940	ENST00000323090	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000519940	ENST00000594274	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000519332	ENST00000201586	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000519332	ENST00000323090	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3UTR	ENST00000519332	ENST00000594274	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520007	ENST00000201586	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520007	ENST00000323090	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000520007	ENST00000594274	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000600800	ENST00000201586	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000600800	ENST00000323090	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3UTR	ENST00000600800	ENST00000594274	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000357778	ENST00000201586	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000357778	ENST00000323090	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3UTR	ENST00000357778	ENST00000594274	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000391898	ENST00000201586	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000391898	ENST00000323090	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3UTR	ENST00000391898	ENST00000594274	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000359009	ENST00000201586	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000359009	ENST00000323090	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000359009	ENST00000594274	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000447740	ENST00000201586	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000447740	ENST00000323090	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3UTR	ENST00000447740	ENST00000594274	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520153	ENST00000201586	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520153	ENST00000323090	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000520153	ENST00000594274	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000520015	ENST00000201586	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000520015	ENST00000323090	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
intron-3UTR	ENST00000520015	ENST00000594274	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000522431	ENST00000201586	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000522431	ENST00000323090	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000522431	ENST00000594274	CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520753	ENST00000201586	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520753	ENST00000323090	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000520753	ENST00000594274	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000521613	ENST00000201586	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000521613	ENST00000323090	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000521613	ENST00000594274	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000519940	ENST00000201586	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000519940	ENST00000323090	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000519940	ENST00000594274	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000519332	ENST00000201586	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000519332	ENST00000323090	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000519332	ENST00000594274	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520007	ENST00000201586	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520007	ENST00000323090	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000520007	ENST00000594274	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000600800	ENST00000201586	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000600800	ENST00000323090	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
intron-3UTR	ENST00000600800	ENST00000594274	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000357778	ENST00000201586	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000357778	ENST00000323090	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000357778	ENST00000594274	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000391898	ENST00000201586	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000391898	ENST00000323090	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
intron-3UTR	ENST00000391898	ENST00000594274	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000359009	ENST00000201586	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000359009	ENST00000323090	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
intron-3UTR	ENST00000359009	ENST00000594274	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000447740	ENST00000201586	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000447740	ENST00000323090	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000447740	ENST00000594274	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520153	ENST00000201586	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520153	ENST00000323090	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000520153	ENST00000594274	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520015	ENST00000201586	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520015	ENST00000323090	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3UTR	ENST00000520015	ENST00000594274	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000522431	ENST00000201586	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
intron-3CDS	ENST00000522431	ENST00000323090	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
intron-3UTR	ENST00000522431	ENST00000594274	CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+
5UTR-3CDS	ENST00000520753	ENST00000201586	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000520753	ENST00000323090	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000520753	ENST00000594274	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000521613	ENST00000201586	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000521613	ENST00000323090	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3UTR	ENST00000521613	ENST00000594274	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000519940	ENST00000201586	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000519940	ENST00000323090	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000519940	ENST00000594274	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000519332	ENST00000201586	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000519332	ENST00000323090	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3UTR	ENST00000519332	ENST00000594274	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000520007	ENST00000201586	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000520007	ENST00000323090	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000520007	ENST00000594274	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000600800	ENST00000201586	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000600800	ENST00000323090	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3UTR	ENST00000600800	ENST00000594274	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000357778	ENST00000201586	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000357778	ENST00000323090	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3UTR	ENST00000357778	ENST00000594274	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000391898	ENST00000201586	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000391898	ENST00000323090	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3UTR	ENST00000391898	ENST00000594274	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000359009	ENST00000201586	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000359009	ENST00000323090	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000359009	ENST00000594274	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000447740	ENST00000201586	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000447740	ENST00000323090	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3UTR	ENST00000447740	ENST00000594274	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000520153	ENST00000201586	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000520153	ENST00000323090	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000520153	ENST00000594274	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000520015	ENST00000201586	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000520015	ENST00000323090	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
intron-3UTR	ENST00000520015	ENST00000594274	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000522431	ENST00000201586	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000522431	ENST00000323090	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000522431	ENST00000594274	CARD8	chr19	48752780	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000520753	ENST00000201586	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000520753	ENST00000323090	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000520753	ENST00000594274	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000521613	ENST00000201586	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000521613	ENST00000323090	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000521613	ENST00000594274	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000519940	ENST00000201586	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000519940	ENST00000323090	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000519940	ENST00000594274	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000519332	ENST00000201586	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000519332	ENST00000323090	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000519332	ENST00000594274	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000520007	ENST00000201586	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000520007	ENST00000323090	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000520007	ENST00000594274	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000600800	ENST00000201586	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000600800	ENST00000323090	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
intron-3UTR	ENST00000600800	ENST00000594274	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000357778	ENST00000201586	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000357778	ENST00000323090	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000357778	ENST00000594274	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000391898	ENST00000201586	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000391898	ENST00000323090	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
intron-3UTR	ENST00000391898	ENST00000594274	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000359009	ENST00000201586	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000359009	ENST00000323090	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
intron-3UTR	ENST00000359009	ENST00000594274	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000447740	ENST00000201586	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000447740	ENST00000323090	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000447740	ENST00000594274	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000520153	ENST00000201586	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000520153	ENST00000323090	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000520153	ENST00000594274	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000520015	ENST00000201586	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3CDS	ENST00000520015	ENST00000323090	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
5UTR-3UTR	ENST00000520015	ENST00000594274	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000522431	ENST00000201586	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
intron-3CDS	ENST00000522431	ENST00000323090	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+
intron-3UTR	ENST00000522431	ENST00000594274	CARD8	chr19	48753008	-	SULT2B1	chr19	49099996	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CARD8-SULT2B1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+	2.49E-06	0.9999975
CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+	2.49E-06	0.9999975
CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+	7.00E-09	1
CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+	7.00E-09	1
CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+	2.49E-06	0.9999975
CARD8	chr19	48752779	-	SULT2B1	chr19	49099995	+	2.49E-06	0.9999975
CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+	7.00E-09	1
CARD8	chr19	48753007	-	SULT2B1	chr19	49099995	+	7.00E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CARD8-SULT2B1

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CARD8 Q9Y2G2	.
FUNCTION: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CARD8-SULT2B1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CARD8-SULT2B1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CARD8-SULT2B1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CARD8-SULT2B1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CARD8	C0018099	Gout	1	CTD_human
Hgene	CARD8	C0028797	Occupational Diseases	1	CTD_human
Hgene	CARD8	C0032226	Pleural Diseases	1	CTD_human
Tgene	SULT2B1	C0008370	Cholestasis	1	CTD_human
Tgene	SULT2B1	C0009402	Colorectal Carcinoma	1	CTD_human
Tgene	SULT2B1	C0009404	Colorectal Neoplasms	1	CTD_human
Tgene	SULT2B1	C0014170	Endometrial Neoplasms	1	CTD_human
Tgene	SULT2B1	C0019193	Hepatitis, Toxic	1	CTD_human
Tgene	SULT2B1	C0021368	Inflammation	1	CTD_human
Tgene	SULT2B1	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	SULT2B1	C0079154	Congenital Nonbullous Ichthyosiform Erythroderma	1	ORPHANET
Tgene	SULT2B1	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	SULT2B1	C0476089	Endometrial Carcinoma	1	CTD_human
Tgene	SULT2B1	C0860207	Drug-Induced Liver Disease	1	CTD_human
Tgene	SULT2B1	C1262760	Hepatitis, Drug-Induced	1	CTD_human
Tgene	SULT2B1	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
Tgene	SULT2B1	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
Tgene	SULT2B1	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human
Tgene	SULT2B1	C4539754	ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 14	1	GENOMICS_ENGLAND;UNIPROT