FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ACADM-FOXJ3 (FusionGDB2 ID:1324)

Fusion Gene Summary for ACADM-FOXJ3

check button Fusion gene summary
Fusion gene informationFusion gene name: ACADM-FOXJ3
Fusion gene ID: 1324
HgeneTgene
Gene symbol

ACADM

FOXJ3

Gene ID

34

22887

Gene nameacyl-CoA dehydrogenase medium chainforkhead box J3
SynonymsACAD1|MCAD|MCADH-
Cytomap

1p31.1

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionmedium-chain specific acyl-CoA dehydrogenase, mitochondrialacyl-CoA dehydrogenase, C-4 to C-12 straight chainacyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chainmedium-chain acyl-CoA dehydrogenasetesticular tissue protein Li 7forkhead box protein J3
Modification date2020031320200313
UniProtAcc.

Q9UPW0

Ensembl transtripts involved in fusion geneENST00000370841, ENST00000370834, 
ENST00000541113, ENST00000543667, 
ENST00000420607, ENST00000481374, 
ENST00000372572, ENST00000372573, 
ENST00000361346, ENST00000361776, 
ENST00000545068, ENST00000372571, 
Fusion gene scores* DoF score3 X 3 X 3=279 X 7 X 4=252
# samples 38
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACADM [Title/Abstract] AND FOXJ3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACADM(76251959)-FOXJ3(42647695), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACADM

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

1902818|3597357|19224950|25416781

HgeneACADM

GO:0051791

medium-chain fatty acid metabolic process

1970566

HgeneACADM

GO:0051793

medium-chain fatty acid catabolic process

1970566

HgeneACADM

GO:0055114

oxidation-reduction process

1902818

TgeneFOXJ3

GO:0045944

positive regulation of transcription by RNA polymerase II

22740631


check buttonFusion gene breakpoints across ACADM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FOXJ3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-22-4601-01AACADMchr1

76251959

+FOXJ3chr1

42647695

-
ChimerDB4LUSCTCGA-22-4601ACADMchr1

76251959

+FOXJ3chr1

42647695

-


Top

Fusion Gene ORF analysis for ACADM-FOXJ3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000370841ENST00000372572ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000370841ENST00000372573ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000370841ENST00000361346ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000370841ENST00000361776ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000370841ENST00000545068ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000370841ENST00000372571ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000370834ENST00000372572ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000370834ENST00000372573ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000370834ENST00000361346ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000370834ENST00000361776ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000370834ENST00000545068ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000370834ENST00000372571ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000541113ENST00000372572ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000541113ENST00000372573ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000541113ENST00000361346ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000541113ENST00000361776ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000541113ENST00000545068ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000541113ENST00000372571ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000543667ENST00000372572ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000543667ENST00000372573ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000543667ENST00000361346ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000543667ENST00000361776ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000543667ENST00000545068ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000543667ENST00000372571ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000420607ENST00000372572ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000420607ENST00000372573ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000420607ENST00000361346ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000420607ENST00000361776ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000420607ENST00000545068ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000420607ENST00000372571ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000481374ENST00000372572ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000481374ENST00000372573ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000481374ENST00000361346ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000481374ENST00000361776ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000481374ENST00000545068ACADMchr1

76251959

+FOXJ3chr1

42647695

-
intron-3CDSENST00000481374ENST00000372571ACADMchr1

76251959

+FOXJ3chr1

42647695

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for ACADM-FOXJ3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ACADM-FOXJ3


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FOXJ3

Q9UPW0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration (By similarity). Plays an important role in spermatogenesis (By similarity). Required for the survival of spermatogonia and participates in spermatocyte meiosis (By similarity). {ECO:0000250|UniProtKB:Q8BUR3}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for ACADM-FOXJ3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for ACADM-FOXJ3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ACADM-FOXJ3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ACADM-FOXJ3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACADMC0220710Medium-chain acyl-coenzyme A dehydrogenase deficiency24CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneACADMC0028754Obesity1CTD_human
HgeneACADMC0043094Weight Gain1CTD_human
HgeneACADMC0085605Liver Failure1CTD_human
HgeneACADMC0520459Necrotizing Enterocolitis1CTD_human