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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CASKIN2-PDE2A (FusionGDB2 ID:13251)

Fusion Gene Summary for CASKIN2-PDE2A

check button Fusion gene summary
Fusion gene informationFusion gene name: CASKIN2-PDE2A
Fusion gene ID: 13251
HgeneTgene
Gene symbol

CASKIN2

PDE2A

Gene ID

57513

5138

Gene nameCASK interacting protein 2phosphodiesterase 2A
SynonymsANKS5BCGS-PDE|PDE2A1|PED2A4|cGSPDE
Cytomap

17q25.1

11q13.4

Type of geneprotein-codingprotein-coding
Descriptioncaskin-2cGMP-dependent 3',5'-cyclic phosphodiesterasecGMP-stimulated phosphodiesterase 1cGMP-stimulated phosphodiesterase 2cGMP-stimulated phosphodiesterase 4cyclic GMP-stimulated phosphodiesterasephosphodiesterase 2A, cGMP-stimulated
Modification date2020031320200313
UniProtAcc

Q8WXE0

.
Ensembl transtripts involved in fusion geneENST00000321617, ENST00000433559, 
ENST00000581870, 		ENST00000334456, 
ENST00000376450, ENST00000444035, 
ENST00000544570, ENST00000418754, 
ENST00000540345, ENST00000540380, 
Fusion gene scores* DoF score3 X 2 X 3=1811 X 7 X 7=539
# samples 312
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/539*10)=-2.16725086714399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CASKIN2 [Title/Abstract] AND PDE2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCASKIN2(73509792)-PDE2A(72353370), # samples:1
Anticipated loss of major functional domain due to fusion event.CASKIN2-PDE2A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CASKIN2-PDE2A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CASKIN2-PDE2A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CASKIN2-PDE2A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDE2A

GO:0000122

negative regulation of transcription by RNA polymerase II

17329248

TgenePDE2A

GO:0007193

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

17329248

TgenePDE2A

GO:0036006

cellular response to macrophage colony-stimulating factor stimulus

14687666

TgenePDE2A

GO:0046069

cGMP catabolic process

19828435

TgenePDE2A

GO:0071320

cellular response to cAMP

17329248

TgenePDE2A

GO:0071321

cellular response to cGMP

17704206|19828435

TgenePDE2A

GO:1904613

cellular response to 2,3,7,8-tetrachlorodibenzodioxine

17329248


check buttonFusion gene breakpoints across CASKIN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PDE2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A8SF-01ACASKIN2chr17

73509792

-PDE2Achr11

72353370

-


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Fusion Gene ORF analysis for CASKIN2-PDE2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000321617ENST00000334456CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
In-frameENST00000321617ENST00000376450CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
Frame-shiftENST00000321617ENST00000444035CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
In-frameENST00000321617ENST00000544570CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
Frame-shiftENST00000321617ENST00000418754CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
Frame-shiftENST00000321617ENST00000540345CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
5CDS-intronENST00000321617ENST00000540380CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
intron-3CDSENST00000433559ENST00000334456CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
intron-3CDSENST00000433559ENST00000376450CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
intron-3CDSENST00000433559ENST00000444035CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
intron-3CDSENST00000433559ENST00000544570CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
intron-3CDSENST00000433559ENST00000418754CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
intron-3CDSENST00000433559ENST00000540345CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
intron-intronENST00000433559ENST00000540380CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
Frame-shiftENST00000581870ENST00000334456CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
In-frameENST00000581870ENST00000376450CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
Frame-shiftENST00000581870ENST00000444035CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
In-frameENST00000581870ENST00000544570CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
Frame-shiftENST00000581870ENST00000418754CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
Frame-shiftENST00000581870ENST00000540345CASKIN2chr17

73509792

-PDE2Achr11

72353370

-
5CDS-intronENST00000581870ENST00000540380CASKIN2chr17

73509792

-PDE2Achr11

72353370

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000321617CASKIN2chr1773509792-ENST00000376450PDE2Achr1172353370-39316811224424266
ENST00000321617CASKIN2chr1773509792-ENST00000544570PDE2Achr1172353370-36666812331009258
ENST00000581870CASKIN2chr1773509792-ENST00000376450PDE2Achr1172353370-37885381081281266
ENST00000581870CASKIN2chr1773509792-ENST00000544570PDE2Achr1172353370-352353890866258

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000321617ENST00000376450CASKIN2chr1773509792-PDE2Achr1172353370-0.46452760.5354724
ENST00000321617ENST00000544570CASKIN2chr1773509792-PDE2Achr1172353370-0.195205780.80479425
ENST00000581870ENST00000376450CASKIN2chr1773509792-PDE2Achr1172353370-0.45398670.5460133
ENST00000581870ENST00000544570CASKIN2chr1773509792-PDE2Achr1172353370-0.17811390.82188606

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Fusion Genomic Features for CASKIN2-PDE2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CASKIN2-PDE2A


check button Go to

FGviewer for the breakpoints of chr17:73509792-chr11:72353370

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CASKIN2

Q8WXE0

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDE2Achr17:73509792chr11:72353370ENST00000334456031241_37723.666666666666668942.0DomainGAF 1
TgenePDE2Achr17:73509792chr11:72353370ENST00000334456031409_54823.666666666666668942.0DomainGAF 2
TgenePDE2Achr17:73509792chr11:72353370ENST00000334456031578_90223.666666666666668942.0DomainPDEase
TgenePDE2Achr17:73509792chr11:72353370ENST00000444035031241_37714.666666666666666933.0DomainGAF 1
TgenePDE2Achr17:73509792chr11:72353370ENST00000444035031409_54814.666666666666666933.0DomainGAF 2
TgenePDE2Achr17:73509792chr11:72353370ENST00000444035031578_90214.666666666666666933.0DomainPDEase
TgenePDE2Achr17:73509792chr11:72353370ENST00000540345132241_37714.666666666666666933.0DomainGAF 1
TgenePDE2Achr17:73509792chr11:72353370ENST00000540345132409_54814.666666666666666933.0DomainGAF 2
TgenePDE2Achr17:73509792chr11:72353370ENST00000540345132578_90214.666666666666666933.0DomainPDEase
TgenePDE2Achr17:73509792chr11:72353370ENST00000334456031656_66023.666666666666668942.0RegionNote=Substrate binding
TgenePDE2Achr17:73509792chr11:72353370ENST00000444035031656_66014.666666666666666933.0RegionNote=Substrate binding
TgenePDE2Achr17:73509792chr11:72353370ENST00000540345132656_66014.666666666666666933.0RegionNote=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000321617-220685_113331.3333333333333321203.0Compositional biasNote=Pro-rich
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000433559-119685_113301121.0Compositional biasNote=Pro-rich
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000321617-220281_34731.3333333333333321203.0DomainSH3
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000321617-220489_55231.3333333333333321203.0DomainSAM 1
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000321617-220558_62231.3333333333333321203.0DomainSAM 2
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000433559-119281_34701121.0DomainSH3
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000433559-119489_55201121.0DomainSAM 1
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000433559-119558_62201121.0DomainSAM 2
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000321617-220114_14331.3333333333333321203.0RepeatNote=ANK 3
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000321617-220147_17631.3333333333333321203.0RepeatNote=ANK 4
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000321617-220188_21731.3333333333333321203.0RepeatNote=ANK 5
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000321617-220220_24931.3333333333333321203.0RepeatNote=ANK 6
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000321617-22048_7731.3333333333333321203.0RepeatNote=ANK 1
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000321617-22081_11031.3333333333333321203.0RepeatNote=ANK 2
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000433559-119114_14301121.0RepeatNote=ANK 3
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000433559-119147_17601121.0RepeatNote=ANK 4
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000433559-119188_21701121.0RepeatNote=ANK 5
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000433559-119220_24901121.0RepeatNote=ANK 6
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000433559-11948_7701121.0RepeatNote=ANK 1
HgeneCASKIN2chr17:73509792chr11:72353370ENST00000433559-11981_11001121.0RepeatNote=ANK 2


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Fusion Gene Sequence for CASKIN2-PDE2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000321617_ENST00000376450_TCGA-YL-A8SF-01A_CASKIN2_chr17_73509792_-_PDE2A_chr11_72353370_length(transcript)=3931nt_BP=681nt
GACGGTCCCTCCGTTCCCGATCCGGCGGGAGGGAGGGGGGAGGGGCGGGATTTCCTGCGGGAGGCGCCGAGCCGGCCTTGGAAAAGGAGA
AGGAGAAAGGGGGGCAGGGGGGAGTGGGAGCCACCGTCCTGAGTGCCAGGGACCGAGCAGGGCCAGCCGGACCCCGGCGGGCGGCCGGGA
GAGAGCCCTGAGACCAGTGCACCGCTGCTGCCTGAGGCCCAAGGGAATGCTGGCTGCTCTCTGGGTGGGCACTGGTGTTCCACAGCCAAG
CCGGGAAGATTGGTGTGCCCAGTCCCAGCCCATCCTGGAGCTGTCGGAAGCCACAAGCTGATATCCATCCAGATTTCCATGTAGCCTTCA
CCCCCTCAAAGATTAGCTTTCCTTCGTGTGGTGGCAGTTCACGGAGCACCTTTGGGAGTATCCCTCAGTACCTGACGAGGAGCCCACTGC
CTGGGACACCTGACTTGCTCCCCCGGAACCGGGAGCCCTCCAAGGGGCTGTGGCATGGCGCCCTGACGCCCCAGCTTGGACCCGTTGCCT
GCCTTTGCCCTGGACTCCTGAGTGTAGAGCTCAGCCCAGGAGCCAGTATGGGTCGTGAACAGGACCTGATCCTCGCCGTCAAGAATGGAG
ATGTGACCGGTGTGCAGAAACTGGTGGCGAAGGTCAAGGCCACAAAGACAAGCTGTTGCAGGACCTGTTCCCCAAAGCGGCAGAGCTGTA
CGAGCGCGTGGCCTCCAACCGTGAGCACTGGACCAAGGTGTCCCACAAGTTCACCATCCGCGGCCTCCCAAGTAACAACTCGCTGGACTT
CCTGGATGAGGAGTACGAGGTGCCTGATCTGGATGGCACTAGGGCCCCCATCAATGGCTGCTGCAGCCTTGATGCTGAGTGATCCCCTCC
AGGGACACTTCCCTGCCCAGGCCACCTCCCACAGCCCTCCACTGGTCTGGCCAGATGCACTGGGAACAGAGCCACGGGTCCTGGGTCCTA
GACCAGGACTTCCTGTGTGACCCTGGACAAGTACTACCTTCCTGGGCCTCAGCTTTCTCGTCTGTATAATGGAAGCAAGACTTCCAACCT
CACGGAGACTTTGTAATTTGTTTTCTGAGAGCACAGGGGTGACCAATGAGCAGTGGGCCCTACTCTGCACCTCTGACCACACCTTGGCAA
GTCTTTCCCAAGCCATTCTTTGTCTGAGCAGCTTGATGGTTTCTCCTTGCCCCATTTCTGCCCCACCAGATCTTTGCTCCTTTCCCTTTG
AGGACTCCCACCCTTTGGGGTCTCCAGGATCCTCATGGAAGGGGAAGGTGAGACATCTGAGTGAGCAGAGTGTGGCATCTTGGAAACAGT
CCTTAGTTCTGTGGGAGGACTAGAAACAGCCGCGGGGCGAAGGCCCCCTGAGGACCACTACTATACTGATGGTGGGATTGGGACCTGGGG
GATACAGGGGCCCCAGGAAGAAGCTGCCAGAGGGGCAGCTCAGTGCTCTGCAGAGAGGGGCCCTGGGGAGAAGCAGGATGGGATTGATGG
GCAGGAGGGATCCCCGCACTGGGAGACAGGCCCAGGTATGAATGAGCCAGCCATGCTTCCTCCTGCCTGTGTGACGCTGGGCGAGTCTCT
TCCCCTGTCTGGGCCAAACAGGGAGCGGGTAAGACAATCCATGCTCTAAGATCCATTTTAGATCAATGTCTAAAATAGCTCTATCGCTCT
GCGGAGTCCCAGCAGAGGCTATGGAATGTTTCTGCAACCCTAAGGCACAGAGAGCCCAACCCTGAGTGTCTCAGAGGCCCCCTGAGTGTT
CCCCTTGGCCTGAGCCCCTTACCCATTCCTGCAGCCAGTGAGAGACCTGGCCTCAGCCCTGGCAGGGCTCTCTCTTCAAGGCCATATCCA
CCTGTGCCCTGGGGCTTGGGAGACCCCATAGGGCCGGGACTCTTGGGTCAGCCCGGCCACTGGCTTCTCTCTTTTTCTCTGTTTCATTCT
GTGTGCGTTGTGGGGTGGGGGAGGGGGTCCACCTGCCTTACCTTTCTGAGTTGCCTTTAGAGAGATGCGTTTTTCTAGGACTCTGTGCAA
CTGTCGTATATGGTCCCGTGGGCTGACCGCTTTGTACATGAGAATAAATCTATTTCTTTCTACCGAGAAGGCCATGGGCAACAGGCCGAT
GGAGATGATGGACCGGGAGAAGGCCTATATCCCTGAGCTGCAAATCAGCTTCATGGAGCACATTGCAATGCCCATCTACAAGAGCTGATC
TACAAAGAATTCTTCTCCCAGGGAGACCTGTGGGCTACGACCGAAACAACAAGCAGCACCACAGACTTCTCCTCTGCCTCCTCATGACCT
CCTGTGACCTCTCTGACCAGACCAAGGGCTGGAAGACTACGAGAAAGATCGCGGACTATCAGCGCATGCTGGATCTGATGCGGGACATCA
TCTTGGCCACAGACCTGGCCCACCATCTCCGCATCTTCAAGGACCTCCAGAAGATGGCTGAGGAGGCACCACTTTGCTCAGGCCATCGCC
ATCCTCAACACCCACGGCTGCAACATCTTTGATCATTTCTCCCGGAAGAAATCTGTGCTGGCTGCGCTCTACAGCTCTGAGGGCTCCGTC
ATGGAGGGACATCGAGATCTTTGCCTTGTTTATTTCCTGCATGTGTCATGACCTGGACCACAGAGGCACAAACAACTCTTTCCAGGTGGC
CTCGGTTCTGTTTGATGGTGAAGAAGGGCTACCGGGATCCCCCCTACCACAACTGGATGCACGCCTTTTCTGTCTCCCACTTCTGCTACC
TGCTCTACAAGAACCTGGAGCTCACCAACTACCTCGAGCCATCCTGAGCATGCTGCAGGACATGAATTTCATCAACAACTACAAAATTGA
CTGCCCGACCCTGGCCCGGTCTCCGATGATGAGTATACCAAACTTCTCCATGATGGGATCCAGCCTGTGGCTGCCATTGACTCCAATTTT
GCAAGTTTCACCTATACCCCTCGTTCCCTGCCCGAGGATGACACGTCCATGTCTCTCCTATACAAAAAAGTGAATGAGGCTCAGTATCGC
AGCCACCTGGCCAATGAGATGATGATGTACCACATGAAGAGGTCATCGGTGTGGCCGAGCTGGTGAACAAGATCAATGGGCCATGGTTCA
GCAAGTTCGACGAGGACCTGGCGACGGCCTTCTCCATCTACTGCGGCATCAGCATCGCCCATAGCTATGAGATCCGCATCCCGGCCGATC
AGGGCATCGCGGGACACGTGGCGACCACGGGCCAGATCCTGAACATCCCTGACGCATATGCCCATCCGCTTTTCTACCGCGGCGTGGACG
ACAGCACCGGCTTCCGCACGCGCAACATCCTCTGCTTCCCCATCAAGAACGAGAACCAGGCTGCTCTGTGTTCCTGCTGGATCAGAATGA
GCTGGTGGCCAAGGTGTTCGACGGGGGCGTGGTGGATGATGAGATGACGTCTCTGTCCTGCTCCAGGAGATCATCACGGAGGCCAGAAAC
CTCAGCAACGCAGAGATGCTCTTCTCCAAGTGGCAAAGAACCTCTTCACCCACCTGGGTTCACCGACGAGGACGAGCATGTGATCCAGCA
CTGCTTCCACTACACCAGCACCGTGCTCACCAGCACCCTGGCCTTCCAGAAGGAACAGAAACTCAAGTGTGAGTGCCAGGAAACTGTCTA
CACCTACCTACTGGATGGTGAGTCCCAGCTGGTGTGTGAGGACCCCCCACATGAGCTGCCCCAGGAGGGGAAAGTCCGGACGCCTTGCTG
AGTCTGGGCTCTGTCATCGACATTTCAGGCCTGCAACGTGCTGTCAAGGAGGCCCTGTCAGCTGTGCTCCCCCGAGTGGCGGGGCCAGCA

>In-frame_ENST00000321617_ENST00000376450_TCGA-YL-A8SF-01A_CASKIN2_chr17_73509792_-_PDE2A_chr11_72353370_length(amino acids)=266AA_start in transcript=1224_stop in transcript=424
MGQGETIKLLRQRMAWERLAKVWSEVQSRAHCSLVTPVLSENKLQSLREVGSLASIIQTRKLRPRKVVLVQGHTGSPGLGPRTRGSVPSA
SGQTSGGLWEVAWAGKCPWRGSLSIKAAAAIDGGPSAIQIRHLVLLIQEVQRVVTWEAADGELVGHLGPVLTVGGHALVQLCRFGEQVLQ

--------------------------------------------------------------
>In-frame_ENST00000321617_ENST00000544570_TCGA-YL-A8SF-01A_CASKIN2_chr17_73509792_-_PDE2A_chr11_72353370_length(transcript)=3666nt_BP=681nt
GACGGTCCCTCCGTTCCCGATCCGGCGGGAGGGAGGGGGGAGGGGCGGGATTTCCTGCGGGAGGCGCCGAGCCGGCCTTGGAAAAGGAGA
AGGAGAAAGGGGGGCAGGGGGGAGTGGGAGCCACCGTCCTGAGTGCCAGGGACCGAGCAGGGCCAGCCGGACCCCGGCGGGCGGCCGGGA
GAGAGCCCTGAGACCAGTGCACCGCTGCTGCCTGAGGCCCAAGGGAATGCTGGCTGCTCTCTGGGTGGGCACTGGTGTTCCACAGCCAAG
CCGGGAAGATTGGTGTGCCCAGTCCCAGCCCATCCTGGAGCTGTCGGAAGCCACAAGCTGATATCCATCCAGATTTCCATGTAGCCTTCA
CCCCCTCAAAGATTAGCTTTCCTTCGTGTGGTGGCAGTTCACGGAGCACCTTTGGGAGTATCCCTCAGTACCTGACGAGGAGCCCACTGC
CTGGGACACCTGACTTGCTCCCCCGGAACCGGGAGCCCTCCAAGGGGCTGTGGCATGGCGCCCTGACGCCCCAGCTTGGACCCGTTGCCT
GCCTTTGCCCTGGACTCCTGAGTGTAGAGCTCAGCCCAGGAGCCAGTATGGGTCGTGAACAGGACCTGATCCTCGCCGTCAAGAATGGAG
ATGTGACCGGTGTGCAGAAACTGGTGGCGAAGGTCAAGGCCACAAAGACAAGCTGTTGCAGGACCTGTTCCCCAAAGCGGCAGAGCTGTA
CGAGCGCGTGGCCTCCAACCGTGAGCACTGGACCAAGGTGTCCCACAAGTTCACCATCCGCGGCCTCCCAAGTAACAACTCGCTGGACTT
CCTGGATGAGGAGTACGAGGTGCCTGATCTGGATGGCACTAGGGCCCCCATCAATGGCTGCTGCAGCCTTGATGCTGAGTGATCCCCTCC
AGGGACACTTCCCTGCCCAGGCCACCTCCCACAGCCCTCCACTGGTCTGGCCAGATGCACTGGGAACAGAGCCACGGGTCCTGGGTCCTA
GACCAGGACTTCCTGTGTGACCCTGGACAAGTACTACCTTCCTGGGCCTCAGCTTTCTCGTCTGTATAATGGAAGCAAGACTTCCAACCT
CACGGAGACTTTGTAATTTGTTTTCTGAGAGCACAGGGGTGAGAGAAGGCCATGGGCAACAGGCCGATGGAGATGATGGACCGGGAGAAG
GCCTATATCCCTGAGCTGCAAATCAGCTTCATGGAGCACATTGCAATGCCCATCTACAAGAGCTGATCTACAAAGAATTCTTCTCCCAGG
GAGACCTGTGGGCTACGACCGAAACAACAAGCAGCACCACAGACTTCTCCTCTGCCTCCTCATGACCTCCTGTGACCTCTCTGACCAGAC
CAAGGGCTGGAAGACTACGAGAAAGATCGCGGACTATCAGCGCATGCTGGATCTGATGCGGGACATCATCTTGGCCACAGACCTGGCCCA
CCATCTCCGCATCTTCAAGGACCTCCAGAAGATGGCTGAGGAGGCACCACTTTGCTCAGGCCATCGCCATCCTCAACACCCACGGCTGCA
ACATCTTTGATCATTTCTCCCGGAAGAAATCTGTGCTGGCTGCGCTCTACAGCTCTGAGGGCTCCGTCATGGAGGGACATCGAGATCTTT
GCCTTGTTTATTTCCTGCATGTGTCATGACCTGGACCACAGAGGCACAAACAACTCTTTCCAGGTGGCCTCGGTTCTGTTTGATGGTGAA
GAAGGGCTACCGGGATCCCCCCTACCACAACTGGATGCACGCCTTTTCTGTCTCCCACTTCTGCTACCTGCTCTACAAGAACCTGGAGCT
CACCAACTACCTCGAGCCATCCTGAGCATGCTGCAGGACATGAATTTCATCAACAACTACAAAATTGACTGCCCGACCCTGGCCCGGTCT
CCGATGATGAGTATACCAAACTTCTCCATGATGGGATCCAGCCTGTGGCTGCCATTGACTCCAATTTTGCAAGTTTCACCTATACCCCTC
GTTCCCTGCCCGAGGATGACACGTCCATGTCTCTCCTATACAAAAAAGTGAATGAGGCTCAGTATCGCAGCCACCTGGCCAATGAGATGA
TGATGTACCACATGAAGAGGTCATCGGTGTGGCCGAGCTGGTGAACAAGATCAATGGGCCATGGTTCAGCAAGTTCGACGAGGACCTGGC
GACGGCCTTCTCCATCTACTGCGGCATCAGCATCGCCCATAGCTATGAGATCCGCATCCCGGCCGATCAGGGCATCGCGGGACACGTGGC
GACCACGGGCCAGATCCTGAACATCCCTGACGCATATGCCCATCCGCTTTTCTACCGCGGCGTGGACGACAGCACCGGCTTCCGCACGCG
CAACATCCTCTGCTTCCCCATCAAGAACGAGAACCAGGCTGCTCTGTGTTCCTGCTGGATCAGAATGAGCTGGTGGCCAAGGTGTTCGAC
GGGGGCGTGGTGGATGATGAGATGACGTCTCTGTCCTGCTCCAGGAGATCATCACGGAGGCCAGAAACCTCAGCAACGCAGAGATGCTCT
TCTCCAAGTGGCAAAGAACCTCTTCACCCACCTGGGTTCACCGACGAGGACGAGCATGTGATCCAGCACTGCTTCCACTACACCAGCACC
GTGCTCACCAGCACCCTGGCCTTCCAGAAGGAACAGAAACTCAAGTGTGAGTGCCAGGAGGATGTACAACAGCTGCAGAGCATGTTGGGC
TGTGAGCTGCAGGCCATGCTCTGTGTCCCTGTCATCAGCCGGGCCACTGACCAGGTGGTGGCCTTGGCCTGCGCCTTCAACAAGCTAGAA
GGAGACTTTTGACAGGATGCCTGGGCCAGGTGGTGGAAGACAAGAAGTCCATCCAGCTGAAGGACCTCACCTCCGTCATCGGAGACAAAG
TGCTCGGGGAAGAGGTCAGCTTTCCCCTGCAGCAGGAGACCCGGGCATCCCGCTGCTGCCTCCTGCTGGTGTCGGAGGACAATCTCCAGC
TTTCTTGCAAGGGGAACTCTACGACCTGGATGCCTCTTCCCTGCAGCTCAAAGTGCTCCAATACACCCTGGTCGCCCTGCGGAGGGTGCA
GGTCCTGCAGCAGCGCGGGCCCAGGGAGGCTCCCCGAGCCGTCCAGAACCCCCCGGAGGGGACGGCGGAAGACCAGAAGGGCGGGGCGGC
GTACACCGACCGCGACCGCAAGATCCTCCAACTGTGCGGTGCACTGTGGCCAGCTGAGTGATAATGAGGAATGGAGCCTGCAGGCGGTGG
AGAAGCATTGCTGGTCATGCCGCTAGCGGACAAGGAGGCTGGGGCCGTGGCAGCTGTCATCTTGGGAGGCTATCATCTCCCAGAAGCGGC
TGGGCTGCAATGGGCTGGGCTTCTCAGACCTGCCAGGGAAGCCCTTGGCCAGGCTGGTGGCTCCACTGGCTCCTGATACCCAAGGAAACT
GTCTACACCTACCTACTGGATGGTGAGTCCCAGCTGGTGTGTGAGGACCCCCCACATGAGCTGCCCCAGGAGGGGAAAGTCCGGACGCCT
TGCTGAGTCTGGGCTCTGTCATCGACATTTCAGGCCTGCAACGTGCTGTCAAGGAGGCCCTGTCAGCTGTGCTCCCCCGAGTGGCGGGGC

>In-frame_ENST00000321617_ENST00000544570_TCGA-YL-A8SF-01A_CASKIN2_chr17_73509792_-_PDE2A_chr11_72353370_length(amino acids)=258AA_start in transcript=233_stop in transcript=1009
MLSGWALVFHSQAGKIGVPSPSPSWSCRKPQADIHPDFHVAFTPSKISFPSCGGSSRSTFGSIPQYLTRSPLPGTPDLLPRNREPSKGLW
HGALTPQLGPVACLCPGLLSVELSPGASMGREQDLILAVKNGDVTGVQKLVAKVKATKTSCCRTCSPKRQSCTSAWPPTVSTGPRCPTSS

--------------------------------------------------------------
>In-frame_ENST00000581870_ENST00000376450_TCGA-YL-A8SF-01A_CASKIN2_chr17_73509792_-_PDE2A_chr11_72353370_length(transcript)=3788nt_BP=538nt
CGAGCAGGGCCAGCCGGACCCCGGCGGGCGGCCGGGAGAGAGCCCTGAGACCAGTGCACCGCTGCTGCCTGAGGCCCAAGGGAATGCTGG
CTGCTCTCTGGGTGGGCACTGGTGTTCCACAGCCAAGCCGGGAAGATTGGTGTGCCCAGTCCCAGCCCATCCTGGAGCTGTCGGAAGCCA
CAAGCTGATATCCATCCAGATTTCCATGTAGCCTTCACCCCCTCAAAGATTAGCTTTCCTTCGTGTGGTGGCAGTTCACGGAGCACCTTT
GGGAGTATCCCTCAGTACCTGACGAGGAGCCCACTGCCTGGGACACCTGACTTGCTCCCCCGGAACCGGGAGCCCTCCAAGGGGCTGTGG
CATGGCGCCCTGACGCCCCAGCTTGGACCCGTTGCCTGCCTTTGCCCTGGACTCCTGAGTGTAGAGCTCAGCCCAGGAGCCAGTATGGGT
CGTGAACAGGACCTGATCCTCGCCGTCAAGAATGGAGATGTGACCGGTGTGCAGAAACTGGTGGCGAAGGTCAAGGCCACAAAGACAAGC
TGTTGCAGGACCTGTTCCCCAAAGCGGCAGAGCTGTACGAGCGCGTGGCCTCCAACCGTGAGCACTGGACCAAGGTGTCCCACAAGTTCA
CCATCCGCGGCCTCCCAAGTAACAACTCGCTGGACTTCCTGGATGAGGAGTACGAGGTGCCTGATCTGGATGGCACTAGGGCCCCCATCA
ATGGCTGCTGCAGCCTTGATGCTGAGTGATCCCCTCCAGGGACACTTCCCTGCCCAGGCCACCTCCCACAGCCCTCCACTGGTCTGGCCA
GATGCACTGGGAACAGAGCCACGGGTCCTGGGTCCTAGACCAGGACTTCCTGTGTGACCCTGGACAAGTACTACCTTCCTGGGCCTCAGC
TTTCTCGTCTGTATAATGGAAGCAAGACTTCCAACCTCACGGAGACTTTGTAATTTGTTTTCTGAGAGCACAGGGGTGACCAATGAGCAG
TGGGCCCTACTCTGCACCTCTGACCACACCTTGGCAAGTCTTTCCCAAGCCATTCTTTGTCTGAGCAGCTTGATGGTTTCTCCTTGCCCC
ATTTCTGCCCCACCAGATCTTTGCTCCTTTCCCTTTGAGGACTCCCACCCTTTGGGGTCTCCAGGATCCTCATGGAAGGGGAAGGTGAGA
CATCTGAGTGAGCAGAGTGTGGCATCTTGGAAACAGTCCTTAGTTCTGTGGGAGGACTAGAAACAGCCGCGGGGCGAAGGCCCCCTGAGG
ACCACTACTATACTGATGGTGGGATTGGGACCTGGGGGATACAGGGGCCCCAGGAAGAAGCTGCCAGAGGGGCAGCTCAGTGCTCTGCAG
AGAGGGGCCCTGGGGAGAAGCAGGATGGGATTGATGGGCAGGAGGGATCCCCGCACTGGGAGACAGGCCCAGGTATGAATGAGCCAGCCA
TGCTTCCTCCTGCCTGTGTGACGCTGGGCGAGTCTCTTCCCCTGTCTGGGCCAAACAGGGAGCGGGTAAGACAATCCATGCTCTAAGATC
CATTTTAGATCAATGTCTAAAATAGCTCTATCGCTCTGCGGAGTCCCAGCAGAGGCTATGGAATGTTTCTGCAACCCTAAGGCACAGAGA
GCCCAACCCTGAGTGTCTCAGAGGCCCCCTGAGTGTTCCCCTTGGCCTGAGCCCCTTACCCATTCCTGCAGCCAGTGAGAGACCTGGCCT
CAGCCCTGGCAGGGCTCTCTCTTCAAGGCCATATCCACCTGTGCCCTGGGGCTTGGGAGACCCCATAGGGCCGGGACTCTTGGGTCAGCC
CGGCCACTGGCTTCTCTCTTTTTCTCTGTTTCATTCTGTGTGCGTTGTGGGGTGGGGGAGGGGGTCCACCTGCCTTACCTTTCTGAGTTG
CCTTTAGAGAGATGCGTTTTTCTAGGACTCTGTGCAACTGTCGTATATGGTCCCGTGGGCTGACCGCTTTGTACATGAGAATAAATCTAT
TTCTTTCTACCGAGAAGGCCATGGGCAACAGGCCGATGGAGATGATGGACCGGGAGAAGGCCTATATCCCTGAGCTGCAAATCAGCTTCA
TGGAGCACATTGCAATGCCCATCTACAAGAGCTGATCTACAAAGAATTCTTCTCCCAGGGAGACCTGTGGGCTACGACCGAAACAACAAG
CAGCACCACAGACTTCTCCTCTGCCTCCTCATGACCTCCTGTGACCTCTCTGACCAGACCAAGGGCTGGAAGACTACGAGAAAGATCGCG
GACTATCAGCGCATGCTGGATCTGATGCGGGACATCATCTTGGCCACAGACCTGGCCCACCATCTCCGCATCTTCAAGGACCTCCAGAAG
ATGGCTGAGGAGGCACCACTTTGCTCAGGCCATCGCCATCCTCAACACCCACGGCTGCAACATCTTTGATCATTTCTCCCGGAAGAAATC
TGTGCTGGCTGCGCTCTACAGCTCTGAGGGCTCCGTCATGGAGGGACATCGAGATCTTTGCCTTGTTTATTTCCTGCATGTGTCATGACC
TGGACCACAGAGGCACAAACAACTCTTTCCAGGTGGCCTCGGTTCTGTTTGATGGTGAAGAAGGGCTACCGGGATCCCCCCTACCACAAC
TGGATGCACGCCTTTTCTGTCTCCCACTTCTGCTACCTGCTCTACAAGAACCTGGAGCTCACCAACTACCTCGAGCCATCCTGAGCATGC
TGCAGGACATGAATTTCATCAACAACTACAAAATTGACTGCCCGACCCTGGCCCGGTCTCCGATGATGAGTATACCAAACTTCTCCATGA
TGGGATCCAGCCTGTGGCTGCCATTGACTCCAATTTTGCAAGTTTCACCTATACCCCTCGTTCCCTGCCCGAGGATGACACGTCCATGTC
TCTCCTATACAAAAAAGTGAATGAGGCTCAGTATCGCAGCCACCTGGCCAATGAGATGATGATGTACCACATGAAGAGGTCATCGGTGTG
GCCGAGCTGGTGAACAAGATCAATGGGCCATGGTTCAGCAAGTTCGACGAGGACCTGGCGACGGCCTTCTCCATCTACTGCGGCATCAGC
ATCGCCCATAGCTATGAGATCCGCATCCCGGCCGATCAGGGCATCGCGGGACACGTGGCGACCACGGGCCAGATCCTGAACATCCCTGAC
GCATATGCCCATCCGCTTTTCTACCGCGGCGTGGACGACAGCACCGGCTTCCGCACGCGCAACATCCTCTGCTTCCCCATCAAGAACGAG
AACCAGGCTGCTCTGTGTTCCTGCTGGATCAGAATGAGCTGGTGGCCAAGGTGTTCGACGGGGGCGTGGTGGATGATGAGATGACGTCTC
TGTCCTGCTCCAGGAGATCATCACGGAGGCCAGAAACCTCAGCAACGCAGAGATGCTCTTCTCCAAGTGGCAAAGAACCTCTTCACCCAC
CTGGGTTCACCGACGAGGACGAGCATGTGATCCAGCACTGCTTCCACTACACCAGCACCGTGCTCACCAGCACCCTGGCCTTCCAGAAGG
AACAGAAACTCAAGTGTGAGTGCCAGGAAACTGTCTACACCTACCTACTGGATGGTGAGTCCCAGCTGGTGTGTGAGGACCCCCCACATG
AGCTGCCCCAGGAGGGGAAAGTCCGGACGCCTTGCTGAGTCTGGGCTCTGTCATCGACATTTCAGGCCTGCAACGTGCTGTCAAGGAGGC
CCTGTCAGCTGTGCTCCCCCGAGTGGCGGGGCCAGCAGGTCTTCCTCAAGCCGGACGAGCCGCCGCCGCCGCCGCAGCCATGCGCCGACA

>In-frame_ENST00000581870_ENST00000376450_TCGA-YL-A8SF-01A_CASKIN2_chr17_73509792_-_PDE2A_chr11_72353370_length(amino acids)=266AA_start in transcript=1081_stop in transcript=281
MGQGETIKLLRQRMAWERLAKVWSEVQSRAHCSLVTPVLSENKLQSLREVGSLASIIQTRKLRPRKVVLVQGHTGSPGLGPRTRGSVPSA
SGQTSGGLWEVAWAGKCPWRGSLSIKAAAAIDGGPSAIQIRHLVLLIQEVQRVVTWEAADGELVGHLGPVLTVGGHALVQLCRFGEQVLQ

--------------------------------------------------------------
>In-frame_ENST00000581870_ENST00000544570_TCGA-YL-A8SF-01A_CASKIN2_chr17_73509792_-_PDE2A_chr11_72353370_length(transcript)=3523nt_BP=538nt
CGAGCAGGGCCAGCCGGACCCCGGCGGGCGGCCGGGAGAGAGCCCTGAGACCAGTGCACCGCTGCTGCCTGAGGCCCAAGGGAATGCTGG
CTGCTCTCTGGGTGGGCACTGGTGTTCCACAGCCAAGCCGGGAAGATTGGTGTGCCCAGTCCCAGCCCATCCTGGAGCTGTCGGAAGCCA
CAAGCTGATATCCATCCAGATTTCCATGTAGCCTTCACCCCCTCAAAGATTAGCTTTCCTTCGTGTGGTGGCAGTTCACGGAGCACCTTT
GGGAGTATCCCTCAGTACCTGACGAGGAGCCCACTGCCTGGGACACCTGACTTGCTCCCCCGGAACCGGGAGCCCTCCAAGGGGCTGTGG
CATGGCGCCCTGACGCCCCAGCTTGGACCCGTTGCCTGCCTTTGCCCTGGACTCCTGAGTGTAGAGCTCAGCCCAGGAGCCAGTATGGGT
CGTGAACAGGACCTGATCCTCGCCGTCAAGAATGGAGATGTGACCGGTGTGCAGAAACTGGTGGCGAAGGTCAAGGCCACAAAGACAAGC
TGTTGCAGGACCTGTTCCCCAAAGCGGCAGAGCTGTACGAGCGCGTGGCCTCCAACCGTGAGCACTGGACCAAGGTGTCCCACAAGTTCA
CCATCCGCGGCCTCCCAAGTAACAACTCGCTGGACTTCCTGGATGAGGAGTACGAGGTGCCTGATCTGGATGGCACTAGGGCCCCCATCA
ATGGCTGCTGCAGCCTTGATGCTGAGTGATCCCCTCCAGGGACACTTCCCTGCCCAGGCCACCTCCCACAGCCCTCCACTGGTCTGGCCA
GATGCACTGGGAACAGAGCCACGGGTCCTGGGTCCTAGACCAGGACTTCCTGTGTGACCCTGGACAAGTACTACCTTCCTGGGCCTCAGC
TTTCTCGTCTGTATAATGGAAGCAAGACTTCCAACCTCACGGAGACTTTGTAATTTGTTTTCTGAGAGCACAGGGGTGAGAGAAGGCCAT
GGGCAACAGGCCGATGGAGATGATGGACCGGGAGAAGGCCTATATCCCTGAGCTGCAAATCAGCTTCATGGAGCACATTGCAATGCCCAT
CTACAAGAGCTGATCTACAAAGAATTCTTCTCCCAGGGAGACCTGTGGGCTACGACCGAAACAACAAGCAGCACCACAGACTTCTCCTCT
GCCTCCTCATGACCTCCTGTGACCTCTCTGACCAGACCAAGGGCTGGAAGACTACGAGAAAGATCGCGGACTATCAGCGCATGCTGGATC
TGATGCGGGACATCATCTTGGCCACAGACCTGGCCCACCATCTCCGCATCTTCAAGGACCTCCAGAAGATGGCTGAGGAGGCACCACTTT
GCTCAGGCCATCGCCATCCTCAACACCCACGGCTGCAACATCTTTGATCATTTCTCCCGGAAGAAATCTGTGCTGGCTGCGCTCTACAGC
TCTGAGGGCTCCGTCATGGAGGGACATCGAGATCTTTGCCTTGTTTATTTCCTGCATGTGTCATGACCTGGACCACAGAGGCACAAACAA
CTCTTTCCAGGTGGCCTCGGTTCTGTTTGATGGTGAAGAAGGGCTACCGGGATCCCCCCTACCACAACTGGATGCACGCCTTTTCTGTCT
CCCACTTCTGCTACCTGCTCTACAAGAACCTGGAGCTCACCAACTACCTCGAGCCATCCTGAGCATGCTGCAGGACATGAATTTCATCAA
CAACTACAAAATTGACTGCCCGACCCTGGCCCGGTCTCCGATGATGAGTATACCAAACTTCTCCATGATGGGATCCAGCCTGTGGCTGCC
ATTGACTCCAATTTTGCAAGTTTCACCTATACCCCTCGTTCCCTGCCCGAGGATGACACGTCCATGTCTCTCCTATACAAAAAAGTGAAT
GAGGCTCAGTATCGCAGCCACCTGGCCAATGAGATGATGATGTACCACATGAAGAGGTCATCGGTGTGGCCGAGCTGGTGAACAAGATCA
ATGGGCCATGGTTCAGCAAGTTCGACGAGGACCTGGCGACGGCCTTCTCCATCTACTGCGGCATCAGCATCGCCCATAGCTATGAGATCC
GCATCCCGGCCGATCAGGGCATCGCGGGACACGTGGCGACCACGGGCCAGATCCTGAACATCCCTGACGCATATGCCCATCCGCTTTTCT
ACCGCGGCGTGGACGACAGCACCGGCTTCCGCACGCGCAACATCCTCTGCTTCCCCATCAAGAACGAGAACCAGGCTGCTCTGTGTTCCT
GCTGGATCAGAATGAGCTGGTGGCCAAGGTGTTCGACGGGGGCGTGGTGGATGATGAGATGACGTCTCTGTCCTGCTCCAGGAGATCATC
ACGGAGGCCAGAAACCTCAGCAACGCAGAGATGCTCTTCTCCAAGTGGCAAAGAACCTCTTCACCCACCTGGGTTCACCGACGAGGACGA
GCATGTGATCCAGCACTGCTTCCACTACACCAGCACCGTGCTCACCAGCACCCTGGCCTTCCAGAAGGAACAGAAACTCAAGTGTGAGTG
CCAGGAGGATGTACAACAGCTGCAGAGCATGTTGGGCTGTGAGCTGCAGGCCATGCTCTGTGTCCCTGTCATCAGCCGGGCCACTGACCA
GGTGGTGGCCTTGGCCTGCGCCTTCAACAAGCTAGAAGGAGACTTTTGACAGGATGCCTGGGCCAGGTGGTGGAAGACAAGAAGTCCATC
CAGCTGAAGGACCTCACCTCCGTCATCGGAGACAAAGTGCTCGGGGAAGAGGTCAGCTTTCCCCTGCAGCAGGAGACCCGGGCATCCCGC
TGCTGCCTCCTGCTGGTGTCGGAGGACAATCTCCAGCTTTCTTGCAAGGGGAACTCTACGACCTGGATGCCTCTTCCCTGCAGCTCAAAG
TGCTCCAATACACCCTGGTCGCCCTGCGGAGGGTGCAGGTCCTGCAGCAGCGCGGGCCCAGGGAGGCTCCCCGAGCCGTCCAGAACCCCC
CGGAGGGGACGGCGGAAGACCAGAAGGGCGGGGCGGCGTACACCGACCGCGACCGCAAGATCCTCCAACTGTGCGGTGCACTGTGGCCAG
CTGAGTGATAATGAGGAATGGAGCCTGCAGGCGGTGGAGAAGCATTGCTGGTCATGCCGCTAGCGGACAAGGAGGCTGGGGCCGTGGCAG
CTGTCATCTTGGGAGGCTATCATCTCCCAGAAGCGGCTGGGCTGCAATGGGCTGGGCTTCTCAGACCTGCCAGGGAAGCCCTTGGCCAGG
CTGGTGGCTCCACTGGCTCCTGATACCCAAGGAAACTGTCTACACCTACCTACTGGATGGTGAGTCCCAGCTGGTGTGTGAGGACCCCCC
ACATGAGCTGCCCCAGGAGGGGAAAGTCCGGACGCCTTGCTGAGTCTGGGCTCTGTCATCGACATTTCAGGCCTGCAACGTGCTGTCAAG
GAGGCCCTGTCAGCTGTGCTCCCCCGAGTGGCGGGGCCAGCAGGTCTTCCTCAAGCCGGACGAGCCGCCGCCGCCGCCGCAGCCATGCGC

>In-frame_ENST00000581870_ENST00000544570_TCGA-YL-A8SF-01A_CASKIN2_chr17_73509792_-_PDE2A_chr11_72353370_length(amino acids)=258AA_start in transcript=90_stop in transcript=866
MLSGWALVFHSQAGKIGVPSPSPSWSCRKPQADIHPDFHVAFTPSKISFPSCGGSSRSTFGSIPQYLTRSPLPGTPDLLPRNREPSKGLW
HGALTPQLGPVACLCPGLLSVELSPGASMGREQDLILAVKNGDVTGVQKLVAKVKATKTSCCRTCSPKRQSCTSAWPPTVSTGPRCPTSS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CASKIN2-PDE2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CASKIN2-PDE2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CASKIN2-PDE2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePDE2AC0006142Malignant neoplasm of breast1CTD_human
TgenePDE2AC0678222Breast Carcinoma1CTD_human
TgenePDE2AC1257931Mammary Neoplasms, Human1CTD_human
TgenePDE2AC1458155Mammary Neoplasms1CTD_human
TgenePDE2AC4704874Mammary Carcinoma, Human1CTD_human