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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CASP10-CGA (FusionGDB2 ID:13257) |
Fusion Gene Summary for CASP10-CGA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CASP10-CGA | Fusion gene ID: 13257 | Hgene | Tgene | Gene symbol | CASP10 | CGA | Gene ID | 843 | 1113 |
| Gene name | caspase 10 | chromogranin A | |
| Synonyms | ALPS2|FLICE2|MCH4 | CGA | |
| Cytomap | 2q33.1 | 14q32.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | caspase-10CASP-10FADD-like ICE2FAS-associated death domain protein interleukin-1B-converting enzyme 2ICE-like apoptotic protease 4apoptotic protease MCH-4caspase 10 apoptosis-related cysteine peptidasecaspase 10, apoptosis-related cysteine protease | chromogranin-ASP-Ibetagranin (N-terminal fragment of chromogranin A)catestatinchromofunginparathyroid secretory protein 1pituitary secretory protein I | |
| Modification date | 20200313 | 20200315 | |
| UniProtAcc | Q92851 | Q8N884 | |
| Ensembl transtripts involved in fusion gene | ENST00000286186, ENST00000360132, ENST00000272879, ENST00000374650, ENST00000346817, ENST00000313728, ENST00000448480, ENST00000492363, | ENST00000369582, | |
| Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 8 X 7 X 4=224 |
| # samples | 6 | 8 | |
| ** MAII score | log2(6/60*10)=0 | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CASP10 [Title/Abstract] AND CGA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CASP10(202061223)-CGA(87796110), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CGA | GO:0002551 | mast cell chemotaxis | 21214543 |
| Tgene | CGA | GO:0032762 | mast cell cytokine production | 21214543 |
| Tgene | CGA | GO:0033604 | negative regulation of catecholamine secretion | 15326220 |
| Tgene | CGA | GO:0043303 | mast cell degranulation | 21214543 |
| Tgene | CGA | GO:0045576 | mast cell activation | 21214543 |
| Tgene | CGA | GO:0050829 | defense response to Gram-negative bacterium | 15723172 |
| Tgene | CGA | GO:0050830 | defense response to Gram-positive bacterium | 15723172 |
| Fusion gene breakpoints across CASP10 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across CGA (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BE842422 | CASP10 | chr2 | 202061223 | + | CGA | chr6 | 87796110 | + |
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Fusion Gene ORF analysis for CASP10-CGA |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000286186 | ENST00000369582 | CASP10 | chr2 | 202061223 | + | CGA | chr6 | 87796110 | + |
| intron-3CDS | ENST00000360132 | ENST00000369582 | CASP10 | chr2 | 202061223 | + | CGA | chr6 | 87796110 | + |
| intron-3CDS | ENST00000272879 | ENST00000369582 | CASP10 | chr2 | 202061223 | + | CGA | chr6 | 87796110 | + |
| intron-3CDS | ENST00000374650 | ENST00000369582 | CASP10 | chr2 | 202061223 | + | CGA | chr6 | 87796110 | + |
| intron-3CDS | ENST00000346817 | ENST00000369582 | CASP10 | chr2 | 202061223 | + | CGA | chr6 | 87796110 | + |
| intron-3CDS | ENST00000313728 | ENST00000369582 | CASP10 | chr2 | 202061223 | + | CGA | chr6 | 87796110 | + |
| intron-3CDS | ENST00000448480 | ENST00000369582 | CASP10 | chr2 | 202061223 | + | CGA | chr6 | 87796110 | + |
| intron-3CDS | ENST00000492363 | ENST00000369582 | CASP10 | chr2 | 202061223 | + | CGA | chr6 | 87796110 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CASP10-CGA |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CASP10-CGA |
| Go to FGviewer for the breakpoints of :-: - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CASP10 | CGA |
| FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. {ECO:0000269|PubMed:11717445}.; FUNCTION: Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. {ECO:0000269|PubMed:17822854}.; FUNCTION: Isoform C is proteolytically inactive. {ECO:0000269|PubMed:11717445}. | FUNCTION: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity (PubMed:23258413, PubMed:23707061, PubMed:23722159, PubMed:24077100, PubMed:25131990, PubMed:29976794, PubMed:30799039). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28363908, PubMed:28214358). Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production (PubMed:28363908, PubMed:28314590). Preferentially recognizes and binds curved long DNAs (PubMed:30007416). In contrast to other mammals, human CGAS displays species-specific mechanisms of DNA recognition and produces less cyclic GMP-AMP (cGAMP), allowing a more fine-tuned response to pathogens (PubMed:30007416). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-1, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1, which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria, such as M.tuberculosis (PubMed:26048138). cGAMP can be transferred from producing cells to neighboring cells through gap junctions, leading to promote TMEM173/STING activation and convey immune response to connecting cells (PubMed:24077100). cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). In addition to antiviral activity, also involved in the response to cellular stresses, such as senescence, DNA damage or genome instability (PubMed:28738408, PubMed:28759889). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells, leading to trigger type-I interferon production via TMEM173/STING and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408, PubMed:28759889). Micronuclei, which as frequently found in cancer cells, consist of chromatin surrounded by its own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, CGAS binds self-DNA exposed to the cytosol, leading to cGAMP synthesis and subsequent activation of TMEM173/STING and type-I interferon production (PubMed:28738408, PubMed:28759889). Acts as a suppressor of DNA repair in response to DNA damage: translocates to the nucleus following dephosphorylation at Tyr-215 and inhibits homologous recombination repair by interacting with PARP1, the CGAS-PARP1 interaction leading to impede the formation of the PARP1-TIMELESS complex (PubMed:30356214). {ECO:0000250|UniProtKB:Q8C6L5, ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:23258413, ECO:0000269|PubMed:23707061, ECO:0000269|PubMed:23707065, ECO:0000269|PubMed:23722159, ECO:0000269|PubMed:23929945, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:24116191, ECO:0000269|PubMed:24462292, ECO:0000269|PubMed:25131990, ECO:0000269|PubMed:26046437, ECO:0000269|PubMed:26048138, ECO:0000269|PubMed:26229115, ECO:0000269|PubMed:26300263, ECO:0000269|PubMed:28214358, ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:28363908, ECO:0000269|PubMed:28738408, ECO:0000269|PubMed:28759889, ECO:0000269|PubMed:29976794, ECO:0000269|PubMed:30007416, ECO:0000269|PubMed:30356214, ECO:0000269|PubMed:30799039}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CASP10-CGA |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for CASP10-CGA |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CASP10-CGA |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CASP10-CGA |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CASP10 | C1328840 | Autoimmune Lymphoproliferative Syndrome | 2 | ORPHANET |
| Hgene | CASP10 | C1858968 | Autoimmune Lymphoproliferative Syndrome, Type IIA | 2 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
| Hgene | CASP10 | C0007114 | Malignant neoplasm of skin | 1 | CTD_human |
| Hgene | CASP10 | C0025202 | melanoma | 1 | CTD_human |
| Hgene | CASP10 | C0037286 | Skin Neoplasms | 1 | CTD_human |
| Hgene | CASP10 | C0699791 | Stomach Carcinoma | 1 | CGI;UNIPROT |
| Hgene | CASP10 | C4721532 | Lymphoma, Non-Hodgkin, Familial | 1 | CTD_human;UNIPROT |
| Tgene | CGA | C0001621 | Adrenal Gland Diseases | 1 | CTD_human |
| Tgene | CGA | C0004238 | Atrial Fibrillation | 1 | CTD_human |
| Tgene | CGA | C0018991 | Hemiplegia | 1 | CTD_human |
| Tgene | CGA | C0028960 | Oligospermia | 1 | CTD_human |
| Tgene | CGA | C0029928 | Ovarian Diseases | 1 | CTD_human |
| Tgene | CGA | C0042131 | Uterine Diseases | 1 | CTD_human |
| Tgene | CGA | C0085622 | Monoplegia | 1 | CTD_human |
| Tgene | CGA | C0154693 | Hemiplegia, Flaccid | 1 | CTD_human |
| Tgene | CGA | C0154694 | Hemiplegia, Spastic | 1 | CTD_human |
| Tgene | CGA | C0235480 | Paroxysmal atrial fibrillation | 1 | CTD_human |
| Tgene | CGA | C0235874 | Disease Exacerbation | 1 | CTD_human |
| Tgene | CGA | C0278110 | Hemiplegia, Crossed | 1 | CTD_human |
| Tgene | CGA | C0392550 | Hemiplegia, Infantile | 1 | CTD_human |
| Tgene | CGA | C0521662 | Hemiplegia, Transient | 1 | CTD_human |
| Tgene | CGA | C0751195 | Hemiplegia, Post-Ictal | 1 | CTD_human |
| Tgene | CGA | C1720816 | Endometrial Diseases | 1 | CTD_human |
| Tgene | CGA | C2585653 | Persistent atrial fibrillation | 1 | CTD_human |
| Tgene | CGA | C2931367 | Thyroid cancer, follicular | 1 | CTD_human |
| Tgene | CGA | C3468561 | familial atrial fibrillation | 1 | CTD_human |
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