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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CATSPERG-RASSF1 (FusionGDB2 ID:13361)

Fusion Gene Summary for CATSPERG-RASSF1

check button Fusion gene summary
Fusion gene informationFusion gene name: CATSPERG-RASSF1
Fusion gene ID: 13361
HgeneTgene
Gene symbol

CATSPERG

RASSF1

Gene ID

57828

11186

Gene namecation channel sperm associated auxiliary subunit gammaRas association domain family member 1
SynonymsC19orf15123F2|NORE2A|RASSF1A|RDA32|REH3P21
Cytomap

19q13.2

3p21.31

Type of geneprotein-codingprotein-coding
Descriptioncation channel sperm-associated protein subunit gammacatsper channel auxiliary subunit gammaras association domain-containing protein 1Ras association (RalGDS/AF-6) domain family member 1WUGSC:H_LUCA12.5cardiac-specific ras association domain family 1 proteinpancreas-specific ras association domain family 1 proteintumor suppressor protein R
Modification date2020031320200322
UniProtAcc

Q6ZRH7

.
Ensembl transtripts involved in fusion geneENST00000409235, ENST00000410018, 
ENST00000215069, ENST00000467739, 
ENST00000327761, ENST00000395126, 
ENST00000357043, ENST00000359365, 
ENST00000488024, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 1 X 2=4
# samples 42
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/4*10)=2.32192809488736
Context

PubMed: CATSPERG [Title/Abstract] AND RASSF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCATSPERG(38828144)-RASSF1(50369585), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRASSF1

GO:0007265

Ras protein signal transduction

15109305


check buttonFusion gene breakpoints across CATSPERG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RASSF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-SH-A7BD-01ACATSPERGchr19

38828144

+RASSF1chr3

50369585

-
ChimerDB4MESOTCGA-SH-A7BDCATSPERGchr19

38828144

+RASSF1chr3

50369585

-
ChimerDB4MESOTCGA-SH-A7BD-01ACATSPERGchr19

38828144

+RASSF1chr3

50369585

-
ChimerDB4MESOTCGA-SH-A7BD-01ACATSPERGchr19

38828144

-RASSF1chr3

50369585

-


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Fusion Gene ORF analysis for CATSPERG-RASSF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000409235ENST00000327761CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
5CDS-5UTRENST00000409235ENST00000395126CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
5CDS-5UTRENST00000409235ENST00000357043CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
5CDS-5UTRENST00000409235ENST00000359365CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
5CDS-intronENST00000409235ENST00000488024CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
In-frameENST00000410018ENST00000327761CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
5CDS-5UTRENST00000410018ENST00000395126CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
5CDS-5UTRENST00000410018ENST00000357043CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
5CDS-5UTRENST00000410018ENST00000359365CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
5CDS-intronENST00000410018ENST00000488024CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
In-frameENST00000215069ENST00000327761CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
5CDS-5UTRENST00000215069ENST00000395126CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
5CDS-5UTRENST00000215069ENST00000357043CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
5CDS-5UTRENST00000215069ENST00000359365CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
5CDS-intronENST00000215069ENST00000488024CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
intron-3CDSENST00000467739ENST00000327761CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
intron-5UTRENST00000467739ENST00000395126CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
intron-5UTRENST00000467739ENST00000357043CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
intron-5UTRENST00000467739ENST00000359365CATSPERGchr19

38828144

+RASSF1chr3

50369585

-
intron-intronENST00000467739ENST00000488024CATSPERGchr19

38828144

+RASSF1chr3

50369585

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409235CATSPERGchr1938828144+ENST00000327761RASSF1chr350369585-1844385761050324
ENST00000410018CATSPERGchr1938828144+ENST00000327761RASSF1chr350369585-1844385761050324
ENST00000215069CATSPERGchr1938828144+ENST00000327761RASSF1chr350369585-17773180983327

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409235ENST00000327761CATSPERGchr1938828144+RASSF1chr350369585-0.0072814360.9927186
ENST00000410018ENST00000327761CATSPERGchr1938828144+RASSF1chr350369585-0.0072814360.9927186
ENST00000215069ENST00000327761CATSPERGchr1938828144+RASSF1chr350369585-0.0058115870.9941884

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Fusion Genomic Features for CATSPERG-RASSF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CATSPERG-RASSF1


check button Go to

FGviewer for the breakpoints of chr19:38828144-chr3:50369585

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CATSPERG

Q6ZRH7

.
FUNCTION: Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. {ECO:0000250|UniProtKB:C6KI89}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRASSF1chr19:38828144chr3:50369585ENST0000032776105198_29249.0271.0DomainRas-associating
TgeneRASSF1chr19:38828144chr3:50369585ENST0000032776105294_34149.0271.0DomainSARAH
TgeneRASSF1chr19:38828144chr3:50369585ENST0000035704316198_292123.0345.0DomainRas-associating
TgeneRASSF1chr19:38828144chr3:50369585ENST0000035704316294_341123.0345.0DomainSARAH
TgeneRASSF1chr19:38828144chr3:50369585ENST0000035936516198_292119.0341.0DomainRas-associating
TgeneRASSF1chr19:38828144chr3:50369585ENST0000035936516294_341119.0341.0DomainSARAH
TgeneRASSF1chr19:38828144chr3:50369585ENST0000039512616198_2920190.0DomainRas-associating
TgeneRASSF1chr19:38828144chr3:50369585ENST0000039512616294_3410190.0DomainSARAH
TgeneRASSF1chr19:38828144chr3:50369585ENST0000032776105315_31849.0271.0RegionNote=MOAP1-binding
TgeneRASSF1chr19:38828144chr3:50369585ENST0000035704316315_318123.0345.0RegionNote=MOAP1-binding
TgeneRASSF1chr19:38828144chr3:50369585ENST0000035936516315_318119.0341.0RegionNote=MOAP1-binding
TgeneRASSF1chr19:38828144chr3:50369585ENST0000039512616315_3180190.0RegionNote=MOAP1-binding
TgeneRASSF1chr19:38828144chr3:50369585ENST000003277610551_10549.0271.0Zinc fingerPhorbol-ester/DAG-type
TgeneRASSF1chr19:38828144chr3:50369585ENST000003951261651_1050190.0Zinc fingerPhorbol-ester/DAG-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCATSPERGchr19:38828144chr3:50369585ENST00000409235+2291088_115990.01160.0Topological domainCytoplasmic
HgeneCATSPERGchr19:38828144chr3:50369585ENST00000409235+22936_106690.01160.0Topological domainExtracellular
HgeneCATSPERGchr19:38828144chr3:50369585ENST00000409235+2291067_108790.01160.0TransmembraneHelical
TgeneRASSF1chr19:38828144chr3:50369585ENST000003570431651_105123.0345.0Zinc fingerPhorbol-ester/DAG-type
TgeneRASSF1chr19:38828144chr3:50369585ENST000003593651651_105119.0341.0Zinc fingerPhorbol-ester/DAG-type


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Fusion Gene Sequence for CATSPERG-RASSF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000409235_ENST00000327761_TCGA-SH-A7BD-01A_CATSPERG_chr19_38828144_+_RASSF1_chr3_50369585_length(transcript)=1844nt_BP=385nt
GAAGTCGGCTGTGGAAGTGTGGGCGGCCATTTTGAGACCGGGCAAGAGGGGCGGGACTGGTGCGGCCGAGTGACAGTTGACCGGTTTTAA
CCAAGTGACTGGTTCTAGCCACGTTATGTGCGGCCCAGCCATGTTCCCTGCCGGTCCTCCGTGGCCCAGAGTCCGAGTCGTGCAGGTGCT
GTGGGCCCTGCTGGCAGTGCTCCTGGCGTCGTGGAGGCTGTGGGCGATCAAGGATTTCCAGGAATGCACCTGGCAGGTTGTCCTGAACGA
GTTTAAGAGGGTAGGCGAGAGTGGTGTGAGCGACAGCTTCTTTGAGCAAGAGCCCGTGGACACAGTGAGCAGCTTGTTTCACATGCTGGT
GGACTCACCCATCGACCCGAGCGAGGACGAGCCTGTGGAGTGGGAGACACCTGACCTTTCTCAAGCTGAGATTGAGCAGAAGATCAAGGA
GTACAATGCCCAGATCAACAGCAACCTCTTCATGAGCTTGAACAAGGACGGTTCTTACACAGGCTTCATCAAGGTTCAGCTGAAGCTGGT
GCGCCCTGTCTCTGTGCCCTCCAGCAAGAAGCCACCCTCCTTGCAGGATGCCCGGCGGGGCCCAGGACGGGGCACAAGTGTCAGGCGCCG
CACTTCCTTTTACCTGCCCAAGGATGCTGTCAAGCACCTGCATGTGCTGTCACGCACAAGGGCACGTGAAGTCATTGAGGCCCTGCTGCG
AAAGTTCTTGGTGGTGGATGACCCCCGCAAGTTTGCACTCTTTGAGCGCGCTGAGCGTCACGGCCAAGTGTACTTGCGGAAGCTGTTGGA
TGATGAGCAGCCCCTGCGGCTGCGGCTCCTGGCAGGGCCCAGTGACAAGGCCCTGAGCTTTGTCCTGAAGGAAAATGACTCTGGGGAGGT
GAACTGGGACGCCTTCAGCATGCCTGAACTACATAACTTCCTACGTATCCTGCAGCGGGAGGAGGAGGAGCACCTCCGCCAGATCCTGCA
GAAGTACTCCTATTGCCGCCAGAAGATCCAAGAGGCCCTGCACGCCTGCCCCCTTGGGTGACCTCTTGTACCCCCAGGTGGAAGGCAGAC
AGCAGGCAGCGCCAAGTGCGTGCCGTGTGAGTGTGACAGGGCCAGTGGGGCCTGTGGAATGAGTGTGCATGGAGGCCCTCCTGTGCTGGG
GGAATGAGCCCAGAGAACAGCGAAGTAGCTTGCTCCCTGTGTCCACCTGTGGGTGTAGCCAGGTATGGCTCTGCACCCCTCTGCCCTCAT
TACTGGGCCTTAGTGGGCCAGGGCTGCCCTGAGAAGCTGCTCCAGGCCTGCAGCAGGAGTGGTGCAGACAGAAGTCTCCTCAATTTTTGT
CTCAGAAGTGAAAATCTTGGAGACCCTGCAAACAGAACAGGGTCATGTTTGCAGGGGTGACGGCCCTCATCTATGAGGAAAGGTTTTGGA
TCTTGAATGTGGTCTCAGGATATCCTTATCAGAGCTAAGGGTGGGTGCTCAGAATAAGGCAGGCATTGAGGAAGAGTCTTGGTTTCTCTC
TACAGTGCCAACTCCTCACACACCCTGAGGTCAGGGAGTGCTGGCTCACAGTACAGCATGTGCCTTAATGCTTCATATGAGGAGGATGTC
CCTGGGCCAGGGTCTGTGTGAATGTGGGCACTGGCCCAGGTTCATACCTTATTTGCTAATCAAAGCCAGGGTCTCTCCCTCAGGTGTTTT
TTATGAAGTGCGTGAATGTATGTAATGTGTGGTGGCCTCAGCTGAATGCCTCCTGTGGGGAAAGGGGTTGGGGTGACAGTCATCATCAGG

>In-frame_ENST00000409235_ENST00000327761_TCGA-SH-A7BD-01A_CATSPERG_chr19_38828144_+_RASSF1_chr3_50369585_length(amino acids)=324AA_start in transcript=76_stop in transcript=1050
MTGFNQVTGSSHVMCGPAMFPAGPPWPRVRVVQVLWALLAVLLASWRLWAIKDFQECTWQVVLNEFKRVGESGVSDSFFEQEPVDTVSSL
FHMLVDSPIDPSEDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGT
SVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKEN

--------------------------------------------------------------
>In-frame_ENST00000410018_ENST00000327761_TCGA-SH-A7BD-01A_CATSPERG_chr19_38828144_+_RASSF1_chr3_50369585_length(transcript)=1844nt_BP=385nt
GAAGTCGGCTGTGGAAGTGTGGGCGGCCATTTTGAGACCGGGCAAGAGGGGCGGGACTGGTGCGGCCGAGTGACAGTTGACCGGTTTTAA
CCAAGTGACTGGTTCTAGCCACGTTATGTGCGGCCCAGCCATGTTCCCTGCCGGTCCTCCGTGGCCCAGAGTCCGAGTCGTGCAGGTGCT
GTGGGCCCTGCTGGCAGTGCTCCTGGCGTCGTGGAGGCTGTGGGCGATCAAGGATTTCCAGGAATGCACCTGGCAGGTTGTCCTGAACGA
GTTTAAGAGGGTAGGCGAGAGTGGTGTGAGCGACAGCTTCTTTGAGCAAGAGCCCGTGGACACAGTGAGCAGCTTGTTTCACATGCTGGT
GGACTCACCCATCGACCCGAGCGAGGACGAGCCTGTGGAGTGGGAGACACCTGACCTTTCTCAAGCTGAGATTGAGCAGAAGATCAAGGA
GTACAATGCCCAGATCAACAGCAACCTCTTCATGAGCTTGAACAAGGACGGTTCTTACACAGGCTTCATCAAGGTTCAGCTGAAGCTGGT
GCGCCCTGTCTCTGTGCCCTCCAGCAAGAAGCCACCCTCCTTGCAGGATGCCCGGCGGGGCCCAGGACGGGGCACAAGTGTCAGGCGCCG
CACTTCCTTTTACCTGCCCAAGGATGCTGTCAAGCACCTGCATGTGCTGTCACGCACAAGGGCACGTGAAGTCATTGAGGCCCTGCTGCG
AAAGTTCTTGGTGGTGGATGACCCCCGCAAGTTTGCACTCTTTGAGCGCGCTGAGCGTCACGGCCAAGTGTACTTGCGGAAGCTGTTGGA
TGATGAGCAGCCCCTGCGGCTGCGGCTCCTGGCAGGGCCCAGTGACAAGGCCCTGAGCTTTGTCCTGAAGGAAAATGACTCTGGGGAGGT
GAACTGGGACGCCTTCAGCATGCCTGAACTACATAACTTCCTACGTATCCTGCAGCGGGAGGAGGAGGAGCACCTCCGCCAGATCCTGCA
GAAGTACTCCTATTGCCGCCAGAAGATCCAAGAGGCCCTGCACGCCTGCCCCCTTGGGTGACCTCTTGTACCCCCAGGTGGAAGGCAGAC
AGCAGGCAGCGCCAAGTGCGTGCCGTGTGAGTGTGACAGGGCCAGTGGGGCCTGTGGAATGAGTGTGCATGGAGGCCCTCCTGTGCTGGG
GGAATGAGCCCAGAGAACAGCGAAGTAGCTTGCTCCCTGTGTCCACCTGTGGGTGTAGCCAGGTATGGCTCTGCACCCCTCTGCCCTCAT
TACTGGGCCTTAGTGGGCCAGGGCTGCCCTGAGAAGCTGCTCCAGGCCTGCAGCAGGAGTGGTGCAGACAGAAGTCTCCTCAATTTTTGT
CTCAGAAGTGAAAATCTTGGAGACCCTGCAAACAGAACAGGGTCATGTTTGCAGGGGTGACGGCCCTCATCTATGAGGAAAGGTTTTGGA
TCTTGAATGTGGTCTCAGGATATCCTTATCAGAGCTAAGGGTGGGTGCTCAGAATAAGGCAGGCATTGAGGAAGAGTCTTGGTTTCTCTC
TACAGTGCCAACTCCTCACACACCCTGAGGTCAGGGAGTGCTGGCTCACAGTACAGCATGTGCCTTAATGCTTCATATGAGGAGGATGTC
CCTGGGCCAGGGTCTGTGTGAATGTGGGCACTGGCCCAGGTTCATACCTTATTTGCTAATCAAAGCCAGGGTCTCTCCCTCAGGTGTTTT
TTATGAAGTGCGTGAATGTATGTAATGTGTGGTGGCCTCAGCTGAATGCCTCCTGTGGGGAAAGGGGTTGGGGTGACAGTCATCATCAGG

>In-frame_ENST00000410018_ENST00000327761_TCGA-SH-A7BD-01A_CATSPERG_chr19_38828144_+_RASSF1_chr3_50369585_length(amino acids)=324AA_start in transcript=76_stop in transcript=1050
MTGFNQVTGSSHVMCGPAMFPAGPPWPRVRVVQVLWALLAVLLASWRLWAIKDFQECTWQVVLNEFKRVGESGVSDSFFEQEPVDTVSSL
FHMLVDSPIDPSEDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGT
SVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKEN

--------------------------------------------------------------
>In-frame_ENST00000215069_ENST00000327761_TCGA-SH-A7BD-01A_CATSPERG_chr19_38828144_+_RASSF1_chr3_50369585_length(transcript)=1777nt_BP=318nt
ATGGGAAGGAAGAGTAAGAAGTGGGGCAAGAAGGTGTCGCGGTACGAGGGGAAGGTGAGACTCAAGAAGGTGCCGGCTAAGAAGCTGGTG
CCGGCGTGGAAGGAGAAGGTGCTGTGGGCCCTGCTGGCAGTGCTCCTGGCGTCGTGGAGGCTGTGGGCGATCAAGGATTTCCAGGAATGC
ACCTGGCAGGTTGTCCTGAACGAGTTTAAGAGGGTAGGCGAGAGTGGTGTGAGCGACAGCTTCTTTGAGCAAGAGCCCGTGGACACAGTG
AGCAGCTTGTTTCACATGCTGGTGGACTCACCCATCGACCCGAGCGAGGACGAGCCTGTGGAGTGGGAGACACCTGACCTTTCTCAAGCT
GAGATTGAGCAGAAGATCAAGGAGTACAATGCCCAGATCAACAGCAACCTCTTCATGAGCTTGAACAAGGACGGTTCTTACACAGGCTTC
ATCAAGGTTCAGCTGAAGCTGGTGCGCCCTGTCTCTGTGCCCTCCAGCAAGAAGCCACCCTCCTTGCAGGATGCCCGGCGGGGCCCAGGA
CGGGGCACAAGTGTCAGGCGCCGCACTTCCTTTTACCTGCCCAAGGATGCTGTCAAGCACCTGCATGTGCTGTCACGCACAAGGGCACGT
GAAGTCATTGAGGCCCTGCTGCGAAAGTTCTTGGTGGTGGATGACCCCCGCAAGTTTGCACTCTTTGAGCGCGCTGAGCGTCACGGCCAA
GTGTACTTGCGGAAGCTGTTGGATGATGAGCAGCCCCTGCGGCTGCGGCTCCTGGCAGGGCCCAGTGACAAGGCCCTGAGCTTTGTCCTG
AAGGAAAATGACTCTGGGGAGGTGAACTGGGACGCCTTCAGCATGCCTGAACTACATAACTTCCTACGTATCCTGCAGCGGGAGGAGGAG
GAGCACCTCCGCCAGATCCTGCAGAAGTACTCCTATTGCCGCCAGAAGATCCAAGAGGCCCTGCACGCCTGCCCCCTTGGGTGACCTCTT
GTACCCCCAGGTGGAAGGCAGACAGCAGGCAGCGCCAAGTGCGTGCCGTGTGAGTGTGACAGGGCCAGTGGGGCCTGTGGAATGAGTGTG
CATGGAGGCCCTCCTGTGCTGGGGGAATGAGCCCAGAGAACAGCGAAGTAGCTTGCTCCCTGTGTCCACCTGTGGGTGTAGCCAGGTATG
GCTCTGCACCCCTCTGCCCTCATTACTGGGCCTTAGTGGGCCAGGGCTGCCCTGAGAAGCTGCTCCAGGCCTGCAGCAGGAGTGGTGCAG
ACAGAAGTCTCCTCAATTTTTGTCTCAGAAGTGAAAATCTTGGAGACCCTGCAAACAGAACAGGGTCATGTTTGCAGGGGTGACGGCCCT
CATCTATGAGGAAAGGTTTTGGATCTTGAATGTGGTCTCAGGATATCCTTATCAGAGCTAAGGGTGGGTGCTCAGAATAAGGCAGGCATT
GAGGAAGAGTCTTGGTTTCTCTCTACAGTGCCAACTCCTCACACACCCTGAGGTCAGGGAGTGCTGGCTCACAGTACAGCATGTGCCTTA
ATGCTTCATATGAGGAGGATGTCCCTGGGCCAGGGTCTGTGTGAATGTGGGCACTGGCCCAGGTTCATACCTTATTTGCTAATCAAAGCC
AGGGTCTCTCCCTCAGGTGTTTTTTATGAAGTGCGTGAATGTATGTAATGTGTGGTGGCCTCAGCTGAATGCCTCCTGTGGGGAAAGGGG

>In-frame_ENST00000215069_ENST00000327761_TCGA-SH-A7BD-01A_CATSPERG_chr19_38828144_+_RASSF1_chr3_50369585_length(amino acids)=327AA_start in transcript=0_stop in transcript=983
MGRKSKKWGKKVSRYEGKVRLKKVPAKKLVPAWKEKVLWALLAVLLASWRLWAIKDFQECTWQVVLNEFKRVGESGVSDSFFEQEPVDTV
SSLFHMLVDSPIDPSEDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPG
RGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CATSPERG-RASSF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CATSPERG-RASSF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CATSPERG-RASSF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRASSF1C0025500Mesothelioma2CTD_human
TgeneRASSF1C0001418Adenocarcinoma1CTD_human
TgeneRASSF1C0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneRASSF1C0005686Urinary Bladder Diseases1CTD_human
TgeneRASSF1C0005695Bladder Neoplasm1CTD_human
TgeneRASSF1C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneRASSF1C0007194Hypertrophic Cardiomyopathy1CTD_human
TgeneRASSF1C0021390Inflammatory Bowel Diseases1CTD_human
TgeneRASSF1C0024121Lung Neoplasms1CTD_human
TgeneRASSF1C0024667Animal Mammary Neoplasms1CTD_human
TgeneRASSF1C0025149Medulloblastoma1CTD_human
TgeneRASSF1C0036323Schistosomiasis1CTD_human
TgeneRASSF1C0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneRASSF1C0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneRASSF1C0205643Carcinoma, Cribriform1CTD_human
TgeneRASSF1C0205644Carcinoma, Granular Cell1CTD_human
TgeneRASSF1C0205645Adenocarcinoma, Tubular1CTD_human
TgeneRASSF1C0205833Medullomyoblastoma1CTD_human
TgeneRASSF1C0242379Malignant neoplasm of lung1CTD_human
TgeneRASSF1C0278510Childhood Medulloblastoma1CTD_human
TgeneRASSF1C0278876Adult Medulloblastoma1CTD_human
TgeneRASSF1C0751291Desmoplastic Medulloblastoma1CTD_human
TgeneRASSF1C1257925Mammary Carcinoma, Animal1CTD_human
TgeneRASSF1C1275668Melanotic medulloblastoma1CTD_human
TgeneRASSF1C1449861Micronuclei, Chromosome-Defective1CTD_human
TgeneRASSF1C1449862Micronuclei, Genotoxicant-Induced1CTD_human
TgeneRASSF1C4551472Hypertrophic obstructive cardiomyopathy1CTD_human