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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCDC14-SDCCAG8 (FusionGDB2 ID:13687)

Fusion Gene Summary for CCDC14-SDCCAG8

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC14-SDCCAG8
Fusion gene ID: 13687
HgeneTgene
Gene symbol

CCDC14

SDCCAG8

Gene ID

64770

10806

Gene namecoiled-coil domain containing 14SHH signaling and ciliogenesis regulator SDCCAG8
Synonyms-BBS16|CCCAP|CCCAP SLSN7|HSPC085|NPHP10|NY-CO-8|SLSN7|hCCCAP
Cytomap

3q21.1

1q43-q44

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 14serologically defined colon cancer antigen 8Bardet-Biedl syndrome 16antigen NY-CO-8centrosomal colon cancer autoantigen proteinnephrocystin 10
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000310351, ENST00000488653, 
ENST00000485727, ENST00000489746, 
ENST00000433542, ENST00000483247, 
ENST00000355875, ENST00000366541, 
ENST00000343783, ENST00000391846, 
ENST00000496361, 
Fusion gene scores* DoF score10 X 6 X 6=36022 X 19 X 10=4180
# samples 1026
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/4180*10)=-4.00691941393979
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCDC14 [Title/Abstract] AND SDCCAG8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCDC14(123679990)-SDCCAG8(243468013), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CCDC14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SDCCAG8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAA328928CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+


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Fusion Gene ORF analysis for CCDC14-SDCCAG8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000310351ENST00000355875CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3CDSENST00000310351ENST00000366541CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3CDSENST00000310351ENST00000343783CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3CDSENST00000310351ENST00000391846CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3UTRENST00000310351ENST00000496361CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
In-frameENST00000488653ENST00000355875CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
In-frameENST00000488653ENST00000366541CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
In-frameENST00000488653ENST00000343783CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
In-frameENST00000488653ENST00000391846CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
5CDS-3UTRENST00000488653ENST00000496361CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3CDSENST00000485727ENST00000355875CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3CDSENST00000485727ENST00000366541CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3CDSENST00000485727ENST00000343783CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3CDSENST00000485727ENST00000391846CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3UTRENST00000485727ENST00000496361CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3CDSENST00000489746ENST00000355875CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3CDSENST00000489746ENST00000366541CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3CDSENST00000489746ENST00000343783CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3CDSENST00000489746ENST00000391846CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
intron-3UTRENST00000489746ENST00000496361CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
In-frameENST00000433542ENST00000355875CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
In-frameENST00000433542ENST00000366541CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
In-frameENST00000433542ENST00000343783CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
In-frameENST00000433542ENST00000391846CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
5CDS-3UTRENST00000433542ENST00000496361CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
5UTR-3CDSENST00000483247ENST00000355875CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
5UTR-3CDSENST00000483247ENST00000366541CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
5UTR-3CDSENST00000483247ENST00000343783CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
5UTR-3CDSENST00000483247ENST00000391846CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+
5UTR-3UTRENST00000483247ENST00000496361CCDC14chr3

123679990

-SDCCAG8chr1

243468013

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000488653CCDC14chr3123679990-ENST00000355875SDCCAG8chr1243468013+2033265281731567
ENST00000488653CCDC14chr3123679990-ENST00000366541SDCCAG8chr1243468013+2039265281731567
ENST00000488653CCDC14chr3123679990-ENST00000343783SDCCAG8chr1243468013+2037265281731567
ENST00000488653CCDC14chr3123679990-ENST00000391846SDCCAG8chr1243468013+67326528672215
ENST00000433542CCDC14chr3123679990-ENST00000355875SDCCAG8chr1243468013+23425742502040596
ENST00000433542CCDC14chr3123679990-ENST00000366541SDCCAG8chr1243468013+23485742502040596
ENST00000433542CCDC14chr3123679990-ENST00000343783SDCCAG8chr1243468013+23465742502040596
ENST00000433542CCDC14chr3123679990-ENST00000391846SDCCAG8chr1243468013+982574250981244

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000488653ENST00000355875CCDC14chr3123679990-SDCCAG8chr1243468013+0.003911950.996088
ENST00000488653ENST00000366541CCDC14chr3123679990-SDCCAG8chr1243468013+0.0037708680.9962291
ENST00000488653ENST00000343783CCDC14chr3123679990-SDCCAG8chr1243468013+0.0037018130.99629825
ENST00000488653ENST00000391846CCDC14chr3123679990-SDCCAG8chr1243468013+0.004316270.9956838
ENST00000433542ENST00000355875CCDC14chr3123679990-SDCCAG8chr1243468013+0.0067107280.9932893
ENST00000433542ENST00000366541CCDC14chr3123679990-SDCCAG8chr1243468013+0.0065890950.9934109
ENST00000433542ENST00000343783CCDC14chr3123679990-SDCCAG8chr1243468013+0.006510370.9934896
ENST00000433542ENST00000391846CCDC14chr3123679990-SDCCAG8chr1243468013+0.028985570.9710144

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Fusion Genomic Features for CCDC14-SDCCAG8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CCDC14chr3123679990-SDCCAG8chr1243468014+0.62167150.37832847
CCDC14chr3123679990-SDCCAG8chr1243468014+0.62167150.37832847

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCDC14-SDCCAG8


check button Go to

FGviewer for the breakpoints of chr3:123679990-chr1:243468013

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSDCCAG8chr3:123679990chr1:243468013ENST00000366541518223_273225.0714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr3:123679990chr1:243468013ENST00000366541518348_707225.0714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr3:123679990chr1:243468013ENST00000391846510223_273225.0361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr3:123679990chr1:243468013ENST00000391846510348_707225.0361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr3:123679990chr1:243468013ENST00000366541518534_692225.0714.0Compositional biasNote=Gln-rich
TgeneSDCCAG8chr3:123679990chr1:243468013ENST00000391846510534_692225.0361.0Compositional biasNote=Gln-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC14chr3:123679990chr1:243468013ENST00000310351-19383_4130.0794.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC14chr3:123679990chr1:243468013ENST00000310351-19483_6180.0794.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC14chr3:123679990chr1:243468013ENST00000433542-112383_41358.0913.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC14chr3:123679990chr1:243468013ENST00000433542-112483_61858.0913.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC14chr3:123679990chr1:243468013ENST00000485727-19383_4130754.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC14chr3:123679990chr1:243468013ENST00000485727-19483_6180754.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC14chr3:123679990chr1:243468013ENST00000488653-113383_41358.0954.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC14chr3:123679990chr1:243468013ENST00000488653-113483_61858.0954.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC14chr3:123679990chr1:243468013ENST00000489746-19383_4130754.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC14chr3:123679990chr1:243468013ENST00000489746-19483_6180754.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr3:123679990chr1:243468013ENST00000366541518129_175225.0714.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr3:123679990chr1:243468013ENST00000391846510129_175225.0361.0Coiled coilOntology_term=ECO:0000255
TgeneSDCCAG8chr3:123679990chr1:243468013ENST00000366541518216_713225.0714.0RegionSufficient for homodimerization
TgeneSDCCAG8chr3:123679990chr1:243468013ENST00000391846510216_713225.0361.0RegionSufficient for homodimerization


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Fusion Gene Sequence for CCDC14-SDCCAG8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000488653_ENST00000355875_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(transcript)=2033nt_BP=265nt
GACAAGCCGGGAAGCTTGGAGGGGTCTATTGCGTACGCCCAAGGCGCTGGGCCTGGAGCAGGAGAAAGGGAGTGGAGGCGCGTCGGAGAC
TATGAAGCGCGGCATTCGGCGGGATCCTTTCCGGAAGCGGAAGCTCGGCGGGCGGGCCAAGAAGGTCCGGGAGCCCACGGCGGTTAATTC
TTTTTACCGTGAGGCTTCACTTCCCTCGGTCTGGGCTTCTCTGAGGCGGCGAGAGATGGTCAGGTCTGGAGCTCGACCGGGCCAGGAGAA
GCTAAAACTTACTTATGAGGAAAAGTGTGAAATTGAGGAATCCCAATTGAAGTTTTTGAGGAACGACTTAGCTGAATATCAGAGAACTTG
TGAAGATCTTAAAGAGCAACTAAAGCATAAAGAATTTCTTCTGGCTGCTAATACTTGTAACCGTGTTGGTGGTCTTTGTTTGAAATGTGC
TCAGCATGAAGCTGTTCTTTCCCAAACCCATACTAATGTTCATATGCAGACCATCGAAAGACTGGTTAAAGAAAGAGATGACTTGATGTC
TGCACTAGTTTCCGTAAGGAGCAGCTTGGCAGATACGCAGCAAAGAGAAGCAAGTGCTTATGAACAGGTGAAACAAGTTTTGCAAATATC
TGAGGAAGCCAATTTTGAAAAAACCAAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAA
AGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAA
GATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGA
GGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGA
GAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAG
AATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACT
GCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGC
CCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTT
GTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAAC
CAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGA
ACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCT
GGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAG
CATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAA
TATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCA
CGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAAT

>In-frame_ENST00000488653_ENST00000355875_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(amino acids)=567AA_start in transcript=28_stop in transcript=1731
MRTPKALGLEQEKGSGGASETMKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSVWASLRRREMVRSGARPGQEKLKLTYEEKC
EIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSL
ADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIA
QLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQH
LEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFL
TKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQ

--------------------------------------------------------------
>In-frame_ENST00000488653_ENST00000366541_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(transcript)=2039nt_BP=265nt
GACAAGCCGGGAAGCTTGGAGGGGTCTATTGCGTACGCCCAAGGCGCTGGGCCTGGAGCAGGAGAAAGGGAGTGGAGGCGCGTCGGAGAC
TATGAAGCGCGGCATTCGGCGGGATCCTTTCCGGAAGCGGAAGCTCGGCGGGCGGGCCAAGAAGGTCCGGGAGCCCACGGCGGTTAATTC
TTTTTACCGTGAGGCTTCACTTCCCTCGGTCTGGGCTTCTCTGAGGCGGCGAGAGATGGTCAGGTCTGGAGCTCGACCGGGCCAGGAGAA
GCTAAAACTTACTTATGAGGAAAAGTGTGAAATTGAGGAATCCCAATTGAAGTTTTTGAGGAACGACTTAGCTGAATATCAGAGAACTTG
TGAAGATCTTAAAGAGCAACTAAAGCATAAAGAATTTCTTCTGGCTGCTAATACTTGTAACCGTGTTGGTGGTCTTTGTTTGAAATGTGC
TCAGCATGAAGCTGTTCTTTCCCAAACCCATACTAATGTTCATATGCAGACCATCGAAAGACTGGTTAAAGAAAGAGATGACTTGATGTC
TGCACTAGTTTCCGTAAGGAGCAGCTTGGCAGATACGCAGCAAAGAGAAGCAAGTGCTTATGAACAGGTGAAACAAGTTTTGCAAATATC
TGAGGAAGCCAATTTTGAAAAAACCAAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAA
AGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAA
GATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGA
GGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGA
GAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAG
AATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACT
GCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGC
CCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTT
GTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAAC
CAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGA
ACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCT
GGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAG
CATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAA
TATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCA
CGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAAT

>In-frame_ENST00000488653_ENST00000366541_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(amino acids)=567AA_start in transcript=28_stop in transcript=1731
MRTPKALGLEQEKGSGGASETMKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSVWASLRRREMVRSGARPGQEKLKLTYEEKC
EIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSL
ADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIA
QLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQH
LEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFL
TKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQ

--------------------------------------------------------------
>In-frame_ENST00000488653_ENST00000343783_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(transcript)=2037nt_BP=265nt
GACAAGCCGGGAAGCTTGGAGGGGTCTATTGCGTACGCCCAAGGCGCTGGGCCTGGAGCAGGAGAAAGGGAGTGGAGGCGCGTCGGAGAC
TATGAAGCGCGGCATTCGGCGGGATCCTTTCCGGAAGCGGAAGCTCGGCGGGCGGGCCAAGAAGGTCCGGGAGCCCACGGCGGTTAATTC
TTTTTACCGTGAGGCTTCACTTCCCTCGGTCTGGGCTTCTCTGAGGCGGCGAGAGATGGTCAGGTCTGGAGCTCGACCGGGCCAGGAGAA
GCTAAAACTTACTTATGAGGAAAAGTGTGAAATTGAGGAATCCCAATTGAAGTTTTTGAGGAACGACTTAGCTGAATATCAGAGAACTTG
TGAAGATCTTAAAGAGCAACTAAAGCATAAAGAATTTCTTCTGGCTGCTAATACTTGTAACCGTGTTGGTGGTCTTTGTTTGAAATGTGC
TCAGCATGAAGCTGTTCTTTCCCAAACCCATACTAATGTTCATATGCAGACCATCGAAAGACTGGTTAAAGAAAGAGATGACTTGATGTC
TGCACTAGTTTCCGTAAGGAGCAGCTTGGCAGATACGCAGCAAAGAGAAGCAAGTGCTTATGAACAGGTGAAACAAGTTTTGCAAATATC
TGAGGAAGCCAATTTTGAAAAAACCAAGGCTTTAATCCAGTGTGACCAGTTGAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAA
AGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAAAAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAA
GATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAAGGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGA
GGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTGTGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGA
GAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAGGGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAG
AATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGCAGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACT
GCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAGCATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGC
CCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAATGGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTT
GTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTGTACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAAC
CAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAAATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGA
ACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAGGCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCT
GGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCTGTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAG
CATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGATTTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAA
TATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCAGTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCA
CGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGTGTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAAT

>In-frame_ENST00000488653_ENST00000343783_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(amino acids)=567AA_start in transcript=28_stop in transcript=1731
MRTPKALGLEQEKGSGGASETMKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSVWASLRRREMVRSGARPGQEKLKLTYEEKC
EIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSL
ADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRAIEKDMMKKEITKEREYMGSKMLILSQNIA
QLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHREFRAKTNRDLEIKDQEIEKLRIELDESKQH
LEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQELTQKIQQMEAQHDKTENEQYLLLTSQNTFL
TKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHETMKQRLRQLDKHSQATAQQLVQLLSKQNQ

--------------------------------------------------------------
>In-frame_ENST00000488653_ENST00000391846_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(transcript)=673nt_BP=265nt
GACAAGCCGGGAAGCTTGGAGGGGTCTATTGCGTACGCCCAAGGCGCTGGGCCTGGAGCAGGAGAAAGGGAGTGGAGGCGCGTCGGAGAC
TATGAAGCGCGGCATTCGGCGGGATCCTTTCCGGAAGCGGAAGCTCGGCGGGCGGGCCAAGAAGGTCCGGGAGCCCACGGCGGTTAATTC
TTTTTACCGTGAGGCTTCACTTCCCTCGGTCTGGGCTTCTCTGAGGCGGCGAGAGATGGTCAGGTCTGGAGCTCGACCGGGCCAGGAGAA
GCTAAAACTTACTTATGAGGAAAAGTGTGAAATTGAGGAATCCCAATTGAAGTTTTTGAGGAACGACTTAGCTGAATATCAGAGAACTTG
TGAAGATCTTAAAGAGCAACTAAAGCATAAAGAATTTCTTCTGGCTGCTAATACTTGTAACCGTGTTGGTGGTCTTTGTTTGAAATGTGC
TCAGCATGAAGCTGTTCTTTCCCAAACCCATACTAATGTTCATATGCAGACCATCGAAAGACTGGTTAAAGAAAGAGATGACTTGATGTC
TGCACTAGTTTCCGTAAGGAGCAGCTTGGCAGATACGCAGCAAAGAGAAGCAAGTGCTTATGAACAGGTGAAACAAGTTTTGCAAATATC

>In-frame_ENST00000488653_ENST00000391846_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(amino acids)=215AA_start in transcript=28_stop in transcript=672
MRTPKALGLEQEKGSGGASETMKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSVWASLRRREMVRSGARPGQEKLKLTYEEKC
EIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTHTNVHMQTIERLVKERDDLMSALVSVRSSL

--------------------------------------------------------------
>In-frame_ENST00000433542_ENST00000355875_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(transcript)=2342nt_BP=574nt
AACAACCCCGAGGTCTTATTTTTATAGAATATCAAGAACAAAATCTTCCAAAAGGCACACGATGCCAAACTAAAAATAAAGAGCGAAAAC
CCAAAAAGTCGCGCTCAATTCCTTCTGAAACCTATTCGCCTCCTACCCCTGTCCCATCCTCTGGCGCTGGCGGGTCCTCGTCCCCGTTTT
CCCCACCGCAAGTCCTGGAACCTCCGCTTAACTCTTTTCTCGGCGGCTCCGCCCCGGCCCCGCCCCAGCCATGCCTTGGCCCCGCCCCGT
TCGCCGTTTATTGGCTTCTCCCAACCCCTGCCGGTGGGTGACAAGCCGGGAAGCTTGGAGGGGTCTATTGCGTACGCCCAAGGCGCTGGG
CCTGGAGCAGGAGAAAGGGAGTGGAGGCGCGTCGGAGACTATGAAGCGCGGCATTCGGCGGGATCCTTTCCGGAAGCGGAAGCTCGGCGG
GCGGGCCAAGAAGGTCCGGGAGCCCACGGCGGTTAATTCTTTTTACCGTGAGGCTTCACTTCCCTCGGTCTGGGCTTCTCTGAGGCGGCG
AGAGATGGTCAGGTCTGGAGCTCGACCGGGCCAGGAGAAGCTAAAACTTACTTATGAGGAAAAGTGTGAAATTGAGGAATCCCAATTGAA
GTTTTTGAGGAACGACTTAGCTGAATATCAGAGAACTTGTGAAGATCTTAAAGAGCAACTAAAGCATAAAGAATTTCTTCTGGCTGCTAA
TACTTGTAACCGTGTTGGTGGTCTTTGTTTGAAATGTGCTCAGCATGAAGCTGTTCTTTCCCAAACCCATACTAATGTTCATATGCAGAC
CATCGAAAGACTGGTTAAAGAAAGAGATGACTTGATGTCTGCACTAGTTTCCGTAAGGAGCAGCTTGGCAGATACGCAGCAAAGAGAAGC
AAGTGCTTATGAACAGGTGAAACAAGTTTTGCAAATATCTGAGGAAGCCAATTTTGAAAAAACCAAGGCTTTAATCCAGTGTGACCAGTT
GAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAA
AAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAA
GGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTG
TGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAG
GGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGC
AGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAG
CATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAAT
GGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTG
TACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAA
ATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAG
GCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCT
GTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGAT
TTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCA
GTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGT
GTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACATATGATTTTCAATAAATGAACTTT

>In-frame_ENST00000433542_ENST00000355875_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(amino acids)=596AA_start in transcript=250_stop in transcript=2040
MPWPRPVRRLLASPNPCRWVTSREAWRGLLRTPKALGLEQEKGSGGASETMKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSV
WASLRRREMVRSGARPGQEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTH
TNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRA
IEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHRE
FRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQEL
TQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHE

--------------------------------------------------------------
>In-frame_ENST00000433542_ENST00000366541_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(transcript)=2348nt_BP=574nt
AACAACCCCGAGGTCTTATTTTTATAGAATATCAAGAACAAAATCTTCCAAAAGGCACACGATGCCAAACTAAAAATAAAGAGCGAAAAC
CCAAAAAGTCGCGCTCAATTCCTTCTGAAACCTATTCGCCTCCTACCCCTGTCCCATCCTCTGGCGCTGGCGGGTCCTCGTCCCCGTTTT
CCCCACCGCAAGTCCTGGAACCTCCGCTTAACTCTTTTCTCGGCGGCTCCGCCCCGGCCCCGCCCCAGCCATGCCTTGGCCCCGCCCCGT
TCGCCGTTTATTGGCTTCTCCCAACCCCTGCCGGTGGGTGACAAGCCGGGAAGCTTGGAGGGGTCTATTGCGTACGCCCAAGGCGCTGGG
CCTGGAGCAGGAGAAAGGGAGTGGAGGCGCGTCGGAGACTATGAAGCGCGGCATTCGGCGGGATCCTTTCCGGAAGCGGAAGCTCGGCGG
GCGGGCCAAGAAGGTCCGGGAGCCCACGGCGGTTAATTCTTTTTACCGTGAGGCTTCACTTCCCTCGGTCTGGGCTTCTCTGAGGCGGCG
AGAGATGGTCAGGTCTGGAGCTCGACCGGGCCAGGAGAAGCTAAAACTTACTTATGAGGAAAAGTGTGAAATTGAGGAATCCCAATTGAA
GTTTTTGAGGAACGACTTAGCTGAATATCAGAGAACTTGTGAAGATCTTAAAGAGCAACTAAAGCATAAAGAATTTCTTCTGGCTGCTAA
TACTTGTAACCGTGTTGGTGGTCTTTGTTTGAAATGTGCTCAGCATGAAGCTGTTCTTTCCCAAACCCATACTAATGTTCATATGCAGAC
CATCGAAAGACTGGTTAAAGAAAGAGATGACTTGATGTCTGCACTAGTTTCCGTAAGGAGCAGCTTGGCAGATACGCAGCAAAGAGAAGC
AAGTGCTTATGAACAGGTGAAACAAGTTTTGCAAATATCTGAGGAAGCCAATTTTGAAAAAACCAAGGCTTTAATCCAGTGTGACCAGTT
GAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAA
AAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAA
GGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTG
TGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAG
GGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGC
AGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAG
CATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAAT
GGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTG
TACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAA
ATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAG
GCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCT
GTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGAT
TTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCA
GTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGT
GTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACATATGATTTTCAATAAATGAACTTT

>In-frame_ENST00000433542_ENST00000366541_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(amino acids)=596AA_start in transcript=250_stop in transcript=2040
MPWPRPVRRLLASPNPCRWVTSREAWRGLLRTPKALGLEQEKGSGGASETMKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSV
WASLRRREMVRSGARPGQEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTH
TNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRA
IEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHRE
FRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQEL
TQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHE

--------------------------------------------------------------
>In-frame_ENST00000433542_ENST00000343783_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(transcript)=2346nt_BP=574nt
AACAACCCCGAGGTCTTATTTTTATAGAATATCAAGAACAAAATCTTCCAAAAGGCACACGATGCCAAACTAAAAATAAAGAGCGAAAAC
CCAAAAAGTCGCGCTCAATTCCTTCTGAAACCTATTCGCCTCCTACCCCTGTCCCATCCTCTGGCGCTGGCGGGTCCTCGTCCCCGTTTT
CCCCACCGCAAGTCCTGGAACCTCCGCTTAACTCTTTTCTCGGCGGCTCCGCCCCGGCCCCGCCCCAGCCATGCCTTGGCCCCGCCCCGT
TCGCCGTTTATTGGCTTCTCCCAACCCCTGCCGGTGGGTGACAAGCCGGGAAGCTTGGAGGGGTCTATTGCGTACGCCCAAGGCGCTGGG
CCTGGAGCAGGAGAAAGGGAGTGGAGGCGCGTCGGAGACTATGAAGCGCGGCATTCGGCGGGATCCTTTCCGGAAGCGGAAGCTCGGCGG
GCGGGCCAAGAAGGTCCGGGAGCCCACGGCGGTTAATTCTTTTTACCGTGAGGCTTCACTTCCCTCGGTCTGGGCTTCTCTGAGGCGGCG
AGAGATGGTCAGGTCTGGAGCTCGACCGGGCCAGGAGAAGCTAAAACTTACTTATGAGGAAAAGTGTGAAATTGAGGAATCCCAATTGAA
GTTTTTGAGGAACGACTTAGCTGAATATCAGAGAACTTGTGAAGATCTTAAAGAGCAACTAAAGCATAAAGAATTTCTTCTGGCTGCTAA
TACTTGTAACCGTGTTGGTGGTCTTTGTTTGAAATGTGCTCAGCATGAAGCTGTTCTTTCCCAAACCCATACTAATGTTCATATGCAGAC
CATCGAAAGACTGGTTAAAGAAAGAGATGACTTGATGTCTGCACTAGTTTCCGTAAGGAGCAGCTTGGCAGATACGCAGCAAAGAGAAGC
AAGTGCTTATGAACAGGTGAAACAAGTTTTGCAAATATCTGAGGAAGCCAATTTTGAAAAAACCAAGGCTTTAATCCAGTGTGACCAGTT
GAGGAAGGAGCTGGAGAGGCAGGCGGAGCGACTTGAAAAAGAACTTGCATCTCAGCAAGAGAAAAGGGCCATTGAGAAAGACATGATGAA
AAAGGAAATAACGAAAGAAAGGGAGTACATGGGATCAAAGATGTTGATCTTGTCTCAGAATATTGCCCAACTGGAGGCCCAGGTGGAAAA
GGTTACAAAGGAAAAGATTTCAGCTATTAATCAACTGGAGGAAATTCAAAGCCAGCTGGCTTCTCGGGAAATGGATGTCACAAAGGTGTG
TGGAGAAATGCGCTATCAGCTGAATAAAACCAACATGGAGAAGGATGAGGCAGAAAAGGAGCACAGAGAGTTCAGAGCAAAAACTAACAG
GGATCTTGAAATTAAAGATCAGGAAATAGAGAAATTGAGAATAGAACTGGATGAAAGCAAACAACACTTGGAACAGGAGCAGCAGAAGGC
AGCCCTGGCCAGAGAGGAGTGCCTGAGACTAACAGAACTGCTGGGCGAATCTGAGCACCAACTGCACCTCACCAGACAGGAAAAAGATAG
CATTCAGCAGAGCTTTAGCAAGGAAGCAAAGGCCCAAGCCCTTCAGGCCCAGCAAAGAGAGCAGGAGCTGACACAGAAGATACAGCAAAT
GGAGGCCCAGCATGACAAAACTGAAAATGAACAGTATTTGTTGCTGACCTCCCAGAATACATTTTTGACAAAGTTAAAGGAAGAATGCTG
TACATTAGCCAAGAAACTGGAACAAATCTCTCAAAAAACCAGATCTGAAATAGCTCAACTCAGTCAAGAAAAAAGGTATACATATGATAA
ATTGGGAAAGTTACAGAGAAGAAATGAAGAATTGGAGGAACAGTGTGTCCAGCATGGGAGAGTACATGAGACGATGAAGCAAAGGCTAAG
GCAGCTGGATAAGCACAGCCAGGCCACAGCCCAGCAGCTGGTGCAGCTCCTCAGCAAGCAGAACCAGCTTCTCCTGGAGAGGCAGAGCCT
GTCGGAAGAGGTGGACCGGCTGCGGACCCAGTTACCCAGCATGCCACAATCTGATTGCTGACCTGGATGGAACAGAGTGAAATAAATGAT
TTACAAAGAGATATTTACATTCATCTGGTTTAGACTTAATATGCCACAACGCACCACGACCTTCCCAGGGTGACACCGCCTCAGCCTGCA
GTGGGGCTGGTCCTCATCAACGCGGGCGCTGTCCCCGCACGCAGTCGGGCTGGAGCTGGAGTCTGACTCTAGCTGAGCAGAGCTCCTGGT
GTATGTTTTCAGAAATGGCTTGAAGTTATGTGTTTAAATCTGCTCATTCGTATGCTAGGTTATACATATGATTTTCAATAAATGAACTTT

>In-frame_ENST00000433542_ENST00000343783_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(amino acids)=596AA_start in transcript=250_stop in transcript=2040
MPWPRPVRRLLASPNPCRWVTSREAWRGLLRTPKALGLEQEKGSGGASETMKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSV
WASLRRREMVRSGARPGQEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTH
TNVHMQTIERLVKERDDLMSALVSVRSSLADTQQREASAYEQVKQVLQISEEANFEKTKALIQCDQLRKELERQAERLEKELASQQEKRA
IEKDMMKKEITKEREYMGSKMLILSQNIAQLEAQVEKVTKEKISAINQLEEIQSQLASREMDVTKVCGEMRYQLNKTNMEKDEAEKEHRE
FRAKTNRDLEIKDQEIEKLRIELDESKQHLEQEQQKAALAREECLRLTELLGESEHQLHLTRQEKDSIQQSFSKEAKAQALQAQQREQEL
TQKIQQMEAQHDKTENEQYLLLTSQNTFLTKLKEECCTLAKKLEQISQKTRSEIAQLSQEKRYTYDKLGKLQRRNEELEEQCVQHGRVHE

--------------------------------------------------------------
>In-frame_ENST00000433542_ENST00000391846_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(transcript)=982nt_BP=574nt
AACAACCCCGAGGTCTTATTTTTATAGAATATCAAGAACAAAATCTTCCAAAAGGCACACGATGCCAAACTAAAAATAAAGAGCGAAAAC
CCAAAAAGTCGCGCTCAATTCCTTCTGAAACCTATTCGCCTCCTACCCCTGTCCCATCCTCTGGCGCTGGCGGGTCCTCGTCCCCGTTTT
CCCCACCGCAAGTCCTGGAACCTCCGCTTAACTCTTTTCTCGGCGGCTCCGCCCCGGCCCCGCCCCAGCCATGCCTTGGCCCCGCCCCGT
TCGCCGTTTATTGGCTTCTCCCAACCCCTGCCGGTGGGTGACAAGCCGGGAAGCTTGGAGGGGTCTATTGCGTACGCCCAAGGCGCTGGG
CCTGGAGCAGGAGAAAGGGAGTGGAGGCGCGTCGGAGACTATGAAGCGCGGCATTCGGCGGGATCCTTTCCGGAAGCGGAAGCTCGGCGG
GCGGGCCAAGAAGGTCCGGGAGCCCACGGCGGTTAATTCTTTTTACCGTGAGGCTTCACTTCCCTCGGTCTGGGCTTCTCTGAGGCGGCG
AGAGATGGTCAGGTCTGGAGCTCGACCGGGCCAGGAGAAGCTAAAACTTACTTATGAGGAAAAGTGTGAAATTGAGGAATCCCAATTGAA
GTTTTTGAGGAACGACTTAGCTGAATATCAGAGAACTTGTGAAGATCTTAAAGAGCAACTAAAGCATAAAGAATTTCTTCTGGCTGCTAA
TACTTGTAACCGTGTTGGTGGTCTTTGTTTGAAATGTGCTCAGCATGAAGCTGTTCTTTCCCAAACCCATACTAATGTTCATATGCAGAC
CATCGAAAGACTGGTTAAAGAAAGAGATGACTTGATGTCTGCACTAGTTTCCGTAAGGAGCAGCTTGGCAGATACGCAGCAAAGAGAAGC

>In-frame_ENST00000433542_ENST00000391846_AA328928_CCDC14_chr3_123679990_-_SDCCAG8_chr1_243468013_length(amino acids)=244AA_start in transcript=250_stop in transcript=981
MPWPRPVRRLLASPNPCRWVTSREAWRGLLRTPKALGLEQEKGSGGASETMKRGIRRDPFRKRKLGGRAKKVREPTAVNSFYREASLPSV
WASLRRREMVRSGARPGQEKLKLTYEEKCEIEESQLKFLRNDLAEYQRTCEDLKEQLKHKEFLLAANTCNRVGGLCLKCAQHEAVLSQTH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCDC14-SDCCAG8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCDC14-SDCCAG8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCDC14-SDCCAG8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSDCCAG8C3150877SENIOR-LOKEN SYNDROME 73GENOMICS_ENGLAND
TgeneSDCCAG8C3889474BARDET-BIEDL SYNDROME 163CTD_human;GENOMICS_ENGLAND
TgeneSDCCAG8C0403553Renal dysplasia and retinal aplasia (disorder)2GENOMICS_ENGLAND;ORPHANET
TgeneSDCCAG8C0752166Bardet-Biedl Syndrome2GENOMICS_ENGLAND;ORPHANET
TgeneSDCCAG8C0022679Cystic kidney1CTD_human
TgeneSDCCAG8C0035309Retinal Diseases1CTD_human
TgeneSDCCAG8C0036341Schizophrenia1PSYGENET
TgeneSDCCAG8C1691228Cystic Kidney Diseases1CTD_human
TgeneSDCCAG8C3714756Intellectual Disability1GENOMICS_ENGLAND