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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCDC91-LYRM5 (FusionGDB2 ID:14039)

Fusion Gene Summary for CCDC91-LYRM5

check button Fusion gene summary
Fusion gene informationFusion gene name: CCDC91-LYRM5
Fusion gene ID: 14039
HgeneTgene
Gene symbol

CCDC91

LYRM5

Gene ID

55297

144363

Gene namecoiled-coil domain containing 91electron transfer flavoprotein regulatory factor 1
SynonymsHSD8|p56LYRM5
Cytomap

12p11.22

12p12.1

Type of geneprotein-codingprotein-coding
Descriptioncoiled-coil domain-containing protein 91GGA-binding partnerp56 accessory proteinelectron transfer flavoprotein regulatory factor 1LYR motif containing 5LYR motif-containing protein 5
Modification date2020031320200313
UniProtAcc

Q7Z6B0

.
Ensembl transtripts involved in fusion geneENST00000539107, ENST00000545336, 
ENST00000381256, ENST00000381259, 
ENST00000540401, ENST00000306172, 
ENST00000381356, ENST00000557540, 
ENST00000555711, ENST00000556885, 
ENST00000554266, ENST00000556351, 
ENST00000556927, ENST00000555151, 
ENST00000556402, ENST00000553788, 
Fusion gene scores* DoF score17 X 9 X 9=13773 X 3 X 2=18
# samples 174
** MAII scorelog2(17/1377*10)=-3.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CCDC91 [Title/Abstract] AND LYRM5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCDC91(28544344)-LYRM5(25357025), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CCDC91 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across LYRM5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A1AH-01ACCDC91chr12

28544344

+LYRM5chr12

25357025

+
ChimerDB4BRCATCGA-AR-A1AH-01ACCDC91chr12

28544344

-LYRM5chr12

25357025

+


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Fusion Gene ORF analysis for CCDC91-LYRM5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000539107ENST00000381356CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3CDSENST00000539107ENST00000557540CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3CDSENST00000539107ENST00000555711CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3CDSENST00000539107ENST00000556885CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3UTRENST00000539107ENST00000554266CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3UTRENST00000539107ENST00000556351CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3UTRENST00000539107ENST00000556927CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-intronENST00000539107ENST00000555151CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3UTRENST00000539107ENST00000556402CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-intronENST00000539107ENST00000553788CCDC91chr12

28544344

+LYRM5chr12

25357025

+
In-frameENST00000545336ENST00000381356CCDC91chr12

28544344

+LYRM5chr12

25357025

+
Frame-shiftENST00000545336ENST00000557540CCDC91chr12

28544344

+LYRM5chr12

25357025

+
In-frameENST00000545336ENST00000555711CCDC91chr12

28544344

+LYRM5chr12

25357025

+
Frame-shiftENST00000545336ENST00000556885CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000545336ENST00000554266CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000545336ENST00000556351CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000545336ENST00000556927CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-intronENST00000545336ENST00000555151CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000545336ENST00000556402CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-intronENST00000545336ENST00000553788CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3CDSENST00000381256ENST00000381356CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3CDSENST00000381256ENST00000557540CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3CDSENST00000381256ENST00000555711CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3CDSENST00000381256ENST00000556885CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3UTRENST00000381256ENST00000554266CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3UTRENST00000381256ENST00000556351CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3UTRENST00000381256ENST00000556927CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-intronENST00000381256ENST00000555151CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-3UTRENST00000381256ENST00000556402CCDC91chr12

28544344

+LYRM5chr12

25357025

+
intron-intronENST00000381256ENST00000553788CCDC91chr12

28544344

+LYRM5chr12

25357025

+
In-frameENST00000381259ENST00000381356CCDC91chr12

28544344

+LYRM5chr12

25357025

+
Frame-shiftENST00000381259ENST00000557540CCDC91chr12

28544344

+LYRM5chr12

25357025

+
In-frameENST00000381259ENST00000555711CCDC91chr12

28544344

+LYRM5chr12

25357025

+
Frame-shiftENST00000381259ENST00000556885CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000381259ENST00000554266CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000381259ENST00000556351CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000381259ENST00000556927CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-intronENST00000381259ENST00000555151CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000381259ENST00000556402CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-intronENST00000381259ENST00000553788CCDC91chr12

28544344

+LYRM5chr12

25357025

+
3UTR-3CDSENST00000540401ENST00000381356CCDC91chr12

28544344

+LYRM5chr12

25357025

+
3UTR-3CDSENST00000540401ENST00000557540CCDC91chr12

28544344

+LYRM5chr12

25357025

+
3UTR-3CDSENST00000540401ENST00000555711CCDC91chr12

28544344

+LYRM5chr12

25357025

+
3UTR-3CDSENST00000540401ENST00000556885CCDC91chr12

28544344

+LYRM5chr12

25357025

+
3UTR-3UTRENST00000540401ENST00000554266CCDC91chr12

28544344

+LYRM5chr12

25357025

+
3UTR-3UTRENST00000540401ENST00000556351CCDC91chr12

28544344

+LYRM5chr12

25357025

+
3UTR-3UTRENST00000540401ENST00000556927CCDC91chr12

28544344

+LYRM5chr12

25357025

+
3UTR-intronENST00000540401ENST00000555151CCDC91chr12

28544344

+LYRM5chr12

25357025

+
3UTR-3UTRENST00000540401ENST00000556402CCDC91chr12

28544344

+LYRM5chr12

25357025

+
3UTR-intronENST00000540401ENST00000553788CCDC91chr12

28544344

+LYRM5chr12

25357025

+
In-frameENST00000306172ENST00000381356CCDC91chr12

28544344

+LYRM5chr12

25357025

+
Frame-shiftENST00000306172ENST00000557540CCDC91chr12

28544344

+LYRM5chr12

25357025

+
In-frameENST00000306172ENST00000555711CCDC91chr12

28544344

+LYRM5chr12

25357025

+
Frame-shiftENST00000306172ENST00000556885CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000306172ENST00000554266CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000306172ENST00000556351CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000306172ENST00000556927CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-intronENST00000306172ENST00000555151CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-3UTRENST00000306172ENST00000556402CCDC91chr12

28544344

+LYRM5chr12

25357025

+
5CDS-intronENST00000306172ENST00000553788CCDC91chr12

28544344

+LYRM5chr12

25357025

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545336CCDC91chr1228544344+ENST00000381356LYRM5chr1225357025+210511814191402327
ENST00000545336CCDC91chr1228544344+ENST00000555711LYRM5chr1225357025+177311814191237272
ENST00000381259CCDC91chr1228544344+ENST00000381356LYRM5chr1225357025+170277816999327
ENST00000381259CCDC91chr1228544344+ENST00000555711LYRM5chr1225357025+137077816834272
ENST00000306172CCDC91chr1228544344+ENST00000381356LYRM5chr1225357025+15966720893297
ENST00000306172CCDC91chr1228544344+ENST00000555711LYRM5chr1225357025+12646720728242

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545336ENST00000381356CCDC91chr1228544344+LYRM5chr1225357025+0.0001664510.99983346
ENST00000545336ENST00000555711CCDC91chr1228544344+LYRM5chr1225357025+0.0004602220.99953985
ENST00000381259ENST00000381356CCDC91chr1228544344+LYRM5chr1225357025+0.0001777630.9998223
ENST00000381259ENST00000555711CCDC91chr1228544344+LYRM5chr1225357025+0.0005498380.99945015
ENST00000306172ENST00000381356CCDC91chr1228544344+LYRM5chr1225357025+0.0006449640.999355
ENST00000306172ENST00000555711CCDC91chr1228544344+LYRM5chr1225357025+0.0023403540.9976597

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Fusion Genomic Features for CCDC91-LYRM5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CCDC91chr1228544344+LYRM5chr1225357024+4.29E-050.9999571
CCDC91chr1228544344+LYRM5chr1225357024+4.29E-050.9999571

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCDC91-LYRM5


check button Go to

FGviewer for the breakpoints of chr12:28544344-chr12:25357025

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCDC91

Q7Z6B0

.
FUNCTION: Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. {ECO:0000269|PubMed:17596511}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC91chr12:28544344chr12:25357025ENST00000306172+611130_209224.0412.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr12:25357025ENST00000381259+712130_209254.0442.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr12:25357025ENST00000545336+1116130_209254.0442.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr12:25357025ENST00000306172+6111_16224.0412.0RegionNote=GGA1-binding motif
HgeneCCDC91chr12:28544344chr12:25357025ENST00000381259+7121_16254.0442.0RegionNote=GGA1-binding motif
HgeneCCDC91chr12:28544344chr12:25357025ENST00000545336+11161_16254.0442.0RegionNote=GGA1-binding motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCDC91chr12:28544344chr12:25357025ENST00000306172+611249_407224.0412.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr12:25357025ENST00000381256+111130_2090406.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr12:25357025ENST00000381256+111249_4070406.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr12:25357025ENST00000381259+712249_407254.0442.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr12:25357025ENST00000539107+112130_2090406.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr12:25357025ENST00000539107+112249_4070406.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr12:25357025ENST00000545336+1116249_407254.0442.0Coiled coilOntology_term=ECO:0000255
HgeneCCDC91chr12:28544344chr12:25357025ENST00000306172+611210_413224.0412.0RegionNote=Homodimerization
HgeneCCDC91chr12:28544344chr12:25357025ENST00000381256+1111_160406.0RegionNote=GGA1-binding motif
HgeneCCDC91chr12:28544344chr12:25357025ENST00000381256+111210_4130406.0RegionNote=Homodimerization
HgeneCCDC91chr12:28544344chr12:25357025ENST00000381259+712210_413254.0442.0RegionNote=Homodimerization
HgeneCCDC91chr12:28544344chr12:25357025ENST00000539107+1121_160406.0RegionNote=GGA1-binding motif
HgeneCCDC91chr12:28544344chr12:25357025ENST00000539107+112210_4130406.0RegionNote=Homodimerization
HgeneCCDC91chr12:28544344chr12:25357025ENST00000545336+1116210_413254.0442.0RegionNote=Homodimerization


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Fusion Gene Sequence for CCDC91-LYRM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000545336_ENST00000381356_TCGA-AR-A1AH-01A_CCDC91_chr12_28544344_+_LYRM5_chr12_25357025_length(transcript)=2105nt_BP=1181nt
TTCCGGGGGCAGAGGTGTTCGAAGCCGGGTGGTGCGTGGGCTACCCCAACCTGTGTGGCTGGGCCGCGGTCTCCCCTCAAGGGCCTGGGG
CCGTGCCTCGGGTGTACGCGTAGGGGTCTGTGTGCTGGGGGTGGCTCACCGGGCAGCGTGGGTGAGCGGCGCAGCGGCGGCAGCGGAGAG
CGAGAGAGGGGAGCAGGCTTCTAACCCTCCTTTATGTGACTCAGAGAAAGGAGACCTCATTCCAAGTTCCAGGATTAATTCTGATGAAAG
TATTCTGTCTCATGCATCTAATACTTTACTTGTGAATGAAGATTCATTATGAGGTGCTATACGTGGATGACCTGCTTAGTTTTAATTTTT
GGAGAAATACATTTTATAAAACATTTTCATCAGATTGCTAAAATTGTGCCACTTGAAGAATGGATGATGATGATTTTGGTGGTTTTGAGG
CTGCGGAGACTTTTGATGGTGGAAGTGGTGAAACCCAAACAACATCTCCTGCTATTCCTTGGGCTGCCTTTCCTGCAGTATCTGGAGTCC
ATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCACTCTTCTTCCATTGGCTGCCTCTCTTCTGATGCCATTATTTCATCAC
CAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTATTCCAAAAGCACAGATTCAGCAATCAACACACACTCATCTGGATATCT
CACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAACAATTGCCCTTGTGGATGATTCTGAGGATCCTGGAGCCAATGTATCTA
ACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACTCAAAGTATCTGAAGAAGAAAAACAGAGAATTAAACAGGATGTGGAAT
CATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAAAGAAAAAGAGCAAGAGGCCATTTCTTTTCAAGATAGATACAAAGAAC
TTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGCTGGTCACGAAGCCCTCAGCATTATTGTGGATGAATATAAGGCACTAC
TGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACAGTACATTTCTGCAATTGAGAAACAGGCACACAAGTGTGAGGAGTTGC
TAAATGCTCAGCTGCTGTATCTTGGACGAGACTATCCAAAAGGAGCAGACTATTTTAAAAAGCGTTTGAAGAACATTTTCCTTAAAAACA
AAGATGTGAAGAATCCAGAGAAGATCAAAGAACTTATTGCACAGGGCGAATTTGTAATGAAAGAGCTAGAAGCTTTGTACTTCCTTAGGA
AATACAGAGCTATGAAACAACGCTATTATTCAGATACCAACAAAACTAATTGATCATTACTACTTTAATTTAGCTATCAGTGCCAGCTGT
TTATGTATACCAGATGTTGTAAAATAATTCTAACTTAAAATGGGAAGATATACATGTTGTGTAAAAAATCCCTGAGCTGCCCTACTGAAC
TAAATAGGTTTCAACTTCTGTTCATACGGAGAAAGTATCAGCAACTTTATGCTCAATTTTGATACAAACATAGCAATTTAGCTATACTAC
CGATCATAAATTAATGAGCACCCAATTTTGAATGAAAATATAATACACTTAATCCTCTAACTTAATAGGACTTAGCCAATTATTTTTAGC
TTATTTCTCCATTTTACTGACAAGAGAATGCCATTTACCGAACATTTAATAAGCAAAATAATTTCTTACACACTTACTTCTCTTAACTTT
TGAAAGGAATCCCTTATTTTTTCACCCAATTTGGTATATTAACAGCACATACTCAAGGTTCACTACAAAACAAACAGTTCCTGGTAATGA
TTTAAATGTAGTTATAGAAATAAATAATATGTATGGAGTCATTACTTCTGACCTTGAAATAGCCTGCTGGTGACTGGCATTAACATACAT
AACTAACTATTCAATTATTTCCATTATTAATGTTGCTGCTGCTACCTTTGGGCCTAAAACCAAGTCACCTGTTGTGTATCAATTACCTTC

>In-frame_ENST00000545336_ENST00000381356_TCGA-AR-A1AH-01A_CCDC91_chr12_28544344_+_LYRM5_chr12_25357025_length(amino acids)=327AA_start in transcript=419_stop in transcript=1402
MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQI
QQSTHTHLDISLFPLGLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQE
AISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQLLYLGRDYPKGADYFK

--------------------------------------------------------------
>In-frame_ENST00000545336_ENST00000555711_TCGA-AR-A1AH-01A_CCDC91_chr12_28544344_+_LYRM5_chr12_25357025_length(transcript)=1773nt_BP=1181nt
TTCCGGGGGCAGAGGTGTTCGAAGCCGGGTGGTGCGTGGGCTACCCCAACCTGTGTGGCTGGGCCGCGGTCTCCCCTCAAGGGCCTGGGG
CCGTGCCTCGGGTGTACGCGTAGGGGTCTGTGTGCTGGGGGTGGCTCACCGGGCAGCGTGGGTGAGCGGCGCAGCGGCGGCAGCGGAGAG
CGAGAGAGGGGAGCAGGCTTCTAACCCTCCTTTATGTGACTCAGAGAAAGGAGACCTCATTCCAAGTTCCAGGATTAATTCTGATGAAAG
TATTCTGTCTCATGCATCTAATACTTTACTTGTGAATGAAGATTCATTATGAGGTGCTATACGTGGATGACCTGCTTAGTTTTAATTTTT
GGAGAAATACATTTTATAAAACATTTTCATCAGATTGCTAAAATTGTGCCACTTGAAGAATGGATGATGATGATTTTGGTGGTTTTGAGG
CTGCGGAGACTTTTGATGGTGGAAGTGGTGAAACCCAAACAACATCTCCTGCTATTCCTTGGGCTGCCTTTCCTGCAGTATCTGGAGTCC
ATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCACTCTTCTTCCATTGGCTGCCTCTCTTCTGATGCCATTATTTCATCAC
CAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTATTCCAAAAGCACAGATTCAGCAATCAACACACACTCATCTGGATATCT
CACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAACAATTGCCCTTGTGGATGATTCTGAGGATCCTGGAGCCAATGTATCTA
ACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACTCAAAGTATCTGAAGAAGAAAAACAGAGAATTAAACAGGATGTGGAAT
CATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAAAGAAAAAGAGCAAGAGGCCATTTCTTTTCAAGATAGATACAAAGAAC
TTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGCTGGTCACGAAGCCCTCAGCATTATTGTGGATGAATATAAGGCACTAC
TGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACAGTACATTTCTGCAATTGAGAAACAGGCACACAAGTGTGAGGAGTTGC
TAAATGCTCAGTGCTGTATCTTGGACGAGACTATCCAAAAGGAGCAGACTATTTTAAAAAGCGTTTGAAGAACATTTTCCTTAAAAACAA
AGATGTGAAGAATCCAGAGAAGATCAAAGAACTTATTGCACAGGGCGAATTTGTAATGAAAGAGCTAGAAGCTTTGTACTTCCTTAGGAA
ATACAGAGCTATGAAACAACGCTATTATTCAGATACCAACAAAACTAATTGATCATTACTACTTTAATTTAGCTATCAGTGCCAGCTGTT
TATGTATACCAGATGTTGTAAAATAATTCTAACTTAAAATGGGAAGATATACATGTTGTGTAAAAAATCCCTGAGCTGCCCTACTGAACT
AAATAGGTTTCAACTTCTGTTCATACGGAGAAAGTATCAGCAACTTTATGCTCAATTTTGATACAAACATAGCAATTTAGCTATACTACC
GATCATAAATTAATGAGCACCCAATTTTGAATGAAAATATAATACACTTAATCCTCTAACTTAATAGGACTTAGCCAATTATTTTTAGCT

>In-frame_ENST00000545336_ENST00000555711_TCGA-AR-A1AH-01A_CCDC91_chr12_28544344_+_LYRM5_chr12_25357025_length(amino acids)=272AA_start in transcript=419_stop in transcript=1237
MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQI
QQSTHTHLDISLFPLGLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQE
AISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQCCILDETIQKEQTILK

--------------------------------------------------------------
>In-frame_ENST00000381259_ENST00000381356_TCGA-AR-A1AH-01A_CCDC91_chr12_28544344_+_LYRM5_chr12_25357025_length(transcript)=1702nt_BP=778nt
AGGTGCCACTTGAAGAATGGATGATGATGATTTTGGTGGTTTTGAGGCTGCGGAGACTTTTGATGGTGGAAGTGGTGAAACCCAAACAAC
ATCTCCTGCTATTCCTTGGGCTGCCTTTCCTGCAGTATCTGGAGTCCATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCA
CTCTTCTTCCATTGGCTGCCTCTCTTCTGATGCCATTATTTCATCACCAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTAT
TCCAAAAGCACAGATTCAGCAATCAACACACACTCATCTGGATATCTCACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAAC
AATTGCCCTTGTGGATGATTCTGAGGATCCTGGAGCCAATGTATCTAACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACT
CAAAGTATCTGAAGAAGAAAAACAGAGAATTAAACAGGATGTGGAATCATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAA
AGAAAAAGAGCAAGAGGCCATTTCTTTTCAAGATAGATACAAAGAACTTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGC
TGGTCACGAAGCCCTCAGCATTATTGTGGATGAATATAAGGCACTACTGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACA
GTACATTTCTGCAATTGAGAAACAGGCACACAAGTGTGAGGAGTTGCTAAATGCTCAGCTGCTGTATCTTGGACGAGACTATCCAAAAGG
AGCAGACTATTTTAAAAAGCGTTTGAAGAACATTTTCCTTAAAAACAAAGATGTGAAGAATCCAGAGAAGATCAAAGAACTTATTGCACA
GGGCGAATTTGTAATGAAAGAGCTAGAAGCTTTGTACTTCCTTAGGAAATACAGAGCTATGAAACAACGCTATTATTCAGATACCAACAA
AACTAATTGATCATTACTACTTTAATTTAGCTATCAGTGCCAGCTGTTTATGTATACCAGATGTTGTAAAATAATTCTAACTTAAAATGG
GAAGATATACATGTTGTGTAAAAAATCCCTGAGCTGCCCTACTGAACTAAATAGGTTTCAACTTCTGTTCATACGGAGAAAGTATCAGCA
ACTTTATGCTCAATTTTGATACAAACATAGCAATTTAGCTATACTACCGATCATAAATTAATGAGCACCCAATTTTGAATGAAAATATAA
TACACTTAATCCTCTAACTTAATAGGACTTAGCCAATTATTTTTAGCTTATTTCTCCATTTTACTGACAAGAGAATGCCATTTACCGAAC
ATTTAATAAGCAAAATAATTTCTTACACACTTACTTCTCTTAACTTTTGAAAGGAATCCCTTATTTTTTCACCCAATTTGGTATATTAAC
AGCACATACTCAAGGTTCACTACAAAACAAACAGTTCCTGGTAATGATTTAAATGTAGTTATAGAAATAAATAATATGTATGGAGTCATT
ACTTCTGACCTTGAAATAGCCTGCTGGTGACTGGCATTAACATACATAACTAACTATTCAATTATTTCCATTATTAATGTTGCTGCTGCT

>In-frame_ENST00000381259_ENST00000381356_TCGA-AR-A1AH-01A_CCDC91_chr12_28544344_+_LYRM5_chr12_25357025_length(amino acids)=327AA_start in transcript=16_stop in transcript=999
MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQI
QQSTHTHLDISLFPLGLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQE
AISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQLLYLGRDYPKGADYFK

--------------------------------------------------------------
>In-frame_ENST00000381259_ENST00000555711_TCGA-AR-A1AH-01A_CCDC91_chr12_28544344_+_LYRM5_chr12_25357025_length(transcript)=1370nt_BP=778nt
AGGTGCCACTTGAAGAATGGATGATGATGATTTTGGTGGTTTTGAGGCTGCGGAGACTTTTGATGGTGGAAGTGGTGAAACCCAAACAAC
ATCTCCTGCTATTCCTTGGGCTGCCTTTCCTGCAGTATCTGGAGTCCATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCA
CTCTTCTTCCATTGGCTGCCTCTCTTCTGATGCCATTATTTCATCACCAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTAT
TCCAAAAGCACAGATTCAGCAATCAACACACACTCATCTGGATATCTCACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAAC
AATTGCCCTTGTGGATGATTCTGAGGATCCTGGAGCCAATGTATCTAACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACT
CAAAGTATCTGAAGAAGAAAAACAGAGAATTAAACAGGATGTGGAATCATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAA
AGAAAAAGAGCAAGAGGCCATTTCTTTTCAAGATAGATACAAAGAACTTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGC
TGGTCACGAAGCCCTCAGCATTATTGTGGATGAATATAAGGCACTACTGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACA
GTACATTTCTGCAATTGAGAAACAGGCACACAAGTGTGAGGAGTTGCTAAATGCTCAGTGCTGTATCTTGGACGAGACTATCCAAAAGGA
GCAGACTATTTTAAAAAGCGTTTGAAGAACATTTTCCTTAAAAACAAAGATGTGAAGAATCCAGAGAAGATCAAAGAACTTATTGCACAG
GGCGAATTTGTAATGAAAGAGCTAGAAGCTTTGTACTTCCTTAGGAAATACAGAGCTATGAAACAACGCTATTATTCAGATACCAACAAA
ACTAATTGATCATTACTACTTTAATTTAGCTATCAGTGCCAGCTGTTTATGTATACCAGATGTTGTAAAATAATTCTAACTTAAAATGGG
AAGATATACATGTTGTGTAAAAAATCCCTGAGCTGCCCTACTGAACTAAATAGGTTTCAACTTCTGTTCATACGGAGAAAGTATCAGCAA
CTTTATGCTCAATTTTGATACAAACATAGCAATTTAGCTATACTACCGATCATAAATTAATGAGCACCCAATTTTGAATGAAAATATAAT
ACACTTAATCCTCTAACTTAATAGGACTTAGCCAATTATTTTTAGCTTATTTCTCCATTTTACTGACAAGAGAATGCCATTTACCGAACA

>In-frame_ENST00000381259_ENST00000555711_TCGA-AR-A1AH-01A_CCDC91_chr12_28544344_+_LYRM5_chr12_25357025_length(amino acids)=272AA_start in transcript=16_stop in transcript=834
MDDDDFGGFEAAETFDGGSGETQTTSPAIPWAAFPAVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQI
QQSTHTHLDISLFPLGLTDEKSNGTIALVDDSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQE
AISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQCCILDETIQKEQTILK

--------------------------------------------------------------
>In-frame_ENST00000306172_ENST00000381356_TCGA-AR-A1AH-01A_CCDC91_chr12_28544344_+_LYRM5_chr12_25357025_length(transcript)=1596nt_BP=672nt
ATGCCAATGTGGAATAAAGTATCTGGAGTCCATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCACTCTTCTTCCATTGGC
TGCCTCTCTTCTGATGCCATTATTTCATCACCAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTATTCCAAAAGCACAGATT
CAGCAATCAACACACACTCATCTGGATATCTCACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAACAATTGCCCTTGTGGAT
GATTCTGAGGATCCTGGAGCCAATGTATCTAACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACTCAAAGTATCTGAAGAA
GAAAAACAGAGAATTAAACAGGATGTGGAATCATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAAAGAAAAAGAGCAAGAG
GCCATTTCTTTTCAAGATAGATACAAAGAACTTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGCTGGTCACGAAGCCCTC
AGCATTATTGTGGATGAATATAAGGCACTACTGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACAGTACATTTCTGCAATT
GAGAAACAGGCACACAAGTGTGAGGAGTTGCTAAATGCTCAGCTGCTGTATCTTGGACGAGACTATCCAAAAGGAGCAGACTATTTTAAA
AAGCGTTTGAAGAACATTTTCCTTAAAAACAAAGATGTGAAGAATCCAGAGAAGATCAAAGAACTTATTGCACAGGGCGAATTTGTAATG
AAAGAGCTAGAAGCTTTGTACTTCCTTAGGAAATACAGAGCTATGAAACAACGCTATTATTCAGATACCAACAAAACTAATTGATCATTA
CTACTTTAATTTAGCTATCAGTGCCAGCTGTTTATGTATACCAGATGTTGTAAAATAATTCTAACTTAAAATGGGAAGATATACATGTTG
TGTAAAAAATCCCTGAGCTGCCCTACTGAACTAAATAGGTTTCAACTTCTGTTCATACGGAGAAAGTATCAGCAACTTTATGCTCAATTT
TGATACAAACATAGCAATTTAGCTATACTACCGATCATAAATTAATGAGCACCCAATTTTGAATGAAAATATAATACACTTAATCCTCTA
ACTTAATAGGACTTAGCCAATTATTTTTAGCTTATTTCTCCATTTTACTGACAAGAGAATGCCATTTACCGAACATTTAATAAGCAAAAT
AATTTCTTACACACTTACTTCTCTTAACTTTTGAAAGGAATCCCTTATTTTTTCACCCAATTTGGTATATTAACAGCACATACTCAAGGT
TCACTACAAAACAAACAGTTCCTGGTAATGATTTAAATGTAGTTATAGAAATAAATAATATGTATGGAGTCATTACTTCTGACCTTGAAA
TAGCCTGCTGGTGACTGGCATTAACATACATAACTAACTATTCAATTATTTCCATTATTAATGTTGCTGCTGCTACCTTTGGGCCTAAAA

>In-frame_ENST00000306172_ENST00000381356_TCGA-AR-A1AH-01A_CCDC91_chr12_28544344_+_LYRM5_chr12_25357025_length(amino acids)=297AA_start in transcript=0_stop in transcript=893
MPMWNKVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALVD
DSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEAL
SIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQLLYLGRDYPKGADYFKKRLKNIFLKNKDVKNPEKIKELIAQGEFVM

--------------------------------------------------------------
>In-frame_ENST00000306172_ENST00000555711_TCGA-AR-A1AH-01A_CCDC91_chr12_28544344_+_LYRM5_chr12_25357025_length(transcript)=1264nt_BP=672nt
ATGCCAATGTGGAATAAAGTATCTGGAGTCCATCTTTCACCATCTTCTCCTGAGATTGTACTGGACCGTGACCACTCTTCTTCCATTGGC
TGCCTCTCTTCTGATGCCATTATTTCATCACCAGAGAATACACATGCAGCAAATAGCATTGTGAGTCAAACTATTCCAAAAGCACAGATT
CAGCAATCAACACACACTCATCTGGATATCTCACTTTTTCCATTGGGTTTAACTGATGAAAAAAGTAATGGAACAATTGCCCTTGTGGAT
GATTCTGAGGATCCTGGAGCCAATGTATCTAACATACAGCTTCAGCAAAAAATTTCAAGTCTGGAGATTAAACTCAAAGTATCTGAAGAA
GAAAAACAGAGAATTAAACAGGATGTGGAATCATTGATGGAAAAGCATAATGTCTTAGAAAAAGGCTTTCTAAAAGAAAAAGAGCAAGAG
GCCATTTCTTTTCAAGATAGATACAAAGAACTTCAGGAAAAACATAAACAAGAATTGGAAGACATGAGGAAAGCTGGTCACGAAGCCCTC
AGCATTATTGTGGATGAATATAAGGCACTACTGCAGTCTTCAGTTAAGCAACAAGTAGAAGCTATTGAAAAACAGTACATTTCTGCAATT
GAGAAACAGGCACACAAGTGTGAGGAGTTGCTAAATGCTCAGTGCTGTATCTTGGACGAGACTATCCAAAAGGAGCAGACTATTTTAAAA
AGCGTTTGAAGAACATTTTCCTTAAAAACAAAGATGTGAAGAATCCAGAGAAGATCAAAGAACTTATTGCACAGGGCGAATTTGTAATGA
AAGAGCTAGAAGCTTTGTACTTCCTTAGGAAATACAGAGCTATGAAACAACGCTATTATTCAGATACCAACAAAACTAATTGATCATTAC
TACTTTAATTTAGCTATCAGTGCCAGCTGTTTATGTATACCAGATGTTGTAAAATAATTCTAACTTAAAATGGGAAGATATACATGTTGT
GTAAAAAATCCCTGAGCTGCCCTACTGAACTAAATAGGTTTCAACTTCTGTTCATACGGAGAAAGTATCAGCAACTTTATGCTCAATTTT
GATACAAACATAGCAATTTAGCTATACTACCGATCATAAATTAATGAGCACCCAATTTTGAATGAAAATATAATACACTTAATCCTCTAA
CTTAATAGGACTTAGCCAATTATTTTTAGCTTATTTCTCCATTTTACTGACAAGAGAATGCCATTTACCGAACATTTAATAAGCAAAATA

>In-frame_ENST00000306172_ENST00000555711_TCGA-AR-A1AH-01A_CCDC91_chr12_28544344_+_LYRM5_chr12_25357025_length(amino acids)=242AA_start in transcript=0_stop in transcript=728
MPMWNKVSGVHLSPSSPEIVLDRDHSSSIGCLSSDAIISSPENTHAANSIVSQTIPKAQIQQSTHTHLDISLFPLGLTDEKSNGTIALVD
DSEDPGANVSNIQLQQKISSLEIKLKVSEEEKQRIKQDVESLMEKHNVLEKGFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEAL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCDC91-LYRM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCDC91-LYRM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCDC91-LYRM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCDC91C0013146Drug abuse1CTD_human
HgeneCCDC91C0013170Drug habituation1CTD_human
HgeneCCDC91C0013222Drug Use Disorders1CTD_human
HgeneCCDC91C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneCCDC91C0038580Substance Dependence1CTD_human
HgeneCCDC91C0038586Substance Use Disorders1CTD_human
HgeneCCDC91C0236969Substance-Related Disorders1CTD_human
HgeneCCDC91C0740858Substance abuse problem1CTD_human
HgeneCCDC91C1510472Drug Dependence1CTD_human
HgeneCCDC91C4316881Prescription Drug Abuse1CTD_human