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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCM2-PDHA1 (FusionGDB2 ID:14102)

Fusion Gene Summary for CCM2-PDHA1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCM2-PDHA1
Fusion gene ID: 14102
HgeneTgene
Gene symbol

CCM2

PDHA1

Gene ID

83605

5160

Gene nameCCM2 scaffold proteinpyruvate dehydrogenase E1 subunit alpha 1
SynonymsC7orf22|OSM|PP10187PDHA|PDHAD|PDHCE1A|PHE1A
Cytomap

7p13

Xp22.12

Type of geneprotein-codingprotein-coding
Descriptioncerebral cavernous malformations 2 proteinCCM2 scaffolding proteincerebral cavernous malformation 2malcaverninosmosensing scaffold for MEKK3pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrialPDHE1-A type Ipyruvate dehydrogenase (lipoamide) alpha 1pyruvate dehydrogenase E1 alpha 1 subunitpyruvate dehydrogenase E1 subunitpyruvate dehydrogenase alpha 1pyruvate de
Modification date2020031320200313
UniProtAcc

Q9BSQ5

.
Ensembl transtripts involved in fusion geneENST00000461377, ENST00000258781, 
ENST00000544363, ENST00000541586, 
ENST00000475551, ENST00000381112, 
ENST00000474617, 		ENST00000545074, 
ENST00000540249, ENST00000379806, 
ENST00000422285, ENST00000379805, 
ENST00000379804, ENST00000478795, 
Fusion gene scores* DoF score9 X 5 X 6=2708 X 8 X 4=256
# samples 129
** MAII scorelog2(12/270*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/256*10)=-1.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCM2 [Title/Abstract] AND PDHA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCM2(45039962)-PDHA1(19375770), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePDHA1

GO:0006086

acetyl-CoA biosynthetic process from pyruvate

19081061


check buttonFusion gene breakpoints across CCM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PDHA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A56D-01ACCM2chr7

45039962

+PDHA1chrX

19375770

+
ChimerDB4BRCATCGA-A7-A56DCCM2chr7

45039962

+PDHA1chrX

19375769

+
ChimerDB4BRCATCGA-A7-A56D-01ACCM2chr7

45039962

+PDHA1chrX

19375770

+
ChimerDB4BRCATCGA-A7-A56D-01ACCM2chr7

45039456

+PDHA1chrX

19375770

+


Top

Fusion Gene ORF analysis for CCM2-PDHA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000461377ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000461377ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000461377ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000461377ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-intronENST00000461377ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-5UTRENST00000461377ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3UTRENST00000461377ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375770

+
In-frameENST00000258781ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375770

+
In-frameENST00000258781ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375770

+
In-frameENST00000258781ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375770

+
In-frameENST00000258781ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375770

+
5CDS-intronENST00000258781ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375770

+
5CDS-5UTRENST00000258781ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375770

+
5CDS-3UTRENST00000258781ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375770

+
In-frameENST00000544363ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375770

+
In-frameENST00000544363ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375770

+
In-frameENST00000544363ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375770

+
In-frameENST00000544363ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375770

+
5CDS-intronENST00000544363ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375770

+
5CDS-5UTRENST00000544363ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375770

+
5CDS-3UTRENST00000544363ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375770

+
In-frameENST00000541586ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375770

+
In-frameENST00000541586ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375770

+
In-frameENST00000541586ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375770

+
In-frameENST00000541586ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375770

+
5CDS-intronENST00000541586ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375770

+
5CDS-5UTRENST00000541586ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375770

+
5CDS-3UTRENST00000541586ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000475551ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000475551ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000475551ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000475551ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-intronENST00000475551ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-5UTRENST00000475551ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3UTRENST00000475551ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000381112ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000381112ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000381112ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000381112ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-intronENST00000381112ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-5UTRENST00000381112ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3UTRENST00000381112ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000474617ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000474617ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000474617ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000474617ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-intronENST00000474617ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-5UTRENST00000474617ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3UTRENST00000474617ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375770

+
intron-3CDSENST00000461377ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000461377ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000461377ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000461377ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-intronENST00000461377ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-5UTRENST00000461377ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3UTRENST00000461377ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375769

+
In-frameENST00000258781ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375769

+
In-frameENST00000258781ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375769

+
In-frameENST00000258781ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375769

+
In-frameENST00000258781ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375769

+
5CDS-intronENST00000258781ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375769

+
5CDS-5UTRENST00000258781ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375769

+
5CDS-3UTRENST00000258781ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375769

+
In-frameENST00000544363ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375769

+
In-frameENST00000544363ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375769

+
In-frameENST00000544363ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375769

+
In-frameENST00000544363ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375769

+
5CDS-intronENST00000544363ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375769

+
5CDS-5UTRENST00000544363ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375769

+
5CDS-3UTRENST00000544363ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375769

+
In-frameENST00000541586ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375769

+
In-frameENST00000541586ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375769

+
In-frameENST00000541586ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375769

+
In-frameENST00000541586ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375769

+
5CDS-intronENST00000541586ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375769

+
5CDS-5UTRENST00000541586ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375769

+
5CDS-3UTRENST00000541586ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000475551ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000475551ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000475551ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000475551ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-intronENST00000475551ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-5UTRENST00000475551ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3UTRENST00000475551ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000381112ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000381112ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000381112ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000381112ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-intronENST00000381112ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-5UTRENST00000381112ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3UTRENST00000381112ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000474617ENST00000545074CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000474617ENST00000540249CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000474617ENST00000379806CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3CDSENST00000474617ENST00000422285CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-intronENST00000474617ENST00000379805CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-5UTRENST00000474617ENST00000379804CCM2chr7

45039962

+PDHA1chrX

19375769

+
intron-3UTRENST00000474617ENST00000478795CCM2chr7

45039962

+PDHA1chrX

19375769

+
3UTR-3CDSENST00000461377ENST00000545074CCM2chr7

45039456

+PDHA1chrX

19375770

+
3UTR-3CDSENST00000461377ENST00000540249CCM2chr7

45039456

+PDHA1chrX

19375770

+
3UTR-3CDSENST00000461377ENST00000379806CCM2chr7

45039456

+PDHA1chrX

19375770

+
3UTR-3CDSENST00000461377ENST00000422285CCM2chr7

45039456

+PDHA1chrX

19375770

+
3UTR-intronENST00000461377ENST00000379805CCM2chr7

45039456

+PDHA1chrX

19375770

+
3UTR-5UTRENST00000461377ENST00000379804CCM2chr7

45039456

+PDHA1chrX

19375770

+
3UTR-3UTRENST00000461377ENST00000478795CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000258781ENST00000545074CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000258781ENST00000540249CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000258781ENST00000379806CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000258781ENST00000422285CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-intronENST00000258781ENST00000379805CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-5UTRENST00000258781ENST00000379804CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3UTRENST00000258781ENST00000478795CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000544363ENST00000545074CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000544363ENST00000540249CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000544363ENST00000379806CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000544363ENST00000422285CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-intronENST00000544363ENST00000379805CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-5UTRENST00000544363ENST00000379804CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3UTRENST00000544363ENST00000478795CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000541586ENST00000545074CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000541586ENST00000540249CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000541586ENST00000379806CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000541586ENST00000422285CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-intronENST00000541586ENST00000379805CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-5UTRENST00000541586ENST00000379804CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3UTRENST00000541586ENST00000478795CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000475551ENST00000545074CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000475551ENST00000540249CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000475551ENST00000379806CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000475551ENST00000422285CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-intronENST00000475551ENST00000379805CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-5UTRENST00000475551ENST00000379804CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3UTRENST00000475551ENST00000478795CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000381112ENST00000545074CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000381112ENST00000540249CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000381112ENST00000379806CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000381112ENST00000422285CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-intronENST00000381112ENST00000379805CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-5UTRENST00000381112ENST00000379804CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3UTRENST00000381112ENST00000478795CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000474617ENST00000545074CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000474617ENST00000540249CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000474617ENST00000379806CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3CDSENST00000474617ENST00000422285CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-intronENST00000474617ENST00000379805CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-5UTRENST00000474617ENST00000379804CCM2chr7

45039456

+PDHA1chrX

19375770

+
intron-3UTRENST00000474617ENST00000478795CCM2chr7

45039456

+PDHA1chrX

19375770

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000258781CCM2chr745039962+ENST00000545074PDHA1chrX19375770+257317989520143
ENST00000258781CCM2chr745039962+ENST00000540249PDHA1chrX19375770+257317989520143
ENST00000258781CCM2chr745039962+ENST00000379806PDHA1chrX19375770+257317989520143
ENST00000258781CCM2chr745039962+ENST00000422285PDHA1chrX19375770+255317989520143
ENST00000544363CCM2chr745039962+ENST00000545074PDHA1chrX19375770+257017686517143
ENST00000544363CCM2chr745039962+ENST00000540249PDHA1chrX19375770+257017686517143
ENST00000544363CCM2chr745039962+ENST00000379806PDHA1chrX19375770+257017686517143
ENST00000544363CCM2chr745039962+ENST00000422285PDHA1chrX19375770+255017686517143
ENST00000541586CCM2chr745039962+ENST00000545074PDHA1chrX19375770+257017686517143
ENST00000541586CCM2chr745039962+ENST00000540249PDHA1chrX19375770+257017686517143
ENST00000541586CCM2chr745039962+ENST00000379806PDHA1chrX19375770+257017686517143
ENST00000541586CCM2chr745039962+ENST00000422285PDHA1chrX19375770+255017686517143
ENST00000258781CCM2chr745039962+ENST00000545074PDHA1chrX19375769+257317989520143
ENST00000258781CCM2chr745039962+ENST00000540249PDHA1chrX19375769+257317989520143
ENST00000258781CCM2chr745039962+ENST00000379806PDHA1chrX19375769+257317989520143
ENST00000258781CCM2chr745039962+ENST00000422285PDHA1chrX19375769+255317989520143
ENST00000544363CCM2chr745039962+ENST00000545074PDHA1chrX19375769+257017686517143
ENST00000544363CCM2chr745039962+ENST00000540249PDHA1chrX19375769+257017686517143
ENST00000544363CCM2chr745039962+ENST00000379806PDHA1chrX19375769+257017686517143
ENST00000544363CCM2chr745039962+ENST00000422285PDHA1chrX19375769+255017686517143
ENST00000541586CCM2chr745039962+ENST00000545074PDHA1chrX19375769+257017686517143
ENST00000541586CCM2chr745039962+ENST00000540249PDHA1chrX19375769+257017686517143
ENST00000541586CCM2chr745039962+ENST00000379806PDHA1chrX19375769+257017686517143
ENST00000541586CCM2chr745039962+ENST00000422285PDHA1chrX19375769+255017686517143

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258781ENST00000545074CCM2chr745039962+PDHA1chrX19375770+0.0089231710.9910768
ENST00000258781ENST00000540249CCM2chr745039962+PDHA1chrX19375770+0.0089231710.9910768
ENST00000258781ENST00000379806CCM2chr745039962+PDHA1chrX19375770+0.0089231710.9910768
ENST00000258781ENST00000422285CCM2chr745039962+PDHA1chrX19375770+0.0084035630.9915964
ENST00000544363ENST00000545074CCM2chr745039962+PDHA1chrX19375770+0.0057547960.99424523
ENST00000544363ENST00000540249CCM2chr745039962+PDHA1chrX19375770+0.0057547960.99424523
ENST00000544363ENST00000379806CCM2chr745039962+PDHA1chrX19375770+0.0057547960.99424523
ENST00000544363ENST00000422285CCM2chr745039962+PDHA1chrX19375770+0.0054306640.99456936
ENST00000541586ENST00000545074CCM2chr745039962+PDHA1chrX19375770+0.0057547960.99424523
ENST00000541586ENST00000540249CCM2chr745039962+PDHA1chrX19375770+0.0057547960.99424523
ENST00000541586ENST00000379806CCM2chr745039962+PDHA1chrX19375770+0.0057547960.99424523
ENST00000541586ENST00000422285CCM2chr745039962+PDHA1chrX19375770+0.0054306640.99456936
ENST00000258781ENST00000545074CCM2chr745039962+PDHA1chrX19375769+0.0089231710.9910768
ENST00000258781ENST00000540249CCM2chr745039962+PDHA1chrX19375769+0.0089231710.9910768
ENST00000258781ENST00000379806CCM2chr745039962+PDHA1chrX19375769+0.0089231710.9910768
ENST00000258781ENST00000422285CCM2chr745039962+PDHA1chrX19375769+0.0084035630.9915964
ENST00000544363ENST00000545074CCM2chr745039962+PDHA1chrX19375769+0.0057547960.99424523
ENST00000544363ENST00000540249CCM2chr745039962+PDHA1chrX19375769+0.0057547960.99424523
ENST00000544363ENST00000379806CCM2chr745039962+PDHA1chrX19375769+0.0057547960.99424523
ENST00000544363ENST00000422285CCM2chr745039962+PDHA1chrX19375769+0.0054306640.99456936
ENST00000541586ENST00000545074CCM2chr745039962+PDHA1chrX19375769+0.0057547960.99424523
ENST00000541586ENST00000540249CCM2chr745039962+PDHA1chrX19375769+0.0057547960.99424523
ENST00000541586ENST00000379806CCM2chr745039962+PDHA1chrX19375769+0.0057547960.99424523
ENST00000541586ENST00000422285CCM2chr745039962+PDHA1chrX19375769+0.0054306640.99456936

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Fusion Genomic Features for CCM2-PDHA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CCM2chr745039456+PDHA1chrX19375769+7.52E-060.9999925
CCM2chr745039962+PDHA1chrX19375769+1.01E-081
CCM2chr745039962+PDHA1chrX19375769+1.01E-081
CCM2chr745039456+PDHA1chrX19375769+7.52E-060.9999925
CCM2chr745039962+PDHA1chrX19375769+1.01E-081
CCM2chr745039962+PDHA1chrX19375769+1.01E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCM2-PDHA1


check button Go to

FGviewer for the breakpoints of chr7:45039962-chrX:19375770

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCM2

Q9BSQ5

.
FUNCTION: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCM2chr7:45039962chrX:19375769ENST00000258781+11059_24810.0445.0DomainPID
HgeneCCM2chr7:45039962chrX:19375769ENST00000381112+11059_2480466.0DomainPID
HgeneCCM2chr7:45039962chrX:19375769ENST00000541586+1959_24810.0387.0DomainPID
HgeneCCM2chr7:45039962chrX:19375769ENST00000544363+1859_24810.0354.0DomainPID
HgeneCCM2chr7:45039962chrX:19375770ENST00000258781+11059_24810.0445.0DomainPID
HgeneCCM2chr7:45039962chrX:19375770ENST00000381112+11059_2480466.0DomainPID
HgeneCCM2chr7:45039962chrX:19375770ENST00000541586+1959_24810.0387.0DomainPID
HgeneCCM2chr7:45039962chrX:19375770ENST00000544363+1859_24810.0354.0DomainPID
HgeneCCM2chr7:45039962chrX:19375769ENST00000258781+110283_37610.0445.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45039962chrX:19375769ENST00000381112+110283_3760466.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45039962chrX:19375769ENST00000541586+19283_37610.0387.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45039962chrX:19375769ENST00000544363+18283_37610.0354.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45039962chrX:19375770ENST00000258781+110283_37610.0445.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45039962chrX:19375770ENST00000381112+110283_3760466.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45039962chrX:19375770ENST00000541586+19283_37610.0387.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45039962chrX:19375770ENST00000544363+18283_37610.0354.0RegionNote=Harmonin homology domain


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Fusion Gene Sequence for CCM2-PDHA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000258781_ENST00000545074_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(transcript)=2573nt_BP=179nt
GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC
TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGG
GGCCCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTC
AGGAAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAA
TTGATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACA
TCTACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGT
TATACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAA
CTTCCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGA
TTATTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCC
CAGCCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTG
CAGCCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAA
TCATTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTC
ATATCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCT
TCCATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTG
CCCAGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCA
TAGCTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATA
AATAACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACA
CAGCGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAA
GCCTTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAAC
AAACACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACAT
TCTCCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAA
ATGACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCC
CAGCCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCAC
CTTGGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACA
CATAAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAG
AATATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAA
TTTCTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGC
CCGTAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAAC

>In-frame_ENST00000258781_ENST00000545074_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(amino acids)=143AA_start in transcript=89_stop in transcript=520
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000258781_ENST00000540249_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(transcript)=2573nt_BP=179nt
GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC
TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGG
GGCCCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTC
AGGAAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAA
TTGATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACA
TCTACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGT
TATACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAA
CTTCCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGA
TTATTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCC
CAGCCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTG
CAGCCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAA
TCATTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTC
ATATCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCT
TCCATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTG
CCCAGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCA
TAGCTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATA
AATAACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACA
CAGCGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAA
GCCTTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAAC
AAACACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACAT
TCTCCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAA
ATGACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCC
CAGCCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCAC
CTTGGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACA
CATAAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAG
AATATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAA
TTTCTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGC
CCGTAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAAC

>In-frame_ENST00000258781_ENST00000540249_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(amino acids)=143AA_start in transcript=89_stop in transcript=520
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000258781_ENST00000379806_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(transcript)=2573nt_BP=179nt
GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC
TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGG
GGCCCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTC
AGGAAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAA
TTGATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACA
TCTACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGT
TATACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAA
CTTCCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGA
TTATTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCC
CAGCCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTG
CAGCCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAA
TCATTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTC
ATATCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCT
TCCATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTG
CCCAGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCA
TAGCTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATA
AATAACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACA
CAGCGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAA
GCCTTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAAC
AAACACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACAT
TCTCCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAA
ATGACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCC
CAGCCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCAC
CTTGGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACA
CATAAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAG
AATATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAA
TTTCTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGC
CCGTAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAAC

>In-frame_ENST00000258781_ENST00000379806_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(amino acids)=143AA_start in transcript=89_stop in transcript=520
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000258781_ENST00000422285_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(transcript)=2553nt_BP=179nt
GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC
TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGG
GGCCCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTC
AGGAAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAA
TTGATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACA
TCTACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGT
TATACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAA
CTTCCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGA
TTATTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCC
CAGCCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTG
CAGCCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAA
TCATTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTC
ATATCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCT
TCCATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTG
CCCAGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCA
TAGCTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATA
AATAACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACA
CAGCGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAA
GCCTTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAAC
AAACACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACAT
TCTCCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAA
ATGACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCC
CAGCCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCAC
CTTGGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACA
CATAAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAG
AATATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAA
TTTCTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGC
CCGTAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAAC

>In-frame_ENST00000258781_ENST00000422285_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(amino acids)=143AA_start in transcript=89_stop in transcript=520
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000544363_ENST00000545074_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(transcript)=2570nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000544363_ENST00000545074_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000544363_ENST00000540249_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(transcript)=2570nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000544363_ENST00000540249_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000544363_ENST00000379806_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(transcript)=2570nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000544363_ENST00000379806_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000544363_ENST00000422285_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(transcript)=2550nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000544363_ENST00000422285_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000541586_ENST00000545074_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(transcript)=2570nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000541586_ENST00000545074_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000541586_ENST00000540249_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(transcript)=2570nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000541586_ENST00000540249_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000541586_ENST00000379806_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(transcript)=2570nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000541586_ENST00000379806_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000541586_ENST00000422285_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(transcript)=2550nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000541586_ENST00000422285_TCGA-A7-A56D-01A_CCM2_chr7_45039962_+_PDHA1_chrX_19375770_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000258781_ENST00000545074_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(transcript)=2573nt_BP=179nt
GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC
TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGG
GGCCCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTC
AGGAAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAA
TTGATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACA
TCTACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGT
TATACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAA
CTTCCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGA
TTATTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCC
CAGCCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTG
CAGCCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAA
TCATTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTC
ATATCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCT
TCCATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTG
CCCAGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCA
TAGCTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATA
AATAACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACA
CAGCGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAA
GCCTTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAAC
AAACACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACAT
TCTCCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAA
ATGACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCC
CAGCCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCAC
CTTGGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACA
CATAAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAG
AATATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAA
TTTCTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGC
CCGTAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAAC

>In-frame_ENST00000258781_ENST00000545074_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(amino acids)=143AA_start in transcript=89_stop in transcript=520
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000258781_ENST00000540249_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(transcript)=2573nt_BP=179nt
GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC
TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGG
GGCCCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTC
AGGAAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAA
TTGATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACA
TCTACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGT
TATACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAA
CTTCCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGA
TTATTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCC
CAGCCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTG
CAGCCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAA
TCATTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTC
ATATCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCT
TCCATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTG
CCCAGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCA
TAGCTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATA
AATAACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACA
CAGCGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAA
GCCTTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAAC
AAACACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACAT
TCTCCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAA
ATGACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCC
CAGCCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCAC
CTTGGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACA
CATAAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAG
AATATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAA
TTTCTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGC
CCGTAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAAC

>In-frame_ENST00000258781_ENST00000540249_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(amino acids)=143AA_start in transcript=89_stop in transcript=520
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000258781_ENST00000379806_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(transcript)=2573nt_BP=179nt
GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC
TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGG
GGCCCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTC
AGGAAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAA
TTGATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACA
TCTACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGT
TATACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAA
CTTCCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGA
TTATTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCC
CAGCCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTG
CAGCCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAA
TCATTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTC
ATATCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCT
TCCATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTG
CCCAGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCA
TAGCTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATA
AATAACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACA
CAGCGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAA
GCCTTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAAC
AAACACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACAT
TCTCCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAA
ATGACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCC
CAGCCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCAC
CTTGGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACA
CATAAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAG
AATATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAA
TTTCTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGC
CCGTAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAAC

>In-frame_ENST00000258781_ENST00000379806_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(amino acids)=143AA_start in transcript=89_stop in transcript=520
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000258781_ENST00000422285_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(transcript)=2553nt_BP=179nt
GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC
TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGG
GGCCCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTC
AGGAAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAA
TTGATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACA
TCTACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGT
TATACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAA
CTTCCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGA
TTATTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCC
CAGCCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTG
CAGCCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAA
TCATTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTC
ATATCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCT
TCCATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTG
CCCAGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCA
TAGCTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATA
AATAACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACA
CAGCGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAA
GCCTTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAAC
AAACACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACAT
TCTCCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAA
ATGACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCC
CAGCCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCAC
CTTGGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACA
CATAAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAG
AATATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAA
TTTCTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGC
CCGTAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAAC

>In-frame_ENST00000258781_ENST00000422285_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(amino acids)=143AA_start in transcript=89_stop in transcript=520
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000544363_ENST00000545074_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(transcript)=2570nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000544363_ENST00000545074_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000544363_ENST00000540249_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(transcript)=2570nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000544363_ENST00000540249_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000544363_ENST00000379806_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(transcript)=2570nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000544363_ENST00000379806_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000544363_ENST00000422285_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(transcript)=2550nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000544363_ENST00000422285_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000541586_ENST00000545074_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(transcript)=2570nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000541586_ENST00000545074_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000541586_ENST00000540249_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(transcript)=2570nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000541586_ENST00000540249_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000541586_ENST00000379806_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(transcript)=2570nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000541586_ENST00000379806_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------
>In-frame_ENST00000541586_ENST00000422285_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(transcript)=2550nt_BP=176nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGGGGC
CCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACCCTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGG
AAGTAAGAAGTAAGAGTGACCCTATTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGGAAATTG
ATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATCCTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCT
ACTCCAGCGACCCACCTTTTGAAGTTCGTGGTGCCAATCAGTGGATCAAGTTTAAGTCAGTCAGTTAAGGGGAGGAGAAGGAGAGGTTAT
ACCTTCAGGGGGCTACCAGACAGTGTTCTCAACTTGGTTAAGGAGGAAGAAAACCCAGTCAATGAAATTCAATGAAATTCTTGGAAACTT
CCATTAAGTGTGTAGATTGAGCAGGTAGTAATTGCATGCAGTTTGTACATTAGTGCATTAAAAGATGAATTATTGAGTGCTTAAAGATTA
TTTTTGACTTAAAATAGTATACTTTGAACAAATACTCTAATTATGAAAAGGAAGAACAATTCCTTGTATGCCTGTTTCCCCTGCCCCCAG
CCACCTTTTTGGGAGGAGACCATTATGGCGGGGCCCCTCACAGCATTCTACCAACCATAGCACCCACCCCGAGCAGCGCTGGTGCTGCAG
CCTGTTCGCGCTGACCATTTCTCTACAAGATACAATATTTATTATCAGGCAAGAGGACAGTTCCATTTTAAAATAAGACTTTTGTAATCA
TTCCAATTTTGTAATCATTTCAAAGGCCACATAACTTAGTTTTCTCTACTTACACATTCAGTATAAATATGAAGCTATTTTCTGTTCATA
TCAAACATTAACTACAAGGCACATTCGTATCAGTTTTGTGTTTCTCAAATTGAAGTACCATACCAGTTCTGAGGCAGTGTCCCAGCTTCC
ATGTTTGTTAAATACCCCTTGTTTGTTTCACCATTCCAGCAAGTGCTGAAGGGTGTACTTTTTTTGAGACAGGGTCGGGCTCTGTTGCCC
AGGCTGGAGTGCAGTGGTGTGATCATGGCTCACTGCAGCCTCCACACCTCCTGGGCTCAAGCAATCCTCCCACCTCAGCCTCCTGCATAG
CTGGGACTACAAGTGAATTTCCTAATATTCCGGGAGGTCAAAACCAAGGCTCACTGTTTTCACAATACACACAGTTCTATGTTTATAAAT
AACAGGTTTCAAAAGAAACTCAGGACAGTATTTAAAACAAGTTCTTAAACTATTAATTGAACAATGGCATTTTTAAATATGTAAACACAG
CGGAATTCGTGTATACACTAACAGAAGCTTTAACAAAACATGTAGCGTGGTGGGACACTCTGCCACAGCTTAGCTGATTGGTATCAAGCC
TTGTCTTTGGTTTCTGAGGCCTCCTGAGCCCTTCTGTACTGGGAGACCGCACTCCAGAGTCTGCAGAGGAGACCACCCCTGGGAAACAAA
CACAGCTGTCTTCAGAGTCAGTGCTTCAAGCCAACAGAGCTTAAAACTGCAGTCCCTAATTTAAAAACCTAATGAAAATAAAAACATTCT
CCTCACATATGGAGGTGACGCTCGTGTCCCAGCAGTAGTAGGACATGGCCTTAGAGGTACGTACCTGCAGAGAGCTGGCTATTTCAAATG
ACTCGGGAACAAGAAGGCAGGCTGCAGTTTAAAGAAGGGGGTGGGTCCAGCGTGCAGGCACGCTTGCCATGTGCCTCCACCCACTCCCAG
CCAGGCATTAATGGCAGGAGATTGGCCAGCTCTTCTCTGTCACATTCCTATTTCTGACTTCTGCCTGGCTTTCAGTTTCTGCCCCACCTT
GGCTTTTTCCCAGCTTGAACCTAATAGAACTCCAGAGTTTGGGGGGAGGCCCAGCCCTTTGTTTTCTGCTCTTGAAGCATATTCACACAT
AAAAAGTTGTATTCTCTTATACAAACTGTTTTGAGGCTCTTACCGTAGTCGAAGGTATCTTAGATCTTCCTTAGTGATCTCATTAAGAAT
ATCCGAAAGTGTATAACCCTCTTCAACAATCTGAAACAAAGATCAGATCCTTAAGAGCTGAGCAGCTGTGTAACAACAGCATAAGAATTT
CTTTGTTGTAAATTTACCTTTTCAATTGTCTTTGCATCAGCTCCTTGCAGCCGCAACCAGTCTATAAGCTCTTTATCTGTTCTCTGCCCG
TAGGGGCCTGCTGGGTTCTCTGTAATACCTGTAACGATTGGCAATTTGTTATATATTAGTCTAACCATAAAACTCTTCAAAAGTAACCAG

>In-frame_ENST00000541586_ENST00000422285_TCGA-A7-A56D_CCM2_chr7_45039962_+_PDHA1_chrX_19375769_length(amino acids)=143AA_start in transcript=86_stop in transcript=517
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCM2-PDHA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCM2-PDHA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCM2-PDHA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCM2C1864041CEREBRAL CAVERNOUS MALFORMATIONS 23CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCCM2C2919945Cavernous Hemangioma of Brain2CTD_human;GENOMICS_ENGLAND
HgeneCCM2C0752160Hemangioma, Cavernous, Central Nervous System1CTD_human
HgeneCCM2C0752161Cavernous Hemangioma, Extracerebral1CTD_human
HgeneCCM2C0752164Cavernous Hemangioma, Intracerebral1CTD_human
HgeneCCM2C1140710Cerebral Cavernous Hemangioma1CTD_human
HgeneCCM2C1956260Cavernous Angioma, Central Nervous System1CTD_human
HgeneCCM2C4747394CAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION 11GENOMICS_ENGLAND
TgenePDHA1C1839413Pyruvate Dehydrogenase E1 Alpha Deficiency24GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgenePDHA1C0023264Leigh Disease8CLINGEN
TgenePDHA1C1838951LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY8CLINGEN
TgenePDHA1C1850597Leigh Syndrome Due To Mitochondrial Complex II Deficiency8CLINGEN
TgenePDHA1C1850598Leigh Syndrome due to Mitochondrial Complex III Deficiency8CLINGEN
TgenePDHA1C1850599Leigh Syndrome due to Mitochondrial Complex IV Deficiency8CLINGEN
TgenePDHA1C1850600Leigh Syndrome due to Mitochondrial Complex V Deficiency8CLINGEN
TgenePDHA1C2931891Necrotizing encephalopathy, infantile subacute, of Leigh8CLINGEN
TgenePDHA1C0034345Pyruvate Dehydrogenase Complex Deficiency Disease4CTD_human;ORPHANET
TgenePDHA1C0033578Prostatic Neoplasms2CTD_human
TgenePDHA1C0376358Malignant neoplasm of prostate2CTD_human
TgenePDHA1C0001125Acidosis, Lactic1CTD_human
TgenePDHA1C0024623Malignant neoplasm of stomach1CTD_human
TgenePDHA1C0029408Degenerative polyarthritis1CTD_human
TgenePDHA1C0034350Pyruvate Metabolism, Inborn Errors1CTD_human
TgenePDHA1C0038356Stomach Neoplasms1CTD_human
TgenePDHA1C0086743Osteoarthrosis Deformans1CTD_human
TgenePDHA1C0151744Myocardial Ischemia1CTD_human
TgenePDHA1C0235874Disease Exacerbation1CTD_human
TgenePDHA1C0751595Juvenile Pyruvate Dehydrogenase Complex Deficiency Disease1CTD_human
TgenePDHA1C0751596Pyruvate Dehydrogenase Complex Deficiency Disease, Neonatal1CTD_human
TgenePDHA1C0751597Ataxia with Lactic Acidosis, Type I1CTD_human
TgenePDHA1C1708349Hereditary Diffuse Gastric Cancer1CTD_human