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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCM2-PPIA (FusionGDB2 ID:14104)

Fusion Gene Summary for CCM2-PPIA

check button Fusion gene summary
Fusion gene informationFusion gene name: CCM2-PPIA
Fusion gene ID: 14104
HgeneTgene
Gene symbol

CCM2

PPIA

Gene ID

83605

5478

Gene nameCCM2 scaffold proteinpeptidylprolyl isomerase A
SynonymsC7orf22|OSM|PP10187CYPA|CYPH|HEL-S-69p
Cytomap

7p13

7p13

Type of geneprotein-codingprotein-coding
Descriptioncerebral cavernous malformations 2 proteinCCM2 scaffolding proteincerebral cavernous malformation 2malcaverninosmosensing scaffold for MEKK3peptidyl-prolyl cis-trans isomerase APPIase AT cell cyclophilincyclosporin A-binding proteinepididymis secretory sperm binding protein Li 69ppeptidylprolyl isomerase A (cyclophilin A)rotamase A
Modification date2020031320200329
UniProtAcc

Q9BSQ5

.
Ensembl transtripts involved in fusion geneENST00000461377, ENST00000258781, 
ENST00000544363, ENST00000541586, 
ENST00000475551, ENST00000381112, 
ENST00000474617, 		ENST00000451562, 
ENST00000468812, ENST00000489459, 
ENST00000355968, ENST00000480603, 
Fusion gene scores* DoF score9 X 5 X 6=2707 X 6 X 2=84
# samples 128
** MAII scorelog2(12/270*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/84*10)=-0.070389327891398
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCM2 [Title/Abstract] AND PPIA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCM2(45078025)-PPIA(44838846), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPIA

GO:0000413

protein peptidyl-prolyl isomerization

14993672|20676357


check buttonFusion gene breakpoints across CCM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PPIA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A26G-01ACCM2chr7

45078025

+PPIAchr7

44838846

+
ChimerDB4BRCATCGA-AR-A24O-01ACCM2chr7

45078025

+PPIAchr7

44838846

+
ChimerDB4BRCATCGA-A7-A26GCCM2chr7

45078025

+PPIAchr7

44838845

+
ChimerDB4BRCATCGA-A7-A26G-01ACCM2chr7

45078025

+PPIAchr7

44838846

+


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Fusion Gene ORF analysis for CCM2-PPIA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000461377ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838846

+
3UTR-3CDSENST00000461377ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838846

+
3UTR-5UTRENST00000461377ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838846

+
3UTR-5UTRENST00000461377ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838846

+
3UTR-3UTRENST00000461377ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838846

+
In-frameENST00000258781ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838846

+
In-frameENST00000258781ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-5UTRENST00000258781ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-5UTRENST00000258781ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-3UTRENST00000258781ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838846

+
In-frameENST00000544363ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838846

+
In-frameENST00000544363ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-5UTRENST00000544363ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-5UTRENST00000544363ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-3UTRENST00000544363ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838846

+
intron-3CDSENST00000541586ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838846

+
intron-3CDSENST00000541586ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838846

+
intron-5UTRENST00000541586ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838846

+
intron-5UTRENST00000541586ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838846

+
intron-3UTRENST00000541586ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838846

+
In-frameENST00000475551ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838846

+
In-frameENST00000475551ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-5UTRENST00000475551ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-5UTRENST00000475551ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-3UTRENST00000475551ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838846

+
In-frameENST00000381112ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838846

+
In-frameENST00000381112ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-5UTRENST00000381112ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-5UTRENST00000381112ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-3UTRENST00000381112ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838846

+
In-frameENST00000474617ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838846

+
In-frameENST00000474617ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-5UTRENST00000474617ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-5UTRENST00000474617ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838846

+
5CDS-3UTRENST00000474617ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838846

+
3UTR-3CDSENST00000461377ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838845

+
3UTR-3CDSENST00000461377ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838845

+
3UTR-5UTRENST00000461377ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838845

+
3UTR-5UTRENST00000461377ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838845

+
3UTR-3UTRENST00000461377ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838845

+
In-frameENST00000258781ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838845

+
In-frameENST00000258781ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-5UTRENST00000258781ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-5UTRENST00000258781ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-3UTRENST00000258781ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838845

+
In-frameENST00000544363ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838845

+
In-frameENST00000544363ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-5UTRENST00000544363ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-5UTRENST00000544363ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-3UTRENST00000544363ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838845

+
intron-3CDSENST00000541586ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838845

+
intron-3CDSENST00000541586ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838845

+
intron-5UTRENST00000541586ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838845

+
intron-5UTRENST00000541586ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838845

+
intron-3UTRENST00000541586ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838845

+
In-frameENST00000475551ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838845

+
In-frameENST00000475551ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-5UTRENST00000475551ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-5UTRENST00000475551ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-3UTRENST00000475551ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838845

+
In-frameENST00000381112ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838845

+
In-frameENST00000381112ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-5UTRENST00000381112ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-5UTRENST00000381112ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-3UTRENST00000381112ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838845

+
In-frameENST00000474617ENST00000451562CCM2chr7

45078025

+PPIAchr7

44838845

+
In-frameENST00000474617ENST00000468812CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-5UTRENST00000474617ENST00000489459CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-5UTRENST00000474617ENST00000355968CCM2chr7

45078025

+PPIAchr7

44838845

+
5CDS-3UTRENST00000474617ENST00000480603CCM2chr7

45078025

+PPIAchr7

44838845

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000258781CCM2chr745078025+ENST00000451562PPIAchr744838846+78335389649186
ENST00000258781CCM2chr745078025+ENST00000468812PPIAchr744838846+247735389781230
ENST00000544363CCM2chr745078025+ENST00000451562PPIAchr744838846+78035086646186
ENST00000544363CCM2chr745078025+ENST00000468812PPIAchr744838846+247435086778230
ENST00000475551CCM2chr745078025+ENST00000451562PPIAchr744838846+13769466791242187
ENST00000475551CCM2chr745078025+ENST00000468812PPIAchr744838846+30709466791374231
ENST00000381112CCM2chr745078025+ENST00000451562PPIAchr744838846+13769466791242187
ENST00000381112CCM2chr745078025+ENST00000468812PPIAchr744838846+30709466791374231
ENST00000474617CCM2chr745078025+ENST00000451562PPIAchr744838846+73030033596187
ENST00000474617CCM2chr745078025+ENST00000468812PPIAchr744838846+242430033728231
ENST00000258781CCM2chr745078025+ENST00000451562PPIAchr744838845+78335389649186
ENST00000258781CCM2chr745078025+ENST00000468812PPIAchr744838845+247735389781230
ENST00000544363CCM2chr745078025+ENST00000451562PPIAchr744838845+78035086646186
ENST00000544363CCM2chr745078025+ENST00000468812PPIAchr744838845+247435086778230
ENST00000475551CCM2chr745078025+ENST00000451562PPIAchr744838845+13769466791242187
ENST00000475551CCM2chr745078025+ENST00000468812PPIAchr744838845+30709466791374231
ENST00000381112CCM2chr745078025+ENST00000451562PPIAchr744838845+13769466791242187
ENST00000381112CCM2chr745078025+ENST00000468812PPIAchr744838845+30709466791374231
ENST00000474617CCM2chr745078025+ENST00000451562PPIAchr744838845+73030033596187
ENST00000474617CCM2chr745078025+ENST00000468812PPIAchr744838845+242430033728231

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258781ENST00000451562CCM2chr745078025+PPIAchr744838846+0.0043990180.99560094
ENST00000258781ENST00000468812CCM2chr745078025+PPIAchr744838846+0.0015180610.9984819
ENST00000544363ENST00000451562CCM2chr745078025+PPIAchr744838846+0.0043202760.99567974
ENST00000544363ENST00000468812CCM2chr745078025+PPIAchr744838846+0.0014443660.9985556
ENST00000475551ENST00000451562CCM2chr745078025+PPIAchr744838846+0.0025387580.9974612
ENST00000475551ENST00000468812CCM2chr745078025+PPIAchr744838846+0.0006488130.9993512
ENST00000381112ENST00000451562CCM2chr745078025+PPIAchr744838846+0.0025387580.9974612
ENST00000381112ENST00000468812CCM2chr745078025+PPIAchr744838846+0.0006488130.9993512
ENST00000474617ENST00000451562CCM2chr745078025+PPIAchr744838846+0.0023953290.9976046
ENST00000474617ENST00000468812CCM2chr745078025+PPIAchr744838846+0.0007536150.99924636
ENST00000258781ENST00000451562CCM2chr745078025+PPIAchr744838845+0.0043990180.99560094
ENST00000258781ENST00000468812CCM2chr745078025+PPIAchr744838845+0.0015180610.9984819
ENST00000544363ENST00000451562CCM2chr745078025+PPIAchr744838845+0.0043202760.99567974
ENST00000544363ENST00000468812CCM2chr745078025+PPIAchr744838845+0.0014443660.9985556
ENST00000475551ENST00000451562CCM2chr745078025+PPIAchr744838845+0.0025387580.9974612
ENST00000475551ENST00000468812CCM2chr745078025+PPIAchr744838845+0.0006488130.9993512
ENST00000381112ENST00000451562CCM2chr745078025+PPIAchr744838845+0.0025387580.9974612
ENST00000381112ENST00000468812CCM2chr745078025+PPIAchr744838845+0.0006488130.9993512
ENST00000474617ENST00000451562CCM2chr745078025+PPIAchr744838845+0.0023953290.9976046
ENST00000474617ENST00000468812CCM2chr745078025+PPIAchr744838845+0.0007536150.99924636

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Fusion Genomic Features for CCM2-PPIA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CCM2chr745078025+PPIAchr744838845+0.00492660.9950734
CCM2chr745078025+PPIAchr744838845+0.00492660.9950734
CCM2chr745078025+PPIAchr744838845+0.00492660.9950734
CCM2chr745078025+PPIAchr744838845+0.00492660.9950734

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCM2-PPIA


check button Go to

FGviewer for the breakpoints of chr7:45078025-chr7:44838846

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCM2

Q9BSQ5

.
FUNCTION: Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCM2chr7:45078025chr7:44838845ENST00000258781+21059_24868.0445.0DomainPID
HgeneCCM2chr7:45078025chr7:44838845ENST00000381112+21059_24889.0466.0DomainPID
HgeneCCM2chr7:45078025chr7:44838845ENST00000541586+1959_2480387.0DomainPID
HgeneCCM2chr7:45078025chr7:44838845ENST00000544363+2859_24868.0354.0DomainPID
HgeneCCM2chr7:45078025chr7:44838846ENST00000258781+21059_24868.0445.0DomainPID
HgeneCCM2chr7:45078025chr7:44838846ENST00000381112+21059_24889.0466.0DomainPID
HgeneCCM2chr7:45078025chr7:44838846ENST00000541586+1959_2480387.0DomainPID
HgeneCCM2chr7:45078025chr7:44838846ENST00000544363+2859_24868.0354.0DomainPID
HgeneCCM2chr7:45078025chr7:44838845ENST00000258781+210283_37668.0445.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45078025chr7:44838845ENST00000381112+210283_37689.0466.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45078025chr7:44838845ENST00000541586+19283_3760387.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45078025chr7:44838845ENST00000544363+28283_37668.0354.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45078025chr7:44838846ENST00000258781+210283_37668.0445.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45078025chr7:44838846ENST00000381112+210283_37689.0466.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45078025chr7:44838846ENST00000541586+19283_3760387.0RegionNote=Harmonin homology domain
HgeneCCM2chr7:45078025chr7:44838846ENST00000544363+28283_37668.0354.0RegionNote=Harmonin homology domain
TgenePPIAchr7:45078025chr7:44838845ENST00000468812057_16323.0166.0DomainPPIase cyclophilin-type
TgenePPIAchr7:45078025chr7:44838846ENST00000468812057_16323.0166.0DomainPPIase cyclophilin-type


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Fusion Gene Sequence for CCM2-PPIA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000258781_ENST00000451562_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(transcript)=783nt_BP=353nt
GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC
TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGC
CTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCC
CTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTG
CAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAA
TTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATG
AGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCA
CTGCCAAGACTGAGTGGTAAGGGTACAACATGGCACACTAACCACCTGACTAAATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTA

>In-frame_ENST00000258781_ENST00000451562_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(amino acids)=186AA_start in transcript=89_stop in transcript=649
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLF
ADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFIC

--------------------------------------------------------------
>In-frame_ENST00000258781_ENST00000468812_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(transcript)=2477nt_BP=353nt
GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC
TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGC
CTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCC
CTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTG
CAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAA
TTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATG
AGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCA
CTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTG
GGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCATTGCTGACTGTGGACAACTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACC
AGATCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCCACCCCATTTGCTCGCAGTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCT
TTGGGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTAGCTGGATTGCAGAGTTAAGTTTATGATTATGAAATAAAAACTAAATAACAATT
GTCCTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTATTTTAAGCAGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAATTCTAC
ACAGTACTTAGATTTTTTTTACTTTCCAGTCCCAGGAAGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCAT
GGTGGCTCACTGTCTGTAATGTATTACCTGAGGCAGAAGACCACCTGAGGGTAGGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCT
GTCTCTACAAAAAATAATTAGCCTGGCCTGGTGGTGCATGCCTAGTCCTAGCTGATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTA
GAGTGAGCTATTATCATGCCACTGTACAGCCTGGGTGTTCACAGATCTTGTGTCTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCA
GAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATGCATTTAGAGGTGTTCTTCAAGATGACTAATGTCAAAAATTGAGACATCTGTTG
CGGTTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTGGCGTGATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGT
GCCTCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTATAGATGGGGTTTCATCAT
TTTGACCAGGCTGGTCTCAAACTCTTGACCTCAGCTGATGCGCCTGCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGC
ACCCTACCTCATTTTCTGTAACAAAGCTAAGCTTGAACACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGT
TTATACATCTTAATTATGGTGGAATTCCTATGTAGAGTCTAAAAAGCCAGGTACTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAG
GCGCAGACTACCTGCAGTGAGGAGGTACTGCTTGTAGCATATAGAGCCTCTCCCTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAAC
CTGACCAATTTAAGCCATAAGATCTGGTCAAAGGGATACCCTTCCCACTAAGGACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGC
TGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAAAACCCCTTCTCTGCCCACCTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAA
GTTTGCCTATCCTAGAGGTGGCGGATTTGATCATTTGGTGTGTTGGGCAATTTTTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCA
CCACCACCACTTGTGCATCTCAGTCTTGTGTGTTGTCTGGTTACGTATTCCCTGGGTGATACCATTCAATGTCTTAATGTACTTGTGGCT

>In-frame_ENST00000258781_ENST00000468812_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(amino acids)=230AA_start in transcript=89_stop in transcript=781
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLF
ADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFIC

--------------------------------------------------------------
>In-frame_ENST00000544363_ENST00000451562_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(transcript)=780nt_BP=350nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGCCTG
GAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTC
TGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAG
ACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTA
TTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGA
ACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTG
CCAAGACTGAGTGGTAAGGGTACAACATGGCACACTAACCACCTGACTAAATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTACTT

>In-frame_ENST00000544363_ENST00000451562_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(amino acids)=186AA_start in transcript=86_stop in transcript=646
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLF
ADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFIC

--------------------------------------------------------------
>In-frame_ENST00000544363_ENST00000468812_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(transcript)=2474nt_BP=350nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGCCTG
GAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTC
TGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAG
ACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTA
TTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGA
ACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTG
CCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTGGGT
CCAGGAATGGCAAGACCAGCAAGAAGATCACCATTGCTGACTGTGGACAACTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACCAGA
TCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCCACCCCATTTGCTCGCAGTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCTTTG
GGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTAGCTGGATTGCAGAGTTAAGTTTATGATTATGAAATAAAAACTAAATAACAATTGTC
CTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTATTTTAAGCAGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAATTCTACACA
GTACTTAGATTTTTTTTACTTTCCAGTCCCAGGAAGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCATGGT
GGCTCACTGTCTGTAATGTATTACCTGAGGCAGAAGACCACCTGAGGGTAGGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCTGTC
TCTACAAAAAATAATTAGCCTGGCCTGGTGGTGCATGCCTAGTCCTAGCTGATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTAGAG
TGAGCTATTATCATGCCACTGTACAGCCTGGGTGTTCACAGATCTTGTGTCTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCAGAA
TTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATGCATTTAGAGGTGTTCTTCAAGATGACTAATGTCAAAAATTGAGACATCTGTTGCGG
TTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTGGCGTGATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGTGCC
TCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTT
GACCAGGCTGGTCTCAAACTCTTGACCTCAGCTGATGCGCCTGCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGCACC
CTACCTCATTTTCTGTAACAAAGCTAAGCTTGAACACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGTTTA
TACATCTTAATTATGGTGGAATTCCTATGTAGAGTCTAAAAAGCCAGGTACTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAGGCG
CAGACTACCTGCAGTGAGGAGGTACTGCTTGTAGCATATAGAGCCTCTCCCTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAACCTG
ACCAATTTAAGCCATAAGATCTGGTCAAAGGGATACCCTTCCCACTAAGGACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGCTGG
CAGTTAGATGTCAGGACAATCTAAGCTGAGAAAACCCCTTCTCTGCCCACCTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAAGTT
TGCCTATCCTAGAGGTGGCGGATTTGATCATTTGGTGTGTTGGGCAATTTTTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCACCA
CCACCACTTGTGCATCTCAGTCTTGTGTGTTGTCTGGTTACGTATTCCCTGGGTGATACCATTCAATGTCTTAATGTACTTGTGGCTCAG

>In-frame_ENST00000544363_ENST00000468812_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(amino acids)=230AA_start in transcript=86_stop in transcript=778
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLF
ADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFIC

--------------------------------------------------------------
>In-frame_ENST00000475551_ENST00000451562_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(transcript)=1376nt_BP=946nt
GAAGAAGTGAGCTTGGCCAGAGGCACGCTGTTTAATTTCAAAGTGCTGCTGACTCAAACTCATGAGTCCTGGAGGCAGGTAGAGGCACTT
GTAGGCTGAGGACCCGTAGAGCCCGGTGTGCCCTGCCCAAGCCCCACCTGGGAATGGAGTTATCTCTGTAAAGATCTTGCTGCCTTTGAG
CAAGCACTGCAAATGGGGTAACTGGAACAGCCTTGTCGCGTGTTTCCACCCTTCGTATGAGGCAGGTACCATGGGTCTTCACCAACAGCA
CGGCCTGTTGTCTCCAGGAAATGGTAGCCCCTCACAGTGCTTTCTGTCTGCTTGTTTAGCTTTGGCATTTGAATGTGCAGAATGGTGGAC
TTTGAAATTAATGTCCTTCTGTTGACTGCAGAATTTCTGCTGGAAATGCAGGGAGGCTGCTTGTGGGGTTCGCGTGCTGTGGGAAGTAGG
GAAAATGAGCTGGTTTACTTTGTGTCTTTTTGTGCATGCAGACTGTTTGGATTTTGCCAACAGTTTCTGGGTGCTGCCTGCTTTTTAAAC
TTTTAAAAAATTGTAAACAGCTTCAGTGGCTTTGCAGAAGGAAGCTGTGGTTTCTGGTCTTCCTGTTCAGTCATGTTTTTTTCAGAGGGA
GGGCTAACATCTGGCCATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTC
CAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAA
AGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGT
CGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGC
TCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCAC
ACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTT
GTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTAAGGGTACAACATGGCACA
CTAACCACCTGACTAAATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTACTTTTCTTCAACCTTTGCTTCCACAGACTTTTTCATC

>In-frame_ENST00000475551_ENST00000451562_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(amino acids)=187AA_start in transcript=679_stop in transcript=1242
MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL
FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI

--------------------------------------------------------------
>In-frame_ENST00000475551_ENST00000468812_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(transcript)=3070nt_BP=946nt
GAAGAAGTGAGCTTGGCCAGAGGCACGCTGTTTAATTTCAAAGTGCTGCTGACTCAAACTCATGAGTCCTGGAGGCAGGTAGAGGCACTT
GTAGGCTGAGGACCCGTAGAGCCCGGTGTGCCCTGCCCAAGCCCCACCTGGGAATGGAGTTATCTCTGTAAAGATCTTGCTGCCTTTGAG
CAAGCACTGCAAATGGGGTAACTGGAACAGCCTTGTCGCGTGTTTCCACCCTTCGTATGAGGCAGGTACCATGGGTCTTCACCAACAGCA
CGGCCTGTTGTCTCCAGGAAATGGTAGCCCCTCACAGTGCTTTCTGTCTGCTTGTTTAGCTTTGGCATTTGAATGTGCAGAATGGTGGAC
TTTGAAATTAATGTCCTTCTGTTGACTGCAGAATTTCTGCTGGAAATGCAGGGAGGCTGCTTGTGGGGTTCGCGTGCTGTGGGAAGTAGG
GAAAATGAGCTGGTTTACTTTGTGTCTTTTTGTGCATGCAGACTGTTTGGATTTTGCCAACAGTTTCTGGGTGCTGCCTGCTTTTTAAAC
TTTTAAAAAATTGTAAACAGCTTCAGTGGCTTTGCAGAAGGAAGCTGTGGTTTCTGGTCTTCCTGTTCAGTCATGTTTTTTTCAGAGGGA
GGGCTAACATCTGGCCATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTC
CAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAA
AGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGT
CGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGC
TCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCAC
ACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTT
GTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGT
GTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTGGGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCAT
TGCTGACTGTGGACAACTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACCAGATCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCC
ACCCCATTTGCTCGCAGTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCTTTGGGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTA
GCTGGATTGCAGAGTTAAGTTTATGATTATGAAATAAAAACTAAATAACAATTGTCCTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTA
TTTTAAGCAGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAATTCTACACAGTACTTAGATTTTTTTTACTTTCCAGTCCCAGGA
AGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCATGGTGGCTCACTGTCTGTAATGTATTACCTGAGGCAGA
AGACCACCTGAGGGTAGGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCTGTCTCTACAAAAAATAATTAGCCTGGCCTGGTGGTGC
ATGCCTAGTCCTAGCTGATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTAGAGTGAGCTATTATCATGCCACTGTACAGCCTGGGTG
TTCACAGATCTTGTGTCTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCAGAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATG
CATTTAGAGGTGTTCTTCAAGATGACTAATGTCAAAAATTGAGACATCTGTTGCGGTTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTG
GCGTGATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGTGCCTCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGT
GCCACCATGCCCAGCTAATTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTTGACCAGGCTGGTCTCAAACTCTTGACCTCAGCTG
ATGCGCCTGCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGCACCCTACCTCATTTTCTGTAACAAAGCTAAGCTTGAA
CACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGTTTATACATCTTAATTATGGTGGAATTCCTATGTAGAG
TCTAAAAAGCCAGGTACTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAGGCGCAGACTACCTGCAGTGAGGAGGTACTGCTTGTAG
CATATAGAGCCTCTCCCTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAACCTGACCAATTTAAGCCATAAGATCTGGTCAAAGGGAT
ACCCTTCCCACTAAGGACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGCTGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAAAA
CCCCTTCTCTGCCCACCTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAAGTTTGCCTATCCTAGAGGTGGCGGATTTGATCATTTG
GTGTGTTGGGCAATTTTTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCACCACCACCACTTGTGCATCTCAGTCTTGTGTGTTGTC
TGGTTACGTATTCCCTGGGTGATACCATTCAATGTCTTAATGTACTTGTGGCTCAGACCTGAGTGCAAGGTGGAAATAAACATCAAACAT

>In-frame_ENST00000475551_ENST00000468812_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(amino acids)=231AA_start in transcript=679_stop in transcript=1374
MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL
FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI

--------------------------------------------------------------
>In-frame_ENST00000381112_ENST00000451562_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(transcript)=1376nt_BP=946nt
GAAGAAGTGAGCTTGGCCAGAGGCACGCTGTTTAATTTCAAAGTGCTGCTGACTCAAACTCATGAGTCCTGGAGGCAGGTAGAGGCACTT
GTAGGCTGAGGACCCGTAGAGCCCGGTGTGCCCTGCCCAAGCCCCACCTGGGAATGGAGTTATCTCTGTAAAGATCTTGCTGCCTTTGAG
CAAGCACTGCAAATGGGGTAACTGGAACAGCCTTGTCGCGTGTTTCCACCCTTCGTATGAGGCAGGTACCATGGGTCTTCACCAACAGCA
CGGCCTGTTGTCTCCAGGAAATGGTAGCCCCTCACAGTGCTTTCTGTCTGCTTGTTTAGCTTTGGCATTTGAATGTGCAGAATGGTGGAC
TTTGAAATTAATGTCCTTCTGTTGACTGCAGAATTTCTGCTGGAAATGCAGGGAGGCTGCTTGTGGGGTTCGCGTGCTGTGGGAAGTAGG
GAAAATGAGCTGGTTTACTTTGTGTCTTTTTGTGCATGCAGACTGTTTGGATTTTGCCAACAGTTTCTGGGTGCTGCCTGCTTTTTAAAC
TTTTAAAAAATTGTAAACAGCTTCAGTGGCTTTGCAGAAGGAAGCTGTGGTTTCTGGTCTTCCTGTTCAGTCATGTTTTTTTCAGAGGGA
GGGCTAACATCTGGCCATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTC
CAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAA
AGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGT
CGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGC
TCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCAC
ACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTT
GTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTAAGGGTACAACATGGCACA
CTAACCACCTGACTAAATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTACTTTTCTTCAACCTTTGCTTCCACAGACTTTTTCATC

>In-frame_ENST00000381112_ENST00000451562_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(amino acids)=187AA_start in transcript=679_stop in transcript=1242
MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL
FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI

--------------------------------------------------------------
>In-frame_ENST00000381112_ENST00000468812_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(transcript)=3070nt_BP=946nt
GAAGAAGTGAGCTTGGCCAGAGGCACGCTGTTTAATTTCAAAGTGCTGCTGACTCAAACTCATGAGTCCTGGAGGCAGGTAGAGGCACTT
GTAGGCTGAGGACCCGTAGAGCCCGGTGTGCCCTGCCCAAGCCCCACCTGGGAATGGAGTTATCTCTGTAAAGATCTTGCTGCCTTTGAG
CAAGCACTGCAAATGGGGTAACTGGAACAGCCTTGTCGCGTGTTTCCACCCTTCGTATGAGGCAGGTACCATGGGTCTTCACCAACAGCA
CGGCCTGTTGTCTCCAGGAAATGGTAGCCCCTCACAGTGCTTTCTGTCTGCTTGTTTAGCTTTGGCATTTGAATGTGCAGAATGGTGGAC
TTTGAAATTAATGTCCTTCTGTTGACTGCAGAATTTCTGCTGGAAATGCAGGGAGGCTGCTTGTGGGGTTCGCGTGCTGTGGGAAGTAGG
GAAAATGAGCTGGTTTACTTTGTGTCTTTTTGTGCATGCAGACTGTTTGGATTTTGCCAACAGTTTCTGGGTGCTGCCTGCTTTTTAAAC
TTTTAAAAAATTGTAAACAGCTTCAGTGGCTTTGCAGAAGGAAGCTGTGGTTTCTGGTCTTCCTGTTCAGTCATGTTTTTTTCAGAGGGA
GGGCTAACATCTGGCCATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTC
CAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAA
AGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGT
CGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGC
TCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCAC
ACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTT
GTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGT
GTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTGGGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCAT
TGCTGACTGTGGACAACTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACCAGATCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCC
ACCCCATTTGCTCGCAGTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCTTTGGGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTA
GCTGGATTGCAGAGTTAAGTTTATGATTATGAAATAAAAACTAAATAACAATTGTCCTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTA
TTTTAAGCAGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAATTCTACACAGTACTTAGATTTTTTTTACTTTCCAGTCCCAGGA
AGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCATGGTGGCTCACTGTCTGTAATGTATTACCTGAGGCAGA
AGACCACCTGAGGGTAGGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCTGTCTCTACAAAAAATAATTAGCCTGGCCTGGTGGTGC
ATGCCTAGTCCTAGCTGATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTAGAGTGAGCTATTATCATGCCACTGTACAGCCTGGGTG
TTCACAGATCTTGTGTCTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCAGAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATG
CATTTAGAGGTGTTCTTCAAGATGACTAATGTCAAAAATTGAGACATCTGTTGCGGTTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTG
GCGTGATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGTGCCTCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGT
GCCACCATGCCCAGCTAATTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTTGACCAGGCTGGTCTCAAACTCTTGACCTCAGCTG
ATGCGCCTGCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGCACCCTACCTCATTTTCTGTAACAAAGCTAAGCTTGAA
CACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGTTTATACATCTTAATTATGGTGGAATTCCTATGTAGAG
TCTAAAAAGCCAGGTACTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAGGCGCAGACTACCTGCAGTGAGGAGGTACTGCTTGTAG
CATATAGAGCCTCTCCCTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAACCTGACCAATTTAAGCCATAAGATCTGGTCAAAGGGAT
ACCCTTCCCACTAAGGACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGCTGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAAAA
CCCCTTCTCTGCCCACCTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAAGTTTGCCTATCCTAGAGGTGGCGGATTTGATCATTTG
GTGTGTTGGGCAATTTTTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCACCACCACCACTTGTGCATCTCAGTCTTGTGTGTTGTC
TGGTTACGTATTCCCTGGGTGATACCATTCAATGTCTTAATGTACTTGTGGCTCAGACCTGAGTGCAAGGTGGAAATAAACATCAAACAT

>In-frame_ENST00000381112_ENST00000468812_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(amino acids)=231AA_start in transcript=679_stop in transcript=1374
MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL
FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI

--------------------------------------------------------------
>In-frame_ENST00000474617_ENST00000451562_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(transcript)=730nt_BP=300nt
ATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTCCAAAGAAATTCCTCAA
ACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGA
GATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTG
CTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAG
AAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACT
GGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCT
GGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTAAGGGTACAACATGGCACACTAACCACCTGACTAA
ATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTACTTTTCTTCAACCTTTGCTTCCACAGACTTTTTCATCCCTAAGATACTAGAAG

>In-frame_ENST00000474617_ENST00000451562_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(amino acids)=187AA_start in transcript=33_stop in transcript=596
MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL
FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI

--------------------------------------------------------------
>In-frame_ENST00000474617_ENST00000468812_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(transcript)=2424nt_BP=300nt
ATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTCCAAAGAAATTCCTCAA
ACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGA
GATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTG
CTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAG
AAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACT
GGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCT
GGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAA
GAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTGGGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCATTGCTGACTGTGGACAA
CTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACCAGATCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCCACCCCATTTGCTCGCA
GTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCTTTGGGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTAGCTGGATTGCAGAGTT
AAGTTTATGATTATGAAATAAAAACTAAATAACAATTGTCCTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTATTTTAAGCAGTAATGG
GTTACTTCTGAAACATCACTTGTTTGCTTAATTCTACACAGTACTTAGATTTTTTTTACTTTCCAGTCCCAGGAAGTGTCAATGTTTGTT
GAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCATGGTGGCTCACTGTCTGTAATGTATTACCTGAGGCAGAAGACCACCTGAGGGTA
GGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCTGTCTCTACAAAAAATAATTAGCCTGGCCTGGTGGTGCATGCCTAGTCCTAGCT
GATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTAGAGTGAGCTATTATCATGCCACTGTACAGCCTGGGTGTTCACAGATCTTGTGT
CTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCAGAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATGCATTTAGAGGTGTTCT
TCAAGATGACTAATGTCAAAAATTGAGACATCTGTTGCGGTTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTGGCGTGATCTCAGCTCA
CTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGTGCCTCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGTGCCACCATGCCCAGCT
AATTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTTGACCAGGCTGGTCTCAAACTCTTGACCTCAGCTGATGCGCCTGCCTTGGC
CTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGCACCCTACCTCATTTTCTGTAACAAAGCTAAGCTTGAACACTGTTGATGTTCTT
GAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGTTTATACATCTTAATTATGGTGGAATTCCTATGTAGAGTCTAAAAAGCCAGGTA
CTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAGGCGCAGACTACCTGCAGTGAGGAGGTACTGCTTGTAGCATATAGAGCCTCTCC
CTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAACCTGACCAATTTAAGCCATAAGATCTGGTCAAAGGGATACCCTTCCCACTAAGG
ACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGCTGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAAAACCCCTTCTCTGCCCAC
CTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAAGTTTGCCTATCCTAGAGGTGGCGGATTTGATCATTTGGTGTGTTGGGCAATTT
TTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCACCACCACCACTTGTGCATCTCAGTCTTGTGTGTTGTCTGGTTACGTATTCCCT

>In-frame_ENST00000474617_ENST00000468812_TCGA-A7-A26G-01A_CCM2_chr7_45078025_+_PPIA_chr7_44838846_length(amino acids)=231AA_start in transcript=33_stop in transcript=728
MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL
FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI

--------------------------------------------------------------
>In-frame_ENST00000258781_ENST00000451562_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(transcript)=783nt_BP=353nt
GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC
TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGC
CTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCC
CTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTG
CAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAA
TTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATG
AGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCA
CTGCCAAGACTGAGTGGTAAGGGTACAACATGGCACACTAACCACCTGACTAAATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTA

>In-frame_ENST00000258781_ENST00000451562_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(amino acids)=186AA_start in transcript=89_stop in transcript=649
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLF
ADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFIC

--------------------------------------------------------------
>In-frame_ENST00000258781_ENST00000468812_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(transcript)=2477nt_BP=353nt
GGGGCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGC
TGCTGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGC
CTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCC
CTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTG
CAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAA
TTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATG
AGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCA
CTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTG
GGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCATTGCTGACTGTGGACAACTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACC
AGATCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCCACCCCATTTGCTCGCAGTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCT
TTGGGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTAGCTGGATTGCAGAGTTAAGTTTATGATTATGAAATAAAAACTAAATAACAATT
GTCCTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTATTTTAAGCAGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAATTCTAC
ACAGTACTTAGATTTTTTTTACTTTCCAGTCCCAGGAAGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCAT
GGTGGCTCACTGTCTGTAATGTATTACCTGAGGCAGAAGACCACCTGAGGGTAGGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCT
GTCTCTACAAAAAATAATTAGCCTGGCCTGGTGGTGCATGCCTAGTCCTAGCTGATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTA
GAGTGAGCTATTATCATGCCACTGTACAGCCTGGGTGTTCACAGATCTTGTGTCTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCA
GAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATGCATTTAGAGGTGTTCTTCAAGATGACTAATGTCAAAAATTGAGACATCTGTTG
CGGTTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTGGCGTGATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGT
GCCTCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTATAGATGGGGTTTCATCAT
TTTGACCAGGCTGGTCTCAAACTCTTGACCTCAGCTGATGCGCCTGCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGC
ACCCTACCTCATTTTCTGTAACAAAGCTAAGCTTGAACACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGT
TTATACATCTTAATTATGGTGGAATTCCTATGTAGAGTCTAAAAAGCCAGGTACTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAG
GCGCAGACTACCTGCAGTGAGGAGGTACTGCTTGTAGCATATAGAGCCTCTCCCTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAAC
CTGACCAATTTAAGCCATAAGATCTGGTCAAAGGGATACCCTTCCCACTAAGGACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGC
TGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAAAACCCCTTCTCTGCCCACCTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAA
GTTTGCCTATCCTAGAGGTGGCGGATTTGATCATTTGGTGTGTTGGGCAATTTTTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCA
CCACCACCACTTGTGCATCTCAGTCTTGTGTGTTGTCTGGTTACGTATTCCCTGGGTGATACCATTCAATGTCTTAATGTACTTGTGGCT

>In-frame_ENST00000258781_ENST00000468812_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(amino acids)=230AA_start in transcript=89_stop in transcript=781
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLF
ADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFIC

--------------------------------------------------------------
>In-frame_ENST00000544363_ENST00000451562_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(transcript)=780nt_BP=350nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGCCTG
GAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTC
TGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAG
ACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTA
TTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGA
ACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTG
CCAAGACTGAGTGGTAAGGGTACAACATGGCACACTAACCACCTGACTAAATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTACTT

>In-frame_ENST00000544363_ENST00000451562_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(amino acids)=186AA_start in transcript=86_stop in transcript=646
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLF
ADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFIC

--------------------------------------------------------------
>In-frame_ENST00000544363_ENST00000468812_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(transcript)=2474nt_BP=350nt
GCGCGGCCGGGGCGGAGACTTCGGGCCCGGCTGGCGGGCGGCGCCGGGAGCGCGGGGGCGGCGGGCCCGGGTCGAGCATGTAGCGGCTGC
TGGCGGCGGGGCTCCCGGGGCGGGCCGGGCGGGCCGCGGGAGCCGCACGCGGCGATATGGAAGAGGAGGGCAAGAAGGGCAAGAAGCCTG
GAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTC
TGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAG
ACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTA
TTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGA
ACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTG
CCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTGGGT
CCAGGAATGGCAAGACCAGCAAGAAGATCACCATTGCTGACTGTGGACAACTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACCAGA
TCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCCACCCCATTTGCTCGCAGTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCTTTG
GGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTAGCTGGATTGCAGAGTTAAGTTTATGATTATGAAATAAAAACTAAATAACAATTGTC
CTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTATTTTAAGCAGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAATTCTACACA
GTACTTAGATTTTTTTTACTTTCCAGTCCCAGGAAGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCATGGT
GGCTCACTGTCTGTAATGTATTACCTGAGGCAGAAGACCACCTGAGGGTAGGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCTGTC
TCTACAAAAAATAATTAGCCTGGCCTGGTGGTGCATGCCTAGTCCTAGCTGATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTAGAG
TGAGCTATTATCATGCCACTGTACAGCCTGGGTGTTCACAGATCTTGTGTCTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCAGAA
TTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATGCATTTAGAGGTGTTCTTCAAGATGACTAATGTCAAAAATTGAGACATCTGTTGCGG
TTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTGGCGTGATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGTGCC
TCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGTGCCACCATGCCCAGCTAATTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTT
GACCAGGCTGGTCTCAAACTCTTGACCTCAGCTGATGCGCCTGCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGCACC
CTACCTCATTTTCTGTAACAAAGCTAAGCTTGAACACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGTTTA
TACATCTTAATTATGGTGGAATTCCTATGTAGAGTCTAAAAAGCCAGGTACTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAGGCG
CAGACTACCTGCAGTGAGGAGGTACTGCTTGTAGCATATAGAGCCTCTCCCTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAACCTG
ACCAATTTAAGCCATAAGATCTGGTCAAAGGGATACCCTTCCCACTAAGGACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGCTGG
CAGTTAGATGTCAGGACAATCTAAGCTGAGAAAACCCCTTCTCTGCCCACCTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAAGTT
TGCCTATCCTAGAGGTGGCGGATTTGATCATTTGGTGTGTTGGGCAATTTTTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCACCA
CCACCACTTGTGCATCTCAGTCTTGTGTGTTGTCTGGTTACGTATTCCCTGGGTGATACCATTCAATGTCTTAATGTACTTGTGGCTCAG

>In-frame_ENST00000544363_ENST00000468812_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(amino acids)=230AA_start in transcript=86_stop in transcript=778
MLAAGLPGRAGRAAGAARGDMEEEGKKGKKPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKLF
ADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFIC

--------------------------------------------------------------
>In-frame_ENST00000475551_ENST00000451562_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(transcript)=1376nt_BP=946nt
GAAGAAGTGAGCTTGGCCAGAGGCACGCTGTTTAATTTCAAAGTGCTGCTGACTCAAACTCATGAGTCCTGGAGGCAGGTAGAGGCACTT
GTAGGCTGAGGACCCGTAGAGCCCGGTGTGCCCTGCCCAAGCCCCACCTGGGAATGGAGTTATCTCTGTAAAGATCTTGCTGCCTTTGAG
CAAGCACTGCAAATGGGGTAACTGGAACAGCCTTGTCGCGTGTTTCCACCCTTCGTATGAGGCAGGTACCATGGGTCTTCACCAACAGCA
CGGCCTGTTGTCTCCAGGAAATGGTAGCCCCTCACAGTGCTTTCTGTCTGCTTGTTTAGCTTTGGCATTTGAATGTGCAGAATGGTGGAC
TTTGAAATTAATGTCCTTCTGTTGACTGCAGAATTTCTGCTGGAAATGCAGGGAGGCTGCTTGTGGGGTTCGCGTGCTGTGGGAAGTAGG
GAAAATGAGCTGGTTTACTTTGTGTCTTTTTGTGCATGCAGACTGTTTGGATTTTGCCAACAGTTTCTGGGTGCTGCCTGCTTTTTAAAC
TTTTAAAAAATTGTAAACAGCTTCAGTGGCTTTGCAGAAGGAAGCTGTGGTTTCTGGTCTTCCTGTTCAGTCATGTTTTTTTCAGAGGGA
GGGCTAACATCTGGCCATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTC
CAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAA
AGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGT
CGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGC
TCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCAC
ACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTT
GTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTAAGGGTACAACATGGCACA
CTAACCACCTGACTAAATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTACTTTTCTTCAACCTTTGCTTCCACAGACTTTTTCATC

>In-frame_ENST00000475551_ENST00000451562_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(amino acids)=187AA_start in transcript=679_stop in transcript=1242
MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL
FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI

--------------------------------------------------------------
>In-frame_ENST00000475551_ENST00000468812_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(transcript)=3070nt_BP=946nt
GAAGAAGTGAGCTTGGCCAGAGGCACGCTGTTTAATTTCAAAGTGCTGCTGACTCAAACTCATGAGTCCTGGAGGCAGGTAGAGGCACTT
GTAGGCTGAGGACCCGTAGAGCCCGGTGTGCCCTGCCCAAGCCCCACCTGGGAATGGAGTTATCTCTGTAAAGATCTTGCTGCCTTTGAG
CAAGCACTGCAAATGGGGTAACTGGAACAGCCTTGTCGCGTGTTTCCACCCTTCGTATGAGGCAGGTACCATGGGTCTTCACCAACAGCA
CGGCCTGTTGTCTCCAGGAAATGGTAGCCCCTCACAGTGCTTTCTGTCTGCTTGTTTAGCTTTGGCATTTGAATGTGCAGAATGGTGGAC
TTTGAAATTAATGTCCTTCTGTTGACTGCAGAATTTCTGCTGGAAATGCAGGGAGGCTGCTTGTGGGGTTCGCGTGCTGTGGGAAGTAGG
GAAAATGAGCTGGTTTACTTTGTGTCTTTTTGTGCATGCAGACTGTTTGGATTTTGCCAACAGTTTCTGGGTGCTGCCTGCTTTTTAAAC
TTTTAAAAAATTGTAAACAGCTTCAGTGGCTTTGCAGAAGGAAGCTGTGGTTTCTGGTCTTCCTGTTCAGTCATGTTTTTTTCAGAGGGA
GGGCTAACATCTGGCCATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTC
CAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAA
AGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGT
CGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGC
TCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCAC
ACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTT
GTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGT
GTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTGGGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCAT
TGCTGACTGTGGACAACTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACCAGATCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCC
ACCCCATTTGCTCGCAGTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCTTTGGGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTA
GCTGGATTGCAGAGTTAAGTTTATGATTATGAAATAAAAACTAAATAACAATTGTCCTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTA
TTTTAAGCAGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAATTCTACACAGTACTTAGATTTTTTTTACTTTCCAGTCCCAGGA
AGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCATGGTGGCTCACTGTCTGTAATGTATTACCTGAGGCAGA
AGACCACCTGAGGGTAGGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCTGTCTCTACAAAAAATAATTAGCCTGGCCTGGTGGTGC
ATGCCTAGTCCTAGCTGATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTAGAGTGAGCTATTATCATGCCACTGTACAGCCTGGGTG
TTCACAGATCTTGTGTCTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCAGAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATG
CATTTAGAGGTGTTCTTCAAGATGACTAATGTCAAAAATTGAGACATCTGTTGCGGTTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTG
GCGTGATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGTGCCTCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGT
GCCACCATGCCCAGCTAATTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTTGACCAGGCTGGTCTCAAACTCTTGACCTCAGCTG
ATGCGCCTGCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGCACCCTACCTCATTTTCTGTAACAAAGCTAAGCTTGAA
CACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGTTTATACATCTTAATTATGGTGGAATTCCTATGTAGAG
TCTAAAAAGCCAGGTACTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAGGCGCAGACTACCTGCAGTGAGGAGGTACTGCTTGTAG
CATATAGAGCCTCTCCCTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAACCTGACCAATTTAAGCCATAAGATCTGGTCAAAGGGAT
ACCCTTCCCACTAAGGACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGCTGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAAAA
CCCCTTCTCTGCCCACCTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAAGTTTGCCTATCCTAGAGGTGGCGGATTTGATCATTTG
GTGTGTTGGGCAATTTTTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCACCACCACCACTTGTGCATCTCAGTCTTGTGTGTTGTC
TGGTTACGTATTCCCTGGGTGATACCATTCAATGTCTTAATGTACTTGTGGCTCAGACCTGAGTGCAAGGTGGAAATAAACATCAAACAT

>In-frame_ENST00000475551_ENST00000468812_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(amino acids)=231AA_start in transcript=679_stop in transcript=1374
MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL
FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI

--------------------------------------------------------------
>In-frame_ENST00000381112_ENST00000451562_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(transcript)=1376nt_BP=946nt
GAAGAAGTGAGCTTGGCCAGAGGCACGCTGTTTAATTTCAAAGTGCTGCTGACTCAAACTCATGAGTCCTGGAGGCAGGTAGAGGCACTT
GTAGGCTGAGGACCCGTAGAGCCCGGTGTGCCCTGCCCAAGCCCCACCTGGGAATGGAGTTATCTCTGTAAAGATCTTGCTGCCTTTGAG
CAAGCACTGCAAATGGGGTAACTGGAACAGCCTTGTCGCGTGTTTCCACCCTTCGTATGAGGCAGGTACCATGGGTCTTCACCAACAGCA
CGGCCTGTTGTCTCCAGGAAATGGTAGCCCCTCACAGTGCTTTCTGTCTGCTTGTTTAGCTTTGGCATTTGAATGTGCAGAATGGTGGAC
TTTGAAATTAATGTCCTTCTGTTGACTGCAGAATTTCTGCTGGAAATGCAGGGAGGCTGCTTGTGGGGTTCGCGTGCTGTGGGAAGTAGG
GAAAATGAGCTGGTTTACTTTGTGTCTTTTTGTGCATGCAGACTGTTTGGATTTTGCCAACAGTTTCTGGGTGCTGCCTGCTTTTTAAAC
TTTTAAAAAATTGTAAACAGCTTCAGTGGCTTTGCAGAAGGAAGCTGTGGTTTCTGGTCTTCCTGTTCAGTCATGTTTTTTTCAGAGGGA
GGGCTAACATCTGGCCATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTC
CAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAA
AGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGT
CGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGC
TCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCAC
ACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTT
GTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTAAGGGTACAACATGGCACA
CTAACCACCTGACTAAATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTACTTTTCTTCAACCTTTGCTTCCACAGACTTTTTCATC

>In-frame_ENST00000381112_ENST00000451562_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(amino acids)=187AA_start in transcript=679_stop in transcript=1242
MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL
FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI

--------------------------------------------------------------
>In-frame_ENST00000381112_ENST00000468812_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(transcript)=3070nt_BP=946nt
GAAGAAGTGAGCTTGGCCAGAGGCACGCTGTTTAATTTCAAAGTGCTGCTGACTCAAACTCATGAGTCCTGGAGGCAGGTAGAGGCACTT
GTAGGCTGAGGACCCGTAGAGCCCGGTGTGCCCTGCCCAAGCCCCACCTGGGAATGGAGTTATCTCTGTAAAGATCTTGCTGCCTTTGAG
CAAGCACTGCAAATGGGGTAACTGGAACAGCCTTGTCGCGTGTTTCCACCCTTCGTATGAGGCAGGTACCATGGGTCTTCACCAACAGCA
CGGCCTGTTGTCTCCAGGAAATGGTAGCCCCTCACAGTGCTTTCTGTCTGCTTGTTTAGCTTTGGCATTTGAATGTGCAGAATGGTGGAC
TTTGAAATTAATGTCCTTCTGTTGACTGCAGAATTTCTGCTGGAAATGCAGGGAGGCTGCTTGTGGGGTTCGCGTGCTGTGGGAAGTAGG
GAAAATGAGCTGGTTTACTTTGTGTCTTTTTGTGCATGCAGACTGTTTGGATTTTGCCAACAGTTTCTGGGTGCTGCCTGCTTTTTAAAC
TTTTAAAAAATTGTAAACAGCTTCAGTGGCTTTGCAGAAGGAAGCTGTGGTTTCTGGTCTTCCTGTTCAGTCATGTTTTTTTCAGAGGGA
GGGCTAACATCTGGCCATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTC
CAAAGAAATTCCTCAAACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAA
AGGTGAAAAGAGTAGAGATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGT
CGAGCCAGACAGACTGCTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGC
TCTGAGCACTGGAGAGAAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCAC
ACGCCATAATGGCACTGGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTT
GTCCATGGCAAATGCTGGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGT
GTTTGGCAAAGTGAAAGAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTGGGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCAT
TGCTGACTGTGGACAACTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACCAGATCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCC
ACCCCATTTGCTCGCAGTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCTTTGGGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTA
GCTGGATTGCAGAGTTAAGTTTATGATTATGAAATAAAAACTAAATAACAATTGTCCTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTA
TTTTAAGCAGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAATTCTACACAGTACTTAGATTTTTTTTACTTTCCAGTCCCAGGA
AGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCATGGTGGCTCACTGTCTGTAATGTATTACCTGAGGCAGA
AGACCACCTGAGGGTAGGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCTGTCTCTACAAAAAATAATTAGCCTGGCCTGGTGGTGC
ATGCCTAGTCCTAGCTGATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTAGAGTGAGCTATTATCATGCCACTGTACAGCCTGGGTG
TTCACAGATCTTGTGTCTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCAGAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATG
CATTTAGAGGTGTTCTTCAAGATGACTAATGTCAAAAATTGAGACATCTGTTGCGGTTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTG
GCGTGATCTCAGCTCACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGTGCCTCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGT
GCCACCATGCCCAGCTAATTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTTGACCAGGCTGGTCTCAAACTCTTGACCTCAGCTG
ATGCGCCTGCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGCACCCTACCTCATTTTCTGTAACAAAGCTAAGCTTGAA
CACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGTTTATACATCTTAATTATGGTGGAATTCCTATGTAGAG
TCTAAAAAGCCAGGTACTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAGGCGCAGACTACCTGCAGTGAGGAGGTACTGCTTGTAG
CATATAGAGCCTCTCCCTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAACCTGACCAATTTAAGCCATAAGATCTGGTCAAAGGGAT
ACCCTTCCCACTAAGGACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGCTGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAAAA
CCCCTTCTCTGCCCACCTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAAGTTTGCCTATCCTAGAGGTGGCGGATTTGATCATTTG
GTGTGTTGGGCAATTTTTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCACCACCACCACTTGTGCATCTCAGTCTTGTGTGTTGTC
TGGTTACGTATTCCCTGGGTGATACCATTCAATGTCTTAATGTACTTGTGGCTCAGACCTGAGTGCAAGGTGGAAATAAACATCAAACAT

>In-frame_ENST00000381112_ENST00000468812_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(amino acids)=231AA_start in transcript=679_stop in transcript=1374
MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL
FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI

--------------------------------------------------------------
>In-frame_ENST00000474617_ENST00000451562_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(transcript)=730nt_BP=300nt
ATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTCCAAAGAAATTCCTCAA
ACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGA
GATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTG
CTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAG
AAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACT
GGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCT
GGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTAAGGGTACAACATGGCACACTAACCACCTGACTAA
ATGAAAAGTTGCCCTGGGGGGAACGGAACAAACACTACTTTTCTTCAACCTTTGCTTCCACAGACTTTTTCATCCCTAAGATACTAGAAG

>In-frame_ENST00000474617_ENST00000451562_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(amino acids)=187AA_start in transcript=33_stop in transcript=596
MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL
FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI

--------------------------------------------------------------
>In-frame_ENST00000474617_ENST00000468812_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(transcript)=2424nt_BP=300nt
ATATTTTTCAACAAATTCAGAAGTGAGTAGAGAATGCATAGTAGCTGTCGGCAGAGGAGGAACCAGAATCTCTCCAAAGAAATTCCTCAA
ACAGAATTTCACACAGGGTATTCCATGGAGAATGAGCCTGGAATTGTCTCGCCATTTAAACGAGTATTCCTAAAAGGTGAAAAGAGTAGA
GATAAGAAAGCCCATGAGAAGGTGACAGAGAGGCGCCCTCTGCACACTGTGGTGTTGTCATTGCCTGAGCGCGTCGAGCCAGACAGACTG
CTGAGCGACTATATTGAGAAGGAGGTAAAGCTGTTTGCAGACAAGGTCCCAAAGACAGCAGAAAATTTTCGTGCTCTGAGCACTGGAGAG
AAAGGATTTGGTTATAAGGGTTCCTGCTTTCACAGAATTATTCCAGGGTTTATGTGTCAGGGTGGTGACTTCACACGCCATAATGGCACT
GGTGGCAAGTCCATCTATGGGGAGAAATTTGAAGATGAGAACTTCATCCTAAAGCATACGGGTCCTGGCATCTTGTCCATGGCAAATGCT
GGACCCAACACAAATGGTTCCCAGTTTTTCATCTGCACTGCCAAGACTGAGTGGTTGGATGGCAAGCATGTGGTGTTTGGCAAAGTGAAA
GAAGGCATGAATATTGTGGAGGCCATGGAGCGCTTTGGGTCCAGGAATGGCAAGACCAGCAAGAAGATCACCATTGCTGACTGTGGACAA
CTCGAATAAGTTTGACTTGTGTTTTATCTTAACCACCAGATCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCCACCCCATTTGCTCGCA
GTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCTTTGGGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTAGCTGGATTGCAGAGTT
AAGTTTATGATTATGAAATAAAAACTAAATAACAATTGTCCTCGTTTGAGTTAAGAGTGTTGATGTAGGCTTTATTTTAAGCAGTAATGG
GTTACTTCTGAAACATCACTTGTTTGCTTAATTCTACACAGTACTTAGATTTTTTTTACTTTCCAGTCCCAGGAAGTGTCAATGTTTGTT
GAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCATGGTGGCTCACTGTCTGTAATGTATTACCTGAGGCAGAAGACCACCTGAGGGTA
GGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCTGTCTCTACAAAAAATAATTAGCCTGGCCTGGTGGTGCATGCCTAGTCCTAGCT
GATCTGGAGGCTGACGTGGGAGGATTGCTTGAGCCTAGAGTGAGCTATTATCATGCCACTGTACAGCCTGGGTGTTCACAGATCTTGTGT
CTCAAAGGTAGGCAGAGGCAGGAAAAGCAAGGAGCCAGAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATGCATTTAGAGGTGTTCT
TCAAGATGACTAATGTCAAAAATTGAGACATCTGTTGCGGTTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTGGCGTGATCTCAGCTCA
CTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGTGCCTCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGTGCCACCATGCCCAGCT
AATTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTTGACCAGGCTGGTCTCAAACTCTTGACCTCAGCTGATGCGCCTGCCTTGGC
CTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGCACCCTACCTCATTTTCTGTAACAAAGCTAAGCTTGAACACTGTTGATGTTCTT
GAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGTTTATACATCTTAATTATGGTGGAATTCCTATGTAGAGTCTAAAAAGCCAGGTA
CTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAGGCGCAGACTACCTGCAGTGAGGAGGTACTGCTTGTAGCATATAGAGCCTCTCC
CTAGCTTTGGTTATGGAGGCTTTGAGGTTTTGCAAACCTGACCAATTTAAGCCATAAGATCTGGTCAAAGGGATACCCTTCCCACTAAGG
ACTTGGTTTCTCAGGAAATTATATGTACAGTGCTTGCTGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAAAACCCCTTCTCTGCCCAC
CTTAACAGACCTCTAGGGTTCTTAACCCAGCAATCAAGTTTGCCTATCCTAGAGGTGGCGGATTTGATCATTTGGTGTGTTGGGCAATTT
TTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCACCACCACCACTTGTGCATCTCAGTCTTGTGTGTTGTCTGGTTACGTATTCCCT

>In-frame_ENST00000474617_ENST00000468812_TCGA-A7-A26G_CCM2_chr7_45078025_+_PPIA_chr7_44838845_length(amino acids)=231AA_start in transcript=33_stop in transcript=728
MHSSCRQRRNQNLSKEIPQTEFHTGYSMENEPGIVSPFKRVFLKGEKSRDKKAHEKVTERRPLHTVVLSLPERVEPDRLLSDYIEKEVKL
FADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGFMCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCM2-PPIA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCM2-PPIA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCM2-PPIA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCM2C1864041CEREBRAL CAVERNOUS MALFORMATIONS 23CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCCM2C2919945Cavernous Hemangioma of Brain2CTD_human;GENOMICS_ENGLAND
HgeneCCM2C0752160Hemangioma, Cavernous, Central Nervous System1CTD_human
HgeneCCM2C0752161Cavernous Hemangioma, Extracerebral1CTD_human
HgeneCCM2C0752164Cavernous Hemangioma, Intracerebral1CTD_human
HgeneCCM2C1140710Cerebral Cavernous Hemangioma1CTD_human
HgeneCCM2C1956260Cavernous Angioma, Central Nervous System1CTD_human
HgeneCCM2C4747394CAPILLARY MALFORMATION-ARTERIOVENOUS MALFORMATION 11GENOMICS_ENGLAND
TgenePPIAC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgenePPIAC0007137Squamous cell carcinoma1CTD_human
TgenePPIAC0024623Malignant neoplasm of stomach1CTD_human
TgenePPIAC0026640Mouth Neoplasms1CTD_human
TgenePPIAC0027627Neoplasm Metastasis1CTD_human
TgenePPIAC0036341Schizophrenia1PSYGENET
TgenePPIAC0038356Stomach Neoplasms1CTD_human
TgenePPIAC0153381Malignant neoplasm of mouth1CTD_human
TgenePPIAC1708349Hereditary Diffuse Gastric Cancer1CTD_human