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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCND3-EXOC4 (FusionGDB2 ID:14158)

Fusion Gene Summary for CCND3-EXOC4

check button Fusion gene summary
Fusion gene informationFusion gene name: CCND3-EXOC4
Fusion gene ID: 14158
HgeneTgene
Gene symbol

CCND3

EXOC4

Gene ID

896

60412

Gene namecyclin D3exocyst complex component 4
Synonyms-SEC8|SEC8L1|Sec8p
Cytomap

6p21.1

7q33

Type of geneprotein-codingprotein-coding
DescriptionG1/S-specific cyclin-D3D3-type cyclinexocyst complex component 4SEC8-like 1exocyst complex component Sec8
Modification date2020031320200320
UniProtAcc.

Q96A65

Ensembl transtripts involved in fusion geneENST00000511642, ENST00000415497, 
ENST00000372988, ENST00000510503, 
ENST00000511686, ENST00000372991, 
ENST00000372987, ENST00000414200, 
ENST00000253861, ENST00000539845, 
ENST00000393161, ENST00000545148, 
ENST00000460346, ENST00000541309, 
Fusion gene scores* DoF score17 X 5 X 11=93535 X 25 X 10=8750
# samples 2139
** MAII scorelog2(21/935*10)=-2.15457703710888
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(39/8750*10)=-4.48773698785744
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCND3 [Title/Abstract] AND EXOC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCND3(42016239)-EXOC4(133682245), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCCND3

GO:0001934

positive regulation of protein phosphorylation

8114739

HgeneCCND3

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

8114739


check buttonFusion gene breakpoints across CCND3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EXOC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-8474-01ACCND3chr6

42016239

-EXOC4chr7

133682245

+


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Fusion Gene ORF analysis for CCND3-EXOC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000511642ENST00000253861CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-3CDSENST00000511642ENST00000539845CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000511642ENST00000393161CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000511642ENST00000545148CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000511642ENST00000460346CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000511642ENST00000541309CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-3CDSENST00000415497ENST00000253861CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-3CDSENST00000415497ENST00000539845CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000415497ENST00000393161CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000415497ENST00000545148CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000415497ENST00000460346CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000415497ENST00000541309CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-3CDSENST00000372988ENST00000253861CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-3CDSENST00000372988ENST00000539845CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000372988ENST00000393161CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000372988ENST00000545148CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000372988ENST00000460346CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000372988ENST00000541309CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-3CDSENST00000510503ENST00000253861CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-3CDSENST00000510503ENST00000539845CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000510503ENST00000393161CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000510503ENST00000545148CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000510503ENST00000460346CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000510503ENST00000541309CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-3CDSENST00000511686ENST00000253861CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-3CDSENST00000511686ENST00000539845CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000511686ENST00000393161CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000511686ENST00000545148CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000511686ENST00000460346CCND3chr6

42016239

-EXOC4chr7

133682245

+
5UTR-intronENST00000511686ENST00000541309CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-3CDSENST00000372991ENST00000253861CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-3CDSENST00000372991ENST00000539845CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000372991ENST00000393161CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000372991ENST00000545148CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000372991ENST00000460346CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000372991ENST00000541309CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-3CDSENST00000372987ENST00000253861CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-3CDSENST00000372987ENST00000539845CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000372987ENST00000393161CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000372987ENST00000545148CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000372987ENST00000460346CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000372987ENST00000541309CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-3CDSENST00000414200ENST00000253861CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-3CDSENST00000414200ENST00000539845CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000414200ENST00000393161CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000414200ENST00000545148CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000414200ENST00000460346CCND3chr6

42016239

-EXOC4chr7

133682245

+
intron-intronENST00000414200ENST00000541309CCND3chr6

42016239

-EXOC4chr7

133682245

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CCND3-EXOC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CCND3chr642016238-EXOC4chr7133682244+4.96E-060.999995
CCND3chr642016238-EXOC4chr7133682244+4.96E-060.999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCND3-EXOC4


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EXOC4

Q96A65

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CCND3-EXOC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CCND3-EXOC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCND3-EXOC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCND3-EXOC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCND3C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human