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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACER3-PC (FusionGDB2 ID:1420)

Fusion Gene Summary for ACER3-PC

check button Fusion gene summary
Fusion gene informationFusion gene name: ACER3-PC
Fusion gene ID: 1420
HgeneTgene
Gene symbol

ACER3

PC

Gene ID

55331

5624

Gene namealkaline ceramidase 3protein C, inactivator of coagulation factors Va and VIIIa
SynonymsAPHC|PHCA|PLDECOAPC|PC|PROC1|THPH3|THPH4
Cytomap

11q13.5

2q14.3

Type of geneprotein-codingprotein-coding
Descriptionalkaline ceramidase 3alkCDase 3alkaline CDase 3alkaline dihydroceramidase SB89alkaline phytoceramidasephytoceramidase, alkalinevitamin K-dependent protein CProtein C-Nagoyaactivated protein Canticoagulant protein Cautoprothrombin IIAblood coagulation factor XIVprepro-protein Ctype I protein C
Modification date2020032020200313
UniProtAcc

Q9NUN7

Q58A44

Ensembl transtripts involved in fusion geneENST00000532485, ENST00000530182, 
ENST00000526597, ENST00000533873, 
ENST00000538157, ENST00000544113, 
ENST00000393958, ENST00000393960, 
ENST00000355677, ENST00000524491, 
ENST00000529047, ENST00000393955, 
ENST00000528224, 
Fusion gene scores* DoF score14 X 7 X 7=68613 X 8 X 7=728
# samples 1713
** MAII scorelog2(17/686*10)=-2.01267383003511
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/728*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACER3 [Title/Abstract] AND PC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACER3(76670075)-PC(66620854), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACER3

GO:0043067

regulation of programmed cell death

20068046

HgeneACER3

GO:0046512

sphingosine biosynthetic process

20068046

HgeneACER3

GO:0046514

ceramide catabolic process

30575723

HgeneACER3

GO:0071602

phytosphingosine biosynthetic process

11356846|20068046


check buttonFusion gene breakpoints across ACER3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1EN-01AACER3chr11

76670075

+PCchr11

66620854

-
ChimerDB4BRCATCGA-BH-A1EN-01AACER3chr11

76670075

+PCchr11

66620854

-


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Fusion Gene ORF analysis for ACER3-PC

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000532485ENST00000393958ACER3chr11

76670075

+PCchr11

66620854

-
In-frameENST00000532485ENST00000393960ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000532485ENST00000355677ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000532485ENST00000524491ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000532485ENST00000529047ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000532485ENST00000393955ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000532485ENST00000528224ACER3chr11

76670075

+PCchr11

66620854

-
3UTR-3CDSENST00000530182ENST00000393958ACER3chr11

76670075

+PCchr11

66620854

-
3UTR-3CDSENST00000530182ENST00000393960ACER3chr11

76670075

+PCchr11

66620854

-
3UTR-intronENST00000530182ENST00000355677ACER3chr11

76670075

+PCchr11

66620854

-
3UTR-intronENST00000530182ENST00000524491ACER3chr11

76670075

+PCchr11

66620854

-
3UTR-intronENST00000530182ENST00000529047ACER3chr11

76670075

+PCchr11

66620854

-
3UTR-intronENST00000530182ENST00000393955ACER3chr11

76670075

+PCchr11

66620854

-
3UTR-intronENST00000530182ENST00000528224ACER3chr11

76670075

+PCchr11

66620854

-
intron-3CDSENST00000526597ENST00000393958ACER3chr11

76670075

+PCchr11

66620854

-
intron-3CDSENST00000526597ENST00000393960ACER3chr11

76670075

+PCchr11

66620854

-
intron-intronENST00000526597ENST00000355677ACER3chr11

76670075

+PCchr11

66620854

-
intron-intronENST00000526597ENST00000524491ACER3chr11

76670075

+PCchr11

66620854

-
intron-intronENST00000526597ENST00000529047ACER3chr11

76670075

+PCchr11

66620854

-
intron-intronENST00000526597ENST00000393955ACER3chr11

76670075

+PCchr11

66620854

-
intron-intronENST00000526597ENST00000528224ACER3chr11

76670075

+PCchr11

66620854

-
In-frameENST00000533873ENST00000393958ACER3chr11

76670075

+PCchr11

66620854

-
In-frameENST00000533873ENST00000393960ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000533873ENST00000355677ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000533873ENST00000524491ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000533873ENST00000529047ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000533873ENST00000393955ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000533873ENST00000528224ACER3chr11

76670075

+PCchr11

66620854

-
In-frameENST00000538157ENST00000393958ACER3chr11

76670075

+PCchr11

66620854

-
In-frameENST00000538157ENST00000393960ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000538157ENST00000355677ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000538157ENST00000524491ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000538157ENST00000529047ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000538157ENST00000393955ACER3chr11

76670075

+PCchr11

66620854

-
5CDS-intronENST00000538157ENST00000528224ACER3chr11

76670075

+PCchr11

66620854

-
intron-3CDSENST00000544113ENST00000393958ACER3chr11

76670075

+PCchr11

66620854

-
intron-3CDSENST00000544113ENST00000393960ACER3chr11

76670075

+PCchr11

66620854

-
intron-intronENST00000544113ENST00000355677ACER3chr11

76670075

+PCchr11

66620854

-
intron-intronENST00000544113ENST00000524491ACER3chr11

76670075

+PCchr11

66620854

-
intron-intronENST00000544113ENST00000529047ACER3chr11

76670075

+PCchr11

66620854

-
intron-intronENST00000544113ENST00000393955ACER3chr11

76670075

+PCchr11

66620854

-
intron-intronENST00000544113ENST00000528224ACER3chr11

76670075

+PCchr11

66620854

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000532485ACER3chr1176670075+ENST00000393958PCchr1166620854-2914371802539819
ENST00000532485ACER3chr1176670075+ENST00000393960PCchr1166620854-2913371802539819
ENST00000533873ACER3chr1176670075+ENST00000393958PCchr1166620854-2734191112359782
ENST00000533873ACER3chr1176670075+ENST00000393960PCchr1166620854-2733191112359782
ENST00000538157ACER3chr1176670075+ENST00000393958PCchr1166620854-28813381912506771
ENST00000538157ACER3chr1176670075+ENST00000393960PCchr1166620854-28803381912506771

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000532485ENST00000393958ACER3chr1176670075+PCchr1166620854-0.0015229830.99847704
ENST00000532485ENST00000393960ACER3chr1176670075+PCchr1166620854-0.0015181380.9984819
ENST00000533873ENST00000393958ACER3chr1176670075+PCchr1166620854-0.0040812940.9959187
ENST00000533873ENST00000393960ACER3chr1176670075+PCchr1166620854-0.0040666450.99593335
ENST00000538157ENST00000393958ACER3chr1176670075+PCchr1166620854-0.0048608760.9951391
ENST00000538157ENST00000393960ACER3chr1176670075+PCchr1166620854-0.0048445540.99515545

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Fusion Genomic Features for ACER3-PC


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACER3-PC


check button Go to

FGviewer for the breakpoints of chr11:76670075-chr11:66620854

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACER3

Q9NUN7

PC

Q58A44

FUNCTION: Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:20068046, PubMed:26792856, PubMed:20207939, PubMed:11356846, PubMed:30575723). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20068046). Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma (PubMed:20207939). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (By similarity). By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (By similarity). {ECO:0000250|UniProtKB:Q9D099, ECO:0000269|PubMed:11356846, ECO:0000269|PubMed:20068046, ECO:0000269|PubMed:20207939, ECO:0000269|PubMed:26792856, ECO:0000269|PubMed:30575723, ECO:0000303|PubMed:20068046}.FUNCTION: May be involved in growth and survival of prostate cancer cells through the TAF-Ibeta pathway.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+3111_3389.0268.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+31156_6189.0268.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+31183_8789.0268.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+31134_5589.0268.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+31162_8289.0268.0TransmembraneHelical
TgenePCchr11:76670075chr11:66620854ENST000003939559211109_1178456.01179.0DomainBiotinyl-binding
TgenePCchr11:76670075chr11:66620854ENST00000393955921563_832456.01179.0DomainPyruvate carboxyltransferase
TgenePCchr11:76670075chr11:66620854ENST0000039395810221109_1178456.01179.0DomainBiotinyl-binding
TgenePCchr11:76670075chr11:66620854ENST000003939581022563_832456.01179.0DomainPyruvate carboxyltransferase
TgenePCchr11:76670075chr11:66620854ENST0000039396011231109_1178456.01179.0DomainBiotinyl-binding
TgenePCchr11:76670075chr11:66620854ENST000003939601123563_832456.01179.0DomainPyruvate carboxyltransferase
TgenePCchr11:76670075chr11:66620854ENST00000393955921571_575456.01179.0RegionNote=Substrate binding
TgenePCchr11:76670075chr11:66620854ENST000003939581022571_575456.01179.0RegionNote=Substrate binding
TgenePCchr11:76670075chr11:66620854ENST000003939601123571_575456.01179.0RegionNote=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+311109_11889.0268.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+311140_14189.0268.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+311163_17389.0268.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+311195_21589.0268.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+311237_26789.0268.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+16109_1180.0135.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+16140_1410.0135.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+16163_1730.0135.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+16195_2150.0135.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+161_330.0135.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+16237_2670.0135.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+1656_610.0135.0Topological domainLumenal
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+1683_870.0135.0Topological domainCytoplasmic
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+311119_13989.0268.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+311142_16289.0268.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+311174_19489.0268.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+311216_23689.0268.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:66620854ENST00000532485+31188_10889.0268.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+16119_1390.0135.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+16142_1620.0135.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+16174_1940.0135.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+16216_2360.0135.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+1634_550.0135.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+1662_820.0135.0TransmembraneHelical
HgeneACER3chr11:76670075chr11:66620854ENST00000544113+1688_1080.0135.0TransmembraneHelical
TgenePCchr11:76670075chr11:66620854ENST00000393955921156_353456.01179.0DomainATP-grasp
TgenePCchr11:76670075chr11:66620854ENST0000039395592136_486456.01179.0DomainNote=Biotin carboxylation
TgenePCchr11:76670075chr11:66620854ENST000003939581022156_353456.01179.0DomainATP-grasp
TgenePCchr11:76670075chr11:66620854ENST00000393958102236_486456.01179.0DomainNote=Biotin carboxylation
TgenePCchr11:76670075chr11:66620854ENST000003939601123156_353456.01179.0DomainATP-grasp
TgenePCchr11:76670075chr11:66620854ENST00000393960112336_486456.01179.0DomainNote=Biotin carboxylation


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Fusion Gene Sequence for ACER3-PC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000532485_ENST00000393958_TCGA-BH-A1EN-01A_ACER3_chr11_76670075_+_PC_chr11_66620854_length(transcript)=2914nt_BP=371nt
GGGCGGGGCGCGAGCGAGCGCGCGGGCTGGGCCGGAGCCGGCCTGGTCGCCAGCCTAACCCGGCACAGTGAGCGGAGCGCCTGGGCGGCG
GCGGCGGCGGCGTGATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGGACTGGTGCGAGGAGAACTACT
CCGTGACCTGGTACATCGCCGAGTTCTGGAATACAGTGAGTAACCTGATCATGATTATACCTCCAATGTTCGGTGCAGTTCAGAGTGTTA
GAGACGGTCTGGAAAAGCGGTACATTGCTTCTTATTTAGCACTCACAGTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAAT
ATGAAATGCAGACCAACATCGCCTTCCTGCAGAATGTGCTCAACAACCAGCAGTTCCTGGCAGGCACTGTGGACACCCAGTTCATCGACG
AGAACCCAGAGCTGTTCCAGCTGCGGCCTGCACAGAACCGGGCCCAAAAGCTGTTGCACTACCTCGGCCATGTCATGGTAAACGGTCCAA
CCACCCCGATTCCCGTCAAGGCCAGCCCCAGCCCCACGGACCCCGTTGTCCCTGCAGTGCCCATAGGCCCGCCCCCGGCTGGTTTCAGAG
ACATCCTGCTGCGAGAGGGGCCTGAGGGCTTTGCTCGAGCTGTGCGGAACCACCCGGGGCTGCTGCTGATGGACACGACCTTCAGGGACG
CCCACCAGTCACTGCTGGCCACTCGTGTGCGCACCCACGATCTCAAAAAGATCGCCCCCTATGTTGCCCACAACTTCAGCAAGCTCTTCA
GCATGGAGAACTGGGGAGGAGCCACGTTTGACGTCGCCATGCGCTTCCTGTATGAGTGCCCCTGGCGGCGGCTGCAGGAGCTCCGGGAGC
TCATCCCCAACATCCCTTTCCAGATGCTGCTGCGGGGGGCCAATGCTGTGGGCTACACCAACTACCCAGACAACGTGGTCTTCAAGTTCT
GTGAAGTGGCCAAAGAGAATGGCATGGATGTCTTCCGTGTGTTTGACTCCCTCAACTACTTGCCCAACATGCTGCTGGGCATGGAGGCGG
CAGGAAGTGCCGGAGGCGTGGTGGAGGCTGCCATCTCATACACGGGCGACGTGGCCGACCCCAGCCGCACCAAGTACTCACTGCAGTACT
ACATGGGCTTGGCCGAAGAGCTGGTGCGAGCTGGCACCCACATCCTGTGCATCAAGGACATGGCCGGGCTGCTGAAGCCCACGGCCTGCA
CCATGCTGGTCAGCTCCCTCCGGGACCGCTTCCCCGACCTCCCACTGCACATCCACACCCACGACACGTCAGGGGCAGGCGTGGCAGCCA
TGCTGGCCTGTGCCCAGGCTGGAGCTGATGTGGTGGATGTGGCAGCTGATTCCATGTCTGGGATGACTTCACAGCCCAGCATGGGGGCCC
TGGTGGCCTGTACCAGAGGGACTCCCCTGGACACAGAGGTGCCCATGGAGCGCGTGTTTGACTACAGTGAGTACTGGGAGGGGGCTCGGG
GACTGTACGCGGCCTTCGACTGCACGGCCACCATGAAGTCTGGCAACTCGGACGTGTATGAAAATGAGATCCCAGGGGGCCAGTACACCA
ACCTGCACTTCCAGGCCCACAGCATGGGGCTTGGCTCCAAGTTCAAGGAGGTCAAGAAGGCCTATGTGGAGGCCAACCAGATGCTGGGCG
ATCTCATCAAGGTGACGCCCTCCTCCAAGATCGTGGGGGACCTGGCCCAGTTTATGGTGCAGAATGGATTGAGCCGGGCAGAGGCCGAAG
CTCAGGCGGAAGAGCTGTCCTTTCCCCGCTCCGTGGTGGAGTTCCTGCAGGGCTACATCGGTGTCCCCCATGGGGGGTTCCCCGAACCCT
TTCGCTCTAAGGTACTGAAGGACCTGCCAAGGGTGGAGGGGCGGCCTGGAGCCTCCCTCCCTCCCCTGGATCTGCAGGCACTGGAGAAGG
AGCTGGTAGACCGGCATGGGGAGGAGGTGACGCCGGAAGATGTGCTCTCAGCAGCTATGTACCCCGATGTGTTTGCCCACTTCAAGGACT
TCACTGCCACCTTTGGCCCCCTGGATAGCCTGAATACTCGCCTCTTCCTGCAGGGACCCAAGATCGCAGAGGAGTTTGAGGTGGAGCTGG
AGCGGGGCAAGACGCTGCACATCAAAGCCCTGGCCGTGAGCGACCTGAACCGGGCCGGCCAGAGGCAGGTCTTCTTTGAGCTCAATGGGC
AGCTGCGGTCCATCTTGGTCAAGGACACCCAGGCCATGAAGGAGATGCACTTCCACCCCAAGGCCCTAAAGGACGTGAAGGGCCAGATCG
GGGCGCCCATGCCTGGGAAGGTGATAGACATCAAAGTGGTGGCAGGGGCCAAGGTGGCCAAGGGCCAGCCCCTGTGTGTGCTCAGTGCCA
TGAAGATGGAGACTGTGGTGACCTCACCCATGGAGGGTACTGTCCGCAAGGTTCATGTGACCAAGGACATGACACTGGAAGGTGACGACC
TCATCCTGGAGATCGAGTGATCTTGCCCCAGACCGGCAGCCTGGCCATCCCCAAGCCTTCAACAGAAGCTGTGCTGCCACGGCAGGCCCA
GGCCAGCCAGTGCCCGAGGCCAGGAAGGCCGGGCCGTGGAGGTCCTGTCCACAGCTGGACAGGAGAGACACCGCCTGCGGTGGTTCATTC
CTTTCAGCCATCGTCCTTTCCTCCGGCGGACAGCTGCTTACATGTTCATCTCTTGCCAAATAAGGGTCCCCTCCTCACTGGAGACTACAA
GTGGTGGGTCAGGTGGTCCTAGGACCCAGGGGAGGTTTAGGGGTCCTATCTCCTGGGGGAAGGGGAGATCTAAGATGTCCCAGGTCCTGG

>In-frame_ENST00000532485_ENST00000393958_TCGA-BH-A1EN-01A_ACER3_chr11_76670075_+_PC_chr11_66620854_length(amino acids)=819AA_start in transcript=80_stop in transcript=2539
MGGGGGGVMAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHM
TLKYEMQTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPA
GFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQE
LRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYS
LQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPS
MGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQ
MLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQA
LEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFE
LNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLE

--------------------------------------------------------------
>In-frame_ENST00000532485_ENST00000393960_TCGA-BH-A1EN-01A_ACER3_chr11_76670075_+_PC_chr11_66620854_length(transcript)=2913nt_BP=371nt
GGGCGGGGCGCGAGCGAGCGCGCGGGCTGGGCCGGAGCCGGCCTGGTCGCCAGCCTAACCCGGCACAGTGAGCGGAGCGCCTGGGCGGCG
GCGGCGGCGGCGTGATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGGACTGGTGCGAGGAGAACTACT
CCGTGACCTGGTACATCGCCGAGTTCTGGAATACAGTGAGTAACCTGATCATGATTATACCTCCAATGTTCGGTGCAGTTCAGAGTGTTA
GAGACGGTCTGGAAAAGCGGTACATTGCTTCTTATTTAGCACTCACAGTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAAT
ATGAAATGCAGACCAACATCGCCTTCCTGCAGAATGTGCTCAACAACCAGCAGTTCCTGGCAGGCACTGTGGACACCCAGTTCATCGACG
AGAACCCAGAGCTGTTCCAGCTGCGGCCTGCACAGAACCGGGCCCAAAAGCTGTTGCACTACCTCGGCCATGTCATGGTAAACGGTCCAA
CCACCCCGATTCCCGTCAAGGCCAGCCCCAGCCCCACGGACCCCGTTGTCCCTGCAGTGCCCATAGGCCCGCCCCCGGCTGGTTTCAGAG
ACATCCTGCTGCGAGAGGGGCCTGAGGGCTTTGCTCGAGCTGTGCGGAACCACCCGGGGCTGCTGCTGATGGACACGACCTTCAGGGACG
CCCACCAGTCACTGCTGGCCACTCGTGTGCGCACCCACGATCTCAAAAAGATCGCCCCCTATGTTGCCCACAACTTCAGCAAGCTCTTCA
GCATGGAGAACTGGGGAGGAGCCACGTTTGACGTCGCCATGCGCTTCCTGTATGAGTGCCCCTGGCGGCGGCTGCAGGAGCTCCGGGAGC
TCATCCCCAACATCCCTTTCCAGATGCTGCTGCGGGGGGCCAATGCTGTGGGCTACACCAACTACCCAGACAACGTGGTCTTCAAGTTCT
GTGAAGTGGCCAAAGAGAATGGCATGGATGTCTTCCGTGTGTTTGACTCCCTCAACTACTTGCCCAACATGCTGCTGGGCATGGAGGCGG
CAGGAAGTGCCGGAGGCGTGGTGGAGGCTGCCATCTCATACACGGGCGACGTGGCCGACCCCAGCCGCACCAAGTACTCACTGCAGTACT
ACATGGGCTTGGCCGAAGAGCTGGTGCGAGCTGGCACCCACATCCTGTGCATCAAGGACATGGCCGGGCTGCTGAAGCCCACGGCCTGCA
CCATGCTGGTCAGCTCCCTCCGGGACCGCTTCCCCGACCTCCCACTGCACATCCACACCCACGACACGTCAGGGGCAGGCGTGGCAGCCA
TGCTGGCCTGTGCCCAGGCTGGAGCTGATGTGGTGGATGTGGCAGCTGATTCCATGTCTGGGATGACTTCACAGCCCAGCATGGGGGCCC
TGGTGGCCTGTACCAGAGGGACTCCCCTGGACACAGAGGTGCCCATGGAGCGCGTGTTTGACTACAGTGAGTACTGGGAGGGGGCTCGGG
GACTGTACGCGGCCTTCGACTGCACGGCCACCATGAAGTCTGGCAACTCGGACGTGTATGAAAATGAGATCCCAGGGGGCCAGTACACCA
ACCTGCACTTCCAGGCCCACAGCATGGGGCTTGGCTCCAAGTTCAAGGAGGTCAAGAAGGCCTATGTGGAGGCCAACCAGATGCTGGGCG
ATCTCATCAAGGTGACGCCCTCCTCCAAGATCGTGGGGGACCTGGCCCAGTTTATGGTGCAGAATGGATTGAGCCGGGCAGAGGCCGAAG
CTCAGGCGGAAGAGCTGTCCTTTCCCCGCTCCGTGGTGGAGTTCCTGCAGGGCTACATCGGTGTCCCCCATGGGGGGTTCCCCGAACCCT
TTCGCTCTAAGGTACTGAAGGACCTGCCAAGGGTGGAGGGGCGGCCTGGAGCCTCCCTCCCTCCCCTGGATCTGCAGGCACTGGAGAAGG
AGCTGGTAGACCGGCATGGGGAGGAGGTGACGCCGGAAGATGTGCTCTCAGCAGCTATGTACCCCGATGTGTTTGCCCACTTCAAGGACT
TCACTGCCACCTTTGGCCCCCTGGATAGCCTGAATACTCGCCTCTTCCTGCAGGGACCCAAGATCGCAGAGGAGTTTGAGGTGGAGCTGG
AGCGGGGCAAGACGCTGCACATCAAAGCCCTGGCCGTGAGCGACCTGAACCGGGCCGGCCAGAGGCAGGTCTTCTTTGAGCTCAATGGGC
AGCTGCGGTCCATCTTGGTCAAGGACACCCAGGCCATGAAGGAGATGCACTTCCACCCCAAGGCCCTAAAGGACGTGAAGGGCCAGATCG
GGGCGCCCATGCCTGGGAAGGTGATAGACATCAAAGTGGTGGCAGGGGCCAAGGTGGCCAAGGGCCAGCCCCTGTGTGTGCTCAGTGCCA
TGAAGATGGAGACTGTGGTGACCTCACCCATGGAGGGTACTGTCCGCAAGGTTCATGTGACCAAGGACATGACACTGGAAGGTGACGACC
TCATCCTGGAGATCGAGTGATCTTGCCCCAGACCGGCAGCCTGGCCATCCCCAAGCCTTCAACAGAAGCTGTGCTGCCACGGCAGGCCCA
GGCCAGCCAGTGCCCGAGGCCAGGAAGGCCGGGCCGTGGAGGTCCTGTCCACAGCTGGACAGGAGAGACACCGCCTGCGGTGGTTCATTC
CTTTCAGCCATCGTCCTTTCCTCCGGCGGACAGCTGCTTACATGTTCATCTCTTGCCAAATAAGGGTCCCCTCCTCACTGGAGACTACAA
GTGGTGGGTCAGGTGGTCCTAGGACCCAGGGGAGGTTTAGGGGTCCTATCTCCTGGGGGAAGGGGAGATCTAAGATGTCCCAGGTCCTGG

>In-frame_ENST00000532485_ENST00000393960_TCGA-BH-A1EN-01A_ACER3_chr11_76670075_+_PC_chr11_66620854_length(amino acids)=819AA_start in transcript=80_stop in transcript=2539
MGGGGGGVMAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHM
TLKYEMQTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPA
GFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQE
LRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYS
LQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPS
MGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQ
MLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQA
LEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFE
LNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVAGAKVAKGQPLCVLSAMKMETVVTSPMEGTVRKVHVTKDMTLE

--------------------------------------------------------------
>In-frame_ENST00000533873_ENST00000393958_TCGA-BH-A1EN-01A_ACER3_chr11_76670075_+_PC_chr11_66620854_length(transcript)=2734nt_BP=191nt
GAGCGGAGCGCCTGGGCGGCGGCGGCGGCGGCGTGATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGG
ACTGGTGCGAGGAGAACTACTCCGTGACCTGGTACATCGCCGAGTTCTTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAAT
ATGAAATGCAGACCAACATCGCCTTCCTGCAGAATGTGCTCAACAACCAGCAGTTCCTGGCAGGCACTGTGGACACCCAGTTCATCGACG
AGAACCCAGAGCTGTTCCAGCTGCGGCCTGCACAGAACCGGGCCCAAAAGCTGTTGCACTACCTCGGCCATGTCATGGTAAACGGTCCAA
CCACCCCGATTCCCGTCAAGGCCAGCCCCAGCCCCACGGACCCCGTTGTCCCTGCAGTGCCCATAGGCCCGCCCCCGGCTGGTTTCAGAG
ACATCCTGCTGCGAGAGGGGCCTGAGGGCTTTGCTCGAGCTGTGCGGAACCACCCGGGGCTGCTGCTGATGGACACGACCTTCAGGGACG
CCCACCAGTCACTGCTGGCCACTCGTGTGCGCACCCACGATCTCAAAAAGATCGCCCCCTATGTTGCCCACAACTTCAGCAAGCTCTTCA
GCATGGAGAACTGGGGAGGAGCCACGTTTGACGTCGCCATGCGCTTCCTGTATGAGTGCCCCTGGCGGCGGCTGCAGGAGCTCCGGGAGC
TCATCCCCAACATCCCTTTCCAGATGCTGCTGCGGGGGGCCAATGCTGTGGGCTACACCAACTACCCAGACAACGTGGTCTTCAAGTTCT
GTGAAGTGGCCAAAGAGAATGGCATGGATGTCTTCCGTGTGTTTGACTCCCTCAACTACTTGCCCAACATGCTGCTGGGCATGGAGGCGG
CAGGAAGTGCCGGAGGCGTGGTGGAGGCTGCCATCTCATACACGGGCGACGTGGCCGACCCCAGCCGCACCAAGTACTCACTGCAGTACT
ACATGGGCTTGGCCGAAGAGCTGGTGCGAGCTGGCACCCACATCCTGTGCATCAAGGACATGGCCGGGCTGCTGAAGCCCACGGCCTGCA
CCATGCTGGTCAGCTCCCTCCGGGACCGCTTCCCCGACCTCCCACTGCACATCCACACCCACGACACGTCAGGGGCAGGCGTGGCAGCCA
TGCTGGCCTGTGCCCAGGCTGGAGCTGATGTGGTGGATGTGGCAGCTGATTCCATGTCTGGGATGACTTCACAGCCCAGCATGGGGGCCC
TGGTGGCCTGTACCAGAGGGACTCCCCTGGACACAGAGGTGCCCATGGAGCGCGTGTTTGACTACAGTGAGTACTGGGAGGGGGCTCGGG
GACTGTACGCGGCCTTCGACTGCACGGCCACCATGAAGTCTGGCAACTCGGACGTGTATGAAAATGAGATCCCAGGGGGCCAGTACACCA
ACCTGCACTTCCAGGCCCACAGCATGGGGCTTGGCTCCAAGTTCAAGGAGGTCAAGAAGGCCTATGTGGAGGCCAACCAGATGCTGGGCG
ATCTCATCAAGGTGACGCCCTCCTCCAAGATCGTGGGGGACCTGGCCCAGTTTATGGTGCAGAATGGATTGAGCCGGGCAGAGGCCGAAG
CTCAGGCGGAAGAGCTGTCCTTTCCCCGCTCCGTGGTGGAGTTCCTGCAGGGCTACATCGGTGTCCCCCATGGGGGGTTCCCCGAACCCT
TTCGCTCTAAGGTACTGAAGGACCTGCCAAGGGTGGAGGGGCGGCCTGGAGCCTCCCTCCCTCCCCTGGATCTGCAGGCACTGGAGAAGG
AGCTGGTAGACCGGCATGGGGAGGAGGTGACGCCGGAAGATGTGCTCTCAGCAGCTATGTACCCCGATGTGTTTGCCCACTTCAAGGACT
TCACTGCCACCTTTGGCCCCCTGGATAGCCTGAATACTCGCCTCTTCCTGCAGGGACCCAAGATCGCAGAGGAGTTTGAGGTGGAGCTGG
AGCGGGGCAAGACGCTGCACATCAAAGCCCTGGCCGTGAGCGACCTGAACCGGGCCGGCCAGAGGCAGGTCTTCTTTGAGCTCAATGGGC
AGCTGCGGTCCATCTTGGTCAAGGACACCCAGGCCATGAAGGAGATGCACTTCCACCCCAAGGCCCTAAAGGACGTGAAGGGCCAGATCG
GGGCGCCCATGCCTGGGAAGGTGATAGACATCAAAGTGGTGGCAGGGGCCAAGGTGGCCAAGGGCCAGCCCCTGTGTGTGCTCAGTGCCA
TGAAGATGGAGACTGTGGTGACCTCACCCATGGAGGGTACTGTCCGCAAGGTTCATGTGACCAAGGACATGACACTGGAAGGTGACGACC
TCATCCTGGAGATCGAGTGATCTTGCCCCAGACCGGCAGCCTGGCCATCCCCAAGCCTTCAACAGAAGCTGTGCTGCCACGGCAGGCCCA
GGCCAGCCAGTGCCCGAGGCCAGGAAGGCCGGGCCGTGGAGGTCCTGTCCACAGCTGGACAGGAGAGACACCGCCTGCGGTGGTTCATTC
CTTTCAGCCATCGTCCTTTCCTCCGGCGGACAGCTGCTTACATGTTCATCTCTTGCCAAATAAGGGTCCCCTCCTCACTGGAGACTACAA
GTGGTGGGTCAGGTGGTCCTAGGACCCAGGGGAGGTTTAGGGGTCCTATCTCCTGGGGGAAGGGGAGATCTAAGATGTCCCAGGTCCTGG

>In-frame_ENST00000533873_ENST00000393958_TCGA-BH-A1EN-01A_ACER3_chr11_76670075_+_PC_chr11_66620854_length(amino acids)=782AA_start in transcript=11_stop in transcript=2359
MGGGGGGVMAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFLVGMGSWCFHMTLKYEMQTNIAFLQNVLNNQQFLAGTVDTQFIDENPE
LFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQS
LLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVA
KENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLV
SSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYA
AFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAE
ELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTAT
FGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPM

--------------------------------------------------------------
>In-frame_ENST00000533873_ENST00000393960_TCGA-BH-A1EN-01A_ACER3_chr11_76670075_+_PC_chr11_66620854_length(transcript)=2733nt_BP=191nt
GAGCGGAGCGCCTGGGCGGCGGCGGCGGCGGCGTGATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGG
ACTGGTGCGAGGAGAACTACTCCGTGACCTGGTACATCGCCGAGTTCTTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAAT
ATGAAATGCAGACCAACATCGCCTTCCTGCAGAATGTGCTCAACAACCAGCAGTTCCTGGCAGGCACTGTGGACACCCAGTTCATCGACG
AGAACCCAGAGCTGTTCCAGCTGCGGCCTGCACAGAACCGGGCCCAAAAGCTGTTGCACTACCTCGGCCATGTCATGGTAAACGGTCCAA
CCACCCCGATTCCCGTCAAGGCCAGCCCCAGCCCCACGGACCCCGTTGTCCCTGCAGTGCCCATAGGCCCGCCCCCGGCTGGTTTCAGAG
ACATCCTGCTGCGAGAGGGGCCTGAGGGCTTTGCTCGAGCTGTGCGGAACCACCCGGGGCTGCTGCTGATGGACACGACCTTCAGGGACG
CCCACCAGTCACTGCTGGCCACTCGTGTGCGCACCCACGATCTCAAAAAGATCGCCCCCTATGTTGCCCACAACTTCAGCAAGCTCTTCA
GCATGGAGAACTGGGGAGGAGCCACGTTTGACGTCGCCATGCGCTTCCTGTATGAGTGCCCCTGGCGGCGGCTGCAGGAGCTCCGGGAGC
TCATCCCCAACATCCCTTTCCAGATGCTGCTGCGGGGGGCCAATGCTGTGGGCTACACCAACTACCCAGACAACGTGGTCTTCAAGTTCT
GTGAAGTGGCCAAAGAGAATGGCATGGATGTCTTCCGTGTGTTTGACTCCCTCAACTACTTGCCCAACATGCTGCTGGGCATGGAGGCGG
CAGGAAGTGCCGGAGGCGTGGTGGAGGCTGCCATCTCATACACGGGCGACGTGGCCGACCCCAGCCGCACCAAGTACTCACTGCAGTACT
ACATGGGCTTGGCCGAAGAGCTGGTGCGAGCTGGCACCCACATCCTGTGCATCAAGGACATGGCCGGGCTGCTGAAGCCCACGGCCTGCA
CCATGCTGGTCAGCTCCCTCCGGGACCGCTTCCCCGACCTCCCACTGCACATCCACACCCACGACACGTCAGGGGCAGGCGTGGCAGCCA
TGCTGGCCTGTGCCCAGGCTGGAGCTGATGTGGTGGATGTGGCAGCTGATTCCATGTCTGGGATGACTTCACAGCCCAGCATGGGGGCCC
TGGTGGCCTGTACCAGAGGGACTCCCCTGGACACAGAGGTGCCCATGGAGCGCGTGTTTGACTACAGTGAGTACTGGGAGGGGGCTCGGG
GACTGTACGCGGCCTTCGACTGCACGGCCACCATGAAGTCTGGCAACTCGGACGTGTATGAAAATGAGATCCCAGGGGGCCAGTACACCA
ACCTGCACTTCCAGGCCCACAGCATGGGGCTTGGCTCCAAGTTCAAGGAGGTCAAGAAGGCCTATGTGGAGGCCAACCAGATGCTGGGCG
ATCTCATCAAGGTGACGCCCTCCTCCAAGATCGTGGGGGACCTGGCCCAGTTTATGGTGCAGAATGGATTGAGCCGGGCAGAGGCCGAAG
CTCAGGCGGAAGAGCTGTCCTTTCCCCGCTCCGTGGTGGAGTTCCTGCAGGGCTACATCGGTGTCCCCCATGGGGGGTTCCCCGAACCCT
TTCGCTCTAAGGTACTGAAGGACCTGCCAAGGGTGGAGGGGCGGCCTGGAGCCTCCCTCCCTCCCCTGGATCTGCAGGCACTGGAGAAGG
AGCTGGTAGACCGGCATGGGGAGGAGGTGACGCCGGAAGATGTGCTCTCAGCAGCTATGTACCCCGATGTGTTTGCCCACTTCAAGGACT
TCACTGCCACCTTTGGCCCCCTGGATAGCCTGAATACTCGCCTCTTCCTGCAGGGACCCAAGATCGCAGAGGAGTTTGAGGTGGAGCTGG
AGCGGGGCAAGACGCTGCACATCAAAGCCCTGGCCGTGAGCGACCTGAACCGGGCCGGCCAGAGGCAGGTCTTCTTTGAGCTCAATGGGC
AGCTGCGGTCCATCTTGGTCAAGGACACCCAGGCCATGAAGGAGATGCACTTCCACCCCAAGGCCCTAAAGGACGTGAAGGGCCAGATCG
GGGCGCCCATGCCTGGGAAGGTGATAGACATCAAAGTGGTGGCAGGGGCCAAGGTGGCCAAGGGCCAGCCCCTGTGTGTGCTCAGTGCCA
TGAAGATGGAGACTGTGGTGACCTCACCCATGGAGGGTACTGTCCGCAAGGTTCATGTGACCAAGGACATGACACTGGAAGGTGACGACC
TCATCCTGGAGATCGAGTGATCTTGCCCCAGACCGGCAGCCTGGCCATCCCCAAGCCTTCAACAGAAGCTGTGCTGCCACGGCAGGCCCA
GGCCAGCCAGTGCCCGAGGCCAGGAAGGCCGGGCCGTGGAGGTCCTGTCCACAGCTGGACAGGAGAGACACCGCCTGCGGTGGTTCATTC
CTTTCAGCCATCGTCCTTTCCTCCGGCGGACAGCTGCTTACATGTTCATCTCTTGCCAAATAAGGGTCCCCTCCTCACTGGAGACTACAA
GTGGTGGGTCAGGTGGTCCTAGGACCCAGGGGAGGTTTAGGGGTCCTATCTCCTGGGGGAAGGGGAGATCTAAGATGTCCCAGGTCCTGG

>In-frame_ENST00000533873_ENST00000393960_TCGA-BH-A1EN-01A_ACER3_chr11_76670075_+_PC_chr11_66620854_length(amino acids)=782AA_start in transcript=11_stop in transcript=2359
MGGGGGGVMAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFLVGMGSWCFHMTLKYEMQTNIAFLQNVLNNQQFLAGTVDTQFIDENPE
LFQLRPAQNRAQKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQS
LLATRVRTHDLKKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVA
KENGMDVFRVFDSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLV
SSLRDRFPDLPLHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYA
AFDCTATMKSGNSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAE
ELSFPRSVVEFLQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTAT
FGPLDSLNTRLFLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPM

--------------------------------------------------------------
>In-frame_ENST00000538157_ENST00000393958_TCGA-BH-A1EN-01A_ACER3_chr11_76670075_+_PC_chr11_66620854_length(transcript)=2881nt_BP=338nt
AGCGGAGCGCCTGGGCGGCGGCGGCGGCGGCGTGATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGGA
CTGGTGCGAGGAGAACTACTCCGTGACCTGGTACATCGCCGAGTTCTGTTCCTTCCTACCATCCTCCCTGAAGAGCAACCTCAAGGAATA
CAGTGAGTAACCTGATCATGATTATACCTCCAATGTTCGGTGCAGTTCAGAGTGTTAGAGACGGTCTGGAAAAGCGGTACATTGCTTCTT
ATTTAGCACTCACAGTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAATATGAAATGCAGACCAACATCGCCTTCCTGCAGA
ATGTGCTCAACAACCAGCAGTTCCTGGCAGGCACTGTGGACACCCAGTTCATCGACGAGAACCCAGAGCTGTTCCAGCTGCGGCCTGCAC
AGAACCGGGCCCAAAAGCTGTTGCACTACCTCGGCCATGTCATGGTAAACGGTCCAACCACCCCGATTCCCGTCAAGGCCAGCCCCAGCC
CCACGGACCCCGTTGTCCCTGCAGTGCCCATAGGCCCGCCCCCGGCTGGTTTCAGAGACATCCTGCTGCGAGAGGGGCCTGAGGGCTTTG
CTCGAGCTGTGCGGAACCACCCGGGGCTGCTGCTGATGGACACGACCTTCAGGGACGCCCACCAGTCACTGCTGGCCACTCGTGTGCGCA
CCCACGATCTCAAAAAGATCGCCCCCTATGTTGCCCACAACTTCAGCAAGCTCTTCAGCATGGAGAACTGGGGAGGAGCCACGTTTGACG
TCGCCATGCGCTTCCTGTATGAGTGCCCCTGGCGGCGGCTGCAGGAGCTCCGGGAGCTCATCCCCAACATCCCTTTCCAGATGCTGCTGC
GGGGGGCCAATGCTGTGGGCTACACCAACTACCCAGACAACGTGGTCTTCAAGTTCTGTGAAGTGGCCAAAGAGAATGGCATGGATGTCT
TCCGTGTGTTTGACTCCCTCAACTACTTGCCCAACATGCTGCTGGGCATGGAGGCGGCAGGAAGTGCCGGAGGCGTGGTGGAGGCTGCCA
TCTCATACACGGGCGACGTGGCCGACCCCAGCCGCACCAAGTACTCACTGCAGTACTACATGGGCTTGGCCGAAGAGCTGGTGCGAGCTG
GCACCCACATCCTGTGCATCAAGGACATGGCCGGGCTGCTGAAGCCCACGGCCTGCACCATGCTGGTCAGCTCCCTCCGGGACCGCTTCC
CCGACCTCCCACTGCACATCCACACCCACGACACGTCAGGGGCAGGCGTGGCAGCCATGCTGGCCTGTGCCCAGGCTGGAGCTGATGTGG
TGGATGTGGCAGCTGATTCCATGTCTGGGATGACTTCACAGCCCAGCATGGGGGCCCTGGTGGCCTGTACCAGAGGGACTCCCCTGGACA
CAGAGGTGCCCATGGAGCGCGTGTTTGACTACAGTGAGTACTGGGAGGGGGCTCGGGGACTGTACGCGGCCTTCGACTGCACGGCCACCA
TGAAGTCTGGCAACTCGGACGTGTATGAAAATGAGATCCCAGGGGGCCAGTACACCAACCTGCACTTCCAGGCCCACAGCATGGGGCTTG
GCTCCAAGTTCAAGGAGGTCAAGAAGGCCTATGTGGAGGCCAACCAGATGCTGGGCGATCTCATCAAGGTGACGCCCTCCTCCAAGATCG
TGGGGGACCTGGCCCAGTTTATGGTGCAGAATGGATTGAGCCGGGCAGAGGCCGAAGCTCAGGCGGAAGAGCTGTCCTTTCCCCGCTCCG
TGGTGGAGTTCCTGCAGGGCTACATCGGTGTCCCCCATGGGGGGTTCCCCGAACCCTTTCGCTCTAAGGTACTGAAGGACCTGCCAAGGG
TGGAGGGGCGGCCTGGAGCCTCCCTCCCTCCCCTGGATCTGCAGGCACTGGAGAAGGAGCTGGTAGACCGGCATGGGGAGGAGGTGACGC
CGGAAGATGTGCTCTCAGCAGCTATGTACCCCGATGTGTTTGCCCACTTCAAGGACTTCACTGCCACCTTTGGCCCCCTGGATAGCCTGA
ATACTCGCCTCTTCCTGCAGGGACCCAAGATCGCAGAGGAGTTTGAGGTGGAGCTGGAGCGGGGCAAGACGCTGCACATCAAAGCCCTGG
CCGTGAGCGACCTGAACCGGGCCGGCCAGAGGCAGGTCTTCTTTGAGCTCAATGGGCAGCTGCGGTCCATCTTGGTCAAGGACACCCAGG
CCATGAAGGAGATGCACTTCCACCCCAAGGCCCTAAAGGACGTGAAGGGCCAGATCGGGGCGCCCATGCCTGGGAAGGTGATAGACATCA
AAGTGGTGGCAGGGGCCAAGGTGGCCAAGGGCCAGCCCCTGTGTGTGCTCAGTGCCATGAAGATGGAGACTGTGGTGACCTCACCCATGG
AGGGTACTGTCCGCAAGGTTCATGTGACCAAGGACATGACACTGGAAGGTGACGACCTCATCCTGGAGATCGAGTGATCTTGCCCCAGAC
CGGCAGCCTGGCCATCCCCAAGCCTTCAACAGAAGCTGTGCTGCCACGGCAGGCCCAGGCCAGCCAGTGCCCGAGGCCAGGAAGGCCGGG
CCGTGGAGGTCCTGTCCACAGCTGGACAGGAGAGACACCGCCTGCGGTGGTTCATTCCTTTCAGCCATCGTCCTTTCCTCCGGCGGACAG
CTGCTTACATGTTCATCTCTTGCCAAATAAGGGTCCCCTCCTCACTGGAGACTACAAGTGGTGGGTCAGGTGGTCCTAGGACCCAGGGGA
GGTTTAGGGGTCCTATCTCCTGGGGGAAGGGGAGATCTAAGATGTCCCAGGTCCTGGGAAGTTTACTCAATAAAGCTGGCTTTCCCCTGC

>In-frame_ENST00000538157_ENST00000393958_TCGA-BH-A1EN-01A_ACER3_chr11_76670075_+_PC_chr11_66620854_length(amino acids)=771AA_start in transcript=191_stop in transcript=2506
MIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRA
QKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDL
KKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVF
DSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLP
LHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSG
NSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEF
LQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRL
FLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVA

--------------------------------------------------------------
>In-frame_ENST00000538157_ENST00000393960_TCGA-BH-A1EN-01A_ACER3_chr11_76670075_+_PC_chr11_66620854_length(transcript)=2880nt_BP=338nt
AGCGGAGCGCCTGGGCGGCGGCGGCGGCGGCGTGATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGGA
CTGGTGCGAGGAGAACTACTCCGTGACCTGGTACATCGCCGAGTTCTGTTCCTTCCTACCATCCTCCCTGAAGAGCAACCTCAAGGAATA
CAGTGAGTAACCTGATCATGATTATACCTCCAATGTTCGGTGCAGTTCAGAGTGTTAGAGACGGTCTGGAAAAGCGGTACATTGCTTCTT
ATTTAGCACTCACAGTGGTAGGAATGGGATCCTGGTGCTTCCACATGACTCTGAAATATGAAATGCAGACCAACATCGCCTTCCTGCAGA
ATGTGCTCAACAACCAGCAGTTCCTGGCAGGCACTGTGGACACCCAGTTCATCGACGAGAACCCAGAGCTGTTCCAGCTGCGGCCTGCAC
AGAACCGGGCCCAAAAGCTGTTGCACTACCTCGGCCATGTCATGGTAAACGGTCCAACCACCCCGATTCCCGTCAAGGCCAGCCCCAGCC
CCACGGACCCCGTTGTCCCTGCAGTGCCCATAGGCCCGCCCCCGGCTGGTTTCAGAGACATCCTGCTGCGAGAGGGGCCTGAGGGCTTTG
CTCGAGCTGTGCGGAACCACCCGGGGCTGCTGCTGATGGACACGACCTTCAGGGACGCCCACCAGTCACTGCTGGCCACTCGTGTGCGCA
CCCACGATCTCAAAAAGATCGCCCCCTATGTTGCCCACAACTTCAGCAAGCTCTTCAGCATGGAGAACTGGGGAGGAGCCACGTTTGACG
TCGCCATGCGCTTCCTGTATGAGTGCCCCTGGCGGCGGCTGCAGGAGCTCCGGGAGCTCATCCCCAACATCCCTTTCCAGATGCTGCTGC
GGGGGGCCAATGCTGTGGGCTACACCAACTACCCAGACAACGTGGTCTTCAAGTTCTGTGAAGTGGCCAAAGAGAATGGCATGGATGTCT
TCCGTGTGTTTGACTCCCTCAACTACTTGCCCAACATGCTGCTGGGCATGGAGGCGGCAGGAAGTGCCGGAGGCGTGGTGGAGGCTGCCA
TCTCATACACGGGCGACGTGGCCGACCCCAGCCGCACCAAGTACTCACTGCAGTACTACATGGGCTTGGCCGAAGAGCTGGTGCGAGCTG
GCACCCACATCCTGTGCATCAAGGACATGGCCGGGCTGCTGAAGCCCACGGCCTGCACCATGCTGGTCAGCTCCCTCCGGGACCGCTTCC
CCGACCTCCCACTGCACATCCACACCCACGACACGTCAGGGGCAGGCGTGGCAGCCATGCTGGCCTGTGCCCAGGCTGGAGCTGATGTGG
TGGATGTGGCAGCTGATTCCATGTCTGGGATGACTTCACAGCCCAGCATGGGGGCCCTGGTGGCCTGTACCAGAGGGACTCCCCTGGACA
CAGAGGTGCCCATGGAGCGCGTGTTTGACTACAGTGAGTACTGGGAGGGGGCTCGGGGACTGTACGCGGCCTTCGACTGCACGGCCACCA
TGAAGTCTGGCAACTCGGACGTGTATGAAAATGAGATCCCAGGGGGCCAGTACACCAACCTGCACTTCCAGGCCCACAGCATGGGGCTTG
GCTCCAAGTTCAAGGAGGTCAAGAAGGCCTATGTGGAGGCCAACCAGATGCTGGGCGATCTCATCAAGGTGACGCCCTCCTCCAAGATCG
TGGGGGACCTGGCCCAGTTTATGGTGCAGAATGGATTGAGCCGGGCAGAGGCCGAAGCTCAGGCGGAAGAGCTGTCCTTTCCCCGCTCCG
TGGTGGAGTTCCTGCAGGGCTACATCGGTGTCCCCCATGGGGGGTTCCCCGAACCCTTTCGCTCTAAGGTACTGAAGGACCTGCCAAGGG
TGGAGGGGCGGCCTGGAGCCTCCCTCCCTCCCCTGGATCTGCAGGCACTGGAGAAGGAGCTGGTAGACCGGCATGGGGAGGAGGTGACGC
CGGAAGATGTGCTCTCAGCAGCTATGTACCCCGATGTGTTTGCCCACTTCAAGGACTTCACTGCCACCTTTGGCCCCCTGGATAGCCTGA
ATACTCGCCTCTTCCTGCAGGGACCCAAGATCGCAGAGGAGTTTGAGGTGGAGCTGGAGCGGGGCAAGACGCTGCACATCAAAGCCCTGG
CCGTGAGCGACCTGAACCGGGCCGGCCAGAGGCAGGTCTTCTTTGAGCTCAATGGGCAGCTGCGGTCCATCTTGGTCAAGGACACCCAGG
CCATGAAGGAGATGCACTTCCACCCCAAGGCCCTAAAGGACGTGAAGGGCCAGATCGGGGCGCCCATGCCTGGGAAGGTGATAGACATCA
AAGTGGTGGCAGGGGCCAAGGTGGCCAAGGGCCAGCCCCTGTGTGTGCTCAGTGCCATGAAGATGGAGACTGTGGTGACCTCACCCATGG
AGGGTACTGTCCGCAAGGTTCATGTGACCAAGGACATGACACTGGAAGGTGACGACCTCATCCTGGAGATCGAGTGATCTTGCCCCAGAC
CGGCAGCCTGGCCATCCCCAAGCCTTCAACAGAAGCTGTGCTGCCACGGCAGGCCCAGGCCAGCCAGTGCCCGAGGCCAGGAAGGCCGGG
CCGTGGAGGTCCTGTCCACAGCTGGACAGGAGAGACACCGCCTGCGGTGGTTCATTCCTTTCAGCCATCGTCCTTTCCTCCGGCGGACAG
CTGCTTACATGTTCATCTCTTGCCAAATAAGGGTCCCCTCCTCACTGGAGACTACAAGTGGTGGGTCAGGTGGTCCTAGGACCCAGGGGA
GGTTTAGGGGTCCTATCTCCTGGGGGAAGGGGAGATCTAAGATGTCCCAGGTCCTGGGAAGTTTACTCAATAAAGCTGGCTTTCCCCTGC

>In-frame_ENST00000538157_ENST00000393960_TCGA-BH-A1EN-01A_ACER3_chr11_76670075_+_PC_chr11_66620854_length(amino acids)=771AA_start in transcript=191_stop in transcript=2506
MIMIIPPMFGAVQSVRDGLEKRYIASYLALTVVGMGSWCFHMTLKYEMQTNIAFLQNVLNNQQFLAGTVDTQFIDENPELFQLRPAQNRA
QKLLHYLGHVMVNGPTTPIPVKASPSPTDPVVPAVPIGPPPAGFRDILLREGPEGFARAVRNHPGLLLMDTTFRDAHQSLLATRVRTHDL
KKIAPYVAHNFSKLFSMENWGGATFDVAMRFLYECPWRRLQELRELIPNIPFQMLLRGANAVGYTNYPDNVVFKFCEVAKENGMDVFRVF
DSLNYLPNMLLGMEAAGSAGGVVEAAISYTGDVADPSRTKYSLQYYMGLAEELVRAGTHILCIKDMAGLLKPTACTMLVSSLRDRFPDLP
LHIHTHDTSGAGVAAMLACAQAGADVVDVAADSMSGMTSQPSMGALVACTRGTPLDTEVPMERVFDYSEYWEGARGLYAAFDCTATMKSG
NSDVYENEIPGGQYTNLHFQAHSMGLGSKFKEVKKAYVEANQMLGDLIKVTPSSKIVGDLAQFMVQNGLSRAEAEAQAEELSFPRSVVEF
LQGYIGVPHGGFPEPFRSKVLKDLPRVEGRPGASLPPLDLQALEKELVDRHGEEVTPEDVLSAAMYPDVFAHFKDFTATFGPLDSLNTRL
FLQGPKIAEEFEVELERGKTLHIKALAVSDLNRAGQRQVFFELNGQLRSILVKDTQAMKEMHFHPKALKDVKGQIGAPMPGKVIDIKVVA

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Fusion Gene PPI Analysis for ACER3-PC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACER3-PC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACER3-PC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACER3C4540358LEUKODYSTROPHY, PROGRESSIVE, EARLY CHILDHOOD-ONSET2ORPHANET;UNIPROT
HgeneACER3C0025202melanoma1CTD_human
TgenePCC0034341Pyruvate Carboxylase Deficiency Disease2CTD_human;GENOMICS_ENGLAND
TgenePCC0005586Bipolar Disorder1CTD_human
TgenePCC0005587Depression, Bipolar1CTD_human
TgenePCC0006413Burkitt Lymphoma1CTD_human
TgenePCC0019193Hepatitis, Toxic1CTD_human
TgenePCC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePCC0024713Manic Disorder1CTD_human
TgenePCC0338831Manic1CTD_human
TgenePCC0343640African Burkitt's lymphoma1CTD_human
TgenePCC0860207Drug-Induced Liver Disease1CTD_human
TgenePCC1262760Hepatitis, Drug-Induced1CTD_human
TgenePCC3658290Drug-Induced Acute Liver Injury1CTD_human
TgenePCC4277682Chemical and Drug Induced Liver Injury1CTD_human
TgenePCC4279912Chemically-Induced Liver Toxicity1CTD_human
TgenePCC4721444Burkitt Leukemia1CTD_human