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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACHE-CCDC132 (FusionGDB2 ID:1426)

Fusion Gene Summary for ACHE-CCDC132

check button Fusion gene summary
Fusion gene informationFusion gene name: ACHE-CCDC132
Fusion gene ID: 1426
HgeneTgene
Gene symbol

ACHE

CCDC132

Gene ID

43

55610

Gene nameacetylcholinesterase (Cartwright blood group)VPS50 subunit of EARP/GARPII complex
SynonymsACEE|ARACHE|N-ACHE|YTCCDC132|VPS54L
Cytomap

7q22.1

7q21.2-q21.3

Type of geneprotein-codingprotein-coding
DescriptionacetylcholinesteraseYt blood groupacetylcholinesterase (Yt blood group)apoptosis-related acetylcholinesterasesyndetinEARP/GARPII complex subunit VPS50VPS50, EARP/GARPII complex subunitcoiled-coil domain containing 132coiled-coil domain-containing protein 132
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000419336, ENST00000241069, 
ENST00000428317, ENST00000302913, 
ENST00000412389, ENST00000411582, 
ENST00000497647, 		ENST00000305866, 
ENST00000541136, ENST00000544910, 
ENST00000535481, ENST00000317751, 
ENST00000251739, ENST00000474412, 
Fusion gene scores* DoF score2 X 2 X 2=88 X 9 X 6=432
# samples 210
** MAII scorelog2(2/8*10)=1.32192809488736log2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACHE [Title/Abstract] AND CCDC132 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACHE(100490786)-CCDC132(92963429), # samples:1
Anticipated loss of major functional domain due to fusion event.ACHE-CCDC132 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ACHE-CCDC132 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACHE-CCDC132 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACHE

GO:0006581

acetylcholine catabolic process

1517212

HgeneACHE

GO:0007155

cell adhesion

15454088

TgeneCCDC132

GO:0032456

endocytic recycling

25799061


check buttonFusion gene breakpoints across ACHE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCDC132 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-12-0616-01AACHEchr7

100490786

-CCDC132chr7

92963429

+


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Fusion Gene ORF analysis for ACHE-CCDC132

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000419336ENST00000305866ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000419336ENST00000541136ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000419336ENST00000544910ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000419336ENST00000535481ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-intronENST00000419336ENST00000317751ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-intronENST00000419336ENST00000251739ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-3UTRENST00000419336ENST00000474412ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000241069ENST00000305866ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000241069ENST00000541136ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000241069ENST00000544910ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000241069ENST00000535481ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-intronENST00000241069ENST00000317751ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-intronENST00000241069ENST00000251739ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-3UTRENST00000241069ENST00000474412ACHEchr7

100490786

-CCDC132chr7

92963429

+
In-frameENST00000428317ENST00000305866ACHEchr7

100490786

-CCDC132chr7

92963429

+
In-frameENST00000428317ENST00000541136ACHEchr7

100490786

-CCDC132chr7

92963429

+
In-frameENST00000428317ENST00000544910ACHEchr7

100490786

-CCDC132chr7

92963429

+
In-frameENST00000428317ENST00000535481ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-intronENST00000428317ENST00000317751ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-intronENST00000428317ENST00000251739ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-3UTRENST00000428317ENST00000474412ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000302913ENST00000305866ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000302913ENST00000541136ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000302913ENST00000544910ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000302913ENST00000535481ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-intronENST00000302913ENST00000317751ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-intronENST00000302913ENST00000251739ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-3UTRENST00000302913ENST00000474412ACHEchr7

100490786

-CCDC132chr7

92963429

+
In-frameENST00000412389ENST00000305866ACHEchr7

100490786

-CCDC132chr7

92963429

+
In-frameENST00000412389ENST00000541136ACHEchr7

100490786

-CCDC132chr7

92963429

+
In-frameENST00000412389ENST00000544910ACHEchr7

100490786

-CCDC132chr7

92963429

+
In-frameENST00000412389ENST00000535481ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-intronENST00000412389ENST00000317751ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-intronENST00000412389ENST00000251739ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-3UTRENST00000412389ENST00000474412ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000411582ENST00000305866ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000411582ENST00000541136ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000411582ENST00000544910ACHEchr7

100490786

-CCDC132chr7

92963429

+
Frame-shiftENST00000411582ENST00000535481ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-intronENST00000411582ENST00000317751ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-intronENST00000411582ENST00000251739ACHEchr7

100490786

-CCDC132chr7

92963429

+
5CDS-3UTRENST00000411582ENST00000474412ACHEchr7

100490786

-CCDC132chr7

92963429

+
intron-3CDSENST00000497647ENST00000305866ACHEchr7

100490786

-CCDC132chr7

92963429

+
intron-3CDSENST00000497647ENST00000541136ACHEchr7

100490786

-CCDC132chr7

92963429

+
intron-3CDSENST00000497647ENST00000544910ACHEchr7

100490786

-CCDC132chr7

92963429

+
intron-3CDSENST00000497647ENST00000535481ACHEchr7

100490786

-CCDC132chr7

92963429

+
intron-intronENST00000497647ENST00000317751ACHEchr7

100490786

-CCDC132chr7

92963429

+
intron-intronENST00000497647ENST00000251739ACHEchr7

100490786

-CCDC132chr7

92963429

+
intron-3UTRENST00000497647ENST00000474412ACHEchr7

100490786

-CCDC132chr7

92963429

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000428317ACHEchr7100490786-ENST00000305866CCDC132chr792963429+26701162222079685
ENST00000428317ACHEchr7100490786-ENST00000541136CCDC132chr792963429+26641162221533503
ENST00000428317ACHEchr7100490786-ENST00000544910CCDC132chr792963429+26691162222079685
ENST00000428317ACHEchr7100490786-ENST00000535481CCDC132chr792963429+24211162222079685
ENST00000412389ACHEchr7100490786-ENST00000305866CCDC132chr792963429+27321224362141701
ENST00000412389ACHEchr7100490786-ENST00000541136CCDC132chr792963429+27261224361595519
ENST00000412389ACHEchr7100490786-ENST00000544910CCDC132chr792963429+27311224362141701
ENST00000412389ACHEchr7100490786-ENST00000535481CCDC132chr792963429+24831224362141701

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000428317ENST00000305866ACHEchr7100490786-CCDC132chr792963429+0.0003087360.99969125
ENST00000428317ENST00000541136ACHEchr7100490786-CCDC132chr792963429+0.0009941810.99900585
ENST00000428317ENST00000544910ACHEchr7100490786-CCDC132chr792963429+0.0003112280.99968874
ENST00000428317ENST00000535481ACHEchr7100490786-CCDC132chr792963429+0.0007391060.99926084
ENST00000412389ENST00000305866ACHEchr7100490786-CCDC132chr792963429+0.0004485670.99955136
ENST00000412389ENST00000541136ACHEchr7100490786-CCDC132chr792963429+0.0014611590.99853885
ENST00000412389ENST00000544910ACHEchr7100490786-CCDC132chr792963429+0.00045140.9995486
ENST00000412389ENST00000535481ACHEchr7100490786-CCDC132chr792963429+0.001008070.9989919

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Fusion Genomic Features for ACHE-CCDC132


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACHEchr7100490785-CCDC132chr792963428+0.999312640.000687372
ACHEchr7100490785-CCDC132chr792963428+0.999312640.000687372

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACHE-CCDC132


check button Go to

FGviewer for the breakpoints of chr7:100490786-chr7:92963429

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACHEchr7:100490786chr7:92963429ENST00000241069-25233_234356.0615.0RegionGalanthamine binding
HgeneACHEchr7:100490786chr7:92963429ENST00000302913-25233_234356.0618.0RegionGalanthamine binding
HgeneACHEchr7:100490786chr7:92963429ENST00000411582-25233_234356.0618.0RegionGalanthamine binding
HgeneACHEchr7:100490786chr7:92963429ENST00000412389-14233_234356.0615.0RegionGalanthamine binding
HgeneACHEchr7:100490786chr7:92963429ENST00000419336-25233_234356.0527.0RegionGalanthamine binding
HgeneACHEchr7:100490786chr7:92963429ENST00000428317-25233_234356.0615.0RegionGalanthamine binding
TgeneCCDC132chr7:100490786chr7:92963429ENST00000251739012216_2440328.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr7:100490786chr7:92963429ENST0000025173901282_1050328.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCCDC132chr7:100490786chr7:92963429ENST000003058662028216_244659.0965.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr7:100490786chr7:92963429ENST00000305866202882_105659.0965.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr7:100490786chr7:92963429ENST000005449102129216_244629.0935.0Coiled coilOntology_term=ECO:0000255
TgeneCCDC132chr7:100490786chr7:92963429ENST00000544910212982_105629.0935.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for ACHE-CCDC132


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000428317_ENST00000305866_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(transcript)=2670nt_BP=1162nt
TCTACTCCGCCGCTGCAGGTCTTTGGGTCGCGTCTGTCACTGCGCTCTGTCGTCGGTCGGCGTCTGGCACTGGAACGCCGCCTGCCCTGC
AGCCATGAGGCCCCCGCAGTGTCTGCTGCACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTCCTCCTCTGGCTCCTGGGTGGAGGAGT
GGGGGCTGAGGGCCGGGAGGATGCAGAGCTGCTGGTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCC
TGTCTCTGCTTTCCTGGGCATCCCCTTTGCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCACCGGAGCCCAAGCAGCCTTGGTCAGG
GGTGGTAGACGCTACAACCTTCCAGAGTGTCTGCTACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCC
CAACCGTGAGCTGAGCGAGGACTGCCTGTACCTCAACGTGTGGACACCATACCCCCGGCCTACATCCCCCACCCCTGTCCTCGTCTGGAT
CTATGGGGGTGGCTTCTACAGTGGGGCCTCCTCCTTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTC
CATGAACTACCGGGTGGGAGCCTTTGGCTTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGCAATGTGGGTCTCCTGGATCAGAGGCT
GGCCCTGCAGTGGGTGCAGGAGAACGTGGCAGCCTTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTC
GGTGGGCATGCACCTGCTGTCCCCGCCCAGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGCGGTGCCCCCAATGGACCCTGGGCCAC
GGTGGGCATGGGAGAGGCCCGTCGCAGGGCCACGCAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGA
GCTGGTAGCCTGCCTTCGGACACGACCAGCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTGCCTCAAGAAAGCGTCTTCCGGTTCTC
CTTCGTGCCTGTGGTAGATGGAGACTTCCTCAGTGACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGTTGGAATC
AACTGGACTCGGCCTTAGTAGTAGTAGACTAAGAACAACTCTAAACAGAATACAAGAAAGCCTTATTGATCTAGAAGTTTCAGCTGATCC
TACTGCCACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATAC
GCTGTATGGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGC
TGTGATGCCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAGACAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTG
GATTGTAGCTGGTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCA
CAACATATATGTAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCC
TGTGTCTAATATACTTTGGGAACATTGTATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGA
GGGTCGTGCCCTGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATT
TGTAGAAACTTATATTAAAGCTTATTACCTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCT
GACCAATCTGGTGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGACAGACC
TAAAAGATAATGAACACAGCTCTCTTTCCTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATGCACTTC
TGACAACTATCTGCTAAGAAAACTTTGTGCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATGACTTTT
ATATGCTGTGGTCTCTTCAACTTTTGGTCTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTGACTACA
GTTATACATTTTACAGAAGAATGTACCATAAGTATATAATTAGAAGAACAGTGGCTTAATATATGTATGGGAAGTTTATGGAAAATGAAG
TTGGCACTTTTCTACCCTCTGAGCTTGGTTCTTAATAAGCATAATGTGAGGGTGAATATGTAGTATCTCCTAATTATGAGCACTGCATGA
GAATTAAAAAACACATGTAAGTAAAATAGTTGAAAAATCAGTATGTTCTCTGTTTTTAAAATGTCAAAGTTTATGTCAGGGTTAATTTAG

>In-frame_ENST00000428317_ENST00000305866_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(amino acids)=685AA_start in transcript=22_stop in transcript=2079
MGRVCHCALSSVGVWHWNAACPAAMRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGI
PFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYS
GASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLS
PPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDG
DFLSDTPEALINAGDFHGLQLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAER
VVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDAL
LKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKA

--------------------------------------------------------------
>In-frame_ENST00000428317_ENST00000541136_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(transcript)=2664nt_BP=1162nt
TCTACTCCGCCGCTGCAGGTCTTTGGGTCGCGTCTGTCACTGCGCTCTGTCGTCGGTCGGCGTCTGGCACTGGAACGCCGCCTGCCCTGC
AGCCATGAGGCCCCCGCAGTGTCTGCTGCACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTCCTCCTCTGGCTCCTGGGTGGAGGAGT
GGGGGCTGAGGGCCGGGAGGATGCAGAGCTGCTGGTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCC
TGTCTCTGCTTTCCTGGGCATCCCCTTTGCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCACCGGAGCCCAAGCAGCCTTGGTCAGG
GGTGGTAGACGCTACAACCTTCCAGAGTGTCTGCTACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCC
CAACCGTGAGCTGAGCGAGGACTGCCTGTACCTCAACGTGTGGACACCATACCCCCGGCCTACATCCCCCACCCCTGTCCTCGTCTGGAT
CTATGGGGGTGGCTTCTACAGTGGGGCCTCCTCCTTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTC
CATGAACTACCGGGTGGGAGCCTTTGGCTTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGCAATGTGGGTCTCCTGGATCAGAGGCT
GGCCCTGCAGTGGGTGCAGGAGAACGTGGCAGCCTTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTC
GGTGGGCATGCACCTGCTGTCCCCGCCCAGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGCGGTGCCCCCAATGGACCCTGGGCCAC
GGTGGGCATGGGAGAGGCCCGTCGCAGGGCCACGCAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGA
GCTGGTAGCCTGCCTTCGGACACGACCAGCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTGCCTCAAGAAAGCGTCTTCCGGTTCTC
CTTCGTGCCTGTGGTAGATGGAGACTTCCTCAGTGACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGTTGGAATC
AACTGGACTCGGCCTTAGTAGTAGTAGACTAAGAACAACTCTAAACAGAATACAAGAAAGCCTTATTGATCTAGAAGTTTCAGCTGATCC
TACTGCCACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATAC
GCTGTATGGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGC
TGTGATGCCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTGGATT
GTAGCTGGTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCACAAC
ATATATGTAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCCTGTG
TCTAATATACTTTGGGAACATTGTATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGAGGGT
CGTGCCCTGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATTTGTA
GAAACTTATATTAAAGCTTATTACCTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCTGACC
AATCTGGTGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGACAGACCTAAA
AGATAATGAACACAGCTCTCTTTCCTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATGCACTTCTGAC
AACTATCTGCTAAGAAAACTTTGTGCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATGACTTTTATAT
GCTGTGGTCTCTTCAACTTTTGGTCTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTGACTACAGTTA
TACATTTTACAGAAGAATGTACCATAAGTATATAATTAGAAGAACAGTGGCTTAATATATGTATGGGAAGTTTATGGAAAATGAAGTTGG
CACTTTTCTACCCTCTGAGCTTGGTTCTTAATAAGCATAATGTGAGGGTGAATATGTAGTATCTCCTAATTATGAGCACTGCATGAGAAT
TAAAAAACACATGTAAGTAAAATAGTTGAAAAATCAGTATGTTCTCTGTTTTTAAAATGTCAAAGTTTATGTCAGGGTTAATTTAGTTAT

>In-frame_ENST00000428317_ENST00000541136_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(amino acids)=503AA_start in transcript=22_stop in transcript=1533
MGRVCHCALSSVGVWHWNAACPAAMRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGI
PFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYS
GASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLS
PPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDG
DFLSDTPEALINAGDFHGLQLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAER

--------------------------------------------------------------
>In-frame_ENST00000428317_ENST00000544910_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(transcript)=2669nt_BP=1162nt
TCTACTCCGCCGCTGCAGGTCTTTGGGTCGCGTCTGTCACTGCGCTCTGTCGTCGGTCGGCGTCTGGCACTGGAACGCCGCCTGCCCTGC
AGCCATGAGGCCCCCGCAGTGTCTGCTGCACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTCCTCCTCTGGCTCCTGGGTGGAGGAGT
GGGGGCTGAGGGCCGGGAGGATGCAGAGCTGCTGGTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCC
TGTCTCTGCTTTCCTGGGCATCCCCTTTGCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCACCGGAGCCCAAGCAGCCTTGGTCAGG
GGTGGTAGACGCTACAACCTTCCAGAGTGTCTGCTACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCC
CAACCGTGAGCTGAGCGAGGACTGCCTGTACCTCAACGTGTGGACACCATACCCCCGGCCTACATCCCCCACCCCTGTCCTCGTCTGGAT
CTATGGGGGTGGCTTCTACAGTGGGGCCTCCTCCTTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTC
CATGAACTACCGGGTGGGAGCCTTTGGCTTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGCAATGTGGGTCTCCTGGATCAGAGGCT
GGCCCTGCAGTGGGTGCAGGAGAACGTGGCAGCCTTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTC
GGTGGGCATGCACCTGCTGTCCCCGCCCAGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGCGGTGCCCCCAATGGACCCTGGGCCAC
GGTGGGCATGGGAGAGGCCCGTCGCAGGGCCACGCAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGA
GCTGGTAGCCTGCCTTCGGACACGACCAGCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTGCCTCAAGAAAGCGTCTTCCGGTTCTC
CTTCGTGCCTGTGGTAGATGGAGACTTCCTCAGTGACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGTTGGAATC
AACTGGACTCGGCCTTAGTAGTAGTAGACTAAGAACAACTCTAAACAGAATACAAGAAAGCCTTATTGATCTAGAAGTTTCAGCTGATCC
TACTGCCACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATAC
GCTGTATGGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGC
TGTGATGCCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAGACAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTG
GATTGTAGCTGGTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCA
CAACATATATGTAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCC
TGTGTCTAATATACTTTGGGAACATTGTATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGA
GGGTCGTGCCCTGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATT
TGTAGAAACTTATATTAAAGCTTATTACCTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCT
GACCAATCTGGTGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGACAGACC
TAAAAGATAATGAACACAGCTCTCTTTCCTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATGCACTTC
TGACAACTATCTGCTAAGAAAACTTTGTGCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATGACTTTT
ATATGCTGTGGTCTCTTCAACTTTTGGTCTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTGACTACA
GTTATACATTTTACAGAAGAATGTACCATAAGTATATAATTAGAAGAACAGTGGCTTAATATATGTATGGGAAGTTTATGGAAAATGAAG
TTGGCACTTTTCTACCCTCTGAGCTTGGTTCTTAATAAGCATAATGTGAGGGTGAATATGTAGTATCTCCTAATTATGAGCACTGCATGA
GAATTAAAAAACACATGTAAGTAAAATAGTTGAAAAATCAGTATGTTCTCTGTTTTTAAAATGTCAAAGTTTATGTCAGGGTTAATTTAG

>In-frame_ENST00000428317_ENST00000544910_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(amino acids)=685AA_start in transcript=22_stop in transcript=2079
MGRVCHCALSSVGVWHWNAACPAAMRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGI
PFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYS
GASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLS
PPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDG
DFLSDTPEALINAGDFHGLQLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAER
VVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDAL
LKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKA

--------------------------------------------------------------
>In-frame_ENST00000428317_ENST00000535481_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(transcript)=2421nt_BP=1162nt
TCTACTCCGCCGCTGCAGGTCTTTGGGTCGCGTCTGTCACTGCGCTCTGTCGTCGGTCGGCGTCTGGCACTGGAACGCCGCCTGCCCTGC
AGCCATGAGGCCCCCGCAGTGTCTGCTGCACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTCCTCCTCTGGCTCCTGGGTGGAGGAGT
GGGGGCTGAGGGCCGGGAGGATGCAGAGCTGCTGGTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCC
TGTCTCTGCTTTCCTGGGCATCCCCTTTGCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCACCGGAGCCCAAGCAGCCTTGGTCAGG
GGTGGTAGACGCTACAACCTTCCAGAGTGTCTGCTACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCC
CAACCGTGAGCTGAGCGAGGACTGCCTGTACCTCAACGTGTGGACACCATACCCCCGGCCTACATCCCCCACCCCTGTCCTCGTCTGGAT
CTATGGGGGTGGCTTCTACAGTGGGGCCTCCTCCTTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTC
CATGAACTACCGGGTGGGAGCCTTTGGCTTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGCAATGTGGGTCTCCTGGATCAGAGGCT
GGCCCTGCAGTGGGTGCAGGAGAACGTGGCAGCCTTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTC
GGTGGGCATGCACCTGCTGTCCCCGCCCAGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGCGGTGCCCCCAATGGACCCTGGGCCAC
GGTGGGCATGGGAGAGGCCCGTCGCAGGGCCACGCAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGA
GCTGGTAGCCTGCCTTCGGACACGACCAGCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTGCCTCAAGAAAGCGTCTTCCGGTTCTC
CTTCGTGCCTGTGGTAGATGGAGACTTCCTCAGTGACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGTTGGAATC
AACTGGACTCGGCCTTAGTAGTAGTAGACTAAGAACAACTCTAAACAGAATACAAGAAAGCCTTATTGATCTAGAAGTTTCAGCTGATCC
TACTGCCACACTCACAGCAGCAGAAGAAAGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATAC
GCTGTATGGGTTGGCAGAAAGAGTGGTAGCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGC
TGTGATGCCTGCAGTCAAAAAGCCCTTTCTTCAGCAGTTCTATTCTCAGACAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTG
GATTGTAGCTGGTAAAGCCCTTGATTATGAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCA
CAACATATATGTAGATGCACTATTAAAGGAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCC
TGTGTCTAATATACTTTGGGAACATTGTATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGA
GGGTCGTGCCCTGATGCAATTGGATTTTCAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATT
TGTAGAAACTTATATTAAAGCTTATTACCTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCT
GACCAATCTGGTGAATGTTTGCCTGGGATCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGACAGACC
TAAAAGATAATGAACACAGCTCTCTTTCCTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATGCACTTC
TGACAACTATCTGCTAAGAAAACTTTGTGCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATGACTTTT
ATATGCTGTGGTCTCTTCAACTTTTGGTCTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTGACTACA

>In-frame_ENST00000428317_ENST00000535481_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(amino acids)=685AA_start in transcript=22_stop in transcript=2079
MGRVCHCALSSVGVWHWNAACPAAMRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGI
PFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYS
GASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLS
PPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDG
DFLSDTPEALINAGDFHGLQLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSHLVVLTSGDTLYGLAER
VVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKWDVKEIMSQHNIYVDAL
LKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTDIRPIPDKEFVETYIKA

--------------------------------------------------------------
>In-frame_ENST00000412389_ENST00000305866_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(transcript)=2732nt_BP=1224nt
CTCTCCCCTCATCTTTGCCAACCTGCCCCACCTCCTCTGCAGCTGAGCGATAACCCTTGGGCCGACAGTGCCCTAATCTCCTCCCTCCTG
GCTTCTCGACCGACCCTTCACCCTTTCCCTTTCTTTCTCCCAGCAGACGCCGCCTGCCCTGCAGCCATGAGGCCCCCGCAGTGTCTGCTG
CACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTCCTCCTCTGGCTCCTGGGTGGAGGAGTGGGGGCTGAGGGCCGGGAGGATGCAGAG
CTGCTGGTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCCTGTCTCTGCTTTCCTGGGCATCCCCTTT
GCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCACCGGAGCCCAAGCAGCCTTGGTCAGGGGTGGTAGACGCTACAACCTTCCAGAGT
GTCTGCTACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCCCAACCGTGAGCTGAGCGAGGACTGCCTG
TACCTCAACGTGTGGACACCATACCCCCGGCCTACATCCCCCACCCCTGTCCTCGTCTGGATCTATGGGGGTGGCTTCTACAGTGGGGCC
TCCTCCTTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTCCATGAACTACCGGGTGGGAGCCTTTGGC
TTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGCAATGTGGGTCTCCTGGATCAGAGGCTGGCCCTGCAGTGGGTGCAGGAGAACGTG
GCAGCCTTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTCGGTGGGCATGCACCTGCTGTCCCCGCCC
AGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGCGGTGCCCCCAATGGACCCTGGGCCACGGTGGGCATGGGAGAGGCCCGTCGCAGG
GCCACGCAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGAGCTGGTAGCCTGCCTTCGGACACGACCA
GCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTGCCTCAAGAAAGCGTCTTCCGGTTCTCCTTCGTGCCTGTGGTAGATGGAGACTTC
CTCAGTGACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGTTGGAATCAACTGGACTCGGCCTTAGTAGTAGTAGA
CTAAGAACAACTCTAAACAGAATACAAGAAAGCCTTATTGATCTAGAAGTTTCAGCTGATCCTACTGCCACACTCACAGCAGCAGAAGAA
AGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATACGCTGTATGGGTTGGCAGAAAGAGTGGTA
GCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGCTGTGATGCCTGCAGTCAAAAAGCCCTTT
CTTCAGCAGTTCTATTCTCAGACAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTGGATTGTAGCTGGTAAAGCCCTTGATTAT
GAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCACAACATATATGTAGATGCACTATTAAAG
GAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCCTGTGTCTAATATACTTTGGGAACATTGT
ATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGAGGGTCGTGCCCTGATGCAATTGGATTTT
CAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATTTGTAGAAACTTATATTAAAGCTTATTAC
CTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCTGACCAATCTGGTGAATGTTTGCCTGGGA
TCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGACAGACCTAAAAGATAATGAACACAGCTCTCTTTC
CTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATGCACTTCTGACAACTATCTGCTAAGAAAACTTTGT
GCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATGACTTTTATATGCTGTGGTCTCTTCAACTTTTGGT
CTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTGACTACAGTTATACATTTTACAGAAGAATGTACCA
TAAGTATATAATTAGAAGAACAGTGGCTTAATATATGTATGGGAAGTTTATGGAAAATGAAGTTGGCACTTTTCTACCCTCTGAGCTTGG
TTCTTAATAAGCATAATGTGAGGGTGAATATGTAGTATCTCCTAATTATGAGCACTGCATGAGAATTAAAAAACACATGTAAGTAAAATA
GTTGAAAAATCAGTATGTTCTCTGTTTTTAAAATGTCAAAGTTTATGTCAGGGTTAATTTAGTTATAACAAAGTGATCATAATGGTGAAA

>In-frame_ENST00000412389_ENST00000305866_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(amino acids)=701AA_start in transcript=36_stop in transcript=2141
MQLSDNPWADSALISSLLASRPTLHPFPFFLPADAACPAAMRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRG
IRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPT
SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTL
FGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVL
PQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSH
LVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKW
DVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTD

--------------------------------------------------------------
>In-frame_ENST00000412389_ENST00000541136_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(transcript)=2726nt_BP=1224nt
CTCTCCCCTCATCTTTGCCAACCTGCCCCACCTCCTCTGCAGCTGAGCGATAACCCTTGGGCCGACAGTGCCCTAATCTCCTCCCTCCTG
GCTTCTCGACCGACCCTTCACCCTTTCCCTTTCTTTCTCCCAGCAGACGCCGCCTGCCCTGCAGCCATGAGGCCCCCGCAGTGTCTGCTG
CACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTCCTCCTCTGGCTCCTGGGTGGAGGAGTGGGGGCTGAGGGCCGGGAGGATGCAGAG
CTGCTGGTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCCTGTCTCTGCTTTCCTGGGCATCCCCTTT
GCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCACCGGAGCCCAAGCAGCCTTGGTCAGGGGTGGTAGACGCTACAACCTTCCAGAGT
GTCTGCTACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCCCAACCGTGAGCTGAGCGAGGACTGCCTG
TACCTCAACGTGTGGACACCATACCCCCGGCCTACATCCCCCACCCCTGTCCTCGTCTGGATCTATGGGGGTGGCTTCTACAGTGGGGCC
TCCTCCTTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTCCATGAACTACCGGGTGGGAGCCTTTGGC
TTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGCAATGTGGGTCTCCTGGATCAGAGGCTGGCCCTGCAGTGGGTGCAGGAGAACGTG
GCAGCCTTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTCGGTGGGCATGCACCTGCTGTCCCCGCCC
AGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGCGGTGCCCCCAATGGACCCTGGGCCACGGTGGGCATGGGAGAGGCCCGTCGCAGG
GCCACGCAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGAGCTGGTAGCCTGCCTTCGGACACGACCA
GCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTGCCTCAAGAAAGCGTCTTCCGGTTCTCCTTCGTGCCTGTGGTAGATGGAGACTTC
CTCAGTGACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGTTGGAATCAACTGGACTCGGCCTTAGTAGTAGTAGA
CTAAGAACAACTCTAAACAGAATACAAGAAAGCCTTATTGATCTAGAAGTTTCAGCTGATCCTACTGCCACACTCACAGCAGCAGAAGAA
AGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATACGCTGTATGGGTTGGCAGAAAGAGTGGTA
GCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGCTGTGATGCCTGCAGTCAAAAAGCCCTTT
CTTCAGCAGTTCTATTCTCAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTGGATTGTAGCTGGTAAAGCCCTTGATTATGAAC
AGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCACAACATATATGTAGATGCACTATTAAAGGAAT
TTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCCTGTGTCTAATATACTTTGGGAACATTGTATAC
GATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGAGGGTCGTGCCCTGATGCAATTGGATTTTCAAC
AGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATTTGTAGAAACTTATATTAAAGCTTATTACCTAA
CTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCTGACCAATCTGGTGAATGTTTGCCTGGGATCCC
ATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGACAGACCTAAAAGATAATGAACACAGCTCTCTTTCCTCA
ATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATGCACTTCTGACAACTATCTGCTAAGAAAACTTTGTGCAT
GTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATGACTTTTATATGCTGTGGTCTCTTCAACTTTTGGTCTCA
TTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTGACTACAGTTATACATTTTACAGAAGAATGTACCATAAG
TATATAATTAGAAGAACAGTGGCTTAATATATGTATGGGAAGTTTATGGAAAATGAAGTTGGCACTTTTCTACCCTCTGAGCTTGGTTCT
TAATAAGCATAATGTGAGGGTGAATATGTAGTATCTCCTAATTATGAGCACTGCATGAGAATTAAAAAACACATGTAAGTAAAATAGTTG
AAAAATCAGTATGTTCTCTGTTTTTAAAATGTCAAAGTTTATGTCAGGGTTAATTTAGTTATAACAAAGTGATCATAATGGTGAAATTTA

>In-frame_ENST00000412389_ENST00000541136_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(amino acids)=519AA_start in transcript=36_stop in transcript=1595
MQLSDNPWADSALISSLLASRPTLHPFPFFLPADAACPAAMRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRG
IRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPT
SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTL
FGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVL
PQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSH

--------------------------------------------------------------
>In-frame_ENST00000412389_ENST00000544910_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(transcript)=2731nt_BP=1224nt
CTCTCCCCTCATCTTTGCCAACCTGCCCCACCTCCTCTGCAGCTGAGCGATAACCCTTGGGCCGACAGTGCCCTAATCTCCTCCCTCCTG
GCTTCTCGACCGACCCTTCACCCTTTCCCTTTCTTTCTCCCAGCAGACGCCGCCTGCCCTGCAGCCATGAGGCCCCCGCAGTGTCTGCTG
CACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTCCTCCTCTGGCTCCTGGGTGGAGGAGTGGGGGCTGAGGGCCGGGAGGATGCAGAG
CTGCTGGTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCCTGTCTCTGCTTTCCTGGGCATCCCCTTT
GCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCACCGGAGCCCAAGCAGCCTTGGTCAGGGGTGGTAGACGCTACAACCTTCCAGAGT
GTCTGCTACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCCCAACCGTGAGCTGAGCGAGGACTGCCTG
TACCTCAACGTGTGGACACCATACCCCCGGCCTACATCCCCCACCCCTGTCCTCGTCTGGATCTATGGGGGTGGCTTCTACAGTGGGGCC
TCCTCCTTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTCCATGAACTACCGGGTGGGAGCCTTTGGC
TTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGCAATGTGGGTCTCCTGGATCAGAGGCTGGCCCTGCAGTGGGTGCAGGAGAACGTG
GCAGCCTTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTCGGTGGGCATGCACCTGCTGTCCCCGCCC
AGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGCGGTGCCCCCAATGGACCCTGGGCCACGGTGGGCATGGGAGAGGCCCGTCGCAGG
GCCACGCAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGAGCTGGTAGCCTGCCTTCGGACACGACCA
GCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTGCCTCAAGAAAGCGTCTTCCGGTTCTCCTTCGTGCCTGTGGTAGATGGAGACTTC
CTCAGTGACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGTTGGAATCAACTGGACTCGGCCTTAGTAGTAGTAGA
CTAAGAACAACTCTAAACAGAATACAAGAAAGCCTTATTGATCTAGAAGTTTCAGCTGATCCTACTGCCACACTCACAGCAGCAGAAGAA
AGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATACGCTGTATGGGTTGGCAGAAAGAGTGGTA
GCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGCTGTGATGCCTGCAGTCAAAAAGCCCTTT
CTTCAGCAGTTCTATTCTCAGACAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTGGATTGTAGCTGGTAAAGCCCTTGATTAT
GAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCACAACATATATGTAGATGCACTATTAAAG
GAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCCTGTGTCTAATATACTTTGGGAACATTGT
ATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGAGGGTCGTGCCCTGATGCAATTGGATTTT
CAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATTTGTAGAAACTTATATTAAAGCTTATTAC
CTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCTGACCAATCTGGTGAATGTTTGCCTGGGA
TCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGACAGACCTAAAAGATAATGAACACAGCTCTCTTTC
CTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATGCACTTCTGACAACTATCTGCTAAGAAAACTTTGT
GCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATGACTTTTATATGCTGTGGTCTCTTCAACTTTTGGT
CTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTGACTACAGTTATACATTTTACAGAAGAATGTACCA
TAAGTATATAATTAGAAGAACAGTGGCTTAATATATGTATGGGAAGTTTATGGAAAATGAAGTTGGCACTTTTCTACCCTCTGAGCTTGG
TTCTTAATAAGCATAATGTGAGGGTGAATATGTAGTATCTCCTAATTATGAGCACTGCATGAGAATTAAAAAACACATGTAAGTAAAATA
GTTGAAAAATCAGTATGTTCTCTGTTTTTAAAATGTCAAAGTTTATGTCAGGGTTAATTTAGTTATAACAAAGTGATCATAATGGTGAAA

>In-frame_ENST00000412389_ENST00000544910_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(amino acids)=701AA_start in transcript=36_stop in transcript=2141
MQLSDNPWADSALISSLLASRPTLHPFPFFLPADAACPAAMRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRG
IRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPT
SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTL
FGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVL
PQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSH
LVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKW
DVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTD

--------------------------------------------------------------
>In-frame_ENST00000412389_ENST00000535481_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(transcript)=2483nt_BP=1224nt
CTCTCCCCTCATCTTTGCCAACCTGCCCCACCTCCTCTGCAGCTGAGCGATAACCCTTGGGCCGACAGTGCCCTAATCTCCTCCCTCCTG
GCTTCTCGACCGACCCTTCACCCTTTCCCTTTCTTTCTCCCAGCAGACGCCGCCTGCCCTGCAGCCATGAGGCCCCCGCAGTGTCTGCTG
CACACGCCTTCCCTGGCTTCCCCACTCCTTCTCCTCCTCCTCTGGCTCCTGGGTGGAGGAGTGGGGGCTGAGGGCCGGGAGGATGCAGAG
CTGCTGGTGACGGTGCGTGGGGGCCGGCTGCGGGGCATTCGCCTGAAGACCCCCGGGGGCCCTGTCTCTGCTTTCCTGGGCATCCCCTTT
GCGGAGCCACCCATGGGACCCCGTCGCTTTCTGCCACCGGAGCCCAAGCAGCCTTGGTCAGGGGTGGTAGACGCTACAACCTTCCAGAGT
GTCTGCTACCAATATGTGGACACCCTATACCCAGGTTTTGAGGGCACCGAGATGTGGAACCCCAACCGTGAGCTGAGCGAGGACTGCCTG
TACCTCAACGTGTGGACACCATACCCCCGGCCTACATCCCCCACCCCTGTCCTCGTCTGGATCTATGGGGGTGGCTTCTACAGTGGGGCC
TCCTCCTTGGACGTGTACGATGGCCGCTTCTTGGTACAGGCCGAGAGGACTGTGCTGGTGTCCATGAACTACCGGGTGGGAGCCTTTGGC
TTCCTGGCCCTGCCGGGGAGCCGAGAGGCCCCGGGCAATGTGGGTCTCCTGGATCAGAGGCTGGCCCTGCAGTGGGTGCAGGAGAACGTG
GCAGCCTTCGGGGGTGACCCGACATCAGTGACGCTGTTTGGGGAGAGCGCGGGAGCCGCCTCGGTGGGCATGCACCTGCTGTCCCCGCCC
AGCCGGGGCCTGTTCCACAGGGCCGTGCTGCAGAGCGGTGCCCCCAATGGACCCTGGGCCACGGTGGGCATGGGAGAGGCCCGTCGCAGG
GCCACGCAGCTGGCCCACCTTGTGGGCTGTCCTCCAGGCGGCACTGGTGGGAATGACACAGAGCTGGTAGCCTGCCTTCGGACACGACCA
GCGCAGGTCCTGGTGAACCACGAATGGCACGTGCTGCCTCAAGAAAGCGTCTTCCGGTTCTCCTTCGTGCCTGTGGTAGATGGAGACTTC
CTCAGTGACACCCCAGAGGCCCTCATCAACGCGGGAGACTTCCACGGCCTGCAGTTGGAATCAACTGGACTCGGCCTTAGTAGTAGTAGA
CTAAGAACAACTCTAAACAGAATACAAGAAAGCCTTATTGATCTAGAAGTTTCAGCTGATCCTACTGCCACACTCACAGCAGCAGAAGAA
AGAAAGGAGAAGGTGCCAAGTCCACACCTCAGTCACCTAGTGGTTTTGACATCTGGGGATACGCTGTATGGGTTGGCAGAAAGAGTGGTA
GCCACGGAATCCTTGGTATTCTTGGCTGAACAGTTTGAGTTCCTTCAGCCACATCTGGATGCTGTGATGCCTGCAGTCAAAAAGCCCTTT
CTTCAGCAGTTCTATTCTCAGACAGTCTCAACCGCCAGTGAACTACGGAAACCAATTTACTGGATTGTAGCTGGTAAAGCCCTTGATTAT
GAACAGATGCTGCTTCTCATGGCTAATGTGAAATGGGATGTAAAAGAAATTATGTCACAGCACAACATATATGTAGATGCACTATTAAAG
GAATTTGAGCAGTTTAACAGGAGGCTAAATGAAGTTTCTAAGAGAGTTCGCATACCCTTGCCTGTGTCTAATATACTTTGGGAACATTGT
ATACGATTGGCTAATCGAACTATTGTAGAAGGATATGCCAATGTCAAGAAATGCAGTAATGAGGGTCGTGCCCTGATGCAATTGGATTTT
CAACAGTTTTTAATGAAACTTGAAAAACTAACAGATATTAGACCCATTCCTGATAAAGAATTTGTAGAAACTTATATTAAAGCTTATTAC
CTAACTGAGAATGACATGGAACGGTGGATCAAAGAGCACAGGGAATATTCAACGAAGCAGCTGACCAATCTGGTGAATGTTTGCCTGGGA
TCCCATATCAATAAGAAAGCAAGACAAAAACTTCTAGCAGCTATAGATGATATAGACAGACCTAAAAGATAATGAACACAGCTCTCTTTC
CTCAATGGCATTGATCCTCACTCAACATATATGACCTGAAAGCCAGTTTTTTTATGCACTTCTGACAACTATCTGCTAAGAAAACTTTGT
GCATGTTTTTTTGACTGGAAAGTGGAAAATATTGAAATGTGTGTGGTGTTCTCATGACTTTTATATGCTGTGGTCTCTTCAACTTTTGGT
CTCATTTGTTGTAATCTGAAATGATGTTGCCGCCTTGTCATAACAATGGTTATGTGACTACAGTTATACATTTTACAGAAGAATGTACCA

>In-frame_ENST00000412389_ENST00000535481_TCGA-12-0616-01A_ACHE_chr7_100490786_-_CCDC132_chr7_92963429_length(amino acids)=701AA_start in transcript=36_stop in transcript=2141
MQLSDNPWADSALISSLLASRPTLHPFPFFLPADAACPAAMRPPQCLLHTPSLASPLLLLLLWLLGGGVGAEGREDAELLVTVRGGRLRG
IRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPT
SPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTL
FGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVL
PQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQLESTGLGLSSSRLRTTLNRIQESLIDLEVSADPTATLTAAEERKEKVPSPHLSH
LVVLTSGDTLYGLAERVVATESLVFLAEQFEFLQPHLDAVMPAVKKPFLQQFYSQTVSTASELRKPIYWIVAGKALDYEQMLLLMANVKW
DVKEIMSQHNIYVDALLKEFEQFNRRLNEVSKRVRIPLPVSNILWEHCIRLANRTIVEGYANVKKCSNEGRALMQLDFQQFLMKLEKLTD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACHE-CCDC132


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACHE-CCDC132


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACHE-CCDC132


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneACHEC0353676Organophosphorus Poisoning3CTD_human
HgeneACHEC0700359Organophosphate poisoning3CTD_human
HgeneACHEC3494247Organothiophosphonate Poisoning3CTD_human
HgeneACHEC3494248Organothiophosphate Poisoning3CTD_human
HgeneACHEC0002395Alzheimer's Disease2CTD_human
HgeneACHEC0011265Presenile dementia2CTD_human
HgeneACHEC0022333Jacksonian Seizure2CTD_human
HgeneACHEC0036572Seizures2CTD_human
HgeneACHEC0149958Complex partial seizures2CTD_human
HgeneACHEC0234533Generalized seizures2CTD_human
HgeneACHEC0234535Clonic Seizures2CTD_human
HgeneACHEC0270824Visual seizure2CTD_human
HgeneACHEC0270844Tonic Seizures2CTD_human
HgeneACHEC0270846Epileptic drop attack2CTD_human
HgeneACHEC0276496Familial Alzheimer Disease (FAD)2CTD_human
HgeneACHEC0422850Seizures, Somatosensory2CTD_human
HgeneACHEC0422852Seizures, Auditory2CTD_human
HgeneACHEC0422853Olfactory seizure2CTD_human
HgeneACHEC0422854Gustatory seizure2CTD_human
HgeneACHEC0422855Vertiginous seizure2CTD_human
HgeneACHEC0494463Alzheimer Disease, Late Onset2CTD_human
HgeneACHEC0494475Tonic - clonic seizures2CTD_human
HgeneACHEC0546126Acute Confusional Senile Dementia2CTD_human
HgeneACHEC0750900Alzheimer's Disease, Focal Onset2CTD_human
HgeneACHEC0750901Alzheimer Disease, Early Onset2CTD_human
HgeneACHEC0751056Non-epileptic convulsion2CTD_human
HgeneACHEC0751110Single Seizure2CTD_human
HgeneACHEC0751123Atonic Absence Seizures2CTD_human
HgeneACHEC0751494Convulsive Seizures2CTD_human
HgeneACHEC0751495Seizures, Focal2CTD_human
HgeneACHEC0751496Seizures, Sensory2CTD_human
HgeneACHEC3495874Nonepileptic Seizures2CTD_human
HgeneACHEC4048158Convulsions2CTD_human
HgeneACHEC4316903Absence Seizures2CTD_human
HgeneACHEC4317109Epileptic Seizures2CTD_human
HgeneACHEC4317123Myoclonic Seizures2CTD_human
HgeneACHEC4505436Generalized Absence Seizures2CTD_human
HgeneACHEC0002726Amyloidosis1CTD_human
HgeneACHEC0002871Anemia1CTD_human
HgeneACHEC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneACHEC0005695Bladder Neoplasm1CTD_human
HgeneACHEC0006142Malignant neoplasm of breast1CTD_human
HgeneACHEC0007134Renal Cell Carcinoma1CTD_human
HgeneACHEC0013221Drug toxicity1CTD_human
HgeneACHEC0018273Growth Disorders1CTD_human
HgeneACHEC0023186Learning Disorders1CTD_human
HgeneACHEC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneACHEC0025261Memory Disorders1CTD_human
HgeneACHEC0026650Movement Disorders1CTD_human
HgeneACHEC0026850Muscular Dystrophy1CTD_human
HgeneACHEC0027765nervous system disorder1CTD_human
HgeneACHEC0028754Obesity1CTD_human
HgeneACHEC0033578Prostatic Neoplasms1CTD_human
HgeneACHEC0036341Schizophrenia1PSYGENET
HgeneACHEC0040822Tremor1CTD_human
HgeneACHEC0040827Saturnine Tremor1CTD_human
HgeneACHEC0041755Adverse reaction to drug1CTD_human
HgeneACHEC0149840Senile Tremor1CTD_human
HgeneACHEC0233794Memory impairment1CTD_human
HgeneACHEC0234370Persistent Tremor1CTD_human
HgeneACHEC0234371Continuous Tremor1CTD_human
HgeneACHEC0234372Intermittent Tremor1CTD_human
HgeneACHEC0234373Fine Tremor1CTD_human
HgeneACHEC0234374Coarse Tremor1CTD_human
HgeneACHEC0234375Massive Tremor1CTD_human
HgeneACHEC0234376Action Tremor1CTD_human
HgeneACHEC0234377Passive Tremor1CTD_human
HgeneACHEC0234378Static Tremor1CTD_human
HgeneACHEC0234379Resting Tremor1CTD_human
HgeneACHEC0234381Darkness Tremor1CTD_human
HgeneACHEC0235078Tremor, Perioral1CTD_human
HgeneACHEC0235081Tremor, Limb1CTD_human
HgeneACHEC0235082Tremor, Muscle1CTD_human
HgeneACHEC0235083Nerve Tremors1CTD_human
HgeneACHEC0235843Tremor, Neonatal1CTD_human
HgeneACHEC0236733Amphetamine-Related Disorders1CTD_human
HgeneACHEC0236804Amphetamine Addiction1CTD_human
HgeneACHEC0236807Amphetamine Abuse1CTD_human
HgeneACHEC0266487Etat Marbre1CTD_human
HgeneACHEC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
HgeneACHEC0376358Malignant neoplasm of prostate1CTD_human
HgeneACHEC0678222Breast Carcinoma1CTD_human
HgeneACHEC0751262Adult Learning Disorders1CTD_human
HgeneACHEC0751263Learning Disturbance1CTD_human
HgeneACHEC0751265Learning Disabilities1CTD_human
HgeneACHEC0751292Age-Related Memory Disorders1CTD_human
HgeneACHEC0751293Memory Disorder, Semantic1CTD_human
HgeneACHEC0751294Memory Disorder, Spatial1CTD_human
HgeneACHEC0751295Memory Loss1CTD_human
HgeneACHEC0751564Pill Rolling Tremor1CTD_human
HgeneACHEC0751565Tremor, Semirhythmic1CTD_human
HgeneACHEC1257931Mammary Neoplasms, Human1CTD_human
HgeneACHEC1266042Chromophobe Renal Cell Carcinoma1CTD_human
HgeneACHEC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
HgeneACHEC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
HgeneACHEC1306837Papillary Renal Cell Carcinoma1CTD_human
HgeneACHEC1330966Developmental Academic Disorder1CTD_human
HgeneACHEC1458155Mammary Neoplasms1CTD_human
HgeneACHEC1527384Involuntary Quiver1CTD_human
HgeneACHEC4704874Mammary Carcinoma, Human1CTD_human