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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CCP110-GOLPH3L (FusionGDB2 ID:14274)

Fusion Gene Summary for CCP110-GOLPH3L

Fusion gene summary

Fusion gene information	Fusion gene name: CCP110-GOLPH3L
	Fusion gene ID: 14274
		Hgene	Tgene
	Gene symbol	CCP110	GOLPH3L
	Gene ID	9738	55204
	Gene name	centriolar coiled-coil protein 110	golgi phosphoprotein 3 like
	Synonyms	CP110\|Cep110	GPP34R
	Cytomap	16p12.3	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	centriolar coiled-coil protein of 110 kDacentriolar coiled-coil protein 110kDacentrosomal protein CP110centrosomal protein of 110 kDa	Golgi phosphoprotein 3-likeGPP34-related protein
	Modification date	20200313	20200313
	UniProtAcc	O43303	Q9H4A5
	Ensembl transtripts involved in fusion gene	ENST00000396212, ENST00000381396, ENST00000573412, ENST00000396208,	ENST00000271732, ENST00000540514, ENST00000479757,
Fusion gene scores	* DoF score	3 X 3 X 2=18	8 X 5 X 7=280
	# samples	3	10
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CCP110 [Title/Abstract] AND GOLPH3L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CCP110(19539344)-GOLPH3L(150621224), # samples:3
Anticipated loss of major functional domain due to fusion event.	CCP110-GOLPH3L seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CCP110	GO:0051298	centrosome duplication	20596027

Fusion gene breakpoints across CCP110 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GOLPH3L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-66-2756-01A	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-
ChimerDB4	LUSC	TCGA-66-2756	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-
ChimerDB4	LUSC	TCGA-66-2756	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-

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Fusion Gene ORF analysis for CCP110-GOLPH3L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000396212	ENST00000271732	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-
In-frame	ENST00000396212	ENST00000540514	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-
5CDS-intron	ENST00000396212	ENST00000479757	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-
Frame-shift	ENST00000381396	ENST00000271732	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-
In-frame	ENST00000381396	ENST00000540514	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-
5CDS-intron	ENST00000381396	ENST00000479757	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-
intron-3CDS	ENST00000573412	ENST00000271732	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-
intron-3CDS	ENST00000573412	ENST00000540514	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-
intron-intron	ENST00000573412	ENST00000479757	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-
Frame-shift	ENST00000396208	ENST00000271732	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-
In-frame	ENST00000396208	ENST00000540514	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-
5CDS-intron	ENST00000396208	ENST00000479757	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000396212	CCP110	chr16	19539344	+	ENST00000540514	GOLPH3L	chr1	150621224	-	1115	577	612	1004	130
ENST00000381396	CCP110	chr16	19539344	+	ENST00000540514	GOLPH3L	chr1	150621224	-	926	388	423	815	130
ENST00000396208	CCP110	chr16	19539344	+	ENST00000540514	GOLPH3L	chr1	150621224	-	826	288	323	715	130

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000396212	ENST00000540514	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-	0.03864879	0.96135116
ENST00000381396	ENST00000540514	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-	0.03563317	0.96436685
ENST00000396208	ENST00000540514	CCP110	chr16	19539344	+	GOLPH3L	chr1	150621224	-	0.046994112	0.95300597

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Fusion Genomic Features for CCP110-GOLPH3L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCP110-GOLPH3L

Go to
FGviewer for the breakpoints of chr16:19539344-chr1:150621224
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CCP110 O43303	GOLPH3L Q9H4A5
FUNCTION: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250\|UniProtKB:Q7TSH4, ECO:0000269\|PubMed:12361598, ECO:0000269\|PubMed:16760425, ECO:0000269\|PubMed:17681131, ECO:0000269\|PubMed:17719545, ECO:0000269\|PubMed:23486064}.	FUNCTION: Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. {ECO:0000269\|PubMed:23345592}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GOLPH3L

chr16:19539344

chr1:150621224

ENST00000271732

176_187

143.33333333333334

286.0

Region

Beta-hairpin required for oligomerization

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000381396

49_90

47.0

1013.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000381396

640_709

47.0

1013.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000396208

49_90

47.0

992.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000396208

640_709

47.0

992.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000396212

49_90

47.0

992.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000396212

640_709

47.0

992.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000381396

1_223

47.0

1013.0

Region

Note=CEP97 binding

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000381396

64_82

47.0

1013.0

Region

Note=Calmodulin-binding

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000381396

781_821

47.0

1013.0

Region

Note=Calmodulin-binding

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000381396

909_924

47.0

1013.0

Region

Note=Calmodulin-binding

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000396208

1_223

47.0

992.0

Region

Note=CEP97 binding

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000396208

64_82

47.0

992.0

Region

Note=Calmodulin-binding

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000396208

781_821

47.0

992.0

Region

Note=Calmodulin-binding

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000396208

909_924

47.0

992.0

Region

Note=Calmodulin-binding

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000396212

1_223

47.0

992.0

Region

Note=CEP97 binding

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000396212

64_82

47.0

992.0

Region

Note=Calmodulin-binding

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000396212

781_821

47.0

992.0

Region

Note=Calmodulin-binding

Hgene

CCP110

chr16:19539344

chr1:150621224

ENST00000396212

909_924

47.0

992.0

Region

Note=Calmodulin-binding

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Fusion Gene Sequence for CCP110-GOLPH3L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000396212_ENST00000540514_TCGA-66-2756-01A_CCP110_chr16_19539344_+_GOLPH3L_chr1_150621224_length(transcript)=1115nt_BP=577nt
AATGCACCTCGGGGATGGTAGTGTTCTGGTGGCCCAACGGTTTTAACAGCCCGGGAATCAACCACCGGAAGTGCCGGCCCTGAGAGGTGG
AGTCGGGGTGGCAGCGGCGGCGGTTGCCAGGAGCCCGCGTTGCAGCCTGAGATCCGTAATATGGCGGGGAGGAGGAGGAGAAGGCGGCGG
CGGACCGAGCTGCGCTCTGTCAGTACCATTTGAGCCATTCGCTTCCTGACAAGGCCCGTGGCGAGGGGAGAGGAGCTGAAGGGGCCGTGG
GGGATCAGTGCCTGCTGTGTGCTGATACTGTTCTGTGTAATGGGGATTCAGTGAACAAGACTGAAAAGGTACCTGTACTTATGGCGCTTA
CATTTTGGTGGAGGAAGACAGACAAAAATCAAGGAAATAAACACGATAATTTCAGATAGTGTGTGACTGTGGGAAGATGGAGGAGTATGA
GAAGTTCTGTGAAAAAAGTCTTGCCAGAATACAAGAAGCATCACTATCCACAGAGAGCTTTCTCCCTGCTCAGTCTGAAAGTATCTCACT
TATTCGCTTTCATGGAGTGGCTATCCTTTCTCCACTGGTGAGACCTGGAACCCCTTCAAATTACAGTACCAGCTGAGAAATGTACGAGAG
CGCATCGCAAAGAACCTAGTAGAGAAAGGTATTCTAACCACTGAGAAGCAGAATTTCCTGCTATTTGACATGACTACTCATCCAGTGACC
AATACAACAGAGAAACAGCGACTAGTGAAAAAACTTCAAGATAGTGTACTAGAGCGGTGGGTAAATGACCCTCAGCGTATGGACAAGCGA
ACACTAGCACTCCTGGTGCTAGCCCACTCCTCTGATGTGCTAGAGAATGTCTTCTCCTCTCTGACAGATGACAAGTATGATGTGGCAATG
AATCGAGCCAAGGACTTAGTAGAACTGGACCCTGAAGTGGAAGGGACAAAGCCTAGTGCCACAGAAATGATCTGGGCTGTGCTGGCAGCC
TTCAATAAATCTTAAAGCCGGCAGGTGGATTTCTCCTTTTCCCCTGCTGGCTGGTGACTGTCAGAGACCCCATCACTGAGTTTTGTGTGA

>In-frame_ENST00000396212_ENST00000540514_TCGA-66-2756-01A_CCP110_chr16_19539344_+_GOLPH3L_chr1_150621224_length(amino acids)=130AA_start in transcript=612_stop in transcript=1004
MRNVRERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQDSVLERWVNDPQRMDKRTLALLVLAHSSDVLENVFSSLTDD

--------------------------------------------------------------
>In-frame_ENST00000381396_ENST00000540514_TCGA-66-2756-01A_CCP110_chr16_19539344_+_GOLPH3L_chr1_150621224_length(transcript)=926nt_BP=388nt
CAGCCCGGGAATCAACCACCGGAAGTGCCGGCCCTGAGAGGTGGAGTCGGGGTGGCAGCGGCGGCGGTTGCCAGGAGCCCGCGTTGCAGC
CTGAGATCCGTAATATGGCGGGGAGGAGGAGGAGAAGGCGGCGGCGGACCGAGCTGCGCTCTGTCAGTACCATTTGAGCCATTCGCTTCC
TGACAAGGCCCGTGGCGAGGGGAGAGGAGCTGAAGGGGCCGTGGGGGATCAGTGTGACTGTGGGAAGATGGAGGAGTATGAGAAGTTCTG
TGAAAAAAGTCTTGCCAGAATACAAGAAGCATCACTATCCACAGAGAGCTTTCTCCCTGCTCAGTCTGAAAGTATCTCACTTATTCGCTT
TCATGGAGTGGCTATCCTTTCTCCACTGGTGAGACCTGGAACCCCTTCAAATTACAGTACCAGCTGAGAAATGTACGAGAGCGCATCGCA
AAGAACCTAGTAGAGAAAGGTATTCTAACCACTGAGAAGCAGAATTTCCTGCTATTTGACATGACTACTCATCCAGTGACCAATACAACA
GAGAAACAGCGACTAGTGAAAAAACTTCAAGATAGTGTACTAGAGCGGTGGGTAAATGACCCTCAGCGTATGGACAAGCGAACACTAGCA
CTCCTGGTGCTAGCCCACTCCTCTGATGTGCTAGAGAATGTCTTCTCCTCTCTGACAGATGACAAGTATGATGTGGCAATGAATCGAGCC
AAGGACTTAGTAGAACTGGACCCTGAAGTGGAAGGGACAAAGCCTAGTGCCACAGAAATGATCTGGGCTGTGCTGGCAGCCTTCAATAAA
TCTTAAAGCCGGCAGGTGGATTTCTCCTTTTCCCCTGCTGGCTGGTGACTGTCAGAGACCCCATCACTGAGTTTTGTGTGATGAGATGTT

>In-frame_ENST00000381396_ENST00000540514_TCGA-66-2756-01A_CCP110_chr16_19539344_+_GOLPH3L_chr1_150621224_length(amino acids)=130AA_start in transcript=423_stop in transcript=815
MRNVRERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQDSVLERWVNDPQRMDKRTLALLVLAHSSDVLENVFSSLTDD

--------------------------------------------------------------
>In-frame_ENST00000396208_ENST00000540514_TCGA-66-2756-01A_CCP110_chr16_19539344_+_GOLPH3L_chr1_150621224_length(transcript)=826nt_BP=288nt
TAATATGGCGGGGAGGAGGAGGAGAAGGCGGCGGCGGACCGAGCTGCGCTCTGTCAGTACCATTTGAGCCATTCGCTTCCTGACAAGGCC
CGTGGCGAGGGGAGAGGAGCTGAAGGGGCCGTGGGGGATCAGTGTGACTGTGGGAAGATGGAGGAGTATGAGAAGTTCTGTGAAAAAAGT
CTTGCCAGAATACAAGAAGCATCACTATCCACAGAGAGCTTTCTCCCTGCTCAGTCTGAAAGTATCTCACTTATTCGCTTTCATGGAGTG
GCTATCCTTTCTCCACTGGTGAGACCTGGAACCCCTTCAAATTACAGTACCAGCTGAGAAATGTACGAGAGCGCATCGCAAAGAACCTAG
TAGAGAAAGGTATTCTAACCACTGAGAAGCAGAATTTCCTGCTATTTGACATGACTACTCATCCAGTGACCAATACAACAGAGAAACAGC
GACTAGTGAAAAAACTTCAAGATAGTGTACTAGAGCGGTGGGTAAATGACCCTCAGCGTATGGACAAGCGAACACTAGCACTCCTGGTGC
TAGCCCACTCCTCTGATGTGCTAGAGAATGTCTTCTCCTCTCTGACAGATGACAAGTATGATGTGGCAATGAATCGAGCCAAGGACTTAG
TAGAACTGGACCCTGAAGTGGAAGGGACAAAGCCTAGTGCCACAGAAATGATCTGGGCTGTGCTGGCAGCCTTCAATAAATCTTAAAGCC
GGCAGGTGGATTTCTCCTTTTCCCCTGCTGGCTGGTGACTGTCAGAGACCCCATCACTGAGTTTTGTGTGATGAGATGTTTTCATCATTT

>In-frame_ENST00000396208_ENST00000540514_TCGA-66-2756-01A_CCP110_chr16_19539344_+_GOLPH3L_chr1_150621224_length(amino acids)=130AA_start in transcript=323_stop in transcript=715
MRNVRERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQDSVLERWVNDPQRMDKRTLALLVLAHSSDVLENVFSSLTDD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CCP110-GOLPH3L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CCP110	chr16:19539344	chr1:150621224	ENST00000381396	+	2	15	350_565	47.0	1013.0	CEP76
Hgene	CCP110	chr16:19539344	chr1:150621224	ENST00000396208	+	2	14	350_565	47.0	992.0	CEP76
Hgene	CCP110	chr16:19539344	chr1:150621224	ENST00000396212	+	3	15	350_565	47.0	992.0	CEP76

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CCP110-GOLPH3L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CCP110-GOLPH3L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source