FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CCSER1-SPARCL1 (FusionGDB2 ID:14302)

Fusion Gene Summary for CCSER1-SPARCL1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCSER1-SPARCL1
Fusion gene ID: 14302
HgeneTgene
Gene symbol

CCSER1

SPARCL1

Gene ID

401145

8404

Gene namecoiled-coil serine rich protein 1SPARC like 1
SynonymsFAM190AMAST 9|MAST9|PIG33|SC1
Cytomap

4q22.1

4q22.1

Type of geneprotein-codingprotein-coding
Descriptionserine-rich coiled-coil domain-containing protein 1family with sequence similarity 190, member Aprotein FAM190ASPARC-like protein 1SPARC-like 1 (hevin)high endothelial venule proteinproliferation-inducing protein 33
Modification date2020031320200313
UniProtAcc

Q9C0I3

.
Ensembl transtripts involved in fusion geneENST00000509176, ENST00000333691, 
ENST00000432775, ENST00000504150, 
ENST00000282470, ENST00000418378, 
ENST00000503414, 
Fusion gene scores* DoF score16 X 13 X 7=145614 X 14 X 5=980
# samples 1817
** MAII scorelog2(18/1456*10)=-3.01594154386902
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/980*10)=-2.52724700286487
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCSER1 [Title/Abstract] AND SPARCL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCSER1(91389505)-SPARCL1(88394955), # samples:2
Anticipated loss of major functional domain due to fusion event.CCSER1-SPARCL1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CCSER1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SPARCL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-AA68-01ACCSER1chr4

91389505

+SPARCL1chr4

88394955

-
ChimerDB4STADTCGA-VQ-AA68-01ACCSER1chr4

91389505

+SPARCL1chr4

88394955

-


Top

Fusion Gene ORF analysis for CCSER1-SPARCL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000509176ENST00000282470CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
In-frameENST00000509176ENST00000418378CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
In-frameENST00000509176ENST00000503414CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
Frame-shiftENST00000333691ENST00000282470CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
In-frameENST00000333691ENST00000418378CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
In-frameENST00000333691ENST00000503414CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
Frame-shiftENST00000432775ENST00000282470CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
In-frameENST00000432775ENST00000418378CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
In-frameENST00000432775ENST00000503414CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
intron-3CDSENST00000504150ENST00000282470CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
intron-3CDSENST00000504150ENST00000418378CCSER1chr4

91389505

+SPARCL1chr4

88394955

-
intron-3CDSENST00000504150ENST00000503414CCSER1chr4

91389505

+SPARCL1chr4

88394955

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000509176CCSER1chr491389505+ENST00000418378SPARCL1chr488394955-246820122882024578
ENST00000509176CCSER1chr491389505+ENST00000503414SPARCL1chr488394955-239820122882024578
ENST00000333691CCSER1chr491389505+ENST00000418378SPARCL1chr488394955-253420783542090578
ENST00000333691CCSER1chr491389505+ENST00000503414SPARCL1chr488394955-246420783542090578
ENST00000432775CCSER1chr491389505+ENST00000418378SPARCL1chr488394955-253420783542090578
ENST00000432775CCSER1chr491389505+ENST00000503414SPARCL1chr488394955-246420783542090578

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000509176ENST00000418378CCSER1chr491389505+SPARCL1chr488394955-0.001009320.9989907
ENST00000509176ENST00000503414CCSER1chr491389505+SPARCL1chr488394955-0.0013481580.9986519
ENST00000333691ENST00000418378CCSER1chr491389505+SPARCL1chr488394955-0.0010817960.9989182
ENST00000333691ENST00000503414CCSER1chr491389505+SPARCL1chr488394955-0.0013852480.9986148
ENST00000432775ENST00000418378CCSER1chr491389505+SPARCL1chr488394955-0.0010817960.9989182
ENST00000432775ENST00000503414CCSER1chr491389505+SPARCL1chr488394955-0.0013852480.9986148

Top

Fusion Genomic Features for CCSER1-SPARCL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CCSER1-SPARCL1


check button Go to

FGviewer for the breakpoints of chr4:91389505-chr4:88394955

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCSER1

Q9C0I3

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCSER1chr4:91389505chr4:88394955ENST00000333691+511495_498574.6666666666666901.0Compositional biasNote=Poly-Ser
HgeneCCSER1chr4:91389505chr4:88394955ENST00000333691+5114_69574.6666666666666901.0Compositional biasNote=Ser-rich
HgeneCCSER1chr4:91389505chr4:88394955ENST00000432775+58495_498574.6666666666666678.0Compositional biasNote=Poly-Ser
HgeneCCSER1chr4:91389505chr4:88394955ENST00000432775+584_69574.6666666666666678.0Compositional biasNote=Ser-rich
HgeneCCSER1chr4:91389505chr4:88394955ENST00000509176+511495_498574.6666666666666901.0Compositional biasNote=Poly-Ser
HgeneCCSER1chr4:91389505chr4:88394955ENST00000509176+5114_69574.6666666666666901.0Compositional biasNote=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCCSER1chr4:91389505chr4:88394955ENST00000333691+511673_707574.6666666666666901.0Coiled coilOntology_term=ECO:0000255
HgeneCCSER1chr4:91389505chr4:88394955ENST00000432775+58673_707574.6666666666666678.0Coiled coilOntology_term=ECO:0000255
HgeneCCSER1chr4:91389505chr4:88394955ENST00000509176+511673_707574.6666666666666901.0Coiled coilOntology_term=ECO:0000255
TgeneSPARCL1chr4:91389505chr4:88394955ENST00000282470911635_646655.3333333333334665.0Calcium bindingOntology_term=ECO:0000255
TgeneSPARCL1chr4:91389505chr4:88394955ENST000004183781012635_646655.3333333333334665.0Calcium bindingOntology_term=ECO:0000255
TgeneSPARCL1chr4:91389505chr4:88394955ENST00000282470911432_454655.3333333333334665.0DomainNote=Follistatin-like
TgeneSPARCL1chr4:91389505chr4:88394955ENST00000282470911450_511655.3333333333334665.0DomainKazal-like
TgeneSPARCL1chr4:91389505chr4:88394955ENST00000282470911622_657655.3333333333334665.0DomainEF-hand
TgeneSPARCL1chr4:91389505chr4:88394955ENST000004183781012432_454655.3333333333334665.0DomainNote=Follistatin-like
TgeneSPARCL1chr4:91389505chr4:88394955ENST000004183781012450_511655.3333333333334665.0DomainKazal-like
TgeneSPARCL1chr4:91389505chr4:88394955ENST000004183781012622_657655.3333333333334665.0DomainEF-hand
TgeneSPARCL1chr4:91389505chr4:88394955ENST0000028247091125_34655.3333333333334665.0RegionNote=O-glycosylated at one additional site
TgeneSPARCL1chr4:91389505chr4:88394955ENST00000418378101225_34655.3333333333334665.0RegionNote=O-glycosylated at one additional site


Top

Fusion Gene Sequence for CCSER1-SPARCL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000509176_ENST00000418378_TCGA-VQ-AA68-01A_CCSER1_chr4_91389505_+_SPARCL1_chr4_88394955_length(transcript)=2468nt_BP=2012nt
GTCTCAACATGACTGACTGGGAAGCGGTGGCTCGGGCAGAGCAGCTCCGCTGGCGCAGGCAGGAGGAGCAGGAGGATTATTAAATAACGC
AGCTGGACTCTGTGCAACTGGGAGTGGAGAGGAGCCCAACAGCCGAGAAGGGGAGGGAGGGCAGAGGAGGGGGACCAGGAAGGACACCCC
CGTGCCCCGAAGACATAAATCCCTGAGTGCCCGGGAGGAGCCTTAACAAGCGCACGGAGCCCTCAAGGCTGCAAAGTTGGCTTTCACAGT
GCAAGCCTTTGATTCCCAATGGGGGACTCAGGATCAAGACGATCTACCCTGGTCTCCCGGTTGCCAATATTCAGAAGAAGTATTAACAGA
AGACATGATTCTCTTCCTTCTTCACCTTCTTCCAGTAATACAGTTGGTGTCCACAGTTCCTCTCCTTCCAGCACTAACTCAAGCTCAGGT
AGCACAGGTAAACGGAGGAGCATATTCCGTACTCCTTCCATTAGCTTCCACCATAAGAAGGGGAGTGAGCCTAAGCAAGAGCCTACCAAC
CAGAACCTTAGTATTTCAAATGGTGCTCAACCTGGTCACAGCAATATGCAGAAACTGAGTTTGGAAGAACATATTAAGACCAGGGGAAGA
CATTCTGTTGGTTTTAGTAGTTCACGAAATAAGAAGATAACAAGATCTTTGACAGAGGATTTTGAAAGGGAAAAAGAGCACTCAACTAAC
AAGAATGTCTTTATAAATTGTCTAAGTTCTGGCAAAAGTGAAGGGGATGATTCTGGTTTCACAGAAGACCAAACTCGTCGTTCTGTTAAG
CAGTCAACAAGGAAGCTACTCCCTAAATCTTTTTCATCTCACTATAAATTTTCTAAGCCAGTTCTACAGAGCCAATCCATTTCATTGGTA
CAACAGTCTGAATTCTCATTGGAAGTTACACAGTACCAAGAGAGAGAACCTGTATTAGTAAGAGCTTCGCCATCCTGTTCTGTGGATGTA
ACAGAACGGGCAGGAAGCTCTTTACAATCTCCTTTGCTTTCTGCTGATCTTACCACAGCTCAGACACCTTCAGAATTTTTAGCCTTGACT
GAAGATTCTGTGTCTGAAATGGATGCATTTTCTAAAAGTGGAAGCATGGCATCCCACTGTGACAACTTTGGCCACAATGATTCTACCTCT
CAGATGTCCCTCAATTCTGCTGCTGTTACAAAGACAACAACAGAACTTACGGGAACTGTTCCCTGTGCAATTATGTCTCCTGGGAAATAT
AGGTTAGAGGGTCAATGTAGCACTGAATCTAATTCATTACCGGAAACCTCTGCTGCTAATCAGAAGGAAGTGTTATTACAAATTGCTGAA
CTACCTGCTACAAGTGTGAGCCACTCAGAGAGTAACCTACCAGCAGATAGTGAAAGAGAAGAAAATATAGGGTTACAAAATGGTGAAACA
ATGCTGGGGACAAACTCCCCAAGGAAACTTGGATTTTATGAGCAACATAAAGCAATAGCGGAACATGTAAAAGGGATCCATCCTATTTCA
GATTCAAAGATAATACCTACTTCTGGTGATCATCATATTTTTAACAAAACATCACATGGATATGAAGCAAATCCTGCCAAAGTTCTTGCC
AGTAGTCTCAGTCCATTTCGTGAAGGAAGATTTATAGAGAGGAGACTGCGATCCTCGTCAGAAGGCACTGCAGGGAGTAGCAGAATGATT
TTGAAACCGAAAGATGGAAATATAGAAGAAGTTAATAGTTTAAGAAAGCAAAGAGCAGGTTCTTCATCTTCAAAAATGAACAGTTTGGAT
GTTTTGAATAATTTGGGATCTTGTGAACTGGATGAAGATGATCTAATGCTTGATCTTGAATTTTTAGAGGAACAGAGTCTTCACCCTTCT
GTTTGCCGGGAGGACTCATATCACTCTGTCGTCTCATGTGCCGCAGTAGTTCTTACTCCTATGGAACCAATGATAGAAATGAAGAAAAGA
GAAGAACCAGAATTTCCTGAGCCTTCCAAACAAGGACATAGATGAAAATCTCTTGTTTTGAACGAAGATTTTAAAGAACTCAACTTTCCA
GCATCCTCCTCTGTTCTAACCACTTCAGAAATATATGCAGCTGTGATACTTGTAGATTTATATTTAGCAAAATGTTAGCATGTATGACAA
GACAATGAGAGTAATTGCTTGACAACAACCTATGCACCAGGTATTTAACATTAACTTTGGAAACAAAAATGTACAATTAAGTAAAGTCAA
CATATGCAAAATACTGTACATTGTGAACAGAAGTTTAATTCATAGTAATTTCACTCTCTGCATTGACTTATGAGATAATTAATGATTAAA
CTATTAATGATAAAAATAATGCATTTGTATTGTTCATAATATCATGTGCACTTCAAGAAAATGGAATGCTACTCTTTTGTGGTTTACGTG

>In-frame_ENST00000509176_ENST00000418378_TCGA-VQ-AA68-01A_CCSER1_chr4_91389505_+_SPARCL1_chr4_88394955_length(amino acids)=578AA_start in transcript=288_stop in transcript=2024
MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSIS
NGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSE
MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPF
REGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS

--------------------------------------------------------------
>In-frame_ENST00000509176_ENST00000503414_TCGA-VQ-AA68-01A_CCSER1_chr4_91389505_+_SPARCL1_chr4_88394955_length(transcript)=2398nt_BP=2012nt
GTCTCAACATGACTGACTGGGAAGCGGTGGCTCGGGCAGAGCAGCTCCGCTGGCGCAGGCAGGAGGAGCAGGAGGATTATTAAATAACGC
AGCTGGACTCTGTGCAACTGGGAGTGGAGAGGAGCCCAACAGCCGAGAAGGGGAGGGAGGGCAGAGGAGGGGGACCAGGAAGGACACCCC
CGTGCCCCGAAGACATAAATCCCTGAGTGCCCGGGAGGAGCCTTAACAAGCGCACGGAGCCCTCAAGGCTGCAAAGTTGGCTTTCACAGT
GCAAGCCTTTGATTCCCAATGGGGGACTCAGGATCAAGACGATCTACCCTGGTCTCCCGGTTGCCAATATTCAGAAGAAGTATTAACAGA
AGACATGATTCTCTTCCTTCTTCACCTTCTTCCAGTAATACAGTTGGTGTCCACAGTTCCTCTCCTTCCAGCACTAACTCAAGCTCAGGT
AGCACAGGTAAACGGAGGAGCATATTCCGTACTCCTTCCATTAGCTTCCACCATAAGAAGGGGAGTGAGCCTAAGCAAGAGCCTACCAAC
CAGAACCTTAGTATTTCAAATGGTGCTCAACCTGGTCACAGCAATATGCAGAAACTGAGTTTGGAAGAACATATTAAGACCAGGGGAAGA
CATTCTGTTGGTTTTAGTAGTTCACGAAATAAGAAGATAACAAGATCTTTGACAGAGGATTTTGAAAGGGAAAAAGAGCACTCAACTAAC
AAGAATGTCTTTATAAATTGTCTAAGTTCTGGCAAAAGTGAAGGGGATGATTCTGGTTTCACAGAAGACCAAACTCGTCGTTCTGTTAAG
CAGTCAACAAGGAAGCTACTCCCTAAATCTTTTTCATCTCACTATAAATTTTCTAAGCCAGTTCTACAGAGCCAATCCATTTCATTGGTA
CAACAGTCTGAATTCTCATTGGAAGTTACACAGTACCAAGAGAGAGAACCTGTATTAGTAAGAGCTTCGCCATCCTGTTCTGTGGATGTA
ACAGAACGGGCAGGAAGCTCTTTACAATCTCCTTTGCTTTCTGCTGATCTTACCACAGCTCAGACACCTTCAGAATTTTTAGCCTTGACT
GAAGATTCTGTGTCTGAAATGGATGCATTTTCTAAAAGTGGAAGCATGGCATCCCACTGTGACAACTTTGGCCACAATGATTCTACCTCT
CAGATGTCCCTCAATTCTGCTGCTGTTACAAAGACAACAACAGAACTTACGGGAACTGTTCCCTGTGCAATTATGTCTCCTGGGAAATAT
AGGTTAGAGGGTCAATGTAGCACTGAATCTAATTCATTACCGGAAACCTCTGCTGCTAATCAGAAGGAAGTGTTATTACAAATTGCTGAA
CTACCTGCTACAAGTGTGAGCCACTCAGAGAGTAACCTACCAGCAGATAGTGAAAGAGAAGAAAATATAGGGTTACAAAATGGTGAAACA
ATGCTGGGGACAAACTCCCCAAGGAAACTTGGATTTTATGAGCAACATAAAGCAATAGCGGAACATGTAAAAGGGATCCATCCTATTTCA
GATTCAAAGATAATACCTACTTCTGGTGATCATCATATTTTTAACAAAACATCACATGGATATGAAGCAAATCCTGCCAAAGTTCTTGCC
AGTAGTCTCAGTCCATTTCGTGAAGGAAGATTTATAGAGAGGAGACTGCGATCCTCGTCAGAAGGCACTGCAGGGAGTAGCAGAATGATT
TTGAAACCGAAAGATGGAAATATAGAAGAAGTTAATAGTTTAAGAAAGCAAAGAGCAGGTTCTTCATCTTCAAAAATGAACAGTTTGGAT
GTTTTGAATAATTTGGGATCTTGTGAACTGGATGAAGATGATCTAATGCTTGATCTTGAATTTTTAGAGGAACAGAGTCTTCACCCTTCT
GTTTGCCGGGAGGACTCATATCACTCTGTCGTCTCATGTGCCGCAGTAGTTCTTACTCCTATGGAACCAATGATAGAAATGAAGAAAAGA
GAAGAACCAGAATTTCCTGAGCCTTCCAAACAAGGACATAGATGAAAATCTCTTGTTTTGAACGAAGATTTTAAAGAACTCAACTTTCCA
GCATCCTCCTCTGTTCTAACCACTTCAGAAATATATGCAGCTGTGATACTTGTAGATTTATATTTAGCAAAATGTTAGCATGTATGACAA
GACAATGAGAGTAATTGCTTGACAACAACCTATGCACCAGGTATTTAACATTAACTTTGGAAACAAAAATGTACAATTAAGTAAAGTCAA
CATATGCAAAATACTGTACATTGTGAACAGAAGTTTAATTCATAGTAATTTCACTCTCTGCATTGACTTATGAGATAATTAATGATTAAA

>In-frame_ENST00000509176_ENST00000503414_TCGA-VQ-AA68-01A_CCSER1_chr4_91389505_+_SPARCL1_chr4_88394955_length(amino acids)=578AA_start in transcript=288_stop in transcript=2024
MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSIS
NGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSE
MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPF
REGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS

--------------------------------------------------------------
>In-frame_ENST00000333691_ENST00000418378_TCGA-VQ-AA68-01A_CCSER1_chr4_91389505_+_SPARCL1_chr4_88394955_length(transcript)=2534nt_BP=2078nt
GTTACCATCGAGACCGGGGCTGTGTATGCTCGAGGTGCAGGGAGCTAATGTATAAGGAGTTAAATGAACTCTTGCTGCTGCCAAATATGT
TGTTATCACTAACTGCACCGCTGCTGTCATTAGTGCTGCTGCCAACACTGCAAGCCCTGCTGCTGCCAGTGCCAATTCTGCTGATGCCTT
GGGCTCTCCATGTCCCAGGGTGATTCCATAGACAAGCAGCTGCTTTTAGATTTCACTTGCTCATTACCTGTAGATCCTTTGCCTTAGGAC
TCAAGCTTAAGCCCATGAAGCCTGGGATAGAAGACAATTGGAGGCTGCAAAGTTGGCTTTCACAGTGCAAGCCTTTGATTCCCAATGGGG
GACTCAGGATCAAGACGATCTACCCTGGTCTCCCGGTTGCCAATATTCAGAAGAAGTATTAACAGAAGACATGATTCTCTTCCTTCTTCA
CCTTCTTCCAGTAATACAGTTGGTGTCCACAGTTCCTCTCCTTCCAGCACTAACTCAAGCTCAGGTAGCACAGGTAAACGGAGGAGCATA
TTCCGTACTCCTTCCATTAGCTTCCACCATAAGAAGGGGAGTGAGCCTAAGCAAGAGCCTACCAACCAGAACCTTAGTATTTCAAATGGT
GCTCAACCTGGTCACAGCAATATGCAGAAACTGAGTTTGGAAGAACATATTAAGACCAGGGGAAGACATTCTGTTGGTTTTAGTAGTTCA
CGAAATAAGAAGATAACAAGATCTTTGACAGAGGATTTTGAAAGGGAAAAAGAGCACTCAACTAACAAGAATGTCTTTATAAATTGTCTA
AGTTCTGGCAAAAGTGAAGGGGATGATTCTGGTTTCACAGAAGACCAAACTCGTCGTTCTGTTAAGCAGTCAACAAGGAAGCTACTCCCT
AAATCTTTTTCATCTCACTATAAATTTTCTAAGCCAGTTCTACAGAGCCAATCCATTTCATTGGTACAACAGTCTGAATTCTCATTGGAA
GTTACACAGTACCAAGAGAGAGAACCTGTATTAGTAAGAGCTTCGCCATCCTGTTCTGTGGATGTAACAGAACGGGCAGGAAGCTCTTTA
CAATCTCCTTTGCTTTCTGCTGATCTTACCACAGCTCAGACACCTTCAGAATTTTTAGCCTTGACTGAAGATTCTGTGTCTGAAATGGAT
GCATTTTCTAAAAGTGGAAGCATGGCATCCCACTGTGACAACTTTGGCCACAATGATTCTACCTCTCAGATGTCCCTCAATTCTGCTGCT
GTTACAAAGACAACAACAGAACTTACGGGAACTGTTCCCTGTGCAATTATGTCTCCTGGGAAATATAGGTTAGAGGGTCAATGTAGCACT
GAATCTAATTCATTACCGGAAACCTCTGCTGCTAATCAGAAGGAAGTGTTATTACAAATTGCTGAACTACCTGCTACAAGTGTGAGCCAC
TCAGAGAGTAACCTACCAGCAGATAGTGAAAGAGAAGAAAATATAGGGTTACAAAATGGTGAAACAATGCTGGGGACAAACTCCCCAAGG
AAACTTGGATTTTATGAGCAACATAAAGCAATAGCGGAACATGTAAAAGGGATCCATCCTATTTCAGATTCAAAGATAATACCTACTTCT
GGTGATCATCATATTTTTAACAAAACATCACATGGATATGAAGCAAATCCTGCCAAAGTTCTTGCCAGTAGTCTCAGTCCATTTCGTGAA
GGAAGATTTATAGAGAGGAGACTGCGATCCTCGTCAGAAGGCACTGCAGGGAGTAGCAGAATGATTTTGAAACCGAAAGATGGAAATATA
GAAGAAGTTAATAGTTTAAGAAAGCAAAGAGCAGGTTCTTCATCTTCAAAAATGAACAGTTTGGATGTTTTGAATAATTTGGGATCTTGT
GAACTGGATGAAGATGATCTAATGCTTGATCTTGAATTTTTAGAGGAACAGAGTCTTCACCCTTCTGTTTGCCGGGAGGACTCATATCAC
TCTGTCGTCTCATGTGCCGCAGTAGTTCTTACTCCTATGGAACCAATGATAGAAATGAAGAAAAGAGAAGAACCAGAATTTCCTGAGCCT
TCCAAACAAGGACATAGATGAAAATCTCTTGTTTTGAACGAAGATTTTAAAGAACTCAACTTTCCAGCATCCTCCTCTGTTCTAACCACT
TCAGAAATATATGCAGCTGTGATACTTGTAGATTTATATTTAGCAAAATGTTAGCATGTATGACAAGACAATGAGAGTAATTGCTTGACA
ACAACCTATGCACCAGGTATTTAACATTAACTTTGGAAACAAAAATGTACAATTAAGTAAAGTCAACATATGCAAAATACTGTACATTGT
GAACAGAAGTTTAATTCATAGTAATTTCACTCTCTGCATTGACTTATGAGATAATTAATGATTAAACTATTAATGATAAAAATAATGCAT
TTGTATTGTTCATAATATCATGTGCACTTCAAGAAAATGGAATGCTACTCTTTTGTGGTTTACGTGTATTATTTTCAATATCTTAATACC

>In-frame_ENST00000333691_ENST00000418378_TCGA-VQ-AA68-01A_CCSER1_chr4_91389505_+_SPARCL1_chr4_88394955_length(amino acids)=578AA_start in transcript=354_stop in transcript=2090
MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSIS
NGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSE
MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPF
REGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS

--------------------------------------------------------------
>In-frame_ENST00000333691_ENST00000503414_TCGA-VQ-AA68-01A_CCSER1_chr4_91389505_+_SPARCL1_chr4_88394955_length(transcript)=2464nt_BP=2078nt
GTTACCATCGAGACCGGGGCTGTGTATGCTCGAGGTGCAGGGAGCTAATGTATAAGGAGTTAAATGAACTCTTGCTGCTGCCAAATATGT
TGTTATCACTAACTGCACCGCTGCTGTCATTAGTGCTGCTGCCAACACTGCAAGCCCTGCTGCTGCCAGTGCCAATTCTGCTGATGCCTT
GGGCTCTCCATGTCCCAGGGTGATTCCATAGACAAGCAGCTGCTTTTAGATTTCACTTGCTCATTACCTGTAGATCCTTTGCCTTAGGAC
TCAAGCTTAAGCCCATGAAGCCTGGGATAGAAGACAATTGGAGGCTGCAAAGTTGGCTTTCACAGTGCAAGCCTTTGATTCCCAATGGGG
GACTCAGGATCAAGACGATCTACCCTGGTCTCCCGGTTGCCAATATTCAGAAGAAGTATTAACAGAAGACATGATTCTCTTCCTTCTTCA
CCTTCTTCCAGTAATACAGTTGGTGTCCACAGTTCCTCTCCTTCCAGCACTAACTCAAGCTCAGGTAGCACAGGTAAACGGAGGAGCATA
TTCCGTACTCCTTCCATTAGCTTCCACCATAAGAAGGGGAGTGAGCCTAAGCAAGAGCCTACCAACCAGAACCTTAGTATTTCAAATGGT
GCTCAACCTGGTCACAGCAATATGCAGAAACTGAGTTTGGAAGAACATATTAAGACCAGGGGAAGACATTCTGTTGGTTTTAGTAGTTCA
CGAAATAAGAAGATAACAAGATCTTTGACAGAGGATTTTGAAAGGGAAAAAGAGCACTCAACTAACAAGAATGTCTTTATAAATTGTCTA
AGTTCTGGCAAAAGTGAAGGGGATGATTCTGGTTTCACAGAAGACCAAACTCGTCGTTCTGTTAAGCAGTCAACAAGGAAGCTACTCCCT
AAATCTTTTTCATCTCACTATAAATTTTCTAAGCCAGTTCTACAGAGCCAATCCATTTCATTGGTACAACAGTCTGAATTCTCATTGGAA
GTTACACAGTACCAAGAGAGAGAACCTGTATTAGTAAGAGCTTCGCCATCCTGTTCTGTGGATGTAACAGAACGGGCAGGAAGCTCTTTA
CAATCTCCTTTGCTTTCTGCTGATCTTACCACAGCTCAGACACCTTCAGAATTTTTAGCCTTGACTGAAGATTCTGTGTCTGAAATGGAT
GCATTTTCTAAAAGTGGAAGCATGGCATCCCACTGTGACAACTTTGGCCACAATGATTCTACCTCTCAGATGTCCCTCAATTCTGCTGCT
GTTACAAAGACAACAACAGAACTTACGGGAACTGTTCCCTGTGCAATTATGTCTCCTGGGAAATATAGGTTAGAGGGTCAATGTAGCACT
GAATCTAATTCATTACCGGAAACCTCTGCTGCTAATCAGAAGGAAGTGTTATTACAAATTGCTGAACTACCTGCTACAAGTGTGAGCCAC
TCAGAGAGTAACCTACCAGCAGATAGTGAAAGAGAAGAAAATATAGGGTTACAAAATGGTGAAACAATGCTGGGGACAAACTCCCCAAGG
AAACTTGGATTTTATGAGCAACATAAAGCAATAGCGGAACATGTAAAAGGGATCCATCCTATTTCAGATTCAAAGATAATACCTACTTCT
GGTGATCATCATATTTTTAACAAAACATCACATGGATATGAAGCAAATCCTGCCAAAGTTCTTGCCAGTAGTCTCAGTCCATTTCGTGAA
GGAAGATTTATAGAGAGGAGACTGCGATCCTCGTCAGAAGGCACTGCAGGGAGTAGCAGAATGATTTTGAAACCGAAAGATGGAAATATA
GAAGAAGTTAATAGTTTAAGAAAGCAAAGAGCAGGTTCTTCATCTTCAAAAATGAACAGTTTGGATGTTTTGAATAATTTGGGATCTTGT
GAACTGGATGAAGATGATCTAATGCTTGATCTTGAATTTTTAGAGGAACAGAGTCTTCACCCTTCTGTTTGCCGGGAGGACTCATATCAC
TCTGTCGTCTCATGTGCCGCAGTAGTTCTTACTCCTATGGAACCAATGATAGAAATGAAGAAAAGAGAAGAACCAGAATTTCCTGAGCCT
TCCAAACAAGGACATAGATGAAAATCTCTTGTTTTGAACGAAGATTTTAAAGAACTCAACTTTCCAGCATCCTCCTCTGTTCTAACCACT
TCAGAAATATATGCAGCTGTGATACTTGTAGATTTATATTTAGCAAAATGTTAGCATGTATGACAAGACAATGAGAGTAATTGCTTGACA
ACAACCTATGCACCAGGTATTTAACATTAACTTTGGAAACAAAAATGTACAATTAAGTAAAGTCAACATATGCAAAATACTGTACATTGT
GAACAGAAGTTTAATTCATAGTAATTTCACTCTCTGCATTGACTTATGAGATAATTAATGATTAAACTATTAATGATAAAAATAATGCAT

>In-frame_ENST00000333691_ENST00000503414_TCGA-VQ-AA68-01A_CCSER1_chr4_91389505_+_SPARCL1_chr4_88394955_length(amino acids)=578AA_start in transcript=354_stop in transcript=2090
MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSIS
NGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSE
MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPF
REGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS

--------------------------------------------------------------
>In-frame_ENST00000432775_ENST00000418378_TCGA-VQ-AA68-01A_CCSER1_chr4_91389505_+_SPARCL1_chr4_88394955_length(transcript)=2534nt_BP=2078nt
GTTACCATCGAGACCGGGGCTGTGTATGCTCGAGGTGCAGGGAGCTAATGTATAAGGAGTTAAATGAACTCTTGCTGCTGCCAAATATGT
TGTTATCACTAACTGCACCGCTGCTGTCATTAGTGCTGCTGCCAACACTGCAAGCCCTGCTGCTGCCAGTGCCAATTCTGCTGATGCCTT
GGGCTCTCCATGTCCCAGGGTGATTCCATAGACAAGCAGCTGCTTTTAGATTTCACTTGCTCATTACCTGTAGATCCTTTGCCTTAGGAC
TCAAGCTTAAGCCCATGAAGCCTGGGATAGAAGACAATTGGAGGCTGCAAAGTTGGCTTTCACAGTGCAAGCCTTTGATTCCCAATGGGG
GACTCAGGATCAAGACGATCTACCCTGGTCTCCCGGTTGCCAATATTCAGAAGAAGTATTAACAGAAGACATGATTCTCTTCCTTCTTCA
CCTTCTTCCAGTAATACAGTTGGTGTCCACAGTTCCTCTCCTTCCAGCACTAACTCAAGCTCAGGTAGCACAGGTAAACGGAGGAGCATA
TTCCGTACTCCTTCCATTAGCTTCCACCATAAGAAGGGGAGTGAGCCTAAGCAAGAGCCTACCAACCAGAACCTTAGTATTTCAAATGGT
GCTCAACCTGGTCACAGCAATATGCAGAAACTGAGTTTGGAAGAACATATTAAGACCAGGGGAAGACATTCTGTTGGTTTTAGTAGTTCA
CGAAATAAGAAGATAACAAGATCTTTGACAGAGGATTTTGAAAGGGAAAAAGAGCACTCAACTAACAAGAATGTCTTTATAAATTGTCTA
AGTTCTGGCAAAAGTGAAGGGGATGATTCTGGTTTCACAGAAGACCAAACTCGTCGTTCTGTTAAGCAGTCAACAAGGAAGCTACTCCCT
AAATCTTTTTCATCTCACTATAAATTTTCTAAGCCAGTTCTACAGAGCCAATCCATTTCATTGGTACAACAGTCTGAATTCTCATTGGAA
GTTACACAGTACCAAGAGAGAGAACCTGTATTAGTAAGAGCTTCGCCATCCTGTTCTGTGGATGTAACAGAACGGGCAGGAAGCTCTTTA
CAATCTCCTTTGCTTTCTGCTGATCTTACCACAGCTCAGACACCTTCAGAATTTTTAGCCTTGACTGAAGATTCTGTGTCTGAAATGGAT
GCATTTTCTAAAAGTGGAAGCATGGCATCCCACTGTGACAACTTTGGCCACAATGATTCTACCTCTCAGATGTCCCTCAATTCTGCTGCT
GTTACAAAGACAACAACAGAACTTACGGGAACTGTTCCCTGTGCAATTATGTCTCCTGGGAAATATAGGTTAGAGGGTCAATGTAGCACT
GAATCTAATTCATTACCGGAAACCTCTGCTGCTAATCAGAAGGAAGTGTTATTACAAATTGCTGAACTACCTGCTACAAGTGTGAGCCAC
TCAGAGAGTAACCTACCAGCAGATAGTGAAAGAGAAGAAAATATAGGGTTACAAAATGGTGAAACAATGCTGGGGACAAACTCCCCAAGG
AAACTTGGATTTTATGAGCAACATAAAGCAATAGCGGAACATGTAAAAGGGATCCATCCTATTTCAGATTCAAAGATAATACCTACTTCT
GGTGATCATCATATTTTTAACAAAACATCACATGGATATGAAGCAAATCCTGCCAAAGTTCTTGCCAGTAGTCTCAGTCCATTTCGTGAA
GGAAGATTTATAGAGAGGAGACTGCGATCCTCGTCAGAAGGCACTGCAGGGAGTAGCAGAATGATTTTGAAACCGAAAGATGGAAATATA
GAAGAAGTTAATAGTTTAAGAAAGCAAAGAGCAGGTTCTTCATCTTCAAAAATGAACAGTTTGGATGTTTTGAATAATTTGGGATCTTGT
GAACTGGATGAAGATGATCTAATGCTTGATCTTGAATTTTTAGAGGAACAGAGTCTTCACCCTTCTGTTTGCCGGGAGGACTCATATCAC
TCTGTCGTCTCATGTGCCGCAGTAGTTCTTACTCCTATGGAACCAATGATAGAAATGAAGAAAAGAGAAGAACCAGAATTTCCTGAGCCT
TCCAAACAAGGACATAGATGAAAATCTCTTGTTTTGAACGAAGATTTTAAAGAACTCAACTTTCCAGCATCCTCCTCTGTTCTAACCACT
TCAGAAATATATGCAGCTGTGATACTTGTAGATTTATATTTAGCAAAATGTTAGCATGTATGACAAGACAATGAGAGTAATTGCTTGACA
ACAACCTATGCACCAGGTATTTAACATTAACTTTGGAAACAAAAATGTACAATTAAGTAAAGTCAACATATGCAAAATACTGTACATTGT
GAACAGAAGTTTAATTCATAGTAATTTCACTCTCTGCATTGACTTATGAGATAATTAATGATTAAACTATTAATGATAAAAATAATGCAT
TTGTATTGTTCATAATATCATGTGCACTTCAAGAAAATGGAATGCTACTCTTTTGTGGTTTACGTGTATTATTTTCAATATCTTAATACC

>In-frame_ENST00000432775_ENST00000418378_TCGA-VQ-AA68-01A_CCSER1_chr4_91389505_+_SPARCL1_chr4_88394955_length(amino acids)=578AA_start in transcript=354_stop in transcript=2090
MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSIS
NGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSE
MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPF
REGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS

--------------------------------------------------------------
>In-frame_ENST00000432775_ENST00000503414_TCGA-VQ-AA68-01A_CCSER1_chr4_91389505_+_SPARCL1_chr4_88394955_length(transcript)=2464nt_BP=2078nt
GTTACCATCGAGACCGGGGCTGTGTATGCTCGAGGTGCAGGGAGCTAATGTATAAGGAGTTAAATGAACTCTTGCTGCTGCCAAATATGT
TGTTATCACTAACTGCACCGCTGCTGTCATTAGTGCTGCTGCCAACACTGCAAGCCCTGCTGCTGCCAGTGCCAATTCTGCTGATGCCTT
GGGCTCTCCATGTCCCAGGGTGATTCCATAGACAAGCAGCTGCTTTTAGATTTCACTTGCTCATTACCTGTAGATCCTTTGCCTTAGGAC
TCAAGCTTAAGCCCATGAAGCCTGGGATAGAAGACAATTGGAGGCTGCAAAGTTGGCTTTCACAGTGCAAGCCTTTGATTCCCAATGGGG
GACTCAGGATCAAGACGATCTACCCTGGTCTCCCGGTTGCCAATATTCAGAAGAAGTATTAACAGAAGACATGATTCTCTTCCTTCTTCA
CCTTCTTCCAGTAATACAGTTGGTGTCCACAGTTCCTCTCCTTCCAGCACTAACTCAAGCTCAGGTAGCACAGGTAAACGGAGGAGCATA
TTCCGTACTCCTTCCATTAGCTTCCACCATAAGAAGGGGAGTGAGCCTAAGCAAGAGCCTACCAACCAGAACCTTAGTATTTCAAATGGT
GCTCAACCTGGTCACAGCAATATGCAGAAACTGAGTTTGGAAGAACATATTAAGACCAGGGGAAGACATTCTGTTGGTTTTAGTAGTTCA
CGAAATAAGAAGATAACAAGATCTTTGACAGAGGATTTTGAAAGGGAAAAAGAGCACTCAACTAACAAGAATGTCTTTATAAATTGTCTA
AGTTCTGGCAAAAGTGAAGGGGATGATTCTGGTTTCACAGAAGACCAAACTCGTCGTTCTGTTAAGCAGTCAACAAGGAAGCTACTCCCT
AAATCTTTTTCATCTCACTATAAATTTTCTAAGCCAGTTCTACAGAGCCAATCCATTTCATTGGTACAACAGTCTGAATTCTCATTGGAA
GTTACACAGTACCAAGAGAGAGAACCTGTATTAGTAAGAGCTTCGCCATCCTGTTCTGTGGATGTAACAGAACGGGCAGGAAGCTCTTTA
CAATCTCCTTTGCTTTCTGCTGATCTTACCACAGCTCAGACACCTTCAGAATTTTTAGCCTTGACTGAAGATTCTGTGTCTGAAATGGAT
GCATTTTCTAAAAGTGGAAGCATGGCATCCCACTGTGACAACTTTGGCCACAATGATTCTACCTCTCAGATGTCCCTCAATTCTGCTGCT
GTTACAAAGACAACAACAGAACTTACGGGAACTGTTCCCTGTGCAATTATGTCTCCTGGGAAATATAGGTTAGAGGGTCAATGTAGCACT
GAATCTAATTCATTACCGGAAACCTCTGCTGCTAATCAGAAGGAAGTGTTATTACAAATTGCTGAACTACCTGCTACAAGTGTGAGCCAC
TCAGAGAGTAACCTACCAGCAGATAGTGAAAGAGAAGAAAATATAGGGTTACAAAATGGTGAAACAATGCTGGGGACAAACTCCCCAAGG
AAACTTGGATTTTATGAGCAACATAAAGCAATAGCGGAACATGTAAAAGGGATCCATCCTATTTCAGATTCAAAGATAATACCTACTTCT
GGTGATCATCATATTTTTAACAAAACATCACATGGATATGAAGCAAATCCTGCCAAAGTTCTTGCCAGTAGTCTCAGTCCATTTCGTGAA
GGAAGATTTATAGAGAGGAGACTGCGATCCTCGTCAGAAGGCACTGCAGGGAGTAGCAGAATGATTTTGAAACCGAAAGATGGAAATATA
GAAGAAGTTAATAGTTTAAGAAAGCAAAGAGCAGGTTCTTCATCTTCAAAAATGAACAGTTTGGATGTTTTGAATAATTTGGGATCTTGT
GAACTGGATGAAGATGATCTAATGCTTGATCTTGAATTTTTAGAGGAACAGAGTCTTCACCCTTCTGTTTGCCGGGAGGACTCATATCAC
TCTGTCGTCTCATGTGCCGCAGTAGTTCTTACTCCTATGGAACCAATGATAGAAATGAAGAAAAGAGAAGAACCAGAATTTCCTGAGCCT
TCCAAACAAGGACATAGATGAAAATCTCTTGTTTTGAACGAAGATTTTAAAGAACTCAACTTTCCAGCATCCTCCTCTGTTCTAACCACT
TCAGAAATATATGCAGCTGTGATACTTGTAGATTTATATTTAGCAAAATGTTAGCATGTATGACAAGACAATGAGAGTAATTGCTTGACA
ACAACCTATGCACCAGGTATTTAACATTAACTTTGGAAACAAAAATGTACAATTAAGTAAAGTCAACATATGCAAAATACTGTACATTGT
GAACAGAAGTTTAATTCATAGTAATTTCACTCTCTGCATTGACTTATGAGATAATTAATGATTAAACTATTAATGATAAAAATAATGCAT

>In-frame_ENST00000432775_ENST00000503414_TCGA-VQ-AA68-01A_CCSER1_chr4_91389505_+_SPARCL1_chr4_88394955_length(amino acids)=578AA_start in transcript=354_stop in transcript=2090
MGDSGSRRSTLVSRLPIFRRSINRRHDSLPSSPSSSNTVGVHSSSPSSTNSSSGSTGKRRSIFRTPSISFHHKKGSEPKQEPTNQNLSIS
NGAQPGHSNMQKLSLEEHIKTRGRHSVGFSSSRNKKITRSLTEDFEREKEHSTNKNVFINCLSSGKSEGDDSGFTEDQTRRSVKQSTRKL
LPKSFSSHYKFSKPVLQSQSISLVQQSEFSLEVTQYQEREPVLVRASPSCSVDVTERAGSSLQSPLLSADLTTAQTPSEFLALTEDSVSE
MDAFSKSGSMASHCDNFGHNDSTSQMSLNSAAVTKTTTELTGTVPCAIMSPGKYRLEGQCSTESNSLPETSAANQKEVLLQIAELPATSV
SHSESNLPADSEREENIGLQNGETMLGTNSPRKLGFYEQHKAIAEHVKGIHPISDSKIIPTSGDHHIFNKTSHGYEANPAKVLASSLSPF
REGRFIERRLRSSSEGTAGSSRMILKPKDGNIEEVNSLRKQRAGSSSSKMNSLDVLNNLGSCELDEDDLMLDLEFLEEQSLHPSVCREDS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CCSER1-SPARCL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CCSER1-SPARCL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CCSER1-SPARCL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCSER1C0009171Cocaine Abuse1CTD_human
HgeneCCSER1C0236736Cocaine-Related Disorders1CTD_human
HgeneCCSER1C0600427Cocaine Dependence1CTD_human
TgeneSPARCL1C0014175Endometriosis1CTD_human
TgeneSPARCL1C0014544Epilepsy1CTD_human
TgeneSPARCL1C0086237Epilepsy, Cryptogenic1CTD_human
TgeneSPARCL1C0236018Aura1CTD_human
TgeneSPARCL1C0269102Endometrioma1CTD_human
TgeneSPARCL1C0751111Awakening Epilepsy1CTD_human