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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CCT3-RAC1 (FusionGDB2 ID:14346)

Fusion Gene Summary for CCT3-RAC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CCT3-RAC1
Fusion gene ID: 14346
HgeneTgene
Gene symbol

CCT3

RAC1

Gene ID

7203

6035

Gene namechaperonin containing TCP1 subunit 3ribonuclease A family member 1, pancreatic
SynonymsCCT-gamma|CCTG|PIG48|TCP-1-gamma|TRIC5RAC1|RIB1|RNS1
Cytomap

1q22

14q11.2

Type of geneprotein-codingprotein-coding
DescriptionT-complex protein 1 subunit gammaT-complex protein 1, gamma subunitTCP1 (t-complex-1) ring complex, polypeptide 5chaperonin containing TCP1, subunit 3 (gamma)hTRiC5ribonuclease pancreaticHP-RNaseRIB-1RNase 1RNase ARNase upI-1ribonuclease 1ribonuclease A C1ribonuclease, RNase A family, 1 (pancreatic)
Modification date2020032720200313
UniProtAcc

P49368

.
Ensembl transtripts involved in fusion geneENST00000295688, ENST00000368259, 
ENST00000368261, ENST00000472765, 
ENST00000368256, 		ENST00000348035, 
ENST00000356142, ENST00000488373, 
Fusion gene scores* DoF score24 X 18 X 12=518417 X 10 X 5=850
# samples 2818
** MAII scorelog2(28/5184*10)=-4.21056698593966
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/850*10)=-2.23946593469539
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CCT3 [Title/Abstract] AND RAC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCCT3(156287279)-RAC1(6442050), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRAC1

GO:0051607

defense response to virus

9826755

TgeneRAC1

GO:0090501

RNA phosphodiester bond hydrolysis

9826755


check buttonFusion gene breakpoints across CCT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across RAC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACB114948CCT3chr1

156287279

-RAC1chr7

6442050

+


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Fusion Gene ORF analysis for CCT3-RAC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000295688ENST00000348035CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3CDSENST00000295688ENST00000356142CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3UTRENST00000295688ENST00000488373CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3CDSENST00000368259ENST00000348035CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3CDSENST00000368259ENST00000356142CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3UTRENST00000368259ENST00000488373CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3CDSENST00000368261ENST00000348035CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3CDSENST00000368261ENST00000356142CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3UTRENST00000368261ENST00000488373CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3CDSENST00000472765ENST00000348035CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3CDSENST00000472765ENST00000356142CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3UTRENST00000472765ENST00000488373CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3CDSENST00000368256ENST00000348035CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3CDSENST00000368256ENST00000356142CCT3chr1

156287279

-RAC1chr7

6442050

+
intron-3UTRENST00000368256ENST00000488373CCT3chr1

156287279

-RAC1chr7

6442050

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CCT3-RAC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CCT3-RAC1


check button Go to

FGviewer for the breakpoints of :-:

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CCT3

P49368

.
FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000305}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CCT3-RAC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CCT3-RAC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CCT3-RAC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CCT3-RAC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCCT3C0019193Hepatitis, Toxic1CTD_human
HgeneCCT3C0019693HIV Infections1CTD_human
HgeneCCT3C0860207Drug-Induced Liver Disease1CTD_human
HgeneCCT3C1262760Hepatitis, Drug-Induced1CTD_human
HgeneCCT3C3658290Drug-Induced Acute Liver Injury1CTD_human
HgeneCCT3C4277682Chemical and Drug Induced Liver Injury1CTD_human
HgeneCCT3C4279912Chemically-Induced Liver Toxicity1CTD_human
HgeneCCT3C4505456HIV Coinfection1CTD_human
TgeneRAC1C0011570Mental Depression2PSYGENET
TgeneRAC1C0011581Depressive disorder2PSYGENET
TgeneRAC1C0007193Cardiomyopathy, Dilated1CTD_human
TgeneRAC1C0007621Neoplastic Cell Transformation1CTD_human
TgeneRAC1C0011849Diabetes Mellitus1CTD_human
TgeneRAC1C0018801Heart failure1CTD_human
TgeneRAC1C0018802Congestive heart failure1CTD_human
TgeneRAC1C0023212Left-Sided Heart Failure1CTD_human
TgeneRAC1C0023895Liver diseases1CTD_human
TgeneRAC1C0025202melanoma1CGI;CTD_human
TgeneRAC1C0027627Neoplasm Metastasis1CTD_human
TgeneRAC1C0086565Liver Dysfunction1CTD_human
TgeneRAC1C0235527Heart Failure, Right-Sided1CTD_human
TgeneRAC1C0242698Ventricular Dysfunction, Left1CTD_human
TgeneRAC1C0424605Developmental delay (disorder)1GENOMICS_ENGLAND
TgeneRAC1C0557874Global developmental delay1GENOMICS_ENGLAND
TgeneRAC1C0876994Cardiotoxicity1CTD_human
TgeneRAC1C1449563Cardiomyopathy, Familial Idiopathic1CTD_human
TgeneRAC1C1959583Myocardial Failure1CTD_human
TgeneRAC1C1961112Heart Decompensation1CTD_human
TgeneRAC1C2239176Liver carcinoma1CTD_human
TgeneRAC1C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneRAC1C4540321MENTAL RETARDATION, AUTOSOMAL DOMINANT 481ORPHANET;UNIPROT