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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CD109-NPHP1 (FusionGDB2 ID:14421)

Fusion Gene Summary for CD109-NPHP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CD109-NPHP1
Fusion gene ID: 14421
HgeneTgene
Gene symbol

CD109

NPHP1

Gene ID

135228

4867

Gene nameCD109 moleculenephrocystin 1
SynonymsCPAMD7|p180|r150JBTS4|NPH1|SLSN1
Cytomap

6q13

2q13

Type of geneprotein-codingprotein-coding
DescriptionCD109 antigen150 kDa TGF-beta-1-binding proteinC3 and PZP-like alpha-2-macroglobulin domain-containing protein 7Gov platelet alloantigensactivated T-cell marker CD109platelet-specific Gov antigennephrocystin-1juvenile nephronophthisis 1 proteinnephronophthisis 1 (juvenile)
Modification date2020031320200313
UniProtAcc

Q6YHK3

O15259

Ensembl transtripts involved in fusion geneENST00000422508, ENST00000437994, 
ENST00000287097, ENST00000474094, 
ENST00000316534, ENST00000445609, 
ENST00000393272, ENST00000355301, 
ENST00000417665, ENST00000418527, 
Fusion gene scores* DoF score5 X 5 X 1=252 X 2 X 2=8
# samples 52
** MAII scorelog2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: CD109 [Title/Abstract] AND NPHP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD109(74440297)-NPHP1(110920711), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD109

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

16754747

HgeneCD109

GO:0061045

negative regulation of wound healing

16754747


check buttonFusion gene breakpoints across CD109 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NPHP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AW33075CD109chr6

74440297

+NPHP1chr2

110920711

-


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Fusion Gene ORF analysis for CD109-NPHP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000422508ENST00000316534CD109chr6

74440297

+NPHP1chr2

110920711

-
intron-3CDSENST00000422508ENST00000445609CD109chr6

74440297

+NPHP1chr2

110920711

-
intron-3CDSENST00000422508ENST00000393272CD109chr6

74440297

+NPHP1chr2

110920711

-
intron-3CDSENST00000422508ENST00000355301CD109chr6

74440297

+NPHP1chr2

110920711

-
intron-3CDSENST00000422508ENST00000417665CD109chr6

74440297

+NPHP1chr2

110920711

-
intron-intronENST00000422508ENST00000418527CD109chr6

74440297

+NPHP1chr2

110920711

-
In-frameENST00000437994ENST00000316534CD109chr6

74440297

+NPHP1chr2

110920711

-
In-frameENST00000437994ENST00000445609CD109chr6

74440297

+NPHP1chr2

110920711

-
In-frameENST00000437994ENST00000393272CD109chr6

74440297

+NPHP1chr2

110920711

-
In-frameENST00000437994ENST00000355301CD109chr6

74440297

+NPHP1chr2

110920711

-
In-frameENST00000437994ENST00000417665CD109chr6

74440297

+NPHP1chr2

110920711

-
5CDS-intronENST00000437994ENST00000418527CD109chr6

74440297

+NPHP1chr2

110920711

-
In-frameENST00000287097ENST00000316534CD109chr6

74440297

+NPHP1chr2

110920711

-
In-frameENST00000287097ENST00000445609CD109chr6

74440297

+NPHP1chr2

110920711

-
In-frameENST00000287097ENST00000393272CD109chr6

74440297

+NPHP1chr2

110920711

-
In-frameENST00000287097ENST00000355301CD109chr6

74440297

+NPHP1chr2

110920711

-
In-frameENST00000287097ENST00000417665CD109chr6

74440297

+NPHP1chr2

110920711

-
5CDS-intronENST00000287097ENST00000418527CD109chr6

74440297

+NPHP1chr2

110920711

-
intron-3CDSENST00000474094ENST00000316534CD109chr6

74440297

+NPHP1chr2

110920711

-
intron-3CDSENST00000474094ENST00000445609CD109chr6

74440297

+NPHP1chr2

110920711

-
intron-3CDSENST00000474094ENST00000393272CD109chr6

74440297

+NPHP1chr2

110920711

-
intron-3CDSENST00000474094ENST00000355301CD109chr6

74440297

+NPHP1chr2

110920711

-
intron-3CDSENST00000474094ENST00000417665CD109chr6

74440297

+NPHP1chr2

110920711

-
intron-intronENST00000474094ENST00000418527CD109chr6

74440297

+NPHP1chr2

110920711

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000437994CD109chr674440297+ENST00000316534NPHP1chr2110920711-36819384312200589
ENST00000437994CD109chr674440297+ENST00000445609NPHP1chr2110920711-26569384312200589
ENST00000437994CD109chr674440297+ENST00000393272NPHP1chr2110920711-26539384312197588
ENST00000437994CD109chr674440297+ENST00000355301NPHP1chr2110920711-22819384312197588
ENST00000437994CD109chr674440297+ENST00000417665NPHP1chr2110920711-23869384312302623
ENST00000287097CD109chr674440297+ENST00000316534NPHP1chr2110920711-33626191121881589
ENST00000287097CD109chr674440297+ENST00000445609NPHP1chr2110920711-23376191121881589
ENST00000287097CD109chr674440297+ENST00000393272NPHP1chr2110920711-23346191121878588
ENST00000287097CD109chr674440297+ENST00000355301NPHP1chr2110920711-19626191121878588
ENST00000287097CD109chr674440297+ENST00000417665NPHP1chr2110920711-20676191121983623

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000437994ENST00000316534CD109chr674440297+NPHP1chr2110920711-0.0020391870.9979608
ENST00000437994ENST00000445609CD109chr674440297+NPHP1chr2110920711-0.0022676930.9977323
ENST00000437994ENST00000393272CD109chr674440297+NPHP1chr2110920711-0.0026437090.9973563
ENST00000437994ENST00000355301CD109chr674440297+NPHP1chr2110920711-0.0042127390.9957872
ENST00000437994ENST00000417665CD109chr674440297+NPHP1chr2110920711-0.0048983670.99510163
ENST00000287097ENST00000316534CD109chr674440297+NPHP1chr2110920711-0.0020923250.99790776
ENST00000287097ENST00000445609CD109chr674440297+NPHP1chr2110920711-0.0023610510.99763894
ENST00000287097ENST00000393272CD109chr674440297+NPHP1chr2110920711-0.0027358540.99726415
ENST00000287097ENST00000355301CD109chr674440297+NPHP1chr2110920711-0.0049362350.9950637
ENST00000287097ENST00000417665CD109chr674440297+NPHP1chr2110920711-0.0057317570.9942682

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Fusion Genomic Features for CD109-NPHP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CD109-NPHP1


check button Go to

FGviewer for the breakpoints of chr6:74440297-chr2:110920711

.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD109

Q6YHK3

NPHP1

O15259

FUNCTION: Modulates negatively TGFB1 signaling in keratinocytes. {ECO:0000269|PubMed:16754747}.FUNCTION: Together with BCAR1 it may play a role in the control of epithelial cell polarity (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity). Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling (By similarity). May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly. Required for normal retina development (By similarity). In connecting photoreceptor cilia influences the movement of some IFT proteins such as IFT88 and WDR19. Involved in spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q9QY53}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNPHP1chr6:74440297chr2:110920711ENST00000355301518212_227195.0615.0Compositional biasNote=Glu-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD109chr6:74440297chr2:110920711ENST00000287097+433593_702169.01446.0RegionBait region (approximate)
HgeneCD109chr6:74440297chr2:110920711ENST00000422508+132593_70201369.0RegionBait region (approximate)
HgeneCD109chr6:74440297chr2:110920711ENST00000437994+433593_702169.01429.0RegionBait region (approximate)
TgeneNPHP1chr6:74440297chr2:110920711ENST00000316534720127_150313.0734.0Coiled coilOntology_term=ECO:0000255
TgeneNPHP1chr6:74440297chr2:110920711ENST000003165347203_105313.0734.0Coiled coilOntology_term=ECO:0000255
TgeneNPHP1chr6:74440297chr2:110920711ENST00000355301518127_150195.0615.0Coiled coilOntology_term=ECO:0000255
TgeneNPHP1chr6:74440297chr2:110920711ENST000003553015183_105195.0615.0Coiled coilOntology_term=ECO:0000255
TgeneNPHP1chr6:74440297chr2:110920711ENST00000393272720127_150313.0733.0Coiled coilOntology_term=ECO:0000255
TgeneNPHP1chr6:74440297chr2:110920711ENST000003932727203_105313.0733.0Coiled coilOntology_term=ECO:0000255
TgeneNPHP1chr6:74440297chr2:110920711ENST00000445609720127_150257.0678.0Coiled coilOntology_term=ECO:0000255
TgeneNPHP1chr6:74440297chr2:110920711ENST000004456097203_105257.0678.0Coiled coilOntology_term=ECO:0000255
TgeneNPHP1chr6:74440297chr2:110920711ENST00000316534720116_147313.0734.0Compositional biasNote=Glu-rich
TgeneNPHP1chr6:74440297chr2:110920711ENST00000316534720212_227313.0734.0Compositional biasNote=Glu-rich
TgeneNPHP1chr6:74440297chr2:110920711ENST00000355301518116_147195.0615.0Compositional biasNote=Glu-rich
TgeneNPHP1chr6:74440297chr2:110920711ENST00000393272720116_147313.0733.0Compositional biasNote=Glu-rich
TgeneNPHP1chr6:74440297chr2:110920711ENST00000393272720212_227313.0733.0Compositional biasNote=Glu-rich
TgeneNPHP1chr6:74440297chr2:110920711ENST00000445609720116_147257.0678.0Compositional biasNote=Glu-rich
TgeneNPHP1chr6:74440297chr2:110920711ENST00000445609720212_227257.0678.0Compositional biasNote=Glu-rich
TgeneNPHP1chr6:74440297chr2:110920711ENST00000316534720152_212313.0734.0DomainSH3
TgeneNPHP1chr6:74440297chr2:110920711ENST00000355301518152_212195.0615.0DomainSH3
TgeneNPHP1chr6:74440297chr2:110920711ENST00000393272720152_212313.0733.0DomainSH3
TgeneNPHP1chr6:74440297chr2:110920711ENST00000445609720152_212257.0678.0DomainSH3


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Fusion Gene Sequence for CD109-NPHP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>In-frame_ENST00000437994_ENST00000316534_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(transcript)=3681nt_BP=938nt
ATAGTTGCTATGAATTTCTCCTCACAAGGATGGGCCTGTTTACTCACCCTGGGCATCGTTGGTAGAGCGCTAGTGTAAACAGCCTGAGGA
ACCCGGTGGGCCGGGGAAGTGGGCGCGCTCTGTTCTCCGCGGCCAGCTGGGACGCCGGGCCAGGTGGGGCCGCCTGCGTTTAGCAACTGC
TTTCTCACCCCCTGGATTTGCGATGTTTGCCACAGCAGCGAGAAGCGCCATTGTAATGGGGATGGGAGGGGTGGAGCCTCCAAGTCCTGT
CTCAATTTAGATCTCTCACTCTGCTGTTAGGCGCGCCCATTTCAGATTACTAAACTCGAATTAAGAGGGAAAAAAAATCAGGGAGGAGGT
GGCAAGCCACACCCCACGGTGCCCGCGAACTTCCCCGGCAGCGGACTGTAGCCCAGGCAGACGCCGTCGAGATGCAGGGCCCACCGCTCC
TGACCGCCGCCCACCTCCTCTGCGTGTGCACCGCCGCGCTGGCCGTGGCTCCCGGGCCTCGGTTTCTGGTGACAGCCCCAGGGATCATCA
GGCCCGGAGGAAATGTGACTATTGGGGTGGAGCTTCTGGAACACTGCCCTTCACAGGTGACTGTGAAGGCGGAGCTGCTCAAGACAGCAT
CAAACCTCACTGTCTCTGTCCTGGAAGCAGAAGGAGTCTTTGAAAAAGGCTCTTTTAAGACACTTACTCTTCCATCACTACCTCTGAACA
GTGCAGATGAGATTTATGAGCTACGTGTAACCGGACGTACCCAGGATGAGATTTTATTCTCTAATAGTACCCGCTTATCATTTGAGACCA
AGAGAATATCTGTCTTCATTCAAACAGACAAGGCCTTATACAAGCCAAAGCAAGAAGTGAAGTTTCGCATTGTTACACTCTTCTCAGATT
TTAAGCCTTACAAAACCTCTTTAAACATTCTCATTAAGCAGATAAACACTGTTGATGTGTTAACTACGATGGGAGCTATTCCTGCAGGGT
TCAGGCCTTCCACGCTCTCACAGCTTCTGGAGGAAGGGAATCAATTTCGAGCAAATTACTTCTTACAACCAGAGCTCATGCCTTCACAAC
TGGCCTTCAGAGATCTGATGTGGGATGCTACAGAAGGCACTATTAGGTCGAGACCAAGTCGTATTTCATTGATTCTGACATTATGGAGCT
GTAAAATGATTCCTCTTCCAGGAATGAGCATACAGGTTCTCAGCAGACATGTACGCCTCTGTCTATTTGATGGTAATAAGGTTCTGAGCA
ACATTCATACAGTCAGAGCCACATGGCAACCTAAAAAGCCCAAAACATGGACCTTTTCTCCCCAGGTTACTCGCATCTTACCATGTTTGC
TTGATGGTGATTGCTTTATCAGGTCTAATTCTGCATCTCCAGATCTTGGAATATTATTTGAACTTGGAATTTCTTATATTCGCAATTCAA
CTGGTGAAAGAGGAGAGTTAAGCTGTGGCTGGGTGTTTCTTAAACTTTTTGATGCCAGTGGAGTTCCTATTCCAGCAAAAACTTATGAGC
TTTTCTTGAATGGTGGTACTCCTTATGAAAAAGGTATTGAAGTGGACCCTTCAATATCCAGAAGAGCACACGGCAGTGTTTTCTACCAGA
TTATGACAATGAGAAGGCAGCCTCAACTTCTAGTGAAACTGAGATCCTTGAACAGAAGATCAAGAAATGTACTAAGTCTACTGCCAGAAA
CATTAATTGGAAATATGTGTTCTATTCACTTGTTGATATTTTATCGACAAATTCTTGGAGATGTGCTCCTGAAAGACAGGATGAGCTTGC
AAAGTACTGATTTAATTAGCCATCCCATGCTGGCCACCTTCCCCATGCTCTTGGAGCAGCCTGATGTGATGGATGCTCTCAGGAGTTCGT
GGGCTGGAAAAGAAAGCACATTAAAAAGATCAGAGAAGAGAGACAAAGAGTTCCTGAAGTCCACGTTTCTCCTGGTTTACCATGACTGCG
TGCTCCCACTTCTCCACTCCACACGCCTACCCCCATTCAGGTGGGCAGAAGAAGAGACTGAGACTGCACGGTGGAAAGTTATCACTGACT
TCCTTAAGCAAAACCAAGAAAACCAGGGCGCCCTCCAAGCTCTGCTGTCACCAGACGGAGTTCATGAACCTTTTGACCTTTCAGAGCAGA
CCTATGACTTCTTGGGTGAAATGAGAAAGAATGCAGTGTGACAGTGGCAGCCTCTAGCCCTCAGCTTCCCACGGAATCAGATGGATCCTC
CACGATTACGTGAATAAAATGATGGAACCAAAAATCACTGTCACTTTACAACTTAGGTTTTACTCTTTTCTTTCTACAGACCATATTTTT
AAAGAAATGTTTATACAATAATTTAAATATTTTTTAAAACCATAAAATAAATTTTTATAAGGAATACTGTTATATCTAAATTTAAACAGT
ATTTATTTTTTCAAAAACAGCTACTTAAGTTAATGGTATAGATTTCTATAAAAGCAAGATTTTGTCAAAAACTAAATTTATGATTATTCA
AGAAAGTGAAAAAAACAACCTACAGAATGGGAAAACATATTTGCAAATCATCTAACTGATAAAGGTCTAGTATCCAAAATATTTAAATTT
ATGAGTGTTAATAAAATTTATCTTGTTCAATGAAGAGGAAGTTAAAGTGATCCATTTGAGAAAGTTGTATCACTTAATTCAGTCTGATAC
TTGAATGTGATTTACCCCTAATTAAGTACAAAAACAGAGTCGCTTTTGCCTTTTCAAATCAAGAAAATAAGTGCTCTGTCAAAAGCACAA
AAAGAAACTTTCAGGCACTGGAGAGTGGAGTCGACTCACCCTTTCAGGCCTTGTTGCATCTCAGATAAACCTGTGACTGCTGGTAAAATA
ATGTCCCAAGCCTTTCCTTTTAGTGATAAACAGTAGCAGCCTGCGTTAATTGAGCACCTACTGTGTGTCTGAGCATTTCTCATTAGCCCA
GTTAATCCTCACACCTACTGTAGGAGATAGGTACTGTTGTTTTTTATTACCGCCGAAGAAACAGGCCAGATAAGTGAAGTAATTTGCCTA
AGGTCACAGCTAATAAGTGGCACAGCTAATATTCCCAGTAAAGATACCATGTATAATTTTCTACAACCTAAGATGTTCTGCCTTATCGGG
GCGAACCTTTTAGGATTCCATGTGAAAATAAAATATGAGGAAAAGTTTAACCTAAATAATTAGAATCCCATTAGAGGTACTTTTTTTTGA
TGGCATGCTGCCTTAAAAGAGCCATTTATTTTTAGAGATCTGTCATATTATGAAAGTTCTGGGCTATCTTAGCTAACTTATCCTAAACCC
TTAACCTAAATTTAACTTGAGCCCCAGTCTCAGAAATTAACATGGTATGAAGGTGTTTCCAGGCCAGGCGCGGTGGCTCACGCCTGTAAT
CCCAACACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACACTATCTGTACTAAAAACACA
AAATTAGCTGGGCGTGGTAGTGCGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGTAGAAGAATTGTTTGAACCTGGGAGGTGGAGGT

>In-frame_ENST00000437994_ENST00000316534_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(amino acids)=589AA_start in transcript=431_stop in transcript=2200
MQGPPLLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAEGVFEKGSFKTLTL
PSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKQINTVDVLTTM
GAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFD
GNKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPI
PAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLL
KDRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDCVLPLLHSTRLPPFRWAEEETETAR

--------------------------------------------------------------
>In-frame_ENST00000437994_ENST00000445609_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(transcript)=2656nt_BP=938nt
ATAGTTGCTATGAATTTCTCCTCACAAGGATGGGCCTGTTTACTCACCCTGGGCATCGTTGGTAGAGCGCTAGTGTAAACAGCCTGAGGA
ACCCGGTGGGCCGGGGAAGTGGGCGCGCTCTGTTCTCCGCGGCCAGCTGGGACGCCGGGCCAGGTGGGGCCGCCTGCGTTTAGCAACTGC
TTTCTCACCCCCTGGATTTGCGATGTTTGCCACAGCAGCGAGAAGCGCCATTGTAATGGGGATGGGAGGGGTGGAGCCTCCAAGTCCTGT
CTCAATTTAGATCTCTCACTCTGCTGTTAGGCGCGCCCATTTCAGATTACTAAACTCGAATTAAGAGGGAAAAAAAATCAGGGAGGAGGT
GGCAAGCCACACCCCACGGTGCCCGCGAACTTCCCCGGCAGCGGACTGTAGCCCAGGCAGACGCCGTCGAGATGCAGGGCCCACCGCTCC
TGACCGCCGCCCACCTCCTCTGCGTGTGCACCGCCGCGCTGGCCGTGGCTCCCGGGCCTCGGTTTCTGGTGACAGCCCCAGGGATCATCA
GGCCCGGAGGAAATGTGACTATTGGGGTGGAGCTTCTGGAACACTGCCCTTCACAGGTGACTGTGAAGGCGGAGCTGCTCAAGACAGCAT
CAAACCTCACTGTCTCTGTCCTGGAAGCAGAAGGAGTCTTTGAAAAAGGCTCTTTTAAGACACTTACTCTTCCATCACTACCTCTGAACA
GTGCAGATGAGATTTATGAGCTACGTGTAACCGGACGTACCCAGGATGAGATTTTATTCTCTAATAGTACCCGCTTATCATTTGAGACCA
AGAGAATATCTGTCTTCATTCAAACAGACAAGGCCTTATACAAGCCAAAGCAAGAAGTGAAGTTTCGCATTGTTACACTCTTCTCAGATT
TTAAGCCTTACAAAACCTCTTTAAACATTCTCATTAAGCAGATAAACACTGTTGATGTGTTAACTACGATGGGAGCTATTCCTGCAGGGT
TCAGGCCTTCCACGCTCTCACAGCTTCTGGAGGAAGGGAATCAATTTCGAGCAAATTACTTCTTACAACCAGAGCTCATGCCTTCACAAC
TGGCCTTCAGAGATCTGATGTGGGATGCTACAGAAGGCACTATTAGGTCGAGACCAAGTCGTATTTCATTGATTCTGACATTATGGAGCT
GTAAAATGATTCCTCTTCCAGGAATGAGCATACAGGTTCTCAGCAGACATGTACGCCTCTGTCTATTTGATGGTAATAAGGTTCTGAGCA
ACATTCATACAGTCAGAGCCACATGGCAACCTAAAAAGCCCAAAACATGGACCTTTTCTCCCCAGGTTACTCGCATCTTACCATGTTTGC
TTGATGGTGATTGCTTTATCAGGTCTAATTCTGCATCTCCAGATCTTGGAATATTATTTGAACTTGGAATTTCTTATATTCGCAATTCAA
CTGGTGAAAGAGGAGAGTTAAGCTGTGGCTGGGTGTTTCTTAAACTTTTTGATGCCAGTGGAGTTCCTATTCCAGCAAAAACTTATGAGC
TTTTCTTGAATGGTGGTACTCCTTATGAAAAAGGTATTGAAGTGGACCCTTCAATATCCAGAAGAGCACACGGCAGTGTTTTCTACCAGA
TTATGACAATGAGAAGGCAGCCTCAACTTCTAGTGAAACTGAGATCCTTGAACAGAAGATCAAGAAATGTACTAAGTCTACTGCCAGAAA
CATTAATTGGAAATATGTGTTCTATTCACTTGTTGATATTTTATCGACAAATTCTTGGAGATGTGCTCCTGAAAGACAGGATGAGCTTGC
AAAGTACTGATTTAATTAGCCATCCCATGCTGGCCACCTTCCCCATGCTCTTGGAGCAGCCTGATGTGATGGATGCTCTCAGGAGTTCGT
GGGCTGGAAAAGAAAGCACATTAAAAAGATCAGAGAAGAGAGACAAAGAGTTCCTGAAGTCCACGTTTCTCCTGGTTTACCATGACTGCG
TGCTCCCACTTCTCCACTCCACACGCCTACCCCCATTCAGGTGGGCAGAAGAAGAGACTGAGACTGCACGGTGGAAAGTTATCACTGACT
TCCTTAAGCAAAACCAAGAAAACCAGGGCGCCCTCCAAGCTCTGCTGTCACCAGACGGAGTTCATGAACCTTTTGACCTTTCAGAGCAGA
CCTATGACTTCTTGGGTGAAATGAGAAAGAATGCAGTGTGACAGTGGCAGCCTCTAGCCCTCAGCTTCCCACGGAATCAGATGGATCCTC
CACGATTACGTGAATAAAATGATGGAACCAAAAATCACTGTCACTTTACAACTTAGGTTTTACTCTTTTCTTTCTACAGACCATATTTTT
AAAGAAATGTTTATACAATAATTTAAATATTTTTTAAAACCATAAAATAAATTTTTATAAGGAATACTGTTATATCTAAATTTAAACAGT
ATTTATTTTTTCAAAAACAGCTACTTAAGTTAATGGTATAGATTTCTATAAAAGCAAGATTTTGTCAAAAACTAAATTTATGATTATTCA
AGAAAGTGAAAAAAACAACCTACAGAATGGGAAAACATATTTGCAAATCATCTAACTGATAAAGGTCTAGTATCCAAAATATTTAAATTT

>In-frame_ENST00000437994_ENST00000445609_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(amino acids)=589AA_start in transcript=431_stop in transcript=2200
MQGPPLLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAEGVFEKGSFKTLTL
PSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKQINTVDVLTTM
GAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFD
GNKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPI
PAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLL
KDRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDCVLPLLHSTRLPPFRWAEEETETAR

--------------------------------------------------------------
>In-frame_ENST00000437994_ENST00000393272_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(transcript)=2653nt_BP=938nt
ATAGTTGCTATGAATTTCTCCTCACAAGGATGGGCCTGTTTACTCACCCTGGGCATCGTTGGTAGAGCGCTAGTGTAAACAGCCTGAGGA
ACCCGGTGGGCCGGGGAAGTGGGCGCGCTCTGTTCTCCGCGGCCAGCTGGGACGCCGGGCCAGGTGGGGCCGCCTGCGTTTAGCAACTGC
TTTCTCACCCCCTGGATTTGCGATGTTTGCCACAGCAGCGAGAAGCGCCATTGTAATGGGGATGGGAGGGGTGGAGCCTCCAAGTCCTGT
CTCAATTTAGATCTCTCACTCTGCTGTTAGGCGCGCCCATTTCAGATTACTAAACTCGAATTAAGAGGGAAAAAAAATCAGGGAGGAGGT
GGCAAGCCACACCCCACGGTGCCCGCGAACTTCCCCGGCAGCGGACTGTAGCCCAGGCAGACGCCGTCGAGATGCAGGGCCCACCGCTCC
TGACCGCCGCCCACCTCCTCTGCGTGTGCACCGCCGCGCTGGCCGTGGCTCCCGGGCCTCGGTTTCTGGTGACAGCCCCAGGGATCATCA
GGCCCGGAGGAAATGTGACTATTGGGGTGGAGCTTCTGGAACACTGCCCTTCACAGGTGACTGTGAAGGCGGAGCTGCTCAAGACAGCAT
CAAACCTCACTGTCTCTGTCCTGGAAGCAGAAGGAGTCTTTGAAAAAGGCTCTTTTAAGACACTTACTCTTCCATCACTACCTCTGAACA
GTGCAGATGAGATTTATGAGCTACGTGTAACCGGACGTACCCAGGATGAGATTTTATTCTCTAATAGTACCCGCTTATCATTTGAGACCA
AGAGAATATCTGTCTTCATTCAAACAGACAAGGCCTTATACAAGCCAAAGCAAGAAGTGAAGTTTCGCATTGTTACACTCTTCTCAGATT
TTAAGCCTTACAAAACCTCTTTAAACATTCTCATTAAGATAAACACTGTTGATGTGTTAACTACGATGGGAGCTATTCCTGCAGGGTTCA
GGCCTTCCACGCTCTCACAGCTTCTGGAGGAAGGGAATCAATTTCGAGCAAATTACTTCTTACAACCAGAGCTCATGCCTTCACAACTGG
CCTTCAGAGATCTGATGTGGGATGCTACAGAAGGCACTATTAGGTCGAGACCAAGTCGTATTTCATTGATTCTGACATTATGGAGCTGTA
AAATGATTCCTCTTCCAGGAATGAGCATACAGGTTCTCAGCAGACATGTACGCCTCTGTCTATTTGATGGTAATAAGGTTCTGAGCAACA
TTCATACAGTCAGAGCCACATGGCAACCTAAAAAGCCCAAAACATGGACCTTTTCTCCCCAGGTTACTCGCATCTTACCATGTTTGCTTG
ATGGTGATTGCTTTATCAGGTCTAATTCTGCATCTCCAGATCTTGGAATATTATTTGAACTTGGAATTTCTTATATTCGCAATTCAACTG
GTGAAAGAGGAGAGTTAAGCTGTGGCTGGGTGTTTCTTAAACTTTTTGATGCCAGTGGAGTTCCTATTCCAGCAAAAACTTATGAGCTTT
TCTTGAATGGTGGTACTCCTTATGAAAAAGGTATTGAAGTGGACCCTTCAATATCCAGAAGAGCACACGGCAGTGTTTTCTACCAGATTA
TGACAATGAGAAGGCAGCCTCAACTTCTAGTGAAACTGAGATCCTTGAACAGAAGATCAAGAAATGTACTAAGTCTACTGCCAGAAACAT
TAATTGGAAATATGTGTTCTATTCACTTGTTGATATTTTATCGACAAATTCTTGGAGATGTGCTCCTGAAAGACAGGATGAGCTTGCAAA
GTACTGATTTAATTAGCCATCCCATGCTGGCCACCTTCCCCATGCTCTTGGAGCAGCCTGATGTGATGGATGCTCTCAGGAGTTCGTGGG
CTGGAAAAGAAAGCACATTAAAAAGATCAGAGAAGAGAGACAAAGAGTTCCTGAAGTCCACGTTTCTCCTGGTTTACCATGACTGCGTGC
TCCCACTTCTCCACTCCACACGCCTACCCCCATTCAGGTGGGCAGAAGAAGAGACTGAGACTGCACGGTGGAAAGTTATCACTGACTTCC
TTAAGCAAAACCAAGAAAACCAGGGCGCCCTCCAAGCTCTGCTGTCACCAGACGGAGTTCATGAACCTTTTGACCTTTCAGAGCAGACCT
ATGACTTCTTGGGTGAAATGAGAAAGAATGCAGTGTGACAGTGGCAGCCTCTAGCCCTCAGCTTCCCACGGAATCAGATGGATCCTCCAC
GATTACGTGAATAAAATGATGGAACCAAAAATCACTGTCACTTTACAACTTAGGTTTTACTCTTTTCTTTCTACAGACCATATTTTTAAA
GAAATGTTTATACAATAATTTAAATATTTTTTAAAACCATAAAATAAATTTTTATAAGGAATACTGTTATATCTAAATTTAAACAGTATT
TATTTTTTCAAAAACAGCTACTTAAGTTAATGGTATAGATTTCTATAAAAGCAAGATTTTGTCAAAAACTAAATTTATGATTATTCAAGA
AAGTGAAAAAAACAACCTACAGAATGGGAAAACATATTTGCAAATCATCTAACTGATAAAGGTCTAGTATCCAAAATATTTAAATTTATG

>In-frame_ENST00000437994_ENST00000393272_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(amino acids)=588AA_start in transcript=431_stop in transcript=2197
MQGPPLLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAEGVFEKGSFKTLTL
PSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKINTVDVLTTMG
AIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG
NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPIP
AKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK
DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDCVLPLLHSTRLPPFRWAEEETETARW

--------------------------------------------------------------
>In-frame_ENST00000437994_ENST00000355301_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(transcript)=2281nt_BP=938nt
ATAGTTGCTATGAATTTCTCCTCACAAGGATGGGCCTGTTTACTCACCCTGGGCATCGTTGGTAGAGCGCTAGTGTAAACAGCCTGAGGA
ACCCGGTGGGCCGGGGAAGTGGGCGCGCTCTGTTCTCCGCGGCCAGCTGGGACGCCGGGCCAGGTGGGGCCGCCTGCGTTTAGCAACTGC
TTTCTCACCCCCTGGATTTGCGATGTTTGCCACAGCAGCGAGAAGCGCCATTGTAATGGGGATGGGAGGGGTGGAGCCTCCAAGTCCTGT
CTCAATTTAGATCTCTCACTCTGCTGTTAGGCGCGCCCATTTCAGATTACTAAACTCGAATTAAGAGGGAAAAAAAATCAGGGAGGAGGT
GGCAAGCCACACCCCACGGTGCCCGCGAACTTCCCCGGCAGCGGACTGTAGCCCAGGCAGACGCCGTCGAGATGCAGGGCCCACCGCTCC
TGACCGCCGCCCACCTCCTCTGCGTGTGCACCGCCGCGCTGGCCGTGGCTCCCGGGCCTCGGTTTCTGGTGACAGCCCCAGGGATCATCA
GGCCCGGAGGAAATGTGACTATTGGGGTGGAGCTTCTGGAACACTGCCCTTCACAGGTGACTGTGAAGGCGGAGCTGCTCAAGACAGCAT
CAAACCTCACTGTCTCTGTCCTGGAAGCAGAAGGAGTCTTTGAAAAAGGCTCTTTTAAGACACTTACTCTTCCATCACTACCTCTGAACA
GTGCAGATGAGATTTATGAGCTACGTGTAACCGGACGTACCCAGGATGAGATTTTATTCTCTAATAGTACCCGCTTATCATTTGAGACCA
AGAGAATATCTGTCTTCATTCAAACAGACAAGGCCTTATACAAGCCAAAGCAAGAAGTGAAGTTTCGCATTGTTACACTCTTCTCAGATT
TTAAGCCTTACAAAACCTCTTTAAACATTCTCATTAAGATAAACACTGTTGATGTGTTAACTACGATGGGAGCTATTCCTGCAGGGTTCA
GGCCTTCCACGCTCTCACAGCTTCTGGAGGAAGGGAATCAATTTCGAGCAAATTACTTCTTACAACCAGAGCTCATGCCTTCACAACTGG
CCTTCAGAGATCTGATGTGGGATGCTACAGAAGGCACTATTAGGTCGAGACCAAGTCGTATTTCATTGATTCTGACATTATGGAGCTGTA
AAATGATTCCTCTTCCAGGAATGAGCATACAGGTTCTCAGCAGACATGTACGCCTCTGTCTATTTGATGGTAATAAGGTTCTGAGCAACA
TTCATACAGTCAGAGCCACATGGCAACCTAAAAAGCCCAAAACATGGACCTTTTCTCCCCAGGTTACTCGCATCTTACCATGTTTGCTTG
ATGGTGATTGCTTTATCAGGTCTAATTCTGCATCTCCAGATCTTGGAATATTATTTGAACTTGGAATTTCTTATATTCGCAATTCAACTG
GTGAAAGAGGAGAGTTAAGCTGTGGCTGGGTGTTTCTTAAACTTTTTGATGCCAGTGGAGTTCCTATTCCAGCAAAAACTTATGAGCTTT
TCTTGAATGGTGGTACTCCTTATGAAAAAGGTATTGAAGTGGACCCTTCAATATCCAGAAGAGCACACGGCAGTGTTTTCTACCAGATTA
TGACAATGAGAAGGCAGCCTCAACTTCTAGTGAAACTGAGATCCTTGAACAGAAGATCAAGAAATGTACTAAGTCTACTGCCAGAAACAT
TAATTGGAAATATGTGTTCTATTCACTTGTTGATATTTTATCGACAAATTCTTGGAGATGTGCTCCTGAAAGACAGGATGAGCTTGCAAA
GTACTGATTTAATTAGCCATCCCATGCTGGCCACCTTCCCCATGCTCTTGGAGCAGCCTGATGTGATGGATGCTCTCAGGAGTTCGTGGG
CTGGAAAAGAAAGCACATTAAAAAGATCAGAGAAGAGAGACAAAGAGTTCCTGAAGTCCACGTTTCTCCTGGTTTACCATGACTGCGTGC
TCCCACTTCTCCACTCCACACGCCTACCCCCATTCAGGTGGGCAGAAGAAGAGACTGAGACTGCACGGTGGAAAGTTATCACTGACTTCC
TTAAGCAAAACCAAGAAAACCAGGGCGCCCTCCAAGCTCTGCTGTCACCAGACGGAGTTCATGAACCTTTTGACCTTTCAGAGCAGACCT
ATGACTTCTTGGGTGAAATGAGAAAGAATGCAGTGTGACAGTGGCAGCCTCTAGCCCTCAGCTTCCCACGGAATCAGATGGATCCTCCAC

>In-frame_ENST00000437994_ENST00000355301_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(amino acids)=588AA_start in transcript=431_stop in transcript=2197
MQGPPLLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAEGVFEKGSFKTLTL
PSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKINTVDVLTTMG
AIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG
NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPIP
AKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK
DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDCVLPLLHSTRLPPFRWAEEETETARW

--------------------------------------------------------------
>In-frame_ENST00000437994_ENST00000417665_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(transcript)=2386nt_BP=938nt
ATAGTTGCTATGAATTTCTCCTCACAAGGATGGGCCTGTTTACTCACCCTGGGCATCGTTGGTAGAGCGCTAGTGTAAACAGCCTGAGGA
ACCCGGTGGGCCGGGGAAGTGGGCGCGCTCTGTTCTCCGCGGCCAGCTGGGACGCCGGGCCAGGTGGGGCCGCCTGCGTTTAGCAACTGC
TTTCTCACCCCCTGGATTTGCGATGTTTGCCACAGCAGCGAGAAGCGCCATTGTAATGGGGATGGGAGGGGTGGAGCCTCCAAGTCCTGT
CTCAATTTAGATCTCTCACTCTGCTGTTAGGCGCGCCCATTTCAGATTACTAAACTCGAATTAAGAGGGAAAAAAAATCAGGGAGGAGGT
GGCAAGCCACACCCCACGGTGCCCGCGAACTTCCCCGGCAGCGGACTGTAGCCCAGGCAGACGCCGTCGAGATGCAGGGCCCACCGCTCC
TGACCGCCGCCCACCTCCTCTGCGTGTGCACCGCCGCGCTGGCCGTGGCTCCCGGGCCTCGGTTTCTGGTGACAGCCCCAGGGATCATCA
GGCCCGGAGGAAATGTGACTATTGGGGTGGAGCTTCTGGAACACTGCCCTTCACAGGTGACTGTGAAGGCGGAGCTGCTCAAGACAGCAT
CAAACCTCACTGTCTCTGTCCTGGAAGCAGAAGGAGTCTTTGAAAAAGGCTCTTTTAAGACACTTACTCTTCCATCACTACCTCTGAACA
GTGCAGATGAGATTTATGAGCTACGTGTAACCGGACGTACCCAGGATGAGATTTTATTCTCTAATAGTACCCGCTTATCATTTGAGACCA
AGAGAATATCTGTCTTCATTCAAACAGACAAGGCCTTATACAAGCCAAAGCAAGAAGTGAAGTTTCGCATTGTTACACTCTTCTCAGATT
TTAAGCCTTACAAAACCTCTTTAAACATTCTCATTAAGATAAACACTGTTGATGTGTTAACTACGATGGGAGCTATTCCTGCAGGGTTCA
GGCCTTCCACGCTCTCACAGCTTCTGGAGGAAGGGAATCAATTTCGAGCAAATTACTTCTTACAACCAGAGCTCATGCCTTCACAACTGG
CCTTCAGAGATCTGATGTGGGATGCTACAGAAGGCACTATTAGGTCGAGACCAAGTCGTATTTCATTGATTCTGACATTATGGAGCTGTA
AAATGATTCCTCTTCCAGGAATGAGCATACAGGTTCTCAGCAGACATGTACGCCTCTGTCTATTTGATGGTAATAAGGTTCTGAGCAACA
TTCATACAGTCAGAGCCACATGGCAACCTAAAAAGCCCAAAACATGGACCTTTTCTCCCCAGGTTACTCGCATCTTACCATGTTTGCTTG
ATGGTGATTGCTTTATCAGGTCTAATTCTGCATCTCCAGATCTTGGAATATTATTTGAACTTGGAATTTCTTATATTCGCAATTCAACTG
GTGAAAGAGGAGAGTTAAGCTGTGGCTGGGTGTTTCTTAAACTTTTTGATGCCAGTGGAGTTCCTATTCCAGCAAAAACTTATGAGCTTT
TCTTGAATGGTGGTACTCCTTATGAAAAAGGTATTGAAGTGGACCCTTCAATATCCAGAAGAGCACACGGCAGTGTTTTCTACCAGATTA
TGACAATGAGAAGGCAGCCTCAACTTCTAGTGAAACTGAGATCCTTGAACAGAAGATCAAGAAATGTACTAAGTCTACTGCCAGAAACAT
TAATTGGAAATATGTGTTCTATTCACTTGTTGATATTTTATCGACAAATTCTTGGAGATGTGCTCCTGAAAGACAGGATGAGCTTGCAAA
GTACTGATTTAATTAGCCATCCCATGCTGGCCACCTTCCCCATGCTCTTGGAGCAGCCTGATGTGATGGATGCTCTCAGGAGTTCGTGGG
CTGGAAAAGAAAGCACATTAAAAAGATCAGAGAAGCTCTCAAAGCCTGTATCACCAAGAGAAGGGAAAAAAAAATGGCCTGAGCTGTACC
ATATATTGAAAACAATGCATTGCTCCTGCTTACCTTGCTATAAAATCATGAGAGACAAAGAGTTCCTGAAGTCCACGTTTCTCCTGGTTT
ACCATGACTGCGTGCTCCCACTTCTCCACTCCACACGCCTACCCCCATTCAGGTGGGCAGAAGAAGAGACTGAGACTGCACGGTGGAAAG
TTATCACTGACTTCCTTAAGCAAAACCAAGAAAACCAGGGCGCCCTCCAAGCTCTGCTGTCACCAGACGGAGTTCATGAACCTTTTGACC
TTTCAGAGCAGACCTATGACTTCTTGGGTGAAATGAGAAAGAATGCAGTGTGACAGTGGCAGCCTCTAGCCCTCAGCTTCCCACGGAATC

>In-frame_ENST00000437994_ENST00000417665_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(amino acids)=623AA_start in transcript=431_stop in transcript=2302
MQGPPLLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAEGVFEKGSFKTLTL
PSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKINTVDVLTTMG
AIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG
NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPIP
AKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK
DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKLSKPVSPREGKKKWPELYHILKTMHCSCLPCYKIMRDKEFLK

--------------------------------------------------------------
>In-frame_ENST00000287097_ENST00000316534_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(transcript)=3362nt_BP=619nt
CTAAACTCGAATTAAGAGGGAAAAAAAATCAGGGAGGAGGTGGCAAGCCACACCCCACGGTGCCCGCGAACTTCCCCGGCAGCGGACTGT
AGCCCAGGCAGACGCCGTCGAGATGCAGGGCCCACCGCTCCTGACCGCCGCCCACCTCCTCTGCGTGTGCACCGCCGCGCTGGCCGTGGC
TCCCGGGCCTCGGTTTCTGGTGACAGCCCCAGGGATCATCAGGCCCGGAGGAAATGTGACTATTGGGGTGGAGCTTCTGGAACACTGCCC
TTCACAGGTGACTGTGAAGGCGGAGCTGCTCAAGACAGCATCAAACCTCACTGTCTCTGTCCTGGAAGCAGAAGGAGTCTTTGAAAAAGG
CTCTTTTAAGACACTTACTCTTCCATCACTACCTCTGAACAGTGCAGATGAGATTTATGAGCTACGTGTAACCGGACGTACCCAGGATGA
GATTTTATTCTCTAATAGTACCCGCTTATCATTTGAGACCAAGAGAATATCTGTCTTCATTCAAACAGACAAGGCCTTATACAAGCCAAA
GCAAGAAGTGAAGTTTCGCATTGTTACACTCTTCTCAGATTTTAAGCCTTACAAAACCTCTTTAAACATTCTCATTAAGCAGATAAACAC
TGTTGATGTGTTAACTACGATGGGAGCTATTCCTGCAGGGTTCAGGCCTTCCACGCTCTCACAGCTTCTGGAGGAAGGGAATCAATTTCG
AGCAAATTACTTCTTACAACCAGAGCTCATGCCTTCACAACTGGCCTTCAGAGATCTGATGTGGGATGCTACAGAAGGCACTATTAGGTC
GAGACCAAGTCGTATTTCATTGATTCTGACATTATGGAGCTGTAAAATGATTCCTCTTCCAGGAATGAGCATACAGGTTCTCAGCAGACA
TGTACGCCTCTGTCTATTTGATGGTAATAAGGTTCTGAGCAACATTCATACAGTCAGAGCCACATGGCAACCTAAAAAGCCCAAAACATG
GACCTTTTCTCCCCAGGTTACTCGCATCTTACCATGTTTGCTTGATGGTGATTGCTTTATCAGGTCTAATTCTGCATCTCCAGATCTTGG
AATATTATTTGAACTTGGAATTTCTTATATTCGCAATTCAACTGGTGAAAGAGGAGAGTTAAGCTGTGGCTGGGTGTTTCTTAAACTTTT
TGATGCCAGTGGAGTTCCTATTCCAGCAAAAACTTATGAGCTTTTCTTGAATGGTGGTACTCCTTATGAAAAAGGTATTGAAGTGGACCC
TTCAATATCCAGAAGAGCACACGGCAGTGTTTTCTACCAGATTATGACAATGAGAAGGCAGCCTCAACTTCTAGTGAAACTGAGATCCTT
GAACAGAAGATCAAGAAATGTACTAAGTCTACTGCCAGAAACATTAATTGGAAATATGTGTTCTATTCACTTGTTGATATTTTATCGACA
AATTCTTGGAGATGTGCTCCTGAAAGACAGGATGAGCTTGCAAAGTACTGATTTAATTAGCCATCCCATGCTGGCCACCTTCCCCATGCT
CTTGGAGCAGCCTGATGTGATGGATGCTCTCAGGAGTTCGTGGGCTGGAAAAGAAAGCACATTAAAAAGATCAGAGAAGAGAGACAAAGA
GTTCCTGAAGTCCACGTTTCTCCTGGTTTACCATGACTGCGTGCTCCCACTTCTCCACTCCACACGCCTACCCCCATTCAGGTGGGCAGA
AGAAGAGACTGAGACTGCACGGTGGAAAGTTATCACTGACTTCCTTAAGCAAAACCAAGAAAACCAGGGCGCCCTCCAAGCTCTGCTGTC
ACCAGACGGAGTTCATGAACCTTTTGACCTTTCAGAGCAGACCTATGACTTCTTGGGTGAAATGAGAAAGAATGCAGTGTGACAGTGGCA
GCCTCTAGCCCTCAGCTTCCCACGGAATCAGATGGATCCTCCACGATTACGTGAATAAAATGATGGAACCAAAAATCACTGTCACTTTAC
AACTTAGGTTTTACTCTTTTCTTTCTACAGACCATATTTTTAAAGAAATGTTTATACAATAATTTAAATATTTTTTAAAACCATAAAATA
AATTTTTATAAGGAATACTGTTATATCTAAATTTAAACAGTATTTATTTTTTCAAAAACAGCTACTTAAGTTAATGGTATAGATTTCTAT
AAAAGCAAGATTTTGTCAAAAACTAAATTTATGATTATTCAAGAAAGTGAAAAAAACAACCTACAGAATGGGAAAACATATTTGCAAATC
ATCTAACTGATAAAGGTCTAGTATCCAAAATATTTAAATTTATGAGTGTTAATAAAATTTATCTTGTTCAATGAAGAGGAAGTTAAAGTG
ATCCATTTGAGAAAGTTGTATCACTTAATTCAGTCTGATACTTGAATGTGATTTACCCCTAATTAAGTACAAAAACAGAGTCGCTTTTGC
CTTTTCAAATCAAGAAAATAAGTGCTCTGTCAAAAGCACAAAAAGAAACTTTCAGGCACTGGAGAGTGGAGTCGACTCACCCTTTCAGGC
CTTGTTGCATCTCAGATAAACCTGTGACTGCTGGTAAAATAATGTCCCAAGCCTTTCCTTTTAGTGATAAACAGTAGCAGCCTGCGTTAA
TTGAGCACCTACTGTGTGTCTGAGCATTTCTCATTAGCCCAGTTAATCCTCACACCTACTGTAGGAGATAGGTACTGTTGTTTTTTATTA
CCGCCGAAGAAACAGGCCAGATAAGTGAAGTAATTTGCCTAAGGTCACAGCTAATAAGTGGCACAGCTAATATTCCCAGTAAAGATACCA
TGTATAATTTTCTACAACCTAAGATGTTCTGCCTTATCGGGGCGAACCTTTTAGGATTCCATGTGAAAATAAAATATGAGGAAAAGTTTA
ACCTAAATAATTAGAATCCCATTAGAGGTACTTTTTTTTGATGGCATGCTGCCTTAAAAGAGCCATTTATTTTTAGAGATCTGTCATATT
ATGAAAGTTCTGGGCTATCTTAGCTAACTTATCCTAAACCCTTAACCTAAATTTAACTTGAGCCCCAGTCTCAGAAATTAACATGGTATG
AAGGTGTTTCCAGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAACACTTTGGGAGGCCGAGGTGGGTGGATCACCTGAGGTCAGGAGT
TTGAGACCAGCCTGGCCAACACTATCTGTACTAAAAACACAAAATTAGCTGGGCGTGGTAGTGCGTGCCTGTAATCCCAGCTACTTGGGA
GGCTGAGGTAGAAGAATTGTTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCAAGATCGTGCCATTGCACTCCAGCCTAGGCAACAAGAG

>In-frame_ENST00000287097_ENST00000316534_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(amino acids)=589AA_start in transcript=112_stop in transcript=1881
MQGPPLLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAEGVFEKGSFKTLTL
PSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKQINTVDVLTTM
GAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFD
GNKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPI
PAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLL
KDRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDCVLPLLHSTRLPPFRWAEEETETAR

--------------------------------------------------------------
>In-frame_ENST00000287097_ENST00000445609_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(transcript)=2337nt_BP=619nt
CTAAACTCGAATTAAGAGGGAAAAAAAATCAGGGAGGAGGTGGCAAGCCACACCCCACGGTGCCCGCGAACTTCCCCGGCAGCGGACTGT
AGCCCAGGCAGACGCCGTCGAGATGCAGGGCCCACCGCTCCTGACCGCCGCCCACCTCCTCTGCGTGTGCACCGCCGCGCTGGCCGTGGC
TCCCGGGCCTCGGTTTCTGGTGACAGCCCCAGGGATCATCAGGCCCGGAGGAAATGTGACTATTGGGGTGGAGCTTCTGGAACACTGCCC
TTCACAGGTGACTGTGAAGGCGGAGCTGCTCAAGACAGCATCAAACCTCACTGTCTCTGTCCTGGAAGCAGAAGGAGTCTTTGAAAAAGG
CTCTTTTAAGACACTTACTCTTCCATCACTACCTCTGAACAGTGCAGATGAGATTTATGAGCTACGTGTAACCGGACGTACCCAGGATGA
GATTTTATTCTCTAATAGTACCCGCTTATCATTTGAGACCAAGAGAATATCTGTCTTCATTCAAACAGACAAGGCCTTATACAAGCCAAA
GCAAGAAGTGAAGTTTCGCATTGTTACACTCTTCTCAGATTTTAAGCCTTACAAAACCTCTTTAAACATTCTCATTAAGCAGATAAACAC
TGTTGATGTGTTAACTACGATGGGAGCTATTCCTGCAGGGTTCAGGCCTTCCACGCTCTCACAGCTTCTGGAGGAAGGGAATCAATTTCG
AGCAAATTACTTCTTACAACCAGAGCTCATGCCTTCACAACTGGCCTTCAGAGATCTGATGTGGGATGCTACAGAAGGCACTATTAGGTC
GAGACCAAGTCGTATTTCATTGATTCTGACATTATGGAGCTGTAAAATGATTCCTCTTCCAGGAATGAGCATACAGGTTCTCAGCAGACA
TGTACGCCTCTGTCTATTTGATGGTAATAAGGTTCTGAGCAACATTCATACAGTCAGAGCCACATGGCAACCTAAAAAGCCCAAAACATG
GACCTTTTCTCCCCAGGTTACTCGCATCTTACCATGTTTGCTTGATGGTGATTGCTTTATCAGGTCTAATTCTGCATCTCCAGATCTTGG
AATATTATTTGAACTTGGAATTTCTTATATTCGCAATTCAACTGGTGAAAGAGGAGAGTTAAGCTGTGGCTGGGTGTTTCTTAAACTTTT
TGATGCCAGTGGAGTTCCTATTCCAGCAAAAACTTATGAGCTTTTCTTGAATGGTGGTACTCCTTATGAAAAAGGTATTGAAGTGGACCC
TTCAATATCCAGAAGAGCACACGGCAGTGTTTTCTACCAGATTATGACAATGAGAAGGCAGCCTCAACTTCTAGTGAAACTGAGATCCTT
GAACAGAAGATCAAGAAATGTACTAAGTCTACTGCCAGAAACATTAATTGGAAATATGTGTTCTATTCACTTGTTGATATTTTATCGACA
AATTCTTGGAGATGTGCTCCTGAAAGACAGGATGAGCTTGCAAAGTACTGATTTAATTAGCCATCCCATGCTGGCCACCTTCCCCATGCT
CTTGGAGCAGCCTGATGTGATGGATGCTCTCAGGAGTTCGTGGGCTGGAAAAGAAAGCACATTAAAAAGATCAGAGAAGAGAGACAAAGA
GTTCCTGAAGTCCACGTTTCTCCTGGTTTACCATGACTGCGTGCTCCCACTTCTCCACTCCACACGCCTACCCCCATTCAGGTGGGCAGA
AGAAGAGACTGAGACTGCACGGTGGAAAGTTATCACTGACTTCCTTAAGCAAAACCAAGAAAACCAGGGCGCCCTCCAAGCTCTGCTGTC
ACCAGACGGAGTTCATGAACCTTTTGACCTTTCAGAGCAGACCTATGACTTCTTGGGTGAAATGAGAAAGAATGCAGTGTGACAGTGGCA
GCCTCTAGCCCTCAGCTTCCCACGGAATCAGATGGATCCTCCACGATTACGTGAATAAAATGATGGAACCAAAAATCACTGTCACTTTAC
AACTTAGGTTTTACTCTTTTCTTTCTACAGACCATATTTTTAAAGAAATGTTTATACAATAATTTAAATATTTTTTAAAACCATAAAATA
AATTTTTATAAGGAATACTGTTATATCTAAATTTAAACAGTATTTATTTTTTCAAAAACAGCTACTTAAGTTAATGGTATAGATTTCTAT
AAAAGCAAGATTTTGTCAAAAACTAAATTTATGATTATTCAAGAAAGTGAAAAAAACAACCTACAGAATGGGAAAACATATTTGCAAATC

>In-frame_ENST00000287097_ENST00000445609_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(amino acids)=589AA_start in transcript=112_stop in transcript=1881
MQGPPLLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAEGVFEKGSFKTLTL
PSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKQINTVDVLTTM
GAIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFD
GNKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPI
PAKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLL
KDRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDCVLPLLHSTRLPPFRWAEEETETAR

--------------------------------------------------------------
>In-frame_ENST00000287097_ENST00000393272_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(transcript)=2334nt_BP=619nt
CTAAACTCGAATTAAGAGGGAAAAAAAATCAGGGAGGAGGTGGCAAGCCACACCCCACGGTGCCCGCGAACTTCCCCGGCAGCGGACTGT
AGCCCAGGCAGACGCCGTCGAGATGCAGGGCCCACCGCTCCTGACCGCCGCCCACCTCCTCTGCGTGTGCACCGCCGCGCTGGCCGTGGC
TCCCGGGCCTCGGTTTCTGGTGACAGCCCCAGGGATCATCAGGCCCGGAGGAAATGTGACTATTGGGGTGGAGCTTCTGGAACACTGCCC
TTCACAGGTGACTGTGAAGGCGGAGCTGCTCAAGACAGCATCAAACCTCACTGTCTCTGTCCTGGAAGCAGAAGGAGTCTTTGAAAAAGG
CTCTTTTAAGACACTTACTCTTCCATCACTACCTCTGAACAGTGCAGATGAGATTTATGAGCTACGTGTAACCGGACGTACCCAGGATGA
GATTTTATTCTCTAATAGTACCCGCTTATCATTTGAGACCAAGAGAATATCTGTCTTCATTCAAACAGACAAGGCCTTATACAAGCCAAA
GCAAGAAGTGAAGTTTCGCATTGTTACACTCTTCTCAGATTTTAAGCCTTACAAAACCTCTTTAAACATTCTCATTAAGATAAACACTGT
TGATGTGTTAACTACGATGGGAGCTATTCCTGCAGGGTTCAGGCCTTCCACGCTCTCACAGCTTCTGGAGGAAGGGAATCAATTTCGAGC
AAATTACTTCTTACAACCAGAGCTCATGCCTTCACAACTGGCCTTCAGAGATCTGATGTGGGATGCTACAGAAGGCACTATTAGGTCGAG
ACCAAGTCGTATTTCATTGATTCTGACATTATGGAGCTGTAAAATGATTCCTCTTCCAGGAATGAGCATACAGGTTCTCAGCAGACATGT
ACGCCTCTGTCTATTTGATGGTAATAAGGTTCTGAGCAACATTCATACAGTCAGAGCCACATGGCAACCTAAAAAGCCCAAAACATGGAC
CTTTTCTCCCCAGGTTACTCGCATCTTACCATGTTTGCTTGATGGTGATTGCTTTATCAGGTCTAATTCTGCATCTCCAGATCTTGGAAT
ATTATTTGAACTTGGAATTTCTTATATTCGCAATTCAACTGGTGAAAGAGGAGAGTTAAGCTGTGGCTGGGTGTTTCTTAAACTTTTTGA
TGCCAGTGGAGTTCCTATTCCAGCAAAAACTTATGAGCTTTTCTTGAATGGTGGTACTCCTTATGAAAAAGGTATTGAAGTGGACCCTTC
AATATCCAGAAGAGCACACGGCAGTGTTTTCTACCAGATTATGACAATGAGAAGGCAGCCTCAACTTCTAGTGAAACTGAGATCCTTGAA
CAGAAGATCAAGAAATGTACTAAGTCTACTGCCAGAAACATTAATTGGAAATATGTGTTCTATTCACTTGTTGATATTTTATCGACAAAT
TCTTGGAGATGTGCTCCTGAAAGACAGGATGAGCTTGCAAAGTACTGATTTAATTAGCCATCCCATGCTGGCCACCTTCCCCATGCTCTT
GGAGCAGCCTGATGTGATGGATGCTCTCAGGAGTTCGTGGGCTGGAAAAGAAAGCACATTAAAAAGATCAGAGAAGAGAGACAAAGAGTT
CCTGAAGTCCACGTTTCTCCTGGTTTACCATGACTGCGTGCTCCCACTTCTCCACTCCACACGCCTACCCCCATTCAGGTGGGCAGAAGA
AGAGACTGAGACTGCACGGTGGAAAGTTATCACTGACTTCCTTAAGCAAAACCAAGAAAACCAGGGCGCCCTCCAAGCTCTGCTGTCACC
AGACGGAGTTCATGAACCTTTTGACCTTTCAGAGCAGACCTATGACTTCTTGGGTGAAATGAGAAAGAATGCAGTGTGACAGTGGCAGCC
TCTAGCCCTCAGCTTCCCACGGAATCAGATGGATCCTCCACGATTACGTGAATAAAATGATGGAACCAAAAATCACTGTCACTTTACAAC
TTAGGTTTTACTCTTTTCTTTCTACAGACCATATTTTTAAAGAAATGTTTATACAATAATTTAAATATTTTTTAAAACCATAAAATAAAT
TTTTATAAGGAATACTGTTATATCTAAATTTAAACAGTATTTATTTTTTCAAAAACAGCTACTTAAGTTAATGGTATAGATTTCTATAAA
AGCAAGATTTTGTCAAAAACTAAATTTATGATTATTCAAGAAAGTGAAAAAAACAACCTACAGAATGGGAAAACATATTTGCAAATCATC

>In-frame_ENST00000287097_ENST00000393272_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(amino acids)=588AA_start in transcript=112_stop in transcript=1878
MQGPPLLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAEGVFEKGSFKTLTL
PSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKINTVDVLTTMG
AIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG
NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPIP
AKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK
DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDCVLPLLHSTRLPPFRWAEEETETARW

--------------------------------------------------------------
>In-frame_ENST00000287097_ENST00000355301_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(transcript)=1962nt_BP=619nt
CTAAACTCGAATTAAGAGGGAAAAAAAATCAGGGAGGAGGTGGCAAGCCACACCCCACGGTGCCCGCGAACTTCCCCGGCAGCGGACTGT
AGCCCAGGCAGACGCCGTCGAGATGCAGGGCCCACCGCTCCTGACCGCCGCCCACCTCCTCTGCGTGTGCACCGCCGCGCTGGCCGTGGC
TCCCGGGCCTCGGTTTCTGGTGACAGCCCCAGGGATCATCAGGCCCGGAGGAAATGTGACTATTGGGGTGGAGCTTCTGGAACACTGCCC
TTCACAGGTGACTGTGAAGGCGGAGCTGCTCAAGACAGCATCAAACCTCACTGTCTCTGTCCTGGAAGCAGAAGGAGTCTTTGAAAAAGG
CTCTTTTAAGACACTTACTCTTCCATCACTACCTCTGAACAGTGCAGATGAGATTTATGAGCTACGTGTAACCGGACGTACCCAGGATGA
GATTTTATTCTCTAATAGTACCCGCTTATCATTTGAGACCAAGAGAATATCTGTCTTCATTCAAACAGACAAGGCCTTATACAAGCCAAA
GCAAGAAGTGAAGTTTCGCATTGTTACACTCTTCTCAGATTTTAAGCCTTACAAAACCTCTTTAAACATTCTCATTAAGATAAACACTGT
TGATGTGTTAACTACGATGGGAGCTATTCCTGCAGGGTTCAGGCCTTCCACGCTCTCACAGCTTCTGGAGGAAGGGAATCAATTTCGAGC
AAATTACTTCTTACAACCAGAGCTCATGCCTTCACAACTGGCCTTCAGAGATCTGATGTGGGATGCTACAGAAGGCACTATTAGGTCGAG
ACCAAGTCGTATTTCATTGATTCTGACATTATGGAGCTGTAAAATGATTCCTCTTCCAGGAATGAGCATACAGGTTCTCAGCAGACATGT
ACGCCTCTGTCTATTTGATGGTAATAAGGTTCTGAGCAACATTCATACAGTCAGAGCCACATGGCAACCTAAAAAGCCCAAAACATGGAC
CTTTTCTCCCCAGGTTACTCGCATCTTACCATGTTTGCTTGATGGTGATTGCTTTATCAGGTCTAATTCTGCATCTCCAGATCTTGGAAT
ATTATTTGAACTTGGAATTTCTTATATTCGCAATTCAACTGGTGAAAGAGGAGAGTTAAGCTGTGGCTGGGTGTTTCTTAAACTTTTTGA
TGCCAGTGGAGTTCCTATTCCAGCAAAAACTTATGAGCTTTTCTTGAATGGTGGTACTCCTTATGAAAAAGGTATTGAAGTGGACCCTTC
AATATCCAGAAGAGCACACGGCAGTGTTTTCTACCAGATTATGACAATGAGAAGGCAGCCTCAACTTCTAGTGAAACTGAGATCCTTGAA
CAGAAGATCAAGAAATGTACTAAGTCTACTGCCAGAAACATTAATTGGAAATATGTGTTCTATTCACTTGTTGATATTTTATCGACAAAT
TCTTGGAGATGTGCTCCTGAAAGACAGGATGAGCTTGCAAAGTACTGATTTAATTAGCCATCCCATGCTGGCCACCTTCCCCATGCTCTT
GGAGCAGCCTGATGTGATGGATGCTCTCAGGAGTTCGTGGGCTGGAAAAGAAAGCACATTAAAAAGATCAGAGAAGAGAGACAAAGAGTT
CCTGAAGTCCACGTTTCTCCTGGTTTACCATGACTGCGTGCTCCCACTTCTCCACTCCACACGCCTACCCCCATTCAGGTGGGCAGAAGA
AGAGACTGAGACTGCACGGTGGAAAGTTATCACTGACTTCCTTAAGCAAAACCAAGAAAACCAGGGCGCCCTCCAAGCTCTGCTGTCACC
AGACGGAGTTCATGAACCTTTTGACCTTTCAGAGCAGACCTATGACTTCTTGGGTGAAATGAGAAAGAATGCAGTGTGACAGTGGCAGCC

>In-frame_ENST00000287097_ENST00000355301_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(amino acids)=588AA_start in transcript=112_stop in transcript=1878
MQGPPLLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAEGVFEKGSFKTLTL
PSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKINTVDVLTTMG
AIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG
NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPIP
AKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK
DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKRDKEFLKSTFLLVYHDCVLPLLHSTRLPPFRWAEEETETARW

--------------------------------------------------------------
>In-frame_ENST00000287097_ENST00000417665_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(transcript)=2067nt_BP=619nt
CTAAACTCGAATTAAGAGGGAAAAAAAATCAGGGAGGAGGTGGCAAGCCACACCCCACGGTGCCCGCGAACTTCCCCGGCAGCGGACTGT
AGCCCAGGCAGACGCCGTCGAGATGCAGGGCCCACCGCTCCTGACCGCCGCCCACCTCCTCTGCGTGTGCACCGCCGCGCTGGCCGTGGC
TCCCGGGCCTCGGTTTCTGGTGACAGCCCCAGGGATCATCAGGCCCGGAGGAAATGTGACTATTGGGGTGGAGCTTCTGGAACACTGCCC
TTCACAGGTGACTGTGAAGGCGGAGCTGCTCAAGACAGCATCAAACCTCACTGTCTCTGTCCTGGAAGCAGAAGGAGTCTTTGAAAAAGG
CTCTTTTAAGACACTTACTCTTCCATCACTACCTCTGAACAGTGCAGATGAGATTTATGAGCTACGTGTAACCGGACGTACCCAGGATGA
GATTTTATTCTCTAATAGTACCCGCTTATCATTTGAGACCAAGAGAATATCTGTCTTCATTCAAACAGACAAGGCCTTATACAAGCCAAA
GCAAGAAGTGAAGTTTCGCATTGTTACACTCTTCTCAGATTTTAAGCCTTACAAAACCTCTTTAAACATTCTCATTAAGATAAACACTGT
TGATGTGTTAACTACGATGGGAGCTATTCCTGCAGGGTTCAGGCCTTCCACGCTCTCACAGCTTCTGGAGGAAGGGAATCAATTTCGAGC
AAATTACTTCTTACAACCAGAGCTCATGCCTTCACAACTGGCCTTCAGAGATCTGATGTGGGATGCTACAGAAGGCACTATTAGGTCGAG
ACCAAGTCGTATTTCATTGATTCTGACATTATGGAGCTGTAAAATGATTCCTCTTCCAGGAATGAGCATACAGGTTCTCAGCAGACATGT
ACGCCTCTGTCTATTTGATGGTAATAAGGTTCTGAGCAACATTCATACAGTCAGAGCCACATGGCAACCTAAAAAGCCCAAAACATGGAC
CTTTTCTCCCCAGGTTACTCGCATCTTACCATGTTTGCTTGATGGTGATTGCTTTATCAGGTCTAATTCTGCATCTCCAGATCTTGGAAT
ATTATTTGAACTTGGAATTTCTTATATTCGCAATTCAACTGGTGAAAGAGGAGAGTTAAGCTGTGGCTGGGTGTTTCTTAAACTTTTTGA
TGCCAGTGGAGTTCCTATTCCAGCAAAAACTTATGAGCTTTTCTTGAATGGTGGTACTCCTTATGAAAAAGGTATTGAAGTGGACCCTTC
AATATCCAGAAGAGCACACGGCAGTGTTTTCTACCAGATTATGACAATGAGAAGGCAGCCTCAACTTCTAGTGAAACTGAGATCCTTGAA
CAGAAGATCAAGAAATGTACTAAGTCTACTGCCAGAAACATTAATTGGAAATATGTGTTCTATTCACTTGTTGATATTTTATCGACAAAT
TCTTGGAGATGTGCTCCTGAAAGACAGGATGAGCTTGCAAAGTACTGATTTAATTAGCCATCCCATGCTGGCCACCTTCCCCATGCTCTT
GGAGCAGCCTGATGTGATGGATGCTCTCAGGAGTTCGTGGGCTGGAAAAGAAAGCACATTAAAAAGATCAGAGAAGCTCTCAAAGCCTGT
ATCACCAAGAGAAGGGAAAAAAAAATGGCCTGAGCTGTACCATATATTGAAAACAATGCATTGCTCCTGCTTACCTTGCTATAAAATCAT
GAGAGACAAAGAGTTCCTGAAGTCCACGTTTCTCCTGGTTTACCATGACTGCGTGCTCCCACTTCTCCACTCCACACGCCTACCCCCATT
CAGGTGGGCAGAAGAAGAGACTGAGACTGCACGGTGGAAAGTTATCACTGACTTCCTTAAGCAAAACCAAGAAAACCAGGGCGCCCTCCA
AGCTCTGCTGTCACCAGACGGAGTTCATGAACCTTTTGACCTTTCAGAGCAGACCTATGACTTCTTGGGTGAAATGAGAAAGAATGCAGT

>In-frame_ENST00000287097_ENST00000417665_W33075_CD109_chr6_74440297_+_NPHP1_chr2_110920711_length(amino acids)=623AA_start in transcript=112_stop in transcript=1983
MQGPPLLTAAHLLCVCTAALAVAPGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAEGVFEKGSFKTLTL
PSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTDKALYKPKQEVKFRIVTLFSDFKPYKTSLNILIKINTVDVLTTMG
AIPAGFRPSTLSQLLEEGNQFRANYFLQPELMPSQLAFRDLMWDATEGTIRSRPSRISLILTLWSCKMIPLPGMSIQVLSRHVRLCLFDG
NKVLSNIHTVRATWQPKKPKTWTFSPQVTRILPCLLDGDCFIRSNSASPDLGILFELGISYIRNSTGERGELSCGWVFLKLFDASGVPIP
AKTYELFLNGGTPYEKGIEVDPSISRRAHGSVFYQIMTMRRQPQLLVKLRSLNRRSRNVLSLLPETLIGNMCSIHLLIFYRQILGDVLLK
DRMSLQSTDLISHPMLATFPMLLEQPDVMDALRSSWAGKESTLKRSEKLSKPVSPREGKKKWPELYHILKTMHCSCLPCYKIMRDKEFLK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CD109-NPHP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CD109-NPHP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CD109-NPHP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD109C0009402Colorectal Carcinoma2CTD_human;UNIPROT
HgeneCD109C0009404Colorectal Neoplasms2CTD_human
HgeneCD109C0006142Malignant neoplasm of breast1CTD_human
HgeneCD109C0678222Breast Carcinoma1CTD_human
HgeneCD109C1257931Mammary Neoplasms, Human1CTD_human
HgeneCD109C1458155Mammary Neoplasms1CTD_human
HgeneCD109C4704874Mammary Carcinoma, Human1CTD_human
TgeneNPHP1C1846790JOUBERT SYNDROME 4 (disorder)5CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneNPHP1C4551979Nephronophthisis 15CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNPHP1C0403553Renal dysplasia and retinal aplasia (disorder)3CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneNPHP1C4551559Senior-Loken Syndrome 13CTD_human;GENOMICS_ENGLAND
TgeneNPHP1C0687120Nephronophthisis2GENOMICS_ENGLAND
TgeneNPHP1C0752166Bardet-Biedl Syndrome1ORPHANET