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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CD2AP-CDC5L (FusionGDB2 ID:14486)

Fusion Gene Summary for CD2AP-CDC5L

Fusion gene summary

Fusion gene information	Fusion gene name: CD2AP-CDC5L
	Fusion gene ID: 14486
		Hgene	Tgene
	Gene symbol	CD2AP	CDC5L
	Gene ID	23607	988
	Gene name	CD2 associated protein	cell division cycle 5 like
	Synonyms	CMS	CDC5\|CDC5-LIKE\|CEF1\|PCDC5RP\|dJ319D22.1
	Cytomap	6p12.3	6p21.1
	Type of gene	protein-coding	protein-coding
	Description	CD2-associated proteinCas ligand with multiple Src homology 3 (SH3) domainsadapter protein CMScas ligand with multiple SH3 domains	cell division cycle 5-like proteinCDC5 cell division cycle 5-likeCdc5-related proteindJ319D22.1 (CDC5-like protein)pombe cdc5-related protein
	Modification date	20200327	20200313
	UniProtAcc	.	Q99459
	Ensembl transtripts involved in fusion gene	ENST00000359314, ENST00000486693,	ENST00000371477,
Fusion gene scores	* DoF score	18 X 10 X 12=2160	8 X 6 X 6=288
	# samples	20	8
	** MAII score	log2(20/2160*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CD2AP [Title/Abstract] AND CDC5L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CD2AP(47471176)-CDC5L(44413392), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CDC5L	GO:0000398	mRNA splicing, via spliceosome	28076346
Tgene	CDC5L	GO:0045944	positive regulation of transcription by RNA polymerase II	11082045

Fusion gene breakpoints across CD2AP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CDC5L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-FP-8210-01A	CD2AP	chr6	47471176	+	CDC5L	chr6	44413392	+

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Fusion Gene ORF analysis for CD2AP-CDC5L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000359314	ENST00000371477	CD2AP	chr6	47471176	+	CDC5L	chr6	44413392	+
intron-3CDS	ENST00000486693	ENST00000371477	CD2AP	chr6	47471176	+	CDC5L	chr6	44413392	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000359314

CD2AP

chr6

47471176

ENST00000371477

CDC5L

chr6

44413392

4654

621

456

938

160

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000359314	ENST00000371477	CD2AP	chr6	47471176	+	CDC5L	chr6	44413392	+	0.001821943	0.9981781

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Fusion Genomic Features for CD2AP-CDC5L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CD2AP	chr6	47471176	+	CDC5L	chr6	44413391	+	1.39E-06	0.99999857
CD2AP	chr6	47471176	+	CDC5L	chr6	44413391	+	1.39E-06	0.99999857

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CD2AP-CDC5L

Go to
FGviewer for the breakpoints of chr6:47471176-chr6:44413392
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CDC5L Q99459
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28502770, PubMed:28076346, PubMed:29361316, PubMed:29360106, PubMed:29301961, PubMed:30728453, PubMed:30705154). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). {ECO:0000269\|PubMed:10570151, ECO:0000269\|PubMed:11082045, ECO:0000269\|PubMed:11101529, ECO:0000269\|PubMed:11544257, ECO:0000269\|PubMed:11991638, ECO:0000269\|PubMed:12927788, ECO:0000269\|PubMed:18583928, ECO:0000269\|PubMed:20176811, ECO:0000269\|PubMed:24332808, ECO:0000269\|PubMed:28076346, ECO:0000269\|PubMed:28502770, ECO:0000269\|PubMed:29301961, ECO:0000269\|PubMed:29360106, ECO:0000269\|PubMed:29361316, ECO:0000269\|PubMed:30705154, ECO:0000269\|PubMed:30728453, ECO:0000269\|PubMed:9038199, ECO:0000269\|PubMed:9468527, ECO:0000269\|PubMed:9632794}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CDC5L

chr6:47471176

chr6:44413392

ENST00000371477

764_802

697.0

803.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CD2AP

chr6:47471176

chr6:44413392

ENST00000359314

577_638

55.0

640.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CD2AP

chr6:47471176

chr6:44413392

ENST00000359314

336_422

55.0

640.0

Compositional bias

Note=Pro-rich

Hgene

CD2AP

chr6:47471176

chr6:44413392

ENST00000359314

108_167

55.0

640.0

Domain

SH3 2

Hgene

CD2AP

chr6:47471176

chr6:44413392

ENST00000359314

1_59

55.0

640.0

Domain

SH3 1%3B truncated

Hgene

CD2AP

chr6:47471176

chr6:44413392

ENST00000359314

269_330

55.0

640.0

Domain

SH3 3

Hgene

CD2AP

chr6:47471176

chr6:44413392

ENST00000359314

336_352

55.0

640.0

Motif

SH3-binding

Hgene

CD2AP

chr6:47471176

chr6:44413392

ENST00000359314

378_397

55.0

640.0

Motif

SH3-binding

Hgene

CD2AP

chr6:47471176

chr6:44413392

ENST00000359314

410_422

55.0

640.0

Motif

SH3-binding

Tgene

CDC5L

chr6:47471176

chr6:44413392

ENST00000371477

142_245

697.0

803.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CDC5L

chr6:47471176

chr6:44413392

ENST00000371477

676_701

697.0

803.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CDC5L

chr6:47471176

chr6:44413392

ENST00000371477

31_54

697.0

803.0

DNA binding

H-T-H motif

Tgene

CDC5L

chr6:47471176

chr6:44413392

ENST00000371477

82_104

697.0

803.0

DNA binding

H-T-H motif

Tgene

CDC5L

chr6:47471176

chr6:44413392

ENST00000371477

1_56

697.0

803.0

Domain

HTH myb-type 1

Tgene

CDC5L

chr6:47471176

chr6:44413392

ENST00000371477

57_108

697.0

803.0

Domain

HTH myb-type 2

Tgene

CDC5L

chr6:47471176

chr6:44413392

ENST00000371477

165_271

697.0

803.0

Motif

Nuclear localization signal

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Fusion Gene Sequence for CD2AP-CDC5L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>In-frame_ENST00000359314_ENST00000371477_TCGA-FP-8210-01A_CD2AP_chr6_47471176_+_CDC5L_chr6_44413392_length(transcript)=4654nt_BP=621nt
CTCTGTCTGGGTCCCCACCTTAGTCTACGGTGTCGCCTTTTCTAACTGCGAGTGCTAAGGAAGAGGCGAGGGGCGGGCTCCGAGGCTAGG
CGGGCGCTCGGGGTTGGAGCCGAGGGTCTGGGCAAACCGGTGGGTCCCTCCCCACTGCGGGAGCGGCCAGGGTGGGAAAACCGCGGTCGG
GCGGGCGGGGTAGGGCCCTCCCGCCGCCGTGGCTCCTGGGGAGGCCAGGGGTGAGGAGCTGTCGCCGCCTTTGCCTCTGCCTCGAGGGCC
GCGCTGAAGAGACTGGTAGGAGAGCGCCGCGGGCGGATGGAGGCGACTCTTCGCCCCGCCTGAGCTCAGGAGGGGCTAGCGCGGAGCGCG
GGTCCCGCCTCCAGCCGCGGGAGCGGCCGCGCGAGCCACCACTGGAGGAGGAGGAGGAGGAGCGGACGTCGGCTTCTCCCCGCGGGAGCC
CCCAGCATGGTTGACTATATTGTGGAGTATGACTATGATGCTGTACATGATGATGAATTAACTATTCGAGTTGGAGAAATCATCAGGAAT
GTGAAAAAGCTACAGGAGGAAGGGTGGCTGGAAGGAGAACTAAATGGGAGAAGAGGAATGTTCCCTGACAATTTCGTTAAGATAAACAGG
GGTCACATGACGACAGAAGCCAAGAGGGCTGCAAAGATGGAAAAGAAGATGAAAATTTTGCTTGGGGGTTACCAGTCTCGTGCTATGGGG
CTCATGAAACAGTTGAATGACTTATGGGACCAAATTGAACAGGCTCACTTGGAGTTACGCACTTTTGAAGAACTCAAGAAACATGAAGAT
TCTGCTATTCCCCGGAGGCTAGAGTGTCTAAAAGAAGACGTTCAGCGACAACAAGAAAGAGAAAAGGAACTTCAACATAGATATGCTGAT
TTGCTGCTGGAGAAAGAGACTTTAAAGTCAAAATTCTGAAGTACAGTTTATATTCTGTCACAGGATTAATTAATTGCCGGTTTTCATACT
CTAGAAGGCTGAAACTGATGTTTATCTTCATTGACAAATTTACCCACCATCTGTGGTTTTTCAGTTGTTTATTTTAAATGATATCGATCT
TACACATTCTGTGTATAAAGACCTTAACTCCACAGGACGGACATTTTAGAGTTTAAATTATTAAGGCTATCATTCTTTTAGTAATGTCAT
ATTTGCAAACTTTTTTAGTTTTGGCCTTTAATTTAAAAAGCCTAATTTTAAAGTGCTGCCTGTGAGTAACTCTTGAATAAAAACAAAATA
TAAAAAATTGAGAATGTAGCCTTTTGTTTGAAGTAATTAGATACTTAAGAGTGCCTGCAAACCAGCAGCTATGTACTCTGTGTCATATTT
AATGAGTAACTCTTGGGTAATCAAAATGGTGATGCAGTATCTTAAACACTTAAGAGGCAGTTCTTTGTGGCTTTGTTAGTTTCAGCAAAG
AGTGGTCATTTCTGTATACACTGACAAGTTAGATTAACTTTTTAGTACCTCAAATTTTTTTTTTGTTAATATCACTTTAAAGAAGGTCTC
TTGTCTGCCAGCTACTTAAATAATTTATGGGTCAGGGCTTAAAAGATTTAACTTCCTTGCCCCATTATTTTCTTATAAGTATTTTTTGAC
AAAGGCATTTTAAAAGTTAATTTCAAGAAGGCCATCAAACTTAAAGCTCTATGTTTAGCCTAAGAAGTCAGTTACATCAGTGTAGAATTT
GGGGAATGGATAGAGGTGGAGATATTTAATTTTATATAATTCATATAAATTGATTTAGTTACAGTATCAGTTGGCTACAAGCTCATTATA
GACTAGCAATGTTTTGACATCACCAAAAACGTTTGCCCAGTCTTAGAATACTAGGGACTATAGGAAGGGAAGGGATTCATTCATTCATTC
GATATTGAATGTATACCCTGTGCCAGAGTCTTAGAGAGAGAACAACAAACAAAATAGGCCTAGTTCTTGTTTAGTAGAGCTTATAGTCTT
TTGAGAATGACAGACAATTAAAATCCAAATGTTTATTTGGTGATTCTTATGTGTCAGACACTTAAGTGTTGGGAGATAAGCAGTTATTAA
GACAGAGTTCTTGCTCTCATGGAGGTGACATTAGTGGGGAGGAGATACTAAGTATGTCCAGGGAAAGTATCAGACCATGAGTTTTAGATT
CTGTGGAGGAAATTAAAGTAGGGTGATTATGAGATAGTGAATGAGTGGCTATTTTAGACTGGACGATCAAAGAGACCTCTTGGAAGGCAG
CTATGCTCACCACTATACCACTGCACTGTGCCGCACCGTACCACTATAAGCTGCACGGCCAAAGAGACCTCTTAAAGAAGTAACATTTAA
GATAACATGTGATTGACATTTTAGAATGGGCTATCCTTGTGAGATTCAAGGAAAGAACATCCTAGGTGGAGTGAATAGCAAACATAAAGC
CTCTTTTGTATGTTTGAGGAACAAAAAGGACAATGCAGCTAGAGTGTCAAGAATGGCATTTCTGTATATAAGACCTCGTTGTATAGAGCC
ACATAAATAAGGCTATAATAAGGAATTTGGATCTTACTTTAAATATGATAAGAATCGATGAGAAGATCTAAGCAAAGGAATGACATGATC
AGATTTGGTTTTAGAAACATCACTATCTCCTTAGTGTGTAAAATCTCACCAGGCTGGAGATAGGGAAGCCAGTCCAATTAGGAGCCTGAT
GCAGTGATCCAGACAAAAAAATAATAGTGATTCTAACTAGAGTCCAGGTAATAGTAGTGGAGATATGTGGAGAGACATGATAGGTATATA
CTTAATAGTCTTATCAGACGATAAATTGATATTTTCCTGGTGTGTAGTCACTTAATTCAAATACTTTTTTCAGTAAGTTCTGGGTTTTCT
AGGAAAAACTTCAGTATCATCAGTGAATAATGATAGTGTTTCTTCTGATAGTTTTATTTCACTTTTATTGCATGTTTTGTTATCTGAAAT
GTTTAGGACAATGTTAACAATAATGATGTTAGACATTTTTTTTTCTTATTTTAATGGGAATGTCCATAGTTTTAAGTTTGCTGTTGGGAG
TTAGATAGTCTTTATCTGAAAGACAGTGTCTCTCTTTTAGTTTTTAAAGAGTTTGAATTAGAAATGGCTCTGGAACTTTAAACAGTATAC
CATTTGGGCATCTATTAAAGCATTCATATAATTGTTCTCATTTGATGTTTTGATGAGGTATATTAATAGATTTTCCCACATTAAATCATC
TTTGCACTCCTGGAATCAGGTAGATTAATTTTTAAAAGAAATTTTAAAGGATTTATAGTTTATTTGCACTTTTTGTAGACTTGAATTATA
TGGATTTAAAAGTTGATCTAATATTAATAAAGGCTCACTTTGTTTTCAAAATTTGAAGTAATTCACATACTTATAGCCTAAAAAAATCGG
CAGGAATTACAAAATTTCAAAACTGGCACATTGTAAACTGCATATGCATTTGCCAGGTAGTGGTGCCACTTGAAATGGTGAACAGACACA
CTGTTATCCTTTGTCAGTATCCTGTAAAGCCCAGGATTCTTTACCAGCACCATACAGCGATTTTGGTGACTATTTTAACATTCACACTGA
GGCCAGGGGTGGTGAGTCATGCCTGTAATCCTAGCACTTTGGGAGGCCAAGGTGGGAGGATCATTTGAGCTCAGGAGTTCAAGATTAGCC
TGGGTAACATAGTGAGACCCTGTCTCTATTAAAAAATAATAATAAAAATAACATTCACATTGGTATTGTTCACTAAGGTATTGGTTGTTA
AGGCATTCATTAAGGTATTGTTAAAACTTGTGTTAAGCATGTTAAAGTCTCAGTAACTTTGGGATAGAAATAAAATGTGATAAAAAGCTG
AAAGAAACCACCACAAGGGAGAGTCCTTTTTGAAATATTAGAGACATAATGCTGTCTAATAAAAAACGACATCAAAGAAAAACTACACTA
CAGTGACTGCAGACTTAATGTTGGCCAACCATGCATCCTCCCTAGAAATGCATTTGAATTTGATTTACTAATCTTTTATTTAGGAAATTT
ACATTTTTACATTAGTGAGATTGGTCTTTTGGGCTATTGTACTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTGCTCTCTCACCCAGGCT
GGAGTGCAGTAGTGCAATCTTGGCCCACTGCAACCTCTGCCTCCTGGGCTCGAGTGATTCTCTGCCTCAGCCTTCCAAGTAGCTGGGACT
ACAGGCATGTGCCACCGCACCTGGCTAATTTTTGTGTTTTTAGTAGAGATGGGGTTTTGCTATGTTGGCCAGGCTGGTCTTGAATTCCTG
ACCTCAGGTGATCCACCTACCTCGGCCTCCCAAAGTGCTAGAATTACAGGTGTGAGCCACCATGCCCAGCCTGGTTATTGTATTTTGATA
TTGGGATTTTGCTAGCTCTCTAAAGTAAATAGGATAACTGTATATCTTTTTCTGTGCATTAAGCAGTTATAACATGGGAATGATTTGTTC
ATGAAAGGTTGAAAGTCTGTACTTACAGAACTTTTGAGTTCACAGTGCTTTCTGGAAATAATTTCTTTATAACTGTCAGTTTCTTTTGTG

>In-frame_ENST00000359314_ENST00000371477_TCGA-FP-8210-01A_CD2AP_chr6_47471176_+_CDC5L_chr6_44413392_length(amino acids)=160AA_start in transcript=456_stop in transcript=938
MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CD2AP-CDC5L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	CDC5L	chr6:47471176	chr6:44413392	ENST00000371477		13	16	706_800	697.0	803.0	PLRG1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CD2AP	chr6:47471176	chr6:44413392	ENST00000359314	+	2	18	1_175	55.0	640.0	ANLN and localization to the midbody
Tgene	CDC5L	chr6:47471176	chr6:44413392	ENST00000371477		13	16	501_659	697.0	803.0	DAPK3
Tgene	CDC5L	chr6:47471176	chr6:44413392	ENST00000371477		13	16	260_606	697.0	803.0	PPP1R8

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CD2AP-CDC5L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CD2AP-CDC5L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CD2AP	C0002395	Alzheimer's Disease	3	CTD_human
Hgene	CD2AP	C0011265	Presenile dementia	3	CTD_human
Hgene	CD2AP	C0276496	Familial Alzheimer Disease (FAD)	3	CTD_human
Hgene	CD2AP	C0494463	Alzheimer Disease, Late Onset	3	CTD_human
Hgene	CD2AP	C0546126	Acute Confusional Senile Dementia	3	CTD_human
Hgene	CD2AP	C0750900	Alzheimer's Disease, Focal Onset	3	CTD_human
Hgene	CD2AP	C0750901	Alzheimer Disease, Early Onset	3	CTD_human
Hgene	CD2AP	C1842982	FOCAL SEGMENTAL GLOMERULOSCLEROSIS 3, SUSCEPTIBILITY TO	2	GENOMICS_ENGLAND
Hgene	CD2AP	C1868672	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	1	ORPHANET