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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CD63-VARS2 (FusionGDB2 ID:14639)

Fusion Gene Summary for CD63-VARS2

Fusion gene summary

Fusion gene information	Fusion gene name: CD63-VARS2
	Fusion gene ID: 14639
		Hgene	Tgene
	Gene symbol	CD63	VARS2
	Gene ID	967	57176
	Gene name	CD63 molecule	valyl-tRNA synthetase 2, mitochondrial
	Synonyms	LAMP-3\|ME491\|MLA1\|OMA81H\|TSPAN30	COXPD20\|VALRS\|VARS2L\|VARSL
	Cytomap	12q13.2	6p21.33
	Type of gene	protein-coding	protein-coding
	Description	CD63 antigenCD63 antigen (melanoma 1 antigen)granulophysinlysosomal-associated membrane protein 3lysosome-associated membrane glycoprotein 3melanoma-associated antigen ME491melanoma-associated antigen MLA1ocular melanoma-associated antigentetraspa	valine--tRNA ligase, mitochondrialvaline tRNA ligase 2, mitochondrial (putative)valyl-tRNA synthetase like
	Modification date	20200327	20200313
	UniProtAcc	P08962	.
	Ensembl transtripts involved in fusion gene	ENST00000548898, ENST00000552067, ENST00000420846, ENST00000548160, ENST00000546939, ENST00000552692, ENST00000549117, ENST00000257857, ENST00000552754, ENST00000550776,	ENST00000542001, ENST00000416670, ENST00000321897, ENST00000541562, ENST00000476162, ENST00000547340, ENST00000450090, ENST00000549458, ENST00000475174, ENST00000550773, ENST00000383540, ENST00000552560, ENST00000489340, ENST00000551709, ENST00000415079, ENST00000546854, ENST00000462929,
Fusion gene scores	* DoF score	23 X 19 X 9=3933	3 X 3 X 3=27
	# samples	23	3
	** MAII score	log2(23/3933*10)=-4.09592441999854 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CD63 [Title/Abstract] AND VARS2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CD63(56121103)-VARS2(30893940), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CD63	GO:0034613	cellular protein localization	15647390
Hgene	CD63	GO:1901379	regulation of potassium ion transmembrane transport	15647390

Fusion gene breakpoints across CD63 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across VARS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BF857641	CD63	chr12	56121103	+	VARS2	chr6	30893940	+

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Fusion Gene ORF analysis for CD63-VARS2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000548898	ENST00000542001	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000548898	ENST00000416670	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000548898	ENST00000321897	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000548898	ENST00000541562	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3UTR	ENST00000548898	ENST00000476162	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548898	ENST00000547340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548898	ENST00000450090	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548898	ENST00000549458	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548898	ENST00000475174	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548898	ENST00000550773	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548898	ENST00000383540	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548898	ENST00000552560	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548898	ENST00000489340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548898	ENST00000551709	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548898	ENST00000415079	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548898	ENST00000546854	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548898	ENST00000462929	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000552067	ENST00000542001	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000552067	ENST00000416670	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000552067	ENST00000321897	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000552067	ENST00000541562	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3UTR	ENST00000552067	ENST00000476162	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552067	ENST00000547340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552067	ENST00000450090	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552067	ENST00000549458	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552067	ENST00000475174	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552067	ENST00000550773	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552067	ENST00000383540	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552067	ENST00000552560	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552067	ENST00000489340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552067	ENST00000551709	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552067	ENST00000415079	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552067	ENST00000546854	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552067	ENST00000462929	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000420846	ENST00000542001	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000420846	ENST00000416670	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000420846	ENST00000321897	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000420846	ENST00000541562	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3UTR	ENST00000420846	ENST00000476162	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000420846	ENST00000547340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000420846	ENST00000450090	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000420846	ENST00000549458	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000420846	ENST00000475174	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000420846	ENST00000550773	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000420846	ENST00000383540	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000420846	ENST00000552560	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000420846	ENST00000489340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000420846	ENST00000551709	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000420846	ENST00000415079	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000420846	ENST00000546854	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000420846	ENST00000462929	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000548160	ENST00000542001	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000548160	ENST00000416670	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000548160	ENST00000321897	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000548160	ENST00000541562	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3UTR	ENST00000548160	ENST00000476162	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548160	ENST00000547340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548160	ENST00000450090	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548160	ENST00000549458	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548160	ENST00000475174	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548160	ENST00000550773	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548160	ENST00000383540	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548160	ENST00000552560	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548160	ENST00000489340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548160	ENST00000551709	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548160	ENST00000415079	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548160	ENST00000546854	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000548160	ENST00000462929	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000546939	ENST00000542001	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000546939	ENST00000416670	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000546939	ENST00000321897	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000546939	ENST00000541562	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3UTR	ENST00000546939	ENST00000476162	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000546939	ENST00000547340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000546939	ENST00000450090	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000546939	ENST00000549458	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000546939	ENST00000475174	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000546939	ENST00000550773	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000546939	ENST00000383540	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000546939	ENST00000552560	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000546939	ENST00000489340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000546939	ENST00000551709	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000546939	ENST00000415079	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000546939	ENST00000546854	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000546939	ENST00000462929	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000552692	ENST00000542001	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000552692	ENST00000416670	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000552692	ENST00000321897	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000552692	ENST00000541562	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3UTR	ENST00000552692	ENST00000476162	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552692	ENST00000547340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552692	ENST00000450090	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552692	ENST00000549458	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552692	ENST00000475174	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552692	ENST00000550773	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552692	ENST00000383540	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552692	ENST00000552560	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552692	ENST00000489340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552692	ENST00000551709	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552692	ENST00000415079	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552692	ENST00000546854	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552692	ENST00000462929	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000549117	ENST00000542001	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000549117	ENST00000416670	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000549117	ENST00000321897	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000549117	ENST00000541562	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3UTR	ENST00000549117	ENST00000476162	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000549117	ENST00000547340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000549117	ENST00000450090	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000549117	ENST00000549458	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000549117	ENST00000475174	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000549117	ENST00000550773	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000549117	ENST00000383540	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000549117	ENST00000552560	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000549117	ENST00000489340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000549117	ENST00000551709	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000549117	ENST00000415079	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000549117	ENST00000546854	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000549117	ENST00000462929	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000257857	ENST00000542001	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000257857	ENST00000416670	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000257857	ENST00000321897	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000257857	ENST00000541562	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3UTR	ENST00000257857	ENST00000476162	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000257857	ENST00000547340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000257857	ENST00000450090	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000257857	ENST00000549458	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000257857	ENST00000475174	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000257857	ENST00000550773	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000257857	ENST00000383540	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000257857	ENST00000552560	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000257857	ENST00000489340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000257857	ENST00000551709	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000257857	ENST00000415079	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000257857	ENST00000546854	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000257857	ENST00000462929	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000552754	ENST00000542001	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000552754	ENST00000416670	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000552754	ENST00000321897	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000552754	ENST00000541562	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3UTR	ENST00000552754	ENST00000476162	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552754	ENST00000547340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552754	ENST00000450090	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552754	ENST00000549458	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552754	ENST00000475174	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552754	ENST00000550773	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552754	ENST00000383540	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552754	ENST00000552560	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552754	ENST00000489340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552754	ENST00000551709	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552754	ENST00000415079	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552754	ENST00000546854	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000552754	ENST00000462929	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000550776	ENST00000542001	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000550776	ENST00000416670	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000550776	ENST00000321897	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3CDS	ENST00000550776	ENST00000541562	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-3UTR	ENST00000550776	ENST00000476162	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000550776	ENST00000547340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000550776	ENST00000450090	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000550776	ENST00000549458	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000550776	ENST00000475174	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000550776	ENST00000550773	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000550776	ENST00000383540	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000550776	ENST00000552560	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000550776	ENST00000489340	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000550776	ENST00000551709	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000550776	ENST00000415079	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000550776	ENST00000546854	CD63	chr12	56121103	+	VARS2	chr6	30893940	+
intron-intron	ENST00000550776	ENST00000462929	CD63	chr12	56121103	+	VARS2	chr6	30893940	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CD63-VARS2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CD63-VARS2

Go to
FGviewer for the breakpoints of :-:
.
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CD63 P08962	.
FUNCTION: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269\|PubMed:16917503, ECO:0000269\|PubMed:21803846, ECO:0000269\|PubMed:21962903, ECO:0000269\|PubMed:23632027, ECO:0000269\|PubMed:24635319}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CD63-VARS2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CD63-VARS2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CD63-VARS2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CD63-VARS2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CD63	C0019207	Hepatoma, Morris	1	CTD_human
Hgene	CD63	C0019208	Hepatoma, Novikoff	1	CTD_human
Hgene	CD63	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	CD63	C0023904	Liver Neoplasms, Experimental	1	CTD_human
Hgene	CD63	C0086404	Experimental Hepatoma	1	CTD_human
Tgene	VARS2	C4014660	COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 20	2	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT